Bacterial dinuclear zinc exopeptidases family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: Phosphorylase/hydrolase-like [ 53162] (8)
• Superfamily: Zn-dependent exopeptidases [ 53187] (9)
• Family: Bacterial dinuclear zinc exopeptidases [ 53204] (17)

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Family statistics

	Genomes (2,905)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	11,248	84,625	24
Proteins	11,227	84,585	24

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	In linear amides	0	1.21	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.01852	--	DIRECT
Enzyme Commission (EC)	Acetylornithine deacetylase	0	2.44	--	DIRECT
Enzyme Commission (EC)	Tripeptide aminopeptidase	0	2.44	--	DIRECT
Enzyme Commission (EC)	Succinyl-diaminopimelate desuccinylase	0	2.44	--	DIRECT
Enzyme Commission (EC)	N-acetyldiaminopimelate deacetylase	0	2.44	--	DIRECT
Enzyme Commission (EC)	Cytosol nonspecific dipeptidase	0.0000000008226	2.741	--	DIRECT
Enzyme Commission (EC)	Aspartyl aminopeptidase	0.0000025	2.44	--	DIRECT
Enzyme Commission (EC)	Aminoacylase	0.00003279	2.44	--	DIRECT
Enzyme Commission (EC)	Acting on peptide bonds (peptide hydrolases)	0.000000000002234	0.5709	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on carbon-nitrogen bonds, other than peptid	0	0.8435	Moderately Informative	DIRECT
Enzyme Commission (EC)	Aminopeptidases	0	1.627	Informative	DIRECT
Enzyme Commission (EC)	Dipeptidases	0.01317	1.963	Highly Informative	INHERITED FROM: Cytosol nonspecific dipeptidase

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	basement membrane remodeling variant	0.00000000003936	1.225	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: pericellular component development variant || hermaphrodite fertility variant || reproductive system physiology variant || lethal || basement membrane remodeling variant || development variant || hermaphrodite sterile || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || fertility variant || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	pericellular component development variant	0.0000000002681	1.178	Moderately Informative	DIRECT

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.09186	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0	0.1452	--	DIRECT
Yeast Phenotype (YP)	resistance to chemicals	0	0.3202	Least Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: anatomical group || multicellular anatomical structure
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	plant cell	0	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || shoot system || plant cell
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: shoot system
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || plant organ development stage

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Tripeptide aminopeptidase	0	2.929	--	DIRECT
Enzyme Commission (EC)	Acetylornithine deacetylase	0	2.929	--	DIRECT
Enzyme Commission (EC)	Succinyl-diaminopimelate desuccinylase	0	2.929	--	DIRECT
Enzyme Commission (EC)	N-acetyldiaminopimelate deacetylase	0	2.929	--	DIRECT
Enzyme Commission (EC)	Allantoate deiminase	0.000000000000001101	2.929	--	DIRECT
Enzyme Commission (EC)	Cytosol nonspecific dipeptidase	0.0000000006755	3.23	--	DIRECT
Enzyme Commission (EC)	Aspartyl aminopeptidase	0.000002444	2.929	--	DIRECT
Enzyme Commission (EC)	N-acyl-aliphatic-L-amino acid amidohydrolase	0.000004289	2.929	--	DIRECT
Enzyme Commission (EC)	Beta-Ala-His dipeptidase	0.00002783	3.23	--	DIRECT
Enzyme Commission (EC)	N-carbamoyl-L-amino-acid hydrolase	0.0002336	2.929	--	DIRECT
Enzyme Commission (EC)	Dipeptidases	0.01335	2.452	--	INHERITED FROM: Beta-Ala-His dipeptidase || Cytosol nonspecific dipeptidase
Enzyme Commission (EC)	Hydrolases	0	0.4043	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on carbon-nitrogen bonds, other than peptide bonds	0	1.213	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on peptide bonds (peptidases)	0.0000000002061	1.004	Moderately Informative	DIRECT
Enzyme Commission (EC)	In linear amides	0	1.539	Informative	DIRECT
Enzyme Commission (EC)	Aminopeptidases	0	2.054	Highly Informative	DIRECT
Enzyme Commission (EC)	In linear amidines	1	2.084	Highly Informative	INHERITED FROM: Allantoate deiminase

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UniProtKB KeyWords (KW)

Highlighted in gray are those with FDR_all>0.001

	KW term	FDR (all)	IC level	SDKW level	Annotation (direct or inherited)
Post-translational modification	Hydrolase	0	0.4314	Least Informative	DIRECT

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