Worm Phenotype (WP): cell type morphology variant 

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children)	WP term [WP ID] <#Children>	#Domains (Superfamily|Family)	#Supra-domain (Single|Duplex|Triple)
+ + + 3:	Variant [WBPhenotype:0000886] <2>
+ + 2:	morphology variant [WBPhenotype:0000520] <5>	(443|528)	(444|229|63)
+ 1:	cell morphology variant [WBPhenotype:0000533] <10>	(104|103)	(106|55|17)
0:	cell type morphology variant [WBPhenotype:0002108] <12>	(77|76)	(79|45|15)
- 1:	epithelial cell morphology variant [WBPhenotype:0000899] <5>	(6|3)	(6|1|1)
- 1:	neuron morphology variant [WBPhenotype:0000905] <5>	(13|8)	(14|5|2)
- 1:	germ cell morphology variant [WBPhenotype:0000900] <4>	(44|41)	(45|23|8)
- 1:	muscle cell morphology variant [WBPhenotype:0000904] <4>	(23|27)	(23|16|6)
- 1:	embryonic cell morphology variant [WBPhenotype:0000770] <2>	(3|4)	(3|2|0)
- 1:	germline precursor cell morphology variant [WBPhenotype:0002485] <1>	(0|0)	(0|0|0)
- 1:	gland cell morphology variant [WBPhenotype:0000901] <1>	(0|0)	(0|0|0)
- 1:	intestinal cell morphology variant [WBPhenotype:0000902] <1>	(0|0)	(0|0|0)
- 1:	blast cell morphology variant [WBPhenotype:0000898]	(0|0)	(0|0|0)
- 1:	distal tip cell morphology variant [WBPhenotype:0000196]	(0|0)	(0|0|0)
- 1:	linker cell morphology variant [WBPhenotype:0002139]	(0|0)	(0|0|0)
- 1:	uterine vulval cell morphology variant [WBPhenotype:0000906]	(0|0)	(0|0|0)

Superfamily

Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Helical domain of Sec23/24	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Integrin alpha N-terminal domain	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Integrin domains	0	DIRECT
Sm-like ribonucleoproteins	0.00000001453	DIRECT
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0.00003787	DIRECT
Spectrin repeat	0.00007699	DIRECT
Cysteine-rich domain	0.00007764	DIRECT
P-loop containing nucleoside triphosphate hydrolases	0.0001739	DIRECT
Translation proteins SH3-like domain	0.0001942	DIRECT
Ribosomal proteins S24e, L23 and L15e	0.0002137	DIRECT
Calpain large subunit, middle domain (domain III)	0.0006393	DIRECT
Class II aaRS ABD-related	0.0006393	DIRECT
Metal cation-transporting ATPase, ATP-binding domain N	0.00101	INHERITED FROM: epithelial cell morphology variant || seam cell morphology variant
Annexin	0.001326	INHERITED FROM: germ cell morphology variant
ADC-like	0.001326	INHERITED FROM: germ cell morphology variant || cytoplasmic processing body variant || germ cell cytoplasmic morphology variant
Cdc48 domain 2-like	0.001326	INHERITED FROM: germ cell morphology variant || cytoplasmic processing body variant || germ cell cytoplasmic morphology variant
beta-sandwich domain of Sec23/24	0.001326	INHERITED FROM: germ cell morphology variant || germ cell compartment size variant || oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment expansion variant
Calcium ATPase, transmembrane domain M	0.001567	INHERITED FROM: epithelial cell morphology variant || seam cell morphology variant
CCCH zinc finger	0.002507	INHERITED FROM: P granule abnormal || germ cell cytoplasmic morphology variant
Zn-binding ribosomal proteins	0.003001	INHERITED FROM: germ cell morphology variant || cytoplasmic processing body variant
PLC-like phosphodiesterases	0.003034	INHERITED FROM: germ cell morphology variant || oocyte morphology variant || endomitotic oocytes
Calcium ATPase, transduction domain A	0.003107	INHERITED FROM: epithelial cell morphology variant || seam cell morphology variant
C2 domain (Calcium/lipid-binding domain, CaLB)	0.004894	INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant || endomitotic oocytes
Nucleic acid-binding proteins	0.004894	INHERITED FROM: cytoplasmic processing body variant || germ cell compartment expansion variant || embryonic cell morphology variant || nuclear appearance number defective early emb || oocyte number decreased
F1F0 ATP synthase subunit C	0.005316	INHERITED FROM: germ cell morphology variant || oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment expansion variant || oocytes lack nucleus || germ cell compartment anucleate || germ cell compartment nuclei number variant
S15/NS1 RNA-binding domain	0.005316	INHERITED FROM: germ cell morphology variant || oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment expansion variant
PYP-like sensor domain (PAS domain)	0.00661	INHERITED FROM: neurite morphology variant
Myosin rod fragments	0.01238	INHERITED FROM: striated muscle morphology variant || body wall muscle thick filament variant || body wall muscle sarcomere morphology variant || muscle cell morphology variant
L30e-like	0.01238	INHERITED FROM: oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment expansion variant || oocyte number decreased
Translational machinery components	0.01305	INHERITED FROM: oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment expansion variant || oocyte number decreased
Calponin-homology domain, CH-domain	0.01336	INHERITED FROM: striated muscle morphology variant || body wall muscle myosin organization defective
SH2 domain	0.01336	INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant || muscle cell morphology variant
Second domain of FERM	0.01726	INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant
ACP-like	0.02525	INHERITED FROM: oocyte morphology variant || oocyte number decreased
Fibronectin type III	0.04169	INHERITED FROM: commissure absent || neuron morphology variant || axon morphology variant || body wall muscle sarcomere morphology variant || neurite morphology variant
SH3-domain	0.04749	INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant || endomitotic oocytes || muscle cell morphology variant
RNA-binding domain, RBD	0.05736	INHERITED FROM: P granule localization defective || oocytes disorganized
SMAD/FHA domain	0.08285	INHERITED FROM: axon branching variant
PH domain-like	0.09421	INHERITED FROM: axon morphology variant || endomitotic oocytes || muscle cell morphology variant
Ribosomal protein S5 domain 2-like	0.09541	INHERITED FROM: germ cell compartment expansion variant
Class II aaRS and biotin synthetases	0.09541	INHERITED FROM: germ cell morphology variant || cytoplasmic processing body variant || germ cell compartment expansion variant || germ cell compartment anucleate
Protein kinase-like (PK-like)	0.114	INHERITED FROM: myopodia present || muscle cell morphology variant
Concanavalin A-like lectins/glucanases	0.1147	INHERITED FROM: commissure handedness defective || axon morphology variant || neurite morphology variant
Actin-like ATPase domain	0.1147	INHERITED FROM: germ cell morphology variant || body wall muscle myosin organization defective
Immunoglobulin	0.1313	INHERITED FROM: sperm pseudopod variant || neuron morphology variant || sperm morphology variant || body wall muscle sarcomere morphology variant || neurite morphology variant || muscle cell morphology variant
GTPase activation domain, GAP	0.1919	INHERITED FROM: neuron morphology variant || axon morphology variant || neurite morphology variant || axon branching variant
DBL homology domain (DH-domain)	0.1945	INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant
dsRNA-binding domain-like	0.2446	INHERITED FROM: germ cell morphology variant || cytoplasmic processing body variant
HAD-like	0.261	INHERITED FROM: epithelial cell morphology variant || seam cell morphology variant
ARM repeat	0.2964	INHERITED FROM: P granule localization defective || seam cell morphology variant
EF-hand	0.3053	INHERITED FROM: endomitotic oocytes
EGF/Laminin	0.3065	INHERITED FROM: body wall muscle sarcomere morphology variant || axon trajectory variant || muscle cell morphology variant
Sec1/munc18-like (SM) proteins	0.3076	INHERITED FROM: epithelial cell morphology variant || seam cell morphology variant
Troponin coil-coiled subunits	0.3076	INHERITED FROM: body wall muscle sarcomere morphology variant || muscle cell morphology variant
Activating enzymes of the ubiquitin-like proteins	0.3849	INHERITED FROM: germ cell morphology variant || germ cell compartment nuclei number variant
Translation proteins	0.403	INHERITED FROM: germ cell morphology variant || germ cell compartment expansion variant
GroEL apical domain-like	0.403	INHERITED FROM: oocytes small || oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment expansion variant || germ cell compartment anucleate
GroEL-intermediate domain like	0.47	INHERITED FROM: germ cell morphology variant || oocytes small || oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment expansion variant || germ cell compartment anucleate
GroEL equatorial domain-like	0.47	INHERITED FROM: germ cell morphology variant || oocytes small || oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment expansion variant || germ cell compartment anucleate
Cyclin-like	0.47	INHERITED FROM: multiple nuclei early emb || pronuclear size defective early emb || excess maternal pronucleus early emb || nuclear morphology variation early emb || excess pronucleus early emb || embryonic cell morphology variant || nuclear appearance number defective early emb
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0.4784	INHERITED FROM: germ cell compartment morphology variant || germ cell compartment expansion variant || oocyte number decreased
RBP11-like subunits of RNA polymerase	0.4784	INHERITED FROM: germ cell morphology variant
TPR-like	0.4893	INHERITED FROM: cilia morphology variant || ciliated neuron morphology variant
Glutathione synthetase ATP-binding domain-like	0.6246	INHERITED FROM: body wall muscle myosin organization defective || body wall muscle thick filament variant
Growth factor receptor domain	0.6426	INHERITED FROM: body wall muscle sarcomere morphology variant || muscle cell morphology variant
Voltage-gated potassium channels	0.711	INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant || muscle cell morphology variant
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0.7136	INHERITED FROM: oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment expansion variant || oocyte number decreased
Tubulin C-terminal domain-like	0.7717	INHERITED FROM: axon morphology variant
Tubulin nucleotide-binding domain-like	0.8286	INHERITED FROM: axon morphology variant
Tropomyosin	0.8491	INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant
PDZ domain-like	0.9162	INHERITED FROM: endomitotic oocytes
L domain-like	1	INHERITED FROM: myopodia present

Family

Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
POU-specific domain	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
beta-sandwich domain of Sec23/24	0	DIRECT
Inositol polyphosphate 5-phosphatase (IPP5)	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
Group II chaperonin (CCT, TRIC), intermediate domain	0	DIRECT
Mammalian PLC	0	DIRECT
Trunk domain of Sec23/24	0	DIRECT
Integrin domains	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Anticodon-binding domain of Class II aaRS	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
Proteasome subunits	0.000000152	DIRECT
Sm motif of small nuclear ribonucleoproteins, SNRNP	0.0000007276	DIRECT
Clathrin coat assembly domain	0.00001302	DIRECT
Spectrin repeat	0.00007068	DIRECT
DNA replication initiator (cdc21/cdc54) N-terminal domain	0.00007101	DIRECT
Laminin-type module	0.00007101	DIRECT
PLC-like (P variant)	0.0002116	DIRECT
EF-hand modules in multidomain proteins	0.0003817	DIRECT
Calpain large subunit, middle domain (domain III)	0.001294	INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant || muscle cell morphology variant
First domain of FERM	0.001833	INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant
Cdc48 domain 2-like	0.002022	INHERITED FROM: germ cell morphology variant || cytoplasmic processing body variant || germ cell cytoplasmic morphology variant
Annexin	0.002022	INHERITED FROM: germ cell morphology variant
Anticodon-binding domain	0.002022	INHERITED FROM: germ cell morphology variant || oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment expansion variant || oocyte number decreased
Troponin I	0.002022	INHERITED FROM: muscle cell morphology variant
Cdc48 N-terminal domain-like	0.002022	INHERITED FROM: germ cell morphology variant || cytoplasmic processing body variant || germ cell cytoplasmic morphology variant
Lamin A/C globular tail domain	0.003167	INHERITED FROM: body wall muscle sarcomere morphology variant
Third domain of FERM	0.006475	INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant
CCCH zinc finger	0.008016	INHERITED FROM: P granule abnormal || germ cell cytoplasmic morphology variant
L30e/L7ae ribosomal proteins	0.008074	INHERITED FROM: oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment expansion variant || oocyte number decreased
F1F0 ATP synthase subunit C	0.008074	INHERITED FROM: oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment expansion variant || oocytes lack nucleus || germ cell compartment anucleate || germ cell compartment nuclei number variant
Calcium ATPase, transduction domain A	0.008208	INHERITED FROM: epithelial cell morphology variant || seam cell morphology variant
Translational machinery components	0.01133	INHERITED FROM: germ cell morphology variant || oocytes small || oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment expansion variant
Heat shock protein 70kD (HSP70), peptide-binding domain	0.01133	INHERITED FROM: germ cell morphology variant
Nitrogenase iron protein-like	0.01173	INHERITED FROM: oocyte number decreased
Laminin G-like module	0.01173	INHERITED FROM: commissure handedness defective || neuron morphology variant || axon morphology variant || myopodia present || neurite morphology variant
Calponin-homology domain, CH-domain	0.01246	INHERITED FROM: striated muscle morphology variant || body wall muscle myosin organization defective
Canonical RBD	0.01465	INHERITED FROM: P granule localization defective || oocytes disorganized
Motor proteins	0.01703	INHERITED FROM: axon morphology variant || cord commissures variant || neurite morphology variant || axon branching variant || cord commissures fail to reach target
Myosin rod fragments	0.02097	INHERITED FROM: striated muscle morphology variant || body wall muscle thick filament variant || body wall muscle sarcomere morphology variant || muscle cell morphology variant
Cold shock DNA-binding domain-like	0.02268	INHERITED FROM: germ cell morphology variant || cytoplasmic processing body variant || germ cell compartment expansion variant || germ cell cytoplasmic morphology variant || oocyte number decreased
SH2 domain	0.0227	INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant || muscle cell morphology variant
Second domain of FERM	0.02488	INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant
Actin/HSP70	0.03364	INHERITED FROM: germ cell morphology variant || cytoplasmic processing body variant || body wall muscle myosin organization defective || body wall muscle sarcomere morphology variant || germ cell compartment nuclei number variant
BCR-homology GTPase activation domain (BH-domain)	0.03364	INHERITED FROM: neuron morphology variant || axon morphology variant || neurite morphology variant || axon branching variant
Fibronectin type III	0.03995	INHERITED FROM: commissure absent || neuron morphology variant || axon morphology variant || body wall muscle sarcomere morphology variant || neurite morphology variant
G proteins	0.04044	INHERITED FROM: epithelial cell morphology variant || seam cell morphology variant || multiple nuclei oocyte
Calpain large subunit, catalytic domain (domain II)	0.0433	INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant || muscle cell morphology variant
SH3-domain	0.04655	INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant || muscle cell morphology variant
Pleckstrin-homology domain (PH domain)	0.0492	INHERITED FROM: striated muscle morphology variant || axon morphology variant || body wall muscle sarcomere morphology variant || endomitotic oocytes || muscle cell morphology variant
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain	0.08914	INHERITED FROM: germ cell morphology variant || cytoplasmic processing body variant || germ cell compartment expansion variant || germ cell compartment anucleate
FHA domain	0.1018	INHERITED FROM: axon morphology variant || neurite morphology variant || axon branching variant
Protein kinases, catalytic subunit	0.1404	INHERITED FROM: myopodia present || muscle cell morphology variant
Group II chaperonin (CCT, TRIC), apical domain	0.144	INHERITED FROM: oocytes small || oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment expansion variant || germ cell compartment anucleate
DBL homology domain (DH-domain)	0.1832	INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant
Group II chaperonin (CCT, TRIC), ATPase domain	0.1832	INHERITED FROM: germ cell morphology variant || oocytes small || oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment expansion variant || germ cell compartment anucleate
LIM domain	0.1832	INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant || muscle cell morphology variant
I set domains	0.1949	INHERITED FROM: body wall muscle sarcomere morphology variant || neurite morphology variant || muscle cell morphology variant
Cyclin	0.232	INHERITED FROM: multiple nuclei early emb || pronuclear size defective early emb || excess maternal pronucleus early emb || nuclear morphology variation early emb || excess pronucleus early emb || embryonic cell morphology variant || nuclear appearance number defective early emb
Synaptotagmin-like (S variant)	0.232	INHERITED FROM: body wall muscle sarcomere morphology variant
Sec1/munc18-like (SM) proteins	0.2926	INHERITED FROM: epithelial cell morphology variant || seam cell morphology variant
Elongation factors	0.2926	INHERITED FROM: oocytes small || oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment expansion variant
Extended AAA-ATPase domain	0.2964	INHERITED FROM: germ cell compartment small || embryonic cell morphology variant || germ cell compartment anucleate
RecA protein-like (ATPase-domain)	0.3699	INHERITED FROM: germ cell morphology variant || oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment anucleate
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0.4606	INHERITED FROM: germ cell compartment expansion variant || oocyte number decreased
Pumilio repeat	0.5338	INHERITED FROM: germ cell morphology variant || multiple nuclei early emb || oocytes stacked || nuclear number defective early emb || oocyte morphology variant || embryonic cell morphology variant || nuclear appearance number defective early emb
Clathrin adaptor core protein	0.7008	INHERITED FROM: oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment expansion variant || germ cell compartment nuclei number variant
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0.7911	INHERITED FROM: germ cell compartment expansion variant || oocyte number decreased
Tubulin, GTPase domain	0.8215	INHERITED FROM: axon morphology variant
Tropomyosin	0.8399	INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant
Growth factor receptor domain	0.9024	INHERITED FROM: myopodia present
Class I aminoacyl-tRNA synthetases (RS), catalytic domain	0.9024	INHERITED FROM: oocyte number decreased
PDZ domain	0.9241	INHERITED FROM: endomitotic oocytes

Supra-domain (Single|Duplex|Triple)

Supra-domain (Single)

Highlighted in gray are those with FDR>0.001

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
Integrin domains	0	DIRECT
Integrin alpha N-terminal domain	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
Sm-like ribonucleoproteins	0.00000001159	DIRECT
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0.00003094	DIRECT
Spectrin repeat	0.000063	DIRECT
Cysteine-rich domain	0.00006354	DIRECT
P-loop containing nucleoside triphosphate hydrolases	0.0001427	DIRECT
Translation proteins SH3-like domain	0.0001595	DIRECT
Ribosomal proteins S24e, L23 and L15e	0.0001757	DIRECT
Calpain large subunit, middle domain (domain III)	0.0005298	DIRECT
Class II aaRS ABD-related	0.0005298	DIRECT
Metal cation-transporting ATPase, ATP-binding domain N	0.0008407	DIRECT
Actin depolymerizing proteins	0.0008682	DIRECT
Cdc48 domain 2-like	0.001106	INHERITED FROM: cytoplasmic processing body variant || germ cell morphology variant || germ cell cytoplasmic morphology variant
beta-sandwich domain of Sec23/24	0.001106	INHERITED FROM: germ cell compartment morphology variant || germ cell compartment expansion variant || germ cell morphology variant || oocyte morphology variant || germ cell compartment size variant
ADC-like	0.001106	INHERITED FROM: cytoplasmic processing body variant || germ cell morphology variant || germ cell cytoplasmic morphology variant
Annexin	0.001106	INHERITED FROM: germ cell morphology variant
Calcium ATPase, transmembrane domain M	0.00131	INHERITED FROM: seam cell morphology variant || epithelial cell morphology variant
CCCH zinc finger	0.00211	INHERITED FROM: P granule abnormal || germ cell cytoplasmic morphology variant
Zn-binding ribosomal proteins	0.002533	INHERITED FROM: cytoplasmic processing body variant || germ cell morphology variant
PLC-like phosphodiesterases	0.002561	INHERITED FROM: germ cell morphology variant || oocyte morphology variant || endomitotic oocytes
Calcium ATPase, transduction domain A	0.002623	INHERITED FROM: seam cell morphology variant || epithelial cell morphology variant
C2 domain (Calcium/lipid-binding domain, CaLB)	0.004157	INHERITED FROM: body wall muscle sarcomere morphology variant || striated muscle morphology variant || axon morphology variant || endomitotic oocytes
Nucleic acid-binding proteins	0.004157	INHERITED FROM: cytoplasmic processing body variant || oocyte number decreased || germ cell compartment expansion variant || nuclear appearance number defective early emb || embryonic cell morphology variant
F1F0 ATP synthase subunit C	0.00452	INHERITED FROM: germ cell compartment anucleate || oocytes lack nucleus || germ cell compartment morphology variant || germ cell compartment expansion variant || germ cell morphology variant || oocyte morphology variant || germ cell compartment nuclei number variant
S15/NS1 RNA-binding domain	0.00452	INHERITED FROM: germ cell compartment morphology variant || germ cell compartment expansion variant || germ cell morphology variant || oocyte morphology variant
PYP-like sensor domain (PAS domain)	0.005637	INHERITED FROM: neurite morphology variant
Myosin rod fragments	0.01069	INHERITED FROM: body wall muscle sarcomere morphology variant || muscle cell morphology variant || striated muscle morphology variant || body wall muscle thick filament variant
Heat shock protein 70kD (HSP70), peptide-binding domain	0.01069	INHERITED FROM: germ cell morphology variant
L30e-like	0.01069	INHERITED FROM: germ cell compartment morphology variant || oocyte number decreased || germ cell compartment expansion variant || germ cell morphology variant || oocyte morphology variant
Translational machinery components	0.01127	INHERITED FROM: germ cell compartment morphology variant || oocyte number decreased || germ cell compartment expansion variant || oocyte morphology variant
SH2 domain	0.01155	INHERITED FROM: body wall muscle sarcomere morphology variant || muscle cell morphology variant || striated muscle morphology variant
Calponin-homology domain, CH-domain	0.01155	INHERITED FROM: striated muscle morphology variant || body wall muscle myosin organization defective
Second domain of FERM	0.01498	INHERITED FROM: body wall muscle sarcomere morphology variant || striated muscle morphology variant
ACP-like	0.02209	INHERITED FROM: oocyte number decreased || oocyte morphology variant
Fibronectin type III	0.03678	INHERITED FROM: body wall muscle sarcomere morphology variant || neuron morphology variant || neurite morphology variant || commissure absent || axon morphology variant
SH3-domain	0.04203	INHERITED FROM: body wall muscle sarcomere morphology variant || muscle cell morphology variant || striated muscle morphology variant || endomitotic oocytes
RNA-binding domain, RBD	0.05101	INHERITED FROM: P granule localization defective || oocytes disorganized
SMAD/FHA domain	0.07441	INHERITED FROM: axon branching variant
PH domain-like	0.08492	INHERITED FROM: muscle cell morphology variant || axon morphology variant || endomitotic oocytes
Ribosomal protein S5 domain 2-like	0.08604	INHERITED FROM: germ cell compartment expansion variant
Class II aaRS and biotin synthetases	0.08604	INHERITED FROM: germ cell compartment anucleate || cytoplasmic processing body variant || germ cell compartment expansion variant || germ cell morphology variant
Protein kinase-like (PK-like)	0.1033	INHERITED FROM: muscle cell morphology variant || myopodia present
Concanavalin A-like lectins/glucanases	0.1039	INHERITED FROM: commissure handedness defective || neurite morphology variant || axon morphology variant
Actin-like ATPase domain	0.1039	INHERITED FROM: germ cell morphology variant || body wall muscle myosin organization defective
Immunoglobulin	0.1194	INHERITED FROM: body wall muscle sarcomere morphology variant || muscle cell morphology variant || myopodia present || sperm morphology variant || sperm pseudopod variant || neuron morphology variant || neurite morphology variant
GTPase activation domain, GAP	0.1765	INHERITED FROM: neuron morphology variant || neurite morphology variant || axon branching variant || axon morphology variant
DBL homology domain (DH-domain)	0.1789	INHERITED FROM: body wall muscle sarcomere morphology variant || striated muscle morphology variant
dsRNA-binding domain-like	0.227	INHERITED FROM: cytoplasmic processing body variant || germ cell morphology variant
HAD-like	0.243	INHERITED FROM: seam cell morphology variant || epithelial cell morphology variant
ARM repeat	0.2774	INHERITED FROM: seam cell morphology variant || P granule localization defective
EF-hand	0.2861	INHERITED FROM: endomitotic oocytes
EGF/Laminin	0.2873	INHERITED FROM: body wall muscle sarcomere morphology variant || muscle cell morphology variant || axon trajectory variant
Sec1/munc18-like (SM) proteins	0.2883	INHERITED FROM: seam cell morphology variant || epithelial cell morphology variant
Troponin coil-coiled subunits	0.2883	INHERITED FROM: body wall muscle sarcomere morphology variant || muscle cell morphology variant
Activating enzymes of the ubiquitin-like proteins	0.3644	INHERITED FROM: germ cell morphology variant || germ cell compartment nuclei number variant
GroEL apical domain-like	0.3824	INHERITED FROM: germ cell compartment anucleate || germ cell compartment morphology variant || germ cell compartment expansion variant || oocyte morphology variant || oocytes small
Translation proteins	0.3824	INHERITED FROM: germ cell compartment expansion variant || germ cell morphology variant
GroEL equatorial domain-like	0.4489	INHERITED FROM: germ cell compartment anucleate || germ cell compartment morphology variant || germ cell compartment expansion variant || germ cell morphology variant || oocyte morphology variant || oocytes small
Cyclin-like	0.4489	INHERITED FROM: pronuclear size defective early emb || excess maternal pronucleus early emb || excess pronucleus early emb || nuclear appearance number defective early emb || multiple nuclei early emb || embryonic cell morphology variant || nuclear morphology variation early emb
GroEL-intermediate domain like	0.4489	INHERITED FROM: germ cell compartment anucleate || germ cell compartment morphology variant || germ cell compartment expansion variant || germ cell morphology variant || oocyte morphology variant || oocytes small
RBP11-like subunits of RNA polymerase	0.457	INHERITED FROM: germ cell morphology variant
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0.457	INHERITED FROM: germ cell compartment morphology variant || oocyte number decreased || germ cell compartment expansion variant
TPR-like	0.4677	INHERITED FROM: cilia morphology variant || ciliated neuron morphology variant
Glutathione synthetase ATP-binding domain-like	0.6026	INHERITED FROM: body wall muscle thick filament variant || body wall muscle myosin organization defective
Growth factor receptor domain	0.6208	INHERITED FROM: body wall muscle sarcomere morphology variant || muscle cell morphology variant
Voltage-gated potassium channels	0.6903	INHERITED FROM: body wall muscle sarcomere morphology variant || muscle cell morphology variant || striated muscle morphology variant
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0.693	INHERITED FROM: germ cell compartment morphology variant || oocyte number decreased || germ cell compartment expansion variant || oocyte morphology variant
Tubulin C-terminal domain-like	0.7527	INHERITED FROM: axon morphology variant
Tubulin nucleotide-binding domain-like	0.8108	INHERITED FROM: axon morphology variant
Tropomyosin	0.8321	INHERITED FROM: body wall muscle sarcomere morphology variant || striated muscle morphology variant
PDZ domain-like	0.9013	INHERITED FROM: endomitotic oocytes
L domain-like	1	INHERITED FROM: myopodia present

Supra-domain (Duplex) in N- to C-terminal order

Highlighted in gray are those with FDR>0.001

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
64356,49447 64356 - SNARE-like 49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	0	DIRECT
81811,82754 81811 - Helical domain of Sec23/24 82754 - C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
50729,47473 50729 - PH domain-like 47473 - EF-hand	0	DIRECT
49265,48726 49265 - Fibronectin type III 48726 - Immunoglobulin	0	DIRECT
56112,48371 56112 - Protein kinase-like (PK-like) 48371 - ARM repeat	0	DIRECT
47473,51695 47473 - EF-hand 51695 - PLC-like phosphodiesterases	0	DIRECT
51695,49562 51695 - PLC-like phosphodiesterases 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)	0	DIRECT
54585,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
52540,47917 52540 - P-loop containing nucleoside triphosphate hydrolases 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
82919,53300 82919 - Zn-finger domain of Sec23/24 53300 - vWA-like	0	DIRECT
50692,54585 50692 - ADC-like 54585 - Cdc48 domain 2-like	0	DIRECT
46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat	0.000004215	DIRECT
54001,49758 54001 - Cysteine proteinases 49758 - Calpain large subunit, middle domain (domain III)	0.0001589	DIRECT
50044,55550 50044 - SH3-domain 55550 - SH2 domain	0.0001589	DIRECT
64593,74853 64593 - Intermediate filament protein, coiled coil region 74853 - Lamin A/C globular tail domain	0.0001589	DIRECT
81660,56784 81660 - Metal cation-transporting ATPase, ATP-binding domain N 56784 - HAD-like	0.0008407	DIRECT
55681,52954 55681 - Class II aaRS and biotin synthetases 52954 - Class II aaRS ABD-related	0.001106	INHERITED FROM: germ cell morphology variant
55550,50044 55550 - SH2 domain 50044 - SH3-domain	0.001106	INHERITED FROM: body wall muscle sarcomere morphology variant || muscle cell morphology variant || striated muscle morphology variant
81333,81333 81333 - F1F0 ATP synthase subunit C 81333 - F1F0 ATP synthase subunit C	0.001106	INHERITED FROM: germ cell compartment anucleate || oocytes lack nucleus || germ cell compartment morphology variant || germ cell compartment expansion variant || germ cell morphology variant || oocyte morphology variant || germ cell compartment nuclei number variant
50044,50044 50044 - SH3-domain 50044 - SH3-domain	0.002533	INHERITED FROM: body wall muscle sarcomere morphology variant || striated muscle morphology variant
47031,50729 47031 - Second domain of FERM 50729 - PH domain-like	0.002561	INHERITED FROM: body wall muscle sarcomere morphology variant || striated muscle morphology variant
50249,55681 50249 - Nucleic acid-binding proteins 55681 - Class II aaRS and biotin synthetases	0.00452	INHERITED FROM: germ cell compartment morphology variant || oocyte number decreased || germ cell compartment expansion variant || germ cell morphology variant || oocyte morphology variant
100920,100934 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain	0.005637	INHERITED FROM: germ cell morphology variant
53067,100920 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain	0.01069	INHERITED FROM: germ cell morphology variant
54236,47031 54236 - Ubiquitin-like 47031 - Second domain of FERM	0.01386	INHERITED FROM: body wall muscle sarcomere morphology variant || striated muscle morphology variant
52374,47323 52374 - Nucleotidylyl transferase 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0.02209	INHERITED FROM: germ cell compartment morphology variant || oocyte number decreased || germ cell compartment expansion variant || oocyte morphology variant
90257,90257 90257 - Myosin rod fragments 90257 - Myosin rod fragments	0.02209	INHERITED FROM: body wall muscle sarcomere morphology variant || muscle cell morphology variant || striated muscle morphology variant || body wall muscle thick filament variant
54928,54928 54928 - RNA-binding domain, RBD 54928 - RNA-binding domain, RBD	0.04788	INHERITED FROM: oocytes disorganized
90229,90229 90229 - CCCH zinc finger 90229 - CCCH zinc finger	0.05311	INHERITED FROM: P granule abnormal || germ cell cytoplasmic morphology variant
48452,48452 48452 - TPR-like 48452 - TPR-like	0.06728	INHERITED FROM: nuclear appearance number defective early emb || nuclear number defective early emb
53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain	0.1039	INHERITED FROM: cytoplasmic processing body variant || germ cell morphology variant || body wall muscle myosin organization defective
48726,49265 48726 - Immunoglobulin 49265 - Fibronectin type III	0.1101	INHERITED FROM: body wall muscle sarcomere morphology variant || neuron morphology variant || neurite morphology variant || axon morphology variant
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin	0.1765	INHERITED FROM: body wall muscle sarcomere morphology variant || muscle cell morphology variant || sperm morphology variant || sperm pseudopod variant || muscle birefringence variant || neurite morphology variant || axon morphology variant
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin	0.1868	INHERITED FROM: body wall muscle sarcomere morphology variant || muscle cell morphology variant || myopodia present
57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain)	0.1868	INHERITED FROM: body wall muscle sarcomere morphology variant || muscle cell morphology variant || striated muscle morphology variant
47954,47954 47954 - Cyclin-like 47954 - Cyclin-like	0.227	INHERITED FROM: pronuclear size defective early emb || excess maternal pronucleus early emb || excess pronucleus early emb || nuclear appearance number defective early emb || nuclear number defective early emb || multiple nuclei early emb || embryonic cell morphology variant || nuclear morphology variation early emb
50978,50978 50978 - WD40 repeat-like 50978 - WD40 repeat-like	0.227	INHERITED FROM: cilia morphology variant || ciliated neuron morphology variant
48065,50729 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like	0.2883	INHERITED FROM: body wall muscle sarcomere morphology variant || striated muscle morphology variant
52540,50447 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins	0.2883	INHERITED FROM: germ cell compartment morphology variant || germ cell compartment expansion variant || oocyte morphology variant || oocytes small
48371,48371 48371 - ARM repeat 48371 - ARM repeat	0.3222	INHERITED FROM: cytoplasmic processing body variant
49265,49265 49265 - Fibronectin type III 49265 - Fibronectin type III	0.3644	INHERITED FROM: body wall muscle sarcomere morphology variant || striated muscle morphology variant || axon morphology variant
54849,52029 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like	0.4489	INHERITED FROM: germ cell compartment anucleate || germ cell compartment morphology variant || germ cell compartment expansion variant || germ cell morphology variant || oocyte morphology variant || oocytes small
48592,54849 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like	0.4489	INHERITED FROM: germ cell compartment anucleate || germ cell compartment morphology variant || germ cell compartment expansion variant || germ cell morphology variant || oocyte morphology variant || oocytes small
50447,50465 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0.457	INHERITED FROM: germ cell compartment morphology variant || oocyte number decreased || germ cell compartment expansion variant
52490,55307 52490 - Tubulin nucleotide-binding domain-like 55307 - Tubulin C-terminal domain-like	0.8108	INHERITED FROM: axon morphology variant

Supra-domain (Triple) in N- to C-terminal order

Highlighted in gray are those with FDR>0.001

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
48726,49265,48726 48726 - Immunoglobulin 49265 - Fibronectin type III 48726 - Immunoglobulin	0	DIRECT
50729,47473,51695 50729 - PH domain-like 47473 - EF-hand 51695 - PLC-like phosphodiesterases	0	DIRECT
50692,54585,52540 50692 - ADC-like 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
54585,52540,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
46966,46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat 46966 - Spectrin repeat	0	DIRECT
57716,57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain)	0.00000009691	DIRECT
48726,48726,49265 48726 - Immunoglobulin 48726 - Immunoglobulin 49265 - Fibronectin type III	0.00002036	DIRECT
81660,56784,81665 81660 - Metal cation-transporting ATPase, ATP-binding domain N 56784 - HAD-like 81665 - Calcium ATPase, transmembrane domain M	0.002623	INHERITED FROM: seam cell morphology variant || epithelial cell morphology variant
53067,100920,100934 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain	0.005637	INHERITED FROM: germ cell morphology variant
54236,47031,50729 54236 - Ubiquitin-like 47031 - Second domain of FERM 50729 - PH domain-like	0.008825	INHERITED FROM: body wall muscle sarcomere morphology variant || striated muscle morphology variant
53067,53067,100920 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain	0.01069	INHERITED FROM: germ cell morphology variant
57196,57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin 57196 - EGF/Laminin	0.227	INHERITED FROM: myopodia present
48726,48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin 48726 - Immunoglobulin	0.329	INHERITED FROM: body wall muscle sarcomere morphology variant || sperm morphology variant || sperm pseudopod variant || muscle birefringence variant || axon morphology variant || body wall muscle myosin organization defective
48592,54849,52029 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like	0.4489	INHERITED FROM: germ cell compartment anucleate || germ cell compartment morphology variant || germ cell compartment expansion variant || germ cell morphology variant || oocyte morphology variant || oocytes small
52540,50447,50465 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0.457	INHERITED FROM: germ cell compartment morphology variant || oocyte number decreased || germ cell compartment expansion variant