Zebrafish Anatomy (ZA): compound organ 

Root: ZA Hierarchy (zebrafish anatomy from ZFIN zebrafish anatomy ontology)

Shortest distance to current term (+ for parents, - for children)	ZA term [ZA ID] <#Children>	#Domains (Superfamily|Family)	#Supra-domain (Single|Duplex|Triple)
+ + 2:	zebrafish anatomical entity [ZFA:0100000] <6>
+ 1:	anatomical structure [ZFA:0000037] <16>	(275|296)	(275|157|73)
+ 1:	whole organism [ZFA:0001094] <8>	(272|295)	(272|155|71)
0:	compound organ [ZFA:0000496] <12>	(96|110)	(100|69|30)
- 1:	cavitated compound organ [ZFA:0001490] <15>	(78|91)	(80|55|22)
- 1:	gill [ZFA:0000354] <7>	(1|2)	(2|0|0)
- 1:	skeletal element [ZFA:0005494] <6>	(6|6)	(8|2|3)
- 1:	hypophysis [ZFA:0000118] <3>	(2|3)	(2|0|0)
- 1:	pancreas [ZFA:0000140] <3>	(1|1)	(2|0|0)
- 1:	solid compound organ [ZFA:0001491] <2>	(0|3)	(0|0|0)
- 1:	thymus [ZFA:0001078] <2>	(1|1)	(1|0|0)
- 1:	head kidney [ZFA:0000669] <1>	(0|0)	(0|1|0)
- 1:	gall bladder [ZFA:0000208]	(0|0)	(0|0|0)
- 1:	parapineal organ [ZFA:0001360]	(0|0)	(0|0|0)
- 1:	posterior kidney [ZFA:0001293]	(0|0)	(0|0|0)
- 1:	spleen [ZFA:0000436]	(0|0)	(0|0|0)

Superfamily

Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	DIRECT
Aquaporin-like	0	DIRECT
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	DIRECT
F-box domain	0	DIRECT
HIT-like	0	DIRECT
ALDH-like	0	DIRECT
Moesin tail domain	0	DIRECT
ADC-like	0	DIRECT
Cap-Gly domain	0	DIRECT
Tubulin nucleotide-binding domain-like	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
Translation proteins	0	DIRECT
Caspase-like	0	DIRECT
PLC-like phosphodiesterases	0	DIRECT
Class II aaRS ABD-related	0	DIRECT
Class II aaRS and biotin synthetases	0	DIRECT
Ferredoxin reductase-like, C-terminal NADP-linked domain	0	DIRECT
BRCT domain	0	DIRECT
Quinoprotein alcohol dehydrogenase-like	0	DIRECT
Bet v1-like	0	DIRECT
PP2C-like	0	DIRECT
GroES-like	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
Ypt/Rab-GAP domain of gyp1p	0	DIRECT
Translational machinery components	0	DIRECT
RCC1/BLIP-II	0	DIRECT
CCHHC domain	0	DIRECT
Single hybrid motif	0	DIRECT
Nuclear receptor coactivator interlocking domain	0	DIRECT
SRF-like	0	DIRECT
LCCL domain	0	DIRECT
Lipovitellin-phosvitin complex, superhelical domain	0	DIRECT
CCCH zinc finger	0	DIRECT
BRK domain-like	0	DIRECT
Cupredoxins	0	DIRECT
Sec7 domain	0	DIRECT
JAB1/MPN domain	0	DIRECT
G protein-binding domain	0	DIRECT
Orange domain-like	0	DIRECT
Tricorn protease domain 2	0	DIRECT
BPTI-like	0	DIRECT
Nucleotidylyl transferase	0	DIRECT
DPP6 N-terminal domain-like	0	DIRECT
Cullin repeat-like	0	DIRECT
Polo-box domain	0	DIRECT
Arginase/deacetylase	0	DIRECT
Metallo-dependent hydrolases	0	DIRECT
Glutathione synthetase ATP-binding domain-like	0	DIRECT
Tubulin C-terminal domain-like	0	DIRECT
CalX-like	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
Composite domain of metallo-dependent hydrolases	0	DIRECT
Doublecortin (DC)	0	DIRECT
alpha/beta-Hydrolases	0	DIRECT
Hormone receptor domain	0	DIRECT
Nucleotide cyclase	0	DIRECT
Formin homology 2 domain (FH2 domain)	0	DIRECT
Ras GEF	0	DIRECT
Notch domain	0	DIRECT
SNARE fusion complex	0	DIRECT
Riboflavin synthase domain-like	0	DIRECT
Lipovitellin-phosvitin complex; beta-sheet shell regions	0	DIRECT
Nuclear receptor ligand-binding domain	0.03053	INHERITED FROM: gonad || ovarian follicle stage IV || hypophysis
Homeodomain-like	0.04773	INHERITED FROM: endocrine pancreas || diencephalon || preoptic area || forebrain
FnI-like domain	0.0498	INHERITED FROM: skeletal element || chondral bone || palatoquadrate cartilage || replacement bone
Glucocorticoid receptor-like (DNA-binding domain)	0.06075	INHERITED FROM: VeLD || cardiac ventricle || Kolmer-Agduhr neuron
SMAD/FHA domain	0.08813	INHERITED FROM: vein
Growth factor receptor domain	0.0989	INHERITED FROM: blood vasculature || intramembranous bone
SH2 domain	0.1238	INHERITED FROM: thymus
WD40 repeat-like	0.1289	INHERITED FROM: photoreceptor outer segment layer || retinal outer nuclear layer
Immunoglobulin	0.1289	INHERITED FROM: olfactory bulb glomerulus
Fibronectin type III	0.1526	INHERITED FROM: glomerular layer || synencephalon
Cystine-knot cytokines	0.1964	INHERITED FROM: spermatogenic cyst
EGF/Laminin	0.3023	INHERITED FROM: blood vasculature
Mitochondrial carrier	0.3107	INHERITED FROM: intestine
beta-beta-alpha zinc fingers	0.3357	INHERITED FROM: ventral thalamus
Cyclin-like	0.4078	INHERITED FROM: cranial nerve II
ACT-like	0.4398	INHERITED FROM: ventral wall of dorsal aorta || dorsal aorta || artery
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0.4398	INHERITED FROM: ventral wall of dorsal aorta || dorsal aorta || artery
Alkaline phosphatase-like	0.4398	INHERITED FROM: ceratohyal cartilage
NAD(P)-binding Rossmann-fold domains	0.5035	INHERITED FROM: retinal outer plexiform layer || retinal inner plexiform layer
Cytochrome P450	0.5139	INHERITED FROM: hypophysis
Serine protease inhibitors	0.5203	INHERITED FROM: otolith || otolith organ
Cytokine	0.5203	INHERITED FROM: intramembranous bone
Tropomyosin	0.5203	INHERITED FROM: sinus venosus
DEATH domain	0.5658	INHERITED FROM: blood vasculature
Subtilisin-like	0.6545	INHERITED FROM: optic tectum
Multidrug efflux transporter AcrB transmembrane domain	0.6545	INHERITED FROM: retinal ganglion cell layer || hyosymplectic cartilage
PDZ domain-like	0.6585	INHERITED FROM: central canal
Cadherin-like	0.6987	INHERITED FROM: cranial nerve II || optic tectum || diencephalic white matter
lambda repressor-like DNA-binding domains	0.7297	INHERITED FROM: diencephalon
Retrovirus zinc finger-like domains	0.7972	INHERITED FROM: gill || pharyngeal arch 3-7
Protease propeptides/inhibitors	0.8945	INHERITED FROM: optic tectum
Carbonic anhydrase	0.8945	INHERITED FROM: swim bladder
HLH, helix-loop-helix DNA-binding domain	0.9497	INHERITED FROM: Kolmer-Agduhr neuron
Cysteine proteinases	0.9955	INHERITED FROM: chondrocranium cartilage || skeletal element || cartilage element || ethmoid cartilage || pharyngeal arch cartilage

Family

Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
SRF-like	0	DIRECT
Elongation factors	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
Platelet-derived growth factor-like	0	DIRECT
Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	0	DIRECT
Actin/HSP70	0	DIRECT
Mammalian PLC	0	DIRECT
F-box domain	0	DIRECT
Formin homology 2 domain (FH2 domain)	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
Ephrin receptor ligand binding domain	0	DIRECT
Hydantoinase (dihydropyrimidinase)	0	DIRECT
Sec7 domain	0	DIRECT
SNARE fusion complex	0	DIRECT
L domain	0	DIRECT
Aquaporin-like	0	DIRECT
Biotinyl/lipoyl-carrier proteins and domains	0	DIRECT
CalX-beta domain	0	DIRECT
Histone lysine methyltransferases	0	DIRECT
P4 origin-binding domain-like	0	DIRECT
Ephrin ectodomain	0	DIRECT
Cytoplasmic domain of inward rectifier potassium channel	0	DIRECT
V set domains (antibody variable domain-like)	0	DIRECT
Adenylyl and guanylyl cyclase catalytic domain	0	DIRECT
Small Kunitz-type inhibitors & BPTI-like toxins	0	DIRECT
Lipovitellin-phosvitin complex; beta-sheet shell regions	0	DIRECT
Cap-Gly domain	0	DIRECT
C5 cytosine-specific DNA methylase, DCM	0	DIRECT
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta	0	DIRECT
Histone deacetylase, HDAC	0	DIRECT
Tubulin, GTPase domain	0	DIRECT
Noncollagenous (NC1) domain of collagen IV	0	DIRECT
Pyridoxal-dependent decarboxylase	0	DIRECT
CCCH zinc finger	0	DIRECT
Hairy Orange domain	0	DIRECT
Tubulin, C-terminal domain	0	DIRECT
CCHHC domain	0	DIRECT
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain	0	DIRECT
Phoshoinositide 3-kinase (PI3K), catalytic domain	0	DIRECT
LCCL domain	0	DIRECT
Connexin43	0	DIRECT
Phoshoinositide 3-kinase (PI3K) helical domain	0	DIRECT
Anticodon-binding domain of Class II aaRS	0	DIRECT
Regulator of chromosome condensation RCC1	0	DIRECT
Reprolysin-like	0	DIRECT
Doublecortin (DC)	0	DIRECT
Extracellular domain of cell surface receptors	0	DIRECT
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	DIRECT
Hormone receptor domain	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
Nuclear receptor coactivator interlocking domain	0	DIRECT
Chromo domain	0	DIRECT
Hydantoinase (dihydropyrimidinase), catalytic domain	0	DIRECT
Glycerophosphoryl diester phosphodiesterase	0	DIRECT
Moesin tail domain	0	DIRECT
Erythroid transcription factor GATA-1	0	DIRECT
VWC domain	0	DIRECT
Tetramerization domain of potassium channels	0	DIRECT
Long-chain cytokines	0	DIRECT
Caspase catalytic domain	0	DIRECT
Cell cycle transcription factor e2f-dp	0	DIRECT
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain	0	DIRECT
ALDH-like	0	DIRECT
PP2C-like	0	DIRECT
Notch domain	0	DIRECT
Ras GEF	0	DIRECT
Pentraxin (pentaxin)	0	DIRECT
Cdc48 N-terminal domain-like	0	DIRECT
FHA domain	0	DIRECT
Rel/Dorsal transcription factors, DNA-binding domain	0	DIRECT
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	DIRECT
Class I aminoacyl-tRNA synthetases (RS), catalytic domain	0	DIRECT
Ovomucoid domain III-like	0	DIRECT
Single strand DNA-binding domain, SSB	0	DIRECT
Lipovitellin-phosvitin complex, superhelical domain	0	DIRECT
BRK domain-like	0	DIRECT
SWIRM domain	0	DIRECT
Protein kinases, catalytic subunit	0.0028	INHERITED FROM: dorsal longitudinal anastomotic vessel
Nuclear receptor ligand-binding domain	0.02302	INHERITED FROM: gonad || ovarian follicle stage IV || hypophysis
Nuclear receptor	0.02773	INHERITED FROM: gonad || ovarian follicle stage IV || hypophysis
Homeodomain	0.03337	INHERITED FROM: endocrine pancreas || diencephalon || preoptic area || dorsal telencephalon || forebrain
WD40-repeat	0.07015	INHERITED FROM: photoreceptor outer segment layer || retinal cone cell
SH2 domain	0.1032	INHERITED FROM: thymus
Motor proteins	0.1206	INHERITED FROM: renal corpuscle || photoreceptor outer segment layer || pronephric podocyte
Fibronectin type III	0.1278	INHERITED FROM: glomerular layer || synencephalon
Tetratricopeptide repeat (TPR)	0.1818	INHERITED FROM: retinal rod cell
HMG-box	0.1818	INHERITED FROM: ceratobranchial 5 bone
Zf-UBP	0.231	INHERITED FROM: chondrocranium cartilage || Meckel's cartilage || ethmoid cartilage
Transforming growth factor (TGF)-beta	0.2527	INHERITED FROM: spermatogenic cyst || pineal complex
I set domains	0.2674	INHERITED FROM: synencephalon
POU-specific domain	0.2791	INHERITED FROM: diencephalon || forebrain
Phenylalanine metabolism regulatory domain	0.4071	INHERITED FROM: ventral wall of dorsal aorta || dorsal aorta || artery
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0.4071	INHERITED FROM: ventral wall of dorsal aorta || dorsal aorta || artery
Multidrug efflux transporter AcrB transmembrane domain	0.4071	INHERITED FROM: retinal ganglion cell layer || hyosymplectic cartilage
Group II chaperonin (CCT, TRIC), intermediate domain	0.4071	INHERITED FROM: solid compound organ || liver
PDZ domain	0.4155	INHERITED FROM: central canal
Classic zinc finger, C2H2	0.4326	INHERITED FROM: ventral thalamus || thalamus
Cytochrome P450	0.4818	INHERITED FROM: hypophysis
Fibroblast growth factors (FGF)	0.4893	INHERITED FROM: intramembranous bone
Tropomyosin	0.4893	INHERITED FROM: sinus venosus
T-box	0.5322	INHERITED FROM: pronephros || atrioventricular canal
LIM domain	0.5618	INHERITED FROM: cardiac ventricle
Group II chaperonin (CCT, TRIC), apical domain	0.6242	INHERITED FROM: solid compound organ
Calcium ATPase, transmembrane domain M	0.6242	INHERITED FROM: atrium
Group II chaperonin (CCT, TRIC), ATPase domain	0.7027	INHERITED FROM: solid compound organ || liver
Cadherin	0.7168	INHERITED FROM: cranial nerve II || optic tectum || diencephalic white matter
Retrovirus zinc finger-like domains	0.7815	INHERITED FROM: gill || pharyngeal arch 3-7
Ubiquitin carboxyl-terminal hydrolase, UCH	0.7947	INHERITED FROM: skeletal element || cartilage element || cranial cartilage || ethmoid cartilage || pharyngeal arch cartilage
Carbonic anhydrase	0.8865	INHERITED FROM: swim bladder
HLH, helix-loop-helix DNA-binding domain	0.944	INHERITED FROM: Kolmer-Agduhr neuron

Supra-domain (Single|Duplex|Triple)

Supra-domain (Single)

Highlighted in gray are those with FDR>0.001

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Ras GEF	0	DIRECT
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	DIRECT
Tricorn protease domain 2	0	DIRECT
Class II aaRS ABD-related	0	DIRECT
Nuclear receptor coactivator interlocking domain	0	DIRECT
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	DIRECT
Cap-Gly domain	0	DIRECT
G protein-binding domain	0	DIRECT
Aquaporin-like	0	DIRECT
Ferredoxin reductase-like, C-terminal NADP-linked domain	0	DIRECT
Riboflavin synthase domain-like	0	DIRECT
Orange domain-like	0	DIRECT
BRCT domain	0	DIRECT
Quinoprotein alcohol dehydrogenase-like	0	DIRECT
Class II aaRS and biotin synthetases	0	DIRECT
PLC-like phosphodiesterases	0	DIRECT
GroES-like	0	DIRECT
Ypt/Rab-GAP domain of gyp1p	0	DIRECT
SNARE fusion complex	0	DIRECT
BPTI-like	0	DIRECT
Cullin repeat-like	0	DIRECT
JAB1/MPN domain	0	DIRECT
Nucleotide cyclase	0	DIRECT
Translational machinery components	0	DIRECT
Glutathione synthetase ATP-binding domain-like	0	DIRECT
Metallo-dependent hydrolases	0	DIRECT
Nucleotidylyl transferase	0	DIRECT
DPP6 N-terminal domain-like	0	DIRECT
PP2C-like	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
Polo-box domain	0	DIRECT
Single hybrid motif	0	DIRECT
F-box domain	0	DIRECT
ALDH-like	0	DIRECT
HIT-like	0	DIRECT
Arginase/deacetylase	0	DIRECT
SRF-like	0	DIRECT
alpha/beta-Hydrolases	0	DIRECT
Moesin tail domain	0	DIRECT
Composite domain of metallo-dependent hydrolases	0	DIRECT
BRK domain-like	0	DIRECT
CalX-like	0	DIRECT
Lipovitellin-phosvitin complex; beta-sheet shell regions	0	DIRECT
Translation proteins	0	DIRECT
Tubulin C-terminal domain-like	0	DIRECT
Caspase-like	0	DIRECT
ADC-like	0	DIRECT
Sec7 domain	0	DIRECT
Hormone receptor domain	0	DIRECT
Bet v1-like	0	DIRECT
Doublecortin (DC)	0	DIRECT
Notch domain	0	DIRECT
RCC1/BLIP-II	0	DIRECT
Lipovitellin-phosvitin complex, superhelical domain	0	DIRECT
Tubulin nucleotide-binding domain-like	0	DIRECT
Formin homology 2 domain (FH2 domain)	0	DIRECT
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
CCHHC domain	0	DIRECT
CCCH zinc finger	0	DIRECT
Cupredoxins	0	DIRECT
LCCL domain	0	DIRECT
Protein kinase-like (PK-like)	0.0006993	DIRECT
Nuclear receptor ligand-binding domain	0.02227	INHERITED FROM: ovarian follicle stage IV || gonad || hypophysis
Homeodomain-like	0.0355	INHERITED FROM: preoptic area || endocrine pancreas || diencephalon || dorsal telencephalon || forebrain
FnI-like domain	0.03713	INHERITED FROM: palatoquadrate cartilage || chondral bone || replacement bone || skeletal element
Glucocorticoid receptor-like (DNA-binding domain)	0.04622	INHERITED FROM: ovarian follicle stage IV || Kolmer-Agduhr neuron || cardiac ventricle || VeLD
SMAD/FHA domain	0.06938	INHERITED FROM: vein
Growth factor receptor domain	0.0787	INHERITED FROM: blood vasculature || intramembranous bone
SH2 domain	0.1009	INHERITED FROM: thymus
WD40 repeat-like	0.1054	INHERITED FROM: eye || retinal photoreceptor layer || retinal outer nuclear layer || photoreceptor outer segment layer
Immunoglobulin	0.1054	INHERITED FROM: synencephalon || olfactory bulb glomerulus || glomerular layer
Fibronectin type III	0.1271	INHERITED FROM: synencephalon || glomerular layer
Cystine-knot cytokines	0.1675	INHERITED FROM: pineal complex || spermatogenic cyst || cranial blood vessel
HMG-box	0.1803	INHERITED FROM: ceratobranchial 5 bone
EGF/Laminin	0.2699	INHERITED FROM: blood vasculature
Mitochondrial carrier	0.278	INHERITED FROM: intestine
beta-beta-alpha zinc fingers	0.3021	INHERITED FROM: ventral thalamus
Cyclin-like	0.3732	INHERITED FROM: cranial nerve II
ACT-like	0.4052	INHERITED FROM: artery || ventral wall of dorsal aorta || dorsal aorta
Alkaline phosphatase-like	0.4052	INHERITED FROM: ceratohyal cartilage
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0.4052	INHERITED FROM: artery || ventral wall of dorsal aorta || dorsal aorta
NAD(P)-binding Rossmann-fold domains	0.4708	INHERITED FROM: retinal inner plexiform layer || retinal outer plexiform layer
Cytochrome P450	0.4813	INHERITED FROM: hypophysis
Serine protease inhibitors	0.4883	INHERITED FROM: otolith organ || otolith
Tropomyosin	0.4883	INHERITED FROM: sinus venosus
Cytokine	0.4883	INHERITED FROM: skeletal element || intramembranous bone
DEATH domain	0.5351	INHERITED FROM: blood vasculature
Multidrug efflux transporter AcrB transmembrane domain	0.6271	INHERITED FROM: hyosymplectic cartilage || retinal ganglion cell layer
Subtilisin-like	0.6271	INHERITED FROM: optic tectum
PDZ domain-like	0.6309	INHERITED FROM: central canal
Cadherin-like	0.673	INHERITED FROM: optic tectum || cranial nerve II || diencephalic white matter
lambda repressor-like DNA-binding domains	0.706	INHERITED FROM: diencephalon
Neurotransmitter-gated ion-channel transmembrane pore	0.706	INHERITED FROM: spinal cord
Retrovirus zinc finger-like domains	0.7801	INHERITED FROM: gill || pharyngeal arch 3-7
UBA-like	0.8574	INHERITED FROM: ethmoid cartilage
Protease propeptides/inhibitors	0.8843	INHERITED FROM: optic tectum
Carbonic anhydrase	0.8843	INHERITED FROM: swim bladder
HLH, helix-loop-helix DNA-binding domain	0.9462	INHERITED FROM: Kolmer-Agduhr neuron
Cysteine proteinases	0.9979	INHERITED FROM: pharyngeal arch cartilage || chondrocranium cartilage || ethmoid cartilage || skeletal element || cartilage element

Supra-domain (Duplex) in N- to C-terminal order

Highlighted in gray are those with FDR>0.001

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
57196,63825 57196 - EGF/Laminin 63825 - YWTD domain	0	DIRECT
49899,57196 49899 - Concanavalin A-like lectins/glucanases 57196 - EGF/Laminin	0	DIRECT
50447,50465 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	DIRECT
47459,158457 47459 - HLH, helix-loop-helix DNA-binding domain 158457 - Orange domain-like	0	DIRECT
54001,143791 54001 - Cysteine proteinases 143791 - DUSP-like	0	DIRECT
48425,50729 48425 - Sec7 domain 50729 - PH domain-like	0	DIRECT
48371,48371 48371 - ARM repeat 48371 - ARM repeat	0	DIRECT
56112,47769 56112 - Protein kinase-like (PK-like) 47769 - SAM/Pointed domain	0	DIRECT
50729,47473 50729 - PH domain-like 47473 - EF-hand	0	DIRECT
48097,56112 48097 - Regulator of G-protein signaling, RGS 56112 - Protein kinase-like (PK-like)	0	DIRECT
63380,52343 63380 - Riboflavin synthase domain-like 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain	0	DIRECT
57362,57362 57362 - BPTI-like 57362 - BPTI-like	0	DIRECT
57184,52058 57184 - Growth factor receptor domain 52058 - L domain-like	0	DIRECT
103575,81296 103575 - Plexin repeat 81296 - E set domains	0	DIRECT
49265,49899 49265 - Fibronectin type III 49899 - Concanavalin A-like lectins/glucanases	0	DIRECT
81324,81296 81324 - Voltage-gated potassium channels 81296 - E set domains	0	DIRECT
111418,81321 111418 - Hormone receptor domain 81321 - Family A G protein-coupled receptor-like	0	DIRECT
57196,49899 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases	0	DIRECT
51556,51338 51556 - Metallo-dependent hydrolases 51338 - Composite domain of metallo-dependent hydrolases	0	DIRECT
48371,56112 48371 - ARM repeat 56112 - Protein kinase-like (PK-like)	0	DIRECT
54160,54160 54160 - Chromo domain-like 54160 - Chromo domain-like	0	DIRECT
54585,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
57603,57603 57603 - FnI-like domain 57603 - FnI-like domain	0	DIRECT
81324,81324 81324 - Voltage-gated potassium channels 81324 - Voltage-gated potassium channels	0	DIRECT
89837,89837 89837 - Doublecortin (DC) 89837 - Doublecortin (DC)	0	DIRECT
46785,46785 46785 - "Winged helix" DNA-binding domain 46785 - "Winged helix" DNA-binding domain	0	DIRECT
90193,90193 90193 - Notch domain 90193 - Notch domain	0	DIRECT
57184,57603 57184 - Growth factor receptor domain 57603 - FnI-like domain	0	DIRECT
50729,56112 50729 - PH domain-like 56112 - Protein kinase-like (PK-like)	0	DIRECT
53067,100920 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
55550,55550 55550 - SH2 domain 55550 - SH2 domain	0	DIRECT
50044,55550 50044 - SH3-domain 55550 - SH2 domain	0	DIRECT
46966,47473 46966 - Spectrin repeat 47473 - EF-hand	0	DIRECT
49417,81296 49417 - p53-like transcription factors 81296 - E set domains	0	DIRECT
54160,52540 54160 - Chromo domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
52058,49265 52058 - L domain-like 49265 - Fibronectin type III	0	DIRECT
56968,48431 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions 48431 - Lipovitellin-phosvitin complex, superhelical domain	0	DIRECT
141072,141072 141072 - CalX-like 141072 - CalX-like	0	DIRECT
57903,57903 57903 - FYVE/PHD zinc finger 57903 - FYVE/PHD zinc finger	0	DIRECT
56112,56112 56112 - Protein kinase-like (PK-like) 56112 - Protein kinase-like (PK-like)	0	DIRECT
57196,90193 57196 - EGF/Laminin 90193 - Notch domain	0	DIRECT
52540,50447 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins	0	DIRECT
52490,55307 52490 - Tubulin nucleotide-binding domain-like 55307 - Tubulin C-terminal domain-like	0	DIRECT
54791,54791 54791 - Eukaryotic type KH-domain (KH-domain type I) 54791 - Eukaryotic type KH-domain (KH-domain type I)	0	DIRECT
52374,47323 52374 - Nucleotidylyl transferase 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0	DIRECT
47986,52129 47986 - DEATH domain 52129 - Caspase-like	0	DIRECT
50692,54585 50692 - ADC-like 54585 - Cdc48 domain 2-like	0	DIRECT
55550,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like)	0	DIRECT
47473,51695 47473 - EF-hand 51695 - PLC-like phosphodiesterases	0	DIRECT
50978,50998 50978 - WD40 repeat-like 50998 - Quinoprotein alcohol dehydrogenase-like	0	DIRECT
49562,48371 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat	0	DIRECT
52799,49562 52799 - (Phosphotyrosine protein) phosphatases II 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)	0	DIRECT
52058,57184 52058 - L domain-like 57184 - Growth factor receptor domain	0	DIRECT
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin	0.06102	INHERITED FROM: synencephalon
57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain)	0.1753	INHERITED FROM: heart || Kolmer-Agduhr neuron || cardiac ventricle || VeLD
57184,57184 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain	0.1879	INHERITED FROM: blood vasculature || blood vessel
90257,90257 90257 - Myosin rod fragments 90257 - Myosin rod fragments	0.278	INHERITED FROM: midbrain hindbrain boundary
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin	0.3204	INHERITED FROM: blood vasculature
48726,49265 48726 - Immunoglobulin 49265 - Fibronectin type III	0.3875	INHERITED FROM: synencephalon || brain nucleus
55021,56534 55021 - ACT-like 56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0.4052	INHERITED FROM: artery || ventral wall of dorsal aorta || dorsal aorta
49265,49265 49265 - Fibronectin type III 49265 - Fibronectin type III	0.4218	INHERITED FROM: head kidney
57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers	0.4808	INHERITED FROM: ventral thalamus || thalamus
49562,48350 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48350 - GTPase activation domain, GAP	0.4883	INHERITED FROM: hindbrain
69179,69179 69179 - Integrin domains 69179 - Integrin domains	0.6271	INHERITED FROM: bone element
69318,69179 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains	0.6271	INHERITED FROM: bone element
48452,48452 48452 - TPR-like 48452 - TPR-like	0.6614	INHERITED FROM: pronephros
54897,52743 54897 - Protease propeptides/inhibitors 52743 - Subtilisin-like	0.7023	INHERITED FROM: optic tectum
50156,50156 50156 - PDZ domain-like 50156 - PDZ domain-like	0.706	INHERITED FROM: eye photoreceptor cell || retinal outer nuclear layer
49313,49313 49313 - Cadherin-like 49313 - Cadherin-like	0.7613	INHERITED FROM: optic tectum || cranial nerve II || retinal ganglion cell layer || diencephalic white matter

Supra-domain (Triple) in N- to C-terminal order

Highlighted in gray are those with FDR>0.001

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
57196,57184,57196 57196 - EGF/Laminin 57184 - Growth factor receptor domain 57196 - EGF/Laminin	0	DIRECT
50692,54585,52540 50692 - ADC-like 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
57184,52058,49265 57184 - Growth factor receptor domain 52058 - L domain-like 49265 - Fibronectin type III	0	DIRECT
103575,81296,81296 103575 - Plexin repeat 81296 - E set domains 81296 - E set domains	0	DIRECT
46966,46966,47473 46966 - Spectrin repeat 46966 - Spectrin repeat 47473 - EF-hand	0	DIRECT
57196,57184,57184 57196 - EGF/Laminin 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain	0	DIRECT
49899,57196,57196 49899 - Concanavalin A-like lectins/glucanases 57196 - EGF/Laminin 57196 - EGF/Laminin	0	DIRECT
57603,57603,57603 57603 - FnI-like domain 57603 - FnI-like domain 57603 - FnI-like domain	0	DIRECT
54585,52540,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
57196,90193,90193 57196 - EGF/Laminin 90193 - Notch domain 90193 - Notch domain	0	DIRECT
57184,52058,57184 57184 - Growth factor receptor domain 52058 - L domain-like 57184 - Growth factor receptor domain	0	DIRECT
52058,57184,52058 52058 - L domain-like 57184 - Growth factor receptor domain 52058 - L domain-like	0	DIRECT
57184,57184,57196 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain 57196 - EGF/Laminin	0	DIRECT
54160,52540,52540 54160 - Chromo domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
57196,57196,90193 57196 - EGF/Laminin 57196 - EGF/Laminin 90193 - Notch domain	0	DIRECT
52540,50447,50465 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain	0	DIRECT
49562,48371,56112 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat 56112 - Protein kinase-like (PK-like)	0	DIRECT
90193,90193,90193 90193 - Notch domain 90193 - Notch domain 90193 - Notch domain	0	DIRECT
90257,90257,90257 90257 - Myosin rod fragments 90257 - Myosin rod fragments 90257 - Myosin rod fragments	0	DIRECT
53067,53067,100920 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
50729,47473,51695 50729 - PH domain-like 47473 - EF-hand 51695 - PLC-like phosphodiesterases	0	DIRECT
54160,54160,52540 54160 - Chromo domain-like 54160 - Chromo domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
52058,49265,49265 52058 - L domain-like 49265 - Fibronectin type III 49265 - Fibronectin type III	0	DIRECT
57196,49899,49899 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases	0	DIRECT
48726,48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin 48726 - Immunoglobulin	0.09047	INHERITED FROM: synencephalon
57716,57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain)	0.4813	INHERITED FROM: cardiac ventricle
48726,48726,49265 48726 - Immunoglobulin 48726 - Immunoglobulin 49265 - Fibronectin type III	0.565	INHERITED FROM: synencephalon || brain nucleus
49313,49313,49313 49313 - Cadherin-like 49313 - Cadherin-like 49313 - Cadherin-like	0.6127	INHERITED FROM: optic tectum || cranial nerve II || retinal ganglion cell layer || diencephalic white matter
69179,69179,69179 69179 - Integrin domains 69179 - Integrin domains 69179 - Integrin domains	0.6271	INHERITED FROM: bone element
69318,69179,69179 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains 69179 - Integrin domains	0.6271	INHERITED FROM: bone element