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Home > SCOP hierarchy > Formiminotransferase domain of formiminotransferase-cyclodeaminase. superfamily

Formiminotransferase domain of formiminotransferase-cyclodeaminase. superfamily

SCOP classification

Root:	SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:	Alpha and beta proteins (a+b) [ 53931] (376)
Fold:	Ferredoxin-like [ 54861] (59)
Superfamily:	Formiminotransferase domain of formiminotransferase-cyclodeaminase. [ 55116]
Families:	Formiminotransferase domain of formiminotransferase-cyclodeaminase. [ 55117]

Superfamily statistics

	Genomes (319)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	809	5,826	2
Proteins	482	3,139	1

Functional annotation

General category	Metabolism
Detailed category	Transferases

Document: Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Lyases	0	Least Informative	Direct
Enzyme Commission (EC)	Transferring one-carbon groups	0	Least Informative	Direct
Enzyme Commission (EC)	Carbon-nitrogen lyases	0	Informative	Direct
Enzyme Commission (EC)	Hydroxymethyl-, formyl- and related transferases	0	Informative	Direct

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Lyases	0.000008711	Least Informative	Direct
Enzyme Commission (EC)	Transferring one-carbon groups	0	Moderately Informative	Direct
Enzyme Commission (EC)	Ligases	0.02461	Moderately Informative	Inherited
Enzyme Commission (EC)	Hydroxymethyl-, formyl- and related transferases	0	Informative	Direct
Enzyme Commission (EC)	Carbon-nitrogen lyases	0.00000000001168	Informative	Direct
Enzyme Commission (EC)	Ammonia-lyases	0	Highly Informative	Direct
Enzyme Commission (EC)	Cyclo-ligases	0.00000003309	Highly Informative	Direct

Document: EC annotation of SCOP domains

InterPro annotation

Cross references IPR004227 SSF55116 Protein matches

Abstract
This entry represents the formiminotransferase (FT) domain of formiminotransferase-cyclodeaminase (FTCD), which forms a homodimer, with each protomer being comprised of two subdomains. Tetrahydrofolate (THF)-dependent glutamate formiminotransferase is involved in the histidine utilization pathway. This enzyme interconverts L-glutamate and N-formimino-L-glutamate. The enzyme is bifunctional as it also catalyzes the cyclodeaminase reaction on N-formimino-THF, converting it to 5,10-methenyl-THF and releasing ammonia; part of the process of regenerating THF. This model covers enzymes from metazoa as well as Gram-positive bacteria and archaea. In humans, deficiency of this enzyme results in a disease phenotype [ PubMed 12815595]. The crystal structure of the enzyme has been studied in the context of the catalytic mechanism [ PubMed 10673422].

InterPro database

PDBeMotif information about ligands, sequence and structure motifs

Cross references

PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Formiminotransferase domain of formiminotransferase-cyclodeaminase. domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Formiminotransferase domain of formiminotransferase-cyclodeaminase. superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Enzyme Commission (EC) · Internal database links ]