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CTD Chemicals (CC): Chemical Actions and Uses 
(show info)
Biomedical Ontology
Like Gene Ontology (GO), biomedical ontology such as phenotype ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Biomedical ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI’s thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology Based on YP which is the major contributor to the ‘Ascomycete phenotype ontology’, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- UniProtKB KeyWords (KW) Ontology Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- CTD Diseases (CD) Ontology CD is MEDIC disease vocabulary that is modified by CTD from the "Diseases" [C] branch of Medical Subject Headings (MeSH), combined with genetic disorders from the Online Mendelian Inheritance in OMIM database.
- CTD Chemicals (CC) Ontology CC is chemical vocabulary that is adapted by CTD from the "Chemicals and Drugs" category and Supplementary Concept Records of Medical Subject Headings (MeSH, a hierarchical vocabulary used to index articles for MEDLINE/PubMed).
Jump to [ Top · Hierarchy · Annotations ]
Root: CC Hierarchy (CTD chemicals from Comparative Toxicogenomics Database)
Jump to [ Top · Hierarchy ]
Superfamily( show details)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| occludin/ELL-like | 0 | DIRECT |
| Ribosomal protein L30p/L7e | 0 | DIRECT |
| DEK C-terminal domain | 0 | DIRECT |
| BAG domain | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| CCHHC domain | 0 | DIRECT |
| G protein-binding domain | 0 | DIRECT |
| beta-lactamase/transpeptidase-like | 0 | DIRECT |
| GHMP Kinase, C-terminal domain | 0 | DIRECT |
| Thyroglobulin type-1 domain | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| FAD-dependent thiol oxidase | 0 | DIRECT |
| PAH2 domain | 0 | DIRECT |
| Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
| EPT/RTPC-like | 0 | DIRECT |
| MAPEG domain-like | 0 | DIRECT |
| Protein serine/threonine phosphatase 2C, C-terminal domain | 0 | DIRECT |
| Nucleoplasmin-like core domain | 0 | DIRECT |
| P-domain of calnexin/calreticulin | 0 | DIRECT |
| AhpD-like | 0 | DIRECT |
| LanC-like | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| MgtE membrane domain-like | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| Indolic compounds 2,3-dioxygenase-like | 0 | DIRECT |
| Nicotinate/Quinolinate PRTase C-terminal domain-like | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | DIRECT |
| Anaphylotoxins (complement system) | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| Metallothionein | 0 | DIRECT |
| Phosphoenolpyruvate/pyruvate domain | 0 | DIRECT |
| HMA, heavy metal-associated domain | 0 | DIRECT |
| ITPase-like | 0 | DIRECT |
| Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain | 0 | DIRECT |
| ATP-dependent DNA ligase DNA-binding domain | 0 | DIRECT |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
| GTF2I-like repeat | 0 | DIRECT |
| BSD domain-like | 0 | DIRECT |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | DIRECT |
| Bcl-2 inhibitors of programmed cell death | 0 | DIRECT |
| Eferin C-derminal domain-like | 0 | DIRECT |
| Proteasome activator | 0 | DIRECT |
| N-terminal domain of cbl (N-cbl) | 0 | DIRECT |
| PurM N-terminal domain-like | 0 | DIRECT |
| WGR domain-like | 0 | DIRECT |
| A heparin-binding domain | 0 | DIRECT |
| Fibrinogen coiled-coil and central regions | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| HIN-2000 domain-like | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | DIRECT |
| Mitochondrial cytochrome c oxidase subunit VIIa | 0 | DIRECT |
| RGC domain-like | 0 | DIRECT |
| Nucleoporin domain | 0 | DIRECT |
| Hook domain | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| Ribosomal protein S10 | 0 | DIRECT |
| DLC | 0 | DIRECT |
| STAT | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Synuclein | 0 | DIRECT |
| eIF1-like | 0 | DIRECT |
| 3-carboxy-cis,cis-mucoante lactonizing enzyme | 0 | DIRECT |
| C-terminal domain of PLC-beta | 0 | DIRECT |
| Surp module (SWAP domain) | 0 | DIRECT |
| L-aspartase-like | 0 | DIRECT |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
| Transcription factor STAT-4 N-domain | 0 | DIRECT |
| AraD/HMP-PK domain-like | 0 | DIRECT |
| RNase III domain-like | 0 | DIRECT |
| Ribosomal protein L10-like | 0 | DIRECT |
| PurM C-terminal domain-like | 0 | DIRECT |
| PH domain-like | 0.00000001733 | DIRECT |
| Cytochrome P450 | 0.000006162 | DIRECT |
| SH2 domain | 0.00004327 | DIRECT |
| Calponin-homology domain, CH-domain | 0.0001523 | DIRECT |
| Leucine zipper domain | 0.0002459 | DIRECT |
| Nuclear receptor ligand-binding domain | 0.0002551 | DIRECT |
| EGF/Laminin | 0.0003961 | DIRECT |
| SH3-domain | 0.0007124 | DIRECT |
| GTPase activation domain, GAP | 0.0008313 | DIRECT |
| Protein kinase-like (PK-like) | 0.0009187 | DIRECT |
| BRCT domain | 0.0009781 | DIRECT |
| DBL homology domain (DH-domain) | 0.001057 | INHERITED FROM: Antirheumatic Agents |
| Growth factor receptor domain | 0.001724 | INHERITED FROM: Gonadal Hormones || Insulins || Antineoplastic Agents || Physiological Effects of Drugs || Hormones, Hormone Substitutes, and Hormone Antagonists |
| P-loop containing nucleoside triphosphate hydrolases | 0.002017 | INHERITED FROM: estradiol-17 beta-glucuronide || Anticonvulsants |
| DEATH domain | 0.002267 | INHERITED FROM: Protease Inhibitors || Gonadal Hormones || Gastrointestinal Hormones || Air Pollutants, Occupational || gastrin 17 || Cysteine Proteinase Inhibitors || Hormones, Hormone Substitutes, and Hormone Antagonists |
| Fibronectin type III | 0.002426 | INHERITED FROM: Hormones, Hormone Substitutes, and Hormone Antagonists |
| Caspase-like | 0.003127 | INHERITED FROM: Protease Inhibitors || Gonadal Hormones || Enzyme Inhibitors || Specialty Uses of Chemicals || Estradiol || 2-Methoxyestradiol || Peptide Hormones || Melatonin || Trypsin Inhibitors || Cysteine Proteinase Inhibitors || Hormones, Hormone Substitutes, and Hormone Antagonists |
| Cytochrome b5-like heme/steroid binding domain | 0.004921 | INHERITED FROM: Gonadal Hormones || Progesterone || Hormones, Hormone Substitutes, and Hormone Antagonists |
| Plexin repeat | 0.005184 | INHERITED FROM: Gonadal Hormones || Estradiol || Hormones, Hormone Substitutes, and Hormone Antagonists |
| Kringle-like | 0.008993 | INHERITED FROM: Protease Inhibitors || ethinyl estradiol-desogestrel combination || Medroxyprogesterone Acetate || 17-Hydroxycorticosteroids || Progesterone || Hydroxyprogesterones || Medroxyprogesterone |
| Interleukin 8-like chemokines | 0.009525 | INHERITED FROM: Cosmetics || Coagulants || 11-Hydroxycorticosteroids || Corpus Luteum Hormones || Hematologic Agents || Fludrocortisone || Specialty Uses of Chemicals || Therapeutic Uses || Progesterone Congeners || Perfume || Fulvestrant || 17-Hydroxycorticosteroids || Immunologic Factors |
| Nucleotidylyl transferase | 0.01183 | INHERITED FROM: Enzyme Inhibitors |
| p53-like transcription factors | 0.01251 | INHERITED FROM: Gastrointestinal Hormones || cetrorelix || Gastrins || Peptide Hormones || Pituitary Hormone-Releasing Hormones |
| Integrin domains | 0.01258 | INHERITED FROM: Gonadal Hormones || Corpus Luteum Hormones || Medroxyprogesterone Acetate || Triiodothyronine || Progesterone Congeners || Progesterone || Hormones, Hormone Substitutes, and Hormone Antagonists || Medroxyprogesterone |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0.01266 | INHERITED FROM: Estradiol |
| Cystine-knot cytokines | 0.01598 | INHERITED FROM: Androgens || Hypothalamic Hormones || Somatostatin || Specialty Uses of Chemicals || Estradiol || Peptide Hormones || pasireotide || Gonadotropin-Releasing Hormone || Progesterone || Physiological Effects of Drugs || Hormones, Hormone Substitutes, and Hormone Antagonists |
| FAD/NAD(P)-binding domain | 0.01707 | INHERITED FROM: Toxic Actions |
| Sema domain | 0.01949 | INHERITED FROM: Gonadal Hormones || Estradiol || Hormones, Hormone Substitutes, and Hormone Antagonists |
| Immunoglobulin | 0.02067 | INHERITED FROM: Therapeutic Uses || Protein Kinase Inhibitors |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.02227 | INHERITED FROM: 5-alpha-Dihydroprogesterone || Goserelin || Pesticides || Corticosterone || Hormone Antagonists || Juvenile Hormones || Specialty Uses of Chemicals || tetraiodothyroacetic acid || Invertebrate Hormones || Estriol || Soil Pollutants || Equilin || Cortodoxone || 3,3',5-triiodothyroacetic acid |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.02784 | INHERITED FROM: Enzyme Inhibitors |
| C-terminal, gelsolin-like domain of Sec23/24 | 0.02784 | INHERITED FROM: Dihydrotestosterone || Enzyme Inhibitors |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.02784 | INHERITED FROM: Enzyme Inhibitors |
| Serpins | 0.03244 | INHERITED FROM: ethinyl estradiol-desogestrel combination || Gonadal Hormones || 11-Hydroxycorticosteroids || Estrogenic Steroids, Alkylated || Hormones, Hormone Substitutes, and Hormone Antagonists |
| Rhodanese/Cell cycle control phosphatase | 0.03305 | INHERITED FROM: Environmental Pollutants || Toxic Actions |
| GST C-terminal domain-like | 0.03501 | INHERITED FROM: Enzyme Inhibitors || 17-Ketosteroids || Androstenedione |
| GLA-domain | 0.03512 | INHERITED FROM: ethinyl estradiol-desogestrel combination || Reproductive Control Agents || Estrogenic Steroids, Alkylated || Medroxyprogesterone Acetate || estradiol valerate-dienogest || norgestimate, ethinyl estradiol drug combination || dienogest || estradiol, norethindrone drug combination || Nandrolone || Medroxyprogesterone |
| Arginase/deacetylase | 0.03512 | INHERITED FROM: Gonadal Hormones || Estradiol Congeners || Estradiol || Physiological Effects of Drugs || Hormones, Hormone Substitutes, and Hormone Antagonists |
| 4-helical cytokines | 0.04259 | INHERITED FROM: Cardiovascular Agents || Nitric Oxide Donors || Cosmetics || Agglutinins || Coagulants || Hydrocortisone || 11-Hydroxycorticosteroids || Corpus Luteum Hormones || Medroxyprogesterone Acetate || Hematologic Agents || Pituitary Hormones, Anterior || Specialty Uses of Chemicals || Estrogens, Conjugated (USP) || Adrenal Cortex Hormones || Progesterone Congeners || Perfume || Peptide Hormones || Protein Kinase Inhibitors || 17-Hydroxycorticosteroids || Immunologic Factors || Medroxyprogesterone |
| NAD(P)-binding Rossmann-fold domains | 0.04878 | INHERITED FROM: Cortisone || Adrenal Cortex Hormones || Androstenedione || Androstenediol || Estrone |
| Ribosomal protein S5 domain 2-like | 0.05317 | INHERITED FROM: Enzyme Inhibitors |
| MHC antigen-recognition domain | 0.05613 | INHERITED FROM: Protease Inhibitors || Antirheumatic Agents || Angiotensin-Converting Enzyme Inhibitors || Therapeutic Uses |
| dsRNA-binding domain-like | 0.05857 | INHERITED FROM: Enzyme Inhibitors || Molecular Mechanisms of Pharmacological Action |
| Inhibitor of apoptosis (IAP) repeat | 0.06309 | INHERITED FROM: Gastrointestinal Hormones || Gastrins || Peptide Hormones |
| VHP, Villin headpiece domain | 0.06309 | INHERITED FROM: Estradiol |
| Integrin alpha N-terminal domain | 0.06873 | INHERITED FROM: Corpus Luteum Hormones || Progesterone Congeners || Progesterone |
| Hemopexin-like domain | 0.06873 | INHERITED FROM: Protease Inhibitors || Estradiol Congeners || Phospholipase A2 Inhibitors || Matrix Metalloproteinase Inhibitors || Estradiol || Progesterone |
| PGBD-like | 0.07999 | INHERITED FROM: Protease Inhibitors || Estradiol Congeners || Phospholipase A2 Inhibitors || Matrix Metalloproteinase Inhibitors || Estradiol || Nandrolone || Progesterone || mibolerone |
| Metalloproteases ("zincins"), catalytic domain | 0.08279 | INHERITED FROM: Protease Inhibitors || Phospholipase A2 Inhibitors || Matrix Metalloproteinase Inhibitors || Progesterone || mibolerone |
| Periplasmic binding protein-like II | 0.08931 | INHERITED FROM: Neurotransmitter Agents || Excitatory Amino Acid Agents || Excitatory Amino Acid Agonists |
| Integrin beta tail domain | 0.09375 | INHERITED FROM: Corpus Luteum Hormones || Progesterone Congeners || Progesterone |
| S15/NS1 RNA-binding domain | 0.09375 | INHERITED FROM: Enzyme Inhibitors || Molecular Mechanisms of Pharmacological Action |
| Eukaryotic type KH-domain (KH-domain type I) | 0.1313 | INHERITED FROM: Enzyme Inhibitors || Molecular Mechanisms of Pharmacological Action |
| Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain | 0.1369 | INHERITED FROM: Antirheumatic Agents || Therapeutic Uses |
| post-AAA+ oligomerization domain-like | 0.1379 | INHERITED FROM: Enzyme Inhibitors |
| MFS general substrate transporter | 0.1467 | INHERITED FROM: 3-iodothyronamine || estradiol-17 beta-glucuronide || Thyroid Hormones || Dehydroepiandrosterone || Adrenal Cortex Hormones || Thyronines || Dehydroepiandrosterone Sulfate || Physiological Effects of Drugs || Hormones, Hormone Substitutes, and Hormone Antagonists || estrone sulfate || Thyroxine || Estrone |
| FnI-like domain | 0.1589 | INHERITED FROM: Estrogenic Steroids, Alkylated || Angiotensins || Peptide Hormones |
| A DNA-binding domain in eukaryotic transcription factors | 0.175 | INHERITED FROM: Agrochemicals |
| Cupredoxins | 0.1835 | INHERITED FROM: ethinyl estradiol-desogestrel combination |
| SPOC domain-like | 0.1997 | INHERITED FROM: Enzyme Inhibitors || Molecular Mechanisms of Pharmacological Action |
| Kazal-type serine protease inhibitors | 0.203 | INHERITED FROM: 3-iodothyronamine || Thyroid Hormones || Thyronines || estrone sulfate |
| beta-sandwich domain of Sec23/24 | 0.2094 | INHERITED FROM: Dihydrotestosterone || Enzyme Inhibitors || Testosterone Congeners || Molecular Mechanisms of Pharmacological Action |
| Cytokine | 0.2232 | INHERITED FROM: Hydroxycorticosteroids |
| vWA-like | 0.2312 | INHERITED FROM: Medroxyprogesterone Acetate || Medroxyprogesterone |
| "Winged helix" DNA-binding domain | 0.2383 | INHERITED FROM: mibolerone |
| ARM repeat | 0.2391 | INHERITED FROM: Enzyme Inhibitors || Molecular Mechanisms of Pharmacological Action |
| GroEL equatorial domain-like | 0.2776 | INHERITED FROM: Enzyme Inhibitors || Molecular Mechanisms of Pharmacological Action |
| NAD(P)-linked oxidoreductase | 0.2799 | INHERITED FROM: 5-alpha-Dihydroprogesterone || 11-Hydroxycorticosteroids || Medroxyprogesterone Acetate || Triiodothyronine || Corticosterone || 20-alpha-Dihydroprogesterone || Adrenal Cortex Hormones || 4-hydroxyequilenin-o-quinone || Thyronines || Equilenin || Desoxycorticosterone || tetrahydrodeoxycorticosterone || Thyroxine || Estrone || Medroxyprogesterone || 16-ketoestrone |
| RNA-binding domain, RBD | 0.3025 | INHERITED FROM: Enzyme Inhibitors || Molecular Mechanisms of Pharmacological Action |
| UDP-Glycosyltransferase/glycogen phosphorylase | 0.3038 | INHERITED FROM: Estrogens, Catechol || Hydroxyestrones || 4-hydroxyestrone || Pregnenolone Carbonitrile || 2-Methoxyestradiol || Pregnenolone || Adrenal Cortex Hormones || Estriol || 2-hydroxyestradiol || Androsterone || Estrone |
| Acyl-CoA binding protein | 0.3295 | INHERITED FROM: Testosterone Congeners |
| Hormone receptor domain | 0.3343 | INHERITED FROM: Peptide Hormones || Pituitary Hormone-Releasing Hormones |
| SNF-like | 0.3343 | INHERITED FROM: Specialty Uses of Chemicals || Fluorescent Dyes || Coloring Agents |
| UBA-like | 0.3383 | INHERITED FROM: Enzyme Inhibitors || Molecular Mechanisms of Pharmacological Action |
| Insulin-like | 0.3411 | INHERITED FROM: Hypothalamic Hormones || Hydrocortisone || 11-Hydroxycorticosteroids || Hydroxycorticosteroids || Peptide Hormones || Testosterone || Testosterone Congeners || 17-Hydroxycorticosteroids |
| Cyclin-like | 0.353 | INHERITED FROM: 2-Methoxyestradiol || Fulvestrant |
| ABC transporter transmembrane region | 0.3618 | INHERITED FROM: Central Nervous System Agents || estradiol-17 beta-glucuronide || Methyltestosterone || Peptide Hormones || Anticonvulsants || Progesterone |
| SAP domain | 0.3725 | INHERITED FROM: Enzyme Inhibitors || Molecular Mechanisms of Pharmacological Action |
| Blood coagulation inhibitor (disintegrin) | 0.3837 | INHERITED FROM: Triiodothyronine || Thyronines || Thyroxine |
| GroEL-intermediate domain like | 0.4168 | INHERITED FROM: Enzyme Inhibitors || Molecular Mechanisms of Pharmacological Action |
| Nucleic acid-binding proteins | 0.4208 | INHERITED FROM: Enzyme Inhibitors || Molecular Mechanisms of Pharmacological Action |
| Thioredoxin-like | 0.4279 | INHERITED FROM: 17-Ketosteroids |
| SCOP hierarchy in SUPERFAMILY | 0.4674 | INHERITED FROM: Enzyme Inhibitors || Molecular Mechanisms of Pharmacological Action |
| PYP-like sensor domain (PAS domain) | 0.4745 | INHERITED FROM: Triiodothyronine || Adrenal Cortex Hormones || Fulvestrant || Thyronines || Thyroxine |
| GroEL apical domain-like | 0.4802 | INHERITED FROM: Enzyme Inhibitors || Molecular Mechanisms of Pharmacological Action |
| R3H domain | 0.4998 | INHERITED FROM: Enzyme Inhibitors || Molecular Mechanisms of Pharmacological Action |
| TNF-like | 0.6308 | INHERITED FROM: Medroxyprogesterone Acetate || Hydroxyprogesterones |
| Periplasmic binding protein-like I | 0.7414 | INHERITED FROM: Neurotransmitter Agents || Excitatory Amino Acid Agents || Excitatory Amino Acid Agonists |
| Metallo-hydrolase/oxidoreductase | 0.7596 | INHERITED FROM: Air Pollutants, Occupational |
| Histone-fold | 0.8815 | INHERITED FROM: Air Pollutants |
| HLH, helix-loop-helix DNA-binding domain | 0.9139 | INHERITED FROM: Dihydrotestosterone || testosterone-3-carboxymethyloxime-bovine serum albumin conjugate |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.9268 | INHERITED FROM: Flame Retardants || Neurotransmitter Agents |
| Nicotinic receptor ligand binding domain-like | 0.9268 | INHERITED FROM: Flame Retardants || Neurotransmitter Agents |
| Fibrinogen C-terminal domain-like | 0.9676 | INHERITED FROM: ethinyl estradiol-desogestrel combination || estradiol valerate-dienogest || dienogest || Nandrolone |
| Trypsin-like serine proteases | 1 | INHERITED FROM: Protease Inhibitors || ethinyl estradiol-desogestrel combination || Reproductive Control Agents || Estrogenic Steroids, Alkylated || Medroxyprogesterone Acetate || NuvaRing || estradiol valerate-dienogest || estradiol, norethindrone drug combination || Nandrolone || Medroxyprogesterone |
| L domain-like | 1 | INHERITED FROM: Insulins || Antineoplastic Agents |
| Family A G protein-coupled receptor-like | 1 | INHERITED FROM: Peptide Hormones |
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| occludin/ELL-like | 0 | Direct |
| Ribosomal protein L30p/L7e | 0 | Direct |
| DEK C-terminal domain | 0 | Direct |
| BAG domain | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| CCHHC domain | 0 | Direct |
| G protein-binding domain | 0 | Direct |
| beta-lactamase/transpeptidase-like | 0 | Direct |
| GHMP Kinase, C-terminal domain | 0 | Direct |
| Thyroglobulin type-1 domain | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| FAD-dependent thiol oxidase | 0 | Direct |
| PAH2 domain | 0 | Direct |
| Domain of poly(ADP-ribose) polymerase | 0 | Direct |
| EPT/RTPC-like | 0 | Direct |
| MAPEG domain-like | 0 | Direct |
| Protein serine/threonine phosphatase 2C, C-terminal domain | 0 | Direct |
| Nucleoplasmin-like core domain | 0 | Direct |
| P-domain of calnexin/calreticulin | 0 | Direct |
| AhpD-like | 0 | Direct |
| LanC-like | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| MgtE membrane domain-like | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| Indolic compounds 2,3-dioxygenase-like | 0 | Direct |
| Nicotinate/Quinolinate PRTase C-terminal domain-like | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | Direct |
| Anaphylotoxins (complement system) | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| Metallothionein | 0 | Direct |
| Phosphoenolpyruvate/pyruvate domain | 0 | Direct |
| HMA, heavy metal-associated domain | 0 | Direct |
| ITPase-like | 0 | Direct |
| Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain | 0 | Direct |
| ATP-dependent DNA ligase DNA-binding domain | 0 | Direct |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
| GTF2I-like repeat | 0 | Direct |
| BSD domain-like | 0 | Direct |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | Direct |
| Bcl-2 inhibitors of programmed cell death | 0 | Direct |
| Eferin C-derminal domain-like | 0 | Direct |
| Proteasome activator | 0 | Direct |
| N-terminal domain of cbl (N-cbl) | 0 | Direct |
| PurM N-terminal domain-like | 0 | Direct |
| WGR domain-like | 0 | Direct |
| A heparin-binding domain | 0 | Direct |
| Fibrinogen coiled-coil and central regions | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| HIN-2000 domain-like | 0 | Direct |
| p53 tetramerization domain | 0 | Direct |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | Direct |
| Mitochondrial cytochrome c oxidase subunit VIIa | 0 | Direct |
| RGC domain-like | 0 | Direct |
| Nucleoporin domain | 0 | Direct |
| Hook domain | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| Ribosomal protein S10 | 0 | Direct |
| DLC | 0 | Direct |
| STAT | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Synuclein | 0 | Direct |
| eIF1-like | 0 | Direct |
| 3-carboxy-cis,cis-mucoante lactonizing enzyme | 0 | Direct |
| C-terminal domain of PLC-beta | 0 | Direct |
| Surp module (SWAP domain) | 0 | Direct |
| L-aspartase-like | 0 | Direct |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
| Transcription factor STAT-4 N-domain | 0 | Direct |
| AraD/HMP-PK domain-like | 0 | Direct |
| RNase III domain-like | 0 | Direct |
| Ribosomal protein L10-like | 0 | Direct |
| PurM C-terminal domain-like | 0 | Direct |
| PH domain-like | 0.00000001733 | Direct |
| Cytochrome P450 | 0.000006162 | Direct |
| SH2 domain | 0.00004327 | Direct |
| Calponin-homology domain, CH-domain | 0.0001523 | Direct |
| Leucine zipper domain | 0.0002459 | Direct |
| Nuclear receptor ligand-binding domain | 0.0002551 | Direct |
| EGF/Laminin | 0.0003961 | Direct |
| SH3-domain | 0.0007124 | Direct |
| GTPase activation domain, GAP | 0.0008313 | Direct |
| Protein kinase-like (PK-like) | 0.0009187 | Direct |
| BRCT domain | 0.0009781 | Direct |
| DBL homology domain (DH-domain) | 0.001057 | Inherited |
| Growth factor receptor domain | 0.001724 | Inherited |
| P-loop containing nucleoside triphosphate hydrolases | 0.002017 | Inherited |
| DEATH domain | 0.002267 | Inherited |
| Fibronectin type III | 0.002426 | Inherited |
| Caspase-like | 0.003127 | Inherited |
| Cytochrome b5-like heme/steroid binding domain | 0.004921 | Inherited |
| Plexin repeat | 0.005184 | Inherited |
| Kringle-like | 0.008993 | Inherited |
| Interleukin 8-like chemokines | 0.009525 | Inherited |
| Nucleotidylyl transferase | 0.01183 | Inherited |
| p53-like transcription factors | 0.01251 | Inherited |
| Integrin domains | 0.01258 | Inherited |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0.01266 | Inherited |
| Cystine-knot cytokines | 0.01598 | Inherited |
| FAD/NAD(P)-binding domain | 0.01707 | Inherited |
| Sema domain | 0.01949 | Inherited |
| Immunoglobulin | 0.02067 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.02227 | Inherited |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.02784 | Inherited |
| C-terminal, gelsolin-like domain of Sec23/24 | 0.02784 | Inherited |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.02784 | Inherited |
| Serpins | 0.03244 | Inherited |
| Rhodanese/Cell cycle control phosphatase | 0.03305 | Inherited |
| GST C-terminal domain-like | 0.03501 | Inherited |
| GLA-domain | 0.03512 | Inherited |
| Arginase/deacetylase | 0.03512 | Inherited |
| 4-helical cytokines | 0.04259 | Inherited |
| NAD(P)-binding Rossmann-fold domains | 0.04878 | Inherited |
| Ribosomal protein S5 domain 2-like | 0.05317 | Inherited |
| MHC antigen-recognition domain | 0.05613 | Inherited |
| dsRNA-binding domain-like | 0.05857 | Inherited |
| Inhibitor of apoptosis (IAP) repeat | 0.06309 | Inherited |
| VHP, Villin headpiece domain | 0.06309 | Inherited |
| Integrin alpha N-terminal domain | 0.06873 | Inherited |
| Hemopexin-like domain | 0.06873 | Inherited |
| PGBD-like | 0.07999 | Inherited |
| Metalloproteases ("zincins"), catalytic domain | 0.08279 | Inherited |
| Periplasmic binding protein-like II | 0.08931 | Inherited |
| Integrin beta tail domain | 0.09375 | Inherited |
| S15/NS1 RNA-binding domain | 0.09375 | Inherited |
| Eukaryotic type KH-domain (KH-domain type I) | 0.1313 | Inherited |
| Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain | 0.1369 | Inherited |
| post-AAA+ oligomerization domain-like | 0.1379 | Inherited |
| MFS general substrate transporter | 0.1467 | Inherited |
| FnI-like domain | 0.1589 | Inherited |
| A DNA-binding domain in eukaryotic transcription factors | 0.175 | Inherited |
| Cupredoxins | 0.1835 | Inherited |
| SPOC domain-like | 0.1997 | Inherited |
| Kazal-type serine protease inhibitors | 0.203 | Inherited |
| beta-sandwich domain of Sec23/24 | 0.2094 | Inherited |
| Cytokine | 0.2232 | Inherited |
| vWA-like | 0.2312 | Inherited |
| "Winged helix" DNA-binding domain | 0.2383 | Inherited |
| ARM repeat | 0.2391 | Inherited |
| GroEL equatorial domain-like | 0.2776 | Inherited |
| NAD(P)-linked oxidoreductase | 0.2799 | Inherited |
| RNA-binding domain, RBD | 0.3025 | Inherited |
| UDP-Glycosyltransferase/glycogen phosphorylase | 0.3038 | Inherited |
| Acyl-CoA binding protein | 0.3295 | Inherited |
| Hormone receptor domain | 0.3343 | Inherited |
| SNF-like | 0.3343 | Inherited |
| UBA-like | 0.3383 | Inherited |
| Insulin-like | 0.3411 | Inherited |
| Cyclin-like | 0.353 | Inherited |
| ABC transporter transmembrane region | 0.3618 | Inherited |
| SAP domain | 0.3725 | Inherited |
| Blood coagulation inhibitor (disintegrin) | 0.3837 | Inherited |
| GroEL-intermediate domain like | 0.4168 | Inherited |
| Nucleic acid-binding proteins | 0.4208 | Inherited |
| Thioredoxin-like | 0.4279 | Inherited |
| SCOP hierarchy in SUPERFAMILY | 0.4674 | Inherited |
| PYP-like sensor domain (PAS domain) | 0.4745 | Inherited |
| GroEL apical domain-like | 0.4802 | Inherited |
| R3H domain | 0.4998 | Inherited |
| TNF-like | 0.6308 | Inherited |
| Periplasmic binding protein-like I | 0.7414 | Inherited |
| Metallo-hydrolase/oxidoreductase | 0.7596 | Inherited |
| Histone-fold | 0.8815 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.9139 | Inherited |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.9268 | Inherited |
| Nicotinic receptor ligand binding domain-like | 0.9268 | Inherited |
| Fibrinogen C-terminal domain-like | 0.9676 | Inherited |
| Trypsin-like serine proteases | 1 | Inherited |
| L domain-like | 1 | Inherited |
| Family A G protein-coupled receptor-like | 1 | Inherited |
LINKTO: Domain2BO Download and Domain2BO Algorithm
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Family( show details)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Protein-L-isoaspartyl O-methyltransferase | 0 | DIRECT |
| Netrin-like domain (NTR/C345C module) | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| Diap1 N-terninal region-like | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | DIRECT |
| Formate/glycerate dehydrogenases, substrate-binding domain | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| FAD-dependent thiol oxidase | 0 | DIRECT |
| Alkaline phosphatase | 0 | DIRECT |
| L domain | 0 | DIRECT |
| Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
| IP3 receptor type 1 binding core, domain 2 | 0 | DIRECT |
| Hook domain | 0 | DIRECT |
| 2'-5'-oligoadenylate synthetase 1, OAS1, second domain | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | DIRECT |
| RNB domain-like | 0 | DIRECT |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | DIRECT |
| 2Fe-2S ferredoxin domains from multidomain proteins | 0 | DIRECT |
| LON domain-like | 0 | DIRECT |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
| DNA ligase | 0 | DIRECT |
| Ribonuclease H | 0 | DIRECT |
| Methyl-CpG-binding domain, MBD | 0 | DIRECT |
| DEATH effector domain, DED | 0 | DIRECT |
| DNA gyrase/MutL, N-terminal domain | 0 | DIRECT |
| Ribosomal protein S10 | 0 | DIRECT |
| MAPEG domain | 0 | DIRECT |
| NagB-like | 0 | DIRECT |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain | 0 | DIRECT |
| PAS domain of steroid receptor coactivator 1A, NCo-A1 | 0 | DIRECT |
| Oligoxyloglucan reducing end-specific cellobiohydrolase | 0 | DIRECT |
| DLC | 0 | DIRECT |
| Mitochondrial cytochrome c oxidase subunit VIIa | 0 | DIRECT |
| P-domain of calnexin/calreticulin | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| 2'-5'-oligoadenylate synthetase 1, OAS1, N-terminal domain | 0 | DIRECT |
| GTF2I-like repeat | 0 | DIRECT |
| STAT | 0 | DIRECT |
| Enabled/VASP homology 1 domain (EVH1 domain) | 0 | DIRECT |
| Metallothionein | 0 | DIRECT |
| DEK C-terminal domain | 0 | DIRECT |
| Platelet-derived growth factor-like | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| a tRNA synthase domain | 0 | DIRECT |
| Troponin T | 0 | DIRECT |
| Fibrinogen coiled-coil and central regions | 0 | DIRECT |
| Tetrahydrofolate dehydrogenase/cyclohydrolase | 0 | DIRECT |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | DIRECT |
| Anaphylotoxins (complement system) | 0 | DIRECT |
| Proteasome activator | 0 | DIRECT |
| SelR domain | 0 | DIRECT |
| Trunk domain of Sec23/24 | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, C-terminal domain | 0 | DIRECT |
| Thyroglobulin type-1 domain | 0 | DIRECT |
| eIF1-like | 0 | DIRECT |
| ATP-dependent DNA ligase catalytic domain | 0 | DIRECT |
| CCHHC domain | 0 | DIRECT |
| Pointed domain | 0 | DIRECT |
| Starch-binding domain | 0 | DIRECT |
| HMA, heavy metal-associated domain | 0 | DIRECT |
| Transcription factor STAT-4 N-domain | 0 | DIRECT |
| beta-sandwich domain of Sec23/24 | 0 | DIRECT |
| Bcl-2 inhibitors of programmed cell death | 0 | DIRECT |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain | 0 | DIRECT |
| p53 DNA-binding domain-like | 0 | DIRECT |
| Occludin/ELL domain | 0 | DIRECT |
| Cysteine rich domain | 0 | DIRECT |
| Transferrin | 0 | DIRECT |
| La domain | 0 | DIRECT |
| HIN-200/IF120x domain | 0 | DIRECT |
| Adenylyltransferase | 0 | DIRECT |
| Osteonectin | 0 | DIRECT |
| AraD-like aldolase/epimerase | 0 | DIRECT |
| LanC-like | 0 | DIRECT |
| Cofactor-dependent phosphoglycerate mutase | 0 | DIRECT |
| Class I glutamine amidotransferases (GAT) | 0 | DIRECT |
| PUA domain | 0 | DIRECT |
| Protein serine/threonine phosphatase 2C, C-terminal domain | 0 | DIRECT |
| Retinoblastoma tumor suppressor domains | 0 | DIRECT |
| PurM C-terminal domain-like | 0 | DIRECT |
| Elongation factor TFIIS domain 2 | 0 | DIRECT |
| Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain | 0 | DIRECT |
| Phosphoribulokinase/pantothenate kinase | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Glycerol-3-phosphate transporter | 0 | DIRECT |
| PurM N-terminal domain-like | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Hexokinase | 0 | DIRECT |
| Calnexin/calreticulin | 0 | DIRECT |
| GHMP Kinase, N-terminal domain | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| N-terminal domain of cbl (N-cbl) | 0 | DIRECT |
| L-aspartase/fumarase | 0 | DIRECT |
| Variant SAM domain | 0 | DIRECT |
| Hsp90 middle domain | 0 | DIRECT |
| Nucleoplasmin-like core domain | 0 | DIRECT |
| Sec63 C-terminal domain-like | 0 | DIRECT |
| BSD domain | 0 | DIRECT |
| Steroid-binding domain | 0 | DIRECT |
| WGR domain | 0 | DIRECT |
| Surp module (SWAP domain) | 0 | DIRECT |
| Tissue inhibitor of metalloproteinases, TIMP | 0 | DIRECT |
| Ribosomal protein L18 and S11 | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| SH3BGR (SH3-binding, glutamic acid-rich protein-like) | 0 | DIRECT |
| Exostosin | 0 | DIRECT |
| Synuclein | 0 | DIRECT |
| A heparin-binding domain | 0 | DIRECT |
| SMAD domain | 0 | DIRECT |
| HD domain | 0 | DIRECT |
| STAT DNA-binding domain | 0 | DIRECT |
| Eferin C-derminal domain-like | 0 | DIRECT |
| C-terminal domain of PLC-beta | 0 | DIRECT |
| DNA ligase/mRNA capping enzyme postcatalytic domain | 0 | DIRECT |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | DIRECT |
| Class II glutamine amidotransferases | 0 | DIRECT |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
| BAG domain | 0 | DIRECT |
| DNA gyrase/MutL, second domain | 0 | DIRECT |
| C-terminal domain of adenylylcyclase associated protein | 0 | DIRECT |
| RGC domain | 0 | DIRECT |
| Cell cycle control phosphatase, catalytic domain | 0 | DIRECT |
| PAH2 domain | 0 | DIRECT |
| Cytochrome P450 | 0.00001145 | DIRECT |
| Pleckstrin-homology domain (PH domain) | 0.00005627 | DIRECT |
| SH2 domain | 0.0000676 | DIRECT |
| Calponin-homology domain, CH-domain | 0.0002007 | DIRECT |
| Leucine zipper domain | 0.0002955 | DIRECT |
| Nuclear receptor ligand-binding domain | 0.0003006 | DIRECT |
| EGF-type module | 0.0004809 | DIRECT |
| Nuclear receptor | 0.0005982 | DIRECT |
| DBL homology domain (DH-domain) | 0.001341 | INHERITED FROM: Antirheumatic Agents |
| SH3-domain | 0.001855 | INHERITED FROM: Antirheumatic Agents |
| Protein kinases, catalytic subunit | 0.002593 | INHERITED FROM: Protein Kinase Inhibitors || Fulvestrant || Contrast Media || Diagnostic Uses of Chemicals || Antineoplastic Agents || Hormones, Hormone Substitutes, and Hormone Antagonists |
| DEATH domain, DD | 0.004695 | INHERITED FROM: Gonadal Hormones || Hormones, Hormone Substitutes, and Hormone Antagonists |
| Plexin repeat | 0.005729 | INHERITED FROM: Gonadal Hormones || Estradiol || Hormones, Hormone Substitutes, and Hormone Antagonists |
| Caspase catalytic domain | 0.007391 | INHERITED FROM: Protease Inhibitors || Estradiol Congeners || Specialty Uses of Chemicals || Estradiol || 2-Methoxyestradiol || Peptide Hormones || Melatonin || Trypsin Inhibitors || Cysteine Proteinase Inhibitors |
| Short-chain cytokines | 0.007391 | INHERITED FROM: Cosmetics || Agglutinins || Coagulants || Hydrocortisone || 11-Hydroxycorticosteroids || Hematologic Agents || Specialty Uses of Chemicals || Adrenal Cortex Hormones || Perfume || 17-Hydroxycorticosteroids || Immunologic Factors |
| UBA domain | 0.009323 | INHERITED FROM: Enzyme Inhibitors || Molecular Mechanisms of Pharmacological Action |
| Interleukin 8-like chemokines | 0.01064 | INHERITED FROM: Cosmetics || Coagulants || Corpus Luteum Hormones || Hematologic Agents || Fludrocortisone || Specialty Uses of Chemicals || Therapeutic Uses || Progesterone Congeners || Perfume || Fulvestrant || 17-Hydroxycorticosteroids || Immunologic Factors |
| Integrin domains | 0.01303 | INHERITED FROM: Gonadal Hormones || Corpus Luteum Hormones || Medroxyprogesterone Acetate || Triiodothyronine || Progesterone Congeners || Thyronines || Progesterone || Medroxyprogesterone |
| Transforming growth factor (TGF)-beta | 0.01381 | INHERITED FROM: Hypothalamic Hormones || Somatostatin || Estradiol || Peptide Hormones || pasireotide || Progesterone || Hormones, Hormone Substitutes, and Hormone Antagonists |
| C1 set domains (antibody constant domain-like) | 0.01381 | INHERITED FROM: Protease Inhibitors || Antirheumatic Agents || Angiotensin-Converting Enzyme Inhibitors || Therapeutic Uses |
| Kringle modules | 0.01657 | INHERITED FROM: ethinyl estradiol-desogestrel combination || Medroxyprogesterone Acetate || Estradiol || Medroxyprogesterone |
| Histone deacetylase, HDAC | 0.01751 | INHERITED FROM: Gonadal Hormones || Estradiol Congeners || Estradiol || testosterone-3-carboxymethyloxime-bovine serum albumin conjugate || Physiological Effects of Drugs || Hormones, Hormone Substitutes, and Hormone Antagonists |
| Sema domain | 0.02065 | INHERITED FROM: Gonadal Hormones || Estradiol || Hormones, Hormone Substitutes, and Hormone Antagonists |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.02559 | INHERITED FROM: Enzyme Inhibitors |
| Integrin alpha N-terminal domain | 0.02559 | INHERITED FROM: Corpus Luteum Hormones || Progesterone Congeners || Progesterone |
| Cytochrome b5 | 0.02663 | INHERITED FROM: Progesterone |
| MIF4G domain-like | 0.02663 | INHERITED FROM: Enzyme Inhibitors |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.02663 | INHERITED FROM: Enzyme Inhibitors |
| Rel/Dorsal transcription factors, DNA-binding domain | 0.02663 | INHERITED FROM: Protein Kinase Inhibitors |
| ABC transporter ATPase domain-like | 0.02681 | INHERITED FROM: Central Nervous System Agents || estradiol-17 beta-glucuronide || Methyltestosterone || Toxic Actions || Anticonvulsants || Progesterone |
| Growth factor receptor domain | 0.02774 | INHERITED FROM: Gonadal Hormones || Medroxyprogesterone Acetate || Progesterone || Insulins || Antineoplastic Agents || Physiological Effects of Drugs || Hormones, Hormone Substitutes, and Hormone Antagonists |
| GLA-domain | 0.03447 | INHERITED FROM: ethinyl estradiol-desogestrel combination || Reproductive Control Agents || Estrogenic Steroids, Alkylated || Medroxyprogesterone Acetate || estradiol valerate-dienogest || norgestimate, ethinyl estradiol drug combination || dienogest || estradiol, norethindrone drug combination || Nandrolone || Medroxyprogesterone |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.04021 | INHERITED FROM: Enzyme Inhibitors |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.04283 | INHERITED FROM: Specialty Uses of Chemicals |
| Serpins | 0.04448 | INHERITED FROM: ethinyl estradiol-desogestrel combination || Gonadal Hormones || 11-Hydroxycorticosteroids || Estrogenic Steroids, Alkylated || Hormones, Hormone Substitutes, and Hormone Antagonists |
| ets domain | 0.04695 | INHERITED FROM: Nandrolone || mibolerone |
| Glutathione S-transferase (GST), C-terminal domain | 0.04695 | INHERITED FROM: 17-Ketosteroids || Androstenedione |
| MHC antigen-recognition domain | 0.0597 | INHERITED FROM: Protease Inhibitors || Antirheumatic Agents || Angiotensin-Converting Enzyme Inhibitors || Therapeutic Uses |
| VHP, Villin headpiece domain | 0.06001 | INHERITED FROM: Estradiol |
| Inhibitor of apoptosis (IAP) repeat | 0.06001 | INHERITED FROM: Gastrointestinal Hormones || Gastrins || Peptide Hormones |
| Integrin beta EGF-like domains | 0.06001 | INHERITED FROM: Estradiol || Progesterone |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0.06001 | INHERITED FROM: Testosterone || Testosterone Congeners |
| Integrin A (or I) domain | 0.06694 | INHERITED FROM: Corpus Luteum Hormones || Medroxyprogesterone Acetate || Triiodothyronine || Estradiol || Progesterone Congeners || Thyronines || Medroxyprogesterone |
| Hemopexin-like domain | 0.06985 | INHERITED FROM: Protease Inhibitors || Estradiol Congeners || Phospholipase A2 Inhibitors || Matrix Metalloproteinase Inhibitors || Estradiol || Progesterone |
| Matrix metalloproteases, catalytic domain | 0.06985 | INHERITED FROM: Protease Inhibitors || Gonadal Hormones || Phospholipase A2 Inhibitors || Matrix Metalloproteinase Inhibitors || Estradiol || Nandrolone || Progesterone || mibolerone || Physiological Effects of Drugs || Hormones, Hormone Substitutes, and Hormone Antagonists |
| MMP N-terminal domain | 0.07983 | INHERITED FROM: Protease Inhibitors || Estradiol Congeners || Phospholipase A2 Inhibitors || Matrix Metalloproteinase Inhibitors || Estradiol || Nandrolone || Progesterone || mibolerone |
| Caspase recruitment domain, CARD | 0.07983 | INHERITED FROM: Protease Inhibitors || Environmental Pollutants || Cysteine Proteinase Inhibitors |
| Integrin beta tail domain | 0.08882 | INHERITED FROM: Corpus Luteum Hormones || Progesterone Congeners || Progesterone |
| Gonadodropin/Follitropin | 0.09602 | INHERITED FROM: Estradiol Congeners || Hypothalamic Hormones || Estradiol || Peptide Hormones || Gonadotropin-Releasing Hormone || Pituitary Hormone-Releasing Hormones |
| Myb/SANT domain | 0.09799 | INHERITED FROM: Triiodothyronine || Fulvestrant || Thyronines |
| Eukaryotic type KH-domain (KH-domain type I) | 0.1171 | INHERITED FROM: Enzyme Inhibitors || Molecular Mechanisms of Pharmacological Action |
| Cofilin-like | 0.1319 | INHERITED FROM: Enzyme Inhibitors || Molecular Mechanisms of Pharmacological Action |
| Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain | 0.1319 | INHERITED FROM: Antirheumatic Agents || Therapeutic Uses |
| S100 proteins | 0.1352 | INHERITED FROM: Cosmetics || Perfume |
| Ovomucoid domain III-like | 0.1376 | INHERITED FROM: 3-iodothyronamine || Thyronines || estrone sulfate |
| UDPGT-like | 0.1457 | INHERITED FROM: Estrogens, Catechol || Hydroxyestrones || 4-hydroxyestrone || Pregnenolone Carbonitrile || 2-Methoxyestradiol || Pregnenolone || Adrenal Cortex Hormones || Estriol || 2-hydroxyestradiol || Androsterone || Estrone |
| ABC transporter transmembrane region | 0.1528 | INHERITED FROM: Central Nervous System Agents || estradiol-17 beta-glucuronide || Methyltestosterone || Peptide Hormones || Anticonvulsants || Progesterone |
| Long-chain cytokines | 0.157 | INHERITED FROM: Corpus Luteum Hormones || Progesterone Congeners || 17-Ketosteroids || Peptide Hormones || Progesterone |
| Cyclin | 0.1611 | INHERITED FROM: 2-Methoxyestradiol || Fulvestrant |
| A DNA-binding domain in eukaryotic transcription factors | 0.1726 | INHERITED FROM: Agrochemicals |
| C2 set domains | 0.179 | INHERITED FROM: Antirheumatic Agents || Hydrocortisone || 11-Hydroxycorticosteroids || Estrogenic Steroids, Alkylated || Hydroxycorticosteroids || Therapeutic Uses || Adrenal Cortex Hormones || 17-Hydroxycorticosteroids |
| Phosphate binding protein-like | 0.1823 | INHERITED FROM: Neurotransmitter Agents || Excitatory Amino Acid Agents || Excitatory Amino Acid Agonists |
| Multidomain cupredoxins | 0.1891 | INHERITED FROM: ethinyl estradiol-desogestrel combination || Estrogenic Steroids, Alkylated |
| Fibronectin type II module | 0.2039 | INHERITED FROM: Protease Inhibitors || Medroxyprogesterone Acetate || Angiotensin-Converting Enzyme Inhibitors || Medroxyprogesterone |
| Canonical RBD | 0.2086 | INHERITED FROM: Enzyme Inhibitors || Molecular Mechanisms of Pharmacological Action |
| Ubiquitin-related | 0.2106 | INHERITED FROM: Enzyme Inhibitors |
| Double-stranded RNA-binding domain (dsRBD) | 0.2259 | INHERITED FROM: Enzyme Inhibitors || Molecular Mechanisms of Pharmacological Action |
| PAPS sulfotransferase | 0.2318 | INHERITED FROM: Dehydroepiandrosterone || Adrenal Cortex Hormones || 17-Ketosteroids || 2-hydroxyestradiol || Estrone |
| Tyrosine-dependent oxidoreductases | 0.2389 | INHERITED FROM: Glucocorticoids || Dehydroepiandrosterone || Cortisone || Adrenal Cortex Hormones || Androstenedione || Androstenediol || Estrone |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.2402 | INHERITED FROM: Enzyme Inhibitors || Molecular Mechanisms of Pharmacological Action |
| Tandem AAA-ATPase domain | 0.2577 | INHERITED FROM: Enzyme Inhibitors |
| Cell cycle transcription factor e2f-dp | 0.2624 | INHERITED FROM: Testosterone |
| PreBEACH PH-like domain | 0.2724 | INHERITED FROM: Environmental Pollutants || Toxic Actions || Air Pollutants |
| Aldo-keto reductases (NADP) | 0.2767 | INHERITED FROM: 5-alpha-Dihydroprogesterone || 11-Hydroxycorticosteroids || Medroxyprogesterone Acetate || Triiodothyronine || Corticosterone || 20-alpha-Dihydroprogesterone || Adrenal Cortex Hormones || 4-hydroxyequilenin-o-quinone || Thyronines || Equilenin || Desoxycorticosterone || tetrahydrodeoxycorticosterone || Thyroxine || Estrone || Medroxyprogesterone || 16-ketoestrone |
| Scavenger receptor cysteine-rich (SRCR) domain | 0.2767 | INHERITED FROM: Medroxyprogesterone Acetate || Medroxyprogesterone |
| Acyl-CoA binding protein | 0.3173 | INHERITED FROM: Testosterone Congeners |
| SNF-like | 0.3313 | INHERITED FROM: Specialty Uses of Chemicals || Fluorescent Dyes || Coloring Agents |
| Hormone receptor domain | 0.3313 | INHERITED FROM: Peptide Hormones || Pituitary Hormone-Releasing Hormones |
| Insulin-like | 0.3314 | INHERITED FROM: Hypothalamic Hormones || Hydrocortisone || 11-Hydroxycorticosteroids || Hydroxycorticosteroids || Peptide Hormones || Testosterone || Testosterone Congeners || 17-Hydroxycorticosteroids |
| Pentraxin (pentaxin) | 0.3314 | INHERITED FROM: Medroxyprogesterone Acetate || Medroxyprogesterone |
| SAP domain | 0.3738 | INHERITED FROM: Enzyme Inhibitors || Molecular Mechanisms of Pharmacological Action |
| Blood coagulation inhibitor (disintegrin) | 0.3828 | INHERITED FROM: Triiodothyronine || Thyronines || Thyroxine |
| VWC domain | 0.392 | INHERITED FROM: testosterone enanthate || Estrogenic Steroids, Alkylated |
| Group II chaperonin (CCT, TRIC), apical domain | 0.4088 | INHERITED FROM: Enzyme Inhibitors || Molecular Mechanisms of Pharmacological Action |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0.4911 | INHERITED FROM: Enzyme Inhibitors || Molecular Mechanisms of Pharmacological Action |
| Interferons/interleukin-10 (IL-10) | 0.5328 | INHERITED FROM: Cosmetics || Hydrocortisone || Perfume || Protein Kinase Inhibitors || 17-Hydroxycorticosteroids |
| V set domains (antibody variable domain-like) | 0.5448 | INHERITED FROM: Adjuvants, Immunologic |
| Interleukin-1 (IL-1) | 0.5798 | INHERITED FROM: Hydrocortisone || 11-Hydroxycorticosteroids || Hydroxycorticosteroids || Adrenal Cortex Hormones || 17-Hydroxycorticosteroids |
| R3H domain | 0.5798 | INHERITED FROM: Enzyme Inhibitors || Molecular Mechanisms of Pharmacological Action |
| Armadillo repeat | 0.6324 | INHERITED FROM: Enzyme Inhibitors || Molecular Mechanisms of Pharmacological Action |
| Proteasome subunits | 0.6886 | INHERITED FROM: Environmental Pollutants || Toxic Actions |
| Cold shock DNA-binding domain-like | 0.7247 | INHERITED FROM: Enzyme Inhibitors || Molecular Mechanisms of Pharmacological Action |
| TNF-like | 0.7279 | INHERITED FROM: Medroxyprogesterone Acetate || Hydroxyprogesterones |
| L-arabinose binding protein-like | 0.7495 | INHERITED FROM: Neurotransmitter Agents || Excitatory Amino Acid Agents || Excitatory Amino Acid Agonists |
| N-acetyl transferase, NAT | 0.8417 | INHERITED FROM: testosterone-3-carboxymethyloxime-bovine serum albumin conjugate |
| Nucleosome core histones | 0.8885 | INHERITED FROM: Environmental Pollutants || Toxic Actions || Air Pollutants |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.9342 | INHERITED FROM: Flame Retardants || Neurotransmitter Agents || GABA Agents |
| HLH, helix-loop-helix DNA-binding domain | 0.9361 | INHERITED FROM: Dihydrotestosterone || testosterone-3-carboxymethyloxime-bovine serum albumin conjugate |
| Nicotinic receptor ligand binding domain-like | 0.9587 | INHERITED FROM: Flame Retardants || Neurotransmitter Agents || GABA Agents |
| Fibrinogen C-terminal domain-like | 0.9697 | INHERITED FROM: ethinyl estradiol-desogestrel combination || estradiol valerate-dienogest || dienogest || Nandrolone |
| Rhodopsin-like | 1 | INHERITED FROM: Somatostatin || Pituitary Hormone Release Inhibiting Hormones |
| Eukaryotic proteases | 1 | INHERITED FROM: Protease Inhibitors || ethinyl estradiol-desogestrel combination || Reproductive Control Agents || Medroxyprogesterone Acetate || NuvaRing || estradiol valerate-dienogest || estradiol, norethindrone drug combination || Nandrolone || Medroxyprogesterone |
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Protein-L-isoaspartyl O-methyltransferase | 0 | Direct |
| Netrin-like domain (NTR/C345C module) | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| Diap1 N-terninal region-like | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | Direct |
| Formate/glycerate dehydrogenases, substrate-binding domain | 0 | Direct |
| p53 tetramerization domain | 0 | Direct |
| FAD-dependent thiol oxidase | 0 | Direct |
| Alkaline phosphatase | 0 | Direct |
| L domain | 0 | Direct |
| Domain of poly(ADP-ribose) polymerase | 0 | Direct |
| IP3 receptor type 1 binding core, domain 2 | 0 | Direct |
| Hook domain | 0 | Direct |
| 2'-5'-oligoadenylate synthetase 1, OAS1, second domain | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | Direct |
| RNB domain-like | 0 | Direct |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | Direct |
| 2Fe-2S ferredoxin domains from multidomain proteins | 0 | Direct |
| LON domain-like | 0 | Direct |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
| DNA ligase | 0 | Direct |
| Ribonuclease H | 0 | Direct |
| Methyl-CpG-binding domain, MBD | 0 | Direct |
| DEATH effector domain, DED | 0 | Direct |
| DNA gyrase/MutL, N-terminal domain | 0 | Direct |
| Ribosomal protein S10 | 0 | Direct |
| MAPEG domain | 0 | Direct |
| NagB-like | 0 | Direct |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain | 0 | Direct |
| PAS domain of steroid receptor coactivator 1A, NCo-A1 | 0 | Direct |
| Oligoxyloglucan reducing end-specific cellobiohydrolase | 0 | Direct |
| DLC | 0 | Direct |
| Mitochondrial cytochrome c oxidase subunit VIIa | 0 | Direct |
| P-domain of calnexin/calreticulin | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| 2'-5'-oligoadenylate synthetase 1, OAS1, N-terminal domain | 0 | Direct |
| GTF2I-like repeat | 0 | Direct |
| STAT | 0 | Direct |
| Enabled/VASP homology 1 domain (EVH1 domain) | 0 | Direct |
| Metallothionein | 0 | Direct |
| DEK C-terminal domain | 0 | Direct |
| Platelet-derived growth factor-like | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| a tRNA synthase domain | 0 | Direct |
| Troponin T | 0 | Direct |
| Fibrinogen coiled-coil and central regions | 0 | Direct |
| Tetrahydrofolate dehydrogenase/cyclohydrolase | 0 | Direct |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | Direct |
| Anaphylotoxins (complement system) | 0 | Direct |
| Proteasome activator | 0 | Direct |
| SelR domain | 0 | Direct |
| Trunk domain of Sec23/24 | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, C-terminal domain | 0 | Direct |
| Thyroglobulin type-1 domain | 0 | Direct |
| eIF1-like | 0 | Direct |
| ATP-dependent DNA ligase catalytic domain | 0 | Direct |
| CCHHC domain | 0 | Direct |
| Pointed domain | 0 | Direct |
| Starch-binding domain | 0 | Direct |
| HMA, heavy metal-associated domain | 0 | Direct |
| Transcription factor STAT-4 N-domain | 0 | Direct |
| beta-sandwich domain of Sec23/24 | 0 | Direct |
| Bcl-2 inhibitors of programmed cell death | 0 | Direct |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain | 0 | Direct |
| p53 DNA-binding domain-like | 0 | Direct |
| Occludin/ELL domain | 0 | Direct |
| Cysteine rich domain | 0 | Direct |
| Transferrin | 0 | Direct |
| La domain | 0 | Direct |
| HIN-200/IF120x domain | 0 | Direct |
| Adenylyltransferase | 0 | Direct |
| Osteonectin | 0 | Direct |
| AraD-like aldolase/epimerase | 0 | Direct |
| LanC-like | 0 | Direct |
| Cofactor-dependent phosphoglycerate mutase | 0 | Direct |
| Class I glutamine amidotransferases (GAT) | 0 | Direct |
| PUA domain | 0 | Direct |
| Protein serine/threonine phosphatase 2C, C-terminal domain | 0 | Direct |
| Retinoblastoma tumor suppressor domains | 0 | Direct |
| PurM C-terminal domain-like | 0 | Direct |
| Elongation factor TFIIS domain 2 | 0 | Direct |
| Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain | 0 | Direct |
| Phosphoribulokinase/pantothenate kinase | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Glycerol-3-phosphate transporter | 0 | Direct |
| PurM N-terminal domain-like | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| Hexokinase | 0 | Direct |
| Calnexin/calreticulin | 0 | Direct |
| GHMP Kinase, N-terminal domain | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| N-terminal domain of cbl (N-cbl) | 0 | Direct |
| L-aspartase/fumarase | 0 | Direct |
| Variant SAM domain | 0 | Direct |
| Hsp90 middle domain | 0 | Direct |
| Nucleoplasmin-like core domain | 0 | Direct |
| Sec63 C-terminal domain-like | 0 | Direct |
| BSD domain | 0 | Direct |
| Steroid-binding domain | 0 | Direct |
| WGR domain | 0 | Direct |
| Surp module (SWAP domain) | 0 | Direct |
| Tissue inhibitor of metalloproteinases, TIMP | 0 | Direct |
| Ribosomal protein L18 and S11 | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| SH3BGR (SH3-binding, glutamic acid-rich protein-like) | 0 | Direct |
| Exostosin | 0 | Direct |
| Synuclein | 0 | Direct |
| A heparin-binding domain | 0 | Direct |
| SMAD domain | 0 | Direct |
| HD domain | 0 | Direct |
| STAT DNA-binding domain | 0 | Direct |
| Eferin C-derminal domain-like | 0 | Direct |
| C-terminal domain of PLC-beta | 0 | Direct |
| DNA ligase/mRNA capping enzyme postcatalytic domain | 0 | Direct |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | Direct |
| Class II glutamine amidotransferases | 0 | Direct |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
| BAG domain | 0 | Direct |
| DNA gyrase/MutL, second domain | 0 | Direct |
| C-terminal domain of adenylylcyclase associated protein | 0 | Direct |
| RGC domain | 0 | Direct |
| Cell cycle control phosphatase, catalytic domain | 0 | Direct |
| PAH2 domain | 0 | Direct |
| Cytochrome P450 | 0.00001145 | Direct |
| Pleckstrin-homology domain (PH domain) | 0.00005627 | Direct |
| SH2 domain | 0.0000676 | Direct |
| Calponin-homology domain, CH-domain | 0.0002007 | Direct |
| Leucine zipper domain | 0.0002955 | Direct |
| Nuclear receptor ligand-binding domain | 0.0003006 | Direct |
| EGF-type module | 0.0004809 | Direct |
| Nuclear receptor | 0.0005982 | Direct |
| DBL homology domain (DH-domain) | 0.001341 | Inherited |
| SH3-domain | 0.001855 | Inherited |
| Protein kinases, catalytic subunit | 0.002593 | Inherited |
| DEATH domain, DD | 0.004695 | Inherited |
| Plexin repeat | 0.005729 | Inherited |
| Caspase catalytic domain | 0.007391 | Inherited |
| Short-chain cytokines | 0.007391 | Inherited |
| UBA domain | 0.009323 | Inherited |
| Interleukin 8-like chemokines | 0.01064 | Inherited |
| Integrin domains | 0.01303 | Inherited |
| Transforming growth factor (TGF)-beta | 0.01381 | Inherited |
| C1 set domains (antibody constant domain-like) | 0.01381 | Inherited |
| Kringle modules | 0.01657 | Inherited |
| Histone deacetylase, HDAC | 0.01751 | Inherited |
| Sema domain | 0.02065 | Inherited |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.02559 | Inherited |
| Integrin alpha N-terminal domain | 0.02559 | Inherited |
| Cytochrome b5 | 0.02663 | Inherited |
| MIF4G domain-like | 0.02663 | Inherited |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.02663 | Inherited |
| Rel/Dorsal transcription factors, DNA-binding domain | 0.02663 | Inherited |
| ABC transporter ATPase domain-like | 0.02681 | Inherited |
| Growth factor receptor domain | 0.02774 | Inherited |
| GLA-domain | 0.03447 | Inherited |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.04021 | Inherited |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.04283 | Inherited |
| Serpins | 0.04448 | Inherited |
| ets domain | 0.04695 | Inherited |
| Glutathione S-transferase (GST), C-terminal domain | 0.04695 | Inherited |
| MHC antigen-recognition domain | 0.0597 | Inherited |
| VHP, Villin headpiece domain | 0.06001 | Inherited |
| Inhibitor of apoptosis (IAP) repeat | 0.06001 | Inherited |
| Integrin beta EGF-like domains | 0.06001 | Inherited |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0.06001 | Inherited |
| Integrin A (or I) domain | 0.06694 | Inherited |
| Hemopexin-like domain | 0.06985 | Inherited |
| Matrix metalloproteases, catalytic domain | 0.06985 | Inherited |
| MMP N-terminal domain | 0.07983 | Inherited |
| Caspase recruitment domain, CARD | 0.07983 | Inherited |
| Integrin beta tail domain | 0.08882 | Inherited |
| Gonadodropin/Follitropin | 0.09602 | Inherited |
| Myb/SANT domain | 0.09799 | Inherited |
| Eukaryotic type KH-domain (KH-domain type I) | 0.1171 | Inherited |
| Cofilin-like | 0.1319 | Inherited |
| Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain | 0.1319 | Inherited |
| S100 proteins | 0.1352 | Inherited |
| Ovomucoid domain III-like | 0.1376 | Inherited |
| UDPGT-like | 0.1457 | Inherited |
| ABC transporter transmembrane region | 0.1528 | Inherited |
| Long-chain cytokines | 0.157 | Inherited |
| Cyclin | 0.1611 | Inherited |
| A DNA-binding domain in eukaryotic transcription factors | 0.1726 | Inherited |
| C2 set domains | 0.179 | Inherited |
| Phosphate binding protein-like | 0.1823 | Inherited |
| Multidomain cupredoxins | 0.1891 | Inherited |
| Fibronectin type II module | 0.2039 | Inherited |
| Canonical RBD | 0.2086 | Inherited |
| Ubiquitin-related | 0.2106 | Inherited |
| Double-stranded RNA-binding domain (dsRBD) | 0.2259 | Inherited |
| PAPS sulfotransferase | 0.2318 | Inherited |
| Tyrosine-dependent oxidoreductases | 0.2389 | Inherited |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.2402 | Inherited |
| Tandem AAA-ATPase domain | 0.2577 | Inherited |
| Cell cycle transcription factor e2f-dp | 0.2624 | Inherited |
| PreBEACH PH-like domain | 0.2724 | Inherited |
| Aldo-keto reductases (NADP) | 0.2767 | Inherited |
| Scavenger receptor cysteine-rich (SRCR) domain | 0.2767 | Inherited |
| Acyl-CoA binding protein | 0.3173 | Inherited |
| SNF-like | 0.3313 | Inherited |
| Hormone receptor domain | 0.3313 | Inherited |
| Insulin-like | 0.3314 | Inherited |
| Pentraxin (pentaxin) | 0.3314 | Inherited |
| SAP domain | 0.3738 | Inherited |
| Blood coagulation inhibitor (disintegrin) | 0.3828 | Inherited |
| VWC domain | 0.392 | Inherited |
| Group II chaperonin (CCT, TRIC), apical domain | 0.4088 | Inherited |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0.4911 | Inherited |
| Interferons/interleukin-10 (IL-10) | 0.5328 | Inherited |
| V set domains (antibody variable domain-like) | 0.5448 | Inherited |
| Interleukin-1 (IL-1) | 0.5798 | Inherited |
| R3H domain | 0.5798 | Inherited |
| Armadillo repeat | 0.6324 | Inherited |
| Proteasome subunits | 0.6886 | Inherited |
| Cold shock DNA-binding domain-like | 0.7247 | Inherited |
| TNF-like | 0.7279 | Inherited |
| L-arabinose binding protein-like | 0.7495 | Inherited |
| N-acetyl transferase, NAT | 0.8417 | Inherited |
| Nucleosome core histones | 0.8885 | Inherited |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.9342 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.9361 | Inherited |
| Nicotinic receptor ligand binding domain-like | 0.9587 | Inherited |
| Fibrinogen C-terminal domain-like | 0.9697 | Inherited |
| Rhodopsin-like | 1 | Inherited |
| Eukaryotic proteases | 1 | Inherited |
LINKTO: Domain2BO Download and Domain2BO Algorithm
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Supra-domain (Single)( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Ribosomal protein L30p/L7e | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | DIRECT |
| Hook domain | 0 | DIRECT |
| P-domain of calnexin/calreticulin | 0 | DIRECT |
| STAT | 0 | DIRECT |
| Thyroglobulin type-1 domain | 0 | DIRECT |
| AhpD-like | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| Metallothionein | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Nucleoporin domain | 0 | DIRECT |
| FAD-dependent thiol oxidase | 0 | DIRECT |
| LanC-like | 0 | DIRECT |
| PurM N-terminal domain-like | 0 | DIRECT |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
| WGR domain-like | 0 | DIRECT |
| Surp module (SWAP domain) | 0 | DIRECT |
| ATP-dependent DNA ligase DNA-binding domain | 0 | DIRECT |
| BSD domain-like | 0 | DIRECT |
| Protein serine/threonine phosphatase 2C, C-terminal domain | 0 | DIRECT |
| G protein-binding domain | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| L-aspartase-like | 0 | DIRECT |
| AraD/HMP-PK domain-like | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
| Phosphoenolpyruvate/pyruvate domain | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| Mitochondrial cytochrome c oxidase subunit VIIa | 0 | DIRECT |
| MgtE membrane domain-like | 0 | DIRECT |
| GHMP Kinase, C-terminal domain | 0 | DIRECT |
| Transcription factor STAT-4 N-domain | 0 | DIRECT |
| eIF1-like | 0 | DIRECT |
| HMA, heavy metal-associated domain | 0 | DIRECT |
| PurM C-terminal domain-like | 0 | DIRECT |
| 3-carboxy-cis,cis-mucoante lactonizing enzyme | 0 | DIRECT |
| beta-lactamase/transpeptidase-like | 0 | DIRECT |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| Bcl-2 inhibitors of programmed cell death | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| DLC | 0 | DIRECT |
| Fibrinogen coiled-coil and central regions | 0 | DIRECT |
| A heparin-binding domain | 0 | DIRECT |
| GTF2I-like repeat | 0 | DIRECT |
| N-terminal domain of cbl (N-cbl) | 0 | DIRECT |
| Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
| ITPase-like | 0 | DIRECT |
| PAH2 domain | 0 | DIRECT |
| Indolic compounds 2,3-dioxygenase-like | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Nucleoplasmin-like core domain | 0 | DIRECT |
| Proteasome activator | 0 | DIRECT |
| Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain | 0 | DIRECT |
| BAG domain | 0 | DIRECT |
| EPT/RTPC-like | 0 | DIRECT |
| Nicotinate/Quinolinate PRTase C-terminal domain-like | 0 | DIRECT |
| RNase III domain-like | 0 | DIRECT |
| Anaphylotoxins (complement system) | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| HIN-2000 domain-like | 0 | DIRECT |
| Synuclein | 0 | DIRECT |
| CCHHC domain | 0 | DIRECT |
| Eferin C-derminal domain-like | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | DIRECT |
| RGC domain-like | 0 | DIRECT |
| Ribosomal protein L10-like | 0 | DIRECT |
| DEK C-terminal domain | 0 | DIRECT |
| MAPEG domain-like | 0 | DIRECT |
| Ribosomal protein S10 | 0 | DIRECT |
| C-terminal domain of PLC-beta | 0 | DIRECT |
| occludin/ELL-like | 0 | DIRECT |
| PH domain-like | 0.000000007355 | DIRECT |
| Cytochrome P450 | 0.000002984 | DIRECT |
| SH2 domain | 0.0000224 | DIRECT |
| Calponin-homology domain, CH-domain | 0.00008315 | DIRECT |
| Leucine zipper domain | 0.0001371 | DIRECT |
| Nuclear receptor ligand-binding domain | 0.0001424 | DIRECT |
| EGF/Laminin | 0.0002257 | DIRECT |
| SH3-domain | 0.0004182 | DIRECT |
| GTPase activation domain, GAP | 0.0004916 | DIRECT |
| Protein kinase-like (PK-like) | 0.0005457 | DIRECT |
| BRCT domain | 0.0005826 | DIRECT |
| DBL homology domain (DH-domain) | 0.0006323 | DIRECT |
| Growth factor receptor domain | 0.001059 | INHERITED FROM: Gonadal Hormones || Insulins || Physiological Effects of Drugs || 17-Hydroxycorticosteroids || Medroxyprogesterone || Antineoplastic Agents || Hormones, Hormone Substitutes, and Hormone Antagonists || Medroxyprogesterone Acetate |
| P-loop containing nucleoside triphosphate hydrolases | 0.001248 | INHERITED FROM: Anticonvulsants || estradiol-17 beta-glucuronide |
| DEATH domain | 0.001411 | INHERITED FROM: Air Pollutants, Occupational || Gonadal Hormones || Cysteine Proteinase Inhibitors || Gastrointestinal Hormones || gastrin 17 || Protease Inhibitors || Hormones, Hormone Substitutes, and Hormone Antagonists |
| Fibronectin type III | 0.001514 | INHERITED FROM: Hormones, Hormone Substitutes, and Hormone Antagonists |
| Caspase-like | 0.001979 | INHERITED FROM: Gonadal Hormones || Cysteine Proteinase Inhibitors || Specialty Uses of Chemicals || 2-Methoxyestradiol || Melatonin || Protease Inhibitors || Peptide Hormones || Estradiol || Hormones, Hormone Substitutes, and Hormone Antagonists || Enzyme Inhibitors || Trypsin Inhibitors |
| Cytochrome b5-like heme/steroid binding domain | 0.003183 | INHERITED FROM: Gonadal Hormones || Progesterone || Hormones, Hormone Substitutes, and Hormone Antagonists |
| Plexin repeat | 0.003363 | INHERITED FROM: Gonadal Hormones || Estradiol || Hormones, Hormone Substitutes, and Hormone Antagonists |
| Kringle-like | 0.006021 | INHERITED FROM: ethinyl estradiol-desogestrel combination || 11-Hydroxycorticosteroids || Progesterone || 17-Hydroxycorticosteroids || Medroxyprogesterone || Protease Inhibitors || Hydroxyprogesterones || Medroxyprogesterone Acetate |
| Interleukin 8-like chemokines | 0.006401 | INHERITED FROM: Fulvestrant || 11-Hydroxycorticosteroids || Specialty Uses of Chemicals || Progesterone Congeners || Immunologic Factors || Coagulants || 17-Hydroxycorticosteroids || Perfume || Hematologic Agents || Fludrocortisone || Corpus Luteum Hormones || Therapeutic Uses || Cosmetics |
| Nucleotidylyl transferase | 0.008045 | INHERITED FROM: Enzyme Inhibitors |
| p53-like transcription factors | 0.00854 | INHERITED FROM: Gastrointestinal Hormones || cetrorelix || Peptide Hormones || Gastrins || Pituitary Hormone-Releasing Hormones |
| Integrin domains | 0.008593 | INHERITED FROM: Gonadal Hormones || Progesterone || Progesterone Congeners || Thyronines || Triiodothyronine || Medroxyprogesterone || Corpus Luteum Hormones || Hormones, Hormone Substitutes, and Hormone Antagonists || Medroxyprogesterone Acetate |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0.008651 | INHERITED FROM: Estradiol |
| Cystine-knot cytokines | 0.01107 | INHERITED FROM: Androgens || Hypothalamic Hormones || Specialty Uses of Chemicals || Progesterone || Physiological Effects of Drugs || Peptide Hormones || pasireotide || Estradiol || Somatostatin || Hormones, Hormone Substitutes, and Hormone Antagonists || Medroxyprogesterone Acetate || Gonadotropin-Releasing Hormone |
| FAD/NAD(P)-binding domain | 0.01188 | INHERITED FROM: Toxic Actions |
| Sema domain | 0.01367 | INHERITED FROM: Gonadal Hormones || Estradiol || Hormones, Hormone Substitutes, and Hormone Antagonists |
| Immunoglobulin | 0.01454 | INHERITED FROM: Protein Kinase Inhibitors || Therapeutic Uses |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.01573 | INHERITED FROM: Hormone Antagonists || Specialty Uses of Chemicals || Goserelin || Soil Pollutants || tetraiodothyroacetic acid || Equilin || Pesticides || 5-alpha-Dihydroprogesterone || Cortodoxone || Water Pollutants, Chemical || Invertebrate Hormones || 3,3',5-triiodothyroacetic acid || Corticosterone || Juvenile Hormones || Estriol |
| Complement control module/SCR domain | 0.01585 | INHERITED FROM: Perfume |
| C-terminal, gelsolin-like domain of Sec23/24 | 0.01991 | INHERITED FROM: Dihydrotestosterone || Enzyme Inhibitors |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.01991 | INHERITED FROM: Enzyme Inhibitors |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.01991 | INHERITED FROM: Enzyme Inhibitors |
| Serpins | 0.02343 | INHERITED FROM: Gonadal Hormones || ethinyl estradiol-desogestrel combination || 11-Hydroxycorticosteroids || Physiological Effects of Drugs || Estrogenic Steroids, Alkylated || Hormones, Hormone Substitutes, and Hormone Antagonists |
| Rhodanese/Cell cycle control phosphatase | 0.0239 | INHERITED FROM: Toxic Actions || Environmental Pollutants |
| GST C-terminal domain-like | 0.02539 | INHERITED FROM: Molecular Mechanisms of Pharmacological Action || Androstenedione || 17-Ketosteroids || Enzyme Inhibitors |
| Arginase/deacetylase | 0.02548 | INHERITED FROM: Gonadal Hormones || Physiological Effects of Drugs || Estradiol Congeners || Estradiol || Hormones, Hormone Substitutes, and Hormone Antagonists |
| GLA-domain | 0.02548 | INHERITED FROM: ethinyl estradiol-desogestrel combination || estradiol, norethindrone drug combination || estradiol valerate-dienogest || norgestimate, ethinyl estradiol drug combination || Estrogenic Steroids, Alkylated || Medroxyprogesterone || Nandrolone || Reproductive Control Agents || Medroxyprogesterone Acetate || dienogest |
| 4-helical cytokines | 0.03122 | INHERITED FROM: Dehydroepiandrosterone || Nitric Oxide Donors || Agglutinins || Pituitary Hormones, Anterior || Cardiovascular Agents || 11-Hydroxycorticosteroids || Specialty Uses of Chemicals || Protein Kinase Inhibitors || Progesterone Congeners || Immunologic Factors || Coagulants || 17-Hydroxycorticosteroids || Perfume || Hematologic Agents || Medroxyprogesterone || Peptide Hormones || Corpus Luteum Hormones || Estrogens, Conjugated (USP) || Medroxyprogesterone Acetate || Adrenal Cortex Hormones || Hydrocortisone || Cosmetics |
| NAD(P)-binding Rossmann-fold domains | 0.03606 | INHERITED FROM: Cortisone || Androstenediol || Androstenedione || Estrone || Hormones, Hormone Substitutes, and Hormone Antagonists || Adrenal Cortex Hormones |
| Ribosomal protein S5 domain 2-like | 0.03947 | INHERITED FROM: Enzyme Inhibitors |
| MHC antigen-recognition domain | 0.04176 | INHERITED FROM: Protease Inhibitors || Angiotensin-Converting Enzyme Inhibitors || Therapeutic Uses || Antirheumatic Agents |
| dsRNA-binding domain-like | 0.04371 | INHERITED FROM: Molecular Mechanisms of Pharmacological Action || Enzyme Inhibitors |
| VHP, Villin headpiece domain | 0.04724 | INHERITED FROM: Estradiol Congeners || Estradiol |
| Inhibitor of apoptosis (IAP) repeat | 0.04724 | INHERITED FROM: Gastrointestinal Hormones || Peptide Hormones || Gastrins |
| Integrin alpha N-terminal domain | 0.05174 | INHERITED FROM: Progesterone || Progesterone Congeners || Corpus Luteum Hormones |
| Hemopexin-like domain | 0.05174 | INHERITED FROM: Matrix Metalloproteinase Inhibitors || Progesterone || Estradiol Congeners || Protease Inhibitors || Phospholipase A2 Inhibitors || Estradiol |
| PGBD-like | 0.06078 | INHERITED FROM: Gonadal Hormones || Matrix Metalloproteinase Inhibitors || Progesterone || Physiological Effects of Drugs || Estradiol Congeners || Protease Inhibitors || Phospholipase A2 Inhibitors || Nandrolone || mibolerone || Estradiol || Hormones, Hormone Substitutes, and Hormone Antagonists |
| Metalloproteases ("zincins"), catalytic domain | 0.06299 | INHERITED FROM: Matrix Metalloproteinase Inhibitors || Progesterone || Protease Inhibitors || Phospholipase A2 Inhibitors || mibolerone |
| Periplasmic binding protein-like II | 0.06817 | INHERITED FROM: Excitatory Amino Acid Agonists || Excitatory Amino Acid Agents || Neurotransmitter Agents |
| Integrin beta tail domain | 0.0718 | INHERITED FROM: Progesterone || Progesterone Congeners || Corpus Luteum Hormones |
| S15/NS1 RNA-binding domain | 0.0718 | INHERITED FROM: Molecular Mechanisms of Pharmacological Action || Enzyme Inhibitors |
| Eukaryotic type KH-domain (KH-domain type I) | 0.1025 | INHERITED FROM: Molecular Mechanisms of Pharmacological Action || Enzyme Inhibitors |
| Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain | 0.1072 | INHERITED FROM: Therapeutic Uses || Antirheumatic Agents |
| post-AAA+ oligomerization domain-like | 0.108 | INHERITED FROM: Enzyme Inhibitors |
| MFS general substrate transporter | 0.1153 | INHERITED FROM: Thyroxine || Dehydroepiandrosterone || estrone sulfate || 3-iodothyronamine || Thyroid Hormones || Physiological Effects of Drugs || Thyronines || Estrone || estradiol-17 beta-glucuronide || Dehydroepiandrosterone Sulfate || Hormones, Hormone Substitutes, and Hormone Antagonists || Adrenal Cortex Hormones |
| FnI-like domain | 0.1255 | INHERITED FROM: Angiotensins || Estrogenic Steroids, Alkylated || Peptide Hormones |
| A DNA-binding domain in eukaryotic transcription factors | 0.1392 | INHERITED FROM: Agrochemicals |
| Cupredoxins | 0.1463 | INHERITED FROM: ethinyl estradiol-desogestrel combination |
| SPOC domain-like | 0.1604 | INHERITED FROM: Molecular Mechanisms of Pharmacological Action || Enzyme Inhibitors |
| Kazal-type serine protease inhibitors | 0.1632 | INHERITED FROM: estrone sulfate || 3-iodothyronamine || Thyroid Hormones || Thyronines |
| beta-sandwich domain of Sec23/24 | 0.1688 | INHERITED FROM: Dihydrotestosterone || Molecular Mechanisms of Pharmacological Action || Testosterone Congeners || Enzyme Inhibitors |
| Cytokine | 0.1807 | INHERITED FROM: Hydroxycorticosteroids |
| vWA-like | 0.1877 | INHERITED FROM: Medroxyprogesterone || Medroxyprogesterone Acetate |
| "Winged helix" DNA-binding domain | 0.1938 | INHERITED FROM: mibolerone |
| ARM repeat | 0.1945 | INHERITED FROM: Molecular Mechanisms of Pharmacological Action || Enzyme Inhibitors |
| GroEL equatorial domain-like | 0.2281 | INHERITED FROM: Molecular Mechanisms of Pharmacological Action || Enzyme Inhibitors |
| NAD(P)-linked oxidoreductase | 0.2303 | INHERITED FROM: Thyroxine || 4-hydroxyequilenin-o-quinone || 16-ketoestrone || 11-Hydroxycorticosteroids || Desoxycorticosterone || Thyronines || Triiodothyronine || tetrahydrodeoxycorticosterone || Medroxyprogesterone || Equilenin || 20-alpha-Dihydroprogesterone || Estrone || 5-alpha-Dihydroprogesterone || Corticosterone || Medroxyprogesterone Acetate || Adrenal Cortex Hormones || 5-dihydrodeoxycorticosterone |
| GINS helical bundle-like | 0.2364 | INHERITED FROM: Testosterone |
| 5' to 3' exonuclease, C-terminal subdomain | 0.2364 | INHERITED FROM: Testosterone |
| Ribosomal proteins S24e, L23 and L15e | 0.2364 | INHERITED FROM: Molecular Mechanisms of Pharmacological Action || Enzyme Inhibitors |
| RNA-binding domain, RBD | 0.2502 | INHERITED FROM: Molecular Mechanisms of Pharmacological Action || Enzyme Inhibitors |
| UDP-Glycosyltransferase/glycogen phosphorylase | 0.2513 | INHERITED FROM: 2-Methoxyestradiol || 2-hydroxyestradiol || Pregnenolone Carbonitrile || Pregnenolone || Hydroxyestrones || 4-hydroxyestrone || Estrone || Androsterone || Estrogens, Catechol || Estriol || Adrenal Cortex Hormones |
| Acyl-CoA binding protein | 0.2749 | INHERITED FROM: Testosterone Congeners |
| SNF-like | 0.2793 | INHERITED FROM: Coloring Agents || Specialty Uses of Chemicals || Fluorescent Dyes |
| Hormone receptor domain | 0.2793 | INHERITED FROM: Peptide Hormones || Pituitary Hormone-Releasing Hormones |
| UBA-like | 0.2828 | INHERITED FROM: Molecular Mechanisms of Pharmacological Action || Enzyme Inhibitors |
| Insulin-like | 0.2854 | INHERITED FROM: Hypothalamic Hormones || 11-Hydroxycorticosteroids || 17-Hydroxycorticosteroids || Peptide Hormones || Testosterone Congeners || Hydroxycorticosteroids || Testosterone || Hydrocortisone |
| Cyclin-like | 0.2964 | INHERITED FROM: Fulvestrant || 2-Methoxyestradiol |
| ABC transporter transmembrane region | 0.3043 | INHERITED FROM: Methyltestosterone || Progesterone || Progesterone Congeners || Peptide Hormones || Corpus Luteum Hormones || Anticonvulsants || estradiol-17 beta-glucuronide || Central Nervous System Agents |
| SAP domain | 0.314 | INHERITED FROM: testosterone-3-carboxymethyloxime-bovine serum albumin conjugate || Molecular Mechanisms of Pharmacological Action || Enzyme Inhibitors |
| Blood coagulation inhibitor (disintegrin) | 0.3239 | INHERITED FROM: Thyroxine || Thyronines || Triiodothyronine |
| GroEL-intermediate domain like | 0.3546 | INHERITED FROM: Molecular Mechanisms of Pharmacological Action || Enzyme Inhibitors |
| Nucleic acid-binding proteins | 0.3583 | INHERITED FROM: Molecular Mechanisms of Pharmacological Action || Enzyme Inhibitors |
| Thioredoxin-like | 0.3649 | INHERITED FROM: 17-Ketosteroids |
| PYP-like sensor domain (PAS domain) | 0.4086 | INHERITED FROM: Thyroxine || Fulvestrant || Thyronines || Triiodothyronine || Adrenal Cortex Hormones |
| GroEL apical domain-like | 0.414 | INHERITED FROM: Molecular Mechanisms of Pharmacological Action || Enzyme Inhibitors |
| R3H domain | 0.4328 | INHERITED FROM: Molecular Mechanisms of Pharmacological Action || Enzyme Inhibitors |
| Class II aaRS ABD-related | 0.4899 | INHERITED FROM: Enzyme Inhibitors |
| TNF-like | 0.5592 | INHERITED FROM: Hydroxyprogesterones || Medroxyprogesterone Acetate |
| Translation proteins | 0.621 | INHERITED FROM: Enzyme Inhibitors |
| Periplasmic binding protein-like I | 0.6699 | INHERITED FROM: Excitatory Amino Acid Agonists || Excitatory Amino Acid Agents || Neurotransmitter Agents |
| Metallo-hydrolase/oxidoreductase | 0.6885 | INHERITED FROM: Air Pollutants, Occupational |
| Histone-fold | 0.8173 | INHERITED FROM: Environmental Pollutants || Air Pollutants |
| HLH, helix-loop-helix DNA-binding domain | 0.8521 | INHERITED FROM: Dihydrotestosterone || testosterone-3-carboxymethyloxime-bovine serum albumin conjugate |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.8661 | INHERITED FROM: Flame Retardants || GABA Agents || Neurotransmitter Agents |
| Nicotinic receptor ligand binding domain-like | 0.8661 | INHERITED FROM: Flame Retardants || GABA Agents || Neurotransmitter Agents |
| Fibrinogen C-terminal domain-like | 0.9116 | INHERITED FROM: ethinyl estradiol-desogestrel combination || estradiol valerate-dienogest || Progesterone || Progesterone Congeners || Nandrolone || Corpus Luteum Hormones || dienogest |
| Trypsin-like serine proteases | 0.9942 | INHERITED FROM: ethinyl estradiol-desogestrel combination || estradiol, norethindrone drug combination || estradiol valerate-dienogest || Estrogenic Steroids, Alkylated || Medroxyprogesterone || Protease Inhibitors || NuvaRing || Nandrolone || Reproductive Control Agents || Medroxyprogesterone Acetate |
| Family A G protein-coupled receptor-like | 1 | INHERITED FROM: Peptide Hormones |
| L domain-like | 1 | INHERITED FROM: Insulins || Antineoplastic Agents |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| Ribosomal protein L30p/L7e | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | Direct |
| Hook domain | 0 | Direct |
| P-domain of calnexin/calreticulin | 0 | Direct |
| STAT | 0 | Direct |
| Thyroglobulin type-1 domain | 0 | Direct |
| AhpD-like | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| Metallothionein | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Nucleoporin domain | 0 | Direct |
| FAD-dependent thiol oxidase | 0 | Direct |
| LanC-like | 0 | Direct |
| PurM N-terminal domain-like | 0 | Direct |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
| WGR domain-like | 0 | Direct |
| Surp module (SWAP domain) | 0 | Direct |
| ATP-dependent DNA ligase DNA-binding domain | 0 | Direct |
| BSD domain-like | 0 | Direct |
| Protein serine/threonine phosphatase 2C, C-terminal domain | 0 | Direct |
| G protein-binding domain | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| L-aspartase-like | 0 | Direct |
| AraD/HMP-PK domain-like | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
| Phosphoenolpyruvate/pyruvate domain | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| Mitochondrial cytochrome c oxidase subunit VIIa | 0 | Direct |
| MgtE membrane domain-like | 0 | Direct |
| GHMP Kinase, C-terminal domain | 0 | Direct |
| Transcription factor STAT-4 N-domain | 0 | Direct |
| eIF1-like | 0 | Direct |
| HMA, heavy metal-associated domain | 0 | Direct |
| PurM C-terminal domain-like | 0 | Direct |
| 3-carboxy-cis,cis-mucoante lactonizing enzyme | 0 | Direct |
| beta-lactamase/transpeptidase-like | 0 | Direct |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| Bcl-2 inhibitors of programmed cell death | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| DLC | 0 | Direct |
| Fibrinogen coiled-coil and central regions | 0 | Direct |
| A heparin-binding domain | 0 | Direct |
| GTF2I-like repeat | 0 | Direct |
| N-terminal domain of cbl (N-cbl) | 0 | Direct |
| Domain of poly(ADP-ribose) polymerase | 0 | Direct |
| ITPase-like | 0 | Direct |
| PAH2 domain | 0 | Direct |
| Indolic compounds 2,3-dioxygenase-like | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Nucleoplasmin-like core domain | 0 | Direct |
| Proteasome activator | 0 | Direct |
| Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain | 0 | Direct |
| BAG domain | 0 | Direct |
| EPT/RTPC-like | 0 | Direct |
| Nicotinate/Quinolinate PRTase C-terminal domain-like | 0 | Direct |
| RNase III domain-like | 0 | Direct |
| Anaphylotoxins (complement system) | 0 | Direct |
| p53 tetramerization domain | 0 | Direct |
| HIN-2000 domain-like | 0 | Direct |
| Synuclein | 0 | Direct |
| CCHHC domain | 0 | Direct |
| Eferin C-derminal domain-like | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | Direct |
| RGC domain-like | 0 | Direct |
| Ribosomal protein L10-like | 0 | Direct |
| DEK C-terminal domain | 0 | Direct |
| MAPEG domain-like | 0 | Direct |
| Ribosomal protein S10 | 0 | Direct |
| C-terminal domain of PLC-beta | 0 | Direct |
| occludin/ELL-like | 0 | Direct |
| PH domain-like | 0.000000007355 | Direct |
| Cytochrome P450 | 0.000002984 | Direct |
| SH2 domain | 0.0000224 | Direct |
| Calponin-homology domain, CH-domain | 0.00008315 | Direct |
| Leucine zipper domain | 0.0001371 | Direct |
| Nuclear receptor ligand-binding domain | 0.0001424 | Direct |
| EGF/Laminin | 0.0002257 | Direct |
| SH3-domain | 0.0004182 | Direct |
| GTPase activation domain, GAP | 0.0004916 | Direct |
| Protein kinase-like (PK-like) | 0.0005457 | Direct |
| BRCT domain | 0.0005826 | Direct |
| DBL homology domain (DH-domain) | 0.0006323 | Direct |
| Growth factor receptor domain | 0.001059 | Inherited |
| P-loop containing nucleoside triphosphate hydrolases | 0.001248 | Inherited |
| DEATH domain | 0.001411 | Inherited |
| Fibronectin type III | 0.001514 | Inherited |
| Caspase-like | 0.001979 | Inherited |
| Cytochrome b5-like heme/steroid binding domain | 0.003183 | Inherited |
| Plexin repeat | 0.003363 | Inherited |
| Kringle-like | 0.006021 | Inherited |
| Interleukin 8-like chemokines | 0.006401 | Inherited |
| Nucleotidylyl transferase | 0.008045 | Inherited |
| p53-like transcription factors | 0.00854 | Inherited |
| Integrin domains | 0.008593 | Inherited |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0.008651 | Inherited |
| Cystine-knot cytokines | 0.01107 | Inherited |
| FAD/NAD(P)-binding domain | 0.01188 | Inherited |
| Sema domain | 0.01367 | Inherited |
| Immunoglobulin | 0.01454 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.01573 | Inherited |
| Complement control module/SCR domain | 0.01585 | Inherited |
| C-terminal, gelsolin-like domain of Sec23/24 | 0.01991 | Inherited |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.01991 | Inherited |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.01991 | Inherited |
| Serpins | 0.02343 | Inherited |
| Rhodanese/Cell cycle control phosphatase | 0.0239 | Inherited |
| GST C-terminal domain-like | 0.02539 | Inherited |
| Arginase/deacetylase | 0.02548 | Inherited |
| GLA-domain | 0.02548 | Inherited |
| 4-helical cytokines | 0.03122 | Inherited |
| NAD(P)-binding Rossmann-fold domains | 0.03606 | Inherited |
| Ribosomal protein S5 domain 2-like | 0.03947 | Inherited |
| MHC antigen-recognition domain | 0.04176 | Inherited |
| dsRNA-binding domain-like | 0.04371 | Inherited |
| VHP, Villin headpiece domain | 0.04724 | Inherited |
| Inhibitor of apoptosis (IAP) repeat | 0.04724 | Inherited |
| Integrin alpha N-terminal domain | 0.05174 | Inherited |
| Hemopexin-like domain | 0.05174 | Inherited |
| PGBD-like | 0.06078 | Inherited |
| Metalloproteases ("zincins"), catalytic domain | 0.06299 | Inherited |
| Periplasmic binding protein-like II | 0.06817 | Inherited |
| Integrin beta tail domain | 0.0718 | Inherited |
| S15/NS1 RNA-binding domain | 0.0718 | Inherited |
| Eukaryotic type KH-domain (KH-domain type I) | 0.1025 | Inherited |
| Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain | 0.1072 | Inherited |
| post-AAA+ oligomerization domain-like | 0.108 | Inherited |
| MFS general substrate transporter | 0.1153 | Inherited |
| FnI-like domain | 0.1255 | Inherited |
| A DNA-binding domain in eukaryotic transcription factors | 0.1392 | Inherited |
| Cupredoxins | 0.1463 | Inherited |
| SPOC domain-like | 0.1604 | Inherited |
| Kazal-type serine protease inhibitors | 0.1632 | Inherited |
| beta-sandwich domain of Sec23/24 | 0.1688 | Inherited |
| Cytokine | 0.1807 | Inherited |
| vWA-like | 0.1877 | Inherited |
| "Winged helix" DNA-binding domain | 0.1938 | Inherited |
| ARM repeat | 0.1945 | Inherited |
| GroEL equatorial domain-like | 0.2281 | Inherited |
| NAD(P)-linked oxidoreductase | 0.2303 | Inherited |
| GINS helical bundle-like | 0.2364 | Inherited |
| 5' to 3' exonuclease, C-terminal subdomain | 0.2364 | Inherited |
| Ribosomal proteins S24e, L23 and L15e | 0.2364 | Inherited |
| RNA-binding domain, RBD | 0.2502 | Inherited |
| UDP-Glycosyltransferase/glycogen phosphorylase | 0.2513 | Inherited |
| Acyl-CoA binding protein | 0.2749 | Inherited |
| SNF-like | 0.2793 | Inherited |
| Hormone receptor domain | 0.2793 | Inherited |
| UBA-like | 0.2828 | Inherited |
| Insulin-like | 0.2854 | Inherited |
| Cyclin-like | 0.2964 | Inherited |
| ABC transporter transmembrane region | 0.3043 | Inherited |
| SAP domain | 0.314 | Inherited |
| Blood coagulation inhibitor (disintegrin) | 0.3239 | Inherited |
| GroEL-intermediate domain like | 0.3546 | Inherited |
| Nucleic acid-binding proteins | 0.3583 | Inherited |
| Thioredoxin-like | 0.3649 | Inherited |
| PYP-like sensor domain (PAS domain) | 0.4086 | Inherited |
| GroEL apical domain-like | 0.414 | Inherited |
| R3H domain | 0.4328 | Inherited |
| Class II aaRS ABD-related | 0.4899 | Inherited |
| TNF-like | 0.5592 | Inherited |
| Translation proteins | 0.621 | Inherited |
| Periplasmic binding protein-like I | 0.6699 | Inherited |
| Metallo-hydrolase/oxidoreductase | 0.6885 | Inherited |
| Histone-fold | 0.8173 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.8521 | Inherited |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.8661 | Inherited |
| Nicotinic receptor ligand binding domain-like | 0.8661 | Inherited |
| Fibrinogen C-terminal domain-like | 0.9116 | Inherited |
| Trypsin-like serine proteases | 0.9942 | Inherited |
| Family A G protein-coupled receptor-like | 1 | Inherited |
| L domain-like | 1 | Inherited |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Duplex) in N- to C-terminal order( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
53850,53850
53850 - Periplasmic binding protein-like II
53850 - Periplasmic binding protein-like II | 0 | DIRECT |
57903,63748
57903 - FYVE/PHD zinc finger
63748 - Tudor/PWWP/MBT | 0 | DIRECT |
46942,57783
46942 - Elongation factor TFIIS domain 2
57783 - Zinc beta-ribbon | 0 | DIRECT |
54236,57889
54236 - Ubiquitin-like
57889 - Cysteine-rich domain | 0 | DIRECT |
81811,82754
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
69012,55874
69012 - alpha-ketoacid dehydrogenase kinase, N-terminal domain
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | DIRECT |
49410,50242
49410 - Alpha-macroglobulin receptor domain
50242 - TIMP-like | 0 | DIRECT |
53098,56672
53098 - Ribonuclease H-like
56672 - DNA/RNA polymerases | 0 | DIRECT |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
57889,49562
57889 - Cysteine-rich domain
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
48403,47986
48403 - Ankyrin repeat
47986 - DEATH domain | 0 | DIRECT |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0 | DIRECT |
54403,54403
54403 - Cystatin/monellin
54403 - Cystatin/monellin | 0 | DIRECT |
50044,47769
50044 - SH3-domain
47769 - SAM/Pointed domain | 0 | DIRECT |
57535,57196
57535 - Complement control module/SCR domain
57196 - EGF/Laminin | 0 | DIRECT |
55874,54211
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
100934,100934
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
55326,56042
55326 - PurM N-terminal domain-like
56042 - PurM C-terminal domain-like | 0 | DIRECT |
142921,47587
142921 - WGR domain-like
47587 - Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
49562,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain | 0 | DIRECT |
48452,46785
48452 - TPR-like
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
69065,54768
69065 - RNase III domain-like
54768 - dsRNA-binding domain-like | 0 | DIRECT |
52540,-7
52540 - P-loop containing nucleoside triphosphate hydrolases
-7 - CATH | 0 | DIRECT |
-8,54980
-8 - ECOD
54980 - EF-G C-terminal domain-like | 0 | DIRECT |
52540,81271
52540 - P-loop containing nucleoside triphosphate hydrolases
81271 - TGS-like | 0 | DIRECT |
54211,55060
54211 - Ribosomal protein S5 domain 2-like
55060 - GHMP Kinase, C-terminal domain | 0 | DIRECT |
82199,57903
82199 - SET domain
57903 - FYVE/PHD zinc finger | 0 | DIRECT |
54534,54534
54534 - FKBP-like
54534 - FKBP-like | 0 | DIRECT |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | DIRECT |
52058,49265
52058 - L domain-like
49265 - Fibronectin type III | 0 | DIRECT |
48371,-7
48371 - ARM repeat
-7 - CATH | 0 | DIRECT |
48452,57850
48452 - TPR-like
57850 - RING/U-box | 0 | DIRECT |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0 | DIRECT |
81995,81811
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24 | 0 | DIRECT |
47576,48065
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain) | 0 | DIRECT |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
47862,47862
47862 - Saposin
47862 - Saposin | 0 | DIRECT |
47473,55550
47473 - EF-hand
55550 - SH2 domain | 0 | DIRECT |
63748,57903
63748 - Tudor/PWWP/MBT
57903 - FYVE/PHD zinc finger | 0 | DIRECT |
64268,56112
64268 - PX domain
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
81837,50978
81837 - BEACH domain
50978 - WD40 repeat-like | 0 | DIRECT |
50370,57440
50370 - Ricin B-like lectins
57440 - Kringle-like | 0 | DIRECT |
53300,57184
53300 - vWA-like
57184 - Growth factor receptor domain | 0 | DIRECT |
47060,55681
47060 - S15/NS1 RNA-binding domain
55681 - Class II aaRS and biotin synthetases | 0 | DIRECT |
54236,48366
54236 - Ubiquitin-like
48366 - Ras GEF | 0 | DIRECT |
53822,53850
53822 - Periplasmic binding protein-like I
53850 - Periplasmic binding protein-like II | 0 | DIRECT |
52540,53254
52540 - P-loop containing nucleoside triphosphate hydrolases
53254 - Phosphoglycerate mutase-like | 0 | DIRECT |
57440,56436
57440 - Kringle-like
56436 - C-type lectin-like | 0 | DIRECT |
57889,50729
57889 - Cysteine-rich domain
50729 - PH domain-like | 0 | DIRECT |
103637,103637
103637 - CCHHC domain
103637 - CCHHC domain | 0 | DIRECT |
50729,57903
50729 - PH domain-like
57903 - FYVE/PHD zinc finger | 0 | DIRECT |
49899,63887
49899 - Concanavalin A-like lectins/glucanases
63887 - P-domain of calnexin/calreticulin | 0 | DIRECT |
117839,56399
117839 - WWE domain
56399 - ADP-ribosylation | 0 | DIRECT |
57850,48452
57850 - RING/U-box
48452 - TPR-like | 0 | DIRECT |
55550,57850
55550 - SH2 domain
57850 - RING/U-box | 0 | DIRECT |
57863,50729
57863 - ArfGap/RecO-like zinc finger
50729 - PH domain-like | 0 | DIRECT |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0 | DIRECT |
49417,47719
49417 - p53-like transcription factors
47719 - p53 tetramerization domain | 0 | DIRECT |
52949,52949
52949 - Macro domain-like
52949 - Macro domain-like | 0 | DIRECT |
57184,57610
57184 - Growth factor receptor domain
57610 - Thyroglobulin type-1 domain | 0 | DIRECT |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0 | DIRECT |
90193,90193
90193 - Notch domain
90193 - Notch domain | 0 | DIRECT |
47473,57610
47473 - EF-hand
57610 - Thyroglobulin type-1 domain | 0 | DIRECT |
46785,54928
46785 - "Winged helix" DNA-binding domain
54928 - RNA-binding domain, RBD | 0 | DIRECT |
100895,47473
100895 - Kazal-type serine protease inhibitors
47473 - EF-hand | 0 | DIRECT |
159141,159141
159141 - HIN-2000 domain-like
159141 - HIN-2000 domain-like | 0 | DIRECT |
117018,56091
117018 - ATP-dependent DNA ligase DNA-binding domain
56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
48670,48097
48670 - Transducin (heterotrimeric G protein), gamma chain
48097 - Regulator of G-protein signaling, RGS | 0 | DIRECT |
90188,53649
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like | 0 | DIRECT |
47986,52129
47986 - DEATH domain
52129 - Caspase-like | 0 | DIRECT |
54826,51604
54826 - Enolase N-terminal domain-like
51604 - Enolase C-terminal domain-like | 0 | DIRECT |
63748,82199
63748 - Tudor/PWWP/MBT
82199 - SET domain | 0 | DIRECT |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
47587,56399
47587 - Domain of poly(ADP-ribose) polymerase
56399 - ADP-ribosylation | 0 | DIRECT |
54919,54919
54919 - Nucleoside diphosphate kinase, NDK
54919 - Nucleoside diphosphate kinase, NDK | 0 | DIRECT |
48350,55961
48350 - GTPase activation domain, GAP
55961 - Bet v1-like | 0 | DIRECT |
57667,140996
57667 - beta-beta-alpha zinc fingers
140996 - Hermes dimerisation domain | 0 | DIRECT |
53300,49899
53300 - vWA-like
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
55486,49854
55486 - Metalloproteases ("zincins"), catalytic domain
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
100920,100934
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
69572,69572
69572 - Activating enzymes of the ubiquitin-like proteins
69572 - Activating enzymes of the ubiquitin-like proteins | 0 | DIRECT |
52087,48350
52087 - CRAL/TRIO domain
48350 - GTPase activation domain, GAP | 0 | DIRECT |
50729,57889
50729 - PH domain-like
57889 - Cysteine-rich domain | 0 | DIRECT |
54236,50729
54236 - Ubiquitin-like
50729 - PH domain-like | 0 | DIRECT |
56491,89811
56491 - A heparin-binding domain
89811 - Amyloid beta a4 protein copper binding domain (domain 2) | 0 | DIRECT |
57850,88697
57850 - RING/U-box
88697 - PUA domain-like | 0 | DIRECT |
57889,48350
57889 - Cysteine-rich domain
48350 - GTPase activation domain, GAP | 0 | DIRECT |
81606,81601
81606 - PP2C-like
81601 - Protein serine/threonine phosphatase 2C, C-terminal domain | 0 | DIRECT |
56112,50729
56112 - Protein kinase-like (PK-like)
50729 - PH domain-like | 0 | DIRECT |
48366,47473
48366 - Ras GEF
47473 - EF-hand | 0 | DIRECT |
57196,57535
57196 - EGF/Laminin
57535 - Complement control module/SCR domain | 0 | DIRECT |
51905,55424
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
57184,49265
57184 - Growth factor receptor domain
49265 - Fibronectin type III | 0 | DIRECT |
57414,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like | 0 | DIRECT |
103575,81296
103575 - Plexin repeat
81296 - E set domains | 0 | DIRECT |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0 | DIRECT |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | DIRECT |
56091,50249
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
63501,50242
63501 - Frizzled cysteine-rich domain
50242 - TIMP-like | 0 | DIRECT |
50447,-8
50447 - Translation proteins
-8 - ECOD | 0 | DIRECT |
53300,81995
53300 - vWA-like
81995 - beta-sandwich domain of Sec23/24 | 0 | DIRECT |
48371,101447
48371 - ARM repeat
101447 - Formin homology 2 domain (FH2 domain) | 0 | DIRECT |
161093,161093
161093 - MgtE membrane domain-like
161093 - MgtE membrane domain-like | 0 | DIRECT |
47668,47473
47668 - N-terminal domain of cbl (N-cbl)
47473 - EF-hand | 0 | DIRECT |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.0002173 | DIRECT |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.0002865 | DIRECT |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0.0003454 | DIRECT |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.001412 | INHERITED FROM: Gonadal Hormones || Pharmacologic Actions || Estradiol || Hormones, Hormone Substitutes, and Hormone Antagonists |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.001628 | INHERITED FROM: Molecular Mechanisms of Pharmacological Action || Enzyme Inhibitors |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.002231 | INHERITED FROM: Protein Kinase Inhibitors || Therapeutic Uses |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.005727 | INHERITED FROM: Dehydroepiandrosterone || Agrochemicals || Hypothalamic Hormones || Estrogens || Fulvestrant || Toxic Actions || Specialty Uses of Chemicals || Melatonin || Medroxyprogesterone || 17-Ketosteroids || Soil Pollutants || tetraiodothyroacetic acid || Estrone || Pesticides || 3,3',5-triiodothyroacetic acid || 17-alpha-Hydroxyprogesterone || Estriol || Medroxyprogesterone Acetate || Adrenal Cortex Hormones |
52821,52799
52821 - Rhodanese/Cell cycle control phosphatase
52799 - (Phosphotyrosine protein) phosphatases II | 0.01274 | INHERITED FROM: Environmental Pollutants || Air Pollutants |
101912,103575
101912 - Sema domain
103575 - Plexin repeat | 0.01367 | INHERITED FROM: Gonadal Hormones || Estradiol || Hormones, Hormone Substitutes, and Hormone Antagonists |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0.01854 | INHERITED FROM: Protease Inhibitors || Angiotensin-Converting Enzyme Inhibitors || Therapeutic Uses || Antirheumatic Agents |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.01991 | INHERITED FROM: Enzyme Inhibitors |
54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 0.01991 | INHERITED FROM: Molecular Mechanisms of Pharmacological Action || Enzyme Inhibitors |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0.01991 | INHERITED FROM: Protein Kinase Inhibitors |
57889,57889
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0.02548 | INHERITED FROM: Specialty Uses of Chemicals || Pesticides |
69318,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0.02575 | INHERITED FROM: Progesterone || Progesterone Congeners || Corpus Luteum Hormones |
69179,69179
69179 - Integrin domains
69179 - Integrin domains | 0.02575 | INHERITED FROM: Progesterone || Progesterone Congeners || Corpus Luteum Hormones |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 0.03312 | INHERITED FROM: Agrochemicals || Androstenedione || 17-Ketosteroids || Adrenal Cortex Hormones |
81296,81296
81296 - E set domains
81296 - E set domains | 0.04494 | INHERITED FROM: Estradiol |
50729,81837
50729 - PH domain-like
81837 - BEACH domain | 0.04724 | INHERITED FROM: Air Pollutants |
55550,158235
55550 - SH2 domain
158235 - SOCS box-like | 0.04724 | INHERITED FROM: Protein Kinase Inhibitors |
54791,54791
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I) | 0.05174 | INHERITED FROM: Molecular Mechanisms of Pharmacological Action || Enzyme Inhibitors |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0.06078 | INHERITED FROM: Gonadal Hormones || Matrix Metalloproteinase Inhibitors || Progesterone || Physiological Effects of Drugs || Estradiol Congeners || Protease Inhibitors || Phospholipase A2 Inhibitors || Nandrolone || mibolerone || Estradiol || Hormones, Hormone Substitutes, and Hormone Antagonists |
57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0.06925 | INHERITED FROM: Perfume |
57196,69687
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0.0718 | INHERITED FROM: Progesterone || Progesterone Congeners || Corpus Luteum Hormones |
53300,69179
53300 - vWA-like
69179 - Integrin domains | 0.0718 | INHERITED FROM: Progesterone |
103473,100895
103473 - MFS general substrate transporter
100895 - Kazal-type serine protease inhibitors | 0.07623 | INHERITED FROM: estrone sulfate || 3-iodothyronamine || Thyroid Hormones || Thyronines || 17-Ketosteroids || Estrone || Adrenal Cortex Hormones |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.07963 | INHERITED FROM: Gonadal Hormones || Progesterone || Physiological Effects of Drugs || Hormones, Hormone Substitutes, and Hormone Antagonists |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.08095 | INHERITED FROM: Matrix Metalloproteinase Inhibitors || Estradiol Congeners || Protease Inhibitors || Estradiol |
52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.1069 | INHERITED FROM: Dihydrotestosterone |
52540,48340
52540 - P-loop containing nucleoside triphosphate hydrolases
48340 - Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain | 0.1072 | INHERITED FROM: Therapeutic Uses || Antirheumatic Agents |
57630,57196
57630 - GLA-domain
57196 - EGF/Laminin | 0.108 | INHERITED FROM: estradiol, norethindrone drug combination || Progesterone || Progesterone Congeners || Estrogenic Steroids, Alkylated || Medroxyprogesterone || Corpus Luteum Hormones || Reproductive Control Agents || Medroxyprogesterone Acetate |
52540,48019
52540 - P-loop containing nucleoside triphosphate hydrolases
48019 - post-AAA+ oligomerization domain-like | 0.108 | INHERITED FROM: Enzyme Inhibitors |
47095,47095
47095 - HMG-box
47095 - HMG-box | 0.108 | INHERITED FROM: Molecular Mechanisms of Pharmacological Action || Enzyme Inhibitors |
48371,48371
48371 - ARM repeat
48371 - ARM repeat | 0.1475 | INHERITED FROM: Molecular Mechanisms of Pharmacological Action || Enzyme Inhibitors |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.1486 | INHERITED FROM: ethinyl estradiol-desogestrel combination || Progesterone || Progesterone Congeners || Medroxyprogesterone || Corpus Luteum Hormones || Medroxyprogesterone Acetate |
53300,69318
53300 - vWA-like
69318 - Integrin alpha N-terminal domain | 0.1486 | INHERITED FROM: Progesterone || Progesterone Congeners || Medroxyprogesterone || Corpus Luteum Hormones || Medroxyprogesterone Acetate |
64268,103657
64268 - PX domain
103657 - BAR/IMD domain-like | 0.1604 | INHERITED FROM: Molecular Mechanisms of Pharmacological Action || Enzyme Inhibitors |
49503,49503
49503 - Cupredoxins
49503 - Cupredoxins | 0.1604 | INHERITED FROM: ethinyl estradiol-desogestrel combination || Estrogenic Steroids, Alkylated |
49899,52540
49899 - Concanavalin A-like lectins/glucanases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1604 | INHERITED FROM: Molecular Mechanisms of Pharmacological Action || Enzyme Inhibitors |
47454,57959
47454 - A DNA-binding domain in eukaryotic transcription factors
57959 - Leucine zipper domain | 0.1791 | INHERITED FROM: Agrochemicals |
49785,49785
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like | 0.2036 | INHERITED FROM: Estrogenic Steroids, Alkylated |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0.2036 | INHERITED FROM: Testosterone |
56487,56487
56487 - SRCR-like
56487 - SRCR-like | 0.2214 | INHERITED FROM: Medroxyprogesterone || Medroxyprogesterone Acetate |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0.2214 | INHERITED FROM: Molecular Mechanisms of Pharmacological Action || Enzyme Inhibitors |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0.2214 | INHERITED FROM: ethinyl estradiol-desogestrel combination || 11-Hydroxycorticosteroids || Progesterone || Progesterone Congeners || 17-Hydroxycorticosteroids || Estrogenic Steroids, Alkylated || Medroxyprogesterone || Protease Inhibitors || Hydroxyprogesterones || Corpus Luteum Hormones || Hydroxycorticosteroids || Medroxyprogesterone Acetate |
111418,81321
111418 - Hormone receptor domain
81321 - Family A G protein-coupled receptor-like | 0.2281 | INHERITED FROM: Peptide Hormones || Pituitary Hormone-Releasing Hormones |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0.2303 | INHERITED FROM: Thyroxine || Fulvestrant || Thyroid Hormones || testosterone-3-carboxymethyloxime-bovine serum albumin conjugate || Thyronines || Triiodothyronine || Adrenal Cortex Hormones |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.3043 | INHERITED FROM: Methyltestosterone || Progesterone || Progesterone Congeners || Peptide Hormones || Corpus Luteum Hormones || Anticonvulsants || estradiol-17 beta-glucuronide || Central Nervous System Agents |
55486,57552
55486 - Metalloproteases ("zincins"), catalytic domain
57552 - Blood coagulation inhibitor (disintegrin) | 0.3239 | INHERITED FROM: Thyroxine || Thyronines || Triiodothyronine |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.3546 | INHERITED FROM: Molecular Mechanisms of Pharmacological Action || Enzyme Inhibitors |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.3624 | INHERITED FROM: Thyroxine || Fulvestrant || Thyroid Hormones || testosterone-3-carboxymethyloxime-bovine serum albumin conjugate || Thyronines || Triiodothyronine || 17-Ketosteroids || Adrenal Cortex Hormones |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.4068 | INHERITED FROM: Fulvestrant || 2-Methoxyestradiol || Thyronines || Triiodothyronine |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.8661 | INHERITED FROM: Flame Retardants || GABA Agents || Neurotransmitter Agents |
47986,52540
47986 - DEATH domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.9638 | INHERITED FROM: Air Pollutants, Occupational |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
53850,53850
53850 - Periplasmic binding protein-like II
53850 - Periplasmic binding protein-like II | 0 | Direct |
57903,63748
57903 - FYVE/PHD zinc finger
63748 - Tudor/PWWP/MBT | 0 | Direct |
46942,57783
46942 - Elongation factor TFIIS domain 2
57783 - Zinc beta-ribbon | 0 | Direct |
54236,57889
54236 - Ubiquitin-like
57889 - Cysteine-rich domain | 0 | Direct |
81811,82754
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
69012,55874
69012 - alpha-ketoacid dehydrogenase kinase, N-terminal domain
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | Direct |
49410,50242
49410 - Alpha-macroglobulin receptor domain
50242 - TIMP-like | 0 | Direct |
53098,56672
53098 - Ribonuclease H-like
56672 - DNA/RNA polymerases | 0 | Direct |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | Direct |
57889,49562
57889 - Cysteine-rich domain
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
48403,47986
48403 - Ankyrin repeat
47986 - DEATH domain | 0 | Direct |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0 | Direct |
54403,54403
54403 - Cystatin/monellin
54403 - Cystatin/monellin | 0 | Direct |
50044,47769
50044 - SH3-domain
47769 - SAM/Pointed domain | 0 | Direct |
57535,57196
57535 - Complement control module/SCR domain
57196 - EGF/Laminin | 0 | Direct |
55874,54211
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
100934,100934
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
55326,56042
55326 - PurM N-terminal domain-like
56042 - PurM C-terminal domain-like | 0 | Direct |
142921,47587
142921 - WGR domain-like
47587 - Domain of poly(ADP-ribose) polymerase | 0 | Direct |
49562,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain | 0 | Direct |
48452,46785
48452 - TPR-like
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
69065,54768
69065 - RNase III domain-like
54768 - dsRNA-binding domain-like | 0 | Direct |
52540,-7
52540 - P-loop containing nucleoside triphosphate hydrolases
-7 - CATH | 0 | Direct |
-8,54980
-8 - ECOD
54980 - EF-G C-terminal domain-like | 0 | Direct |
52540,81271
52540 - P-loop containing nucleoside triphosphate hydrolases
81271 - TGS-like | 0 | Direct |
54211,55060
54211 - Ribosomal protein S5 domain 2-like
55060 - GHMP Kinase, C-terminal domain | 0 | Direct |
82199,57903
82199 - SET domain
57903 - FYVE/PHD zinc finger | 0 | Direct |
54534,54534
54534 - FKBP-like
54534 - FKBP-like | 0 | Direct |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | Direct |
52058,49265
52058 - L domain-like
49265 - Fibronectin type III | 0 | Direct |
48371,-7
48371 - ARM repeat
-7 - CATH | 0 | Direct |
48452,57850
48452 - TPR-like
57850 - RING/U-box | 0 | Direct |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0 | Direct |
81995,81811
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24 | 0 | Direct |
47576,48065
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain) | 0 | Direct |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
47862,47862
47862 - Saposin
47862 - Saposin | 0 | Direct |
47473,55550
47473 - EF-hand
55550 - SH2 domain | 0 | Direct |
63748,57903
63748 - Tudor/PWWP/MBT
57903 - FYVE/PHD zinc finger | 0 | Direct |
64268,56112
64268 - PX domain
56112 - Protein kinase-like (PK-like) | 0 | Direct |
81837,50978
81837 - BEACH domain
50978 - WD40 repeat-like | 0 | Direct |
50370,57440
50370 - Ricin B-like lectins
57440 - Kringle-like | 0 | Direct |
53300,57184
53300 - vWA-like
57184 - Growth factor receptor domain | 0 | Direct |
47060,55681
47060 - S15/NS1 RNA-binding domain
55681 - Class II aaRS and biotin synthetases | 0 | Direct |
54236,48366
54236 - Ubiquitin-like
48366 - Ras GEF | 0 | Direct |
53822,53850
53822 - Periplasmic binding protein-like I
53850 - Periplasmic binding protein-like II | 0 | Direct |
52540,53254
52540 - P-loop containing nucleoside triphosphate hydrolases
53254 - Phosphoglycerate mutase-like | 0 | Direct |
57440,56436
57440 - Kringle-like
56436 - C-type lectin-like | 0 | Direct |
57889,50729
57889 - Cysteine-rich domain
50729 - PH domain-like | 0 | Direct |
103637,103637
103637 - CCHHC domain
103637 - CCHHC domain | 0 | Direct |
50729,57903
50729 - PH domain-like
57903 - FYVE/PHD zinc finger | 0 | Direct |
49899,63887
49899 - Concanavalin A-like lectins/glucanases
63887 - P-domain of calnexin/calreticulin | 0 | Direct |
117839,56399
117839 - WWE domain
56399 - ADP-ribosylation | 0 | Direct |
57850,48452
57850 - RING/U-box
48452 - TPR-like | 0 | Direct |
55550,57850
55550 - SH2 domain
57850 - RING/U-box | 0 | Direct |
57863,50729
57863 - ArfGap/RecO-like zinc finger
50729 - PH domain-like | 0 | Direct |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0 | Direct |
49417,47719
49417 - p53-like transcription factors
47719 - p53 tetramerization domain | 0 | Direct |
52949,52949
52949 - Macro domain-like
52949 - Macro domain-like | 0 | Direct |
57184,57610
57184 - Growth factor receptor domain
57610 - Thyroglobulin type-1 domain | 0 | Direct |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0 | Direct |
90193,90193
90193 - Notch domain
90193 - Notch domain | 0 | Direct |
47473,57610
47473 - EF-hand
57610 - Thyroglobulin type-1 domain | 0 | Direct |
46785,54928
46785 - "Winged helix" DNA-binding domain
54928 - RNA-binding domain, RBD | 0 | Direct |
100895,47473
100895 - Kazal-type serine protease inhibitors
47473 - EF-hand | 0 | Direct |
159141,159141
159141 - HIN-2000 domain-like
159141 - HIN-2000 domain-like | 0 | Direct |
117018,56091
117018 - ATP-dependent DNA ligase DNA-binding domain
56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
48670,48097
48670 - Transducin (heterotrimeric G protein), gamma chain
48097 - Regulator of G-protein signaling, RGS | 0 | Direct |
90188,53649
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like | 0 | Direct |
47986,52129
47986 - DEATH domain
52129 - Caspase-like | 0 | Direct |
54826,51604
54826 - Enolase N-terminal domain-like
51604 - Enolase C-terminal domain-like | 0 | Direct |
63748,82199
63748 - Tudor/PWWP/MBT
82199 - SET domain | 0 | Direct |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
47587,56399
47587 - Domain of poly(ADP-ribose) polymerase
56399 - ADP-ribosylation | 0 | Direct |
54919,54919
54919 - Nucleoside diphosphate kinase, NDK
54919 - Nucleoside diphosphate kinase, NDK | 0 | Direct |
48350,55961
48350 - GTPase activation domain, GAP
55961 - Bet v1-like | 0 | Direct |
57667,140996
57667 - beta-beta-alpha zinc fingers
140996 - Hermes dimerisation domain | 0 | Direct |
53300,49899
53300 - vWA-like
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
55486,49854
55486 - Metalloproteases ("zincins"), catalytic domain
49854 - Spermadhesin, CUB domain | 0 | Direct |
100920,100934
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
69572,69572
69572 - Activating enzymes of the ubiquitin-like proteins
69572 - Activating enzymes of the ubiquitin-like proteins | 0 | Direct |
52087,48350
52087 - CRAL/TRIO domain
48350 - GTPase activation domain, GAP | 0 | Direct |
50729,57889
50729 - PH domain-like
57889 - Cysteine-rich domain | 0 | Direct |
54236,50729
54236 - Ubiquitin-like
50729 - PH domain-like | 0 | Direct |
56491,89811
56491 - A heparin-binding domain
89811 - Amyloid beta a4 protein copper binding domain (domain 2) | 0 | Direct |
57850,88697
57850 - RING/U-box
88697 - PUA domain-like | 0 | Direct |
57889,48350
57889 - Cysteine-rich domain
48350 - GTPase activation domain, GAP | 0 | Direct |
81606,81601
81606 - PP2C-like
81601 - Protein serine/threonine phosphatase 2C, C-terminal domain | 0 | Direct |
56112,50729
56112 - Protein kinase-like (PK-like)
50729 - PH domain-like | 0 | Direct |
48366,47473
48366 - Ras GEF
47473 - EF-hand | 0 | Direct |
57196,57535
57196 - EGF/Laminin
57535 - Complement control module/SCR domain | 0 | Direct |
51905,55424
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
57184,49265
57184 - Growth factor receptor domain
49265 - Fibronectin type III | 0 | Direct |
57414,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like | 0 | Direct |
103575,81296
103575 - Plexin repeat
81296 - E set domains | 0 | Direct |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0 | Direct |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | Direct |
56091,50249
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | Direct |
63501,50242
63501 - Frizzled cysteine-rich domain
50242 - TIMP-like | 0 | Direct |
50447,-8
50447 - Translation proteins
-8 - ECOD | 0 | Direct |
53300,81995
53300 - vWA-like
81995 - beta-sandwich domain of Sec23/24 | 0 | Direct |
48371,101447
48371 - ARM repeat
101447 - Formin homology 2 domain (FH2 domain) | 0 | Direct |
161093,161093
161093 - MgtE membrane domain-like
161093 - MgtE membrane domain-like | 0 | Direct |
47668,47473
47668 - N-terminal domain of cbl (N-cbl)
47473 - EF-hand | 0 | Direct |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.0002173 | Direct |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.0002865 | Direct |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0.0003454 | Direct |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.001412 | Inherited |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.001628 | Inherited |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.002231 | Inherited |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.005727 | Inherited |
52821,52799
52821 - Rhodanese/Cell cycle control phosphatase
52799 - (Phosphotyrosine protein) phosphatases II | 0.01274 | Inherited |
101912,103575
101912 - Sema domain
103575 - Plexin repeat | 0.01367 | Inherited |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0.01854 | Inherited |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.01991 | Inherited |
54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 0.01991 | Inherited |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0.01991 | Inherited |
57889,57889
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0.02548 | Inherited |
69318,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0.02575 | Inherited |
69179,69179
69179 - Integrin domains
69179 - Integrin domains | 0.02575 | Inherited |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 0.03312 | Inherited |
81296,81296
81296 - E set domains
81296 - E set domains | 0.04494 | Inherited |
50729,81837
50729 - PH domain-like
81837 - BEACH domain | 0.04724 | Inherited |
55550,158235
55550 - SH2 domain
158235 - SOCS box-like | 0.04724 | Inherited |
54791,54791
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I) | 0.05174 | Inherited |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0.06078 | Inherited |
57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0.06925 | Inherited |
57196,69687
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0.0718 | Inherited |
53300,69179
53300 - vWA-like
69179 - Integrin domains | 0.0718 | Inherited |
103473,100895
103473 - MFS general substrate transporter
100895 - Kazal-type serine protease inhibitors | 0.07623 | Inherited |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.07963 | Inherited |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.08095 | Inherited |
52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.1069 | Inherited |
52540,48340
52540 - P-loop containing nucleoside triphosphate hydrolases
48340 - Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain | 0.1072 | Inherited |
57630,57196
57630 - GLA-domain
57196 - EGF/Laminin | 0.108 | Inherited |
52540,48019
52540 - P-loop containing nucleoside triphosphate hydrolases
48019 - post-AAA+ oligomerization domain-like | 0.108 | Inherited |
47095,47095
47095 - HMG-box
47095 - HMG-box | 0.108 | Inherited |
48371,48371
48371 - ARM repeat
48371 - ARM repeat | 0.1475 | Inherited |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.1486 | Inherited |
53300,69318
53300 - vWA-like
69318 - Integrin alpha N-terminal domain | 0.1486 | Inherited |
64268,103657
64268 - PX domain
103657 - BAR/IMD domain-like | 0.1604 | Inherited |
49503,49503
49503 - Cupredoxins
49503 - Cupredoxins | 0.1604 | Inherited |
49899,52540
49899 - Concanavalin A-like lectins/glucanases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1604 | Inherited |
47454,57959
47454 - A DNA-binding domain in eukaryotic transcription factors
57959 - Leucine zipper domain | 0.1791 | Inherited |
49785,49785
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like | 0.2036 | Inherited |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0.2036 | Inherited |
56487,56487
56487 - SRCR-like
56487 - SRCR-like | 0.2214 | Inherited |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0.2214 | Inherited |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0.2214 | Inherited |
111418,81321
111418 - Hormone receptor domain
81321 - Family A G protein-coupled receptor-like | 0.2281 | Inherited |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0.2303 | Inherited |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.3043 | Inherited |
55486,57552
55486 - Metalloproteases ("zincins"), catalytic domain
57552 - Blood coagulation inhibitor (disintegrin) | 0.3239 | Inherited |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.3546 | Inherited |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.3624 | Inherited |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.4068 | Inherited |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.8661 | Inherited |
47986,52540
47986 - DEATH domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.9638 | Inherited |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Triple) in N- to C-terminal order( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
142921,47587,56399
142921 - WGR domain-like
47587 - Domain of poly(ADP-ribose) polymerase
56399 - ADP-ribosylation | 0 | DIRECT |
48726,82895,82895
48726 - Immunoglobulin
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
51045,51045,51045
51045 - WW domain
51045 - WW domain
51045 - WW domain | 0 | DIRECT |
57414,57440,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like
57440 - Kringle-like | 0 | DIRECT |
50729,57889,57889
50729 - PH domain-like
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0 | DIRECT |
53067,100920,100934
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
52540,52540,46785
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
57440,56436,56436
57440 - Kringle-like
56436 - C-type lectin-like
56436 - C-type lectin-like | 0 | DIRECT |
57196,57535,57535
57196 - EGF/Laminin
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | DIRECT |
82199,57667,57667
82199 - SET domain
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0 | DIRECT |
57184,57196,57184
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | DIRECT |
103637,103637,103637
103637 - CCHHC domain
103637 - CCHHC domain
103637 - CCHHC domain | 0 | DIRECT |
49265,49265,53300
49265 - Fibronectin type III
49265 - Fibronectin type III
53300 - vWA-like | 0 | DIRECT |
57196,57581,57196
57196 - EGF/Laminin
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0 | DIRECT |
56436,56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like
56436 - C-type lectin-like | 0 | DIRECT |
49785,57184,49265
49785 - Galactose-binding domain-like
57184 - Growth factor receptor domain
49265 - Fibronectin type III | 0 | DIRECT |
55486,49854,49854
55486 - Metalloproteases ("zincins"), catalytic domain
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
57196,57196,90193
57196 - EGF/Laminin
57196 - EGF/Laminin
90193 - Notch domain | 0 | DIRECT |
47668,47473,55550
47668 - N-terminal domain of cbl (N-cbl)
47473 - EF-hand
55550 - SH2 domain | 0 | DIRECT |
50729,50729,48350
50729 - PH domain-like
50729 - PH domain-like
48350 - GTPase activation domain, GAP | 0 | DIRECT |
100895,47473,57610
100895 - Kazal-type serine protease inhibitors
47473 - EF-hand
57610 - Thyroglobulin type-1 domain | 0 | DIRECT |
52058,49265,49265
52058 - L domain-like
49265 - Fibronectin type III
49265 - Fibronectin type III | 0 | DIRECT |
47473,55550,57850
47473 - EF-hand
55550 - SH2 domain
57850 - RING/U-box | 0 | DIRECT |
48366,47473,57889
48366 - Ras GEF
47473 - EF-hand
57889 - Cysteine-rich domain | 0 | DIRECT |
53300,81995,81811
53300 - vWA-like
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24 | 0 | DIRECT |
63763,57903,47370
63763 - SAND domain-like
57903 - FYVE/PHD zinc finger
47370 - Bromodomain | 0 | DIRECT |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
50729,81837,50978
50729 - PH domain-like
81837 - BEACH domain
50978 - WD40 repeat-like | 0 | DIRECT |
57924,57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0 | DIRECT |
47986,47986,52129
47986 - DEATH domain
47986 - DEATH domain
52129 - Caspase-like | 0 | DIRECT |
50447,-8,54980
50447 - Translation proteins
-8 - ECOD
54980 - EF-G C-terminal domain-like | 0 | DIRECT |
53067,53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0 | DIRECT |
57863,50729,50729
57863 - ArfGap/RecO-like zinc finger
50729 - PH domain-like
50729 - PH domain-like | 0 | DIRECT |
81995,81811,82754
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
57586,57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like
57586 - TNF receptor-like | 0 | DIRECT |
117018,56091,50249
117018 - ATP-dependent DNA ligase DNA-binding domain
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | DIRECT |
57850,48452,57850
57850 - RING/U-box
48452 - TPR-like
57850 - RING/U-box | 0 | DIRECT |
63748,82199,57903
63748 - Tudor/PWWP/MBT
82199 - SET domain
57903 - FYVE/PHD zinc finger | 0 | DIRECT |
50370,57440,56436
50370 - Ricin B-like lectins
57440 - Kringle-like
56436 - C-type lectin-like | 0 | DIRECT |
47576,48065,50729
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0 | DIRECT |
90188,90188,53649
90188 - Somatomedin B domain
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like | 0 | DIRECT |
103575,81296,81296
103575 - Plexin repeat
81296 - E set domains
81296 - E set domains | 0 | DIRECT |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0 | DIRECT |
47473,47473,47473
47473 - EF-hand
47473 - EF-hand
47473 - EF-hand | 0 | DIRECT |
57889,57889,49562
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
49562,57889,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0 | DIRECT |
63748,57903,57903
63748 - Tudor/PWWP/MBT
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0 | DIRECT |
48065,50729,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like
50729 - PH domain-like | 0 | DIRECT |
48452,57850,88697
48452 - TPR-like
57850 - RING/U-box
88697 - PUA domain-like | 0 | DIRECT |
57903,63748,82199
57903 - FYVE/PHD zinc finger
63748 - Tudor/PWWP/MBT
82199 - SET domain | 0 | DIRECT |
57184,52058,49265
57184 - Growth factor receptor domain
52058 - L domain-like
49265 - Fibronectin type III | 0 | DIRECT |
50729,49562,48350
50729 - PH domain-like
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48350 - GTPase activation domain, GAP | 0 | DIRECT |
50729,50729,57863
50729 - PH domain-like
50729 - PH domain-like
57863 - ArfGap/RecO-like zinc finger | 0 | DIRECT |
69179,69179,69179
69179 - Integrin domains
69179 - Integrin domains
69179 - Integrin domains | 0.01164 | INHERITED FROM: Gonadal Hormones || Progesterone || Progesterone Congeners || Corpus Luteum Hormones |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.01991 | INHERITED FROM: Enzyme Inhibitors |
69318,69179,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains
69179 - Integrin domains | 0.02575 | INHERITED FROM: Progesterone || Progesterone Congeners || Corpus Luteum Hormones |
48371,48371,48371
48371 - ARM repeat
48371 - ARM repeat
48371 - ARM repeat | 0.03082 | INHERITED FROM: Molecular Mechanisms of Pharmacological Action || Enzyme Inhibitors |
57196,57196,69687
57196 - EGF/Laminin
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0.0718 | INHERITED FROM: Progesterone || Progesterone Congeners || Corpus Luteum Hormones |
54791,54791,54791
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I) | 0.0718 | INHERITED FROM: Molecular Mechanisms of Pharmacological Action || Enzyme Inhibitors |
57440,57440,50494
57440 - Kringle-like
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.108 | INHERITED FROM: ethinyl estradiol-desogestrel combination || Progesterone || Estrogenic Steroids, Alkylated || Medroxyprogesterone || Medroxyprogesterone Acetate |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.1392 | INHERITED FROM: Matrix Metalloproteinase Inhibitors || Estradiol Congeners || Protease Inhibitors || Estradiol |
56487,56487,56487
56487 - SRCR-like
56487 - SRCR-like
56487 - SRCR-like | 0.1486 | INHERITED FROM: Progesterone || Progesterone Congeners || Medroxyprogesterone || Corpus Luteum Hormones || Medroxyprogesterone Acetate |
53300,69318,69179
53300 - vWA-like
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0.1486 | INHERITED FROM: Progesterone || Progesterone Congeners || Medroxyprogesterone || Corpus Luteum Hormones || Medroxyprogesterone Acetate |
52833,52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.1791 | INHERITED FROM: Dihydrotestosterone |
47459,55785,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.2036 | INHERITED FROM: Thyroxine || Fulvestrant || Thyroid Hormones || testosterone-3-carboxymethyloxime-bovine serum albumin conjugate || Thyronines || Triiodothyronine || 17-Ketosteroids || Adrenal Cortex Hormones |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.2214 | INHERITED FROM: Molecular Mechanisms of Pharmacological Action || Enzyme Inhibitors |
49503,49503,49503
49503 - Cupredoxins
49503 - Cupredoxins
49503 - Cupredoxins | 0.2364 | INHERITED FROM: Testosterone |
100895,100895,100895
100895 - Kazal-type serine protease inhibitors
100895 - Kazal-type serine protease inhibitors
100895 - Kazal-type serine protease inhibitors | 0.2364 | INHERITED FROM: Progesterone || Progesterone Congeners || Corpus Luteum Hormones |
57440,57440,57440
57440 - Kringle-like
57440 - Kringle-like
57440 - Kringle-like | 0.2749 | INHERITED FROM: Medroxyprogesterone || Medroxyprogesterone Acetate |
47769,47769,47769
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain | 0.3646 | INHERITED FROM: Dihydrotestosterone |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
142921,47587,56399
142921 - WGR domain-like
47587 - Domain of poly(ADP-ribose) polymerase
56399 - ADP-ribosylation | 0 | Direct |
48726,82895,82895
48726 - Immunoglobulin
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | Direct |
51045,51045,51045
51045 - WW domain
51045 - WW domain
51045 - WW domain | 0 | Direct |
57414,57440,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like
57440 - Kringle-like | 0 | Direct |
50729,57889,57889
50729 - PH domain-like
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0 | Direct |
53067,100920,100934
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
52540,52540,46785
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
57440,56436,56436
57440 - Kringle-like
56436 - C-type lectin-like
56436 - C-type lectin-like | 0 | Direct |
57196,57535,57535
57196 - EGF/Laminin
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | Direct |
82199,57667,57667
82199 - SET domain
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0 | Direct |
57184,57196,57184
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | Direct |
103637,103637,103637
103637 - CCHHC domain
103637 - CCHHC domain
103637 - CCHHC domain | 0 | Direct |
49265,49265,53300
49265 - Fibronectin type III
49265 - Fibronectin type III
53300 - vWA-like | 0 | Direct |
57196,57581,57196
57196 - EGF/Laminin
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0 | Direct |
56436,56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like
56436 - C-type lectin-like | 0 | Direct |
49785,57184,49265
49785 - Galactose-binding domain-like
57184 - Growth factor receptor domain
49265 - Fibronectin type III | 0 | Direct |
55486,49854,49854
55486 - Metalloproteases ("zincins"), catalytic domain
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain | 0 | Direct |
57196,57196,90193
57196 - EGF/Laminin
57196 - EGF/Laminin
90193 - Notch domain | 0 | Direct |
47668,47473,55550
47668 - N-terminal domain of cbl (N-cbl)
47473 - EF-hand
55550 - SH2 domain | 0 | Direct |
50729,50729,48350
50729 - PH domain-like
50729 - PH domain-like
48350 - GTPase activation domain, GAP | 0 | Direct |
100895,47473,57610
100895 - Kazal-type serine protease inhibitors
47473 - EF-hand
57610 - Thyroglobulin type-1 domain | 0 | Direct |
52058,49265,49265
52058 - L domain-like
49265 - Fibronectin type III
49265 - Fibronectin type III | 0 | Direct |
47473,55550,57850
47473 - EF-hand
55550 - SH2 domain
57850 - RING/U-box | 0 | Direct |
48366,47473,57889
48366 - Ras GEF
47473 - EF-hand
57889 - Cysteine-rich domain | 0 | Direct |
53300,81995,81811
53300 - vWA-like
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24 | 0 | Direct |
63763,57903,47370
63763 - SAND domain-like
57903 - FYVE/PHD zinc finger
47370 - Bromodomain | 0 | Direct |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | Direct |
50729,81837,50978
50729 - PH domain-like
81837 - BEACH domain
50978 - WD40 repeat-like | 0 | Direct |
57924,57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0 | Direct |
47986,47986,52129
47986 - DEATH domain
47986 - DEATH domain
52129 - Caspase-like | 0 | Direct |
50447,-8,54980
50447 - Translation proteins
-8 - ECOD
54980 - EF-G C-terminal domain-like | 0 | Direct |
53067,53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0 | Direct |
57863,50729,50729
57863 - ArfGap/RecO-like zinc finger
50729 - PH domain-like
50729 - PH domain-like | 0 | Direct |
81995,81811,82754
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
57586,57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like
57586 - TNF receptor-like | 0 | Direct |
117018,56091,50249
117018 - ATP-dependent DNA ligase DNA-binding domain
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | Direct |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | Direct |
57850,48452,57850
57850 - RING/U-box
48452 - TPR-like
57850 - RING/U-box | 0 | Direct |
63748,82199,57903
63748 - Tudor/PWWP/MBT
82199 - SET domain
57903 - FYVE/PHD zinc finger | 0 | Direct |
50370,57440,56436
50370 - Ricin B-like lectins
57440 - Kringle-like
56436 - C-type lectin-like | 0 | Direct |
47576,48065,50729
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0 | Direct |
90188,90188,53649
90188 - Somatomedin B domain
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like | 0 | Direct |
103575,81296,81296
103575 - Plexin repeat
81296 - E set domains
81296 - E set domains | 0 | Direct |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0 | Direct |
47473,47473,47473
47473 - EF-hand
47473 - EF-hand
47473 - EF-hand | 0 | Direct |
57889,57889,49562
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
49562,57889,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0 | Direct |
63748,57903,57903
63748 - Tudor/PWWP/MBT
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0 | Direct |
48065,50729,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like
50729 - PH domain-like | 0 | Direct |
48452,57850,88697
48452 - TPR-like
57850 - RING/U-box
88697 - PUA domain-like | 0 | Direct |
57903,63748,82199
57903 - FYVE/PHD zinc finger
63748 - Tudor/PWWP/MBT
82199 - SET domain | 0 | Direct |
57184,52058,49265
57184 - Growth factor receptor domain
52058 - L domain-like
49265 - Fibronectin type III | 0 | Direct |
50729,49562,48350
50729 - PH domain-like
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48350 - GTPase activation domain, GAP | 0 | Direct |
50729,50729,57863
50729 - PH domain-like
50729 - PH domain-like
57863 - ArfGap/RecO-like zinc finger | 0 | Direct |
69179,69179,69179
69179 - Integrin domains
69179 - Integrin domains
69179 - Integrin domains | 0.01164 | Inherited |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.01991 | Inherited |
69318,69179,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains
69179 - Integrin domains | 0.02575 | Inherited |
48371,48371,48371
48371 - ARM repeat
48371 - ARM repeat
48371 - ARM repeat | 0.03082 | Inherited |
57196,57196,69687
57196 - EGF/Laminin
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0.0718 | Inherited |
54791,54791,54791
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I) | 0.0718 | Inherited |
57440,57440,50494
57440 - Kringle-like
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.108 | Inherited |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.1392 | Inherited |
56487,56487,56487
56487 - SRCR-like
56487 - SRCR-like
56487 - SRCR-like | 0.1486 | Inherited |
53300,69318,69179
53300 - vWA-like
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0.1486 | Inherited |
52833,52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.1791 | Inherited |
47459,55785,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.2036 | Inherited |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.2214 | Inherited |
49503,49503,49503
49503 - Cupredoxins
49503 - Cupredoxins
49503 - Cupredoxins | 0.2364 | Inherited |
100895,100895,100895
100895 - Kazal-type serine protease inhibitors
100895 - Kazal-type serine protease inhibitors
100895 - Kazal-type serine protease inhibitors | 0.2364 | Inherited |
57440,57440,57440
57440 - Kringle-like
57440 - Kringle-like
57440 - Kringle-like | 0.2749 | Inherited |
47769,47769,47769
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain | 0.3646 | Inherited |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Plot distribution on species Tree Of Life (sTOL) for Superfamily and/or Family domains annotated by this CC term
 |
Plot tree as:
| |
Download Newick format tree:
|
( show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Plot distribution on species Tree Of Life (sTOL) for single supra-domains annotated by this CC term
|
Plot tree as:
| |
Download Newick format tree:
| |
Browsing in TREE OF LIFE:
|
( show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
|
|
> BO Hierarchy > Chemical Actions and Uses
