|
|
CTD Chemicals (CC): Acids, Carbocyclic 
(show info)
Biomedical Ontology
Like Gene Ontology (GO), biomedical ontology such as phenotype ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Biomedical ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI’s thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology Based on YP which is the major contributor to the ‘Ascomycete phenotype ontology’, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- UniProtKB KeyWords (KW) Ontology Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- CTD Diseases (CD) Ontology CD is MEDIC disease vocabulary that is modified by CTD from the "Diseases" [C] branch of Medical Subject Headings (MeSH), combined with genetic disorders from the Online Mendelian Inheritance in OMIM database.
- CTD Chemicals (CC) Ontology CC is chemical vocabulary that is adapted by CTD from the "Chemicals and Drugs" category and Supplementary Concept Records of Medical Subject Headings (MeSH, a hierarchical vocabulary used to index articles for MEDLINE/PubMed).
Jump to [ Top · Hierarchy · Annotations ]
Root: CC Hierarchy (CTD chemicals from Comparative Toxicogenomics Database)
Jump to [ Top · Hierarchy ]
Superfamily( show details)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| Di-copper centre-containing domain | 0 | DIRECT |
| beta-lactamase/transpeptidase-like | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| N-(deoxy)ribosyltransferase-like | 0 | DIRECT |
| Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
| LCCL domain | 0 | DIRECT |
| Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
| MAPEG domain-like | 0 | DIRECT |
| MOSC N-terminal domain-like | 0 | DIRECT |
| P-domain of calnexin/calreticulin | 0 | DIRECT |
| AhpD-like | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| Nicotinate/Quinolinate PRTase C-terminal domain-like | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | DIRECT |
| TB module/8-cys domain | 0 | DIRECT |
| Assembly domain of cartilage oligomeric matrix protein | 0 | DIRECT |
| TSP type-3 repeat | 0 | DIRECT |
| FAD-linked oxidases, C-terminal domain | 0 | DIRECT |
| BSD domain-like | 0 | DIRECT |
| Integrin beta tail domain | 0 | DIRECT |
| N-terminal domain of cbl (N-cbl) | 0 | DIRECT |
| Fibrinogen coiled-coil and central regions | 0 | DIRECT |
| Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | DIRECT |
| Proton glutamate symport protein | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| Connexin43 | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Small-conductance potassium channel | 0 | DIRECT |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
| RILP dimerisation region | 0 | DIRECT |
| Phosphoglucomutase, first 3 domains | 0 | DIRECT |
| Growth factor receptor domain | 0.000001035 | DIRECT |
| EGF/Laminin | 0.000005695 | DIRECT |
| Cytochrome P450 | 0.00000734 | DIRECT |
| Protein kinase-like (PK-like) | 0.00001546 | DIRECT |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.00003236 | DIRECT |
| Leucine zipper domain | 0.00005173 | DIRECT |
| Fibronectin type III | 0.00006498 | DIRECT |
| Nuclear receptor ligand-binding domain | 0.0001596 | DIRECT |
| Integrin domains | 0.0001845 | DIRECT |
| A DNA-binding domain in eukaryotic transcription factors | 0.0002387 | DIRECT |
| SH2 domain | 0.0009603 | DIRECT |
| Metallothionein | 0.002585 | INHERITED FROM: Chloromercuribenzoates || Mercuribenzoates || Chlorobenzoates |
| Kringle-like | 0.003372 | INHERITED FROM: Hydroxybenzoates || Aspirin |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.008177 | INHERITED FROM: Phthalic Anhydrides || butylidenephthalide |
| Thyroglobulin type-1 domain | 0.009447 | INHERITED FROM: Chloromercuribenzoates |
| PYP-like sensor domain (PAS domain) | 0.0112 | INHERITED FROM: Hydroxybenzoates || Benzocaine || butylbenzyl phthalate || Benzoates || butamben || Aminobenzoates |
| Frizzled cysteine-rich domain | 0.01171 | INHERITED FROM: Diclofenac |
| Calcium-dependent phosphotriesterase | 0.0143 | INHERITED FROM: phenylacetic acid |
| E2F-DP heterodimerization region | 0.0143 | INHERITED FROM: Diclofenac || UF010 compound || Caffeic Acids || Cinnamates || Eugenol || Phenylacetates |
| HD-domain/PDEase-like | 0.01979 | INHERITED FROM: Cilomilast || Cyclohexanecarboxylic Acids || Roflumilast || Benzamides |
| p53-like transcription factors | 0.02099 | INHERITED FROM: Anacardic Acids || Diclofenac || Iodobenzoates || Iopamidol || Cinnamates || Imatinib Mesylate || Triiodobenzoic Acids |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.02459 | INHERITED FROM: Phenylbutyrates || aurin || Chloromercuribenzoates || 4-phenylbutyric acid || Cyclohexanecarboxylic Acids |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.02459 | INHERITED FROM: Phenylbutyrates || aurin || Chloromercuribenzoates || 4-phenylbutyric acid || Cyclohexanecarboxylic Acids |
| Caspase-like | 0.02583 | INHERITED FROM: carboxycinnamic acid bishydroxamide || propylparaben || Hydroxybenzoates || Anacardic Acids || Phenylbutyrates || Fenamates || Cinnamates || Phthalic Anhydrides || mono-(2-ethylhexyl)phthalate || Remoxipride || p-carboxymethylphenyl 1,1-bis(3'-indolyl)-1-(p-carboxymethylphenyl)methane || Bromobenzoates || Eugenol || butylidenephthalide || 3-bromoacetylamino benzoic acid ethyl ester || Aminobenzoates || NCX 4040 || 4-phenylbutyric acid || Phthalimides || Cyclohexanecarboxylic Acids || NCQ 344 || dehydroxymethylepoxyquinomicin || Phenylacetates || Imatinib Mesylate || Parabens |
| MHC antigen-recognition domain | 0.03164 | INHERITED FROM: entinostat || lumiracoxib || tamibarotene |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0.05135 | INHERITED FROM: VER-246608 || tamibarotene |
| HLH, helix-loop-helix DNA-binding domain | 0.05545 | INHERITED FROM: Benzocaine || butamben || 3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid |
| Zn-binding ribosomal proteins | 0.05594 | INHERITED FROM: 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Cinnamates |
| Metalloproteases ("zincins"), catalytic domain | 0.05892 | INHERITED FROM: PD 0325901 || 3-caffeoyl-4-dihydrocaffeoylquinic acid |
| TNF receptor-like | 0.07697 | INHERITED FROM: Ibuprofen || Hydroxybenzoates || 4-(3-(1-adamantyl)-4-hydroxyphenyl)-3-chlorocinnamic acid || Parabens |
| 14-3-3 protein | 0.0866 | INHERITED FROM: Diclofenac || Aspirin |
| KA1-like | 0.0866 | INHERITED FROM: Dibutyl Phthalate |
| STAT | 0.0866 | INHERITED FROM: Diclofenac || Cinnamates || Eugenol || Aspirin || Phenylacetates |
| Transcription factor STAT-4 N-domain | 0.0866 | INHERITED FROM: Diclofenac || Cinnamates || Eugenol || Aspirin || Phenylacetates |
| DEATH domain | 0.08797 | INHERITED FROM: carboxycinnamic acid bishydroxamide || propylparaben || Hydroxybenzoates || Anacardic Acids || caffeic acid phenethyl ester || Diclofenac || 4-(3-(1-adamantyl)-4-hydroxyphenyl)-3-chlorocinnamic acid || Phthalimides || dehydroxymethylepoxyquinomicin || Imatinib Mesylate || Parabens |
| Kazal-type serine protease inhibitors | 0.09007 | INHERITED FROM: Diphenylacetic Acids || trospium chloride || Benzilates |
| Immunoglobulin | 0.09591 | INHERITED FROM: lumiracoxib || HX 630 || Lenalidomide |
| NAD(P)-linked oxidoreductase | 0.1097 | INHERITED FROM: Benzoic Acid || Flufenamic Acid || Ibuprofen || Hydroxybenzoates || octyl gallate || caffeic acid phenethyl ester || 4-hydroxybenzoic acid || Fenamates || Phenylpropionates || Caffeic Acids || Cinnamates || Meclofenamic Acid || Aminobenzoates || isoeugenol || 3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid || methyl salicylate || fenamic acid |
| GST C-terminal domain-like | 0.1112 | INHERITED FROM: ortho-Aminobenzoates || Fenamates || Diclofenac || apple polyphenol extract || methyleugenol || Aminobenzoates |
| Bcl-2 inhibitors of programmed cell death | 0.12 | INHERITED FROM: carboxycinnamic acid bishydroxamide || propylparaben || Hydroxybenzoates || ortho-Aminobenzoates || Fenamates || Iodobenzoates || atranorin || Cinnamates || Hydrolyzable Tannins || Puromycin || Aminobenzoates || BP-1-102 || gyrophoric acid || Aspirin || methyl caffeate || Phenylacetates || Imatinib Mesylate || Parabens || Triiodobenzoic Acids |
| Arginase/deacetylase | 0.1464 | INHERITED FROM: mocetinostat |
| MFS general substrate transporter | 0.1587 | INHERITED FROM: Hippurates || 5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methylbenzoic acid || Bumetanide || Fenamates || Ketoprofen || Salicylic Acid || Phenylpropionates || Diphenylacetic Acids || trospium chloride || Benzilates || p-Aminohippuric Acid || Sulpiride || Aminobenzoates || Aminohippuric Acids |
| NAD(P)-binding Rossmann-fold domains | 0.1808 | INHERITED FROM: Fenoprofen || DEET || methyl salicylate |
| Nucleic acid-binding proteins | 0.1987 | INHERITED FROM: 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Quinic Acid |
| Cyclin-like | 0.2181 | INHERITED FROM: Ro 41-5253 || Hydroxybenzoates || Diclofenac || UF010 compound || 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid || butylidenephthalide || Parabens |
| Inhibitor of apoptosis (IAP) repeat | 0.2339 | INHERITED FROM: Hydroxybenzoates || Anacardic Acids || caffeic acid phenethyl ester || Caffeic Acids || dehydroxymethylepoxyquinomicin |
| Alpha-macroglobulin receptor domain | 0.2544 | INHERITED FROM: Phthalic Acids |
| YWTD domain | 0.2563 | INHERITED FROM: Ibuprofen |
| (Phosphotyrosine protein) phosphatases II | 0.2681 | INHERITED FROM: ortho-Aminobenzoates || 2-(oxalylamino)benzoic acid || Aminobenzoates |
| HSP90 C-terminal domain | 0.2753 | INHERITED FROM: Cinnamates |
| DnaJ/Hsp40 cysteine-rich domain | 0.2753 | INHERITED FROM: Diclofenac || Phenylacetates |
| RNA-binding domain, RBD | 0.2793 | INHERITED FROM: butylidenephthalide |
| "Winged helix" DNA-binding domain | 0.2881 | INHERITED FROM: UF010 compound |
| Thioredoxin-like | 0.2889 | INHERITED FROM: ortho-Aminobenzoates || Fenamates || o-Phthalaldehyde || Quinic Acid |
| ABC transporter transmembrane region | 0.29 | INHERITED FROM: Bezafibrate || Imatinib Mesylate |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.3133 | INHERITED FROM: Caffeic Acids || Eugenol || isoeugenol |
| Annexin | 0.3206 | INHERITED FROM: Ibuprofen || Phenylpropionates |
| FAD/NAD(P)-binding domain | 0.3411 | INHERITED FROM: isoeugenol || Nitrobenzoates |
| Interleukin 8-like chemokines | 0.3549 | INHERITED FROM: Hydroxybenzoates || Cinnamates || Hydrolyzable Tannins || sirtinol || roflumilast N-oxide || Puromycin || Roflumilast || Imatinib Mesylate |
| HSP40/DnaJ peptide-binding domain | 0.4047 | INHERITED FROM: Diclofenac || Phenylacetates |
| Flavoproteins | 0.4047 | INHERITED FROM: Benzoic Acid || Hydroxybenzoates || ortho-Aminobenzoates || Fenamates || Aminobenzoates || Salicylates || Aspirin |
| Sm-like ribonucleoproteins | 0.415 | INHERITED FROM: 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid |
| PGBD-like | 0.4337 | INHERITED FROM: 3-caffeoyl-4-dihydrocaffeoylquinic acid || Chlorogenic Acid || Cyclohexanecarboxylic Acids |
| Voltage-gated potassium channels | 0.4495 | INHERITED FROM: Flufenamic Acid || Niflumic Acid |
| Tubulin C-terminal domain-like | 0.4526 | INHERITED FROM: Diclofenac |
| Chaperone J-domain | 0.4642 | INHERITED FROM: Diclofenac || Phenylacetates |
| FYVE/PHD zinc finger | 0.4743 | INHERITED FROM: 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide |
| Hemopexin-like domain | 0.524 | INHERITED FROM: 3-caffeoyl-4-dihydrocaffeoylquinic acid || Chlorogenic Acid |
| Tubulin nucleotide-binding domain-like | 0.5402 | INHERITED FROM: Diclofenac |
| Cystine-knot cytokines | 0.5407 | INHERITED FROM: MOPP protocol || Procarbazine |
| S15/NS1 RNA-binding domain | 0.6101 | INHERITED FROM: C646 compound |
| UDP-Glycosyltransferase/glycogen phosphorylase | 0.6485 | INHERITED FROM: ferulic acid || Coumaric Acids || ortho-Aminobenzoates || Fenamates || Diclofenac || Ketoprofen || diphenylacetic acid || Salicylic Acid || Phenylpropionates || Diphenylacetic Acids || Cinnamates || Fenoprofen || 3-phenylpropionic acid || hydratropic acid || mono-(2-ethylhexyl)phthalate || Vanillic Acid || Aminobenzoates || biphenylylacetic acid || Cyclohexanecarboxylic Acids || cinnamic acid || Indoprofen || methyl salicylate || Hydroxybenzoate Ethers || Diflunisal || Phenylacetates |
| SMAD/FHA domain | 0.6902 | INHERITED FROM: sirtinol |
| TNF-like | 0.6992 | INHERITED FROM: Bezafibrate |
| Actin-like ATPase domain | 0.7163 | INHERITED FROM: Phenylbutyrates || aurin || 4-phenylbutyric acid |
| ValRS/IleRS/LeuRS editing domain | 0.7283 | INHERITED FROM: Ibuprofen || Phenylpropionates |
| 4-helical cytokines | 0.7502 | INHERITED FROM: Ro 41-5253 || Sodium Salicylate || FK 706 || Hydroxybenzoates || Cilomilast || Aminobenzoates || Phthalimides || Cyclohexanecarboxylic Acids || 4'-hydroxydiclofenac || Phenylacetates |
| Nucleotidylyl transferase | 0.7886 | INHERITED FROM: Ibuprofen || Phenylpropionates |
| DHS-like NAD/FAD-binding domain | 0.824 | INHERITED FROM: diisononyl phthalate |
| Translation proteins SH3-like domain | 0.8367 | INHERITED FROM: 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid |
| GroEL-intermediate domain like | 0.8401 | INHERITED FROM: 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid |
| Lipocalins | 0.8904 | INHERITED FROM: Bezafibrate |
| SCOP hierarchy in SUPERFAMILY | 0.8984 | INHERITED FROM: Phenylbutyrates || 4-phenylbutyric acid |
| Prefoldin | 0.9035 | INHERITED FROM: ethyl-p-((E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-1-propenyl)benzoic acid |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.962 | INHERITED FROM: Ibuprofen || Phenylpropionates |
| GroEL equatorial domain-like | 0.9625 | INHERITED FROM: 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid |
| GroEL apical domain-like | 0.9625 | INHERITED FROM: 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid |
| Translation proteins | 0.9658 | INHERITED FROM: Phthalic Anhydrides || butylidenephthalide |
| Intermediate filament protein, coiled coil region | 0.9919 | INHERITED FROM: ethyl-p-((E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-1-propenyl)benzoic acid |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.9931 | INHERITED FROM: benzamide || 4-chloro-N-(2-(2-thienyl)imidazo(1,2-a)pyridin-3-yl)benzamide |
| Nicotinic receptor ligand binding domain-like | 0.9931 | INHERITED FROM: benzamide || 4-chloro-N-(2-(2-thienyl)imidazo(1,2-a)pyridin-3-yl)benzamide |
| beta-beta-alpha zinc fingers | 1 | INHERITED FROM: pomalidomide |
| Quinoprotein alcohol dehydrogenase-like | 1 | INHERITED FROM: 4-phenylbutyric acid |
| Family A G protein-coupled receptor-like | 1 | INHERITED FROM: 5-(3-(3-hydroxyphenoxy)azetidin-1-yl)-5-methyl-2,2-diphenylhexanamide || 1-(8-bromobenzo(1,2-b;4,5-b')difuran-4-yl)-2-aminopropane || (N-N'-bis-(2-(1H-indol-3-yl)-ethyl)-N,N'-bis-(3-thiomorpholin-4-yl-propyl)-phthalamide) || Quinuclidinyl Benzilate |
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| Di-copper centre-containing domain | 0 | Direct |
| beta-lactamase/transpeptidase-like | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| N-(deoxy)ribosyltransferase-like | 0 | Direct |
| Phosphoglucomutase, C-terminal domain | 0 | Direct |
| LCCL domain | 0 | Direct |
| Cation efflux protein cytoplasmic domain-like | 0 | Direct |
| MAPEG domain-like | 0 | Direct |
| MOSC N-terminal domain-like | 0 | Direct |
| P-domain of calnexin/calreticulin | 0 | Direct |
| AhpD-like | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| Nicotinate/Quinolinate PRTase C-terminal domain-like | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | Direct |
| TB module/8-cys domain | 0 | Direct |
| Assembly domain of cartilage oligomeric matrix protein | 0 | Direct |
| TSP type-3 repeat | 0 | Direct |
| FAD-linked oxidases, C-terminal domain | 0 | Direct |
| BSD domain-like | 0 | Direct |
| Integrin beta tail domain | 0 | Direct |
| N-terminal domain of cbl (N-cbl) | 0 | Direct |
| Fibrinogen coiled-coil and central regions | 0 | Direct |
| Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | Direct |
| Proton glutamate symport protein | 0 | Direct |
| p53 tetramerization domain | 0 | Direct |
| Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
| Connexin43 | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Small-conductance potassium channel | 0 | Direct |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
| RILP dimerisation region | 0 | Direct |
| Phosphoglucomutase, first 3 domains | 0 | Direct |
| Growth factor receptor domain | 0.000001035 | Direct |
| EGF/Laminin | 0.000005695 | Direct |
| Cytochrome P450 | 0.00000734 | Direct |
| Protein kinase-like (PK-like) | 0.00001546 | Direct |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.00003236 | Direct |
| Leucine zipper domain | 0.00005173 | Direct |
| Fibronectin type III | 0.00006498 | Direct |
| Nuclear receptor ligand-binding domain | 0.0001596 | Direct |
| Integrin domains | 0.0001845 | Direct |
| A DNA-binding domain in eukaryotic transcription factors | 0.0002387 | Direct |
| SH2 domain | 0.0009603 | Direct |
| Metallothionein | 0.002585 | Inherited |
| Kringle-like | 0.003372 | Inherited |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.008177 | Inherited |
| Thyroglobulin type-1 domain | 0.009447 | Inherited |
| PYP-like sensor domain (PAS domain) | 0.0112 | Inherited |
| Frizzled cysteine-rich domain | 0.01171 | Inherited |
| Calcium-dependent phosphotriesterase | 0.0143 | Inherited |
| E2F-DP heterodimerization region | 0.0143 | Inherited |
| HD-domain/PDEase-like | 0.01979 | Inherited |
| p53-like transcription factors | 0.02099 | Inherited |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.02459 | Inherited |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.02459 | Inherited |
| Caspase-like | 0.02583 | Inherited |
| MHC antigen-recognition domain | 0.03164 | Inherited |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0.05135 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.05545 | Inherited |
| Zn-binding ribosomal proteins | 0.05594 | Inherited |
| Metalloproteases ("zincins"), catalytic domain | 0.05892 | Inherited |
| TNF receptor-like | 0.07697 | Inherited |
| 14-3-3 protein | 0.0866 | Inherited |
| KA1-like | 0.0866 | Inherited |
| STAT | 0.0866 | Inherited |
| Transcription factor STAT-4 N-domain | 0.0866 | Inherited |
| DEATH domain | 0.08797 | Inherited |
| Kazal-type serine protease inhibitors | 0.09007 | Inherited |
| Immunoglobulin | 0.09591 | Inherited |
| NAD(P)-linked oxidoreductase | 0.1097 | Inherited |
| GST C-terminal domain-like | 0.1112 | Inherited |
| Bcl-2 inhibitors of programmed cell death | 0.12 | Inherited |
| Arginase/deacetylase | 0.1464 | Inherited |
| MFS general substrate transporter | 0.1587 | Inherited |
| NAD(P)-binding Rossmann-fold domains | 0.1808 | Inherited |
| Nucleic acid-binding proteins | 0.1987 | Inherited |
| Cyclin-like | 0.2181 | Inherited |
| Inhibitor of apoptosis (IAP) repeat | 0.2339 | Inherited |
| Alpha-macroglobulin receptor domain | 0.2544 | Inherited |
| YWTD domain | 0.2563 | Inherited |
| (Phosphotyrosine protein) phosphatases II | 0.2681 | Inherited |
| HSP90 C-terminal domain | 0.2753 | Inherited |
| DnaJ/Hsp40 cysteine-rich domain | 0.2753 | Inherited |
| RNA-binding domain, RBD | 0.2793 | Inherited |
| "Winged helix" DNA-binding domain | 0.2881 | Inherited |
| Thioredoxin-like | 0.2889 | Inherited |
| ABC transporter transmembrane region | 0.29 | Inherited |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.3133 | Inherited |
| Annexin | 0.3206 | Inherited |
| FAD/NAD(P)-binding domain | 0.3411 | Inherited |
| Interleukin 8-like chemokines | 0.3549 | Inherited |
| HSP40/DnaJ peptide-binding domain | 0.4047 | Inherited |
| Flavoproteins | 0.4047 | Inherited |
| Sm-like ribonucleoproteins | 0.415 | Inherited |
| PGBD-like | 0.4337 | Inherited |
| Voltage-gated potassium channels | 0.4495 | Inherited |
| Tubulin C-terminal domain-like | 0.4526 | Inherited |
| Chaperone J-domain | 0.4642 | Inherited |
| FYVE/PHD zinc finger | 0.4743 | Inherited |
| Hemopexin-like domain | 0.524 | Inherited |
| Tubulin nucleotide-binding domain-like | 0.5402 | Inherited |
| Cystine-knot cytokines | 0.5407 | Inherited |
| S15/NS1 RNA-binding domain | 0.6101 | Inherited |
| UDP-Glycosyltransferase/glycogen phosphorylase | 0.6485 | Inherited |
| SMAD/FHA domain | 0.6902 | Inherited |
| TNF-like | 0.6992 | Inherited |
| Actin-like ATPase domain | 0.7163 | Inherited |
| ValRS/IleRS/LeuRS editing domain | 0.7283 | Inherited |
| 4-helical cytokines | 0.7502 | Inherited |
| Nucleotidylyl transferase | 0.7886 | Inherited |
| DHS-like NAD/FAD-binding domain | 0.824 | Inherited |
| Translation proteins SH3-like domain | 0.8367 | Inherited |
| GroEL-intermediate domain like | 0.8401 | Inherited |
| Lipocalins | 0.8904 | Inherited |
| SCOP hierarchy in SUPERFAMILY | 0.8984 | Inherited |
| Prefoldin | 0.9035 | Inherited |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.962 | Inherited |
| GroEL equatorial domain-like | 0.9625 | Inherited |
| GroEL apical domain-like | 0.9625 | Inherited |
| Translation proteins | 0.9658 | Inherited |
| Intermediate filament protein, coiled coil region | 0.9919 | Inherited |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.9931 | Inherited |
| Nicotinic receptor ligand binding domain-like | 0.9931 | Inherited |
| beta-beta-alpha zinc fingers | 1 | Inherited |
| Quinoprotein alcohol dehydrogenase-like | 1 | Inherited |
| Family A G protein-coupled receptor-like | 1 | Inherited |
LINKTO: Domain2BO Download and Domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Family( show details)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| Connexin43 | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | DIRECT |
| C5 cytosine-specific DNA methylase, DCM | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| Proton glutamate symport protein | 0 | DIRECT |
| Alkaline phosphatase | 0 | DIRECT |
| A20-like zinc finger | 0 | DIRECT |
| IP3 receptor type 1 binding core, domain 2 | 0 | DIRECT |
| 2'-5'-oligoadenylate synthetase 1, OAS1, second domain | 0 | DIRECT |
| Serine carboxypeptidase-like | 0 | DIRECT |
| Assembly domain of cartilage oligomeric matrix protein | 0 | DIRECT |
| MOSC N-terminal domain-like | 0 | DIRECT |
| Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
| DEATH effector domain, DED | 0 | DIRECT |
| MAPEG domain | 0 | DIRECT |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain | 0 | DIRECT |
| PAS domain of steroid receptor coactivator 1A, NCo-A1 | 0 | DIRECT |
| P-domain of calnexin/calreticulin | 0 | DIRECT |
| E2F dimerization segment | 0 | DIRECT |
| 2'-5'-oligoadenylate synthetase 1, OAS1, N-terminal domain | 0 | DIRECT |
| Platelet-derived growth factor-like | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| Fibrinogen coiled-coil and central regions | 0 | DIRECT |
| Tetrahydrofolate dehydrogenase/cyclohydrolase | 0 | DIRECT |
| Alpha-adaptin ear subdomain-like | 0 | DIRECT |
| Prohormone convertase 1 pro-domain | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, C-terminal domain | 0 | DIRECT |
| Small-conductance potassium channel | 0 | DIRECT |
| Integrin beta tail domain | 0 | DIRECT |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain | 0 | DIRECT |
| p53 DNA-binding domain-like | 0 | DIRECT |
| Cysteine rich domain | 0 | DIRECT |
| RILP dimerisation region | 0 | DIRECT |
| Transferrin | 0 | DIRECT |
| IMD domain | 0 | DIRECT |
| CAT-like | 0 | DIRECT |
| Adenylyltransferase | 0 | DIRECT |
| Phoshatidylinositol transfer protein, PITP | 0 | DIRECT |
| PUA domain | 0 | DIRECT |
| LCCL domain | 0 | DIRECT |
| Retinoblastoma tumor suppressor domains | 0 | DIRECT |
| Serum paraoxonase/arylesterase 1, PON1 | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Oligosaccharide phosphorylase | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| Hexokinase | 0 | DIRECT |
| Calnexin/calreticulin | 0 | DIRECT |
| Aminoacid dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| N-terminal domain of cbl (N-cbl) | 0 | DIRECT |
| TB module/8-cys domain | 0 | DIRECT |
| BSD domain | 0 | DIRECT |
| TSP type-3 repeat | 0 | DIRECT |
| Tissue inhibitor of metalloproteinases, TIMP | 0 | DIRECT |
| Integrin beta EGF-like domains | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| Clathrin adaptor appendage, alpha and beta chain-specific domain | 0 | DIRECT |
| Malic enzyme N-domain | 0 | DIRECT |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | DIRECT |
| SMAD domain | 0 | DIRECT |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
| Phosphoglucomutase, first 3 domains | 0 | DIRECT |
| HCDH C-domain-like | 0 | DIRECT |
| Thrombospondin C-terminal domain | 0 | DIRECT |
| Cytochrome P450 | 0.00001401 | DIRECT |
| DEATH domain, DD | 0.0000388 | DIRECT |
| Leucine zipper domain | 0.00006404 | DIRECT |
| Fibronectin type III | 0.0001302 | DIRECT |
| Growth factor receptor domain | 0.0001599 | DIRECT |
| Laminin G-like module | 0.0001626 | DIRECT |
| Protein kinases, catalytic subunit | 0.0001631 | DIRECT |
| Nuclear receptor ligand-binding domain | 0.0001927 | DIRECT |
| Integrin domains | 0.0001944 | DIRECT |
| A DNA-binding domain in eukaryotic transcription factors | 0.0002333 | DIRECT |
| Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain) | 0.0003831 | DIRECT |
| Nuclear receptor | 0.0003956 | DIRECT |
| EGF-type module | 0.001401 | INHERITED FROM: Benzoates || Chlorogenic Acid || Benzamides |
| SH2 domain | 0.001403 | INHERITED FROM: Diclofenac || tamibarotene || Phenylacetates || Imatinib Mesylate |
| Metallothionein | 0.002487 | INHERITED FROM: Chloromercuribenzoates || Mercuribenzoates || Chlorobenzoates |
| PDEase | 0.007754 | INHERITED FROM: Cilomilast || Cyclohexanecarboxylic Acids || Roflumilast || Benzamides |
| PAPS sulfotransferase | 0.008377 | INHERITED FROM: ortho-Aminobenzoates || Fenamates || caffeic acid || DEET |
| C1 set domains (antibody constant domain-like) | 0.008849 | INHERITED FROM: entinostat || lumiracoxib || tamibarotene |
| Thyroglobulin type-1 domain | 0.009426 | INHERITED FROM: Chloromercuribenzoates |
| Frizzled cysteine-rich domain | 0.01194 | INHERITED FROM: Diclofenac |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.02367 | INHERITED FROM: Phenylbutyrates || aurin || Chloromercuribenzoates || 4-phenylbutyric acid || Cyclohexanecarboxylic Acids |
| Glutathione S-transferase (GST), C-terminal domain | 0.02527 | INHERITED FROM: ortho-Aminobenzoates || Fenamates || Diclofenac || apple polyphenol extract || methyleugenol || Eugenol || Aminobenzoates || Phenylacetates |
| Ephrin receptor ligand binding domain | 0.03008 | INHERITED FROM: 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide |
| MHC antigen-recognition domain | 0.03436 | INHERITED FROM: entinostat || lumiracoxib || tamibarotene |
| Cell cycle transcription factor e2f-dp | 0.03447 | INHERITED FROM: Diclofenac || UF010 compound || Caffeic Acids || Cinnamates || Eugenol |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.0362 | INHERITED FROM: Phenylbutyrates || 4-phenylbutyric acid || Cyclohexanecarboxylic Acids |
| Caspase catalytic domain | 0.05872 | INHERITED FROM: carboxycinnamic acid bishydroxamide || propylparaben || Hydroxybenzoates || Anacardic Acids || Phenylbutyrates || Fenamates || Cinnamates || Phthalic Anhydrides || mono-(2-ethylhexyl)phthalate || Remoxipride || Niflumic Acid || p-carboxymethylphenyl 1,1-bis(3'-indolyl)-1-(p-carboxymethylphenyl)methane || Bromobenzoates || Eugenol || butylidenephthalide || Aminobenzoates || NCX 4040 || 4-phenylbutyric acid || Phthalimides || Cyclohexanecarboxylic Acids || NCQ 344 || dehydroxymethylepoxyquinomicin || Phenylacetates || Imatinib Mesylate || Parabens |
| Short-chain cytokines | 0.06182 | INHERITED FROM: Thalidomide || Diclofenac || Phthalic Anhydrides || Phthalimides || Cyclohexanecarboxylic Acids || pomalidomide |
| HLH, helix-loop-helix DNA-binding domain | 0.06923 | INHERITED FROM: Benzocaine || butamben || 3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid |
| Hypoxia-inducible factor Hif2a, C-terminal domain | 0.07975 | INHERITED FROM: Diclofenac || butylbenzyl phthalate |
| Proprotein convertase P-domain | 0.0822 | INHERITED FROM: Aspirin |
| STAT | 0.0822 | INHERITED FROM: Diclofenac || Cinnamates || Eugenol || Aspirin || Phenylacetates |
| 14-3-3 protein | 0.0822 | INHERITED FROM: Diclofenac || Aspirin |
| Transcription factor STAT-4 N-domain | 0.0822 | INHERITED FROM: Diclofenac || Cinnamates || Eugenol || Aspirin || Phenylacetates |
| STAT DNA-binding domain | 0.0822 | INHERITED FROM: Diclofenac || Cinnamates || Eugenol || Aspirin || Phenylacetates |
| Fibronectin type II module | 0.08635 | INHERITED FROM: mono-(2-ethylhexyl)phthalate |
| TBP-associated factors, TAFs | 0.09251 | INHERITED FROM: Diclofenac |
| ets domain | 0.09681 | INHERITED FROM: PD 0325901 |
| Glutathione S-transferase (GST), N-terminal domain | 0.1012 | INHERITED FROM: Mefenamic Acid || ortho-Aminobenzoates || Fenamates |
| TNF receptor-like | 0.1012 | INHERITED FROM: Ibuprofen || Hydroxybenzoates || Phenylpropionates || 4-(3-(1-adamantyl)-4-hydroxyphenyl)-3-chlorocinnamic acid || Aspirin || Parabens |
| Canonical RBD | 0.1027 | INHERITED FROM: butylidenephthalide |
| I set domains | 0.108 | INHERITED FROM: Lenalidomide |
| Aldo-keto reductases (NADP) | 0.1091 | INHERITED FROM: Benzoic Acid || Flufenamic Acid || Ibuprofen || Hydroxybenzoates || octyl gallate || caffeic acid phenethyl ester || 4-hydroxybenzoic acid || Fenamates || Phenylpropionates || Caffeic Acids || Cinnamates || Meclofenamic Acid || Aminobenzoates || isoeugenol || 3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid || methyl salicylate || fenamic acid |
| Bcl-2 inhibitors of programmed cell death | 0.1181 | INHERITED FROM: carboxycinnamic acid bishydroxamide || propylparaben || Hydroxybenzoates || ortho-Aminobenzoates || Fenamates || Iodobenzoates || atranorin || Cinnamates || Hydrolyzable Tannins || Puromycin || Aminobenzoates || BP-1-102 || gyrophoric acid || Aspirin || methyl caffeate || Phenylacetates || Imatinib Mesylate || Parabens || Triiodobenzoic Acids |
| Rel/Dorsal transcription factors, DNA-binding domain | 0.1213 | INHERITED FROM: caffeic acid phenethyl ester || Caffeic Acids |
| Histone deacetylase, HDAC | 0.1251 | INHERITED FROM: mocetinostat |
| Acetylcholinesterase-like | 0.1434 | INHERITED FROM: Aminobenzoates |
| Long-chain cytokines | 0.1434 | INHERITED FROM: Thalidomide || Hydroxybenzoates || Aminobenzoates |
| Pentraxin (pentaxin) | 0.1773 | INHERITED FROM: Phthalic Acids || Diethylhexyl Phthalate |
| Kinase associated domain 1, KA1 | 0.1796 | INHERITED FROM: Dibutyl Phthalate |
| a tRNA synthase domain | 0.1796 | INHERITED FROM: C646 compound |
| DNA polymerase I | 0.1873 | INHERITED FROM: Diclofenac |
| Fatty acid binding protein-like | 0.1997 | INHERITED FROM: Bezafibrate |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.1997 | INHERITED FROM: Hydroxybenzoates || butylparaben || Aspirin |
| Cyclin | 0.2066 | INHERITED FROM: Hydroxybenzoates || caffeic acid phenethyl ester || Diclofenac || 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid || Parabens |
| ABC transporter transmembrane region | 0.2078 | INHERITED FROM: Bezafibrate || Imatinib Mesylate |
| Inhibitor of apoptosis (IAP) repeat | 0.226 | INHERITED FROM: Hydroxybenzoates || Anacardic Acids || caffeic acid phenethyl ester || Caffeic Acids || dehydroxymethylepoxyquinomicin |
| S100 proteins | 0.2278 | INHERITED FROM: Phthalic Acids || Diethylhexyl Phthalate |
| Higher-molecular-weight phosphotyrosine protein phosphatases | 0.2327 | INHERITED FROM: ortho-Aminobenzoates || 2-(oxalylamino)benzoic acid || Aminobenzoates |
| Complement components | 0.2469 | INHERITED FROM: Phthalic Acids |
| C2 set domains | 0.2469 | INHERITED FROM: Hydroxybenzoates || Salicylates || Aspirin |
| Alpha-macroglobulin receptor domain | 0.2469 | INHERITED FROM: Phthalic Acids |
| YWTD domain | 0.2531 | INHERITED FROM: Ibuprofen |
| UDPGT-like | 0.2543 | INHERITED FROM: ferulic acid || Hydroxybenzoates || Diethylhexyl Phthalate || Coumaric Acids || ortho-Aminobenzoates || Fenamates || Diclofenac || Ketoprofen || diphenylacetic acid || Salicylic Acid || Phenylpropionates || Diphenylacetic Acids || Cinnamates || Fenoprofen || 3-phenylpropionic acid || hydratropic acid || mono-(2-ethylhexyl)phthalate || Vanillic Acid || Aminobenzoates || biphenylylacetic acid || Cyclohexanecarboxylic Acids || cinnamic acid || Indoprofen || methyl salicylate || Hydroxybenzoate Ethers || Diflunisal || Phenylacetates |
| Heat shock protein 90, HSP90, N-terminal domain | 0.2619 | INHERITED FROM: Cinnamates |
| DnaJ/Hsp40 cysteine-rich domain | 0.2619 | INHERITED FROM: Diclofenac || Phenylacetates |
| HSP90 C-terminal domain | 0.2619 | INHERITED FROM: Cinnamates |
| Hsp90 middle domain | 0.2619 | INHERITED FROM: Cinnamates |
| Sir2 family of transcriptional regulators | 0.3022 | INHERITED FROM: diisononyl phthalate |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.3022 | INHERITED FROM: Caffeic Acids || Eugenol || isoeugenol |
| Annexin | 0.3145 | INHERITED FROM: Ibuprofen || Phenylpropionates |
| Interleukin 8-like chemokines | 0.3661 | INHERITED FROM: Hydroxybenzoates || Cinnamates || Hydrolyzable Tannins || sirtinol || roflumilast N-oxide || Puromycin || Roflumilast || Imatinib Mesylate |
| FAD/NAD-linked reductases, N-terminal and central domains | 0.3865 | INHERITED FROM: Caffeic Acids || Eugenol || isoeugenol |
| ABC transporter ATPase domain-like | 0.3888 | INHERITED FROM: Hippurates || Bezafibrate |
| HSP40/DnaJ peptide-binding domain | 0.3948 | INHERITED FROM: Diclofenac || Phenylacetates |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0.3973 | INHERITED FROM: Salicylates || Aspirin |
| NADPH-cytochrome p450 reductase-like | 0.3973 | INHERITED FROM: Salicylates || Aspirin |
| MMP N-terminal domain | 0.4309 | INHERITED FROM: 3-caffeoyl-4-dihydrocaffeoylquinic acid || Chlorogenic Acid || Cyclohexanecarboxylic Acids |
| Caspase recruitment domain, CARD | 0.4309 | INHERITED FROM: propylparaben || Parabens |
| Cytochrome p450 reductase N-terminal domain-like | 0.4433 | INHERITED FROM: Aspirin |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0.4481 | INHERITED FROM: caffeic acid phenethyl ester |
| Tubulin, C-terminal domain | 0.4538 | INHERITED FROM: Diclofenac |
| Chaperone J-domain | 0.4809 | INHERITED FROM: Diclofenac || Phenylacetates |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0.49 | INHERITED FROM: Diclofenac |
| Hemopexin-like domain | 0.5229 | INHERITED FROM: 3-caffeoyl-4-dihydrocaffeoylquinic acid || Chlorogenic Acid |
| Voltage-gated potassium channels | 0.5335 | INHERITED FROM: Flufenamic Acid || ortho-Aminobenzoates || Fenamates || Niflumic Acid |
| Matrix metalloproteases, catalytic domain | 0.6148 | INHERITED FROM: 3-caffeoyl-4-dihydrocaffeoylquinic acid || Chlorogenic Acid |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0.6558 | INHERITED FROM: 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid |
| Tyrosine-dependent oxidoreductases | 0.6609 | INHERITED FROM: DEET |
| TNF-like | 0.7111 | INHERITED FROM: Bezafibrate |
| ValRS/IleRS/LeuRS editing domain | 0.7144 | INHERITED FROM: Ibuprofen || Phenylpropionates |
| PAZ domain | 0.7584 | INHERITED FROM: Diclofenac |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.819 | INHERITED FROM: Ibuprofen || Phenylpropionates |
| Interleukin-1 (IL-1) | 0.8747 | INHERITED FROM: Ibuprofen || ortho-Aminobenzoates || Phenylpropionates || Caffeic Acids || Eugenol || Aminobenzoates || Salicylates || Aspirin |
| Gonadodropin/Follitropin | 0.8904 | INHERITED FROM: mono-(2-ethylhexyl)phthalate |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.8904 | INHERITED FROM: Ibuprofen || Phenylpropionates |
| Motor proteins | 0.8977 | INHERITED FROM: 4-methoxycinnamate methyl ester |
| Homeodomain | 0.8999 | INHERITED FROM: Chloromercuribenzoates || Mercuribenzoates |
| Actin/HSP70 | 0.9182 | INHERITED FROM: Phenylbutyrates || aurin || 4-phenylbutyric acid || Cyclohexanecarboxylic Acids |
| Group II chaperonin (CCT, TRIC), apical domain | 0.9675 | INHERITED FROM: 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid |
| Nicotinic receptor ligand binding domain-like | 0.976 | INHERITED FROM: benzamide || 4-chloro-N-(2-(2-thienyl)imidazo(1,2-a)pyridin-3-yl)benzamide |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.997 | INHERITED FROM: benzamide || 4-chloro-N-(2-(2-thienyl)imidazo(1,2-a)pyridin-3-yl)benzamide |
| Intermediate filament protein, coiled coil region | 0.9997 | INHERITED FROM: ethyl-p-((E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-1-propenyl)benzoic acid |
| Group II chaperonin (CCT, TRIC), ATPase domain | 1 | INHERITED FROM: 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid |
| Rhodopsin-like | 1 | INHERITED FROM: 5-(3-(3-hydroxyphenoxy)azetidin-1-yl)-5-methyl-2,2-diphenylhexanamide || Benzilates || 1-(8-bromobenzo(1,2-b;4,5-b')difuran-4-yl)-2-aminopropane || (N-N'-bis-(2-(1H-indol-3-yl)-ethyl)-N,N'-bis-(3-thiomorpholin-4-yl-propyl)-phthalamide) || Quinuclidinyl Benzilate |
| Classic zinc finger, C2H2 | 1 | INHERITED FROM: pomalidomide |
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| Connexin43 | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | Direct |
| C5 cytosine-specific DNA methylase, DCM | 0 | Direct |
| p53 tetramerization domain | 0 | Direct |
| Proton glutamate symport protein | 0 | Direct |
| Alkaline phosphatase | 0 | Direct |
| A20-like zinc finger | 0 | Direct |
| IP3 receptor type 1 binding core, domain 2 | 0 | Direct |
| 2'-5'-oligoadenylate synthetase 1, OAS1, second domain | 0 | Direct |
| Serine carboxypeptidase-like | 0 | Direct |
| Assembly domain of cartilage oligomeric matrix protein | 0 | Direct |
| MOSC N-terminal domain-like | 0 | Direct |
| Phosphoglucomutase, C-terminal domain | 0 | Direct |
| DEATH effector domain, DED | 0 | Direct |
| MAPEG domain | 0 | Direct |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain | 0 | Direct |
| PAS domain of steroid receptor coactivator 1A, NCo-A1 | 0 | Direct |
| P-domain of calnexin/calreticulin | 0 | Direct |
| E2F dimerization segment | 0 | Direct |
| 2'-5'-oligoadenylate synthetase 1, OAS1, N-terminal domain | 0 | Direct |
| Platelet-derived growth factor-like | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| Fibrinogen coiled-coil and central regions | 0 | Direct |
| Tetrahydrofolate dehydrogenase/cyclohydrolase | 0 | Direct |
| Alpha-adaptin ear subdomain-like | 0 | Direct |
| Prohormone convertase 1 pro-domain | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, C-terminal domain | 0 | Direct |
| Small-conductance potassium channel | 0 | Direct |
| Integrin beta tail domain | 0 | Direct |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain | 0 | Direct |
| p53 DNA-binding domain-like | 0 | Direct |
| Cysteine rich domain | 0 | Direct |
| RILP dimerisation region | 0 | Direct |
| Transferrin | 0 | Direct |
| IMD domain | 0 | Direct |
| CAT-like | 0 | Direct |
| Adenylyltransferase | 0 | Direct |
| Phoshatidylinositol transfer protein, PITP | 0 | Direct |
| PUA domain | 0 | Direct |
| LCCL domain | 0 | Direct |
| Retinoblastoma tumor suppressor domains | 0 | Direct |
| Serum paraoxonase/arylesterase 1, PON1 | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Oligosaccharide phosphorylase | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| Hexokinase | 0 | Direct |
| Calnexin/calreticulin | 0 | Direct |
| Aminoacid dehydrogenase-like, C-terminal domain | 0 | Direct |
| N-terminal domain of cbl (N-cbl) | 0 | Direct |
| TB module/8-cys domain | 0 | Direct |
| BSD domain | 0 | Direct |
| TSP type-3 repeat | 0 | Direct |
| Tissue inhibitor of metalloproteinases, TIMP | 0 | Direct |
| Integrin beta EGF-like domains | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| Clathrin adaptor appendage, alpha and beta chain-specific domain | 0 | Direct |
| Malic enzyme N-domain | 0 | Direct |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | Direct |
| SMAD domain | 0 | Direct |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
| Phosphoglucomutase, first 3 domains | 0 | Direct |
| HCDH C-domain-like | 0 | Direct |
| Thrombospondin C-terminal domain | 0 | Direct |
| Cytochrome P450 | 0.00001401 | Direct |
| DEATH domain, DD | 0.0000388 | Direct |
| Leucine zipper domain | 0.00006404 | Direct |
| Fibronectin type III | 0.0001302 | Direct |
| Growth factor receptor domain | 0.0001599 | Direct |
| Laminin G-like module | 0.0001626 | Direct |
| Protein kinases, catalytic subunit | 0.0001631 | Direct |
| Nuclear receptor ligand-binding domain | 0.0001927 | Direct |
| Integrin domains | 0.0001944 | Direct |
| A DNA-binding domain in eukaryotic transcription factors | 0.0002333 | Direct |
| Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain) | 0.0003831 | Direct |
| Nuclear receptor | 0.0003956 | Direct |
| EGF-type module | 0.001401 | Inherited |
| SH2 domain | 0.001403 | Inherited |
| Metallothionein | 0.002487 | Inherited |
| PDEase | 0.007754 | Inherited |
| PAPS sulfotransferase | 0.008377 | Inherited |
| C1 set domains (antibody constant domain-like) | 0.008849 | Inherited |
| Thyroglobulin type-1 domain | 0.009426 | Inherited |
| Frizzled cysteine-rich domain | 0.01194 | Inherited |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.02367 | Inherited |
| Glutathione S-transferase (GST), C-terminal domain | 0.02527 | Inherited |
| Ephrin receptor ligand binding domain | 0.03008 | Inherited |
| MHC antigen-recognition domain | 0.03436 | Inherited |
| Cell cycle transcription factor e2f-dp | 0.03447 | Inherited |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.0362 | Inherited |
| Caspase catalytic domain | 0.05872 | Inherited |
| Short-chain cytokines | 0.06182 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.06923 | Inherited |
| Hypoxia-inducible factor Hif2a, C-terminal domain | 0.07975 | Inherited |
| Proprotein convertase P-domain | 0.0822 | Inherited |
| STAT | 0.0822 | Inherited |
| 14-3-3 protein | 0.0822 | Inherited |
| Transcription factor STAT-4 N-domain | 0.0822 | Inherited |
| STAT DNA-binding domain | 0.0822 | Inherited |
| Fibronectin type II module | 0.08635 | Inherited |
| TBP-associated factors, TAFs | 0.09251 | Inherited |
| ets domain | 0.09681 | Inherited |
| Glutathione S-transferase (GST), N-terminal domain | 0.1012 | Inherited |
| TNF receptor-like | 0.1012 | Inherited |
| Canonical RBD | 0.1027 | Inherited |
| I set domains | 0.108 | Inherited |
| Aldo-keto reductases (NADP) | 0.1091 | Inherited |
| Bcl-2 inhibitors of programmed cell death | 0.1181 | Inherited |
| Rel/Dorsal transcription factors, DNA-binding domain | 0.1213 | Inherited |
| Histone deacetylase, HDAC | 0.1251 | Inherited |
| Acetylcholinesterase-like | 0.1434 | Inherited |
| Long-chain cytokines | 0.1434 | Inherited |
| Pentraxin (pentaxin) | 0.1773 | Inherited |
| Kinase associated domain 1, KA1 | 0.1796 | Inherited |
| a tRNA synthase domain | 0.1796 | Inherited |
| DNA polymerase I | 0.1873 | Inherited |
| Fatty acid binding protein-like | 0.1997 | Inherited |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.1997 | Inherited |
| Cyclin | 0.2066 | Inherited |
| ABC transporter transmembrane region | 0.2078 | Inherited |
| Inhibitor of apoptosis (IAP) repeat | 0.226 | Inherited |
| S100 proteins | 0.2278 | Inherited |
| Higher-molecular-weight phosphotyrosine protein phosphatases | 0.2327 | Inherited |
| Complement components | 0.2469 | Inherited |
| C2 set domains | 0.2469 | Inherited |
| Alpha-macroglobulin receptor domain | 0.2469 | Inherited |
| YWTD domain | 0.2531 | Inherited |
| UDPGT-like | 0.2543 | Inherited |
| Heat shock protein 90, HSP90, N-terminal domain | 0.2619 | Inherited |
| DnaJ/Hsp40 cysteine-rich domain | 0.2619 | Inherited |
| HSP90 C-terminal domain | 0.2619 | Inherited |
| Hsp90 middle domain | 0.2619 | Inherited |
| Sir2 family of transcriptional regulators | 0.3022 | Inherited |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.3022 | Inherited |
| Annexin | 0.3145 | Inherited |
| Interleukin 8-like chemokines | 0.3661 | Inherited |
| FAD/NAD-linked reductases, N-terminal and central domains | 0.3865 | Inherited |
| ABC transporter ATPase domain-like | 0.3888 | Inherited |
| HSP40/DnaJ peptide-binding domain | 0.3948 | Inherited |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0.3973 | Inherited |
| NADPH-cytochrome p450 reductase-like | 0.3973 | Inherited |
| MMP N-terminal domain | 0.4309 | Inherited |
| Caspase recruitment domain, CARD | 0.4309 | Inherited |
| Cytochrome p450 reductase N-terminal domain-like | 0.4433 | Inherited |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0.4481 | Inherited |
| Tubulin, C-terminal domain | 0.4538 | Inherited |
| Chaperone J-domain | 0.4809 | Inherited |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0.49 | Inherited |
| Hemopexin-like domain | 0.5229 | Inherited |
| Voltage-gated potassium channels | 0.5335 | Inherited |
| Matrix metalloproteases, catalytic domain | 0.6148 | Inherited |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0.6558 | Inherited |
| Tyrosine-dependent oxidoreductases | 0.6609 | Inherited |
| TNF-like | 0.7111 | Inherited |
| ValRS/IleRS/LeuRS editing domain | 0.7144 | Inherited |
| PAZ domain | 0.7584 | Inherited |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0.819 | Inherited |
| Interleukin-1 (IL-1) | 0.8747 | Inherited |
| Gonadodropin/Follitropin | 0.8904 | Inherited |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.8904 | Inherited |
| Motor proteins | 0.8977 | Inherited |
| Homeodomain | 0.8999 | Inherited |
| Actin/HSP70 | 0.9182 | Inherited |
| Group II chaperonin (CCT, TRIC), apical domain | 0.9675 | Inherited |
| Nicotinic receptor ligand binding domain-like | 0.976 | Inherited |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.997 | Inherited |
| Intermediate filament protein, coiled coil region | 0.9997 | Inherited |
| Group II chaperonin (CCT, TRIC), ATPase domain | 1 | Inherited |
| Rhodopsin-like | 1 | Inherited |
| Classic zinc finger, C2H2 | 1 | Inherited |
LINKTO: Domain2BO Download and Domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Single)( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| beta-lactamase/transpeptidase-like | 0 | DIRECT |
| N-terminal domain of cbl (N-cbl) | 0 | DIRECT |
| RILP dimerisation region | 0 | DIRECT |
| Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | DIRECT |
| Fibrinogen coiled-coil and central regions | 0 | DIRECT |
| P-domain of calnexin/calreticulin | 0 | DIRECT |
| LCCL domain | 0 | DIRECT |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
| Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
| MAPEG domain-like | 0 | DIRECT |
| Di-copper centre-containing domain | 0 | DIRECT |
| TB module/8-cys domain | 0 | DIRECT |
| Integrin beta tail domain | 0 | DIRECT |
| FAD-linked oxidases, C-terminal domain | 0 | DIRECT |
| BSD domain-like | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| Assembly domain of cartilage oligomeric matrix protein | 0 | DIRECT |
| Connexin43 | 0 | DIRECT |
| Nicotinate/Quinolinate PRTase C-terminal domain-like | 0 | DIRECT |
| Small-conductance potassium channel | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| Phosphoglucomutase, first 3 domains | 0 | DIRECT |
| AhpD-like | 0 | DIRECT |
| TSP type-3 repeat | 0 | DIRECT |
| Proton glutamate symport protein | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| MOSC N-terminal domain-like | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| N-(deoxy)ribosyltransferase-like | 0 | DIRECT |
| Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | DIRECT |
| Growth factor receptor domain | 0.000000477 | DIRECT |
| EGF/Laminin | 0.000002751 | DIRECT |
| Cytochrome P450 | 0.000003574 | DIRECT |
| Protein kinase-like (PK-like) | 0.000007716 | DIRECT |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.00001658 | DIRECT |
| Leucine zipper domain | 0.00002697 | DIRECT |
| Fibronectin type III | 0.0000342 | DIRECT |
| Nuclear receptor ligand-binding domain | 0.00008731 | DIRECT |
| Integrin domains | 0.0001017 | DIRECT |
| A DNA-binding domain in eukaryotic transcription factors | 0.0001328 | DIRECT |
| SH2 domain | 0.0005714 | DIRECT |
| Metallothionein | 0.001618 | INHERITED FROM: Chloromercuribenzoates || Chlorobenzoates || Mercuribenzoates |
| Kringle-like | 0.00214 | INHERITED FROM: Hydroxybenzoates || Aspirin |
| TSP-1 type 1 repeat | 0.00482 | INHERITED FROM: Benzamides || Chloromercuribenzoates |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.005449 | INHERITED FROM: butylidenephthalide || Phthalic Anhydrides |
| Thyroglobulin type-1 domain | 0.006344 | INHERITED FROM: Chloromercuribenzoates |
| PYP-like sensor domain (PAS domain) | 0.007593 | INHERITED FROM: Benzocaine || Hydroxybenzoates || Benzoates || Aminobenzoates || butylbenzyl phthalate || butamben |
| Frizzled cysteine-rich domain | 0.00796 | INHERITED FROM: Diclofenac |
| Calcium-dependent phosphotriesterase | 0.009839 | INHERITED FROM: phenylacetic acid |
| E2F-DP heterodimerization region | 0.009839 | INHERITED FROM: Diclofenac || Caffeic Acids || Phenylacetates || Cinnamates || UF010 compound || Eugenol |
| HD-domain/PDEase-like | 0.01389 | INHERITED FROM: Cilomilast || Benzamides || Roflumilast || Cyclohexanecarboxylic Acids |
| p53-like transcription factors | 0.01478 | INHERITED FROM: Diclofenac || Triiodobenzoic Acids || Phenylacetates || Iopamidol || Cinnamates || Iodobenzoates || Anacardic Acids || Salicylates || Imatinib Mesylate |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.01748 | INHERITED FROM: aurin || 4-phenylbutyric acid || Cyclohexanecarboxylic Acids || Chloromercuribenzoates || Phenylbutyrates |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.01748 | INHERITED FROM: aurin || 4-phenylbutyric acid || Cyclohexanecarboxylic Acids || Chloromercuribenzoates || Phenylbutyrates |
| Caspase-like | 0.01841 | INHERITED FROM: carboxycinnamic acid bishydroxamide || NCQ 344 || Remoxipride || Hydroxybenzoates || Niflumic Acid || dehydroxymethylepoxyquinomicin || Phthalimides || butylidenephthalide || Bromobenzoates || 4-phenylbutyric acid || Cyclohexanecarboxylic Acids || Fenamates || Phenylacetates || Phthalic Anhydrides || NCX 4040 || Aminobenzoates || propylparaben || Cinnamates || Parabens || Anacardic Acids || Imatinib Mesylate || mono-(2-ethylhexyl)phthalate || 3-bromoacetylamino benzoic acid ethyl ester || p-carboxymethylphenyl 1,1-bis(3'-indolyl)-1-(p-carboxymethylphenyl)methane || Phenylbutyrates || Eugenol |
| MHC antigen-recognition domain | 0.02283 | INHERITED FROM: lumiracoxib || tamibarotene || entinostat |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0.03807 | INHERITED FROM: tamibarotene || VER-246608 |
| HLH, helix-loop-helix DNA-binding domain | 0.04124 | INHERITED FROM: Benzocaine || 3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid || butylbenzyl phthalate || butamben || Chlorobenzoates |
| Zn-binding ribosomal proteins | 0.04164 | INHERITED FROM: 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Cinnamates |
| Metalloproteases ("zincins"), catalytic domain | 0.04398 | INHERITED FROM: 3-caffeoyl-4-dihydrocaffeoylquinic acid || PD 0325901 |
| FnI-like domain | 0.04728 | INHERITED FROM: Benzamides |
| TNF receptor-like | 0.05836 | INHERITED FROM: 4-(3-(1-adamantyl)-4-hydroxyphenyl)-3-chlorocinnamic acid || Hydroxybenzoates || Aspirin || Ibuprofen || Phenylpropionates || Parabens |
| 14-3-3 protein | 0.06599 | INHERITED FROM: Diclofenac || Aspirin || Salicylates |
| STAT | 0.06599 | INHERITED FROM: Diclofenac || Aspirin || Phenylacetates || Cinnamates || Salicylates || Eugenol |
| KA1-like | 0.06599 | INHERITED FROM: Dibutyl Phthalate |
| Transcription factor STAT-4 N-domain | 0.06599 | INHERITED FROM: Diclofenac || Aspirin || Phenylacetates || Cinnamates || Salicylates || Eugenol |
| DEATH domain | 0.06708 | INHERITED FROM: carboxycinnamic acid bishydroxamide || Diclofenac || 4-(3-(1-adamantyl)-4-hydroxyphenyl)-3-chlorocinnamic acid || Hydroxybenzoates || dehydroxymethylepoxyquinomicin || Phthalimides || propylparaben || Cinnamates || Parabens || Anacardic Acids || Imatinib Mesylate || caffeic acid phenethyl ester |
| HMG-box | 0.06744 | INHERITED FROM: methylparaben |
| Kazal-type serine protease inhibitors | 0.0688 | INHERITED FROM: Benzilates || trospium chloride || Diphenylacetic Acids |
| Immunoglobulin | 0.07357 | INHERITED FROM: HX 630 || lumiracoxib || Lenalidomide |
| NAD(P)-linked oxidoreductase | 0.08474 | INHERITED FROM: Hydroxybenzoates || methyl salicylate || Caffeic Acids || 3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid || Flufenamic Acid || Meclofenamic Acid || Benzoic Acid || Ibuprofen || Fenamates || Phenylpropionates || fenamic acid || Aminobenzoates || 4-hydroxybenzoic acid || isoeugenol || Cinnamates || octyl gallate || caffeic acid phenethyl ester |
| GST C-terminal domain-like | 0.08593 | INHERITED FROM: Diclofenac || apple polyphenol extract || methyleugenol || 4-phenylbutyric acid || Fenamates || Aminobenzoates || ortho-Aminobenzoates || Eugenol |
| EF-hand | 0.09086 | INHERITED FROM: entinostat |
| Bcl-2 inhibitors of programmed cell death | 0.09319 | INHERITED FROM: carboxycinnamic acid bishydroxamide || BP-1-102 || Hydrolyzable Tannins || Puromycin || Hydroxybenzoates || Triiodobenzoic Acids || Phthalimides || Aspirin || atranorin || Fenamates || Phenylacetates || Aminobenzoates || propylparaben || methyl caffeate || Cinnamates || Parabens || Iodobenzoates || gyrophoric acid || Imatinib Mesylate || ortho-Aminobenzoates |
| Arginase/deacetylase | 0.1151 | INHERITED FROM: mocetinostat |
| MFS general substrate transporter | 0.1254 | INHERITED FROM: Benzilates || Ketoprofen || Sulpiride || trospium chloride || Aminohippuric Acids || Salicylic Acid || p-Aminohippuric Acid || Hippurates || Fenamates || Bumetanide || Phenylpropionates || Diphenylacetic Acids || Aminobenzoates || 5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methylbenzoic acid |
| NAD(P)-binding Rossmann-fold domains | 0.144 | INHERITED FROM: methyl salicylate || Fenoprofen || DEET |
| Nucleic acid-binding proteins | 0.1595 | INHERITED FROM: 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Quinic Acid |
| DNA/RNA polymerases | 0.1625 | INHERITED FROM: Diclofenac |
| Cysteine-rich domain | 0.1672 | INHERITED FROM: Diclofenac |
| Cyclin-like | 0.1762 | INHERITED FROM: Diclofenac || 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid || Hydroxybenzoates || butylidenephthalide || Ro 41-5253 || Parabens || UF010 compound |
| Inhibitor of apoptosis (IAP) repeat | 0.19 | INHERITED FROM: Hydroxybenzoates || dehydroxymethylepoxyquinomicin || Caffeic Acids || Anacardic Acids || caffeic acid phenethyl ester |
| Alpha-macroglobulin receptor domain | 0.2079 | INHERITED FROM: Phthalic Acids |
| YWTD domain | 0.2096 | INHERITED FROM: Ibuprofen || Phenylpropionates |
| (Phosphotyrosine protein) phosphatases II | 0.22 | INHERITED FROM: anthranilic acid || Aminobenzoates || 2-(oxalylamino)benzoic acid || ortho-Aminobenzoates |
| DnaJ/Hsp40 cysteine-rich domain | 0.226 | INHERITED FROM: Diclofenac || Phenylacetates |
| HSP90 C-terminal domain | 0.226 | INHERITED FROM: Cinnamates |
| RNA-binding domain, RBD | 0.2298 | INHERITED FROM: butylidenephthalide |
| "Winged helix" DNA-binding domain | 0.2374 | INHERITED FROM: UF010 compound |
| Thioredoxin-like | 0.2381 | INHERITED FROM: apple polyphenol extract || o-Phthalaldehyde || methyleugenol || Fenamates || Quinic Acid || ortho-Aminobenzoates |
| ABC transporter transmembrane region | 0.2391 | INHERITED FROM: Bezafibrate || Imatinib Mesylate |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.2601 | INHERITED FROM: Caffeic Acids || isoeugenol || Cinnamates || Eugenol |
| PAP/OAS1 substrate-binding domain | 0.2667 | INHERITED FROM: tamibarotene |
| Annexin | 0.2667 | INHERITED FROM: Diethylhexyl Phthalate || Ibuprofen || Phenylpropionates |
| FAD/NAD(P)-binding domain | 0.2854 | INHERITED FROM: isoeugenol || Nitrobenzoates |
| Interleukin 8-like chemokines | 0.298 | INHERITED FROM: Hydrolyzable Tannins || Puromycin || Hydroxybenzoates || Roflumilast || roflumilast N-oxide || Phenylpropionates || Cinnamates || Imatinib Mesylate || sirtinol |
| HSP40/DnaJ peptide-binding domain | 0.3432 | INHERITED FROM: Diclofenac || Phenylacetates |
| Flavoproteins | 0.3432 | INHERITED FROM: Hydroxybenzoates || Aspirin || Benzoic Acid || Fenamates || Aminobenzoates || Salicylates || ortho-Aminobenzoates |
| Sm-like ribonucleoproteins | 0.3529 | INHERITED FROM: 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid |
| PGBD-like | 0.3702 | INHERITED FROM: 3-caffeoyl-4-dihydrocaffeoylquinic acid || Cyclohexanecarboxylic Acids || Ibuprofen || Chlorogenic Acid |
| Voltage-gated potassium channels | 0.3851 | INHERITED FROM: Niflumic Acid || Flufenamic Acid |
| Tubulin C-terminal domain-like | 0.388 | INHERITED FROM: Diclofenac || Phenylacetates |
| Chaperone J-domain | 0.3987 | INHERITED FROM: Diclofenac || Phenylacetates |
| FYVE/PHD zinc finger | 0.4084 | INHERITED FROM: 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide |
| Cytokine | 0.451 | INHERITED FROM: ortho-Aminobenzoates |
| Hemopexin-like domain | 0.4557 | INHERITED FROM: 3-caffeoyl-4-dihydrocaffeoylquinic acid || Chlorogenic Acid |
| Tubulin nucleotide-binding domain-like | 0.4708 | INHERITED FROM: Diclofenac || Phenylacetates |
| Cystine-knot cytokines | 0.4713 | INHERITED FROM: Procarbazine || Dibutyl Phthalate || MOPP protocol |
| Homeodomain-like | 0.4792 | INHERITED FROM: Chloromercuribenzoates || Mercuribenzoates |
| S15/NS1 RNA-binding domain | 0.5387 | INHERITED FROM: C646 compound |
| UDP-Glycosyltransferase/glycogen phosphorylase | 0.5768 | INHERITED FROM: Diclofenac || diphenylacetic acid || Ketoprofen || Coumaric Acids || Diflunisal || Salicylic Acid || ferulic acid || methyl salicylate || Vanillic Acid || Cyclohexanecarboxylic Acids || Fenamates || Phenylacetates || Phenylpropionates || Diphenylacetic Acids || Aminobenzoates || Fenoprofen || Cinnamates || biphenylylacetic acid || cinnamic acid || Hydroxybenzoate Ethers || hydratropic acid || mono-(2-ethylhexyl)phthalate || 3-phenylpropionic acid || Indoprofen || ortho-Aminobenzoates |
| SMAD/FHA domain | 0.6184 | INHERITED FROM: sirtinol |
| TNF-like | 0.6274 | INHERITED FROM: Bezafibrate |
| Actin-like ATPase domain | 0.6449 | INHERITED FROM: aurin || 4-phenylbutyric acid || Phenylbutyrates |
| ValRS/IleRS/LeuRS editing domain | 0.6568 | INHERITED FROM: Ibuprofen || Phenylpropionates |
| 4-helical cytokines | 0.6788 | INHERITED FROM: Cilomilast || Sodium Salicylate || Hydroxybenzoates || Phthalimides || Cyclohexanecarboxylic Acids || 4'-hydroxydiclofenac || Phenylacetates || Ro 41-5253 || Phthalic Anhydrides || Aminobenzoates || FK 706 |
| Nucleotidylyl transferase | 0.7189 | INHERITED FROM: Ibuprofen || Phenylpropionates |
| DHS-like NAD/FAD-binding domain | 0.756 | INHERITED FROM: diisononyl phthalate |
| Translation proteins SH3-like domain | 0.7697 | INHERITED FROM: 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid |
| GroEL-intermediate domain like | 0.7732 | INHERITED FROM: 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid |
| PAZ domain | 0.8171 | INHERITED FROM: Diclofenac || Phenylacetates |
| Lipocalins | 0.8268 | INHERITED FROM: Bezafibrate |
| Prefoldin | 0.8406 | INHERITED FROM: ethyl-p-((E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-1-propenyl)benzoic acid |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.9053 | INHERITED FROM: Ibuprofen || Phenylpropionates |
| GroEL apical domain-like | 0.9059 | INHERITED FROM: 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid |
| GroEL equatorial domain-like | 0.9059 | INHERITED FROM: 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid |
| Translation proteins | 0.9096 | INHERITED FROM: butylidenephthalide || Phthalic Anhydrides |
| Intermediate filament protein, coiled coil region | 0.9392 | INHERITED FROM: ethyl-p-((E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-1-propenyl)benzoic acid |
| Nicotinic receptor ligand binding domain-like | 0.9405 | INHERITED FROM: 4-chloro-N-(2-(2-thienyl)imidazo(1,2-a)pyridin-3-yl)benzamide || benzamide |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.9405 | INHERITED FROM: 4-chloro-N-(2-(2-thienyl)imidazo(1,2-a)pyridin-3-yl)benzamide || benzamide |
| Ribosomal protein S5 domain 2-like | 0.9744 | INHERITED FROM: tamibarotene |
| Quinoprotein alcohol dehydrogenase-like | 0.9882 | INHERITED FROM: 4-phenylbutyric acid || Phenylbutyrates |
| Mitochondrial carrier | 0.999 | INHERITED FROM: 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid |
| Family A G protein-coupled receptor-like | 1 | INHERITED FROM: Benzilates || Quinuclidinyl Benzilate || 1-(8-bromobenzo(1,2-b;4,5-b')difuran-4-yl)-2-aminopropane || (N-N'-bis-(2-(1H-indol-3-yl)-ethyl)-N,N'-bis-(3-thiomorpholin-4-yl-propyl)-phthalamide) || 5-(3-(3-hydroxyphenoxy)azetidin-1-yl)-5-methyl-2,2-diphenylhexanamide |
| beta-beta-alpha zinc fingers | 1 | INHERITED FROM: pomalidomide |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| beta-lactamase/transpeptidase-like | 0 | Direct |
| N-terminal domain of cbl (N-cbl) | 0 | Direct |
| RILP dimerisation region | 0 | Direct |
| Cation efflux protein cytoplasmic domain-like | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | Direct |
| Fibrinogen coiled-coil and central regions | 0 | Direct |
| P-domain of calnexin/calreticulin | 0 | Direct |
| LCCL domain | 0 | Direct |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
| Phosphoglucomutase, C-terminal domain | 0 | Direct |
| MAPEG domain-like | 0 | Direct |
| Di-copper centre-containing domain | 0 | Direct |
| TB module/8-cys domain | 0 | Direct |
| Integrin beta tail domain | 0 | Direct |
| FAD-linked oxidases, C-terminal domain | 0 | Direct |
| BSD domain-like | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| Assembly domain of cartilage oligomeric matrix protein | 0 | Direct |
| Connexin43 | 0 | Direct |
| Nicotinate/Quinolinate PRTase C-terminal domain-like | 0 | Direct |
| Small-conductance potassium channel | 0 | Direct |
| p53 tetramerization domain | 0 | Direct |
| Phosphoglucomutase, first 3 domains | 0 | Direct |
| AhpD-like | 0 | Direct |
| TSP type-3 repeat | 0 | Direct |
| Proton glutamate symport protein | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
| MOSC N-terminal domain-like | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| N-(deoxy)ribosyltransferase-like | 0 | Direct |
| Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | Direct |
| Growth factor receptor domain | 0.000000477 | Direct |
| EGF/Laminin | 0.000002751 | Direct |
| Cytochrome P450 | 0.000003574 | Direct |
| Protein kinase-like (PK-like) | 0.000007716 | Direct |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.00001658 | Direct |
| Leucine zipper domain | 0.00002697 | Direct |
| Fibronectin type III | 0.0000342 | Direct |
| Nuclear receptor ligand-binding domain | 0.00008731 | Direct |
| Integrin domains | 0.0001017 | Direct |
| A DNA-binding domain in eukaryotic transcription factors | 0.0001328 | Direct |
| SH2 domain | 0.0005714 | Direct |
| Metallothionein | 0.001618 | Inherited |
| Kringle-like | 0.00214 | Inherited |
| TSP-1 type 1 repeat | 0.00482 | Inherited |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.005449 | Inherited |
| Thyroglobulin type-1 domain | 0.006344 | Inherited |
| PYP-like sensor domain (PAS domain) | 0.007593 | Inherited |
| Frizzled cysteine-rich domain | 0.00796 | Inherited |
| Calcium-dependent phosphotriesterase | 0.009839 | Inherited |
| E2F-DP heterodimerization region | 0.009839 | Inherited |
| HD-domain/PDEase-like | 0.01389 | Inherited |
| p53-like transcription factors | 0.01478 | Inherited |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.01748 | Inherited |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.01748 | Inherited |
| Caspase-like | 0.01841 | Inherited |
| MHC antigen-recognition domain | 0.02283 | Inherited |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0.03807 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.04124 | Inherited |
| Zn-binding ribosomal proteins | 0.04164 | Inherited |
| Metalloproteases ("zincins"), catalytic domain | 0.04398 | Inherited |
| FnI-like domain | 0.04728 | Inherited |
| TNF receptor-like | 0.05836 | Inherited |
| 14-3-3 protein | 0.06599 | Inherited |
| STAT | 0.06599 | Inherited |
| KA1-like | 0.06599 | Inherited |
| Transcription factor STAT-4 N-domain | 0.06599 | Inherited |
| DEATH domain | 0.06708 | Inherited |
| HMG-box | 0.06744 | Inherited |
| Kazal-type serine protease inhibitors | 0.0688 | Inherited |
| Immunoglobulin | 0.07357 | Inherited |
| NAD(P)-linked oxidoreductase | 0.08474 | Inherited |
| GST C-terminal domain-like | 0.08593 | Inherited |
| EF-hand | 0.09086 | Inherited |
| Bcl-2 inhibitors of programmed cell death | 0.09319 | Inherited |
| Arginase/deacetylase | 0.1151 | Inherited |
| MFS general substrate transporter | 0.1254 | Inherited |
| NAD(P)-binding Rossmann-fold domains | 0.144 | Inherited |
| Nucleic acid-binding proteins | 0.1595 | Inherited |
| DNA/RNA polymerases | 0.1625 | Inherited |
| Cysteine-rich domain | 0.1672 | Inherited |
| Cyclin-like | 0.1762 | Inherited |
| Inhibitor of apoptosis (IAP) repeat | 0.19 | Inherited |
| Alpha-macroglobulin receptor domain | 0.2079 | Inherited |
| YWTD domain | 0.2096 | Inherited |
| (Phosphotyrosine protein) phosphatases II | 0.22 | Inherited |
| DnaJ/Hsp40 cysteine-rich domain | 0.226 | Inherited |
| HSP90 C-terminal domain | 0.226 | Inherited |
| RNA-binding domain, RBD | 0.2298 | Inherited |
| "Winged helix" DNA-binding domain | 0.2374 | Inherited |
| Thioredoxin-like | 0.2381 | Inherited |
| ABC transporter transmembrane region | 0.2391 | Inherited |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.2601 | Inherited |
| PAP/OAS1 substrate-binding domain | 0.2667 | Inherited |
| Annexin | 0.2667 | Inherited |
| FAD/NAD(P)-binding domain | 0.2854 | Inherited |
| Interleukin 8-like chemokines | 0.298 | Inherited |
| HSP40/DnaJ peptide-binding domain | 0.3432 | Inherited |
| Flavoproteins | 0.3432 | Inherited |
| Sm-like ribonucleoproteins | 0.3529 | Inherited |
| PGBD-like | 0.3702 | Inherited |
| Voltage-gated potassium channels | 0.3851 | Inherited |
| Tubulin C-terminal domain-like | 0.388 | Inherited |
| Chaperone J-domain | 0.3987 | Inherited |
| FYVE/PHD zinc finger | 0.4084 | Inherited |
| Cytokine | 0.451 | Inherited |
| Hemopexin-like domain | 0.4557 | Inherited |
| Tubulin nucleotide-binding domain-like | 0.4708 | Inherited |
| Cystine-knot cytokines | 0.4713 | Inherited |
| Homeodomain-like | 0.4792 | Inherited |
| S15/NS1 RNA-binding domain | 0.5387 | Inherited |
| UDP-Glycosyltransferase/glycogen phosphorylase | 0.5768 | Inherited |
| SMAD/FHA domain | 0.6184 | Inherited |
| TNF-like | 0.6274 | Inherited |
| Actin-like ATPase domain | 0.6449 | Inherited |
| ValRS/IleRS/LeuRS editing domain | 0.6568 | Inherited |
| 4-helical cytokines | 0.6788 | Inherited |
| Nucleotidylyl transferase | 0.7189 | Inherited |
| DHS-like NAD/FAD-binding domain | 0.756 | Inherited |
| Translation proteins SH3-like domain | 0.7697 | Inherited |
| GroEL-intermediate domain like | 0.7732 | Inherited |
| PAZ domain | 0.8171 | Inherited |
| Lipocalins | 0.8268 | Inherited |
| Prefoldin | 0.8406 | Inherited |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0.9053 | Inherited |
| GroEL apical domain-like | 0.9059 | Inherited |
| GroEL equatorial domain-like | 0.9059 | Inherited |
| Translation proteins | 0.9096 | Inherited |
| Intermediate filament protein, coiled coil region | 0.9392 | Inherited |
| Nicotinic receptor ligand binding domain-like | 0.9405 | Inherited |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.9405 | Inherited |
| Ribosomal protein S5 domain 2-like | 0.9744 | Inherited |
| Quinoprotein alcohol dehydrogenase-like | 0.9882 | Inherited |
| Mitochondrial carrier | 0.999 | Inherited |
| Family A G protein-coupled receptor-like | 1 | Inherited |
| beta-beta-alpha zinc fingers | 1 | Inherited |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Duplex) in N- to C-terminal order( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
103647,103647
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat | 0 | DIRECT |
69012,55874
69012 - alpha-ketoacid dehydrogenase kinase, N-terminal domain
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | DIRECT |
53738,55957
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | DIRECT |
53223,51735
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
48726,56112
48726 - Immunoglobulin
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
57184,57610
57184 - Growth factor receptor domain
57610 - Thyroglobulin type-1 domain | 0 | DIRECT |
51905,47576
51905 - FAD/NAD(P)-binding domain
47576 - Calponin-homology domain, CH-domain | 0 | DIRECT |
57440,56436
57440 - Kringle-like
56436 - C-type lectin-like | 0 | DIRECT |
-7,56112
-7 - CATH
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
47668,47473
47668 - N-terminal domain of cbl (N-cbl)
47473 - EF-hand | 0 | DIRECT |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
48350,50044
48350 - GTPase activation domain, GAP
50044 - SH3-domain | 0 | DIRECT |
49899,63887
49899 - Concanavalin A-like lectins/glucanases
63887 - P-domain of calnexin/calreticulin | 0 | DIRECT |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | DIRECT |
57196,57581
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0 | DIRECT |
50156,52540
50156 - PDZ domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0 | DIRECT |
46785,158702
46785 - "Winged helix" DNA-binding domain
158702 - Sec63 N-terminal domain-like | 0 | DIRECT |
117839,56399
117839 - WWE domain
56399 - ADP-ribosylation | 0 | DIRECT |
52980,47781
52980 - Restriction endonuclease-like
47781 - RuvA domain 2-like | 0 | DIRECT |
57581,57581
57581 - TB module/8-cys domain
57581 - TB module/8-cys domain | 0 | DIRECT |
100895,50494
100895 - Kazal-type serine protease inhibitors
50494 - Trypsin-like serine proteases | 0 | DIRECT |
54236,57889
54236 - Ubiquitin-like
57889 - Cysteine-rich domain | 0 | DIRECT |
57581,57196
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0 | DIRECT |
103647,49899
103647 - TSP type-3 repeat
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
81324,53850
81324 - Voltage-gated potassium channels
53850 - Periplasmic binding protein-like II | 0 | DIRECT |
49785,53187
49785 - Galactose-binding domain-like
53187 - Zn-dependent exopeptidases | 0 | DIRECT |
141673,50800
141673 - MOSC N-terminal domain-like
50800 - PK beta-barrel domain-like | 0 | DIRECT |
49417,47719
49417 - p53-like transcription factors
47719 - p53 tetramerization domain | 0 | DIRECT |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | DIRECT |
53300,49265
53300 - vWA-like
49265 - Fibronectin type III | 0 | DIRECT |
56176,55103
56176 - FAD-binding/transporter-associated domain-like
55103 - FAD-linked oxidases, C-terminal domain | 0 | DIRECT |
74924,74924
74924 - Cap-Gly domain
74924 - Cap-Gly domain | 0 | DIRECT |
53300,49899
53300 - vWA-like
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
57184,57581
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain | 0 | DIRECT |
57414,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like | 0 | DIRECT |
54826,51604
54826 - Enolase N-terminal domain-like
51604 - Enolase C-terminal domain-like | 0 | DIRECT |
47005,52777
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
52777 - CoA-dependent acyltransferases | 0 | DIRECT |
81324,81327
81324 - Voltage-gated potassium channels
81327 - Small-conductance potassium channel | 0 | DIRECT |
50729,46785
50729 - PH domain-like
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
53300,69179
53300 - vWA-like
69179 - Integrin domains | 0 | DIRECT |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
100934,100934
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
57581,57184
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain | 0 | DIRECT |
52540,53254
52540 - P-loop containing nucleoside triphosphate hydrolases
53254 - Phosphoglycerate mutase-like | 0 | DIRECT |
49562,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain | 0 | DIRECT |
51230,47005
51230 - Single hybrid motif
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | DIRECT |
161111,160240
161111 - Cation efflux protein transmembrane domain-like
160240 - Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
47473,57610
47473 - EF-hand
57610 - Thyroglobulin type-1 domain | 0 | DIRECT |
55550,57850
55550 - SH2 domain
57850 - RING/U-box | 0 | DIRECT |
53850,53850
53850 - Periplasmic binding protein-like II
53850 - Periplasmic binding protein-like II | 0 | DIRECT |
69572,69572
69572 - Activating enzymes of the ubiquitin-like proteins
69572 - Activating enzymes of the ubiquitin-like proteins | 0 | DIRECT |
49695,50370
49695 - gamma-Crystallin-like
50370 - Ricin B-like lectins | 0 | DIRECT |
50370,57440
50370 - Ricin B-like lectins
57440 - Kringle-like | 0 | DIRECT |
47473,55550
47473 - EF-hand
55550 - SH2 domain | 0 | DIRECT |
100920,100934
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
56436,57535
56436 - C-type lectin-like
57535 - Complement control module/SCR domain | 0 | DIRECT |
48726,82895
48726 - Immunoglobulin
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
57889,49562
57889 - Cysteine-rich domain
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
57196,69687
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0 | DIRECT |
52540,-7
52540 - P-loop containing nucleoside triphosphate hydrolases
-7 - CATH | 0 | DIRECT |
63501,50242
63501 - Frizzled cysteine-rich domain
50242 - TIMP-like | 0 | DIRECT |
100895,100895
100895 - Kazal-type serine protease inhibitors
100895 - Kazal-type serine protease inhibitors | 0 | DIRECT |
52540,51045
52540 - P-loop containing nucleoside triphosphate hydrolases
51045 - WW domain | 0 | DIRECT |
56112,56112
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.0001543 | DIRECT |
47454,57959
47454 - A DNA-binding domain in eukaryotic transcription factors
57959 - Leucine zipper domain | 0.0002498 | DIRECT |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.0008923 | DIRECT |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.001298 | INHERITED FROM: Benzoates |
82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0.001889 | INHERITED FROM: Benzoates || Benzamides |
49562,49562
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.003423 | INHERITED FROM: Diethylhexyl Phthalate |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.005449 | INHERITED FROM: butylidenephthalide || Phthalic Anhydrides |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.006745 | INHERITED FROM: Phenylbutyrates |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0.008713 | INHERITED FROM: lumiracoxib || tamibarotene || entinostat |
47986,52129
47986 - DEATH domain
52129 - Caspase-like | 0.009839 | INHERITED FROM: carboxycinnamic acid bishydroxamide || Diclofenac || Hydroxybenzoates || dehydroxymethylepoxyquinomicin || Phthalimides || Cyclohexanecarboxylic Acids || Phenylacetates || NCX 4040 || Aminobenzoates || propylparaben || Cinnamates || Parabens || Anacardic Acids || Imatinib Mesylate |
46785,144074
46785 - "Winged helix" DNA-binding domain
144074 - E2F-DP heterodimerization region | 0.009839 | INHERITED FROM: Diclofenac || Caffeic Acids || Phenylacetates || Cinnamates || UF010 compound || Eugenol |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.01174 | INHERITED FROM: pomalidomide || Benzamides |
57184,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0.01389 | INHERITED FROM: entinostat |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.01748 | INHERITED FROM: aurin || 4-phenylbutyric acid || Cyclohexanecarboxylic Acids || Chloromercuribenzoates || Phenylbutyrates |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.02165 | INHERITED FROM: 4-(3-(1-adamantyl)-4-hydroxyphenyl)-3-chlorocinnamic acid || Hydroxybenzoates || Phthalimides || Aspirin || Ibuprofen || Phenylpropionates || Parabens |
56112,47769
56112 - Protein kinase-like (PK-like)
47769 - SAM/Pointed domain | 0.0219 | INHERITED FROM: 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0.02571 | INHERITED FROM: Hydroxybenzoates || Aspirin || Cyclohexanecarboxylic Acids || Eugenol |
54897,52743
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like | 0.02748 | INHERITED FROM: Aspirin |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.02748 | INHERITED FROM: Diclofenac || Benzocaine || Hydroxybenzoates || para-Aminobenzoates || Aminobenzoates || butamben |
57184,49899
57184 - Growth factor receptor domain
49899 - Concanavalin A-like lectins/glucanases | 0.02748 | INHERITED FROM: Benzamides || 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide |
47986,47986
47986 - DEATH domain
47986 - DEATH domain | 0.03085 | INHERITED FROM: Diclofenac || Hydroxybenzoates || Aspirin |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0.03095 | INHERITED FROM: Diclofenac || Benzocaine || Hydroxybenzoates || Aminobenzoates || butylbenzyl phthalate || butamben |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 0.03185 | INHERITED FROM: Diclofenac || apple polyphenol extract || methyleugenol || Fenamates || Phenylacetates || Aminobenzoates || ortho-Aminobenzoates || Eugenol |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0.04279 | INHERITED FROM: Diclofenac || Phenylacetates |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.0552 | INHERITED FROM: butylidenephthalide || Phthalic Anhydrides |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0.06599 | INHERITED FROM: Diclofenac || Aspirin || Phenylacetates || Cinnamates || Salicylates || Eugenol |
52743,49785
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0.06599 | INHERITED FROM: Aspirin || Salicylates |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0.06599 | INHERITED FROM: Diclofenac || Aspirin || Phenylacetates || Cinnamates || Salicylates || Eugenol |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0.06599 | INHERITED FROM: Diclofenac || Aspirin || Phenylacetates || Cinnamates || Salicylates || Eugenol |
52799,52799
52799 - (Phosphotyrosine protein) phosphatases II
52799 - (Phosphotyrosine protein) phosphatases II | 0.08447 | INHERITED FROM: Aminobenzoates || 2-(oxalylamino)benzoic acid || ortho-Aminobenzoates |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0.09759 | INHERITED FROM: Caffeic Acids || caffeic acid phenethyl ester |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.1372 | INHERITED FROM: Aspirin |
57184,49265
57184 - Growth factor receptor domain
49265 - Fibronectin type III | 0.1516 | INHERITED FROM: Chloromercuribenzoates || Chlorobenzoates || Mercuribenzoates |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.1766 | INHERITED FROM: Lenalidomide |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.2033 | INHERITED FROM: Diclofenac || 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid || Hydroxybenzoates || Aspirin || Phenylacetates || Parabens || caffeic acid phenethyl ester |
52821,52799
52821 - Rhodanese/Cell cycle control phosphatase
52799 - (Phosphotyrosine protein) phosphatases II | 0.2048 | INHERITED FROM: Phthalimides || Chloromercuribenzoates || Thalidomide |
52540,90123
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0.2079 | INHERITED FROM: Aspirin |
81296,48239
81296 - E set domains
48239 - Terpenoid cyclases/Protein prenyltransferases | 0.226 | INHERITED FROM: Diethylhexyl Phthalate |
46565,57938
46565 - Chaperone J-domain
57938 - DnaJ/Hsp40 cysteine-rich domain | 0.226 | INHERITED FROM: Diclofenac || Phenylacetates |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.2391 | INHERITED FROM: Bezafibrate || Imatinib Mesylate |
103473,100895
103473 - MFS general substrate transporter
100895 - Kazal-type serine protease inhibitors | 0.2482 | INHERITED FROM: Benzilates || trospium chloride || Phenylacetates || Diphenylacetic Acids |
51905,55424
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.2601 | INHERITED FROM: Caffeic Acids || isoeugenol || Cinnamates || Eugenol |
52540,50447
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins | 0.2615 | INHERITED FROM: butylidenephthalide || Phthalic Anhydrides |
81301,81631
81301 - Nucleotidyltransferase
81631 - PAP/OAS1 substrate-binding domain | 0.2667 | INHERITED FROM: tamibarotene |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.3216 | INHERITED FROM: Hydroxybenzoates || tamibarotene || Aspirin || Imatinib Mesylate |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0.3702 | INHERITED FROM: 3-caffeoyl-4-dihydrocaffeoylquinic acid || Cyclohexanecarboxylic Acids || Ibuprofen || Chlorogenic Acid |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0.388 | INHERITED FROM: Diclofenac || Phenylacetates |
49493,49493
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0.4339 | INHERITED FROM: Diclofenac || Phenylacetates |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0.4339 | INHERITED FROM: Diclofenac || tamibarotene || Phenylacetates |
81324,81324
81324 - Voltage-gated potassium channels
81324 - Voltage-gated potassium channels | 0.4667 | INHERITED FROM: Mefenamic Acid || Niflumic Acid || Flufenamic Acid || Fenamates || Aminobenzoates || ortho-Aminobenzoates |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0.4967 | INHERITED FROM: tamibarotene || Imatinib Mesylate |
46579,64593
46579 - Prefoldin
64593 - Intermediate filament protein, coiled coil region | 0.4972 | INHERITED FROM: ethyl-p-((E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-1-propenyl)benzoic acid |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0.5296 | INHERITED FROM: aurin || 4-phenylbutyric acid || Phenylbutyrates |
50677,52374
50677 - ValRS/IleRS/LeuRS editing domain
52374 - Nucleotidylyl transferase | 0.6568 | INHERITED FROM: Ibuprofen || Phenylpropionates |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.7732 | INHERITED FROM: 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0.8585 | INHERITED FROM: 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.9405 | INHERITED FROM: 4-chloro-N-(2-(2-thienyl)imidazo(1,2-a)pyridin-3-yl)benzamide || benzamide |
64593,64593
64593 - Intermediate filament protein, coiled coil region
64593 - Intermediate filament protein, coiled coil region | 1 | INHERITED FROM: ethyl-p-((E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-1-propenyl)benzoic acid |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 1 | INHERITED FROM: pomalidomide |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
103647,103647
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat | 0 | Direct |
69012,55874
69012 - alpha-ketoacid dehydrogenase kinase, N-terminal domain
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | Direct |
53738,55957
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | Direct |
53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | Direct |
53223,51735
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
48726,56112
48726 - Immunoglobulin
56112 - Protein kinase-like (PK-like) | 0 | Direct |
57184,57610
57184 - Growth factor receptor domain
57610 - Thyroglobulin type-1 domain | 0 | Direct |
51905,47576
51905 - FAD/NAD(P)-binding domain
47576 - Calponin-homology domain, CH-domain | 0 | Direct |
57440,56436
57440 - Kringle-like
56436 - C-type lectin-like | 0 | Direct |
-7,56112
-7 - CATH
56112 - Protein kinase-like (PK-like) | 0 | Direct |
47668,47473
47668 - N-terminal domain of cbl (N-cbl)
47473 - EF-hand | 0 | Direct |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
48350,50044
48350 - GTPase activation domain, GAP
50044 - SH3-domain | 0 | Direct |
49899,63887
49899 - Concanavalin A-like lectins/glucanases
63887 - P-domain of calnexin/calreticulin | 0 | Direct |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | Direct |
57196,57581
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0 | Direct |
50156,52540
50156 - PDZ domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0 | Direct |
46785,158702
46785 - "Winged helix" DNA-binding domain
158702 - Sec63 N-terminal domain-like | 0 | Direct |
117839,56399
117839 - WWE domain
56399 - ADP-ribosylation | 0 | Direct |
52980,47781
52980 - Restriction endonuclease-like
47781 - RuvA domain 2-like | 0 | Direct |
57581,57581
57581 - TB module/8-cys domain
57581 - TB module/8-cys domain | 0 | Direct |
100895,50494
100895 - Kazal-type serine protease inhibitors
50494 - Trypsin-like serine proteases | 0 | Direct |
54236,57889
54236 - Ubiquitin-like
57889 - Cysteine-rich domain | 0 | Direct |
57581,57196
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0 | Direct |
103647,49899
103647 - TSP type-3 repeat
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
81324,53850
81324 - Voltage-gated potassium channels
53850 - Periplasmic binding protein-like II | 0 | Direct |
49785,53187
49785 - Galactose-binding domain-like
53187 - Zn-dependent exopeptidases | 0 | Direct |
141673,50800
141673 - MOSC N-terminal domain-like
50800 - PK beta-barrel domain-like | 0 | Direct |
49417,47719
49417 - p53-like transcription factors
47719 - p53 tetramerization domain | 0 | Direct |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | Direct |
53300,49265
53300 - vWA-like
49265 - Fibronectin type III | 0 | Direct |
56176,55103
56176 - FAD-binding/transporter-associated domain-like
55103 - FAD-linked oxidases, C-terminal domain | 0 | Direct |
74924,74924
74924 - Cap-Gly domain
74924 - Cap-Gly domain | 0 | Direct |
53300,49899
53300 - vWA-like
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
57184,57581
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain | 0 | Direct |
57414,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like | 0 | Direct |
54826,51604
54826 - Enolase N-terminal domain-like
51604 - Enolase C-terminal domain-like | 0 | Direct |
47005,52777
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
52777 - CoA-dependent acyltransferases | 0 | Direct |
81324,81327
81324 - Voltage-gated potassium channels
81327 - Small-conductance potassium channel | 0 | Direct |
50729,46785
50729 - PH domain-like
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
53300,69179
53300 - vWA-like
69179 - Integrin domains | 0 | Direct |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
100934,100934
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
57581,57184
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain | 0 | Direct |
52540,53254
52540 - P-loop containing nucleoside triphosphate hydrolases
53254 - Phosphoglycerate mutase-like | 0 | Direct |
49562,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain | 0 | Direct |
51230,47005
51230 - Single hybrid motif
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | Direct |
161111,160240
161111 - Cation efflux protein transmembrane domain-like
160240 - Cation efflux protein cytoplasmic domain-like | 0 | Direct |
47473,57610
47473 - EF-hand
57610 - Thyroglobulin type-1 domain | 0 | Direct |
55550,57850
55550 - SH2 domain
57850 - RING/U-box | 0 | Direct |
53850,53850
53850 - Periplasmic binding protein-like II
53850 - Periplasmic binding protein-like II | 0 | Direct |
69572,69572
69572 - Activating enzymes of the ubiquitin-like proteins
69572 - Activating enzymes of the ubiquitin-like proteins | 0 | Direct |
49695,50370
49695 - gamma-Crystallin-like
50370 - Ricin B-like lectins | 0 | Direct |
50370,57440
50370 - Ricin B-like lectins
57440 - Kringle-like | 0 | Direct |
47473,55550
47473 - EF-hand
55550 - SH2 domain | 0 | Direct |
100920,100934
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
56436,57535
56436 - C-type lectin-like
57535 - Complement control module/SCR domain | 0 | Direct |
48726,82895
48726 - Immunoglobulin
82895 - TSP-1 type 1 repeat | 0 | Direct |
57889,49562
57889 - Cysteine-rich domain
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
57196,69687
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0 | Direct |
52540,-7
52540 - P-loop containing nucleoside triphosphate hydrolases
-7 - CATH | 0 | Direct |
63501,50242
63501 - Frizzled cysteine-rich domain
50242 - TIMP-like | 0 | Direct |
100895,100895
100895 - Kazal-type serine protease inhibitors
100895 - Kazal-type serine protease inhibitors | 0 | Direct |
52540,51045
52540 - P-loop containing nucleoside triphosphate hydrolases
51045 - WW domain | 0 | Direct |
56112,56112
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0 | Direct |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.0001543 | Direct |
47454,57959
47454 - A DNA-binding domain in eukaryotic transcription factors
57959 - Leucine zipper domain | 0.0002498 | Direct |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.0008923 | Direct |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.001298 | Inherited |
82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0.001889 | Inherited |
49562,49562
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.003423 | Inherited |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.005449 | Inherited |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.006745 | Inherited |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0.008713 | Inherited |
47986,52129
47986 - DEATH domain
52129 - Caspase-like | 0.009839 | Inherited |
46785,144074
46785 - "Winged helix" DNA-binding domain
144074 - E2F-DP heterodimerization region | 0.009839 | Inherited |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.01174 | Inherited |
57184,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0.01389 | Inherited |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.01748 | Inherited |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.02165 | Inherited |
56112,47769
56112 - Protein kinase-like (PK-like)
47769 - SAM/Pointed domain | 0.0219 | Inherited |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0.02571 | Inherited |
54897,52743
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like | 0.02748 | Inherited |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.02748 | Inherited |
57184,49899
57184 - Growth factor receptor domain
49899 - Concanavalin A-like lectins/glucanases | 0.02748 | Inherited |
47986,47986
47986 - DEATH domain
47986 - DEATH domain | 0.03085 | Inherited |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0.03095 | Inherited |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 0.03185 | Inherited |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0.04279 | Inherited |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.0552 | Inherited |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0.06599 | Inherited |
52743,49785
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0.06599 | Inherited |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0.06599 | Inherited |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0.06599 | Inherited |
52799,52799
52799 - (Phosphotyrosine protein) phosphatases II
52799 - (Phosphotyrosine protein) phosphatases II | 0.08447 | Inherited |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0.09759 | Inherited |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0.1372 | Inherited |
57184,49265
57184 - Growth factor receptor domain
49265 - Fibronectin type III | 0.1516 | Inherited |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.1766 | Inherited |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.2033 | Inherited |
52821,52799
52821 - Rhodanese/Cell cycle control phosphatase
52799 - (Phosphotyrosine protein) phosphatases II | 0.2048 | Inherited |
52540,90123
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0.2079 | Inherited |
81296,48239
81296 - E set domains
48239 - Terpenoid cyclases/Protein prenyltransferases | 0.226 | Inherited |
46565,57938
46565 - Chaperone J-domain
57938 - DnaJ/Hsp40 cysteine-rich domain | 0.226 | Inherited |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.2391 | Inherited |
103473,100895
103473 - MFS general substrate transporter
100895 - Kazal-type serine protease inhibitors | 0.2482 | Inherited |
51905,55424
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0.2601 | Inherited |
52540,50447
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins | 0.2615 | Inherited |
81301,81631
81301 - Nucleotidyltransferase
81631 - PAP/OAS1 substrate-binding domain | 0.2667 | Inherited |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.3216 | Inherited |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0.3702 | Inherited |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0.388 | Inherited |
49493,49493
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0.4339 | Inherited |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0.4339 | Inherited |
81324,81324
81324 - Voltage-gated potassium channels
81324 - Voltage-gated potassium channels | 0.4667 | Inherited |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0.4967 | Inherited |
46579,64593
46579 - Prefoldin
64593 - Intermediate filament protein, coiled coil region | 0.4972 | Inherited |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0.5296 | Inherited |
50677,52374
50677 - ValRS/IleRS/LeuRS editing domain
52374 - Nucleotidylyl transferase | 0.6568 | Inherited |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.7732 | Inherited |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0.8585 | Inherited |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.9405 | Inherited |
64593,64593
64593 - Intermediate filament protein, coiled coil region
64593 - Intermediate filament protein, coiled coil region | 1 | Inherited |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 1 | Inherited |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Triple) in N- to C-terminal order( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
48726,49265,56112
48726 - Immunoglobulin
49265 - Fibronectin type III
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
53738,53738,55957
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
48726,82895,82895
48726 - Immunoglobulin
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
50729,55550,56112
50729 - PH domain-like
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
49562,57889,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0 | DIRECT |
63737,55486,48371
63737 - Leukotriene A4 hydrolase N-terminal domain
55486 - Metalloproteases ("zincins"), catalytic domain
48371 - ARM repeat | 0 | DIRECT |
53067,53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0 | DIRECT |
57196,57196,69687
57196 - EGF/Laminin
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0 | DIRECT |
48726,48726,82895
48726 - Immunoglobulin
48726 - Immunoglobulin
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
57581,57196,57581
57581 - TB module/8-cys domain
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0 | DIRECT |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
52540,52540,46785
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
57184,57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | DIRECT |
52540,46785,158702
52540 - P-loop containing nucleoside triphosphate hydrolases
46785 - "Winged helix" DNA-binding domain
158702 - Sec63 N-terminal domain-like | 0 | DIRECT |
57924,57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
100895,50494,50156
100895 - Kazal-type serine protease inhibitors
50494 - Trypsin-like serine proteases
50156 - PDZ domain-like | 0 | DIRECT |
53738,53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | DIRECT |
57414,57440,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like
57440 - Kringle-like | 0 | DIRECT |
57184,57581,57184
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain | 0 | DIRECT |
57196,57184,49899
57196 - EGF/Laminin
57184 - Growth factor receptor domain
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
51230,47005,52777
51230 - Single hybrid motif
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
52777 - CoA-dependent acyltransferases | 0 | DIRECT |
103647,103647,103647
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat | 0 | DIRECT |
57581,57196,57196
57581 - TB module/8-cys domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | DIRECT |
63763,57903,47370
63763 - SAND domain-like
57903 - FYVE/PHD zinc finger
47370 - Bromodomain | 0 | DIRECT |
55550,56112,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
57184,57184,57581
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain | 0 | DIRECT |
57196,57581,57196
57196 - EGF/Laminin
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0 | DIRECT |
47668,47473,55550
47668 - N-terminal domain of cbl (N-cbl)
47473 - EF-hand
55550 - SH2 domain | 0 | DIRECT |
57184,57581,57196
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0 | DIRECT |
52540,51045,51045
52540 - P-loop containing nucleoside triphosphate hydrolases
51045 - WW domain
51045 - WW domain | 0 | DIRECT |
57184,57581,57581
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain
57581 - TB module/8-cys domain | 0 | DIRECT |
49265,49265,53300
49265 - Fibronectin type III
49265 - Fibronectin type III
53300 - vWA-like | 0 | DIRECT |
57184,100895,50494
57184 - Growth factor receptor domain
100895 - Kazal-type serine protease inhibitors
50494 - Trypsin-like serine proteases | 0 | DIRECT |
57889,57889,49562
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
57196,57196,57581
57196 - EGF/Laminin
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0 | DIRECT |
47986,47986,52129
47986 - DEATH domain
47986 - DEATH domain
52129 - Caspase-like | 0 | DIRECT |
100895,47473,57610
100895 - Kazal-type serine protease inhibitors
47473 - EF-hand
57610 - Thyroglobulin type-1 domain | 0 | DIRECT |
57196,57581,57184
57196 - EGF/Laminin
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain | 0 | DIRECT |
75399,75399,75399
75399 - Plakin repeat
75399 - Plakin repeat
75399 - Plakin repeat | 0 | DIRECT |
57440,57440,50494
57440 - Kringle-like
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0 | DIRECT |
47473,55550,57850
47473 - EF-hand
55550 - SH2 domain
57850 - RING/U-box | 0 | DIRECT |
53067,100920,100934
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
57196,57196,90193
57196 - EGF/Laminin
57196 - EGF/Laminin
90193 - Notch domain | 0 | DIRECT |
100895,100895,100895
100895 - Kazal-type serine protease inhibitors
100895 - Kazal-type serine protease inhibitors
100895 - Kazal-type serine protease inhibitors | 0 | DIRECT |
57196,57535,57535
57196 - EGF/Laminin
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | DIRECT |
50156,52540,51045
50156 - PDZ domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
51045 - WW domain | 0 | DIRECT |
103647,103647,49899
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
57184,57184,57196
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | DIRECT |
50729,50729,57863
50729 - PH domain-like
50729 - PH domain-like
57863 - ArfGap/RecO-like zinc finger | 0 | DIRECT |
57440,56436,56436
57440 - Kringle-like
56436 - C-type lectin-like
56436 - C-type lectin-like | 0 | DIRECT |
57581,57184,57581
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain | 0 | DIRECT |
57581,57184,57184
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | DIRECT |
50370,57440,56436
50370 - Ricin B-like lectins
57440 - Kringle-like
56436 - C-type lectin-like | 0 | DIRECT |
50729,50729,48350
50729 - PH domain-like
50729 - PH domain-like
48350 - GTPase activation domain, GAP | 0 | DIRECT |
49785,53187,49464
49785 - Galactose-binding domain-like
53187 - Zn-dependent exopeptidases
49464 - Carboxypeptidase regulatory domain-like | 0 | DIRECT |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.004118 | INHERITED FROM: Phenylbutyrates |
82895,82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0.004306 | INHERITED FROM: Benzoates || Benzamides |
52540,50447,50465
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.005449 | INHERITED FROM: butylidenephthalide || Phthalic Anhydrides |
57196,57184,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.011 | INHERITED FROM: Benzoates || Phenylbutyrates |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.01288 | INHERITED FROM: Lenalidomide |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.01748 | INHERITED FROM: aurin || 4-phenylbutyric acid || Cyclohexanecarboxylic Acids || Chloromercuribenzoates || Phenylbutyrates |
57440,57440,57440
57440 - Kringle-like
57440 - Kringle-like
57440 - Kringle-like | 0.03085 | INHERITED FROM: Hydroxybenzoates || Phthalimides || Aspirin || Thalidomide || Salicylates |
57586,57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.04279 | INHERITED FROM: Hydroxybenzoates || Phthalimides || Aspirin || propylparaben || Thalidomide |
47459,55785,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.04279 | INHERITED FROM: Diclofenac || Benzocaine || Hydroxybenzoates || para-Aminobenzoates || Aminobenzoates || butamben |
54897,52743,49785
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0.06599 | INHERITED FROM: Aspirin || Salicylates |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0.06599 | INHERITED FROM: Diclofenac || Aspirin || Phenylacetates || Cinnamates || Salicylates || Eugenol |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0.06599 | INHERITED FROM: Diclofenac || Aspirin || Phenylacetates || Cinnamates || Salicylates || Eugenol |
52540,90123,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.2079 | INHERITED FROM: Aspirin |
90123,52540,90123
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0.2079 | INHERITED FROM: Aspirin |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0.4339 | INHERITED FROM: Diclofenac || tamibarotene || Phenylacetates |
50044,55550,56112
50044 - SH3-domain
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.5902 | INHERITED FROM: Hydroxybenzoates || tamibarotene || Imatinib Mesylate |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.8585 | INHERITED FROM: 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
48726,49265,56112
48726 - Immunoglobulin
49265 - Fibronectin type III
56112 - Protein kinase-like (PK-like) | 0 | Direct |
53738,53738,55957
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | Direct |
48726,82895,82895
48726 - Immunoglobulin
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | Direct |
50729,55550,56112
50729 - PH domain-like
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | Direct |
49562,57889,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0 | Direct |
63737,55486,48371
63737 - Leukotriene A4 hydrolase N-terminal domain
55486 - Metalloproteases ("zincins"), catalytic domain
48371 - ARM repeat | 0 | Direct |
53067,53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0 | Direct |
57196,57196,69687
57196 - EGF/Laminin
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0 | Direct |
48726,48726,82895
48726 - Immunoglobulin
48726 - Immunoglobulin
82895 - TSP-1 type 1 repeat | 0 | Direct |
57581,57196,57581
57581 - TB module/8-cys domain
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0 | Direct |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | Direct |
52540,52540,46785
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
57184,57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | Direct |
52540,46785,158702
52540 - P-loop containing nucleoside triphosphate hydrolases
46785 - "Winged helix" DNA-binding domain
158702 - Sec63 N-terminal domain-like | 0 | Direct |
57924,57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
100895,50494,50156
100895 - Kazal-type serine protease inhibitors
50494 - Trypsin-like serine proteases
50156 - PDZ domain-like | 0 | Direct |
53738,53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | Direct |
57414,57440,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like
57440 - Kringle-like | 0 | Direct |
57184,57581,57184
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain | 0 | Direct |
57196,57184,49899
57196 - EGF/Laminin
57184 - Growth factor receptor domain
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
51230,47005,52777
51230 - Single hybrid motif
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
52777 - CoA-dependent acyltransferases | 0 | Direct |
103647,103647,103647
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat | 0 | Direct |
57581,57196,57196
57581 - TB module/8-cys domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | Direct |
63763,57903,47370
63763 - SAND domain-like
57903 - FYVE/PHD zinc finger
47370 - Bromodomain | 0 | Direct |
55550,56112,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0 | Direct |
57184,57184,57581
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain | 0 | Direct |
57196,57581,57196
57196 - EGF/Laminin
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0 | Direct |
47668,47473,55550
47668 - N-terminal domain of cbl (N-cbl)
47473 - EF-hand
55550 - SH2 domain | 0 | Direct |
57184,57581,57196
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0 | Direct |
52540,51045,51045
52540 - P-loop containing nucleoside triphosphate hydrolases
51045 - WW domain
51045 - WW domain | 0 | Direct |
57184,57581,57581
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain
57581 - TB module/8-cys domain | 0 | Direct |
49265,49265,53300
49265 - Fibronectin type III
49265 - Fibronectin type III
53300 - vWA-like | 0 | Direct |
57184,100895,50494
57184 - Growth factor receptor domain
100895 - Kazal-type serine protease inhibitors
50494 - Trypsin-like serine proteases | 0 | Direct |
57889,57889,49562
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
57196,57196,57581
57196 - EGF/Laminin
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0 | Direct |
47986,47986,52129
47986 - DEATH domain
47986 - DEATH domain
52129 - Caspase-like | 0 | Direct |
100895,47473,57610
100895 - Kazal-type serine protease inhibitors
47473 - EF-hand
57610 - Thyroglobulin type-1 domain | 0 | Direct |
57196,57581,57184
57196 - EGF/Laminin
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain | 0 | Direct |
75399,75399,75399
75399 - Plakin repeat
75399 - Plakin repeat
75399 - Plakin repeat | 0 | Direct |
57440,57440,50494
57440 - Kringle-like
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0 | Direct |
47473,55550,57850
47473 - EF-hand
55550 - SH2 domain
57850 - RING/U-box | 0 | Direct |
53067,100920,100934
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
57196,57196,90193
57196 - EGF/Laminin
57196 - EGF/Laminin
90193 - Notch domain | 0 | Direct |
100895,100895,100895
100895 - Kazal-type serine protease inhibitors
100895 - Kazal-type serine protease inhibitors
100895 - Kazal-type serine protease inhibitors | 0 | Direct |
57196,57535,57535
57196 - EGF/Laminin
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | Direct |
50156,52540,51045
50156 - PDZ domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
51045 - WW domain | 0 | Direct |
103647,103647,49899
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
57184,57184,57196
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | Direct |
50729,50729,57863
50729 - PH domain-like
50729 - PH domain-like
57863 - ArfGap/RecO-like zinc finger | 0 | Direct |
57440,56436,56436
57440 - Kringle-like
56436 - C-type lectin-like
56436 - C-type lectin-like | 0 | Direct |
57581,57184,57581
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain | 0 | Direct |
57581,57184,57184
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | Direct |
50370,57440,56436
50370 - Ricin B-like lectins
57440 - Kringle-like
56436 - C-type lectin-like | 0 | Direct |
50729,50729,48350
50729 - PH domain-like
50729 - PH domain-like
48350 - GTPase activation domain, GAP | 0 | Direct |
49785,53187,49464
49785 - Galactose-binding domain-like
53187 - Zn-dependent exopeptidases
49464 - Carboxypeptidase regulatory domain-like | 0 | Direct |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.004118 | Inherited |
82895,82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0.004306 | Inherited |
52540,50447,50465
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0.005449 | Inherited |
57196,57184,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.011 | Inherited |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.01288 | Inherited |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.01748 | Inherited |
57440,57440,57440
57440 - Kringle-like
57440 - Kringle-like
57440 - Kringle-like | 0.03085 | Inherited |
57586,57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like
57586 - TNF receptor-like | 0.04279 | Inherited |
47459,55785,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.04279 | Inherited |
54897,52743,49785
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0.06599 | Inherited |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0.06599 | Inherited |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0.06599 | Inherited |
52540,90123,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.2079 | Inherited |
90123,52540,90123
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0.2079 | Inherited |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0.4339 | Inherited |
50044,55550,56112
50044 - SH3-domain
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.5902 | Inherited |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.8585 | Inherited |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Plot distribution on species Tree Of Life (sTOL) for Superfamily and/or Family domains annotated by this CC term
 |
Plot tree as:
| |
Download Newick format tree:
|
( show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Plot distribution on species Tree Of Life (sTOL) for single supra-domains annotated by this CC term
|
Plot tree as:
| |
Download Newick format tree:
| |
Browsing in TREE OF LIFE:
|
( show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
|
|
> BO Hierarchy > Acids, Carbocyclic
