Phospholipase A2, PLA2 superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All alpha proteins [ 46456] (284)
• Fold: Phospholipase A2, PLA2 [ 48618]
• Superfamily: Phospholipase A2, PLA2 [ 48619] (3)
• Families:
  • Vertebrate phospholipase A2 [ 48623] (2)
  • Insect phospholipase A2 [ 48620]
  • Prokaryotic phospholipase A2 [ 63630]

---

Superfamily statistics

	Genomes (401)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	2,365	8,423	86
Proteins	2,223	8,120	86

---

Functional annotation

• General category: Processes_IC
• Detailed category: Phospholipid metabolism and transport

---

Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Hydrolases	0	0.04271	--	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0	0.4665	Least Informative	DIRECT
Enzyme Commission (EC)	Carboxylic ester hydrolases	0	1.217	Moderately Informative	DIRECT
Enzyme Commission (EC)	Phospholipase A(2)	0	2.083	Highly Informative	DIRECT

---

Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	arteriosclerotic cardiovascular disease	0.0003912	1.257	--	DIRECT
Disease Ontology (DO)	arteriosclerosis	0.0004366	1.257	--	DIRECT
Disease Ontology (DO)	vascular disease	0.01354	0.8029	--	INHERITED FROM: arteriosclerotic cardiovascular disease || arteriosclerosis || atherosclerosis
Disease Ontology (DO)	cardiovascular system disease	0.04026	0.7583	--	INHERITED FROM: atherosclerosis || arteriosclerotic cardiovascular disease || arteriosclerosis
Disease Ontology (DO)	disease of anatomical entity	0.1453	0.2157	--	INHERITED FROM: atherosclerosis || arteriosclerosis || arteriosclerotic cardiovascular disease
Disease Ontology (DO)	artery disease	0.008727	0.9087	Moderately Informative	INHERITED FROM: atherosclerosis || arteriosclerosis || arteriosclerotic cardiovascular disease
Disease Ontology (DO)	atherosclerosis	0.0003867	1.257	Informative	DIRECT

---

Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.07108	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.01121	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.08329	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001706	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.004279	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.05921	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.07209	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.171	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1685	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.06709	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.1278	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1672	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.09267	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || reproductive system physiology variant || lethal || development variant || hermaphrodite sterile || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || fertility variant || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.161	--	INHERITED FROM: hermaphrodite sterile || maternal sterile

---

Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	viable	0	0.735	Least Informative	DIRECT
Fly Phenotype (FP)	fertile	0	0.981	Moderately Informative	DIRECT

---

Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1442	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1871	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.24	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.193	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1217	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.09747	--	INHERITED FROM: anatomical group || multicellular anatomical structure || compound organ || anatomical region || organism subdivision
Xenopus DEvelopment stage (XDE)	post-embryonic stage	0	0.5693	Least Informative	DIRECT

---

Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	phyllome	0	0.3809	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05747	--	DIRECT
Plant ANatomical entity (PAN)	plant organ	0	0.2816	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2691	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01577	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || phyllome || multi-tissue plant structure || shoot system || plant organ || whole plant
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.04502	--	INHERITED FROM: phyllome || shoot system
Plant ANatomical entity (PAN)	whole plant	0	0.4218	Least Informative	DIRECT

---

Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Acting on ester bonds	0	0.7559	--	DIRECT
Enzyme Commission (EC)	Phospholipase A(2)	0	2.253	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.3541	Least Informative	DIRECT
Enzyme Commission (EC)	Carboxylic ester hydrolases	0	1.408	Informative	DIRECT

---