Thymidylate synthase/dCMP hydroxymethylase family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a+b) [ 53931] (376)
• Fold: Thymidylate synthase/dCMP hydroxymethylase [ 55830]
• Superfamily: Thymidylate synthase/dCMP hydroxymethylase [ 55831]
• Family: Thymidylate synthase/dCMP hydroxymethylase [ 55832] (3)

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Family statistics

	Genomes (2,240)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	2,468	20,245	48
Proteins	2,464	20,233	48

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferases	0	0	--	DIRECT
Enzyme Commission (EC)	Thymidylate synthase	0	2.44	--	DIRECT
Enzyme Commission (EC)	Dihydrofolate reductase	0	2.264	--	DIRECT
Enzyme Commission (EC)	Acting on the CH-NH group of donors	0.00000000005363	1.279	--	DIRECT
Enzyme Commission (EC)	Transferring one-carbon groups	0	0.72	Least Informative	DIRECT
Enzyme Commission (EC)	Oxidoreductases	1	0.3212	Least Informative	INHERITED FROM: Dihydrofolate reductase || Acting on the CH-NH group of donors || With NAD(+) or NADP(+) as acceptor
Enzyme Commission (EC)	Methyltransferases	0	0.8169	Moderately Informative	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0.000000000009219	1.511	Informative	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	epidermal cell	0	0.2152	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.227	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	guard cell	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2046	--	DIRECT
Plant ANatomical entity (PAN)	stomatal complex	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1621	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2224	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || guard cell || shoot system || portion of plant tissue || stomatal complex || epidermis || epidermal cell || shoot epidermal cell || plant cell || shoot epidermis
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: guard cell || shoot epidermal cell || stomatal complex || shoot system || shoot epidermis

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Thymidylate synthase	0	2.929	--	DIRECT
Enzyme Commission (EC)	Dihydrofolate reductase	0	2.628	--	DIRECT
Enzyme Commission (EC)	Deoxycytidylate 5-hydroxymethyltransferase	0.0000000001041	3.23	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0.3972	Least Informative	DIRECT
Enzyme Commission (EC)	Oxidoreductases	1	0.7328	Least Informative	INHERITED FROM: With NAD(+) or NADP(+) as acceptor || Dihydrofolate reductase || Acting on the CH-NH group of donors
Enzyme Commission (EC)	Transferring one-carbon groups	0	1.161	Moderately Informative	DIRECT
Enzyme Commission (EC)	Methyltransferases	0	1.257	Informative	DIRECT
Enzyme Commission (EC)	Acting on the CH-NH group of donors	0.00000000001863	1.686	Informative	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0.00000000000246	1.907	Highly Informative	DIRECT
Enzyme Commission (EC)	Hydroxymethyl-, formyl- and related transferases	1	1.999	Highly Informative	INHERITED FROM: Deoxycytidylate 5-hydroxymethyltransferase

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