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CTD Diseases (CD): Nervous System Diseases 
(show info)
Biomedical Ontology
Like Gene Ontology (GO), biomedical ontology such as phenotype ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Biomedical ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI’s thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology Based on YP which is the major contributor to the ‘Ascomycete phenotype ontology’, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- UniProtKB KeyWords (KW) Ontology Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- CTD Diseases (CD) Ontology CD is MEDIC disease vocabulary that is modified by CTD from the "Diseases" [C] branch of Medical Subject Headings (MeSH), combined with genetic disorders from the Online Mendelian Inheritance in OMIM database.
- CTD Chemicals (CC) Ontology CC is chemical vocabulary that is adapted by CTD from the "Chemicals and Drugs" category and Supplementary Concept Records of Medical Subject Headings (MeSH, a hierarchical vocabulary used to index articles for MEDLINE/PubMed).
Jump to [ Top · Hierarchy · Annotations ]
Root: CD Hierarchy (CTD diseases from Comparative Toxicogenomics Database)
| Shortest distance to current term (+ for parents, - for children) |
CD term [CD ID] <#Children> |
#Domains (Superfamily|Family) |
#Supra-domain (Single|Duplex|Triple) |
| + 1: | Diseases [MESH:C] <25> |
| 0: | Nervous System Diseases [MESH:D009422] <27> | (86|87) |
(91|33|8) |
| - 1: | Nervous System Malformations [MESH:D009421] <27> | (7|9) |
(7|2|0) |
| - 1: | Neurologic Manifestations [MESH:D009461] <26> | (22|24) |
(25|9|1) |
| - 1: | Neurodegenerative Diseases [MESH:D019636] <24> | (11|12) |
(12|4|0) |
| - 1: | Cranial Nerve Diseases [MESH:D003389] <17> | (1|1) |
(1|0|0) |
| - 1: | Neurocutaneous Syndromes [MESH:D020752] <17> | (0|1) |
(0|0|0) |
| - 1: | Central Nervous System Diseases [MESH:D002493] <15> | (53|44) |
(57|16|3) |
| - 1: | Neuromuscular Diseases [MESH:D009468] <15> | (23|23) |
(24|10|3) |
| - 1: | Demyelinating Diseases [MESH:D003711] <13> | (3|3) |
(3|1|0) |
| - 1: | Autoimmune Diseases of the Nervous System [MESH:D020274] <12> | (3|3) |
(4|1|0) |
| - 1: | Autonomic Nervous System Diseases [MESH:D001342] <11> | (0|0) |
(0|0|0) |
| - 1: | Neurotoxicity Syndromes [MESH:D020258] <7> | (1|2) |
(2|0|0) |
| - 1: | Nervous System Neoplasms [MESH:D009423] <6> | (0|1) |
(0|0|0) |
| - 1: | Sleep Wake Disorders [MESH:D012893] <4> | (0|0) |
(0|0|0) |
| - 1: | Trauma, Nervous System [MESH:D020196] <4> | (5|3) |
(5|1|0) |
| - 1: | Chronobiology Disorders [MESH:D021081] <3> | (2|1) |
(2|0|0) |
| - 1: | Restless Legs Syndrome [MESH:D012148] <3> | (0|0) |
(0|0|0) |
| - 1: | Alpha-Methylacyl-CoA Racemase Deficiency [MESH:C565768] | (0|0) |
(0|0|0) |
| - 1: | Congenital Cataracts, Facial Dysmorphism, And Neuropathy [MESH:C565822] | (0|0) |
(0|0|0) |
| - 1: | Marcus Gunn phenomenon [MESH:C535908] | (0|0) |
(0|0|0) |
| - 1: | NEUROLOGIC, ENDOCRINE, AND PANCREATIC DISEASE, MULTISYSTEM, INFANTILE-ONSET [OMIM:616263] | (0|0) |
(0|0|0) |
| - 1: | Neurologic Disease, Infantile Multisystem, with Osseous Fragility [MESH:C564954] | (0|0) |
(0|0|0) |
| - 1: | Neuronal intestinal pseudoobstruction [MESH:C537394] | (0|0) |
(0|0|0) |
| - 1: | Norrie disease [MESH:C537849] | (0|0) |
(0|0|0) |
| - 1: | Polyglucosan Body Disease, Adult Form [MESH:C564878] | (0|0) |
(0|0|0) |
| - 1: | Roy Maroteaux Kremp syndrome [MESH:C535875] | (0|0) |
(0|0|0) |
| - 1: | Tang Hsi Ryu syndrome [MESH:C536897] | (0|0) |
(0|0|0) |
| - 1: | Trifunctional Protein Deficiency With Myopathy And Neuropathy [MESH:C566945] | (0|0) |
(0|0|0) |
Jump to [ Top · Hierarchy ]
Superfamily( show details)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| tRNA-intron endonuclease catalytic domain-like | 0 | DIRECT |
| ADC-like | 0 | DIRECT |
| TK C-terminal domain-like | 0 | DIRECT |
| Proton glutamate symport protein | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Methylglyoxal synthase-like | 0 | DIRECT |
| Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | DIRECT |
| Flavoproteins | 0 | DIRECT |
| Synuclein | 0 | DIRECT |
| Voltage-gated potassium channels | 0.00000001802 | DIRECT |
| Nicotinic receptor ligand binding domain-like | 0.000003719 | DIRECT |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.000003719 | DIRECT |
| Periplasmic binding protein-like I | 0.003051 | INHERITED FROM: Epilepsy |
| Class II aaRS and biotin synthetases | 0.004451 | INHERITED FROM: Hereditary Sensory and Motor Neuropathy || Polyneuropathies |
| Thiamin diphosphate-binding fold (THDP-binding) | 0.01834 | INHERITED FROM: Brain Diseases, Metabolic |
| A DNA-binding domain in eukaryotic transcription factors | 0.0227 | INHERITED FROM: Status Epilepticus |
| Class II aaRS ABD-related | 0.02474 | INHERITED FROM: Neuromuscular Diseases |
| TNF receptor-like | 0.0259 | INHERITED FROM: Craniocerebral Trauma || Brain Injuries || Trauma, Nervous System |
| Nucleotidylyl transferase | 0.03847 | INHERITED FROM: Polyneuropathies |
| Single hybrid motif | 0.04146 | INHERITED FROM: Brain Diseases, Metabolic || Brain Diseases |
| Tubulin nucleotide-binding domain-like | 0.04349 | INHERITED FROM: Nervous System Malformations || Malformations of Cortical Development |
| Tubulin C-terminal domain-like | 0.04349 | INHERITED FROM: Nervous System Malformations || Malformations of Cortical Development |
| S15/NS1 RNA-binding domain | 0.05304 | INHERITED FROM: Neuromuscular Diseases || Nervous System Malformations || Charcot-Marie-Tooth Disease || Hereditary Sensory and Motor Neuropathy || Peripheral Nervous System Diseases || Polyneuropathies || Heredodegenerative Disorders, Nervous System |
| Restriction endonuclease-like | 0.05304 | INHERITED FROM: Neuromuscular Diseases |
| FAD/NAD(P)-binding domain | 0.06168 | INHERITED FROM: Huntington Disease |
| GST C-terminal domain-like | 0.07145 | INHERITED FROM: Neurodegenerative Diseases |
| Myosin rod fragments | 0.07153 | INHERITED FROM: Neuromuscular Diseases || Muscular Diseases |
| Leucine zipper domain | 0.07312 | INHERITED FROM: Infarction, Middle Cerebral Artery || Brain Ischemia || Trauma, Nervous System || Cerebral Arterial Diseases || Status Epilepticus |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.0763 | INHERITED FROM: Polyneuropathies |
| Protein kinase-like (PK-like) | 0.07681 | INHERITED FROM: Facial Nerve Diseases || Hyperalgesia |
| Family A G protein-coupled receptor-like | 0.07875 | INHERITED FROM: Hyperalgesia || Seizures || Memory Disorders || Pain || Neurologic Manifestations |
| POZ domain | 0.07886 | INHERITED FROM: Myopathies, Nemaline |
| Toll/Interleukin receptor TIR domain | 0.08393 | INHERITED FROM: Craniocerebral Trauma || Brain Injuries || Trauma, Nervous System |
| PYP-like sensor domain (PAS domain) | 0.09105 | INHERITED FROM: Chronobiology Disorders |
| 4-helical cytokines | 0.09773 | INHERITED FROM: Demyelinating Diseases || Craniocerebral Trauma || Infarction, Middle Cerebral Artery || Amnesia || Trauma, Nervous System || Autoimmune Diseases of the Nervous System |
| (Trans)glycosidases | 0.1023 | INHERITED FROM: Brain Diseases, Metabolic || Lysosomal Storage Diseases, Nervous System |
| Riboflavin synthase domain-like | 0.1225 | INHERITED FROM: Stroke || Brain Ischemia |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.1225 | INHERITED FROM: Stroke || Brain Ischemia |
| Bromodomain | 0.1227 | INHERITED FROM: Neurobehavioral Manifestations |
| Calcium ATPase, transmembrane domain M | 0.1238 | INHERITED FROM: Ataxia |
| Calcium ATPase, transduction domain A | 0.1238 | INHERITED FROM: Ataxia |
| BRK domain-like | 0.1313 | INHERITED FROM: Intellectual Disability |
| Cytokine | 0.1334 | INHERITED FROM: Craniocerebral Trauma || Brain Ischemia || Myositis || Epilepsy, Generalized || Cerebrovascular Disorders |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.1344 | INHERITED FROM: Ataxia |
| Thioredoxin-like | 0.1662 | INHERITED FROM: Down Syndrome |
| HAD-like | 0.1727 | INHERITED FROM: Ataxia |
| Tropomyosin | 0.1766 | INHERITED FROM: Arthrogryposis |
| GroEL equatorial domain-like | 0.1922 | INHERITED FROM: Hypothalamic Diseases || Bardet-Biedl Syndrome |
| Chaperone J-domain | 0.195 | INHERITED FROM: Cerebellar Ataxia |
| Serine protease inhibitors | 0.2092 | INHERITED FROM: Hearing Disorders || Hearing Loss |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.2092 | INHERITED FROM: Cerebellar Diseases || Spinocerebellar Degenerations || Ataxia || Spinocerebellar Ataxia 17 || Spinal Cord Diseases || Cerebellar Ataxia || Spinocerebellar Ataxias |
| Translation proteins | 0.2476 | INHERITED FROM: Spasms, Infantile |
| DEATH domain | 0.2499 | INHERITED FROM: Cerebrovascular Disorders |
| Actin-like ATPase domain | 0.267 | INHERITED FROM: Spinocerebellar Ataxia 17 |
| Kringle-like | 0.2759 | INHERITED FROM: Cerebral Infarction || Diabetic Neuropathies || Intracranial Thrombosis || Infarction, Middle Cerebral Artery || Cerebral Hemorrhage || Brain Edema || Pain || Cerebral Arterial Diseases |
| vWA-like | 0.2915 | INHERITED FROM: Contracture || Scleroatonic muscular dystrophy || Bethlem myopathy |
| Integrin domains | 0.3038 | INHERITED FROM: Cerebral Hemorrhage |
| Bcl-2 inhibitors of programmed cell death | 0.3295 | INHERITED FROM: Intracranial Hemorrhages || Cerebral Hemorrhage |
| Caspase-like | 0.3397 | INHERITED FROM: Status Epilepticus |
| Kelch motif | 0.362 | INHERITED FROM: Myopathies, Structural, Congenital || Myopathies, Nemaline |
| NagB/RpiA/CoA transferase-like | 0.381 | INHERITED FROM: Leukoencephalopathies || Vanishing White Matter Leukodystrophy with Ovarian Failure |
| Hemopexin-like domain | 0.3993 | INHERITED FROM: Cerebral Hemorrhage |
| Hect, E3 ligase catalytic domain | 0.3993 | INHERITED FROM: Malformations of Cortical Development |
| Spectrin repeat | 0.4203 | INHERITED FROM: Muscular Dystrophies || Muscular Disorders, Atrophic |
| Cystine-knot cytokines | 0.4225 | INHERITED FROM: Epilepsy, Tonic-Clonic || Status Epilepticus |
| CalX-like | 0.4291 | INHERITED FROM: Seizures |
| Insulin-like | 0.4291 | INHERITED FROM: Tauopathies || Alzheimer Disease || Dementia |
| Homeodomain-like | 0.4915 | INHERITED FROM: Myotonic Dystrophy || Pituitary Diseases || Hypothalamic Diseases |
| Intermediate filament protein, coiled coil region | 0.5108 | INHERITED FROM: Amyotrophic lateral sclerosis 1 || Neurodegenerative Diseases |
| Interleukin 8-like chemokines | 0.5224 | INHERITED FROM: Heavy Metal Poisoning, Nervous System || Neurotoxicity Syndromes || Infarction, Middle Cerebral Artery || Cerebrovascular Disorders |
| MHC antigen-recognition domain | 0.5331 | INHERITED FROM: Demyelinating Diseases || Multiple Sclerosis || Leukoencephalopathies || Autoimmune Diseases of the Nervous System |
| PGBD-like | 0.5586 | INHERITED FROM: Cerebral Hemorrhage |
| RING/U-box | 0.5687 | INHERITED FROM: Zellweger Syndrome |
| Nucleotide-diphospho-sugar transferases | 0.5722 | INHERITED FROM: Walker-Warburg Syndrome || Malformations of Cortical Development, Group II || Cobblestone Lissencephaly || Lissencephaly |
| Nuclear receptor ligand-binding domain | 0.5831 | INHERITED FROM: Sciatic Neuropathy || Mononeuropathies |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.6404 | INHERITED FROM: Sciatic Neuropathy || Mononeuropathies |
| L domain-like | 0.6575 | INHERITED FROM: Lewy Body Disease |
| Calponin-homology domain, CH-domain | 0.6954 | INHERITED FROM: Muscular Dystrophies || Muscular Disorders, Atrophic |
| Immunoglobulin | 0.7577 | INHERITED FROM: Demyelinating Diseases || Leukoencephalopathies || Autoimmune Diseases of the Nervous System |
| PDZ domain-like | 0.7835 | INHERITED FROM: Deaf-Blind Disorders || Usher Syndromes |
| HLH, helix-loop-helix DNA-binding domain | 0.8549 | INHERITED FROM: Chronobiology Disorders |
| RNA-binding domain, RBD | 0.8916 | INHERITED FROM: Frontotemporal Lobar Degeneration |
| EF-hand | 0.8936 | INHERITED FROM: Vasospasm, Intracranial |
| Cadherin-like | 0.95 | INHERITED FROM: Malformations of Cortical Development, Group II |
| Metalloproteases ("zincins"), catalytic domain | 0.9691 | INHERITED FROM: Cerebral Hemorrhage |
| TSP-1 type 1 repeat | 0.9825 | INHERITED FROM: Meningitis |
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| tRNA-intron endonuclease catalytic domain-like | 0 | Direct |
| ADC-like | 0 | Direct |
| TK C-terminal domain-like | 0 | Direct |
| Proton glutamate symport protein | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| Methylglyoxal synthase-like | 0 | Direct |
| Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | Direct |
| Flavoproteins | 0 | Direct |
| Synuclein | 0 | Direct |
| Voltage-gated potassium channels | 0.00000001802 | Direct |
| Nicotinic receptor ligand binding domain-like | 0.000003719 | Direct |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.000003719 | Direct |
| Periplasmic binding protein-like I | 0.003051 | Inherited |
| Class II aaRS and biotin synthetases | 0.004451 | Inherited |
| Thiamin diphosphate-binding fold (THDP-binding) | 0.01834 | Inherited |
| A DNA-binding domain in eukaryotic transcription factors | 0.0227 | Inherited |
| Class II aaRS ABD-related | 0.02474 | Inherited |
| TNF receptor-like | 0.0259 | Inherited |
| Nucleotidylyl transferase | 0.03847 | Inherited |
| Single hybrid motif | 0.04146 | Inherited |
| Tubulin nucleotide-binding domain-like | 0.04349 | Inherited |
| Tubulin C-terminal domain-like | 0.04349 | Inherited |
| S15/NS1 RNA-binding domain | 0.05304 | Inherited |
| Restriction endonuclease-like | 0.05304 | Inherited |
| FAD/NAD(P)-binding domain | 0.06168 | Inherited |
| GST C-terminal domain-like | 0.07145 | Inherited |
| Myosin rod fragments | 0.07153 | Inherited |
| Leucine zipper domain | 0.07312 | Inherited |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.0763 | Inherited |
| Protein kinase-like (PK-like) | 0.07681 | Inherited |
| Family A G protein-coupled receptor-like | 0.07875 | Inherited |
| POZ domain | 0.07886 | Inherited |
| Toll/Interleukin receptor TIR domain | 0.08393 | Inherited |
| PYP-like sensor domain (PAS domain) | 0.09105 | Inherited |
| 4-helical cytokines | 0.09773 | Inherited |
| (Trans)glycosidases | 0.1023 | Inherited |
| Riboflavin synthase domain-like | 0.1225 | Inherited |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.1225 | Inherited |
| Bromodomain | 0.1227 | Inherited |
| Calcium ATPase, transmembrane domain M | 0.1238 | Inherited |
| Calcium ATPase, transduction domain A | 0.1238 | Inherited |
| BRK domain-like | 0.1313 | Inherited |
| Cytokine | 0.1334 | Inherited |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.1344 | Inherited |
| Thioredoxin-like | 0.1662 | Inherited |
| HAD-like | 0.1727 | Inherited |
| Tropomyosin | 0.1766 | Inherited |
| GroEL equatorial domain-like | 0.1922 | Inherited |
| Chaperone J-domain | 0.195 | Inherited |
| Serine protease inhibitors | 0.2092 | Inherited |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.2092 | Inherited |
| Translation proteins | 0.2476 | Inherited |
| DEATH domain | 0.2499 | Inherited |
| Actin-like ATPase domain | 0.267 | Inherited |
| Kringle-like | 0.2759 | Inherited |
| vWA-like | 0.2915 | Inherited |
| Integrin domains | 0.3038 | Inherited |
| Bcl-2 inhibitors of programmed cell death | 0.3295 | Inherited |
| Caspase-like | 0.3397 | Inherited |
| Kelch motif | 0.362 | Inherited |
| NagB/RpiA/CoA transferase-like | 0.381 | Inherited |
| Hemopexin-like domain | 0.3993 | Inherited |
| Hect, E3 ligase catalytic domain | 0.3993 | Inherited |
| Spectrin repeat | 0.4203 | Inherited |
| Cystine-knot cytokines | 0.4225 | Inherited |
| CalX-like | 0.4291 | Inherited |
| Insulin-like | 0.4291 | Inherited |
| Homeodomain-like | 0.4915 | Inherited |
| Intermediate filament protein, coiled coil region | 0.5108 | Inherited |
| Interleukin 8-like chemokines | 0.5224 | Inherited |
| MHC antigen-recognition domain | 0.5331 | Inherited |
| PGBD-like | 0.5586 | Inherited |
| RING/U-box | 0.5687 | Inherited |
| Nucleotide-diphospho-sugar transferases | 0.5722 | Inherited |
| Nuclear receptor ligand-binding domain | 0.5831 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.6404 | Inherited |
| L domain-like | 0.6575 | Inherited |
| Calponin-homology domain, CH-domain | 0.6954 | Inherited |
| Immunoglobulin | 0.7577 | Inherited |
| PDZ domain-like | 0.7835 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.8549 | Inherited |
| RNA-binding domain, RBD | 0.8916 | Inherited |
| EF-hand | 0.8936 | Inherited |
| Cadherin-like | 0.95 | Inherited |
| Metalloproteases ("zincins"), catalytic domain | 0.9691 | Inherited |
| TSP-1 type 1 repeat | 0.9825 | Inherited |
LINKTO: Domain2BO Download and Domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Family( show details)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0 | DIRECT |
| alpha-Amylases, C-terminal beta-sheet domain | 0 | DIRECT |
| tRNA-intron endonuclease catalytic domain-like | 0 | DIRECT |
| Anticodon-binding domain | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain | 0 | DIRECT |
| ZZ domain | 0 | DIRECT |
| Proton glutamate symport protein | 0 | DIRECT |
| Synuclein | 0 | DIRECT |
| IF2B-like | 0 | DIRECT |
| Cytochrome p450 reductase N-terminal domain-like | 0 | DIRECT |
| EF-G/eEF-2 domains III and V | 0 | DIRECT |
| NADPH-cytochrome p450 reductase-like | 0 | DIRECT |
| Neurotrophin | 0 | DIRECT |
| Adenosine/AMP deaminase | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.000002272 | DIRECT |
| Nicotinic receptor ligand binding domain-like | 0.000002272 | DIRECT |
| Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0.0005175 | DIRECT |
| Voltage-gated potassium channels | 0.0007338 | DIRECT |
| Tetramerization domain of potassium channels | 0.002303 | INHERITED FROM: Epileptic Syndromes |
| L-arabinose binding protein-like | 0.002445 | INHERITED FROM: Epilepsy |
| Rhodopsin-like | 0.01421 | INHERITED FROM: Hyperalgesia || Seizures || Memory Disorders || Encephalitis, Viral || Infectious Encephalitis || Pain || Neurologic Manifestations |
| A DNA-binding domain in eukaryotic transcription factors | 0.01833 | INHERITED FROM: Status Epilepticus |
| Anticodon-binding domain of Class II aaRS | 0.02013 | INHERITED FROM: Neuromuscular Diseases |
| Interleukin-1 (IL-1) | 0.02013 | INHERITED FROM: Hyperalgesia || Heavy Metal Poisoning, Nervous System || Neurotoxicity Syndromes || Craniocerebral Trauma || Somatosensory Disorders || Brain Injuries || Sensation Disorders || Brain Ischemia || Myositis || Trauma, Nervous System || Cerebrovascular Disorders |
| Extended AAA-ATPase domain | 0.02037 | INHERITED FROM: Hearing Loss |
| Meta-cation ATPase, catalytic domain P | 0.02154 | INHERITED FROM: Ataxia || Paralysis |
| Phosphate binding protein-like | 0.02179 | INHERITED FROM: Epileptic Syndromes |
| Motor proteins | 0.02909 | INHERITED FROM: Hearing Disorders || Hearing Loss || Malformations of Cortical Development, Group I |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.03423 | INHERITED FROM: Polyneuropathies |
| Biotinyl/lipoyl-carrier proteins and domains | 0.03423 | INHERITED FROM: Brain Diseases, Metabolic || Brain Diseases |
| Tubulin, C-terminal domain | 0.03633 | INHERITED FROM: Nervous System Malformations || Malformations of Cortical Development |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.03633 | INHERITED FROM: Ataxia |
| Tubulin, GTPase domain | 0.03633 | INHERITED FROM: Nervous System Malformations || Malformations of Cortical Development |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.03633 | INHERITED FROM: Polyneuropathies |
| Long-chain cytokines | 0.03633 | INHERITED FROM: Brain Diseases |
| a tRNA synthase domain | 0.04354 | INHERITED FROM: Neuromuscular Diseases || Nervous System Malformations || Charcot-Marie-Tooth Disease || Hereditary Sensory and Motor Neuropathy || Peripheral Nervous System Diseases || Polyneuropathies || Heredodegenerative Disorders, Nervous System || Neurodegenerative Diseases |
| Myotubularin-like phosphatases | 0.05871 | INHERITED FROM: Neuromuscular Diseases || Charcot-Marie-Tooth Disease || Hereditary Sensory and Motor Neuropathy || Polyneuropathies |
| Leucine zipper domain | 0.06326 | INHERITED FROM: Cerebral Infarction || Infarction, Middle Cerebral Artery || Brain Ischemia || Trauma, Nervous System || Cerebral Arterial Diseases || Status Epilepticus |
| Myosin rod fragments | 0.06334 | INHERITED FROM: Neuromuscular Diseases || Muscular Diseases |
| Integrin A (or I) domain | 0.06893 | INHERITED FROM: Contracture || Scleroatonic muscular dystrophy || Bethlem myopathy |
| Glutathione S-transferase (GST), C-terminal domain | 0.09939 | INHERITED FROM: Neurodegenerative Diseases |
| Bromodomain | 0.1085 | INHERITED FROM: Intellectual Disability || Neurobehavioral Manifestations |
| Calcium ATPase, transduction domain A | 0.109 | INHERITED FROM: Ataxia |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.112 | INHERITED FROM: Malformations of Cortical Development |
| BRK domain-like | 0.1135 | INHERITED FROM: Intellectual Disability |
| L domain | 0.115 | INHERITED FROM: Neuromuscular Diseases |
| Tropomyosin | 0.1558 | INHERITED FROM: Arthrogryposis |
| Toll/Interleukin receptor TIR domain | 0.1577 | INHERITED FROM: Craniocerebral Trauma || Brain Injuries || Trauma, Nervous System |
| Actin/HSP70 | 0.1577 | INHERITED FROM: Spinocerebellar Ataxia 17 || Cerebellar Ataxia || Spinocerebellar Ataxias |
| Protein kinases, catalytic subunit | 0.1601 | INHERITED FROM: Facial Nerve Diseases || Hyperalgesia |
| Chaperone J-domain | 0.1741 | INHERITED FROM: Cerebellar Ataxia |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.1867 | INHERITED FROM: Dyskinesias || Cerebellar Diseases || Spinocerebellar Degenerations || Ataxia || Spinocerebellar Ataxia 17 || Spinal Cord Diseases || Cerebellar Ataxia || Spinocerebellar Ataxias |
| Interferons/interleukin-10 (IL-10) | 0.2401 | INHERITED FROM: Demyelinating Diseases || Multiple Sclerosis || Leukoencephalopathies || Autoimmune Diseases of the Nervous System |
| Caspase catalytic domain | 0.2401 | INHERITED FROM: Status Epilepticus |
| p120GAP domain-like | 0.268 | INHERITED FROM: Nervous System Neoplasms |
| FHA domain | 0.2803 | INHERITED FROM: Ataxia || Peripheral Nervous System Diseases |
| Integrin domains | 0.2803 | INHERITED FROM: Cerebral Hemorrhage |
| Bcl-2 inhibitors of programmed cell death | 0.3019 | INHERITED FROM: Intracranial Hemorrhages || Cerebral Hemorrhage |
| Spectrin repeat | 0.338 | INHERITED FROM: Muscular Dystrophies || Muscular Disorders, Atrophic |
| Kelch motif | 0.338 | INHERITED FROM: Myopathies, Structural, Congenital || Myopathies, Nemaline |
| Homeodomain | 0.3435 | INHERITED FROM: Myotonic Disorders || Myotonic Dystrophy || Pituitary Diseases || Hypothalamic Diseases |
| Kringle modules | 0.3477 | INHERITED FROM: Cerebral Infarction || Intracranial Thrombosis || Stroke || Infarction, Middle Cerebral Artery || Intracranial Embolism and Thrombosis || Pain || Cerebral Arterial Diseases |
| Hect, E3 ligase catalytic domain | 0.3746 | INHERITED FROM: Malformations of Cortical Development |
| Hemopexin-like domain | 0.3746 | INHERITED FROM: Cerebral Hemorrhage |
| CalX-beta domain | 0.4027 | INHERITED FROM: Seizures |
| Insulin-like | 0.4027 | INHERITED FROM: Tauopathies || Alzheimer Disease || Dementia |
| Synaptotagmin-like (S variant) | 0.4164 | INHERITED FROM: Spinocerebellar Degenerations |
| C1 set domains (antibody constant domain-like) | 0.4536 | INHERITED FROM: Demyelinating Diseases || Multiple Sclerosis || Leukoencephalopathies || Autoimmune Diseases of the Nervous System |
| Nuclear receptor | 0.4844 | INHERITED FROM: Sciatic Neuropathy || Mononeuropathies |
| Intermediate filament protein, coiled coil region | 0.4931 | INHERITED FROM: Amyotrophic lateral sclerosis 1 || Neurodegenerative Diseases |
| Interleukin 8-like chemokines | 0.5026 | INHERITED FROM: Heavy Metal Poisoning, Nervous System || Neurotoxicity Syndromes || Infarction, Middle Cerebral Artery || Cerebrovascular Disorders |
| MHC antigen-recognition domain | 0.512 | INHERITED FROM: Demyelinating Diseases || Multiple Sclerosis || Leukoencephalopathies || Autoimmune Diseases of the Nervous System |
| S100 proteins | 0.5193 | INHERITED FROM: Vasospasm, Intracranial || Cerebrovascular Disorders |
| MMP N-terminal domain | 0.5355 | INHERITED FROM: Cerebral Hemorrhage |
| G proteins | 0.5584 | INHERITED FROM: Nevus, Sebaceous of Jadassohn || Neurocutaneous Syndromes |
| Nuclear receptor ligand-binding domain | 0.5657 | INHERITED FROM: Sciatic Neuropathy || Mononeuropathies |
| Matrix metalloproteases, catalytic domain | 0.6678 | INHERITED FROM: Cerebral Hemorrhage |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.6751 | INHERITED FROM: Hyperalgesia || Somatosensory Disorders |
| Calponin-homology domain, CH-domain | 0.6786 | INHERITED FROM: Muscular Dystrophies || Muscular Disorders, Atrophic |
| Canonical RBD | 0.7198 | INHERITED FROM: Muscular Dystrophies || Muscular Disorders, Atrophic || Frontotemporal Lobar Degeneration |
| PHD domain | 0.754 | INHERITED FROM: Neurobehavioral Manifestations |
| PDZ domain | 0.8061 | INHERITED FROM: Blindness || Deaf-Blind Disorders || Usher Syndromes |
| HLH, helix-loop-helix DNA-binding domain | 0.8437 | INHERITED FROM: Chronobiology Disorders |
| Eukaryotic proteases | 0.9619 | INHERITED FROM: Intracranial Embolism and Thrombosis |
| TSP-1 type 1 repeat | 0.9749 | INHERITED FROM: Meningitis |
| Pleckstrin-homology domain (PH domain) | 1 | INHERITED FROM: Charcot-Marie-Tooth Disease |
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0 | Direct |
| alpha-Amylases, C-terminal beta-sheet domain | 0 | Direct |
| tRNA-intron endonuclease catalytic domain-like | 0 | Direct |
| Anticodon-binding domain | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain | 0 | Direct |
| ZZ domain | 0 | Direct |
| Proton glutamate symport protein | 0 | Direct |
| Synuclein | 0 | Direct |
| IF2B-like | 0 | Direct |
| Cytochrome p450 reductase N-terminal domain-like | 0 | Direct |
| EF-G/eEF-2 domains III and V | 0 | Direct |
| NADPH-cytochrome p450 reductase-like | 0 | Direct |
| Neurotrophin | 0 | Direct |
| Adenosine/AMP deaminase | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.000002272 | Direct |
| Nicotinic receptor ligand binding domain-like | 0.000002272 | Direct |
| Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0.0005175 | Direct |
| Voltage-gated potassium channels | 0.0007338 | Direct |
| Tetramerization domain of potassium channels | 0.002303 | Inherited |
| L-arabinose binding protein-like | 0.002445 | Inherited |
| Rhodopsin-like | 0.01421 | Inherited |
| A DNA-binding domain in eukaryotic transcription factors | 0.01833 | Inherited |
| Anticodon-binding domain of Class II aaRS | 0.02013 | Inherited |
| Interleukin-1 (IL-1) | 0.02013 | Inherited |
| Extended AAA-ATPase domain | 0.02037 | Inherited |
| Meta-cation ATPase, catalytic domain P | 0.02154 | Inherited |
| Phosphate binding protein-like | 0.02179 | Inherited |
| Motor proteins | 0.02909 | Inherited |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.03423 | Inherited |
| Biotinyl/lipoyl-carrier proteins and domains | 0.03423 | Inherited |
| Tubulin, C-terminal domain | 0.03633 | Inherited |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.03633 | Inherited |
| Tubulin, GTPase domain | 0.03633 | Inherited |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.03633 | Inherited |
| Long-chain cytokines | 0.03633 | Inherited |
| a tRNA synthase domain | 0.04354 | Inherited |
| Myotubularin-like phosphatases | 0.05871 | Inherited |
| Leucine zipper domain | 0.06326 | Inherited |
| Myosin rod fragments | 0.06334 | Inherited |
| Integrin A (or I) domain | 0.06893 | Inherited |
| Glutathione S-transferase (GST), C-terminal domain | 0.09939 | Inherited |
| Bromodomain | 0.1085 | Inherited |
| Calcium ATPase, transduction domain A | 0.109 | Inherited |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.112 | Inherited |
| BRK domain-like | 0.1135 | Inherited |
| L domain | 0.115 | Inherited |
| Tropomyosin | 0.1558 | Inherited |
| Toll/Interleukin receptor TIR domain | 0.1577 | Inherited |
| Actin/HSP70 | 0.1577 | Inherited |
| Protein kinases, catalytic subunit | 0.1601 | Inherited |
| Chaperone J-domain | 0.1741 | Inherited |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.1867 | Inherited |
| Interferons/interleukin-10 (IL-10) | 0.2401 | Inherited |
| Caspase catalytic domain | 0.2401 | Inherited |
| p120GAP domain-like | 0.268 | Inherited |
| FHA domain | 0.2803 | Inherited |
| Integrin domains | 0.2803 | Inherited |
| Bcl-2 inhibitors of programmed cell death | 0.3019 | Inherited |
| Spectrin repeat | 0.338 | Inherited |
| Kelch motif | 0.338 | Inherited |
| Homeodomain | 0.3435 | Inherited |
| Kringle modules | 0.3477 | Inherited |
| Hect, E3 ligase catalytic domain | 0.3746 | Inherited |
| Hemopexin-like domain | 0.3746 | Inherited |
| CalX-beta domain | 0.4027 | Inherited |
| Insulin-like | 0.4027 | Inherited |
| Synaptotagmin-like (S variant) | 0.4164 | Inherited |
| C1 set domains (antibody constant domain-like) | 0.4536 | Inherited |
| Nuclear receptor | 0.4844 | Inherited |
| Intermediate filament protein, coiled coil region | 0.4931 | Inherited |
| Interleukin 8-like chemokines | 0.5026 | Inherited |
| MHC antigen-recognition domain | 0.512 | Inherited |
| S100 proteins | 0.5193 | Inherited |
| MMP N-terminal domain | 0.5355 | Inherited |
| G proteins | 0.5584 | Inherited |
| Nuclear receptor ligand-binding domain | 0.5657 | Inherited |
| Matrix metalloproteases, catalytic domain | 0.6678 | Inherited |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.6751 | Inherited |
| Calponin-homology domain, CH-domain | 0.6786 | Inherited |
| Canonical RBD | 0.7198 | Inherited |
| PHD domain | 0.754 | Inherited |
| PDZ domain | 0.8061 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.8437 | Inherited |
| Eukaryotic proteases | 0.9619 | Inherited |
| TSP-1 type 1 repeat | 0.9749 | Inherited |
| Pleckstrin-homology domain (PH domain) | 1 | Inherited |
LINKTO: Domain2BO Download and Domain2BO Algorithm
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Supra-domain (Single)( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| TK C-terminal domain-like | 0 | DIRECT |
| ADC-like | 0 | DIRECT |
| Methylglyoxal synthase-like | 0 | DIRECT |
| Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | DIRECT |
| Synuclein | 0 | DIRECT |
| Flavoproteins | 0 | DIRECT |
| tRNA-intron endonuclease catalytic domain-like | 0 | DIRECT |
| Proton glutamate symport protein | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Voltage-gated potassium channels | 0.00000000749 | DIRECT |
| Nicotinic receptor ligand binding domain-like | 0.000001754 | DIRECT |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.000001754 | DIRECT |
| Periplasmic binding protein-like I | 0.002117 | INHERITED FROM: Epilepsy |
| Class II aaRS and biotin synthetases | 0.003135 | INHERITED FROM: Polyneuropathies || Hereditary Sensory and Motor Neuropathy |
| CoA-dependent acyltransferases | 0.006527 | INHERITED FROM: Brain Diseases, Metabolic |
| Thiamin diphosphate-binding fold (THDP-binding) | 0.01376 | INHERITED FROM: Brain Diseases, Metabolic |
| A DNA-binding domain in eukaryotic transcription factors | 0.01728 | INHERITED FROM: Status Epilepticus |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.01896 | INHERITED FROM: Brain Diseases |
| Class II aaRS ABD-related | 0.01896 | INHERITED FROM: Neuromuscular Diseases |
| TNF receptor-like | 0.01993 | INHERITED FROM: Craniocerebral Trauma || Trauma, Nervous System || Brain Injuries |
| Nucleotidylyl transferase | 0.03026 | INHERITED FROM: Polyneuropathies |
| Single hybrid motif | 0.03274 | INHERITED FROM: Brain Diseases, Metabolic || Brain Diseases |
| Tubulin C-terminal domain-like | 0.03452 | INHERITED FROM: Nervous System Malformations || Malformations of Cortical Development |
| Tubulin nucleotide-binding domain-like | 0.03452 | INHERITED FROM: Nervous System Malformations || Malformations of Cortical Development |
| S15/NS1 RNA-binding domain | 0.04241 | INHERITED FROM: Polyneuropathies || Charcot-Marie-Tooth Disease || Neuromuscular Diseases || Hereditary Sensory and Motor Neuropathy || Heredodegenerative Disorders, Nervous System || Peripheral Nervous System Diseases || Nervous System Malformations || Neurodegenerative Diseases |
| Restriction endonuclease-like | 0.04241 | INHERITED FROM: Neuromuscular Diseases |
| FAD/NAD(P)-binding domain | 0.04997 | INHERITED FROM: Chorea || Huntington Disease |
| GST C-terminal domain-like | 0.05815 | INHERITED FROM: Neurodegenerative Diseases |
| Myosin rod fragments | 0.05819 | INHERITED FROM: Neuromuscular Diseases || Muscular Diseases |
| Leucine zipper domain | 0.05964 | INHERITED FROM: Cerebral Arterial Diseases || Status Epilepticus || Cerebral Infarction || Trauma, Nervous System || Brain Ischemia || Infarction, Middle Cerebral Artery |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.06239 | INHERITED FROM: Polyneuropathies |
| Protein kinase-like (PK-like) | 0.06277 | INHERITED FROM: Hyperalgesia || Facial Nerve Diseases |
| Family A G protein-coupled receptor-like | 0.06456 | INHERITED FROM: Pain || Seizures || Infectious Encephalitis || Encephalitis, Viral || Hyperalgesia || Neurologic Manifestations || Memory Disorders |
| POZ domain | 0.06466 | INHERITED FROM: Myopathies, Nemaline |
| Toll/Interleukin receptor TIR domain | 0.06911 | INHERITED FROM: Craniocerebral Trauma || Trauma, Nervous System || Brain Diseases || Brain Injuries |
| PYP-like sensor domain (PAS domain) | 0.07521 | INHERITED FROM: Chronobiology Disorders |
| 4-helical cytokines | 0.0812 | INHERITED FROM: Pain || Headache || Autoimmune Diseases of the Nervous System || Craniocerebral Trauma || Demyelinating Diseases || Trauma, Nervous System || Infarction, Middle Cerebral Artery || Amnesia |
| (Trans)glycosidases | 0.08537 | INHERITED FROM: Brain Diseases, Metabolic || Lysosomal Storage Diseases, Nervous System |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.1035 | INHERITED FROM: Stroke || Brain Ischemia |
| Riboflavin synthase domain-like | 0.1035 | INHERITED FROM: Stroke || Brain Ischemia |
| Bromodomain | 0.1036 | INHERITED FROM: Neurobehavioral Manifestations |
| Calcium ATPase, transmembrane domain M | 0.1047 | INHERITED FROM: Paralysis || Ataxia |
| Calcium ATPase, transduction domain A | 0.1047 | INHERITED FROM: Paralysis || Ataxia |
| BRK domain-like | 0.1114 | INHERITED FROM: Intellectual Disability |
| Cytokine | 0.1131 | INHERITED FROM: Heavy Metal Poisoning, Nervous System || Epilepsy, Generalized || Craniocerebral Trauma || Trauma, Nervous System || Sensation Disorders || Brain Injuries || Brain Ischemia || Cerebrovascular Disorders || Myositis |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.1141 | INHERITED FROM: Paralysis || Ataxia |
| Thioredoxin-like | 0.1426 | INHERITED FROM: Down Syndrome |
| HAD-like | 0.1487 | INHERITED FROM: Ataxia |
| Tropomyosin | 0.1525 | INHERITED FROM: Arthrogryposis |
| GroEL equatorial domain-like | 0.167 | INHERITED FROM: Hypothalamic Diseases || Bardet-Biedl Syndrome |
| Chaperone J-domain | 0.1695 | INHERITED FROM: Cerebellar Ataxia |
| Serine protease inhibitors | 0.1831 | INHERITED FROM: Hearing Disorders || Hearing Loss |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.1831 | INHERITED FROM: Cerebellar Diseases || Spinocerebellar Ataxias || Ataxia || Dyskinesias || Spinal Cord Diseases || Cerebellar Ataxia || Spinocerebellar Ataxia 17 || Spinocerebellar Degenerations |
| Translation proteins | 0.2195 | INHERITED FROM: Spasms, Infantile |
| DEATH domain | 0.2217 | INHERITED FROM: Cerebrovascular Disorders |
| Actin-like ATPase domain | 0.2378 | INHERITED FROM: Spinocerebellar Ataxia 17 |
| Kringle-like | 0.2455 | INHERITED FROM: Brain Edema || Cerebral Arterial Diseases || Pain || Intracranial Thrombosis || Cerebral Infarction || Diabetic Neuropathies || Cerebral Hemorrhage || Alzheimer Disease || Infarction, Middle Cerebral Artery |
| vWA-like | 0.2601 | INHERITED FROM: Bethlem myopathy || Scleroatonic muscular dystrophy || Contracture |
| Integrin domains | 0.2718 | INHERITED FROM: Cerebral Hemorrhage |
| Bcl-2 inhibitors of programmed cell death | 0.2967 | INHERITED FROM: Intracranial Hemorrhages || Cerebral Hemorrhage |
| Caspase-like | 0.307 | INHERITED FROM: Status Epilepticus |
| Kelch motif | 0.3289 | INHERITED FROM: Myopathies, Structural, Congenital || Myopathies, Nemaline |
| NagB/RpiA/CoA transferase-like | 0.3473 | INHERITED FROM: Vanishing White Matter Leukodystrophy with Ovarian Failure || Leukoencephalopathies |
| Hemopexin-like domain | 0.3655 | INHERITED FROM: Cerebral Hemorrhage |
| Hect, E3 ligase catalytic domain | 0.3655 | INHERITED FROM: Malformations of Cortical Development |
| Spectrin repeat | 0.3857 | INHERITED FROM: Muscular Disorders, Atrophic || Muscular Dystrophies |
| Cystine-knot cytokines | 0.3879 | INHERITED FROM: Status Epilepticus || Epilepsy, Tonic-Clonic |
| Insulin-like | 0.3945 | INHERITED FROM: Dementia || Tauopathies || Alzheimer Disease |
| CalX-like | 0.3945 | INHERITED FROM: Seizures |
| Homeodomain-like | 0.4572 | INHERITED FROM: Pituitary Diseases || Hypothalamic Diseases || Myotonic Dystrophy |
| Intermediate filament protein, coiled coil region | 0.4772 | INHERITED FROM: Amyotrophic lateral sclerosis 1 || Neurodegenerative Diseases |
| Interleukin 8-like chemokines | 0.4888 | INHERITED FROM: Heavy Metal Poisoning, Nervous System || Cerebral Arterial Diseases || Cerebral Infarction || Neurotoxicity Syndromes || Infarction, Middle Cerebral Artery || Cerebrovascular Disorders |
| MHC antigen-recognition domain | 0.4995 | INHERITED FROM: Multiple Sclerosis || Autoimmune Diseases of the Nervous System || Demyelinating Diseases || Leukoencephalopathies |
| PGBD-like | 0.5247 | INHERITED FROM: Cerebral Hemorrhage |
| RING/U-box | 0.5349 | INHERITED FROM: Zellweger Syndrome |
| Nucleotide-diphospho-sugar transferases | 0.5382 | INHERITED FROM: Cobblestone Lissencephaly || Lissencephaly || Malformations of Cortical Development, Group II || Walker-Warburg Syndrome |
| Nuclear receptor ligand-binding domain | 0.549 | INHERITED FROM: Sciatic Neuropathy || Mononeuropathies |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.6069 | INHERITED FROM: Sciatic Neuropathy || Mononeuropathies |
| L domain-like | 0.6243 | INHERITED FROM: Lewy Body Disease |
| Ribonuclease H-like | 0.6574 | INHERITED FROM: Autoimmune Diseases of the Nervous System |
| Calponin-homology domain, CH-domain | 0.6635 | INHERITED FROM: Muscular Disorders, Atrophic || Muscular Dystrophies |
| Immunoglobulin | 0.7279 | INHERITED FROM: Autoimmune Diseases of the Nervous System || Demyelinating Diseases || Leukoencephalopathies |
| PDZ domain-like | 0.7547 | INHERITED FROM: Deaf-Blind Disorders || Usher Syndromes |
| HLH, helix-loop-helix DNA-binding domain | 0.8306 | INHERITED FROM: Chronobiology Disorders |
| Cysteine-rich domain | 0.833 | INHERITED FROM: Hyperalgesia || Somatosensory Disorders |
| RNA-binding domain, RBD | 0.8686 | INHERITED FROM: Frontotemporal Lobar Degeneration |
| EF-hand | 0.8708 | INHERITED FROM: Vasospasm, Intracranial |
| Trypsin-like serine proteases | 0.9221 | INHERITED FROM: Cerebral Arterial Diseases || Cerebral Infarction |
| Cadherin-like | 0.9325 | INHERITED FROM: Malformations of Cortical Development, Group II |
| Metalloproteases ("zincins"), catalytic domain | 0.9541 | INHERITED FROM: Diabetic Neuropathies || Cerebral Hemorrhage |
| TSP-1 type 1 repeat | 0.9691 | INHERITED FROM: Meningitis |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| TK C-terminal domain-like | 0 | Direct |
| ADC-like | 0 | Direct |
| Methylglyoxal synthase-like | 0 | Direct |
| Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | Direct |
| Synuclein | 0 | Direct |
| Flavoproteins | 0 | Direct |
| tRNA-intron endonuclease catalytic domain-like | 0 | Direct |
| Proton glutamate symport protein | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| Voltage-gated potassium channels | 0.00000000749 | Direct |
| Nicotinic receptor ligand binding domain-like | 0.000001754 | Direct |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.000001754 | Direct |
| Periplasmic binding protein-like I | 0.002117 | Inherited |
| Class II aaRS and biotin synthetases | 0.003135 | Inherited |
| CoA-dependent acyltransferases | 0.006527 | Inherited |
| Thiamin diphosphate-binding fold (THDP-binding) | 0.01376 | Inherited |
| A DNA-binding domain in eukaryotic transcription factors | 0.01728 | Inherited |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.01896 | Inherited |
| Class II aaRS ABD-related | 0.01896 | Inherited |
| TNF receptor-like | 0.01993 | Inherited |
| Nucleotidylyl transferase | 0.03026 | Inherited |
| Single hybrid motif | 0.03274 | Inherited |
| Tubulin C-terminal domain-like | 0.03452 | Inherited |
| Tubulin nucleotide-binding domain-like | 0.03452 | Inherited |
| S15/NS1 RNA-binding domain | 0.04241 | Inherited |
| Restriction endonuclease-like | 0.04241 | Inherited |
| FAD/NAD(P)-binding domain | 0.04997 | Inherited |
| GST C-terminal domain-like | 0.05815 | Inherited |
| Myosin rod fragments | 0.05819 | Inherited |
| Leucine zipper domain | 0.05964 | Inherited |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.06239 | Inherited |
| Protein kinase-like (PK-like) | 0.06277 | Inherited |
| Family A G protein-coupled receptor-like | 0.06456 | Inherited |
| POZ domain | 0.06466 | Inherited |
| Toll/Interleukin receptor TIR domain | 0.06911 | Inherited |
| PYP-like sensor domain (PAS domain) | 0.07521 | Inherited |
| 4-helical cytokines | 0.0812 | Inherited |
| (Trans)glycosidases | 0.08537 | Inherited |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.1035 | Inherited |
| Riboflavin synthase domain-like | 0.1035 | Inherited |
| Bromodomain | 0.1036 | Inherited |
| Calcium ATPase, transmembrane domain M | 0.1047 | Inherited |
| Calcium ATPase, transduction domain A | 0.1047 | Inherited |
| BRK domain-like | 0.1114 | Inherited |
| Cytokine | 0.1131 | Inherited |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.1141 | Inherited |
| Thioredoxin-like | 0.1426 | Inherited |
| HAD-like | 0.1487 | Inherited |
| Tropomyosin | 0.1525 | Inherited |
| GroEL equatorial domain-like | 0.167 | Inherited |
| Chaperone J-domain | 0.1695 | Inherited |
| Serine protease inhibitors | 0.1831 | Inherited |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.1831 | Inherited |
| Translation proteins | 0.2195 | Inherited |
| DEATH domain | 0.2217 | Inherited |
| Actin-like ATPase domain | 0.2378 | Inherited |
| Kringle-like | 0.2455 | Inherited |
| vWA-like | 0.2601 | Inherited |
| Integrin domains | 0.2718 | Inherited |
| Bcl-2 inhibitors of programmed cell death | 0.2967 | Inherited |
| Caspase-like | 0.307 | Inherited |
| Kelch motif | 0.3289 | Inherited |
| NagB/RpiA/CoA transferase-like | 0.3473 | Inherited |
| Hemopexin-like domain | 0.3655 | Inherited |
| Hect, E3 ligase catalytic domain | 0.3655 | Inherited |
| Spectrin repeat | 0.3857 | Inherited |
| Cystine-knot cytokines | 0.3879 | Inherited |
| Insulin-like | 0.3945 | Inherited |
| CalX-like | 0.3945 | Inherited |
| Homeodomain-like | 0.4572 | Inherited |
| Intermediate filament protein, coiled coil region | 0.4772 | Inherited |
| Interleukin 8-like chemokines | 0.4888 | Inherited |
| MHC antigen-recognition domain | 0.4995 | Inherited |
| PGBD-like | 0.5247 | Inherited |
| RING/U-box | 0.5349 | Inherited |
| Nucleotide-diphospho-sugar transferases | 0.5382 | Inherited |
| Nuclear receptor ligand-binding domain | 0.549 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.6069 | Inherited |
| L domain-like | 0.6243 | Inherited |
| Ribonuclease H-like | 0.6574 | Inherited |
| Calponin-homology domain, CH-domain | 0.6635 | Inherited |
| Immunoglobulin | 0.7279 | Inherited |
| PDZ domain-like | 0.7547 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.8306 | Inherited |
| Cysteine-rich domain | 0.833 | Inherited |
| RNA-binding domain, RBD | 0.8686 | Inherited |
| EF-hand | 0.8708 | Inherited |
| Trypsin-like serine proteases | 0.9221 | Inherited |
| Cadherin-like | 0.9325 | Inherited |
| Metalloproteases ("zincins"), catalytic domain | 0.9541 | Inherited |
| TSP-1 type 1 repeat | 0.9691 | Inherited |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Duplex) in N- to C-terminal order( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
52799,49562
52799 - (Phosphotyrosine protein) phosphatases II
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
54980,54211
54980 - EF-G C-terminal domain-like
54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
53300,53300
53300 - vWA-like
53300 - vWA-like | 0 | DIRECT |
47005,52777
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
52777 - CoA-dependent acyltransferases | 0 | DIRECT |
51230,47005
51230 - Single hybrid motif
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | DIRECT |
54211,54980
54211 - Ribosomal protein S5 domain 2-like
54980 - EF-G C-terminal domain-like | 0 | DIRECT |
52518,52922
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 0 | DIRECT |
48403,52540
48403 - Ankyrin repeat
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.000001754 | DIRECT |
47454,57959
47454 - A DNA-binding domain in eukaryotic transcription factors
57959 - Leucine zipper domain | 0.01728 | INHERITED FROM: Status Epilepticus |
53822,53850
53822 - Periplasmic binding protein-like I
53850 - Periplasmic binding protein-like II | 0.01896 | INHERITED FROM: Epileptic Syndromes || Intellectual Disability || Epilepsy |
51905,55424
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.01896 | INHERITED FROM: Brain Diseases |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.02016 | INHERITED FROM: Craniocerebral Trauma |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0.03274 | INHERITED FROM: Cerebral Arterial Diseases || Pain || Cerebral Infarction || Diabetic Neuropathies || Brain Diseases || Cerebral Hemorrhage || Infarction, Middle Cerebral Artery || Cerebrovascular Disorders |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0.03452 | INHERITED FROM: Nervous System Malformations || Malformations of Cortical Development |
55681,52954
55681 - Class II aaRS and biotin synthetases
52954 - Class II aaRS ABD-related | 0.04241 | INHERITED FROM: Neuromuscular Diseases |
56784,81665
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.05495 | INHERITED FROM: Paralysis || Ataxia |
90257,90257
90257 - Myosin rod fragments
90257 - Myosin rod fragments | 0.06239 | INHERITED FROM: Muscular Diseases |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 0.09556 | INHERITED FROM: Neurodegenerative Diseases |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.1087 | INHERITED FROM: Cerebral Arterial Diseases || Pain || Intracranial Embolism and Thrombosis || Stroke || Intracranial Thrombosis || Cerebral Infarction || Infarction, Middle Cerebral Artery |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0.1127 | INHERITED FROM: Neuromuscular Diseases |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0.1127 | INHERITED FROM: Neuromuscular Diseases |
81660,56784
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like | 0.1141 | INHERITED FROM: Paralysis || Ataxia |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.1258 | INHERITED FROM: Muscular Disorders, Atrophic || Muscular Dystrophies |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.1799 | INHERITED FROM: Sciatic Neuropathy || Mononeuropathies |
141072,141072
141072 - CalX-like
141072 - CalX-like | 0.1991 | INHERITED FROM: Seizures |
48371,48371
48371 - ARM repeat
48371 - ARM repeat | 0.2446 | INHERITED FROM: Malformations of Cortical Development, Group I |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0.2718 | INHERITED FROM: Multiple Sclerosis || Autoimmune Diseases of the Nervous System || Demyelinating Diseases || Leukoencephalopathies |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0.2876 | INHERITED FROM: Spinocerebellar Ataxias || Movement Disorders || Spinocerebellar Ataxia 17 |
50156,50156
50156 - PDZ domain-like
50156 - PDZ domain-like | 0.3655 | INHERITED FROM: Deafness || Deaf-Blind Disorders || Vision Disorders || Blindness || Usher Syndromes |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.4995 | INHERITED FROM: Muscular Disorders, Atrophic || Muscular Dystrophies || Frontotemporal Lobar Degeneration |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.5188 | INHERITED FROM: Lewy Body Disease |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0.5247 | INHERITED FROM: Cerebral Hemorrhage |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
52799,49562
52799 - (Phosphotyrosine protein) phosphatases II
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
54980,54211
54980 - EF-G C-terminal domain-like
54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
53300,53300
53300 - vWA-like
53300 - vWA-like | 0 | Direct |
47005,52777
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
52777 - CoA-dependent acyltransferases | 0 | Direct |
51230,47005
51230 - Single hybrid motif
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | Direct |
54211,54980
54211 - Ribosomal protein S5 domain 2-like
54980 - EF-G C-terminal domain-like | 0 | Direct |
52518,52922
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 0 | Direct |
48403,52540
48403 - Ankyrin repeat
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.000001754 | Direct |
47454,57959
47454 - A DNA-binding domain in eukaryotic transcription factors
57959 - Leucine zipper domain | 0.01728 | Inherited |
53822,53850
53822 - Periplasmic binding protein-like I
53850 - Periplasmic binding protein-like II | 0.01896 | Inherited |
51905,55424
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.01896 | Inherited |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.02016 | Inherited |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0.03274 | Inherited |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0.03452 | Inherited |
55681,52954
55681 - Class II aaRS and biotin synthetases
52954 - Class II aaRS ABD-related | 0.04241 | Inherited |
56784,81665
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.05495 | Inherited |
90257,90257
90257 - Myosin rod fragments
90257 - Myosin rod fragments | 0.06239 | Inherited |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 0.09556 | Inherited |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.1087 | Inherited |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0.1127 | Inherited |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0.1127 | Inherited |
81660,56784
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like | 0.1141 | Inherited |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.1258 | Inherited |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.1799 | Inherited |
141072,141072
141072 - CalX-like
141072 - CalX-like | 0.1991 | Inherited |
48371,48371
48371 - ARM repeat
48371 - ARM repeat | 0.2446 | Inherited |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0.2718 | Inherited |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0.2876 | Inherited |
50156,50156
50156 - PDZ domain-like
50156 - PDZ domain-like | 0.3655 | Inherited |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.4995 | Inherited |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.5188 | Inherited |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0.5247 | Inherited |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Triple) in N- to C-terminal order( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
54980,54211,54980
54980 - EF-G C-terminal domain-like
54211 - Ribosomal protein S5 domain 2-like
54980 - EF-G C-terminal domain-like | 0 | DIRECT |
64268,50044,50044
64268 - PX domain
50044 - SH3-domain
50044 - SH3-domain | 0 | DIRECT |
51230,47005,52777
51230 - Single hybrid motif
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
52777 - CoA-dependent acyltransferases | 0 | DIRECT |
57440,57440,50494
57440 - Kringle-like
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.05659 | INHERITED FROM: Stroke |
57440,57440,57440
57440 - Kringle-like
57440 - Kringle-like
57440 - Kringle-like | 0.05659 | INHERITED FROM: Peripheral Nervous System Diseases || Diabetic Neuropathies |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0.1127 | INHERITED FROM: Neuromuscular Diseases |
81660,56784,81665
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.1141 | INHERITED FROM: Paralysis || Ataxia |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.1387 | INHERITED FROM: Muscular Disorders, Atrophic || Muscular Dystrophies |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
54980,54211,54980
54980 - EF-G C-terminal domain-like
54211 - Ribosomal protein S5 domain 2-like
54980 - EF-G C-terminal domain-like | 0 | Direct |
64268,50044,50044
64268 - PX domain
50044 - SH3-domain
50044 - SH3-domain | 0 | Direct |
51230,47005,52777
51230 - Single hybrid motif
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
52777 - CoA-dependent acyltransferases | 0 | Direct |
57440,57440,50494
57440 - Kringle-like
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.05659 | Inherited |
57440,57440,57440
57440 - Kringle-like
57440 - Kringle-like
57440 - Kringle-like | 0.05659 | Inherited |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0.1127 | Inherited |
81660,56784,81665
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.1141 | Inherited |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.1387 | Inherited |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Plot distribution on species Tree Of Life (sTOL) for Superfamily and/or Family domains annotated by this CD term
 |
Plot tree as:
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Download Newick format tree:
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( show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Plot distribution on species Tree Of Life (sTOL) for single supra-domains annotated by this CD term
|
Plot tree as:
| |
Download Newick format tree:
| |
Browsing in TREE OF LIFE:
|
( show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
|
|
> BO Hierarchy > Nervous System Diseases
