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Acting on peptide bonds (peptide hydrolases)
(show info)
Enzyme Commission (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed. To navigate hierarchical structure of EC, we display all parental EC terms to the current EC term of interest ordered by their shortest distances to the current term. Also, only direct children EC terms of the current EC term are listed.
Structural Classification of Proteins (SCOP)
SCOP classifies evolutionary-related domains into Superfamily level and Family level. Accordingly, we have generated the domain-centric EC annotations for each of the three concepts at each of the two domain levels.
Structural Domain Enzyme Commission Ontology (SDEO)
As domain-centric ontology, SDEO only refers to those EC terms which are the most informative to annotate SCOP domains.
EC annotations for SCOP domains
For details, please visit Documentation: EC annotations for SCOP domains. Therein, we provide several relevant files ( Data Availability) for the download, including an annotation file (i.e., Domain2EC.txt) and the corresponding ontology (i.e., SDEO.txt).
Supra-domain Enzyme Commission Ontology (SPEO)
As an extension, SPEO includes those EC terms which are the most informative to annotate supra-domains and individual SCOP domains at the Superfamily level.
EC annotations for Supra-domains
For details, please visit Documentation: EC annotations for Supra-domains. Therein, we provide several relevant files ( Data Availability) for the download, including a annotation file (i.e., SP2EC.txt) and an ontology (i.e., SPEO.txt). For the sake of being browsable, listed below are those supra-domains (single, dual, triple, quad).
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Root: EC Hierarchy (from IntEnz release 70)
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this EC term (SDEO level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| DEATH domain | 0 | DIRECT |
| E set domains | 0 | DIRECT |
| DNA/RNA polymerases | 0 | DIRECT |
| DNA-binding domain of retroviral integrase | 0 | DIRECT |
| Creatinase/prolidase N-terminal domain | 0 | DIRECT |
| Retrovirus capsid dimerization domain-like | 0 | DIRECT |
| TRAF domain-like | 0 | DIRECT |
| STI-like | 0 | DIRECT |
| GLA-domain | 0 | DIRECT |
| PA domain | 0 | DIRECT |
| SRCR-like | 0 | DIRECT |
| Kringle-like | 0 | DIRECT |
| Macro domain-like | 0 | DIRECT |
| Acid proteases | 0 | DIRECT |
| Clostridium neurotoxins, "coiled-coil" domain | 0 | DIRECT |
| Flavivirus capsid protein C | 0 | DIRECT |
| Coronavirus NSP8-like | 0 | DIRECT |
| X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal domain | 0 | DIRECT |
| Hedgehog/DD-peptidase | 0 | DIRECT |
| Caspase-like | 0 | DIRECT |
| RING/U-box | 0 | DIRECT |
| Cystatin/monellin | 0 | DIRECT |
| Coronavirus NSP7-like | 0 | DIRECT |
| ClpP/crotonase | 0 | DIRECT |
| DPP6 N-terminal domain-like | 0 | DIRECT |
| HybD-like | 0 | DIRECT |
| Dipeptidyl peptidase I (cathepsin C), exclusion domain | 0 | DIRECT |
| Spermadhesin, CUB domain | 0 | DIRECT |
| Positive stranded ssRNA viruses | 0 | DIRECT |
| "Winged helix" DNA-binding domain | 0 | DIRECT |
| EndoU-like | 0 | DIRECT |
| Rhomboid-like | 0 | DIRECT |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | DIRECT |
| Carboxypeptidase regulatory domain-like | 0 | DIRECT |
| PGBD-like | 0 | DIRECT |
| PUA domain-like | 0 | DIRECT |
| Cysteine proteinases | 0 | DIRECT |
| Cap-Gly domain | 0 | DIRECT |
| Metalloproteases ("zincins"), catalytic domain | 0 | DIRECT |
| Viral glycoprotein, central and dimerisation domains | 0 | DIRECT |
| Hairpin loop containing domain-like | 0 | DIRECT |
| Subtilisin-like | 0 | DIRECT |
| EGF/Laminin | 0 | DIRECT |
| LDL receptor-like module | 0 | DIRECT |
| LuxS/MPP-like metallohydrolase | 0 | DIRECT |
| Retroviral matrix proteins | 0 | DIRECT |
| Aminopeptidase/glucanase lid domain | 0 | DIRECT |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0 | DIRECT |
| Protease propeptides/inhibitors | 0 | DIRECT |
| Penicillin-binding protein associated domain | 0 | DIRECT |
| Hemopexin-like domain | 0 | DIRECT |
| Complement control module/SCR domain | 0 | DIRECT |
| alpha/beta-Hydrolases | 0 | DIRECT |
| Herpes virus serine proteinase, assemblin | 0 | DIRECT |
| PDZ domain-like | 0 | DIRECT |
| Soluble domain of poliovirus core protein 3a | 0 | DIRECT |
| Retrovirus capsid protein, N-terminal core domain | 0 | DIRECT |
| Transferrin receptor-like dimerisation domain | 0 | DIRECT |
| Peptidase/esterase 'gauge' domain | 0 | DIRECT |
| TMV-like viral coat proteins | 0 | DIRECT |
| Zn-dependent exopeptidases | 0 | DIRECT |
| LexA/Signal peptidase | 0 | DIRECT |
| TSP-1 type 1 repeat | 0 | DIRECT |
| SEA domain | 0 | DIRECT |
| Creatinase/aminopeptidase | 0 | DIRECT |
| DUSP-like | 0 | DIRECT |
| Replicase NSP9 | 0 | DIRECT |
| Retrovirus zinc finger-like domains | 0 | DIRECT |
| N-terminal Zn binding domain of HIV integrase | 0 | DIRECT |
| D-aminopeptidase, middle and C-terminal domains | 0 | DIRECT |
| SARS Nsp1-like | 0 | DIRECT |
| Blood coagulation inhibitor (disintegrin) | 0 | DIRECT |
| Coronavirus NSP10-like | 0 | DIRECT |
| NSP3A-like | 0 | DIRECT |
| Calpain large subunit, middle domain (domain III) | 0 | DIRECT |
| Trypsin-like serine proteases | 0 | DIRECT |
| Ubiquitin-like | 0.00000000000005609 | DIRECT |
| Leukotriene A4 hydrolase N-terminal domain | 0.0000000000002536 | DIRECT |
| HIT/MYND zinc finger-like | 0.000000000008193 | DIRECT |
| FnI-like domain | 0.00000000009655 | DIRECT |
| Ran binding protein zinc finger-like | 0.00000000009655 | DIRECT |
| beta-Roll | 0.000000001008 | DIRECT |
| UBA-like | 0.000000005998 | DIRECT |
| Bacterial exopeptidase dimerisation domain | 0.000000072 | DIRECT |
| Growth factor receptor domain | 0.0000008291 | DIRECT |
| Duplicated hybrid motif | 0.000001515 | DIRECT |
| EF-hand | 0.00000996 | DIRECT |
| Autotransporter | 0.0001102 | DIRECT |
| ARM repeat | 0.01346 | INHERITED FROM: Omega peptidases || Ubiquitinyl hydrolase 1 |
| Galactose-binding domain-like | 0.0161 | INHERITED FROM: Furin || Dipeptidyl-peptidases and tripeptidyl-peptidases || Xaa-Pro dipeptidyl-peptidase || Proprotein convertase 1 || Proprotein convertase 2 |
| vWA-like | 0.01625 | INHERITED FROM: Serine endopeptidases || Alternative-complement-pathway C3/C5 convertase || Classical-complement-pathway C3/C5 convertase |
| Ribosomal protein S5 domain 2-like | 0.03273 | INHERITED FROM: Endopeptidase La || Serine endopeptidases |
| Rhodanese/Cell cycle control phosphatase | 0.4896 | INHERITED FROM: Omega peptidases || Ubiquitinyl hydrolase 1 |
| Ribonuclease Rh-like | 0.8302 | INHERITED FROM: Serine endopeptidases || Pestivirus NS3 polyprotein peptidase |
| Class I glutamine amidotransferase-like | 0.9975 | INHERITED FROM: Dipeptidases || Gamma-glutamyl hydrolase || Dipeptidase E || Cyanophycinase || Peptidyl-dipeptidases |
| P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: Endopeptidase La || Flavivirin || Calicivirin || Nuclear-inclusion-a endopeptidase || Serine endopeptidases || Helper-component proteinase || Cysteine endopeptidases || Picornain 2A || Pestivirus NS3 polyprotein peptidase || Hepacivirin || Picornain 3C |
| S-adenosyl-L-methionine-dependent methyltransferases | 1 | INHERITED FROM: Flavivirin || SARS coronavirus main proteinase |
| Ribonuclease H-like | 1 | INHERITED FROM: Aspartic endopeptidases || HIV-2 retropepsin || HIV-1 retropepsin |
| beta-lactamase/transpeptidase-like | 1 | INHERITED FROM: Serine-type D-Ala-D-Ala carboxypeptidase || Serine-type carboxypeptidases || D-stereospecific aminopeptidase |
| Concanavalin A-like lectins/glucanases | 1 | INHERITED FROM: Bontoxilysin || Metalloendopeptidases |
| Pectin lyase-like | 1 | INHERITED FROM: IgA-specific serine endopeptidase |
| Metallo-dependent hydrolases | 1 | INHERITED FROM: Membrane dipeptidase || Dipeptidases |
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| DEATH domain | 0 | Direct |
| E set domains | 0 | Direct |
| DNA/RNA polymerases | 0 | Direct |
| DNA-binding domain of retroviral integrase | 0 | Direct |
| Creatinase/prolidase N-terminal domain | 0 | Direct |
| Retrovirus capsid dimerization domain-like | 0 | Direct |
| TRAF domain-like | 0 | Direct |
| STI-like | 0 | Direct |
| GLA-domain | 0 | Direct |
| PA domain | 0 | Direct |
| SRCR-like | 0 | Direct |
| Kringle-like | 0 | Direct |
| Macro domain-like | 0 | Direct |
| Acid proteases | 0 | Direct |
| Clostridium neurotoxins, "coiled-coil" domain | 0 | Direct |
| Flavivirus capsid protein C | 0 | Direct |
| Coronavirus NSP8-like | 0 | Direct |
| X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal domain | 0 | Direct |
| Hedgehog/DD-peptidase | 0 | Direct |
| Caspase-like | 0 | Direct |
| RING/U-box | 0 | Direct |
| Cystatin/monellin | 0 | Direct |
| Coronavirus NSP7-like | 0 | Direct |
| ClpP/crotonase | 0 | Direct |
| DPP6 N-terminal domain-like | 0 | Direct |
| HybD-like | 0 | Direct |
| Dipeptidyl peptidase I (cathepsin C), exclusion domain | 0 | Direct |
| Spermadhesin, CUB domain | 0 | Direct |
| Positive stranded ssRNA viruses | 0 | Direct |
| "Winged helix" DNA-binding domain | 0 | Direct |
| EndoU-like | 0 | Direct |
| Rhomboid-like | 0 | Direct |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | Direct |
| Carboxypeptidase regulatory domain-like | 0 | Direct |
| PGBD-like | 0 | Direct |
| PUA domain-like | 0 | Direct |
| Cysteine proteinases | 0 | Direct |
| Cap-Gly domain | 0 | Direct |
| Metalloproteases ("zincins"), catalytic domain | 0 | Direct |
| Viral glycoprotein, central and dimerisation domains | 0 | Direct |
| Hairpin loop containing domain-like | 0 | Direct |
| Subtilisin-like | 0 | Direct |
| EGF/Laminin | 0 | Direct |
| LDL receptor-like module | 0 | Direct |
| LuxS/MPP-like metallohydrolase | 0 | Direct |
| Retroviral matrix proteins | 0 | Direct |
| Aminopeptidase/glucanase lid domain | 0 | Direct |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0 | Direct |
| Protease propeptides/inhibitors | 0 | Direct |
| Penicillin-binding protein associated domain | 0 | Direct |
| Hemopexin-like domain | 0 | Direct |
| Complement control module/SCR domain | 0 | Direct |
| alpha/beta-Hydrolases | 0 | Direct |
| Herpes virus serine proteinase, assemblin | 0 | Direct |
| PDZ domain-like | 0 | Direct |
| Soluble domain of poliovirus core protein 3a | 0 | Direct |
| Retrovirus capsid protein, N-terminal core domain | 0 | Direct |
| Transferrin receptor-like dimerisation domain | 0 | Direct |
| Peptidase/esterase 'gauge' domain | 0 | Direct |
| TMV-like viral coat proteins | 0 | Direct |
| Zn-dependent exopeptidases | 0 | Direct |
| LexA/Signal peptidase | 0 | Direct |
| TSP-1 type 1 repeat | 0 | Direct |
| SEA domain | 0 | Direct |
| Creatinase/aminopeptidase | 0 | Direct |
| DUSP-like | 0 | Direct |
| Replicase NSP9 | 0 | Direct |
| Retrovirus zinc finger-like domains | 0 | Direct |
| N-terminal Zn binding domain of HIV integrase | 0 | Direct |
| D-aminopeptidase, middle and C-terminal domains | 0 | Direct |
| SARS Nsp1-like | 0 | Direct |
| Blood coagulation inhibitor (disintegrin) | 0 | Direct |
| Coronavirus NSP10-like | 0 | Direct |
| NSP3A-like | 0 | Direct |
| Calpain large subunit, middle domain (domain III) | 0 | Direct |
| Trypsin-like serine proteases | 0 | Direct |
| Ubiquitin-like | 0.00000000000005609 | Direct |
| Leukotriene A4 hydrolase N-terminal domain | 0.0000000000002536 | Direct |
| HIT/MYND zinc finger-like | 0.000000000008193 | Direct |
| FnI-like domain | 0.00000000009655 | Direct |
| Ran binding protein zinc finger-like | 0.00000000009655 | Direct |
| beta-Roll | 0.000000001008 | Direct |
| UBA-like | 0.000000005998 | Direct |
| Bacterial exopeptidase dimerisation domain | 0.000000072 | Direct |
| Growth factor receptor domain | 0.0000008291 | Direct |
| Duplicated hybrid motif | 0.000001515 | Direct |
| EF-hand | 0.00000996 | Direct |
| Autotransporter | 0.0001102 | Direct |
| ARM repeat | 0.01346 | Inherited |
| Galactose-binding domain-like | 0.0161 | Inherited |
| vWA-like | 0.01625 | Inherited |
| Ribosomal protein S5 domain 2-like | 0.03273 | Inherited |
| Rhodanese/Cell cycle control phosphatase | 0.4896 | Inherited |
| Ribonuclease Rh-like | 0.8302 | Inherited |
| Class I glutamine amidotransferase-like | 0.9975 | Inherited |
| P-loop containing nucleoside triphosphate hydrolases | 1 | Inherited |
| S-adenosyl-L-methionine-dependent methyltransferases | 1 | Inherited |
| Ribonuclease H-like | 1 | Inherited |
| beta-lactamase/transpeptidase-like | 1 | Inherited |
| Concanavalin A-like lectins/glucanases | 1 | Inherited |
| Pectin lyase-like | 1 | Inherited |
| Metallo-dependent hydrolases | 1 | Inherited |
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this (SDEO level: Least Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Coronavirus NSP8-like | 0 | DIRECT |
| Caspase catalytic domain | 0 | DIRECT |
| Nsp15 C-terminal domain-like | 0 | DIRECT |
| Fibronectin type II module | 0 | DIRECT |
| Class II viral fusion proteins C-terminal domain | 0 | DIRECT |
| DPP6 catalytic domain-like | 0 | DIRECT |
| Leucine aminopeptidase (Aminopeptidase A), N-terminal domain | 0 | DIRECT |
| TMV-like viral coat proteins | 0 | DIRECT |
| HtrA-like serine proteases | 0 | DIRECT |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | DIRECT |
| Subtilase propeptides/inhibitors | 0 | DIRECT |
| Serralysin-like metalloprotease, catalytic (N-terminal) domain | 0 | DIRECT |
| Ubiquitin carboxyl-terminal hydrolase, UCH | 0 | DIRECT |
| Proline iminopeptidase-like | 0 | DIRECT |
| Herpes virus serine proteinase, assemblin | 0 | DIRECT |
| Retrovirus zinc finger-like domains | 0 | DIRECT |
| VanX-like | 0 | DIRECT |
| Ubiquitin thiolesterase protein OTUB2 (Otubain-2) | 0 | DIRECT |
| Creatinase/aminopeptidase | 0 | DIRECT |
| Penta-EF-hand proteins | 0 | DIRECT |
| Spermadhesin, CUB domain | 0 | DIRECT |
| Replicase NSP9 | 0 | DIRECT |
| Type 1 signal peptidase | 0 | DIRECT |
| Retrovirus capsid protein C-terminal domain | 0 | DIRECT |
| FMDV leader protease | 0 | DIRECT |
| Serine carboxypeptidase-like | 0 | DIRECT |
| Clostridium neurotoxins, the second last domain | 0 | DIRECT |
| TNF-alpha converting enzyme, TACE, catalytic domain | 0 | DIRECT |
| Papain-like | 0 | DIRECT |
| Leucine aminopeptidase, C-terminal domain | 0 | DIRECT |
| Hemopexin-like domain | 0 | DIRECT |
| Germination protease | 0 | DIRECT |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | DIRECT |
| Cap-Gly domain | 0 | DIRECT |
| Viral proteases | 0 | DIRECT |
| RNA helicase | 0 | DIRECT |
| M48USP-like | 0 | DIRECT |
| Fibronectin type I module | 0 | DIRECT |
| Carboxypeptidase regulatory domain | 0 | DIRECT |
| Prohormone convertase 1 pro-domain | 0 | DIRECT |
| D-aminopeptidase, middle and C-terminal domains | 0 | DIRECT |
| N-terminal Zn binding domain of HIV integrase | 0 | DIRECT |
| Peptidoglycan hydrolase LytM | 0 | DIRECT |
| Prolyl oligopeptidase, N-terminal domain | 0 | DIRECT |
| Eukaryotic proteases | 0 | DIRECT |
| Tail specific protease, catalytic domain | 0 | DIRECT |
| EGF-type module | 0 | DIRECT |
| PBP5 C-terminal domain-like | 0 | DIRECT |
| Clostridium neurotoxins, C-terminal domain | 0 | DIRECT |
| Immunodeficiency virus matrix proteins | 0 | DIRECT |
| MPP-like | 0 | DIRECT |
| MMP N-terminal domain | 0 | DIRECT |
| Matrix metalloproteases, catalytic domain | 0 | DIRECT |
| Rhomboid-like | 0 | DIRECT |
| Prokaryotic proteases | 0 | DIRECT |
| Adenain-like | 0 | DIRECT |
| Nsp15 N-terminal domain-like | 0 | DIRECT |
| Reprolysin-like | 0 | DIRECT |
| Calpain large subunit, catalytic domain (domain II) | 0 | DIRECT |
| Thermolysin-like | 0 | DIRECT |
| Clostridium neurotoxins, "coiled-coil" domain | 0 | DIRECT |
| Staphopain B, prodomain | 0 | DIRECT |
| RNA-dependent RNA-polymerase | 0 | DIRECT |
| Astacin | 0 | DIRECT |
| Picornaviridae-like VP (VP1, VP2, VP3 and VP4) | 0 | DIRECT |
| SARS Nsp1-like | 0 | DIRECT |
| Flavivirus capsid protein C | 0 | DIRECT |
| LexA repressor, N-terminal DNA-binding domain | 0 | DIRECT |
| X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal domain | 0 | DIRECT |
| Viral glycoprotein, central and dimerisation domains | 0 | DIRECT |
| PepX C-terminal domain-like | 0 | DIRECT |
| Prolyl oligopeptidase, C-terminal domain | 0 | DIRECT |
| Gingipain R (RgpB), N-terminal domain | 0 | DIRECT |
| Soluble domain of poliovirus core protein 3a | 0 | DIRECT |
| Renal dipeptidase | 0 | DIRECT |
| DPP6 N-terminal domain-like | 0 | DIRECT |
| Clp protease, ClpP subunit | 0 | DIRECT |
| Proprotein convertase P-domain | 0 | DIRECT |
| TSP-1 type 1 repeat | 0 | DIRECT |
| Fungal zinc peptidase | 0 | DIRECT |
| Dipeptidyl peptidase I (cathepsin C), exclusion domain | 0 | DIRECT |
| LexA-related | 0 | DIRECT |
| Calpain large subunit, middle domain (domain III) | 0 | DIRECT |
| NSP3A-like | 0 | DIRECT |
| GLA-domain | 0 | DIRECT |
| Pancreatic carboxypeptidases | 0 | DIRECT |
| Scavenger receptor cysteine-rich (SRCR) domain | 0 | DIRECT |
| LON domain-like | 0 | DIRECT |
| Dac-like | 0 | DIRECT |
| Subtilases | 0 | DIRECT |
| Retroviral protease (retropepsin) | 0 | DIRECT |
| Coronavirus NSP7-like | 0 | DIRECT |
| ATP-dependent protease Lon (La), catalytic domain | 0 | DIRECT |
| Pepsin-like | 0 | DIRECT |
| DUSP, domain in ubiquitin-specific proteases | 0 | DIRECT |
| Methionine aminopeptidase, insert domain | 0 | DIRECT |
| Blood coagulation inhibitor (disintegrin) | 0 | DIRECT |
| Caliciviridae-like VP | 0 | DIRECT |
| Aspartyl dipeptidase PepE | 0 | DIRECT |
| Creatinase/prolidase N-terminal domain | 0 | DIRECT |
| Caspase recruitment domain, CARD | 0 | DIRECT |
| Pancreatic carboxypeptidase, activation domain | 0 | DIRECT |
| Gamma-glutamyltranspeptidase-like | 0 | DIRECT |
| Kringle modules | 0 | DIRECT |
| FolH catalytic domain-like | 0 | DIRECT |
| LDL receptor-like module | 0 | DIRECT |
| Coronavirus NSP10-like | 0 | DIRECT |
| Neurolysin-like | 0 | DIRECT |
| Acylamino-acid-releasing enzyme, C-terminal donain | 0 | DIRECT |
| Neutral endopeptidase (neprilysin) | 0 | DIRECT |
| Serine-carboxyl proteinase, SCP | 0 | DIRECT |
| Zf-UBP | 0 | DIRECT |
| Proteasome subunits | 0 | DIRECT |
| Clostridium neurotoxins, catalytic domain | 0 | DIRECT |
| Transferrin receptor-like dimerisation domain | 0 | DIRECT |
| Virulence factor P.69 pertactin | 0 | DIRECT |
| Retrovirus capsid protein, N-terminal core domain | 0 | DIRECT |
| Integrin A (or I) domain | 0 | DIRECT |
| PA domain | 0 | DIRECT |
| Aminopeptidase/glucanase lid domain | 0 | DIRECT |
| Viral cysteine protease of trypsin fold | 0 | DIRECT |
| Leishmanolysin | 0 | DIRECT |
| DNA-binding domain of retroviral integrase | 0 | DIRECT |
| mRNA cap methylase | 0 | DIRECT |
| PepX catalytic domain-like | 0 | DIRECT |
| Complement control module/SCR domain | 0 | DIRECT |
| Nodaviridae-like VP | 0 | DIRECT |
| MATH domain | 0 | DIRECT |
| Reverse transcriptase | 0.000000000000003089 | DIRECT |
| Macro domain | 0.0000000000001809 | DIRECT |
| Leukotriene A4 hydrolase catalytic domain | 0.0000000000006633 | DIRECT |
| Bacterial dinuclear zinc exopeptidases | 0.000000000002234 | DIRECT |
| Ran binding protein zinc finger-like | 0.0000000001094 | DIRECT |
| Leukotriene A4 hydrolase N-terminal domain | 0.0000000001927 | DIRECT |
| MYND zinc finger | 0.0000000009818 | DIRECT |
| Retroviral integrase, catalytic domain | 0.0000000009996 | DIRECT |
| Serralysin-like metalloprotease, C-terminal domain | 0.000000001261 | DIRECT |
| Ubiquitin-related | 0.0000003546 | DIRECT |
| Bacterial exopeptidase dimerisation domain | 0.0000005562 | DIRECT |
| UBA domain | 0.000001027 | DIRECT |
| MAM domain | 0.0001296 | DIRECT |
| Growth factor receptor domain | 0.0007136 | DIRECT |
| (Glycosyl)asparaginase | 0.007451 | INHERITED FROM: Beta-aspartyl-peptidase || Omega peptidases |
| beta-Lactamase/D-ala carboxypeptidase | 0.3536 | INHERITED FROM: Serine-type D-Ala-D-Ala carboxypeptidase || Serine-type carboxypeptidases || D-stereospecific aminopeptidase || Aminopeptidases |
| Ribonuclease Rh-like | 0.8136 | INHERITED FROM: Serine endopeptidases || Pestivirus NS3 polyprotein peptidase |
| Ribonuclease H | 1 | INHERITED FROM: Aspartic endopeptidases || HIV-2 retropepsin || HIV-1 retropepsin |
| Class I glutamine amidotransferases (GAT) | 1 | INHERITED FROM: Gamma-glutamyl hydrolase |
| Extended AAA-ATPase domain | 1 | INHERITED FROM: Endopeptidase La || Serine endopeptidases |
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Coronavirus NSP8-like | 0 | Direct |
| Caspase catalytic domain | 0 | Direct |
| Nsp15 C-terminal domain-like | 0 | Direct |
| Fibronectin type II module | 0 | Direct |
| Class II viral fusion proteins C-terminal domain | 0 | Direct |
| DPP6 catalytic domain-like | 0 | Direct |
| Leucine aminopeptidase (Aminopeptidase A), N-terminal domain | 0 | Direct |
| TMV-like viral coat proteins | 0 | Direct |
| HtrA-like serine proteases | 0 | Direct |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | Direct |
| Subtilase propeptides/inhibitors | 0 | Direct |
| Serralysin-like metalloprotease, catalytic (N-terminal) domain | 0 | Direct |
| Ubiquitin carboxyl-terminal hydrolase, UCH | 0 | Direct |
| Proline iminopeptidase-like | 0 | Direct |
| Herpes virus serine proteinase, assemblin | 0 | Direct |
| Retrovirus zinc finger-like domains | 0 | Direct |
| VanX-like | 0 | Direct |
| Ubiquitin thiolesterase protein OTUB2 (Otubain-2) | 0 | Direct |
| Creatinase/aminopeptidase | 0 | Direct |
| Penta-EF-hand proteins | 0 | Direct |
| Spermadhesin, CUB domain | 0 | Direct |
| Replicase NSP9 | 0 | Direct |
| Type 1 signal peptidase | 0 | Direct |
| Retrovirus capsid protein C-terminal domain | 0 | Direct |
| FMDV leader protease | 0 | Direct |
| Serine carboxypeptidase-like | 0 | Direct |
| Clostridium neurotoxins, the second last domain | 0 | Direct |
| TNF-alpha converting enzyme, TACE, catalytic domain | 0 | Direct |
| Papain-like | 0 | Direct |
| Leucine aminopeptidase, C-terminal domain | 0 | Direct |
| Hemopexin-like domain | 0 | Direct |
| Germination protease | 0 | Direct |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | Direct |
| Cap-Gly domain | 0 | Direct |
| Viral proteases | 0 | Direct |
| RNA helicase | 0 | Direct |
| M48USP-like | 0 | Direct |
| Fibronectin type I module | 0 | Direct |
| Carboxypeptidase regulatory domain | 0 | Direct |
| Prohormone convertase 1 pro-domain | 0 | Direct |
| D-aminopeptidase, middle and C-terminal domains | 0 | Direct |
| N-terminal Zn binding domain of HIV integrase | 0 | Direct |
| Peptidoglycan hydrolase LytM | 0 | Direct |
| Prolyl oligopeptidase, N-terminal domain | 0 | Direct |
| Eukaryotic proteases | 0 | Direct |
| Tail specific protease, catalytic domain | 0 | Direct |
| EGF-type module | 0 | Direct |
| PBP5 C-terminal domain-like | 0 | Direct |
| Clostridium neurotoxins, C-terminal domain | 0 | Direct |
| Immunodeficiency virus matrix proteins | 0 | Direct |
| MPP-like | 0 | Direct |
| MMP N-terminal domain | 0 | Direct |
| Matrix metalloproteases, catalytic domain | 0 | Direct |
| Rhomboid-like | 0 | Direct |
| Prokaryotic proteases | 0 | Direct |
| Adenain-like | 0 | Direct |
| Nsp15 N-terminal domain-like | 0 | Direct |
| Reprolysin-like | 0 | Direct |
| Calpain large subunit, catalytic domain (domain II) | 0 | Direct |
| Thermolysin-like | 0 | Direct |
| Clostridium neurotoxins, "coiled-coil" domain | 0 | Direct |
| Staphopain B, prodomain | 0 | Direct |
| RNA-dependent RNA-polymerase | 0 | Direct |
| Astacin | 0 | Direct |
| Picornaviridae-like VP (VP1, VP2, VP3 and VP4) | 0 | Direct |
| SARS Nsp1-like | 0 | Direct |
| Flavivirus capsid protein C | 0 | Direct |
| LexA repressor, N-terminal DNA-binding domain | 0 | Direct |
| X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal domain | 0 | Direct |
| Viral glycoprotein, central and dimerisation domains | 0 | Direct |
| PepX C-terminal domain-like | 0 | Direct |
| Prolyl oligopeptidase, C-terminal domain | 0 | Direct |
| Gingipain R (RgpB), N-terminal domain | 0 | Direct |
| Soluble domain of poliovirus core protein 3a | 0 | Direct |
| Renal dipeptidase | 0 | Direct |
| DPP6 N-terminal domain-like | 0 | Direct |
| Clp protease, ClpP subunit | 0 | Direct |
| Proprotein convertase P-domain | 0 | Direct |
| TSP-1 type 1 repeat | 0 | Direct |
| Fungal zinc peptidase | 0 | Direct |
| Dipeptidyl peptidase I (cathepsin C), exclusion domain | 0 | Direct |
| LexA-related | 0 | Direct |
| Calpain large subunit, middle domain (domain III) | 0 | Direct |
| NSP3A-like | 0 | Direct |
| GLA-domain | 0 | Direct |
| Pancreatic carboxypeptidases | 0 | Direct |
| Scavenger receptor cysteine-rich (SRCR) domain | 0 | Direct |
| LON domain-like | 0 | Direct |
| Dac-like | 0 | Direct |
| Subtilases | 0 | Direct |
| Retroviral protease (retropepsin) | 0 | Direct |
| Coronavirus NSP7-like | 0 | Direct |
| ATP-dependent protease Lon (La), catalytic domain | 0 | Direct |
| Pepsin-like | 0 | Direct |
| DUSP, domain in ubiquitin-specific proteases | 0 | Direct |
| Methionine aminopeptidase, insert domain | 0 | Direct |
| Blood coagulation inhibitor (disintegrin) | 0 | Direct |
| Caliciviridae-like VP | 0 | Direct |
| Aspartyl dipeptidase PepE | 0 | Direct |
| Creatinase/prolidase N-terminal domain | 0 | Direct |
| Caspase recruitment domain, CARD | 0 | Direct |
| Pancreatic carboxypeptidase, activation domain | 0 | Direct |
| Gamma-glutamyltranspeptidase-like | 0 | Direct |
| Kringle modules | 0 | Direct |
| FolH catalytic domain-like | 0 | Direct |
| LDL receptor-like module | 0 | Direct |
| Coronavirus NSP10-like | 0 | Direct |
| Neurolysin-like | 0 | Direct |
| Acylamino-acid-releasing enzyme, C-terminal donain | 0 | Direct |
| Neutral endopeptidase (neprilysin) | 0 | Direct |
| Serine-carboxyl proteinase, SCP | 0 | Direct |
| Zf-UBP | 0 | Direct |
| Proteasome subunits | 0 | Direct |
| Clostridium neurotoxins, catalytic domain | 0 | Direct |
| Transferrin receptor-like dimerisation domain | 0 | Direct |
| Virulence factor P.69 pertactin | 0 | Direct |
| Retrovirus capsid protein, N-terminal core domain | 0 | Direct |
| Integrin A (or I) domain | 0 | Direct |
| PA domain | 0 | Direct |
| Aminopeptidase/glucanase lid domain | 0 | Direct |
| Viral cysteine protease of trypsin fold | 0 | Direct |
| Leishmanolysin | 0 | Direct |
| DNA-binding domain of retroviral integrase | 0 | Direct |
| mRNA cap methylase | 0 | Direct |
| PepX catalytic domain-like | 0 | Direct |
| Complement control module/SCR domain | 0 | Direct |
| Nodaviridae-like VP | 0 | Direct |
| MATH domain | 0 | Direct |
| Reverse transcriptase | 0.000000000000003089 | Direct |
| Macro domain | 0.0000000000001809 | Direct |
| Leukotriene A4 hydrolase catalytic domain | 0.0000000000006633 | Direct |
| Bacterial dinuclear zinc exopeptidases | 0.000000000002234 | Direct |
| Ran binding protein zinc finger-like | 0.0000000001094 | Direct |
| Leukotriene A4 hydrolase N-terminal domain | 0.0000000001927 | Direct |
| MYND zinc finger | 0.0000000009818 | Direct |
| Retroviral integrase, catalytic domain | 0.0000000009996 | Direct |
| Serralysin-like metalloprotease, C-terminal domain | 0.000000001261 | Direct |
| Ubiquitin-related | 0.0000003546 | Direct |
| Bacterial exopeptidase dimerisation domain | 0.0000005562 | Direct |
| UBA domain | 0.000001027 | Direct |
| MAM domain | 0.0001296 | Direct |
| Growth factor receptor domain | 0.0007136 | Direct |
| (Glycosyl)asparaginase | 0.007451 | Inherited |
| beta-Lactamase/D-ala carboxypeptidase | 0.3536 | Inherited |
| Ribonuclease Rh-like | 0.8136 | Inherited |
| Ribonuclease H | 1 | Inherited |
| Class I glutamine amidotransferases (GAT) | 1 | Inherited |
| Extended AAA-ATPase domain | 1 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this EC term
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A presence/absence matrix is generated using protein domains and supradomains
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heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
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Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this EC term (SPEO level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Hedgehog/DD-peptidase | 0 | DIRECT |
| RING/U-box | 0 | DIRECT |
| N-terminal Zn binding domain of HIV integrase | 0 | DIRECT |
| Zn-dependent exopeptidases | 0 | DIRECT |
| Kringle-like | 0 | DIRECT |
| Coronavirus NSP8-like | 0 | DIRECT |
| Rhomboid-like | 0 | DIRECT |
| Sec-C motif | 0 | DIRECT |
| Acid proteases | 0 | DIRECT |
| Cap-Gly domain | 0 | DIRECT |
| TSP-1 type 1 repeat | 0 | DIRECT |
| Retroviral matrix proteins | 0 | DIRECT |
| Soluble domain of poliovirus core protein 3a | 0 | DIRECT |
| TRAF domain-like | 0 | DIRECT |
| Retrovirus zinc finger-like domains | 0 | DIRECT |
| PGBD-like | 0 | DIRECT |
| Protease propeptides/inhibitors | 0 | DIRECT |
| Calpain large subunit, middle domain (domain III) | 0 | DIRECT |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | DIRECT |
| OMPT-like | 0 | DIRECT |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0 | DIRECT |
| Cystatin/monellin | 0 | DIRECT |
| LexA/Signal peptidase | 0 | DIRECT |
| LDL receptor-like module | 0 | DIRECT |
| PUA domain-like | 0 | DIRECT |
| EGF/Laminin | 0 | DIRECT |
| Trypsin-like serine proteases | 0 | DIRECT |
| Positive stranded ssRNA viruses | 0 | DIRECT |
| Metalloproteases ("zincins"), catalytic domain | 0 | DIRECT |
| HybD-like | 0 | DIRECT |
| Replicase NSP9 | 0 | DIRECT |
| E set domains | 0 | DIRECT |
| DNA-binding domain of retroviral integrase | 0 | DIRECT |
| DPP6 N-terminal domain-like | 0 | DIRECT |
| Subtilisin-like | 0 | DIRECT |
| Flavivirus capsid protein C | 0 | DIRECT |
| Dipeptidyl peptidase I (cathepsin C), exclusion domain | 0 | DIRECT |
| Spermadhesin, CUB domain | 0 | DIRECT |
| Creatinase/prolidase N-terminal domain | 0 | DIRECT |
| alpha/beta-Hydrolases | 0 | DIRECT |
| GLA-domain | 0 | DIRECT |
| Transferrin receptor-like dimerisation domain | 0 | DIRECT |
| PDZ domain-like | 0 | DIRECT |
| NSP3A-like | 0 | DIRECT |
| Hairpin loop containing domain-like | 0 | DIRECT |
| STI-like | 0 | DIRECT |
| PA domain | 0 | DIRECT |
| Caspase-like | 0 | DIRECT |
| LuxS/MPP-like metallohydrolase | 0 | DIRECT |
| Blood coagulation inhibitor (disintegrin) | 0 | DIRECT |
| EndoU-like | 0 | DIRECT |
| ClpP/crotonase | 0 | DIRECT |
| Penicillin-binding protein associated domain | 0 | DIRECT |
| Retrovirus capsid protein, N-terminal core domain | 0 | DIRECT |
| LD-carboxypeptidase A C-terminal domain-like | 0 | DIRECT |
| DUSP-like | 0 | DIRECT |
| X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal domain | 0 | DIRECT |
| Collagen-binding domain | 0 | DIRECT |
| D-aminopeptidase, middle and C-terminal domains | 0 | DIRECT |
| Aminopeptidase/glucanase lid domain | 0 | DIRECT |
| TMV-like viral coat proteins | 0 | DIRECT |
| Macro domain-like | 0 | DIRECT |
| Viral leader polypeptide zinc finger | 0 | DIRECT |
| SARS Nsp1-like | 0 | DIRECT |
| SEA domain | 0 | DIRECT |
| Herpes virus serine proteinase, assemblin | 0 | DIRECT |
| Coronavirus NSP10-like | 0 | DIRECT |
| Hemopexin-like domain | 0 | DIRECT |
| Clostridium neurotoxins, "coiled-coil" domain | 0 | DIRECT |
| DEATH domain | 0 | DIRECT |
| Retrovirus capsid dimerization domain-like | 0 | DIRECT |
| Complement control module/SCR domain | 0 | DIRECT |
| Coronavirus NSP7-like | 0 | DIRECT |
| Kazal-type serine protease inhibitors | 0 | DIRECT |
| "Winged helix" DNA-binding domain | 0 | DIRECT |
| DNA/RNA polymerases | 0 | DIRECT |
| Cysteine proteinases | 0 | DIRECT |
| Peptidase/esterase 'gauge' domain | 0 | DIRECT |
| Viral glycoprotein, central and dimerisation domains | 0 | DIRECT |
| Creatinase/aminopeptidase | 0 | DIRECT |
| Carboxypeptidase regulatory domain-like | 0 | DIRECT |
| Ubiquitin-like | 0.00000000000004064 | DIRECT |
| SRCR-like | 0.000000000000069 | DIRECT |
| Leukotriene A4 hydrolase N-terminal domain | 0.0000000000001834 | DIRECT |
| HIT/MYND zinc finger-like | 0.00000000000618 | DIRECT |
| UBA-like | 0.00000000001095 | DIRECT |
| Ran binding protein zinc finger-like | 0.0000000000739 | DIRECT |
| FnI-like domain | 0.0000000000739 | DIRECT |
| beta-Roll | 0.0000000007822 | DIRECT |
| Bacterial exopeptidase dimerisation domain | 0.00000005298 | DIRECT |
| Growth factor receptor domain | 0.0000006568 | DIRECT |
| Duplicated hybrid motif | 0.000001214 | DIRECT |
| EF-hand | 0.000007965 | DIRECT |
| Autotransporter | 0.00009164 | DIRECT |
| PKD domain | 0.0001335 | DIRECT |
| HSP20-like chaperones | 0.001032 | INHERITED FROM: Omega peptidases || Ubiquitinyl hydrolase 1 |
| ARM repeat | 0.01162 | INHERITED FROM: Aminopeptidase B || Omega peptidases || Ubiquitinyl hydrolase 1 |
| Galactose-binding domain-like | 0.01367 | INHERITED FROM: Furin || Dipeptidyl-peptidases and tripeptidyl-peptidases || Xaa-Pro dipeptidyl-peptidase || Proprotein convertase 1 || Proprotein convertase 2 |
| vWA-like | 0.01409 | INHERITED FROM: Serine endopeptidases || Alternative-complement-pathway C3/C5 convertase || Classical-complement-pathway C3/C5 convertase |
| Ribosomal protein S5 domain 2-like | 0.02763 | INHERITED FROM: Endopeptidase La || Serine endopeptidases |
| Rhodanese/Cell cycle control phosphatase | 0.4541 | INHERITED FROM: Omega peptidases || Ubiquitinyl hydrolase 1 |
| Ribonuclease Rh-like | 0.7796 | INHERITED FROM: Serine endopeptidases || Pestivirus NS3 polyprotein peptidase |
| Class I glutamine amidotransferase-like | 0.9381 | INHERITED FROM: Dipeptidases || Gamma-glutamyl hydrolase || Dipeptidase E || Muramoyltetrapeptide carboxypeptidase || Cyanophycinase || Peptidyl-dipeptidases |
| Ribonuclease H-like | 1 | INHERITED FROM: Aspartic endopeptidases || HIV-2 retropepsin || HIV-1 retropepsin |
| Metallo-dependent hydrolases | 1 | INHERITED FROM: Membrane dipeptidase || Dipeptidases |
| beta-lactamase/transpeptidase-like | 1 | INHERITED FROM: Serine-type D-Ala-D-Ala carboxypeptidase || Serine-type carboxypeptidases || D-stereospecific aminopeptidase |
| S-adenosyl-L-methionine-dependent methyltransferases | 1 | INHERITED FROM: Flavivirin || SARS coronavirus main proteinase || Endothelin-converting enzyme 1 |
| Pectin lyase-like | 1 | INHERITED FROM: IgA-specific serine endopeptidase || Ubiquitinyl hydrolase 1 |
| P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: Endopeptidase La || Flavivirin || Calicivirin || Nuclear-inclusion-a endopeptidase || Serine endopeptidases || Helper-component proteinase || Cysteine endopeptidases || Picornain 2A || Pestivirus NS3 polyprotein peptidase || Hepacivirin || Picornain 3C |
| Concanavalin A-like lectins/glucanases | 1 | INHERITED FROM: Bontoxilysin || Meprin B || Metalloendopeptidases || Enteropeptidase || Meprin A |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Hedgehog/DD-peptidase | 0 | Direct |
| RING/U-box | 0 | Direct |
| N-terminal Zn binding domain of HIV integrase | 0 | Direct |
| Zn-dependent exopeptidases | 0 | Direct |
| Kringle-like | 0 | Direct |
| Coronavirus NSP8-like | 0 | Direct |
| Rhomboid-like | 0 | Direct |
| Sec-C motif | 0 | Direct |
| Acid proteases | 0 | Direct |
| Cap-Gly domain | 0 | Direct |
| TSP-1 type 1 repeat | 0 | Direct |
| Retroviral matrix proteins | 0 | Direct |
| Soluble domain of poliovirus core protein 3a | 0 | Direct |
| TRAF domain-like | 0 | Direct |
| Retrovirus zinc finger-like domains | 0 | Direct |
| PGBD-like | 0 | Direct |
| Protease propeptides/inhibitors | 0 | Direct |
| Calpain large subunit, middle domain (domain III) | 0 | Direct |
| Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) | 0 | Direct |
| OMPT-like | 0 | Direct |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0 | Direct |
| Cystatin/monellin | 0 | Direct |
| LexA/Signal peptidase | 0 | Direct |
| LDL receptor-like module | 0 | Direct |
| PUA domain-like | 0 | Direct |
| EGF/Laminin | 0 | Direct |
| Trypsin-like serine proteases | 0 | Direct |
| Positive stranded ssRNA viruses | 0 | Direct |
| Metalloproteases ("zincins"), catalytic domain | 0 | Direct |
| HybD-like | 0 | Direct |
| Replicase NSP9 | 0 | Direct |
| E set domains | 0 | Direct |
| DNA-binding domain of retroviral integrase | 0 | Direct |
| DPP6 N-terminal domain-like | 0 | Direct |
| Subtilisin-like | 0 | Direct |
| Flavivirus capsid protein C | 0 | Direct |
| Dipeptidyl peptidase I (cathepsin C), exclusion domain | 0 | Direct |
| Spermadhesin, CUB domain | 0 | Direct |
| Creatinase/prolidase N-terminal domain | 0 | Direct |
| alpha/beta-Hydrolases | 0 | Direct |
| GLA-domain | 0 | Direct |
| Transferrin receptor-like dimerisation domain | 0 | Direct |
| PDZ domain-like | 0 | Direct |
| NSP3A-like | 0 | Direct |
| Hairpin loop containing domain-like | 0 | Direct |
| STI-like | 0 | Direct |
| PA domain | 0 | Direct |
| Caspase-like | 0 | Direct |
| LuxS/MPP-like metallohydrolase | 0 | Direct |
| Blood coagulation inhibitor (disintegrin) | 0 | Direct |
| EndoU-like | 0 | Direct |
| ClpP/crotonase | 0 | Direct |
| Penicillin-binding protein associated domain | 0 | Direct |
| Retrovirus capsid protein, N-terminal core domain | 0 | Direct |
| LD-carboxypeptidase A C-terminal domain-like | 0 | Direct |
| DUSP-like | 0 | Direct |
| X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal domain | 0 | Direct |
| Collagen-binding domain | 0 | Direct |
| D-aminopeptidase, middle and C-terminal domains | 0 | Direct |
| Aminopeptidase/glucanase lid domain | 0 | Direct |
| TMV-like viral coat proteins | 0 | Direct |
| Macro domain-like | 0 | Direct |
| Viral leader polypeptide zinc finger | 0 | Direct |
| SARS Nsp1-like | 0 | Direct |
| SEA domain | 0 | Direct |
| Herpes virus serine proteinase, assemblin | 0 | Direct |
| Coronavirus NSP10-like | 0 | Direct |
| Hemopexin-like domain | 0 | Direct |
| Clostridium neurotoxins, "coiled-coil" domain | 0 | Direct |
| DEATH domain | 0 | Direct |
| Retrovirus capsid dimerization domain-like | 0 | Direct |
| Complement control module/SCR domain | 0 | Direct |
| Coronavirus NSP7-like | 0 | Direct |
| Kazal-type serine protease inhibitors | 0 | Direct |
| "Winged helix" DNA-binding domain | 0 | Direct |
| DNA/RNA polymerases | 0 | Direct |
| Cysteine proteinases | 0 | Direct |
| Peptidase/esterase 'gauge' domain | 0 | Direct |
| Viral glycoprotein, central and dimerisation domains | 0 | Direct |
| Creatinase/aminopeptidase | 0 | Direct |
| Carboxypeptidase regulatory domain-like | 0 | Direct |
| Ubiquitin-like | 0.00000000000004064 | Direct |
| SRCR-like | 0.000000000000069 | Direct |
| Leukotriene A4 hydrolase N-terminal domain | 0.0000000000001834 | Direct |
| HIT/MYND zinc finger-like | 0.00000000000618 | Direct |
| UBA-like | 0.00000000001095 | Direct |
| Ran binding protein zinc finger-like | 0.0000000000739 | Direct |
| FnI-like domain | 0.0000000000739 | Direct |
| beta-Roll | 0.0000000007822 | Direct |
| Bacterial exopeptidase dimerisation domain | 0.00000005298 | Direct |
| Growth factor receptor domain | 0.0000006568 | Direct |
| Duplicated hybrid motif | 0.000001214 | Direct |
| EF-hand | 0.000007965 | Direct |
| Autotransporter | 0.00009164 | Direct |
| PKD domain | 0.0001335 | Direct |
| HSP20-like chaperones | 0.001032 | Inherited |
| ARM repeat | 0.01162 | Inherited |
| Galactose-binding domain-like | 0.01367 | Inherited |
| vWA-like | 0.01409 | Inherited |
| Ribosomal protein S5 domain 2-like | 0.02763 | Inherited |
| Rhodanese/Cell cycle control phosphatase | 0.4541 | Inherited |
| Ribonuclease Rh-like | 0.7796 | Inherited |
| Class I glutamine amidotransferase-like | 0.9381 | Inherited |
| Ribonuclease H-like | 1 | Inherited |
| Metallo-dependent hydrolases | 1 | Inherited |
| beta-lactamase/transpeptidase-like | 1 | Inherited |
| S-adenosyl-L-methionine-dependent methyltransferases | 1 | Inherited |
| Pectin lyase-like | 1 | Inherited |
| P-loop containing nucleoside triphosphate hydrolases | 1 | Inherited |
| Concanavalin A-like lectins/glucanases | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEO level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57196,50494
57196 - EGF/Laminin
50494 - Trypsin-like serine proteases | 0 | DIRECT |
47353,57756
47353 - Retrovirus capsid dimerization domain-like
57756 - Retrovirus zinc finger-like domains | 0 | DIRECT |
49464,53187
49464 - Carboxypeptidase regulatory domain-like
53187 - Zn-dependent exopeptidases | 0 | DIRECT |
57184,50494
57184 - Growth factor receptor domain
50494 - Trypsin-like serine proteases | 0 | DIRECT |
56983,81296
56983 - Viral glycoprotein, central and dimerisation domains
81296 - E set domains | 0 | DIRECT |
57756,50630
57756 - Retrovirus zinc finger-like domains
50630 - Acid proteases | 0 | DIRECT |
57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | DIRECT |
57630,57440
57630 - GLA-domain
57440 - Kringle-like | 0 | DIRECT |
159936,52949
159936 - NSP3A-like
52949 - Macro domain-like | 0 | DIRECT |
56601,50886
56601 - beta-lactamase/transpeptidase-like
50886 - D-aminopeptidase, middle and C-terminal domains | 0 | DIRECT |
54001,49758
54001 - Cysteine proteinases
49758 - Calpain large subunit, middle domain (domain III) | 0 | DIRECT |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0 | DIRECT |
57630,57184
57630 - GLA-domain
57184 - Growth factor receptor domain | 0 | DIRECT |
54001,143791
54001 - Cysteine proteinases
143791 - DUSP-like | 0 | DIRECT |
47473,144091
47473 - EF-hand
144091 - Rhomboid-like | 0 | DIRECT |
54001,88633
54001 - Cysteine proteinases
88633 - Positive stranded ssRNA viruses | 0 | DIRECT |
53092,55920
53092 - Creatinase/prolidase N-terminal domain
55920 - Creatinase/aminopeptidase | 0 | DIRECT |
57424,49854
57424 - LDL receptor-like module
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
48371,54001
48371 - ARM repeat
54001 - Cysteine proteinases | 0 | DIRECT |
50494,50156
50494 - Trypsin-like serine proteases
50156 - PDZ domain-like | 0 | DIRECT |
50494,56672
50494 - Trypsin-like serine proteases
56672 - DNA/RNA polymerases | 0 | DIRECT |
101821,53187
101821 - Aminopeptidase/glucanase lid domain
53187 - Zn-dependent exopeptidases | 0 | DIRECT |
82171,53474
82171 - DPP6 N-terminal domain-like
53474 - alpha/beta-Hydrolases | 0 | DIRECT |
54897,52743
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like | 0 | DIRECT |
88633,88633
88633 - Positive stranded ssRNA viruses
88633 - Positive stranded ssRNA viruses | 0 | DIRECT |
47986,52129
47986 - DEATH domain
52129 - Caspase-like | 0 | DIRECT |
54897,53187
54897 - Protease propeptides/inhibitors
53187 - Zn-dependent exopeptidases | 0 | DIRECT |
103642,55920
103642 - Sec-C motif
55920 - Creatinase/aminopeptidase | 0 | DIRECT |
57603,57440
57603 - FnI-like domain
57440 - Kringle-like | 0 | DIRECT |
52949,53187
52949 - Macro domain-like
53187 - Zn-dependent exopeptidases | 0 | DIRECT |
52025,53187
52025 - PA domain
53187 - Zn-dependent exopeptidases | 0 | DIRECT |
47943,47353
47943 - Retrovirus capsid protein, N-terminal core domain
47353 - Retrovirus capsid dimerization domain-like | 0 | DIRECT |
54403,54001
54403 - Cystatin/monellin
54001 - Cysteine proteinases | 0 | DIRECT |
50156,50156
50156 - PDZ domain-like
50156 - PDZ domain-like | 0 | DIRECT |
49854,49854
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
49854,49899
49854 - Spermadhesin, CUB domain
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
74924,54001
74924 - Cap-Gly domain
54001 - Cysteine proteinases | 0 | DIRECT |
52540,89043
52540 - P-loop containing nucleoside triphosphate hydrolases
89043 - Soluble domain of poliovirus core protein 3a | 0 | DIRECT |
58091,49899
58091 - Clostridium neurotoxins, "coiled-coil" domain
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | DIRECT |
49899,50386
49899 - Concanavalin A-like lectins/glucanases
50386 - STI-like | 0 | DIRECT |
52540,54211
52540 - P-loop containing nucleoside triphosphate hydrolases
54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
52743,49785
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | DIRECT |
56487,50494
56487 - SRCR-like
50494 - Trypsin-like serine proteases | 0 | DIRECT |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0 | DIRECT |
46919,53098
46919 - N-terminal Zn binding domain of HIV integrase
53098 - Ribonuclease H-like | 0 | DIRECT |
57414,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like | 0 | DIRECT |
53098,46919
53098 - Ribonuclease H-like
46919 - N-terminal Zn binding domain of HIV integrase | 0 | DIRECT |
55920,46785
55920 - Creatinase/aminopeptidase
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
57850,54001
57850 - RING/U-box
54001 - Cysteine proteinases | 0 | DIRECT |
53187,49464
53187 - Zn-dependent exopeptidases
49464 - Carboxypeptidase regulatory domain-like | 0 | DIRECT |
47986,47986
47986 - DEATH domain
47986 - DEATH domain | 0 | DIRECT |
55486,82895
55486 - Metalloproteases ("zincins"), catalytic domain
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | DIRECT |
57535,53300
57535 - Complement control module/SCR domain
53300 - vWA-like | 0 | DIRECT |
53335,56672
53335 - S-adenosyl-L-methionine-dependent methyltransferases
56672 - DNA/RNA polymerases | 0 | DIRECT |
55486,49899
55486 - Metalloproteases ("zincins"), catalytic domain
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0 | DIRECT |
54001,46934
54001 - Cysteine proteinases
46934 - UBA-like | 0 | DIRECT |
140367,143076
140367 - Coronavirus NSP7-like
143076 - Coronavirus NSP8-like | 0 | DIRECT |
55486,51120
55486 - Metalloproteases ("zincins"), catalytic domain
51120 - beta-Roll | 0 | DIRECT |
89043,50494
89043 - Soluble domain of poliovirus core protein 3a
50494 - Trypsin-like serine proteases | 0 | DIRECT |
57630,57196
57630 - GLA-domain
57196 - EGF/Laminin | 0 | DIRECT |
56601,69189
56601 - beta-lactamase/transpeptidase-like
69189 - Penicillin-binding protein associated domain | 0 | DIRECT |
50156,52096
50156 - PDZ domain-like
52096 - ClpP/crotonase | 0 | DIRECT |
82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
82671,49854
82671 - SEA domain
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
56672,53098
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like | 0 | DIRECT |
57196,49854
57196 - EGF/Laminin
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
50630,56672
50630 - Acid proteases
56672 - DNA/RNA polymerases | 0 | DIRECT |
81761,53474
81761 - X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal domain
53474 - alpha/beta-Hydrolases | 0 | DIRECT |
53300,50494
53300 - vWA-like
50494 - Trypsin-like serine proteases | 0 | DIRECT |
50494,52540
50494 - Trypsin-like serine proteases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
54001,144232
54001 - Cysteine proteinases
144232 - HIT/MYND zinc finger-like | 0 | DIRECT |
88633,50494
88633 - Positive stranded ssRNA viruses
50494 - Trypsin-like serine proteases | 0 | DIRECT |
63411,63411
63411 - LuxS/MPP-like metallohydrolase
63411 - LuxS/MPP-like metallohydrolase | 0 | DIRECT |
52317,141986
52317 - Class I glutamine amidotransferase-like
141986 - LD-carboxypeptidase A C-terminal domain-like | 0 | DIRECT |
53335,142877
53335 - S-adenosyl-L-methionine-dependent methyltransferases
142877 - EndoU-like | 0 | DIRECT |
55486,57552
55486 - Metalloproteases ("zincins"), catalytic domain
57552 - Blood coagulation inhibitor (disintegrin) | 0 | DIRECT |
53187,47672
53187 - Zn-dependent exopeptidases
47672 - Transferrin receptor-like dimerisation domain | 0 | DIRECT |
50993,53474
50993 - Peptidase/esterase 'gauge' domain
53474 - alpha/beta-Hydrolases | 0 | DIRECT |
53098,50122
53098 - Ribonuclease H-like
50122 - DNA-binding domain of retroviral integrase | 0 | DIRECT |
49854,50494
49854 - Spermadhesin, CUB domain
50494 - Trypsin-like serine proteases | 0 | DIRECT |
49758,47473
49758 - Calpain large subunit, middle domain (domain III)
47473 - EF-hand | 0 | DIRECT |
49899,49854
49899 - Concanavalin A-like lectins/glucanases
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
49854,82895
49854 - Spermadhesin, CUB domain
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
55486,58091
55486 - Metalloproteases ("zincins"), catalytic domain
58091 - Clostridium neurotoxins, "coiled-coil" domain | 0 | DIRECT |
75001,54001
75001 - Dipeptidyl peptidase I (cathepsin C), exclusion domain
54001 - Cysteine proteinases | 0 | DIRECT |
159936,53335
159936 - NSP3A-like
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0 | DIRECT |
53474,49785
53474 - alpha/beta-Hydrolases
49785 - Galactose-binding domain-like | 0 | DIRECT |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0 | DIRECT |
82671,57424
82671 - SEA domain
57424 - LDL receptor-like module | 0 | DIRECT |
100895,56487
100895 - Kazal-type serine protease inhibitors
56487 - SRCR-like | 0 | DIRECT |
50886,50886
50886 - D-aminopeptidase, middle and C-terminal domains
50886 - D-aminopeptidase, middle and C-terminal domains | 0 | DIRECT |
55486,49854
55486 - Metalloproteases ("zincins"), catalytic domain
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
47836,47943
47836 - Retroviral matrix proteins
47943 - Retrovirus capsid protein, N-terminal core domain | 0 | DIRECT |
49854,57535
49854 - Spermadhesin, CUB domain
57535 - Complement control module/SCR domain | 0 | DIRECT |
56487,57424
56487 - SRCR-like
57424 - LDL receptor-like module | 0 | DIRECT |
101816,144246
101816 - Replicase NSP9
144246 - Coronavirus NSP10-like | 0 | DIRECT |
49854,57424
49854 - Spermadhesin, CUB domain
57424 - LDL receptor-like module | 0 | DIRECT |
74924,74924
74924 - Cap-Gly domain
74924 - Cap-Gly domain | 0 | DIRECT |
49854,57196
49854 - Spermadhesin, CUB domain
57196 - EGF/Laminin | 0 | DIRECT |
55486,57440
55486 - Metalloproteases ("zincins"), catalytic domain
57440 - Kringle-like | 0 | DIRECT |
53092,53092
53092 - Creatinase/prolidase N-terminal domain
53092 - Creatinase/prolidase N-terminal domain | 0 | DIRECT |
143076,101816
143076 - Coronavirus NSP8-like
101816 - Replicase NSP9 | 0 | DIRECT |
57535,50494
57535 - Complement control module/SCR domain
50494 - Trypsin-like serine proteases | 0 | DIRECT |
57440,57196
57440 - Kringle-like
57196 - EGF/Laminin | 0 | DIRECT |
46785,51306
46785 - "Winged helix" DNA-binding domain
51306 - LexA/Signal peptidase | 0 | DIRECT |
54236,54001
54236 - Ubiquitin-like
54001 - Cysteine proteinases | 0 | DIRECT |
143791,143791
143791 - DUSP-like
143791 - DUSP-like | 0 | DIRECT |
49899,49599
49899 - Concanavalin A-like lectins/glucanases
49599 - TRAF domain-like | 0 | DIRECT |
52743,52025
52743 - Subtilisin-like
52025 - PA domain | 0 | DIRECT |
49599,54001
49599 - TRAF domain-like
54001 - Cysteine proteinases | 0 | DIRECT |
57424,56487
57424 - LDL receptor-like module
56487 - SRCR-like | 0 | DIRECT |
57424,50494
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | DIRECT |
63737,55486
63737 - Leukotriene A4 hydrolase N-terminal domain
55486 - Metalloproteases ("zincins"), catalytic domain | 0.0000000000001834 | DIRECT |
56672,88633
56672 - DNA/RNA polymerases
88633 - Positive stranded ssRNA viruses | 0.00000000006696 | DIRECT |
53187,55031
53187 - Zn-dependent exopeptidases
55031 - Bacterial exopeptidase dimerisation domain | 0.00000005298 | DIRECT |
90209,90209
90209 - Ran binding protein zinc finger-like
90209 - Ran binding protein zinc finger-like | 0.000009608 | DIRECT |
52540,142877
52540 - P-loop containing nucleoside triphosphate hydrolases
142877 - EndoU-like | 0.00009164 | DIRECT |
49785,57184
49785 - Galactose-binding domain-like
57184 - Growth factor receptor domain | 0.0006616 | DIRECT |
56672,52540
56672 - DNA/RNA polymerases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.009008 | INHERITED FROM: Omega peptidases || Ubiquitinyl hydrolase 1 |
55486,48371
55486 - Metalloproteases ("zincins"), catalytic domain
48371 - ARM repeat | 0.9756 | INHERITED FROM: Aminopeptidase B || Aminopeptidases |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: Flavivirin || Nuclear-inclusion-a endopeptidase || Serine endopeptidases || Helper-component proteinase || Cysteine endopeptidases || Hepacivirin |
52540,56672
52540 - P-loop containing nucleoside triphosphate hydrolases
56672 - DNA/RNA polymerases | 1 | INHERITED FROM: Calicivirin || Cysteine endopeptidases |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57196,50494
57196 - EGF/Laminin
50494 - Trypsin-like serine proteases | 0 | Direct |
47353,57756
47353 - Retrovirus capsid dimerization domain-like
57756 - Retrovirus zinc finger-like domains | 0 | Direct |
49464,53187
49464 - Carboxypeptidase regulatory domain-like
53187 - Zn-dependent exopeptidases | 0 | Direct |
57184,50494
57184 - Growth factor receptor domain
50494 - Trypsin-like serine proteases | 0 | Direct |
56983,81296
56983 - Viral glycoprotein, central and dimerisation domains
81296 - E set domains | 0 | Direct |
57756,50630
57756 - Retrovirus zinc finger-like domains
50630 - Acid proteases | 0 | Direct |
57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | Direct |
57630,57440
57630 - GLA-domain
57440 - Kringle-like | 0 | Direct |
159936,52949
159936 - NSP3A-like
52949 - Macro domain-like | 0 | Direct |
56601,50886
56601 - beta-lactamase/transpeptidase-like
50886 - D-aminopeptidase, middle and C-terminal domains | 0 | Direct |
54001,49758
54001 - Cysteine proteinases
49758 - Calpain large subunit, middle domain (domain III) | 0 | Direct |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0 | Direct |
57630,57184
57630 - GLA-domain
57184 - Growth factor receptor domain | 0 | Direct |
54001,143791
54001 - Cysteine proteinases
143791 - DUSP-like | 0 | Direct |
47473,144091
47473 - EF-hand
144091 - Rhomboid-like | 0 | Direct |
54001,88633
54001 - Cysteine proteinases
88633 - Positive stranded ssRNA viruses | 0 | Direct |
53092,55920
53092 - Creatinase/prolidase N-terminal domain
55920 - Creatinase/aminopeptidase | 0 | Direct |
57424,49854
57424 - LDL receptor-like module
49854 - Spermadhesin, CUB domain | 0 | Direct |
48371,54001
48371 - ARM repeat
54001 - Cysteine proteinases | 0 | Direct |
50494,50156
50494 - Trypsin-like serine proteases
50156 - PDZ domain-like | 0 | Direct |
50494,56672
50494 - Trypsin-like serine proteases
56672 - DNA/RNA polymerases | 0 | Direct |
101821,53187
101821 - Aminopeptidase/glucanase lid domain
53187 - Zn-dependent exopeptidases | 0 | Direct |
82171,53474
82171 - DPP6 N-terminal domain-like
53474 - alpha/beta-Hydrolases | 0 | Direct |
54897,52743
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like | 0 | Direct |
88633,88633
88633 - Positive stranded ssRNA viruses
88633 - Positive stranded ssRNA viruses | 0 | Direct |
47986,52129
47986 - DEATH domain
52129 - Caspase-like | 0 | Direct |
54897,53187
54897 - Protease propeptides/inhibitors
53187 - Zn-dependent exopeptidases | 0 | Direct |
103642,55920
103642 - Sec-C motif
55920 - Creatinase/aminopeptidase | 0 | Direct |
57603,57440
57603 - FnI-like domain
57440 - Kringle-like | 0 | Direct |
52949,53187
52949 - Macro domain-like
53187 - Zn-dependent exopeptidases | 0 | Direct |
52025,53187
52025 - PA domain
53187 - Zn-dependent exopeptidases | 0 | Direct |
47943,47353
47943 - Retrovirus capsid protein, N-terminal core domain
47353 - Retrovirus capsid dimerization domain-like | 0 | Direct |
54403,54001
54403 - Cystatin/monellin
54001 - Cysteine proteinases | 0 | Direct |
50156,50156
50156 - PDZ domain-like
50156 - PDZ domain-like | 0 | Direct |
49854,49854
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain | 0 | Direct |
49854,49899
49854 - Spermadhesin, CUB domain
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
74924,54001
74924 - Cap-Gly domain
54001 - Cysteine proteinases | 0 | Direct |
52540,89043
52540 - P-loop containing nucleoside triphosphate hydrolases
89043 - Soluble domain of poliovirus core protein 3a | 0 | Direct |
58091,49899
58091 - Clostridium neurotoxins, "coiled-coil" domain
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | Direct |
49899,50386
49899 - Concanavalin A-like lectins/glucanases
50386 - STI-like | 0 | Direct |
52540,54211
52540 - P-loop containing nucleoside triphosphate hydrolases
54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
52743,49785
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | Direct |
56487,50494
56487 - SRCR-like
50494 - Trypsin-like serine proteases | 0 | Direct |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0 | Direct |
46919,53098
46919 - N-terminal Zn binding domain of HIV integrase
53098 - Ribonuclease H-like | 0 | Direct |
57414,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like | 0 | Direct |
53098,46919
53098 - Ribonuclease H-like
46919 - N-terminal Zn binding domain of HIV integrase | 0 | Direct |
55920,46785
55920 - Creatinase/aminopeptidase
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
57850,54001
57850 - RING/U-box
54001 - Cysteine proteinases | 0 | Direct |
53187,49464
53187 - Zn-dependent exopeptidases
49464 - Carboxypeptidase regulatory domain-like | 0 | Direct |
47986,47986
47986 - DEATH domain
47986 - DEATH domain | 0 | Direct |
55486,82895
55486 - Metalloproteases ("zincins"), catalytic domain
82895 - TSP-1 type 1 repeat | 0 | Direct |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | Direct |
57535,53300
57535 - Complement control module/SCR domain
53300 - vWA-like | 0 | Direct |
53335,56672
53335 - S-adenosyl-L-methionine-dependent methyltransferases
56672 - DNA/RNA polymerases | 0 | Direct |
55486,49899
55486 - Metalloproteases ("zincins"), catalytic domain
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0 | Direct |
54001,46934
54001 - Cysteine proteinases
46934 - UBA-like | 0 | Direct |
140367,143076
140367 - Coronavirus NSP7-like
143076 - Coronavirus NSP8-like | 0 | Direct |
55486,51120
55486 - Metalloproteases ("zincins"), catalytic domain
51120 - beta-Roll | 0 | Direct |
89043,50494
89043 - Soluble domain of poliovirus core protein 3a
50494 - Trypsin-like serine proteases | 0 | Direct |
57630,57196
57630 - GLA-domain
57196 - EGF/Laminin | 0 | Direct |
56601,69189
56601 - beta-lactamase/transpeptidase-like
69189 - Penicillin-binding protein associated domain | 0 | Direct |
50156,52096
50156 - PDZ domain-like
52096 - ClpP/crotonase | 0 | Direct |
82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | Direct |
82671,49854
82671 - SEA domain
49854 - Spermadhesin, CUB domain | 0 | Direct |
56672,53098
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like | 0 | Direct |
57196,49854
57196 - EGF/Laminin
49854 - Spermadhesin, CUB domain | 0 | Direct |
50630,56672
50630 - Acid proteases
56672 - DNA/RNA polymerases | 0 | Direct |
81761,53474
81761 - X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal domain
53474 - alpha/beta-Hydrolases | 0 | Direct |
53300,50494
53300 - vWA-like
50494 - Trypsin-like serine proteases | 0 | Direct |
50494,52540
50494 - Trypsin-like serine proteases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
54001,144232
54001 - Cysteine proteinases
144232 - HIT/MYND zinc finger-like | 0 | Direct |
88633,50494
88633 - Positive stranded ssRNA viruses
50494 - Trypsin-like serine proteases | 0 | Direct |
63411,63411
63411 - LuxS/MPP-like metallohydrolase
63411 - LuxS/MPP-like metallohydrolase | 0 | Direct |
52317,141986
52317 - Class I glutamine amidotransferase-like
141986 - LD-carboxypeptidase A C-terminal domain-like | 0 | Direct |
53335,142877
53335 - S-adenosyl-L-methionine-dependent methyltransferases
142877 - EndoU-like | 0 | Direct |
55486,57552
55486 - Metalloproteases ("zincins"), catalytic domain
57552 - Blood coagulation inhibitor (disintegrin) | 0 | Direct |
53187,47672
53187 - Zn-dependent exopeptidases
47672 - Transferrin receptor-like dimerisation domain | 0 | Direct |
50993,53474
50993 - Peptidase/esterase 'gauge' domain
53474 - alpha/beta-Hydrolases | 0 | Direct |
53098,50122
53098 - Ribonuclease H-like
50122 - DNA-binding domain of retroviral integrase | 0 | Direct |
49854,50494
49854 - Spermadhesin, CUB domain
50494 - Trypsin-like serine proteases | 0 | Direct |
49758,47473
49758 - Calpain large subunit, middle domain (domain III)
47473 - EF-hand | 0 | Direct |
49899,49854
49899 - Concanavalin A-like lectins/glucanases
49854 - Spermadhesin, CUB domain | 0 | Direct |
49854,82895
49854 - Spermadhesin, CUB domain
82895 - TSP-1 type 1 repeat | 0 | Direct |
55486,58091
55486 - Metalloproteases ("zincins"), catalytic domain
58091 - Clostridium neurotoxins, "coiled-coil" domain | 0 | Direct |
75001,54001
75001 - Dipeptidyl peptidase I (cathepsin C), exclusion domain
54001 - Cysteine proteinases | 0 | Direct |
159936,53335
159936 - NSP3A-like
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 0 | Direct |
53474,49785
53474 - alpha/beta-Hydrolases
49785 - Galactose-binding domain-like | 0 | Direct |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0 | Direct |
82671,57424
82671 - SEA domain
57424 - LDL receptor-like module | 0 | Direct |
100895,56487
100895 - Kazal-type serine protease inhibitors
56487 - SRCR-like | 0 | Direct |
50886,50886
50886 - D-aminopeptidase, middle and C-terminal domains
50886 - D-aminopeptidase, middle and C-terminal domains | 0 | Direct |
55486,49854
55486 - Metalloproteases ("zincins"), catalytic domain
49854 - Spermadhesin, CUB domain | 0 | Direct |
47836,47943
47836 - Retroviral matrix proteins
47943 - Retrovirus capsid protein, N-terminal core domain | 0 | Direct |
49854,57535
49854 - Spermadhesin, CUB domain
57535 - Complement control module/SCR domain | 0 | Direct |
56487,57424
56487 - SRCR-like
57424 - LDL receptor-like module | 0 | Direct |
101816,144246
101816 - Replicase NSP9
144246 - Coronavirus NSP10-like | 0 | Direct |
49854,57424
49854 - Spermadhesin, CUB domain
57424 - LDL receptor-like module | 0 | Direct |
74924,74924
74924 - Cap-Gly domain
74924 - Cap-Gly domain | 0 | Direct |
49854,57196
49854 - Spermadhesin, CUB domain
57196 - EGF/Laminin | 0 | Direct |
55486,57440
55486 - Metalloproteases ("zincins"), catalytic domain
57440 - Kringle-like | 0 | Direct |
53092,53092
53092 - Creatinase/prolidase N-terminal domain
53092 - Creatinase/prolidase N-terminal domain | 0 | Direct |
143076,101816
143076 - Coronavirus NSP8-like
101816 - Replicase NSP9 | 0 | Direct |
57535,50494
57535 - Complement control module/SCR domain
50494 - Trypsin-like serine proteases | 0 | Direct |
57440,57196
57440 - Kringle-like
57196 - EGF/Laminin | 0 | Direct |
46785,51306
46785 - "Winged helix" DNA-binding domain
51306 - LexA/Signal peptidase | 0 | Direct |
54236,54001
54236 - Ubiquitin-like
54001 - Cysteine proteinases | 0 | Direct |
143791,143791
143791 - DUSP-like
143791 - DUSP-like | 0 | Direct |
49899,49599
49899 - Concanavalin A-like lectins/glucanases
49599 - TRAF domain-like | 0 | Direct |
52743,52025
52743 - Subtilisin-like
52025 - PA domain | 0 | Direct |
49599,54001
49599 - TRAF domain-like
54001 - Cysteine proteinases | 0 | Direct |
57424,56487
57424 - LDL receptor-like module
56487 - SRCR-like | 0 | Direct |
57424,50494
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | Direct |
63737,55486
63737 - Leukotriene A4 hydrolase N-terminal domain
55486 - Metalloproteases ("zincins"), catalytic domain | 0.0000000000001834 | Direct |
56672,88633
56672 - DNA/RNA polymerases
88633 - Positive stranded ssRNA viruses | 0.00000000006696 | Direct |
53187,55031
53187 - Zn-dependent exopeptidases
55031 - Bacterial exopeptidase dimerisation domain | 0.00000005298 | Direct |
90209,90209
90209 - Ran binding protein zinc finger-like
90209 - Ran binding protein zinc finger-like | 0.000009608 | Direct |
52540,142877
52540 - P-loop containing nucleoside triphosphate hydrolases
142877 - EndoU-like | 0.00009164 | Direct |
49785,57184
49785 - Galactose-binding domain-like
57184 - Growth factor receptor domain | 0.0006616 | Direct |
56672,52540
56672 - DNA/RNA polymerases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.009008 | Inherited |
55486,48371
55486 - Metalloproteases ("zincins"), catalytic domain
48371 - ARM repeat | 0.9756 | Inherited |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 1 | Inherited |
52540,56672
52540 - P-loop containing nucleoside triphosphate hydrolases
56672 - DNA/RNA polymerases | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEO level: Least Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
47090,55486,57440
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
57440 - Kringle-like | 0 | DIRECT |
81761,53474,49785
81761 - X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal domain
53474 - alpha/beta-Hydrolases
49785 - Galactose-binding domain-like | 0 | DIRECT |
89043,50494,56672
89043 - Soluble domain of poliovirus core protein 3a
50494 - Trypsin-like serine proteases
56672 - DNA/RNA polymerases | 0 | DIRECT |
57440,57440,57440
57440 - Kringle-like
57440 - Kringle-like
57440 - Kringle-like | 0 | DIRECT |
57196,49854,57535
57196 - EGF/Laminin
49854 - Spermadhesin, CUB domain
57535 - Complement control module/SCR domain | 0 | DIRECT |
49854,49854,50494
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain
50494 - Trypsin-like serine proteases | 0 | DIRECT |
50494,52540,52540
50494 - Trypsin-like serine proteases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
54001,143791,143791
54001 - Cysteine proteinases
143791 - DUSP-like
143791 - DUSP-like | 0 | DIRECT |
57630,57196,57196
57630 - GLA-domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | DIRECT |
55486,58091,49899
55486 - Metalloproteases ("zincins"), catalytic domain
58091 - Clostridium neurotoxins, "coiled-coil" domain
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
53098,46919,53098
53098 - Ribonuclease H-like
46919 - N-terminal Zn binding domain of HIV integrase
53098 - Ribonuclease H-like | 0 | DIRECT |
50494,52540,89043
50494 - Trypsin-like serine proteases
52540 - P-loop containing nucleoside triphosphate hydrolases
89043 - Soluble domain of poliovirus core protein 3a | 0 | DIRECT |
55486,49899,49599
55486 - Metalloproteases ("zincins"), catalytic domain
49899 - Concanavalin A-like lectins/glucanases
49599 - TRAF domain-like | 0 | DIRECT |
57756,50630,56672
57756 - Retrovirus zinc finger-like domains
50630 - Acid proteases
56672 - DNA/RNA polymerases | 0 | DIRECT |
57603,57440,57440
57603 - FnI-like domain
57440 - Kringle-like
57440 - Kringle-like | 0 | DIRECT |
63411,63411,63411
63411 - LuxS/MPP-like metallohydrolase
63411 - LuxS/MPP-like metallohydrolase
63411 - LuxS/MPP-like metallohydrolase | 0 | DIRECT |
82671,49854,49854
82671 - SEA domain
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
49854,49854,57424
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain
57424 - LDL receptor-like module | 0 | DIRECT |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0 | DIRECT |
53092,53092,55920
53092 - Creatinase/prolidase N-terminal domain
53092 - Creatinase/prolidase N-terminal domain
55920 - Creatinase/aminopeptidase | 0 | DIRECT |
140367,143076,101816
140367 - Coronavirus NSP7-like
143076 - Coronavirus NSP8-like
101816 - Replicase NSP9 | 0 | DIRECT |
47836,47943,47353
47836 - Retroviral matrix proteins
47943 - Retrovirus capsid protein, N-terminal core domain
47353 - Retrovirus capsid dimerization domain-like | 0 | DIRECT |
57424,56487,50494
57424 - LDL receptor-like module
56487 - SRCR-like
50494 - Trypsin-like serine proteases | 0 | DIRECT |
53187,49464,53187
53187 - Zn-dependent exopeptidases
49464 - Carboxypeptidase regulatory domain-like
53187 - Zn-dependent exopeptidases | 0 | DIRECT |
56601,50886,50886
56601 - beta-lactamase/transpeptidase-like
50886 - D-aminopeptidase, middle and C-terminal domains
50886 - D-aminopeptidase, middle and C-terminal domains | 0 | DIRECT |
57424,49854,49899
57424 - LDL receptor-like module
49854 - Spermadhesin, CUB domain
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
82895,82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
49854,57196,49854
49854 - Spermadhesin, CUB domain
57196 - EGF/Laminin
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
56487,57424,57424
56487 - SRCR-like
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | DIRECT |
49899,49854,57424
49899 - Concanavalin A-like lectins/glucanases
49854 - Spermadhesin, CUB domain
57424 - LDL receptor-like module | 0 | DIRECT |
49464,53187,49464
49464 - Carboxypeptidase regulatory domain-like
53187 - Zn-dependent exopeptidases
49464 - Carboxypeptidase regulatory domain-like | 0 | DIRECT |
47943,47353,57756
47943 - Retrovirus capsid protein, N-terminal core domain
47353 - Retrovirus capsid dimerization domain-like
57756 - Retrovirus zinc finger-like domains | 0 | DIRECT |
49854,49899,49854
49854 - Spermadhesin, CUB domain
49899 - Concanavalin A-like lectins/glucanases
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
56672,53098,46919
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like
46919 - N-terminal Zn binding domain of HIV integrase | 0 | DIRECT |
100895,56487,57424
100895 - Kazal-type serine protease inhibitors
56487 - SRCR-like
57424 - LDL receptor-like module | 0 | DIRECT |
46919,53098,50122
46919 - N-terminal Zn binding domain of HIV integrase
53098 - Ribonuclease H-like
50122 - DNA-binding domain of retroviral integrase | 0 | DIRECT |
49854,57424,57424
49854 - Spermadhesin, CUB domain
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | DIRECT |
50494,56672,88633
50494 - Trypsin-like serine proteases
56672 - DNA/RNA polymerases
88633 - Positive stranded ssRNA viruses | 0 | DIRECT |
88633,88633,88633
88633 - Positive stranded ssRNA viruses
88633 - Positive stranded ssRNA viruses
88633 - Positive stranded ssRNA viruses | 0 | DIRECT |
57630,57440,57440
57630 - GLA-domain
57440 - Kringle-like
57440 - Kringle-like | 0 | DIRECT |
52540,89043,50494
52540 - P-loop containing nucleoside triphosphate hydrolases
89043 - Soluble domain of poliovirus core protein 3a
50494 - Trypsin-like serine proteases | 0 | DIRECT |
57424,57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | DIRECT |
54897,52743,49785
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | DIRECT |
57535,57535,53300
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
53300 - vWA-like | 0 | DIRECT |
50494,52540,56672
50494 - Trypsin-like serine proteases
52540 - P-loop containing nucleoside triphosphate hydrolases
56672 - DNA/RNA polymerases | 0 | DIRECT |
58091,49899,50386
58091 - Clostridium neurotoxins, "coiled-coil" domain
49899 - Concanavalin A-like lectins/glucanases
50386 - STI-like | 0 | DIRECT |
57535,57535,50494
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
50494 - Trypsin-like serine proteases | 0 | DIRECT |
55486,49854,49854
55486 - Metalloproteases ("zincins"), catalytic domain
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
54001,88633,88633
54001 - Cysteine proteinases
88633 - Positive stranded ssRNA viruses
88633 - Positive stranded ssRNA viruses | 0 | DIRECT |
143076,101816,144246
143076 - Coronavirus NSP8-like
101816 - Replicase NSP9
144246 - Coronavirus NSP10-like | 0 | DIRECT |
50494,50156,50156
50494 - Trypsin-like serine proteases
50156 - PDZ domain-like
50156 - PDZ domain-like | 0 | DIRECT |
52743,49785,57184
52743 - Subtilisin-like
49785 - Galactose-binding domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
57630,57184,50494
57630 - GLA-domain
57184 - Growth factor receptor domain
50494 - Trypsin-like serine proteases | 0 | DIRECT |
57424,57424,50494
57424 - LDL receptor-like module
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | DIRECT |
47986,47986,52129
47986 - DEATH domain
47986 - DEATH domain
52129 - Caspase-like | 0 | DIRECT |
47353,57756,50630
47353 - Retrovirus capsid dimerization domain-like
57756 - Retrovirus zinc finger-like domains
50630 - Acid proteases | 0 | DIRECT |
57414,57440,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like
57440 - Kringle-like | 0 | DIRECT |
55486,57440,57440
55486 - Metalloproteases ("zincins"), catalytic domain
57440 - Kringle-like
57440 - Kringle-like | 0 | DIRECT |
49854,57535,57535
49854 - Spermadhesin, CUB domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | DIRECT |
54001,49758,47473
54001 - Cysteine proteinases
49758 - Calpain large subunit, middle domain (domain III)
47473 - EF-hand | 0 | DIRECT |
52025,53187,47672
52025 - PA domain
53187 - Zn-dependent exopeptidases
47672 - Transferrin receptor-like dimerisation domain | 0 | DIRECT |
57440,57440,50494
57440 - Kringle-like
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0 | DIRECT |
57535,57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | DIRECT |
49854,57424,56487
49854 - Spermadhesin, CUB domain
57424 - LDL receptor-like module
56487 - SRCR-like | 0 | DIRECT |
50630,56672,53098
50630 - Acid proteases
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like | 0 | DIRECT |
88633,50494,52540
88633 - Positive stranded ssRNA viruses
50494 - Trypsin-like serine proteases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
57630,57196,50494
57630 - GLA-domain
57196 - EGF/Laminin
50494 - Trypsin-like serine proteases | 0 | DIRECT |
57196,57196,50494
57196 - EGF/Laminin
57196 - EGF/Laminin
50494 - Trypsin-like serine proteases | 0 | DIRECT |
57535,53300,50494
57535 - Complement control module/SCR domain
53300 - vWA-like
50494 - Trypsin-like serine proteases | 0 | DIRECT |
55486,49854,82895
55486 - Metalloproteases ("zincins"), catalytic domain
49854 - Spermadhesin, CUB domain
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
82671,57424,49854
82671 - SEA domain
57424 - LDL receptor-like module
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
52540,52540,142877
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
142877 - EndoU-like | 0.0008123 | DIRECT |
56672,52540,52540
56672 - DNA/RNA polymerases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.003477 | INHERITED FROM: Omega peptidases || Ubiquitinyl hydrolase 1 |
63737,55486,48371
63737 - Leukotriene A4 hydrolase N-terminal domain
55486 - Metalloproteases ("zincins"), catalytic domain
48371 - ARM repeat | 0.9756 | INHERITED FROM: Aminopeptidase B || Aminopeptidases |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
47090,55486,57440
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
57440 - Kringle-like | 0 | Direct |
81761,53474,49785
81761 - X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal domain
53474 - alpha/beta-Hydrolases
49785 - Galactose-binding domain-like | 0 | Direct |
89043,50494,56672
89043 - Soluble domain of poliovirus core protein 3a
50494 - Trypsin-like serine proteases
56672 - DNA/RNA polymerases | 0 | Direct |
57440,57440,57440
57440 - Kringle-like
57440 - Kringle-like
57440 - Kringle-like | 0 | Direct |
57196,49854,57535
57196 - EGF/Laminin
49854 - Spermadhesin, CUB domain
57535 - Complement control module/SCR domain | 0 | Direct |
49854,49854,50494
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain
50494 - Trypsin-like serine proteases | 0 | Direct |
50494,52540,52540
50494 - Trypsin-like serine proteases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
54001,143791,143791
54001 - Cysteine proteinases
143791 - DUSP-like
143791 - DUSP-like | 0 | Direct |
57630,57196,57196
57630 - GLA-domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | Direct |
55486,58091,49899
55486 - Metalloproteases ("zincins"), catalytic domain
58091 - Clostridium neurotoxins, "coiled-coil" domain
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
53098,46919,53098
53098 - Ribonuclease H-like
46919 - N-terminal Zn binding domain of HIV integrase
53098 - Ribonuclease H-like | 0 | Direct |
50494,52540,89043
50494 - Trypsin-like serine proteases
52540 - P-loop containing nucleoside triphosphate hydrolases
89043 - Soluble domain of poliovirus core protein 3a | 0 | Direct |
55486,49899,49599
55486 - Metalloproteases ("zincins"), catalytic domain
49899 - Concanavalin A-like lectins/glucanases
49599 - TRAF domain-like | 0 | Direct |
57756,50630,56672
57756 - Retrovirus zinc finger-like domains
50630 - Acid proteases
56672 - DNA/RNA polymerases | 0 | Direct |
57603,57440,57440
57603 - FnI-like domain
57440 - Kringle-like
57440 - Kringle-like | 0 | Direct |
63411,63411,63411
63411 - LuxS/MPP-like metallohydrolase
63411 - LuxS/MPP-like metallohydrolase
63411 - LuxS/MPP-like metallohydrolase | 0 | Direct |
82671,49854,49854
82671 - SEA domain
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain | 0 | Direct |
49854,49854,57424
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain
57424 - LDL receptor-like module | 0 | Direct |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0 | Direct |
53092,53092,55920
53092 - Creatinase/prolidase N-terminal domain
53092 - Creatinase/prolidase N-terminal domain
55920 - Creatinase/aminopeptidase | 0 | Direct |
140367,143076,101816
140367 - Coronavirus NSP7-like
143076 - Coronavirus NSP8-like
101816 - Replicase NSP9 | 0 | Direct |
47836,47943,47353
47836 - Retroviral matrix proteins
47943 - Retrovirus capsid protein, N-terminal core domain
47353 - Retrovirus capsid dimerization domain-like | 0 | Direct |
57424,56487,50494
57424 - LDL receptor-like module
56487 - SRCR-like
50494 - Trypsin-like serine proteases | 0 | Direct |
53187,49464,53187
53187 - Zn-dependent exopeptidases
49464 - Carboxypeptidase regulatory domain-like
53187 - Zn-dependent exopeptidases | 0 | Direct |
56601,50886,50886
56601 - beta-lactamase/transpeptidase-like
50886 - D-aminopeptidase, middle and C-terminal domains
50886 - D-aminopeptidase, middle and C-terminal domains | 0 | Direct |
57424,49854,49899
57424 - LDL receptor-like module
49854 - Spermadhesin, CUB domain
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
82895,82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | Direct |
49854,57196,49854
49854 - Spermadhesin, CUB domain
57196 - EGF/Laminin
49854 - Spermadhesin, CUB domain | 0 | Direct |
56487,57424,57424
56487 - SRCR-like
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | Direct |
49899,49854,57424
49899 - Concanavalin A-like lectins/glucanases
49854 - Spermadhesin, CUB domain
57424 - LDL receptor-like module | 0 | Direct |
49464,53187,49464
49464 - Carboxypeptidase regulatory domain-like
53187 - Zn-dependent exopeptidases
49464 - Carboxypeptidase regulatory domain-like | 0 | Direct |
47943,47353,57756
47943 - Retrovirus capsid protein, N-terminal core domain
47353 - Retrovirus capsid dimerization domain-like
57756 - Retrovirus zinc finger-like domains | 0 | Direct |
49854,49899,49854
49854 - Spermadhesin, CUB domain
49899 - Concanavalin A-like lectins/glucanases
49854 - Spermadhesin, CUB domain | 0 | Direct |
56672,53098,46919
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like
46919 - N-terminal Zn binding domain of HIV integrase | 0 | Direct |
100895,56487,57424
100895 - Kazal-type serine protease inhibitors
56487 - SRCR-like
57424 - LDL receptor-like module | 0 | Direct |
46919,53098,50122
46919 - N-terminal Zn binding domain of HIV integrase
53098 - Ribonuclease H-like
50122 - DNA-binding domain of retroviral integrase | 0 | Direct |
49854,57424,57424
49854 - Spermadhesin, CUB domain
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | Direct |
50494,56672,88633
50494 - Trypsin-like serine proteases
56672 - DNA/RNA polymerases
88633 - Positive stranded ssRNA viruses | 0 | Direct |
88633,88633,88633
88633 - Positive stranded ssRNA viruses
88633 - Positive stranded ssRNA viruses
88633 - Positive stranded ssRNA viruses | 0 | Direct |
57630,57440,57440
57630 - GLA-domain
57440 - Kringle-like
57440 - Kringle-like | 0 | Direct |
52540,89043,50494
52540 - P-loop containing nucleoside triphosphate hydrolases
89043 - Soluble domain of poliovirus core protein 3a
50494 - Trypsin-like serine proteases | 0 | Direct |
57424,57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | Direct |
54897,52743,49785
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | Direct |
57535,57535,53300
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
53300 - vWA-like | 0 | Direct |
50494,52540,56672
50494 - Trypsin-like serine proteases
52540 - P-loop containing nucleoside triphosphate hydrolases
56672 - DNA/RNA polymerases | 0 | Direct |
58091,49899,50386
58091 - Clostridium neurotoxins, "coiled-coil" domain
49899 - Concanavalin A-like lectins/glucanases
50386 - STI-like | 0 | Direct |
57535,57535,50494
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
50494 - Trypsin-like serine proteases | 0 | Direct |
55486,49854,49854
55486 - Metalloproteases ("zincins"), catalytic domain
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain | 0 | Direct |
54001,88633,88633
54001 - Cysteine proteinases
88633 - Positive stranded ssRNA viruses
88633 - Positive stranded ssRNA viruses | 0 | Direct |
143076,101816,144246
143076 - Coronavirus NSP8-like
101816 - Replicase NSP9
144246 - Coronavirus NSP10-like | 0 | Direct |
50494,50156,50156
50494 - Trypsin-like serine proteases
50156 - PDZ domain-like
50156 - PDZ domain-like | 0 | Direct |
52743,49785,57184
52743 - Subtilisin-like
49785 - Galactose-binding domain-like
57184 - Growth factor receptor domain | 0 | Direct |
57630,57184,50494
57630 - GLA-domain
57184 - Growth factor receptor domain
50494 - Trypsin-like serine proteases | 0 | Direct |
57424,57424,50494
57424 - LDL receptor-like module
57424 - LDL receptor-like module
50494 - Trypsin-like serine proteases | 0 | Direct |
47986,47986,52129
47986 - DEATH domain
47986 - DEATH domain
52129 - Caspase-like | 0 | Direct |
47353,57756,50630
47353 - Retrovirus capsid dimerization domain-like
57756 - Retrovirus zinc finger-like domains
50630 - Acid proteases | 0 | Direct |
57414,57440,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like
57440 - Kringle-like | 0 | Direct |
55486,57440,57440
55486 - Metalloproteases ("zincins"), catalytic domain
57440 - Kringle-like
57440 - Kringle-like | 0 | Direct |
49854,57535,57535
49854 - Spermadhesin, CUB domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | Direct |
54001,49758,47473
54001 - Cysteine proteinases
49758 - Calpain large subunit, middle domain (domain III)
47473 - EF-hand | 0 | Direct |
52025,53187,47672
52025 - PA domain
53187 - Zn-dependent exopeptidases
47672 - Transferrin receptor-like dimerisation domain | 0 | Direct |
57440,57440,50494
57440 - Kringle-like
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0 | Direct |
57535,57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | Direct |
49854,57424,56487
49854 - Spermadhesin, CUB domain
57424 - LDL receptor-like module
56487 - SRCR-like | 0 | Direct |
50630,56672,53098
50630 - Acid proteases
56672 - DNA/RNA polymerases
53098 - Ribonuclease H-like | 0 | Direct |
88633,50494,52540
88633 - Positive stranded ssRNA viruses
50494 - Trypsin-like serine proteases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
57630,57196,50494
57630 - GLA-domain
57196 - EGF/Laminin
50494 - Trypsin-like serine proteases | 0 | Direct |
57196,57196,50494
57196 - EGF/Laminin
57196 - EGF/Laminin
50494 - Trypsin-like serine proteases | 0 | Direct |
57535,53300,50494
57535 - Complement control module/SCR domain
53300 - vWA-like
50494 - Trypsin-like serine proteases | 0 | Direct |
55486,49854,82895
55486 - Metalloproteases ("zincins"), catalytic domain
49854 - Spermadhesin, CUB domain
82895 - TSP-1 type 1 repeat | 0 | Direct |
82671,57424,49854
82671 - SEA domain
57424 - LDL receptor-like module
49854 - Spermadhesin, CUB domain | 0 | Direct |
52540,52540,142877
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
142877 - EndoU-like | 0.0008123 | Direct |
56672,52540,52540
56672 - DNA/RNA polymerases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.003477 | Inherited |
63737,55486,48371
63737 - Leukotriene A4 hydrolase N-terminal domain
55486 - Metalloproteases ("zincins"), catalytic domain
48371 - ARM repeat | 0.9756 | Inherited |
Plot distribution on phylogenetic tree for Individual Supra-domains annotated by this EC term
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A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
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