Hemocyanin middle domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All alpha proteins [ 46456] (284)
• Fold: Di-copper centre-containing domain [ 48055]
• Superfamily: Di-copper centre-containing domain [ 48056] (2)
• Family: Hemocyanin middle domain [ 48057] (2)

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Family statistics

	Genomes (44)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	283	2,013	6
Proteins	269	1,704	6

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	With another compound as one donor, and incorporat	0	2.264	--	DIRECT
Enzyme Commission (EC)	Oxidoreductases	0	0.3212	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on paired donors, with incorporation or red	0	1.173	Moderately Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	germ cell ionizing radiation response variant	0.00000008158	2.292	--	DIRECT
Worm Phenotype (WP)	organism ionizing radiation response variant	0.0000009212	2.07	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.7563	0.1444	--	INHERITED FROM: germ cell ionizing radiation response variant || cell stress response variant || organism ionizing radiation response variant || cell ionizing radiation response variant
Worm Phenotype (WP)	organism physiology variant	0.7688	0.1342	--	INHERITED FROM: germ cell ionizing radiation response variant || cell stress response variant || organism ionizing radiation response variant || cell ionizing radiation response variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || reproductive system physiology variant || organism ionizing radiation response variant || lethal || germ cell physiology variant || cell homeostasis metabolism variant || development variant || hermaphrodite sterile || hermaphrodite fertility reduced || germ cell ionizing radiation response variant || embryonic development variant || embryonic lethal || fertility variant || organ system physiology variant || maternal sterile || cell stress response variant || organism development variant || cell ionizing radiation response variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	organism environmental stimulus response variant	0.01285	0.6614	Least Informative	INHERITED FROM: cell stress response variant || germ cell ionizing radiation response variant || cell ionizing radiation response variant || organism ionizing radiation response variant
Worm Phenotype (WP)	cell physiology variant	0.01484	0.5955	Least Informative	INHERITED FROM: cell stress response variant || germ cell ionizing radiation response variant || cell homeostasis metabolism variant || germ cell physiology variant || cell ionizing radiation response variant
Worm Phenotype (WP)	cell homeostasis metabolism variant	0.0007595	1.036	Moderately Informative	DIRECT
Worm Phenotype (WP)	organism stress response variant	0.001837	0.9693	Moderately Informative	INHERITED FROM: cell ionizing radiation response variant || organism ionizing radiation response variant || cell stress response variant || germ cell ionizing radiation response variant
Worm Phenotype (WP)	cell stress response variant	0.000005367	1.538	Informative	DIRECT
Worm Phenotype (WP)	germ cell physiology variant	0.00008361	1.49	Informative	DIRECT
Worm Phenotype (WP)	cell ionizing radiation response variant	0.0000002962	2.07	Highly Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	With another compound as one donor, and incorporation of one atom of oxygen	0	2.628	--	DIRECT
Enzyme Commission (EC)	Tyrosinase	0	2.753	--	DIRECT
Enzyme Commission (EC)	Oxidoreductases	0	0.7328	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate	0	1.514	Informative	DIRECT

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