|
|
Acting on ester bonds
(show info)
Enzyme Commission (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed. To navigate hierarchical structure of EC, we display all parental EC terms to the current EC term of interest ordered by their shortest distances to the current term. Also, only direct children EC terms of the current EC term are listed.
Structural Classification of Proteins (SCOP)
SCOP classifies evolutionary-related domains into Superfamily level and Family level. Accordingly, we have generated the domain-centric EC annotations for each of the three concepts at each of the two domain levels.
Structural Domain Enzyme Commission Ontology (SDEO)
As domain-centric ontology, SDEO only refers to those EC terms which are the most informative to annotate SCOP domains.
EC annotations for SCOP domains
For details, please visit Documentation: EC annotations for SCOP domains. Therein, we provide several relevant files ( Data Availability) for the download, including an annotation file (i.e., Domain2EC.txt) and the corresponding ontology (i.e., SDEO.txt).
Supra-domain Enzyme Commission Ontology (SPEO)
As an extension, SPEO includes those EC terms which are the most informative to annotate supra-domains and individual SCOP domains at the Superfamily level.
EC annotations for Supra-domains
For details, please visit Documentation: EC annotations for Supra-domains. Therein, we provide several relevant files ( Data Availability) for the download, including a annotation file (i.e., SP2EC.txt) and an ontology (i.e., SPEO.txt). For the sake of being browsable, listed below are those supra-domains (single, dual, triple, quad).
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Root: EC Hierarchy (from IntEnz release 70)
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this EC term (SDEO level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| cAMP-binding domain-like | 0 | DIRECT |
| PH domain-like | 0 | DIRECT |
| tRNA-intron endonuclease N-terminal domain-like | 0 | DIRECT |
| Carbohydrate phosphatase | 0 | DIRECT |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0 | DIRECT |
| EF-hand | 0 | DIRECT |
| FabD/lysophospholipase-like | 0 | DIRECT |
| Purple acid phosphatase, N-terminal domain | 0 | DIRECT |
| Somatomedin B domain | 0 | DIRECT |
| AlbA-like | 0 | DIRECT |
| DNA/RNA polymerases | 0 | DIRECT |
| DNA-binding domain of retroviral integrase | 0 | DIRECT |
| Retrovirus capsid dimerization domain-like | 0 | DIRECT |
| Methylesterase CheB, C-terminal domain | 0 | DIRECT |
| Toprim domain | 0 | DIRECT |
| Phospholipase C/P1 nuclease | 0 | DIRECT |
| C-terminal domain of PLC-beta | 0 | DIRECT |
| XseB-like | 0 | DIRECT |
| CheY-like | 0 | DIRECT |
| GAF domain-like | 0 | DIRECT |
| Outer membrane phospholipase A (OMPLA) | 0 | DIRECT |
| (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
| tRNA-intron endonuclease catalytic domain-like | 0 | DIRECT |
| RNase A-like | 0 | DIRECT |
| Ribonuclease H-like | 0 | DIRECT |
| Plant invertase/pectin methylesterase inhibitor | 0 | DIRECT |
| Rof/RNase P subunit-like | 0 | DIRECT |
| Putative isomerase YbhE | 0 | DIRECT |
| Holliday junction resolvase RusA | 0 | DIRECT |
| Phosphoglycerate mutase-like | 0 | DIRECT |
| Rnp2-like | 0 | DIRECT |
| DNase I-like | 0 | DIRECT |
| Phospholipase A2, PLA2 | 0 | DIRECT |
| Ribosomal protein S5 domain 2-like | 0 | DIRECT |
| HAD-like | 0 | DIRECT |
| Phosphotyrosine protein phosphatases I | 0 | DIRECT |
| RNase III domain-like | 0 | DIRECT |
| Nitrous oxide reductase, N-terminal domain | 0 | DIRECT |
| His-Me finger endonucleases | 0 | DIRECT |
| Retroviral matrix proteins | 0 | DIRECT |
| Metallo-dependent phosphatases | 0 | DIRECT |
| SGNH hydrolase | 0 | DIRECT |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
| HD-domain/PDEase-like | 0 | DIRECT |
| Peptidyl-tRNA hydrolase domain-like | 0 | DIRECT |
| alpha/beta-Hydrolases | 0 | DIRECT |
| Peptidyl-tRNA hydrolase-like | 0 | DIRECT |
| Ribonuclease Rh-like | 0 | DIRECT |
| Retrovirus capsid protein, N-terminal core domain | 0 | DIRECT |
| Peptidyl-tRNA hydrolase II | 0 | DIRECT |
| L9 N-domain-like | 0 | DIRECT |
| Viral protein domain | 0 | DIRECT |
| SurE-like | 0 | DIRECT |
| Rhodanese/Cell cycle control phosphatase | 0 | DIRECT |
| ComB-like | 0 | DIRECT |
| Protein serine/threonine phosphatase 2C, C-terminal domain | 0 | DIRECT |
| Xylose isomerase-like | 0 | DIRECT |
| Metallo-hydrolase/oxidoreductase | 0 | DIRECT |
| PP2C-like | 0 | DIRECT |
| Acid phosphatase/Vanadium-dependent haloperoxidase | 0 | DIRECT |
| Microbial ribonucleases | 0 | DIRECT |
| Influenza hemagglutinin (stalk) | 0 | DIRECT |
| PLC-like phosphodiesterases | 0 | DIRECT |
| Retrovirus zinc finger-like domains | 0 | DIRECT |
| N-terminal Zn binding domain of HIV integrase | 0 | DIRECT |
| Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
| dsRNA-binding domain-like | 0 | DIRECT |
| Thermostable phytase (3-phytase) | 0 | DIRECT |
| Calcium-dependent phosphotriesterase | 0 | DIRECT |
| Phospholipase D/nuclease | 0 | DIRECT |
| WD40 repeat-like | 2.368e-16 | DIRECT |
| Fibronectin type III | 0.000000000000007826 | DIRECT |
| PHP domain-like | 0.0000000000003611 | DIRECT |
| Staphylococcal nuclease | 0.0000000001806 | DIRECT |
| 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain | 0.0000000004081 | DIRECT |
| DEK C-terminal domain | 0.000000002607 | DIRECT |
| EAL domain-like | 0.00000000504 | DIRECT |
| LigT-like | 0.000000006659 | DIRECT |
| Alkaline phosphatase-like | 0.000000006922 | DIRECT |
| Second domain of FERM | 0.00000002725 | DIRECT |
| PX domain | 0.0000005668 | DIRECT |
| Integrin alpha N-terminal domain | 0.000001942 | DIRECT |
| Saposin | 0.000003905 | DIRECT |
| SH2 domain | 0.000006817 | DIRECT |
| L domain-like | 0.00000756 | DIRECT |
| Acid proteases | 0.000008641 | DIRECT |
| CYTH-like phosphatases | 0.0001559 | DIRECT |
| Immunoglobulin | 0.0001702 | DIRECT |
| Pectin lyase-like | 0.0003098 | DIRECT |
| NTF2-like | 0.0006578 | DIRECT |
| HRDC-like | 0.001517 | INHERITED FROM: Ribonuclease D || Exoribonucleases producing 5'-phosphomonoesters |
| RNA-binding domain, RBD | 0.003436 | INHERITED FROM: Phosphoinositide 5-phosphatase || Poly(A)-specific ribonuclease || Exoribonucleases producing 5'-phosphomonoesters |
| Kelch motif | 0.007019 | INHERITED FROM: Phosphoric monoester hydrolases || Phosphoprotein phosphatase |
| Ubiquitin-like | 0.0102 | INHERITED FROM: Protein-tyrosine-phosphatase || Phosphoric monoester hydrolases |
| R3H domain | 0.03192 | INHERITED FROM: Poly(A)-specific ribonuclease || Exoribonucleases producing 5'-phosphomonoesters |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.07992 | INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase || Thiolester hydrolases |
| Ankyrin repeat | 0.1213 | INHERITED FROM: Carboxylic ester hydrolases |
| DNA clamp | 0.1514 | INHERITED FROM: Exodeoxyribonucleases producing 5'-phosphomonoeste || Exodeoxyribonuclease III |
| FYVE/PHD zinc finger | 0.2911 | INHERITED FROM: Protein-tyrosine-phosphatase || Phosphoric monoester hydrolases |
| SH3-domain | 0.4052 | INHERITED FROM: Phosphoric diester hydrolases || Phosphoinositide phospholipase C |
| Carbonic anhydrase | 0.4594 | INHERITED FROM: Protein-tyrosine-phosphatase |
| PYP-like sensor domain (PAS domain) | 0.4681 | INHERITED FROM: 3',5'-cyclic-nucleotide phosphodiesterase || Phosphoric diester hydrolases |
| TPR-like | 0.5472 | INHERITED FROM: Phosphoprotein phosphatase |
| SAM/Pointed domain | 0.558 | INHERITED FROM: Phosphatidylinositol-3,4,5-trisphosphate 5-phospha |
| ACP-like | 0.6299 | INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase || Thiolester hydrolases |
| AraD/HMP-PK domain-like | 0.997 | INHERITED FROM: Acireductone synthase |
| Restriction endonuclease-like | 1 | INHERITED FROM: Endodeoxyribonucleases producing 5'-phosphomonoest || Exodeoxyribonucleases producing 5'-phosphomonoeste || Type II site-specific deoxyribonuclease || Exodeoxyribonuclease V |
| P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: Fructose-2,6-bisphosphate 2-phosphatase || Type I site-specific deoxyribonuclease || Exodeoxyribonuclease V || Polynucleotide 5'-phosphatase |
| Macro domain-like | 1 | INHERITED FROM: Phosphoric monoester hydrolases || ADP-ribose 1''-phosphate phosphatase || Polynucleotide 5'-phosphatase |
| S-adenosyl-L-methionine-dependent methyltransferases | 1 | INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase || Polynucleotide 5'-phosphatase |
| ClpP/crotonase | 1 | INHERITED FROM: Thiolester hydrolases || 3-hydroxyisobutyryl-CoA hydrolase |
| GroES-like | 1 | INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase |
| NagB/RpiA/CoA transferase-like | 1 | INHERITED FROM: Acetyl-CoA hydrolase || Carboxylic ester hydrolases || Thiolester hydrolases || 6-phosphogluconolactonase |
| Cysteine proteinases | 1 | INHERITED FROM: Poly(A)-specific ribonuclease || Exoribonucleases producing 5'-phosphomonoesters |
| Thiolase-like | 1 | INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase |
| DNA ligase/mRNA capping enzyme, catalytic domain | 1 | INHERITED FROM: Polynucleotide 5'-phosphatase |
| PDZ domain-like | 1 | INHERITED FROM: Protein-tyrosine-phosphatase || Phosphoric monoester hydrolases |
| ACT-like | 1 | INHERITED FROM: Diphosphoric monoester hydrolases || Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase |
| TGS-like | 1 | INHERITED FROM: Diphosphoric monoester hydrolases || Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase |
| Nucleotidyltransferase | 1 | INHERITED FROM: Diphosphoric monoester hydrolases || Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase |
| Nucleic acid-binding proteins | 1 | INHERITED FROM: Exoribonuclease II || Exoribonucleases producing 5'-phosphomonoesters || Ribonuclease E |
| dUTPase-like | 1 | INHERITED FROM: Retroviral ribonuclease H || Exoribonucleases producing 5'-phosphomonoesters || Exoribonuclease H |
| NAD(P)-binding Rossmann-fold domains | 1 | INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase |
| Concanavalin A-like lectins/glucanases | 1 | INHERITED FROM: Protein-tyrosine-phosphatase |
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| cAMP-binding domain-like | 0 | Direct |
| PH domain-like | 0 | Direct |
| tRNA-intron endonuclease N-terminal domain-like | 0 | Direct |
| Carbohydrate phosphatase | 0 | Direct |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0 | Direct |
| EF-hand | 0 | Direct |
| FabD/lysophospholipase-like | 0 | Direct |
| Purple acid phosphatase, N-terminal domain | 0 | Direct |
| Somatomedin B domain | 0 | Direct |
| AlbA-like | 0 | Direct |
| DNA/RNA polymerases | 0 | Direct |
| DNA-binding domain of retroviral integrase | 0 | Direct |
| Retrovirus capsid dimerization domain-like | 0 | Direct |
| Methylesterase CheB, C-terminal domain | 0 | Direct |
| Toprim domain | 0 | Direct |
| Phospholipase C/P1 nuclease | 0 | Direct |
| C-terminal domain of PLC-beta | 0 | Direct |
| XseB-like | 0 | Direct |
| CheY-like | 0 | Direct |
| GAF domain-like | 0 | Direct |
| Outer membrane phospholipase A (OMPLA) | 0 | Direct |
| (Phosphotyrosine protein) phosphatases II | 0 | Direct |
| tRNA-intron endonuclease catalytic domain-like | 0 | Direct |
| RNase A-like | 0 | Direct |
| Ribonuclease H-like | 0 | Direct |
| Plant invertase/pectin methylesterase inhibitor | 0 | Direct |
| Rof/RNase P subunit-like | 0 | Direct |
| Putative isomerase YbhE | 0 | Direct |
| Holliday junction resolvase RusA | 0 | Direct |
| Phosphoglycerate mutase-like | 0 | Direct |
| Rnp2-like | 0 | Direct |
| DNase I-like | 0 | Direct |
| Phospholipase A2, PLA2 | 0 | Direct |
| Ribosomal protein S5 domain 2-like | 0 | Direct |
| HAD-like | 0 | Direct |
| Phosphotyrosine protein phosphatases I | 0 | Direct |
| RNase III domain-like | 0 | Direct |
| Nitrous oxide reductase, N-terminal domain | 0 | Direct |
| His-Me finger endonucleases | 0 | Direct |
| Retroviral matrix proteins | 0 | Direct |
| Metallo-dependent phosphatases | 0 | Direct |
| SGNH hydrolase | 0 | Direct |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
| HD-domain/PDEase-like | 0 | Direct |
| Peptidyl-tRNA hydrolase domain-like | 0 | Direct |
| alpha/beta-Hydrolases | 0 | Direct |
| Peptidyl-tRNA hydrolase-like | 0 | Direct |
| Ribonuclease Rh-like | 0 | Direct |
| Retrovirus capsid protein, N-terminal core domain | 0 | Direct |
| Peptidyl-tRNA hydrolase II | 0 | Direct |
| L9 N-domain-like | 0 | Direct |
| Viral protein domain | 0 | Direct |
| SurE-like | 0 | Direct |
| Rhodanese/Cell cycle control phosphatase | 0 | Direct |
| ComB-like | 0 | Direct |
| Protein serine/threonine phosphatase 2C, C-terminal domain | 0 | Direct |
| Xylose isomerase-like | 0 | Direct |
| Metallo-hydrolase/oxidoreductase | 0 | Direct |
| PP2C-like | 0 | Direct |
| Acid phosphatase/Vanadium-dependent haloperoxidase | 0 | Direct |
| Microbial ribonucleases | 0 | Direct |
| Influenza hemagglutinin (stalk) | 0 | Direct |
| PLC-like phosphodiesterases | 0 | Direct |
| Retrovirus zinc finger-like domains | 0 | Direct |
| N-terminal Zn binding domain of HIV integrase | 0 | Direct |
| Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
| dsRNA-binding domain-like | 0 | Direct |
| Thermostable phytase (3-phytase) | 0 | Direct |
| Calcium-dependent phosphotriesterase | 0 | Direct |
| Phospholipase D/nuclease | 0 | Direct |
| WD40 repeat-like | 2.368e-16 | Direct |
| Fibronectin type III | 0.000000000000007826 | Direct |
| PHP domain-like | 0.0000000000003611 | Direct |
| Staphylococcal nuclease | 0.0000000001806 | Direct |
| 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain | 0.0000000004081 | Direct |
| DEK C-terminal domain | 0.000000002607 | Direct |
| EAL domain-like | 0.00000000504 | Direct |
| LigT-like | 0.000000006659 | Direct |
| Alkaline phosphatase-like | 0.000000006922 | Direct |
| Second domain of FERM | 0.00000002725 | Direct |
| PX domain | 0.0000005668 | Direct |
| Integrin alpha N-terminal domain | 0.000001942 | Direct |
| Saposin | 0.000003905 | Direct |
| SH2 domain | 0.000006817 | Direct |
| L domain-like | 0.00000756 | Direct |
| Acid proteases | 0.000008641 | Direct |
| CYTH-like phosphatases | 0.0001559 | Direct |
| Immunoglobulin | 0.0001702 | Direct |
| Pectin lyase-like | 0.0003098 | Direct |
| NTF2-like | 0.0006578 | Direct |
| HRDC-like | 0.001517 | Inherited |
| RNA-binding domain, RBD | 0.003436 | Inherited |
| Kelch motif | 0.007019 | Inherited |
| Ubiquitin-like | 0.0102 | Inherited |
| R3H domain | 0.03192 | Inherited |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.07992 | Inherited |
| Ankyrin repeat | 0.1213 | Inherited |
| DNA clamp | 0.1514 | Inherited |
| FYVE/PHD zinc finger | 0.2911 | Inherited |
| SH3-domain | 0.4052 | Inherited |
| Carbonic anhydrase | 0.4594 | Inherited |
| PYP-like sensor domain (PAS domain) | 0.4681 | Inherited |
| TPR-like | 0.5472 | Inherited |
| SAM/Pointed domain | 0.558 | Inherited |
| ACP-like | 0.6299 | Inherited |
| AraD/HMP-PK domain-like | 0.997 | Inherited |
| Restriction endonuclease-like | 1 | Inherited |
| P-loop containing nucleoside triphosphate hydrolases | 1 | Inherited |
| Macro domain-like | 1 | Inherited |
| S-adenosyl-L-methionine-dependent methyltransferases | 1 | Inherited |
| ClpP/crotonase | 1 | Inherited |
| GroES-like | 1 | Inherited |
| NagB/RpiA/CoA transferase-like | 1 | Inherited |
| Cysteine proteinases | 1 | Inherited |
| Thiolase-like | 1 | Inherited |
| DNA ligase/mRNA capping enzyme, catalytic domain | 1 | Inherited |
| PDZ domain-like | 1 | Inherited |
| ACT-like | 1 | Inherited |
| TGS-like | 1 | Inherited |
| Nucleotidyltransferase | 1 | Inherited |
| Nucleic acid-binding proteins | 1 | Inherited |
| dUTPase-like | 1 | Inherited |
| NAD(P)-binding Rossmann-fold domains | 1 | Inherited |
| Concanavalin A-like lectins/glucanases | 1 | Inherited |
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this (SDEO level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Mammalian PLC | 0 | DIRECT |
| 4HBT-like | 0 | DIRECT |
| DnaQ-like 3'-5' exonuclease | 0 | DIRECT |
| RuvC resolvase | 0 | DIRECT |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain | 0 | DIRECT |
| Pyrimidine 5'-nucleotidase (UMPH-1) | 0 | DIRECT |
| Vertebrate phospholipase A2 | 0 | DIRECT |
| Type 2 phosphatidic acid phosphatase, PAP2 | 0 | DIRECT |
| Thioesterases | 0 | DIRECT |
| Ribonuclease H | 0 | DIRECT |
| GlpX-like bacterial fructose-1,6-bisphosphatase | 0 | DIRECT |
| Pancreatic lipase, N-terminal domain | 0 | DIRECT |
| Phosphoserine phosphatase | 0 | DIRECT |
| Pectin methylesterase | 0 | DIRECT |
| Retrovirus zinc finger-like domains | 0 | DIRECT |
| RNase P subunit p29-like | 0 | DIRECT |
| N-terminal domain of RNase HI | 0 | DIRECT |
| Glyoxalase II (hydroxyacylglutathione hydrolase) | 0 | DIRECT |
| YfcE-like | 0 | DIRECT |
| Retrovirus capsid protein C-terminal domain | 0 | DIRECT |
| Patatin | 0 | DIRECT |
| Esterase domain of haemagglutinin-esterase-fusion glycoprotein HEF1 | 0 | DIRECT |
| Staphylococcal nuclease | 0 | DIRECT |
| EAL domain | 0 | DIRECT |
| Influenza hemagglutinin (stalk) | 0 | DIRECT |
| GpdQ-like | 0 | DIRECT |
| Rpp14/Pop5-like | 0 | DIRECT |
| 2',3'-cyclic nucleotide 3'-phosphodiesterase, catalytic domain | 0 | DIRECT |
| HD domain | 0 | DIRECT |
| Nuclease | 0 | DIRECT |
| RNB domain-like | 0 | DIRECT |
| CAF1-like ribonuclease | 0 | DIRECT |
| Higher-molecular-weight phosphotyrosine protein phosphatases | 0 | DIRECT |
| Arylsulfatase | 0 | DIRECT |
| Protein serine/threonine phosphatase | 0 | DIRECT |
| Histidinol phosphatase-like | 0 | DIRECT |
| N-terminal Zn binding domain of HIV integrase | 0 | DIRECT |
| Inositol monophosphatase/fructose-1,6-bisphosphatase-like | 0 | DIRECT |
| RNase III catalytic domain-like | 0 | DIRECT |
| Biotin biosynthesis protein BioH | 0 | DIRECT |
| Acetylcholinesterase-like | 0 | DIRECT |
| MtnX-like | 0 | DIRECT |
| Integrin alpha N-terminal domain | 0 | DIRECT |
| Myotubularin-like phosphatases | 0 | DIRECT |
| beta-Phosphoglucomutase-like | 0 | DIRECT |
| Enolase-phosphatase E1 | 0 | DIRECT |
| Methylesterase CheB, C-terminal domain | 0 | DIRECT |
| Immunodeficiency virus matrix proteins | 0 | DIRECT |
| Fungal ribonucleases | 0 | DIRECT |
| Purple acid phosphatase, N-terminal domain | 0 | DIRECT |
| Somatomedin B domain | 0 | DIRECT |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain | 0 | DIRECT |
| Dienelactone hydrolase | 0 | DIRECT |
| cAMP-binding domain | 0 | DIRECT |
| Peptidyl-tRNA hydrolase II | 0 | DIRECT |
| HTLV-II matrix protein | 0 | DIRECT |
| Outer membrane phospholipase A (OMPLA) | 0 | DIRECT |
| PDEase | 0 | DIRECT |
| Toprim domain | 0 | DIRECT |
| Glycerophosphoryl diester phosphodiesterase | 0 | DIRECT |
| Fungal lipases | 0 | DIRECT |
| PLC-like (P variant) | 0 | DIRECT |
| GAF domain | 0 | DIRECT |
| Ribonuclease A-like | 0 | DIRECT |
| SurE-like | 0 | DIRECT |
| Low-molecular-weight phosphotyrosine protein phosphatases | 0 | DIRECT |
| mRNA triphosphatase CET1 | 0 | DIRECT |
| EF-hand modules in multidomain proteins | 0 | DIRECT |
| Lysophospholipase | 0 | DIRECT |
| Protein serine/threonine phosphatase 2C, C-terminal domain | 0 | DIRECT |
| Holliday junction resolvase RusA | 0 | DIRECT |
| ComB-like | 0 | DIRECT |
| Hypothetical esterase YJL068C | 0 | DIRECT |
| 5' nucleotidase-like | 0 | DIRECT |
| Plant invertase/pectin methylesterase inhibitor | 0 | DIRECT |
| PP2C-like | 0 | DIRECT |
| Double-stranded RNA-binding domain (dsRBD) | 0 | DIRECT |
| Retroviral protease (retropepsin) | 0 | DIRECT |
| Predicted hydrolases Cof | 0 | DIRECT |
| C-terminal domain of PLC-beta | 0 | DIRECT |
| Alkaline phosphatase | 0 | DIRECT |
| Reverse transcriptase | 0 | DIRECT |
| Cutinase-like | 0 | DIRECT |
| Bacterial lipase | 0 | DIRECT |
| SGL-like | 0 | DIRECT |
| CheY-related | 0 | DIRECT |
| XseB-like | 0 | DIRECT |
| Nitrous oxide reductase, N-terminal domain | 0 | DIRECT |
| RNase P protein | 0 | DIRECT |
| Dual specificity phosphatase-like | 0 | DIRECT |
| Leucine rich effector protein YopM | 0 | DIRECT |
| Purple acid phosphatase-like | 0 | DIRECT |
| Histidine acid phosphatase | 0 | DIRECT |
| Endonuclease IV | 0 | DIRECT |
| Colipase-binding domain | 0 | DIRECT |
| Class B acid phosphatase, AphA | 0 | DIRECT |
| tRNA-intron endonuclease N-terminal domain-like | 0 | DIRECT |
| Peptidyl-tRNA hydrolase-like | 0 | DIRECT |
| NLI interacting factor-like phosphatase | 0 | DIRECT |
| DNA/RNA non-specific endonuclease | 0 | DIRECT |
| tRNA-intron endonuclease catalytic domain-like | 0 | DIRECT |
| Sphingomyelin phosphodiesterase-like | 0 | DIRECT |
| RNase D C-terminal domains | 0 | DIRECT |
| Retroviral integrase, catalytic domain | 0 | DIRECT |
| Retrovirus capsid protein, N-terminal core domain | 0 | DIRECT |
| Ribonuclease Rh-like | 0 | DIRECT |
| Peptidyl-tRNA hydrolase domain | 0 | DIRECT |
| Hemagglutinin domain of haemagglutinin-esterase-fusion glycoprotein HEF1 | 0 | DIRECT |
| Exodeoxyribonuclease V beta chain (RecC), C-terminal domain | 0 | DIRECT |
| GRAM domain | 0 | DIRECT |
| Alpha-toxin, C-terminal domain | 0 | DIRECT |
| Inositol polyphosphate 5-phosphatase (IPP5) | 0 | DIRECT |
| Insect phospholipase A2 | 0 | DIRECT |
| Cell cycle control phosphatase, catalytic domain | 0 | DIRECT |
| DNA-binding domain of retroviral integrase | 0 | DIRECT |
| Gastric lipase | 0 | DIRECT |
| RNase P subunit p30 | 0 | DIRECT |
| Phospholipase C | 0 | DIRECT |
| Serum paraoxonase/arylesterase 1, PON1 | 0 | DIRECT |
| RNase Z-like | 0 | DIRECT |
| Trehalose-phosphatase | 3.476e-16 | DIRECT |
| Fibronectin type III | 0.000000000000001381 | DIRECT |
| Carboxylesterase | 0.0000000000000546 | DIRECT |
| Cold shock DNA-binding domain-like | 0.000000000001445 | DIRECT |
| Pleckstrin-homology domain (PH domain) | 0.000000000001836 | DIRECT |
| DNase I-like | 0.000000000004773 | DIRECT |
| Third domain of FERM | 0.000000000007268 | DIRECT |
| Acetylhydrolase | 0.00000000001176 | DIRECT |
| 5'-nucleotidase (syn. UDP-sugar hydrolase), N-terminal domain | 0.0000000001597 | DIRECT |
| 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain | 0.0000000001597 | DIRECT |
| First domain of FERM | 0.000000000839 | DIRECT |
| Second domain of FERM | 0.000000009819 | DIRECT |
| Acyl-carrier protein (ACP) | 0.00000005434 | DIRECT |
| RelA/SpoT domain | 0.000000107 | DIRECT |
| DEK C-terminal domain | 0.000000354 | DIRECT |
| FYVE, a phosphatidylinositol-3-phosphate binding domain | 0.0000003973 | DIRECT |
| I set domains | 0.0000006059 | DIRECT |
| Imidazole glycerol phosphate dehydratase | 0.000001708 | DIRECT |
| Probable phosphatase YrbI | 0.000001866 | DIRECT |
| PDZ domain | 0.00000269 | DIRECT |
| SH2 domain | 0.000003398 | DIRECT |
| Thioesterase domain of polypeptide, polyketide and fatty acid synthases | 0.000003809 | DIRECT |
| Canonical RBD | 0.000006192 | DIRECT |
| CoA transferase alpha subunit-like | 0.00000728 | DIRECT |
| PX domain | 0.0000178 | DIRECT |
| MaoC-like | 0.0004252 | DIRECT |
| FabD-like | 0.0005874 | DIRECT |
| NagD-like | 0.0006084 | DIRECT |
| MAM domain | 0.007596 | INHERITED FROM: Protein-tyrosine-phosphatase || Phosphoric monoester hydrolases |
| R3H domain | 0.02304 | INHERITED FROM: Poly(A)-specific ribonuclease || Exoribonucleases producing 5'-phosphomonoesters |
| Macro domain | 0.03058 | INHERITED FROM: Phosphoric monoester hydrolases || ADP-ribose 1''-phosphate phosphatase || Polynucleotide 5'-phosphatase |
| Tetratricopeptide repeat (TPR) | 0.06133 | INHERITED FROM: Phosphoric monoester hydrolases || Phosphoprotein phosphatase |
| Ubiquitin-related | 0.06747 | INHERITED FROM: Phosphoric monoester hydrolases || Phosphoprotein phosphatase |
| Ankyrin repeat | 0.0886 | INHERITED FROM: Carboxylic ester hydrolases |
| Cofactor-dependent phosphoglycerate mutase | 0.08912 | INHERITED FROM: Fructose-2,6-bisphosphate 2-phosphatase || Phosphoric monoester hydrolases || Bisphosphoglycerate phosphatase |
| SAM (sterile alpha motif) domain | 0.2857 | INHERITED FROM: Phosphatidylinositol-3,4,5-trisphosphate 5-phospha |
| SH3-domain | 0.3399 | INHERITED FROM: Phosphoric diester hydrolases || Phosphoinositide phospholipase C |
| Carbonic anhydrase | 0.3985 | INHERITED FROM: Protein-tyrosine-phosphatase |
| DNA polymerase I | 0.472 | INHERITED FROM: Ribonuclease H || Endoribonucleases producing 5'-phosphomonoesters |
| Crotonase-like | 0.6802 | INHERITED FROM: Thiolester hydrolases || 3-hydroxyisobutyryl-CoA hydrolase |
| Carbon-carbon bond hydrolase | 0.8232 | INHERITED FROM: Acylglycerol lipase || Carboxylic ester hydrolases |
| AraD-like aldolase/epimerase | 0.895 | INHERITED FROM: Acireductone synthase |
| Tyrosine-dependent oxidoreductases | 1 | INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase |
| Thiolase-related | 1 | INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase || Thiolester hydrolases |
| dUTPase-like | 1 | INHERITED FROM: Retroviral ribonuclease H || Exoribonucleases producing 5'-phosphomonoesters || Exoribonuclease H |
| Tandem AAA-ATPase domain | 1 | INHERITED FROM: Exodeoxyribonucleases producing 5'-phosphomonoeste || Exodeoxyribonuclease V |
| Alcohol dehydrogenase-like, N-terminal domain | 1 | INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase || Thiolester hydrolases |
| Alcohol dehydrogenase-like, C-terminal domain | 1 | INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase || Thiolester hydrolases |
| Exodeoxyribonuclease V beta chain (RecB), C-terminal domain | 1 | INHERITED FROM: Exodeoxyribonucleases producing 5'-phosphomonoeste || Exodeoxyribonuclease V |
| NagB-like | 1 | INHERITED FROM: Carboxylic ester hydrolases || 6-phosphogluconolactonase |
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Mammalian PLC | 0 | Direct |
| 4HBT-like | 0 | Direct |
| DnaQ-like 3'-5' exonuclease | 0 | Direct |
| RuvC resolvase | 0 | Direct |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain | 0 | Direct |
| Pyrimidine 5'-nucleotidase (UMPH-1) | 0 | Direct |
| Vertebrate phospholipase A2 | 0 | Direct |
| Type 2 phosphatidic acid phosphatase, PAP2 | 0 | Direct |
| Thioesterases | 0 | Direct |
| Ribonuclease H | 0 | Direct |
| GlpX-like bacterial fructose-1,6-bisphosphatase | 0 | Direct |
| Pancreatic lipase, N-terminal domain | 0 | Direct |
| Phosphoserine phosphatase | 0 | Direct |
| Pectin methylesterase | 0 | Direct |
| Retrovirus zinc finger-like domains | 0 | Direct |
| RNase P subunit p29-like | 0 | Direct |
| N-terminal domain of RNase HI | 0 | Direct |
| Glyoxalase II (hydroxyacylglutathione hydrolase) | 0 | Direct |
| YfcE-like | 0 | Direct |
| Retrovirus capsid protein C-terminal domain | 0 | Direct |
| Patatin | 0 | Direct |
| Esterase domain of haemagglutinin-esterase-fusion glycoprotein HEF1 | 0 | Direct |
| Staphylococcal nuclease | 0 | Direct |
| EAL domain | 0 | Direct |
| Influenza hemagglutinin (stalk) | 0 | Direct |
| GpdQ-like | 0 | Direct |
| Rpp14/Pop5-like | 0 | Direct |
| 2',3'-cyclic nucleotide 3'-phosphodiesterase, catalytic domain | 0 | Direct |
| HD domain | 0 | Direct |
| Nuclease | 0 | Direct |
| RNB domain-like | 0 | Direct |
| CAF1-like ribonuclease | 0 | Direct |
| Higher-molecular-weight phosphotyrosine protein phosphatases | 0 | Direct |
| Arylsulfatase | 0 | Direct |
| Protein serine/threonine phosphatase | 0 | Direct |
| Histidinol phosphatase-like | 0 | Direct |
| N-terminal Zn binding domain of HIV integrase | 0 | Direct |
| Inositol monophosphatase/fructose-1,6-bisphosphatase-like | 0 | Direct |
| RNase III catalytic domain-like | 0 | Direct |
| Biotin biosynthesis protein BioH | 0 | Direct |
| Acetylcholinesterase-like | 0 | Direct |
| MtnX-like | 0 | Direct |
| Integrin alpha N-terminal domain | 0 | Direct |
| Myotubularin-like phosphatases | 0 | Direct |
| beta-Phosphoglucomutase-like | 0 | Direct |
| Enolase-phosphatase E1 | 0 | Direct |
| Methylesterase CheB, C-terminal domain | 0 | Direct |
| Immunodeficiency virus matrix proteins | 0 | Direct |
| Fungal ribonucleases | 0 | Direct |
| Purple acid phosphatase, N-terminal domain | 0 | Direct |
| Somatomedin B domain | 0 | Direct |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain | 0 | Direct |
| Dienelactone hydrolase | 0 | Direct |
| cAMP-binding domain | 0 | Direct |
| Peptidyl-tRNA hydrolase II | 0 | Direct |
| HTLV-II matrix protein | 0 | Direct |
| Outer membrane phospholipase A (OMPLA) | 0 | Direct |
| PDEase | 0 | Direct |
| Toprim domain | 0 | Direct |
| Glycerophosphoryl diester phosphodiesterase | 0 | Direct |
| Fungal lipases | 0 | Direct |
| PLC-like (P variant) | 0 | Direct |
| GAF domain | 0 | Direct |
| Ribonuclease A-like | 0 | Direct |
| SurE-like | 0 | Direct |
| Low-molecular-weight phosphotyrosine protein phosphatases | 0 | Direct |
| mRNA triphosphatase CET1 | 0 | Direct |
| EF-hand modules in multidomain proteins | 0 | Direct |
| Lysophospholipase | 0 | Direct |
| Protein serine/threonine phosphatase 2C, C-terminal domain | 0 | Direct |
| Holliday junction resolvase RusA | 0 | Direct |
| ComB-like | 0 | Direct |
| Hypothetical esterase YJL068C | 0 | Direct |
| 5' nucleotidase-like | 0 | Direct |
| Plant invertase/pectin methylesterase inhibitor | 0 | Direct |
| PP2C-like | 0 | Direct |
| Double-stranded RNA-binding domain (dsRBD) | 0 | Direct |
| Retroviral protease (retropepsin) | 0 | Direct |
| Predicted hydrolases Cof | 0 | Direct |
| C-terminal domain of PLC-beta | 0 | Direct |
| Alkaline phosphatase | 0 | Direct |
| Reverse transcriptase | 0 | Direct |
| Cutinase-like | 0 | Direct |
| Bacterial lipase | 0 | Direct |
| SGL-like | 0 | Direct |
| CheY-related | 0 | Direct |
| XseB-like | 0 | Direct |
| Nitrous oxide reductase, N-terminal domain | 0 | Direct |
| RNase P protein | 0 | Direct |
| Dual specificity phosphatase-like | 0 | Direct |
| Leucine rich effector protein YopM | 0 | Direct |
| Purple acid phosphatase-like | 0 | Direct |
| Histidine acid phosphatase | 0 | Direct |
| Endonuclease IV | 0 | Direct |
| Colipase-binding domain | 0 | Direct |
| Class B acid phosphatase, AphA | 0 | Direct |
| tRNA-intron endonuclease N-terminal domain-like | 0 | Direct |
| Peptidyl-tRNA hydrolase-like | 0 | Direct |
| NLI interacting factor-like phosphatase | 0 | Direct |
| DNA/RNA non-specific endonuclease | 0 | Direct |
| tRNA-intron endonuclease catalytic domain-like | 0 | Direct |
| Sphingomyelin phosphodiesterase-like | 0 | Direct |
| RNase D C-terminal domains | 0 | Direct |
| Retroviral integrase, catalytic domain | 0 | Direct |
| Retrovirus capsid protein, N-terminal core domain | 0 | Direct |
| Ribonuclease Rh-like | 0 | Direct |
| Peptidyl-tRNA hydrolase domain | 0 | Direct |
| Hemagglutinin domain of haemagglutinin-esterase-fusion glycoprotein HEF1 | 0 | Direct |
| Exodeoxyribonuclease V beta chain (RecC), C-terminal domain | 0 | Direct |
| GRAM domain | 0 | Direct |
| Alpha-toxin, C-terminal domain | 0 | Direct |
| Inositol polyphosphate 5-phosphatase (IPP5) | 0 | Direct |
| Insect phospholipase A2 | 0 | Direct |
| Cell cycle control phosphatase, catalytic domain | 0 | Direct |
| DNA-binding domain of retroviral integrase | 0 | Direct |
| Gastric lipase | 0 | Direct |
| RNase P subunit p30 | 0 | Direct |
| Phospholipase C | 0 | Direct |
| Serum paraoxonase/arylesterase 1, PON1 | 0 | Direct |
| RNase Z-like | 0 | Direct |
| Trehalose-phosphatase | 3.476e-16 | Direct |
| Fibronectin type III | 0.000000000000001381 | Direct |
| Carboxylesterase | 0.0000000000000546 | Direct |
| Cold shock DNA-binding domain-like | 0.000000000001445 | Direct |
| Pleckstrin-homology domain (PH domain) | 0.000000000001836 | Direct |
| DNase I-like | 0.000000000004773 | Direct |
| Third domain of FERM | 0.000000000007268 | Direct |
| Acetylhydrolase | 0.00000000001176 | Direct |
| 5'-nucleotidase (syn. UDP-sugar hydrolase), N-terminal domain | 0.0000000001597 | Direct |
| 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain | 0.0000000001597 | Direct |
| First domain of FERM | 0.000000000839 | Direct |
| Second domain of FERM | 0.000000009819 | Direct |
| Acyl-carrier protein (ACP) | 0.00000005434 | Direct |
| RelA/SpoT domain | 0.000000107 | Direct |
| DEK C-terminal domain | 0.000000354 | Direct |
| FYVE, a phosphatidylinositol-3-phosphate binding domain | 0.0000003973 | Direct |
| I set domains | 0.0000006059 | Direct |
| Imidazole glycerol phosphate dehydratase | 0.000001708 | Direct |
| Probable phosphatase YrbI | 0.000001866 | Direct |
| PDZ domain | 0.00000269 | Direct |
| SH2 domain | 0.000003398 | Direct |
| Thioesterase domain of polypeptide, polyketide and fatty acid synthases | 0.000003809 | Direct |
| Canonical RBD | 0.000006192 | Direct |
| CoA transferase alpha subunit-like | 0.00000728 | Direct |
| PX domain | 0.0000178 | Direct |
| MaoC-like | 0.0004252 | Direct |
| FabD-like | 0.0005874 | Direct |
| NagD-like | 0.0006084 | Direct |
| MAM domain | 0.007596 | Inherited |
| R3H domain | 0.02304 | Inherited |
| Macro domain | 0.03058 | Inherited |
| Tetratricopeptide repeat (TPR) | 0.06133 | Inherited |
| Ubiquitin-related | 0.06747 | Inherited |
| Ankyrin repeat | 0.0886 | Inherited |
| Cofactor-dependent phosphoglycerate mutase | 0.08912 | Inherited |
| SAM (sterile alpha motif) domain | 0.2857 | Inherited |
| SH3-domain | 0.3399 | Inherited |
| Carbonic anhydrase | 0.3985 | Inherited |
| DNA polymerase I | 0.472 | Inherited |
| Crotonase-like | 0.6802 | Inherited |
| Carbon-carbon bond hydrolase | 0.8232 | Inherited |
| AraD-like aldolase/epimerase | 0.895 | Inherited |
| Tyrosine-dependent oxidoreductases | 1 | Inherited |
| Thiolase-related | 1 | Inherited |
| dUTPase-like | 1 | Inherited |
| Tandem AAA-ATPase domain | 1 | Inherited |
| Alcohol dehydrogenase-like, N-terminal domain | 1 | Inherited |
| Alcohol dehydrogenase-like, C-terminal domain | 1 | Inherited |
| Exodeoxyribonuclease V beta chain (RecB), C-terminal domain | 1 | Inherited |
| NagB-like | 1 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this EC term
 |
Plot tree as:
| |
Download Newick format tree:
|
(show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this EC term (SPEO level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Plant invertase/pectin methylesterase inhibitor | 0 | DIRECT |
| DNase I-like | 0 | DIRECT |
| Outer membrane phospholipase A (OMPLA) | 0 | DIRECT |
| PH domain-like | 0 | DIRECT |
| N-terminal Zn binding domain of HIV integrase | 0 | DIRECT |
| PP2C-like | 0 | DIRECT |
| Voltage-gated potassium channels | 0 | DIRECT |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0 | DIRECT |
| Ribonuclease H-like | 0 | DIRECT |
| Influenza hemagglutinin (stalk) | 0 | DIRECT |
| tRNA-intron endonuclease N-terminal domain-like | 0 | DIRECT |
| EF-hand | 0 | DIRECT |
| L9 N-domain-like | 0 | DIRECT |
| Retroviral matrix proteins | 0 | DIRECT |
| Phosphoglycerate mutase-like | 0 | DIRECT |
| Retrovirus zinc finger-like domains | 0 | DIRECT |
| AlbA-like | 0 | DIRECT |
| Bacterial GAP domain | 0 | DIRECT |
| Carbohydrate phosphatase | 0 | DIRECT |
| Holliday junction resolvase RusA | 0 | DIRECT |
| CRAL/TRIO N-terminal domain | 0 | DIRECT |
| Calcium-dependent phosphotriesterase | 0 | DIRECT |
| Rof/RNase P subunit-like | 0 | DIRECT |
| Phospholipase C/P1 nuclease | 0 | DIRECT |
| HD-domain/PDEase-like | 0 | DIRECT |
| Putative isomerase YbhE | 0 | DIRECT |
| HAD-like | 0 | DIRECT |
| Protein serine/threonine phosphatase 2C, C-terminal domain | 0 | DIRECT |
| PLC-like phosphodiesterases | 0 | DIRECT |
| His-Me finger endonucleases | 0 | DIRECT |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
| RNase A-like | 0 | DIRECT |
| DNA-binding domain of retroviral integrase | 0 | DIRECT |
| Toprim domain | 0 | DIRECT |
| Metallo-hydrolase/oxidoreductase | 0 | DIRECT |
| Rnp2-like | 0 | DIRECT |
| Metallo-dependent phosphatases | 0 | DIRECT |
| alpha/beta-Hydrolases | 0 | DIRECT |
| RNase III domain-like | 0 | DIRECT |
| (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
| Viral protein domain | 0 | DIRECT |
| Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
| Rhodanese/Cell cycle control phosphatase | 0 | DIRECT |
| SGNH hydrolase | 0 | DIRECT |
| Peptidyl-tRNA hydrolase domain-like | 0 | DIRECT |
| Ribonuclease Rh-like | 0 | DIRECT |
| FabD/lysophospholipase-like | 0 | DIRECT |
| Retrovirus capsid protein, N-terminal core domain | 0 | DIRECT |
| Peptidyl-tRNA hydrolase-like | 0 | DIRECT |
| dsRNA-binding domain-like | 0 | DIRECT |
| Purple acid phosphatase, N-terminal domain | 0 | DIRECT |
| Microbial ribonucleases | 0 | DIRECT |
| Thermostable phytase (3-phytase) | 0 | DIRECT |
| GAF domain-like | 0 | DIRECT |
| Xylose isomerase-like | 0 | DIRECT |
| Somatomedin B domain | 0 | DIRECT |
| XseB-like | 0 | DIRECT |
| ComB-like | 0 | DIRECT |
| Peptidyl-tRNA hydrolase II | 0 | DIRECT |
| Phosphotyrosine protein phosphatases I | 0 | DIRECT |
| C-terminal domain of PLC-beta | 0 | DIRECT |
| Retrovirus capsid dimerization domain-like | 0 | DIRECT |
| Acid phosphatase/Vanadium-dependent haloperoxidase | 0 | DIRECT |
| Ribosomal protein S5 domain 2-like | 0 | DIRECT |
| Phospholipase A2, PLA2 | 0 | DIRECT |
| Nitrous oxide reductase, N-terminal domain | 0 | DIRECT |
| DNA/RNA polymerases | 0 | DIRECT |
| Phospholipase D/nuclease | 0 | DIRECT |
| cAMP-binding domain-like | 0 | DIRECT |
| SurE-like | 0 | DIRECT |
| Methylesterase CheB, C-terminal domain | 0 | DIRECT |
| tRNA-intron endonuclease catalytic domain-like | 0 | DIRECT |
| CheY-like | 0 | DIRECT |
| WD40 repeat-like | 1.756e-16 | DIRECT |
| Fibronectin type III | 0.000000000000006742 | DIRECT |
| PHP domain-like | 0.0000000000002915 | DIRECT |
| Staphylococcal nuclease | 0.0000000001439 | DIRECT |
| 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain | 0.0000000003387 | DIRECT |
| DEK C-terminal domain | 0.000000002098 | DIRECT |
| EAL domain-like | 0.000000004062 | DIRECT |
| LigT-like | 0.000000005519 | DIRECT |
| Alkaline phosphatase-like | 0.000000005968 | DIRECT |
| Second domain of FERM | 0.00000002232 | DIRECT |
| PX domain | 0.0000004686 | DIRECT |
| CYTH-like phosphatases | 0.0000007193 | DIRECT |
| Integrin alpha N-terminal domain | 0.000001604 | DIRECT |
| Saposin | 0.000003294 | DIRECT |
| SH2 domain | 0.000005807 | DIRECT |
| L domain-like | 0.000006477 | DIRECT |
| Acid proteases | 0.000008081 | DIRECT |
| Ras GEF | 0.00007977 | DIRECT |
| Immunoglobulin | 0.0001477 | DIRECT |
| Chaperone J-domain | 0.0002247 | DIRECT |
| GTPase activation domain, GAP | 0.0002247 | DIRECT |
| Pectin lyase-like | 0.0002904 | DIRECT |
| NTF2-like | 0.000569 | DIRECT |
| HRDC-like | 0.001348 | INHERITED FROM: Ribonuclease D || Exoribonucleases producing 5'-phosphomonoesters |
| CRAL/TRIO domain | 0.00159 | INHERITED FROM: Protein-tyrosine-phosphatase || Phosphoric monoester hydrolases |
| RNA-binding domain, RBD | 0.003049 | INHERITED FROM: Phosphoinositide 5-phosphatase || Poly(A)-specific ribonuclease || Exoribonucleases producing 5'-phosphomonoesters |
| Kelch motif | 0.00616 | INHERITED FROM: Phosphoric monoester hydrolases || Phosphoprotein phosphatase |
| Ubiquitin-like | 0.009215 | INHERITED FROM: Protein-tyrosine-phosphatase || Phosphoric monoester hydrolases || Phosphoinositide phospholipase C |
| Non-globular alpha+beta subunits of globular proteins | 0.02412 | INHERITED FROM: Protein-tyrosine-phosphatase || Phosphoric monoester hydrolases |
| R3H domain | 0.02864 | INHERITED FROM: Poly(A)-specific ribonuclease || Exoribonucleases producing 5'-phosphomonoesters |
| SMAD/FHA domain | 0.03304 | INHERITED FROM: Phosphoric monoester hydrolases |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.07215 | INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase || Thiolester hydrolases |
| PIN domain-like | 0.08088 | INHERITED FROM: Exodeoxyribonucleases producing 5'-phosphomonoeste || Exodeoxyribonuclease (lambda-induced) |
| DNA clamp | 0.138 | INHERITED FROM: Exodeoxyribonucleases producing 5'-phosphomonoeste || Exodeoxyribonuclease III |
| Ankyrin repeat | 0.1406 | INHERITED FROM: Glycerophosphodiester phosphodiesterase || Carboxylic ester hydrolases || 1-alkyl-2-acetylglycerophosphocholine esterase || Lysophospholipase |
| L30e-like | 0.1678 | INHERITED FROM: Ribonuclease P |
| Methylated DNA-protein cysteine methyltransferase, C-terminal domain | 0.2191 | INHERITED FROM: Endodeoxyribonucleases producing 5'-phosphomonoest || Deoxyribonuclease V |
| Bet v1-like | 0.2351 | INHERITED FROM: Acetyl-CoA hydrolase || Thiolester hydrolases |
| Autotransporter | 0.2452 | INHERITED FROM: Carboxylic ester hydrolases |
| Quinoprotein alcohol dehydrogenase-like | 0.2636 | INHERITED FROM: Poly(A)-specific ribonuclease || Exoribonucleases producing 5'-phosphomonoesters |
| FYVE/PHD zinc finger | 0.2701 | INHERITED FROM: Protein-tyrosine-phosphatase || Phosphoric monoester hydrolases |
| SH3-domain | 0.3777 | INHERITED FROM: Phosphoric diester hydrolases || Phosphoinositide phospholipase C |
| Starch-binding domain-like | 0.4012 | INHERITED FROM: Protein-tyrosine-phosphatase || Glycerophosphocholine phosphodiesterase || Phosphoric diester hydrolases || Phosphoprotein phosphatase |
| Carbonic anhydrase | 0.4295 | INHERITED FROM: Protein-tyrosine-phosphatase |
| PYP-like sensor domain (PAS domain) | 0.4383 | INHERITED FROM: 3',5'-cyclic-nucleotide phosphodiesterase || Phosphoric diester hydrolases |
| TPR-like | 0.5135 | INHERITED FROM: Phosphoprotein phosphatase |
| SAM/Pointed domain | 0.5236 | INHERITED FROM: Phosphatidylinositol-3,4,5-trisphosphate 5-phospha |
| ACP-like | 0.5919 | INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase || Thiolester hydrolases |
| AraD/HMP-PK domain-like | 0.9434 | INHERITED FROM: Acireductone synthase |
| dUTPase-like | 1 | INHERITED FROM: Retroviral ribonuclease H || Exoribonucleases producing 5'-phosphomonoesters || Exoribonuclease H |
| NAD(P)-binding Rossmann-fold domains | 1 | INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase |
| Glutaminase/Asparaginase | 1 | INHERITED FROM: Carboxylic ester hydrolases || 1-alkyl-2-acetylglycerophosphocholine esterase || Lysophospholipase |
| DNA ligase/mRNA capping enzyme, catalytic domain | 1 | INHERITED FROM: Polynucleotide 5'-phosphatase |
| GroES-like | 1 | INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase || Thiolester hydrolases |
| NagB/RpiA/CoA transferase-like | 1 | INHERITED FROM: Acetyl-CoA hydrolase || Carboxylic ester hydrolases || Thiolester hydrolases || 6-phosphogluconolactonase |
| UDP-Glycosyltransferase/glycogen phosphorylase | 1 | INHERITED FROM: Trehalose-phosphatase |
| Nucleic acid-binding proteins | 1 | INHERITED FROM: Exoribonuclease II || Exoribonucleases producing 5'-phosphomonoesters || Ribonuclease E |
| Restriction endonuclease-like | 1 | INHERITED FROM: Endodeoxyribonucleases producing 5'-phosphomonoest || Exodeoxyribonucleases producing 5'-phosphomonoeste || Type II site-specific deoxyribonuclease || Exodeoxyribonuclease V |
| S-adenosyl-L-methionine-dependent methyltransferases | 1 | INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase || Polynucleotide 5'-phosphatase |
| ACT-like | 1 | INHERITED FROM: Diphosphoric monoester hydrolases || Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase |
| TGS-like | 1 | INHERITED FROM: Diphosphoric monoester hydrolases || Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase |
| PDZ domain-like | 1 | INHERITED FROM: Protein-tyrosine-phosphatase || Phosphoric monoester hydrolases |
| P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: Fructose-2,6-bisphosphate 2-phosphatase || Type III site-specific deoxyribonuclease || Type I site-specific deoxyribonuclease || Exodeoxyribonuclease V || Polynucleotide 5'-phosphatase || Polynucleotide 3'-phosphatase |
| Concanavalin A-like lectins/glucanases | 1 | INHERITED FROM: Protein-tyrosine-phosphatase || Lysophospholipase |
| ClpP/crotonase | 1 | INHERITED FROM: Thiolester hydrolases || 3-hydroxyisobutyryl-CoA hydrolase |
| Nucleotidyltransferase | 1 | INHERITED FROM: Diphosphoric monoester hydrolases || Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase |
| Thiolase-like | 1 | INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase |
| Macro domain-like | 1 | INHERITED FROM: Phosphoric monoester hydrolases || ADP-ribose 1''-phosphate phosphatase || Polynucleotide 5'-phosphatase |
| Cysteine proteinases | 1 | INHERITED FROM: Poly(A)-specific ribonuclease || Exoribonucleases producing 5'-phosphomonoesters |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Plant invertase/pectin methylesterase inhibitor | 0 | Direct |
| DNase I-like | 0 | Direct |
| Outer membrane phospholipase A (OMPLA) | 0 | Direct |
| PH domain-like | 0 | Direct |
| N-terminal Zn binding domain of HIV integrase | 0 | Direct |
| PP2C-like | 0 | Direct |
| Voltage-gated potassium channels | 0 | Direct |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0 | Direct |
| Ribonuclease H-like | 0 | Direct |
| Influenza hemagglutinin (stalk) | 0 | Direct |
| tRNA-intron endonuclease N-terminal domain-like | 0 | Direct |
| EF-hand | 0 | Direct |
| L9 N-domain-like | 0 | Direct |
| Retroviral matrix proteins | 0 | Direct |
| Phosphoglycerate mutase-like | 0 | Direct |
| Retrovirus zinc finger-like domains | 0 | Direct |
| AlbA-like | 0 | Direct |
| Bacterial GAP domain | 0 | Direct |
| Carbohydrate phosphatase | 0 | Direct |
| Holliday junction resolvase RusA | 0 | Direct |
| CRAL/TRIO N-terminal domain | 0 | Direct |
| Calcium-dependent phosphotriesterase | 0 | Direct |
| Rof/RNase P subunit-like | 0 | Direct |
| Phospholipase C/P1 nuclease | 0 | Direct |
| HD-domain/PDEase-like | 0 | Direct |
| Putative isomerase YbhE | 0 | Direct |
| HAD-like | 0 | Direct |
| Protein serine/threonine phosphatase 2C, C-terminal domain | 0 | Direct |
| PLC-like phosphodiesterases | 0 | Direct |
| His-Me finger endonucleases | 0 | Direct |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
| RNase A-like | 0 | Direct |
| DNA-binding domain of retroviral integrase | 0 | Direct |
| Toprim domain | 0 | Direct |
| Metallo-hydrolase/oxidoreductase | 0 | Direct |
| Rnp2-like | 0 | Direct |
| Metallo-dependent phosphatases | 0 | Direct |
| alpha/beta-Hydrolases | 0 | Direct |
| RNase III domain-like | 0 | Direct |
| (Phosphotyrosine protein) phosphatases II | 0 | Direct |
| Viral protein domain | 0 | Direct |
| Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
| Rhodanese/Cell cycle control phosphatase | 0 | Direct |
| SGNH hydrolase | 0 | Direct |
| Peptidyl-tRNA hydrolase domain-like | 0 | Direct |
| Ribonuclease Rh-like | 0 | Direct |
| FabD/lysophospholipase-like | 0 | Direct |
| Retrovirus capsid protein, N-terminal core domain | 0 | Direct |
| Peptidyl-tRNA hydrolase-like | 0 | Direct |
| dsRNA-binding domain-like | 0 | Direct |
| Purple acid phosphatase, N-terminal domain | 0 | Direct |
| Microbial ribonucleases | 0 | Direct |
| Thermostable phytase (3-phytase) | 0 | Direct |
| GAF domain-like | 0 | Direct |
| Xylose isomerase-like | 0 | Direct |
| Somatomedin B domain | 0 | Direct |
| XseB-like | 0 | Direct |
| ComB-like | 0 | Direct |
| Peptidyl-tRNA hydrolase II | 0 | Direct |
| Phosphotyrosine protein phosphatases I | 0 | Direct |
| C-terminal domain of PLC-beta | 0 | Direct |
| Retrovirus capsid dimerization domain-like | 0 | Direct |
| Acid phosphatase/Vanadium-dependent haloperoxidase | 0 | Direct |
| Ribosomal protein S5 domain 2-like | 0 | Direct |
| Phospholipase A2, PLA2 | 0 | Direct |
| Nitrous oxide reductase, N-terminal domain | 0 | Direct |
| DNA/RNA polymerases | 0 | Direct |
| Phospholipase D/nuclease | 0 | Direct |
| cAMP-binding domain-like | 0 | Direct |
| SurE-like | 0 | Direct |
| Methylesterase CheB, C-terminal domain | 0 | Direct |
| tRNA-intron endonuclease catalytic domain-like | 0 | Direct |
| CheY-like | 0 | Direct |
| WD40 repeat-like | 1.756e-16 | Direct |
| Fibronectin type III | 0.000000000000006742 | Direct |
| PHP domain-like | 0.0000000000002915 | Direct |
| Staphylococcal nuclease | 0.0000000001439 | Direct |
| 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain | 0.0000000003387 | Direct |
| DEK C-terminal domain | 0.000000002098 | Direct |
| EAL domain-like | 0.000000004062 | Direct |
| LigT-like | 0.000000005519 | Direct |
| Alkaline phosphatase-like | 0.000000005968 | Direct |
| Second domain of FERM | 0.00000002232 | Direct |
| PX domain | 0.0000004686 | Direct |
| CYTH-like phosphatases | 0.0000007193 | Direct |
| Integrin alpha N-terminal domain | 0.000001604 | Direct |
| Saposin | 0.000003294 | Direct |
| SH2 domain | 0.000005807 | Direct |
| L domain-like | 0.000006477 | Direct |
| Acid proteases | 0.000008081 | Direct |
| Ras GEF | 0.00007977 | Direct |
| Immunoglobulin | 0.0001477 | Direct |
| Chaperone J-domain | 0.0002247 | Direct |
| GTPase activation domain, GAP | 0.0002247 | Direct |
| Pectin lyase-like | 0.0002904 | Direct |
| NTF2-like | 0.000569 | Direct |
| HRDC-like | 0.001348 | Inherited |
| CRAL/TRIO domain | 0.00159 | Inherited |
| RNA-binding domain, RBD | 0.003049 | Inherited |
| Kelch motif | 0.00616 | Inherited |
| Ubiquitin-like | 0.009215 | Inherited |
| Non-globular alpha+beta subunits of globular proteins | 0.02412 | Inherited |
| R3H domain | 0.02864 | Inherited |
| SMAD/FHA domain | 0.03304 | Inherited |
| Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.07215 | Inherited |
| PIN domain-like | 0.08088 | Inherited |
| DNA clamp | 0.138 | Inherited |
| Ankyrin repeat | 0.1406 | Inherited |
| L30e-like | 0.1678 | Inherited |
| Methylated DNA-protein cysteine methyltransferase, C-terminal domain | 0.2191 | Inherited |
| Bet v1-like | 0.2351 | Inherited |
| Autotransporter | 0.2452 | Inherited |
| Quinoprotein alcohol dehydrogenase-like | 0.2636 | Inherited |
| FYVE/PHD zinc finger | 0.2701 | Inherited |
| SH3-domain | 0.3777 | Inherited |
| Starch-binding domain-like | 0.4012 | Inherited |
| Carbonic anhydrase | 0.4295 | Inherited |
| PYP-like sensor domain (PAS domain) | 0.4383 | Inherited |
| TPR-like | 0.5135 | Inherited |
| SAM/Pointed domain | 0.5236 | Inherited |
| ACP-like | 0.5919 | Inherited |
| AraD/HMP-PK domain-like | 0.9434 | Inherited |
| dUTPase-like | 1 | Inherited |
| NAD(P)-binding Rossmann-fold domains | 1 | Inherited |
| Glutaminase/Asparaginase | 1 | Inherited |
| DNA ligase/mRNA capping enzyme, catalytic domain | 1 | Inherited |
| GroES-like | 1 | Inherited |
| NagB/RpiA/CoA transferase-like | 1 | Inherited |
| UDP-Glycosyltransferase/glycogen phosphorylase | 1 | Inherited |
| Nucleic acid-binding proteins | 1 | Inherited |
| Restriction endonuclease-like | 1 | Inherited |
| S-adenosyl-L-methionine-dependent methyltransferases | 1 | Inherited |
| ACT-like | 1 | Inherited |
| TGS-like | 1 | Inherited |
| PDZ domain-like | 1 | Inherited |
| P-loop containing nucleoside triphosphate hydrolases | 1 | Inherited |
| Concanavalin A-like lectins/glucanases | 1 | Inherited |
| ClpP/crotonase | 1 | Inherited |
| Nucleotidyltransferase | 1 | Inherited |
| Thiolase-like | 1 | Inherited |
| Macro domain-like | 1 | Inherited |
| Cysteine proteinases | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEO level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
82708,53098
82708 - R3H domain
53098 - Ribonuclease H-like | 0 | DIRECT |
47353,57756
47353 - Retrovirus capsid dimerization domain-like
57756 - Retrovirus zinc finger-like domains | 0 | DIRECT |
53098,53098
53098 - Ribonuclease H-like
53098 - Ribonuclease H-like | 0 | DIRECT |
56219,54928
56219 - DNase I-like
54928 - RNA-binding domain, RBD | 0 | DIRECT |
56784,54427
56784 - HAD-like
54427 - NTF2-like | 0 | DIRECT |
50156,52799
50156 - PDZ domain-like
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
47473,51695
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | DIRECT |
53474,49723
53474 - alpha/beta-Hydrolases
49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0 | DIRECT |
46938,52087
46938 - CRAL/TRIO N-terminal domain
52087 - CRAL/TRIO domain | 0 | DIRECT |
57756,50630
57756 - Retrovirus zinc finger-like domains
50630 - Acid proteases | 0 | DIRECT |
49562,52151
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
52151 - FabD/lysophospholipase-like | 0 | DIRECT |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0 | DIRECT |
51283,46919
51283 - dUTPase-like
46919 - N-terminal Zn binding domain of HIV integrase | 0 | DIRECT |
48452,56300
48452 - TPR-like
56300 - Metallo-dependent phosphatases | 0 | DIRECT |
54001,53098
54001 - Cysteine proteinases
53098 - Ribonuclease H-like | 0 | DIRECT |
52540,55144
52540 - P-loop containing nucleoside triphosphate hydrolases
55144 - LigT-like | 0 | DIRECT |
54637,55961
54637 - Thioesterase/thiol ester dehydrase-isomerase
55961 - Bet v1-like | 0 | DIRECT |
81324,52799
81324 - Voltage-gated potassium channels
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
48537,49723
48537 - Phospholipase C/P1 nuclease
49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0 | DIRECT |
56784,54211
56784 - HAD-like
54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
81606,81601
81606 - PP2C-like
81601 - Protein serine/threonine phosphatase 2C, C-terminal domain | 0 | DIRECT |
52540,53254
52540 - P-loop containing nucleoside triphosphate hydrolases
53254 - Phosphoglycerate mutase-like | 0 | DIRECT |
69065,54768
69065 - RNase III domain-like
54768 - dsRNA-binding domain-like | 0 | DIRECT |
101908,56219
101908 - Putative isomerase YbhE
56219 - DNase I-like | 0 | DIRECT |
52266,49818
52266 - SGNH hydrolase
49818 - Viral protein domain | 0 | DIRECT |
53098,54928
53098 - Ribonuclease H-like
54928 - RNA-binding domain, RBD | 0 | DIRECT |
49562,56024
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
56024 - Phospholipase D/nuclease | 0 | DIRECT |
47943,47353
47943 - Retrovirus capsid protein, N-terminal core domain
47353 - Retrovirus capsid dimerization domain-like | 0 | DIRECT |
55781,109604
55781 - GAF domain-like
109604 - HD-domain/PDEase-like | 0 | DIRECT |
56784,56784
56784 - HAD-like
56784 - HAD-like | 0 | DIRECT |
47233,52799
47233 - Bacterial GAP domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
51695,49562
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
53098,51283
53098 - Ribonuclease H-like
51283 - dUTPase-like | 0 | DIRECT |
55658,53098
55658 - L9 N-domain-like
53098 - Ribonuclease H-like | 0 | DIRECT |
47819,47819
47819 - HRDC-like
47819 - HRDC-like | 0 | DIRECT |
50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
46919,53098
46919 - N-terminal Zn binding domain of HIV integrase
53098 - Ribonuclease H-like | 0 | DIRECT |
49363,56300
49363 - Purple acid phosphatase, N-terminal domain
56300 - Metallo-dependent phosphatases | 0 | DIRECT |
49452,52799
49452 - Starch-binding domain-like
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
51695,51695
51695 - PLC-like phosphodiesterases
51695 - PLC-like phosphodiesterases | 0 | DIRECT |
53098,46919
53098 - Ribonuclease H-like
46919 - N-terminal Zn binding domain of HIV integrase | 0 | DIRECT |
49899,48726
49899 - Concanavalin A-like lectins/glucanases
48726 - Immunoglobulin | 0 | DIRECT |
52058,56219
52058 - L domain-like
56219 - DNase I-like | 0 | DIRECT |
52799,52799
52799 - (Phosphotyrosine protein) phosphatases II
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
90188,53649
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like | 0 | DIRECT |
52799,56091
52799 - (Phosphotyrosine protein) phosphatases II
56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
53639,56784
53639 - AraD/HMP-PK domain-like
56784 - HAD-like | 0 | DIRECT |
54637,52151
54637 - Thioesterase/thiol ester dehydrase-isomerase
52151 - FabD/lysophospholipase-like | 0 | DIRECT |
51069,49265
51069 - Carbonic anhydrase
49265 - Fibronectin type III | 0 | DIRECT |
101148,51126
101148 - Plant invertase/pectin methylesterase inhibitor
51126 - Pectin lyase-like | 0 | DIRECT |
55267,53032
55267 - tRNA-intron endonuclease N-terminal domain-like
53032 - tRNA-intron endonuclease catalytic domain-like | 0 | DIRECT |
90188,90188
90188 - Somatomedin B domain
90188 - Somatomedin B domain | 0 | DIRECT |
52151,52151
52151 - FabD/lysophospholipase-like
52151 - FabD/lysophospholipase-like | 0 | DIRECT |
52172,52738
52172 - CheY-like
52738 - Methylesterase CheB, C-terminal domain | 0 | DIRECT |
50044,51695
50044 - SH3-domain
51695 - PLC-like phosphodiesterases | 0 | DIRECT |
53032,55267
53032 - tRNA-intron endonuclease catalytic domain-like
55267 - tRNA-intron endonuclease N-terminal domain-like | 0 | DIRECT |
50974,50974
50974 - Nitrous oxide reductase, N-terminal domain
50974 - Nitrous oxide reductase, N-terminal domain | 0 | DIRECT |
56672,53098
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like | 0 | DIRECT |
50630,56672
50630 - Acid proteases
56672 - DNA/RNA polymerases | 0 | DIRECT |
52266,103515
52266 - SGNH hydrolase
103515 - Autotransporter | 0 | DIRECT |
52821,52799
52821 - Rhodanese/Cell cycle control phosphatase
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
52087,52799
52087 - CRAL/TRIO domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
53098,50122
53098 - Ribonuclease H-like
50122 - DNA-binding domain of retroviral integrase | 0 | DIRECT |
53649,54060
53649 - Alkaline phosphatase-like
54060 - His-Me finger endonucleases | 0 | DIRECT |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0 | DIRECT |
69065,69065
69065 - RNase III domain-like
69065 - RNase III domain-like | 0 | DIRECT |
55550,52799
55550 - SH2 domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
56300,47473
56300 - Metallo-dependent phosphatases
47473 - EF-hand | 0 | DIRECT |
56300,56300
56300 - Metallo-dependent phosphatases
56300 - Metallo-dependent phosphatases | 0 | DIRECT |
56784,52540
56784 - HAD-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
47836,47943
47836 - Retroviral matrix proteins
47943 - Retrovirus capsid protein, N-terminal core domain | 0 | DIRECT |
53098,47819
53098 - Ribonuclease H-like
47819 - HRDC-like | 0 | DIRECT |
51206,51206
51206 - cAMP-binding domain-like
51206 - cAMP-binding domain-like | 0 | DIRECT |
50729,56024
50729 - PH domain-like
56024 - Phospholipase D/nuclease | 0 | DIRECT |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0 | DIRECT |
48403,52151
48403 - Ankyrin repeat
52151 - FabD/lysophospholipase-like | 0 | DIRECT |
54236,56784
54236 - Ubiquitin-like
56784 - HAD-like | 0 | DIRECT |
50729,52799
50729 - PH domain-like
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
49562,54236
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
54236 - Ubiquitin-like | 0 | DIRECT |
55154,56091
55154 - CYTH-like phosphatases
56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
109715,52799
109715 - DEK C-terminal domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
56568,47233
56568 - Non-globular alpha+beta subunits of globular proteins
47233 - Bacterial GAP domain | 0 | DIRECT |
55781,55781
55781 - GAF domain-like
55781 - GAF domain-like | 0 | DIRECT |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0.000000000000002433 | DIRECT |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.000000000000005366 | DIRECT |
52799,49562
52799 - (Phosphotyrosine protein) phosphatases II
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.000000000003954 | DIRECT |
54236,47031
54236 - Ubiquitin-like
47031 - Second domain of FERM | 0.00000000001061 | DIRECT |
64268,50729
64268 - PX domain
50729 - PH domain-like | 0.00000000001548 | DIRECT |
54637,54637
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0.000000000264 | DIRECT |
56300,55816
56300 - Metallo-dependent phosphatases
55816 - 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain | 0.0000000003387 | DIRECT |
47031,50729
47031 - Second domain of FERM
50729 - PH domain-like | 0.0000000009723 | DIRECT |
53474,53474
53474 - alpha/beta-Hydrolases
53474 - alpha/beta-Hydrolases | 0.000000001537 | DIRECT |
109604,81301
109604 - HD-domain/PDEase-like
81301 - Nucleotidyltransferase | 0.00000006187 | DIRECT |
100950,100950
100950 - NagB/RpiA/CoA transferase-like
100950 - NagB/RpiA/CoA transferase-like | 0.00000006235 | DIRECT |
56024,56024
56024 - Phospholipase D/nuclease
56024 - Phospholipase D/nuclease | 0.0000002495 | DIRECT |
47336,53474
47336 - ACP-like
53474 - alpha/beta-Hydrolases | 0.0000004283 | DIRECT |
81301,81271
81301 - Nucleotidyltransferase
81271 - TGS-like | 0.000002717 | DIRECT |
54211,54211
54211 - Ribosomal protein S5 domain 2-like
54211 - Ribosomal protein S5 domain 2-like | 0.000004075 | DIRECT |
54236,54236
54236 - Ubiquitin-like
54236 - Ubiquitin-like | 0.0000171 | DIRECT |
53335,52949
53335 - S-adenosyl-L-methionine-dependent methyltransferases
52949 - Macro domain-like | 0.00004213 | DIRECT |
53474,53335
53474 - alpha/beta-Hydrolases
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0.00007977 | DIRECT |
51735,47336
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like | 0.001882 | INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase || Thiolester hydrolases |
51735,51735
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains | 0.005683 | INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase || Thiolester hydrolases |
53774,48403
53774 - Glutaminase/Asparaginase
48403 - Ankyrin repeat | 0.006896 | INHERITED FROM: Carboxylic ester hydrolases || 1-alkyl-2-acetylglycerophosphocholine esterase || Lysophospholipase |
53756,56784
53756 - UDP-Glycosyltransferase/glycogen phosphorylase
56784 - HAD-like | 0.008587 | INHERITED FROM: Phosphoric monoester hydrolases || Trehalose-phosphatase |
52058,52058
52058 - L domain-like
52058 - L domain-like | 0.01532 | INHERITED FROM: Phosphoric monoester hydrolases || Phosphoprotein phosphatase |
52151,55048
52151 - FabD/lysophospholipase-like
55048 - Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.07215 | INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase || Thiolester hydrolases |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.07747 | INHERITED FROM: Protein-tyrosine-phosphatase || Phosphoric monoester hydrolases |
53098,56672
53098 - Ribonuclease H-like
56672 - DNA/RNA polymerases | 0.2839 | INHERITED FROM: Ribonuclease H || Endoribonucleases producing 5'-phosphomonoesters |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: Endodeoxyribonucleases producing 5'-phosphomonoest || Type III site-specific deoxyribonuclease || Type I site-specific deoxyribonuclease || Exodeoxyribonucleases producing 5'-phosphomonoeste || Exodeoxyribonuclease V |
56091,50249
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 1 | INHERITED FROM: Polynucleotide 5'-phosphatase |
50129,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains | 1 | INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase || Thiolester hydrolases |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
82708,53098
82708 - R3H domain
53098 - Ribonuclease H-like | 0 | Direct |
47353,57756
47353 - Retrovirus capsid dimerization domain-like
57756 - Retrovirus zinc finger-like domains | 0 | Direct |
53098,53098
53098 - Ribonuclease H-like
53098 - Ribonuclease H-like | 0 | Direct |
56219,54928
56219 - DNase I-like
54928 - RNA-binding domain, RBD | 0 | Direct |
56784,54427
56784 - HAD-like
54427 - NTF2-like | 0 | Direct |
50156,52799
50156 - PDZ domain-like
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
47473,51695
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | Direct |
53474,49723
53474 - alpha/beta-Hydrolases
49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0 | Direct |
46938,52087
46938 - CRAL/TRIO N-terminal domain
52087 - CRAL/TRIO domain | 0 | Direct |
57756,50630
57756 - Retrovirus zinc finger-like domains
50630 - Acid proteases | 0 | Direct |
49562,52151
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
52151 - FabD/lysophospholipase-like | 0 | Direct |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0 | Direct |
51283,46919
51283 - dUTPase-like
46919 - N-terminal Zn binding domain of HIV integrase | 0 | Direct |
48452,56300
48452 - TPR-like
56300 - Metallo-dependent phosphatases | 0 | Direct |
54001,53098
54001 - Cysteine proteinases
53098 - Ribonuclease H-like | 0 | Direct |
52540,55144
52540 - P-loop containing nucleoside triphosphate hydrolases
55144 - LigT-like | 0 | Direct |
54637,55961
54637 - Thioesterase/thiol ester dehydrase-isomerase
55961 - Bet v1-like | 0 | Direct |
81324,52799
81324 - Voltage-gated potassium channels
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
48537,49723
48537 - Phospholipase C/P1 nuclease
49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0 | Direct |
56784,54211
56784 - HAD-like
54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
81606,81601
81606 - PP2C-like
81601 - Protein serine/threonine phosphatase 2C, C-terminal domain | 0 | Direct |
52540,53254
52540 - P-loop containing nucleoside triphosphate hydrolases
53254 - Phosphoglycerate mutase-like | 0 | Direct |
69065,54768
69065 - RNase III domain-like
54768 - dsRNA-binding domain-like | 0 | Direct |
101908,56219
101908 - Putative isomerase YbhE
56219 - DNase I-like | 0 | Direct |
52266,49818
52266 - SGNH hydrolase
49818 - Viral protein domain | 0 | Direct |
53098,54928
53098 - Ribonuclease H-like
54928 - RNA-binding domain, RBD | 0 | Direct |
49562,56024
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
56024 - Phospholipase D/nuclease | 0 | Direct |
47943,47353
47943 - Retrovirus capsid protein, N-terminal core domain
47353 - Retrovirus capsid dimerization domain-like | 0 | Direct |
55781,109604
55781 - GAF domain-like
109604 - HD-domain/PDEase-like | 0 | Direct |
56784,56784
56784 - HAD-like
56784 - HAD-like | 0 | Direct |
47233,52799
47233 - Bacterial GAP domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
51695,49562
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
53098,51283
53098 - Ribonuclease H-like
51283 - dUTPase-like | 0 | Direct |
55658,53098
55658 - L9 N-domain-like
53098 - Ribonuclease H-like | 0 | Direct |
47819,47819
47819 - HRDC-like
47819 - HRDC-like | 0 | Direct |
50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | Direct |
46919,53098
46919 - N-terminal Zn binding domain of HIV integrase
53098 - Ribonuclease H-like | 0 | Direct |
49363,56300
49363 - Purple acid phosphatase, N-terminal domain
56300 - Metallo-dependent phosphatases | 0 | Direct |
49452,52799
49452 - Starch-binding domain-like
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
51695,51695
51695 - PLC-like phosphodiesterases
51695 - PLC-like phosphodiesterases | 0 | Direct |
53098,46919
53098 - Ribonuclease H-like
46919 - N-terminal Zn binding domain of HIV integrase | 0 | Direct |
49899,48726
49899 - Concanavalin A-like lectins/glucanases
48726 - Immunoglobulin | 0 | Direct |
52058,56219
52058 - L domain-like
56219 - DNase I-like | 0 | Direct |
52799,52799
52799 - (Phosphotyrosine protein) phosphatases II
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
90188,53649
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like | 0 | Direct |
52799,56091
52799 - (Phosphotyrosine protein) phosphatases II
56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
53639,56784
53639 - AraD/HMP-PK domain-like
56784 - HAD-like | 0 | Direct |
54637,52151
54637 - Thioesterase/thiol ester dehydrase-isomerase
52151 - FabD/lysophospholipase-like | 0 | Direct |
51069,49265
51069 - Carbonic anhydrase
49265 - Fibronectin type III | 0 | Direct |
101148,51126
101148 - Plant invertase/pectin methylesterase inhibitor
51126 - Pectin lyase-like | 0 | Direct |
55267,53032
55267 - tRNA-intron endonuclease N-terminal domain-like
53032 - tRNA-intron endonuclease catalytic domain-like | 0 | Direct |
90188,90188
90188 - Somatomedin B domain
90188 - Somatomedin B domain | 0 | Direct |
52151,52151
52151 - FabD/lysophospholipase-like
52151 - FabD/lysophospholipase-like | 0 | Direct |
52172,52738
52172 - CheY-like
52738 - Methylesterase CheB, C-terminal domain | 0 | Direct |
50044,51695
50044 - SH3-domain
51695 - PLC-like phosphodiesterases | 0 | Direct |
53032,55267
53032 - tRNA-intron endonuclease catalytic domain-like
55267 - tRNA-intron endonuclease N-terminal domain-like | 0 | Direct |
50974,50974
50974 - Nitrous oxide reductase, N-terminal domain
50974 - Nitrous oxide reductase, N-terminal domain | 0 | Direct |
56672,53098
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like | 0 | Direct |
50630,56672
50630 - Acid proteases
56672 - DNA/RNA polymerases | 0 | Direct |
52266,103515
52266 - SGNH hydrolase
103515 - Autotransporter | 0 | Direct |
52821,52799
52821 - Rhodanese/Cell cycle control phosphatase
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
52087,52799
52087 - CRAL/TRIO domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
53098,50122
53098 - Ribonuclease H-like
50122 - DNA-binding domain of retroviral integrase | 0 | Direct |
53649,54060
53649 - Alkaline phosphatase-like
54060 - His-Me finger endonucleases | 0 | Direct |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0 | Direct |
69065,69065
69065 - RNase III domain-like
69065 - RNase III domain-like | 0 | Direct |
55550,52799
55550 - SH2 domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
56300,47473
56300 - Metallo-dependent phosphatases
47473 - EF-hand | 0 | Direct |
56300,56300
56300 - Metallo-dependent phosphatases
56300 - Metallo-dependent phosphatases | 0 | Direct |
56784,52540
56784 - HAD-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
47836,47943
47836 - Retroviral matrix proteins
47943 - Retrovirus capsid protein, N-terminal core domain | 0 | Direct |
53098,47819
53098 - Ribonuclease H-like
47819 - HRDC-like | 0 | Direct |
51206,51206
51206 - cAMP-binding domain-like
51206 - cAMP-binding domain-like | 0 | Direct |
50729,56024
50729 - PH domain-like
56024 - Phospholipase D/nuclease | 0 | Direct |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0 | Direct |
48403,52151
48403 - Ankyrin repeat
52151 - FabD/lysophospholipase-like | 0 | Direct |
54236,56784
54236 - Ubiquitin-like
56784 - HAD-like | 0 | Direct |
50729,52799
50729 - PH domain-like
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
49562,54236
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
54236 - Ubiquitin-like | 0 | Direct |
55154,56091
55154 - CYTH-like phosphatases
56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
109715,52799
109715 - DEK C-terminal domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
56568,47233
56568 - Non-globular alpha+beta subunits of globular proteins
47233 - Bacterial GAP domain | 0 | Direct |
55781,55781
55781 - GAF domain-like
55781 - GAF domain-like | 0 | Direct |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0.000000000000002433 | Direct |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.000000000000005366 | Direct |
52799,49562
52799 - (Phosphotyrosine protein) phosphatases II
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.000000000003954 | Direct |
54236,47031
54236 - Ubiquitin-like
47031 - Second domain of FERM | 0.00000000001061 | Direct |
64268,50729
64268 - PX domain
50729 - PH domain-like | 0.00000000001548 | Direct |
54637,54637
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0.000000000264 | Direct |
56300,55816
56300 - Metallo-dependent phosphatases
55816 - 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain | 0.0000000003387 | Direct |
47031,50729
47031 - Second domain of FERM
50729 - PH domain-like | 0.0000000009723 | Direct |
53474,53474
53474 - alpha/beta-Hydrolases
53474 - alpha/beta-Hydrolases | 0.000000001537 | Direct |
109604,81301
109604 - HD-domain/PDEase-like
81301 - Nucleotidyltransferase | 0.00000006187 | Direct |
100950,100950
100950 - NagB/RpiA/CoA transferase-like
100950 - NagB/RpiA/CoA transferase-like | 0.00000006235 | Direct |
56024,56024
56024 - Phospholipase D/nuclease
56024 - Phospholipase D/nuclease | 0.0000002495 | Direct |
47336,53474
47336 - ACP-like
53474 - alpha/beta-Hydrolases | 0.0000004283 | Direct |
81301,81271
81301 - Nucleotidyltransferase
81271 - TGS-like | 0.000002717 | Direct |
54211,54211
54211 - Ribosomal protein S5 domain 2-like
54211 - Ribosomal protein S5 domain 2-like | 0.000004075 | Direct |
54236,54236
54236 - Ubiquitin-like
54236 - Ubiquitin-like | 0.0000171 | Direct |
53335,52949
53335 - S-adenosyl-L-methionine-dependent methyltransferases
52949 - Macro domain-like | 0.00004213 | Direct |
53474,53335
53474 - alpha/beta-Hydrolases
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0.00007977 | Direct |
51735,47336
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like | 0.001882 | Inherited |
51735,51735
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains | 0.005683 | Inherited |
53774,48403
53774 - Glutaminase/Asparaginase
48403 - Ankyrin repeat | 0.006896 | Inherited |
53756,56784
53756 - UDP-Glycosyltransferase/glycogen phosphorylase
56784 - HAD-like | 0.008587 | Inherited |
52058,52058
52058 - L domain-like
52058 - L domain-like | 0.01532 | Inherited |
52151,55048
52151 - FabD/lysophospholipase-like
55048 - Probable ACP-binding domain of malonyl-CoA ACP transacylase | 0.07215 | Inherited |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.07747 | Inherited |
53098,56672
53098 - Ribonuclease H-like
56672 - DNA/RNA polymerases | 0.2839 | Inherited |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 1 | Inherited |
56091,50249
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 1 | Inherited |
50129,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEO level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
50729,56024,56024
50729 - PH domain-like
56024 - Phospholipase D/nuclease
56024 - Phospholipase D/nuclease | 0 | DIRECT |
46938,52087,52799
46938 - CRAL/TRIO N-terminal domain
52087 - CRAL/TRIO domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
55781,55781,109604
55781 - GAF domain-like
55781 - GAF domain-like
109604 - HD-domain/PDEase-like | 0 | DIRECT |
55550,55550,50044
55550 - SH2 domain
55550 - SH2 domain
50044 - SH3-domain | 0 | DIRECT |
53098,51283,46919
53098 - Ribonuclease H-like
51283 - dUTPase-like
46919 - N-terminal Zn binding domain of HIV integrase | 0 | DIRECT |
50729,47473,51695
50729 - PH domain-like
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | DIRECT |
56672,53098,51283
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like
51283 - dUTPase-like | 0 | DIRECT |
49265,49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III
49265 - Fibronectin type III | 0 | DIRECT |
47473,51695,49562
47473 - EF-hand
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
55550,55550,52799
55550 - SH2 domain
55550 - SH2 domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
53098,46919,53098
53098 - Ribonuclease H-like
46919 - N-terminal Zn binding domain of HIV integrase
53098 - Ribonuclease H-like | 0 | DIRECT |
50044,51695,49562
50044 - SH3-domain
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
57756,50630,56672
57756 - Retrovirus zinc finger-like domains
50630 - Acid proteases
56672 - DNA/RNA polymerases | 0 | DIRECT |
47836,47943,47353
47836 - Retroviral matrix proteins
47943 - Retrovirus capsid protein, N-terminal core domain
47353 - Retrovirus capsid dimerization domain-like | 0 | DIRECT |
49899,48726,49265
49899 - Concanavalin A-like lectins/glucanases
48726 - Immunoglobulin
49265 - Fibronectin type III | 0 | DIRECT |
55781,55781,55781
55781 - GAF domain-like
55781 - GAF domain-like
55781 - GAF domain-like | 0 | DIRECT |
47943,47353,57756
47943 - Retrovirus capsid protein, N-terminal core domain
47353 - Retrovirus capsid dimerization domain-like
57756 - Retrovirus zinc finger-like domains | 0 | DIRECT |
56024,56024,56024
56024 - Phospholipase D/nuclease
56024 - Phospholipase D/nuclease
56024 - Phospholipase D/nuclease | 0 | DIRECT |
56672,53098,46919
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like
46919 - N-terminal Zn binding domain of HIV integrase | 0 | DIRECT |
46919,53098,50122
46919 - N-terminal Zn binding domain of HIV integrase
53098 - Ribonuclease H-like
50122 - DNA-binding domain of retroviral integrase | 0 | DIRECT |
56672,53098,50122
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like
50122 - DNA-binding domain of retroviral integrase | 0 | DIRECT |
90188,53649,54060
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like
54060 - His-Me finger endonucleases | 0 | DIRECT |
56568,47233,52799
56568 - Non-globular alpha+beta subunits of globular proteins
47233 - Bacterial GAP domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
55267,53032,55267
55267 - tRNA-intron endonuclease N-terminal domain-like
53032 - tRNA-intron endonuclease catalytic domain-like
55267 - tRNA-intron endonuclease N-terminal domain-like | 0 | DIRECT |
56784,54211,54211
56784 - HAD-like
54211 - Ribosomal protein S5 domain 2-like
54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
69065,69065,54768
69065 - RNase III domain-like
69065 - RNase III domain-like
54768 - dsRNA-binding domain-like | 0 | DIRECT |
47353,57756,50630
47353 - Retrovirus capsid dimerization domain-like
57756 - Retrovirus zinc finger-like domains
50630 - Acid proteases | 0 | DIRECT |
81324,52799,49562
81324 - Voltage-gated potassium channels
52799 - (Phosphotyrosine protein) phosphatases II
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
53098,47819,47819
53098 - Ribonuclease H-like
47819 - HRDC-like
47819 - HRDC-like | 0 | DIRECT |
55550,50044,51695
55550 - SH2 domain
50044 - SH3-domain
51695 - PLC-like phosphodiesterases | 0 | DIRECT |
90188,90188,53649
90188 - Somatomedin B domain
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like | 0 | DIRECT |
64268,50729,56024
64268 - PX domain
50729 - PH domain-like
56024 - Phospholipase D/nuclease | 0 | DIRECT |
51283,46919,53098
51283 - dUTPase-like
46919 - N-terminal Zn binding domain of HIV integrase
53098 - Ribonuclease H-like | 0 | DIRECT |
52799,56091,50249
52799 - (Phosphotyrosine protein) phosphatases II
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
50630,56672,53098
50630 - Acid proteases
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like | 0 | DIRECT |
56672,53098,53098
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like
53098 - Ribonuclease H-like | 0 | DIRECT |
54637,54637,55961
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase
55961 - Bet v1-like | 0 | DIRECT |
49562,54236,54236
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
54236 - Ubiquitin-like
54236 - Ubiquitin-like | 0 | DIRECT |
82708,53098,54928
82708 - R3H domain
53098 - Ribonuclease H-like
54928 - RNA-binding domain, RBD | 0 | DIRECT |
53032,55267,53032
53032 - tRNA-intron endonuclease catalytic domain-like
55267 - tRNA-intron endonuclease N-terminal domain-like
53032 - tRNA-intron endonuclease catalytic domain-like | 0 | DIRECT |
48726,49265,49265
48726 - Immunoglobulin
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.000000000000001914 | DIRECT |
54236,47031,50729
54236 - Ubiquitin-like
47031 - Second domain of FERM
50729 - PH domain-like | 0.00000000001061 | DIRECT |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.00000003465 | DIRECT |
51735,47336,53474
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like
53474 - alpha/beta-Hydrolases | 0.00000006565 | DIRECT |
109604,81301,81271
109604 - HD-domain/PDEase-like
81301 - Nucleotidyltransferase
81271 - TGS-like | 0.000002717 | DIRECT |
50129,51735,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains | 0.00004126 | DIRECT |
51735,51735,47336
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like | 0.001091 | INHERITED FROM: Oleoyl-[acyl-carrier-protein] hydrolase || Thiolester hydrolases |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.01003 | INHERITED FROM: Protein-tyrosine-phosphatase || Phosphoric monoester hydrolases |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
50729,56024,56024
50729 - PH domain-like
56024 - Phospholipase D/nuclease
56024 - Phospholipase D/nuclease | 0 | Direct |
46938,52087,52799
46938 - CRAL/TRIO N-terminal domain
52087 - CRAL/TRIO domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
55781,55781,109604
55781 - GAF domain-like
55781 - GAF domain-like
109604 - HD-domain/PDEase-like | 0 | Direct |
55550,55550,50044
55550 - SH2 domain
55550 - SH2 domain
50044 - SH3-domain | 0 | Direct |
53098,51283,46919
53098 - Ribonuclease H-like
51283 - dUTPase-like
46919 - N-terminal Zn binding domain of HIV integrase | 0 | Direct |
50729,47473,51695
50729 - PH domain-like
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | Direct |
56672,53098,51283
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like
51283 - dUTPase-like | 0 | Direct |
49265,49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III
49265 - Fibronectin type III | 0 | Direct |
47473,51695,49562
47473 - EF-hand
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
55550,55550,52799
55550 - SH2 domain
55550 - SH2 domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
53098,46919,53098
53098 - Ribonuclease H-like
46919 - N-terminal Zn binding domain of HIV integrase
53098 - Ribonuclease H-like | 0 | Direct |
50044,51695,49562
50044 - SH3-domain
51695 - PLC-like phosphodiesterases
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
57756,50630,56672
57756 - Retrovirus zinc finger-like domains
50630 - Acid proteases
56672 - DNA/RNA polymerases | 0 | Direct |
47836,47943,47353
47836 - Retroviral matrix proteins
47943 - Retrovirus capsid protein, N-terminal core domain
47353 - Retrovirus capsid dimerization domain-like | 0 | Direct |
49899,48726,49265
49899 - Concanavalin A-like lectins/glucanases
48726 - Immunoglobulin
49265 - Fibronectin type III | 0 | Direct |
55781,55781,55781
55781 - GAF domain-like
55781 - GAF domain-like
55781 - GAF domain-like | 0 | Direct |
47943,47353,57756
47943 - Retrovirus capsid protein, N-terminal core domain
47353 - Retrovirus capsid dimerization domain-like
57756 - Retrovirus zinc finger-like domains | 0 | Direct |
56024,56024,56024
56024 - Phospholipase D/nuclease
56024 - Phospholipase D/nuclease
56024 - Phospholipase D/nuclease | 0 | Direct |
56672,53098,46919
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like
46919 - N-terminal Zn binding domain of HIV integrase | 0 | Direct |
46919,53098,50122
46919 - N-terminal Zn binding domain of HIV integrase
53098 - Ribonuclease H-like
50122 - DNA-binding domain of retroviral integrase | 0 | Direct |
56672,53098,50122
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like
50122 - DNA-binding domain of retroviral integrase | 0 | Direct |
90188,53649,54060
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like
54060 - His-Me finger endonucleases | 0 | Direct |
56568,47233,52799
56568 - Non-globular alpha+beta subunits of globular proteins
47233 - Bacterial GAP domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
55267,53032,55267
55267 - tRNA-intron endonuclease N-terminal domain-like
53032 - tRNA-intron endonuclease catalytic domain-like
55267 - tRNA-intron endonuclease N-terminal domain-like | 0 | Direct |
56784,54211,54211
56784 - HAD-like
54211 - Ribosomal protein S5 domain 2-like
54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
69065,69065,54768
69065 - RNase III domain-like
69065 - RNase III domain-like
54768 - dsRNA-binding domain-like | 0 | Direct |
47353,57756,50630
47353 - Retrovirus capsid dimerization domain-like
57756 - Retrovirus zinc finger-like domains
50630 - Acid proteases | 0 | Direct |
81324,52799,49562
81324 - Voltage-gated potassium channels
52799 - (Phosphotyrosine protein) phosphatases II
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
53098,47819,47819
53098 - Ribonuclease H-like
47819 - HRDC-like
47819 - HRDC-like | 0 | Direct |
55550,50044,51695
55550 - SH2 domain
50044 - SH3-domain
51695 - PLC-like phosphodiesterases | 0 | Direct |
90188,90188,53649
90188 - Somatomedin B domain
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like | 0 | Direct |
64268,50729,56024
64268 - PX domain
50729 - PH domain-like
56024 - Phospholipase D/nuclease | 0 | Direct |
51283,46919,53098
51283 - dUTPase-like
46919 - N-terminal Zn binding domain of HIV integrase
53098 - Ribonuclease H-like | 0 | Direct |
52799,56091,50249
52799 - (Phosphotyrosine protein) phosphatases II
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | Direct |
50630,56672,53098
50630 - Acid proteases
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like | 0 | Direct |
56672,53098,53098
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like
53098 - Ribonuclease H-like | 0 | Direct |
54637,54637,55961
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase
55961 - Bet v1-like | 0 | Direct |
49562,54236,54236
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
54236 - Ubiquitin-like
54236 - Ubiquitin-like | 0 | Direct |
82708,53098,54928
82708 - R3H domain
53098 - Ribonuclease H-like
54928 - RNA-binding domain, RBD | 0 | Direct |
53032,55267,53032
53032 - tRNA-intron endonuclease catalytic domain-like
55267 - tRNA-intron endonuclease N-terminal domain-like
53032 - tRNA-intron endonuclease catalytic domain-like | 0 | Direct |
48726,49265,49265
48726 - Immunoglobulin
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.000000000000001914 | Direct |
54236,47031,50729
54236 - Ubiquitin-like
47031 - Second domain of FERM
50729 - PH domain-like | 0.00000000001061 | Direct |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.00000003465 | Direct |
51735,47336,53474
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like
53474 - alpha/beta-Hydrolases | 0.00000006565 | Direct |
109604,81301,81271
109604 - HD-domain/PDEase-like
81301 - Nucleotidyltransferase
81271 - TGS-like | 0.000002717 | Direct |
50129,51735,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains | 0.00004126 | Direct |
51735,51735,47336
51735 - NAD(P)-binding Rossmann-fold domains
51735 - NAD(P)-binding Rossmann-fold domains
47336 - ACP-like | 0.001091 | Inherited |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.01003 | Inherited |
Plot distribution on phylogenetic tree for Individual Supra-domains annotated by this EC term
|
Plot tree as:
| |
Download Newick format tree:
|
(show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
|
