Hormone receptor domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Small proteins [ 56992] (90)
• Fold: Hormone receptor domain [ 111417]
• Superfamily: Hormone receptor domain [ 111418]
• Family: Hormone receptor domain [ 111419] (2)

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Family statistics

	Genomes (65)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	268	802	2
Proteins	268	802	2

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	cognitive disorder	0.1196	1.151	--	INHERITED FROM: anxiety disorder
Disease Ontology (DO)	disease of mental health	0.3074	1.036	Moderately Informative	INHERITED FROM: anxiety disorder
Disease Ontology (DO)	anxiety disorder	0.00004726	2.212	Highly Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Mode of Inheritance (MI)	Autosomal dominant inheritance	0	0.516	Least Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal circulating hormone level	0.0002354	1.241	--	DIRECT
Mammalian Phenotype (MP)	abnormal locomotor behavior	0.0002653	1.649	--	DIRECT
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.001509	0.3626	--	INHERITED FROM: abnormal circulating hormone level || abnormal homeostasis || abnormal hormone level
Mammalian Phenotype (MP)	behavior/neurological phenotype	0.005093	0.8178	--	INHERITED FROM: abnormal locomotor behavior || abnormal locomotor activation
Mammalian Phenotype (MP)	increased body weight	0.04778	1.758	--	INHERITED FROM: obese
Mammalian Phenotype (MP)	increased body size	0.05386	1.758	--	INHERITED FROM: obese
Mammalian Phenotype (MP)	increased total tissue mass	0.05616	1.758	--	INHERITED FROM: obese
Mammalian Phenotype (MP)	abnormal motor capabilities/coordination/movement	0.07	1.205	--	INHERITED FROM: abnormal locomotor activation || abnormal locomotor behavior
Mammalian Phenotype (MP)	abnormal postnatal growth/weight/body size	0.1763	0.8956	--	INHERITED FROM: obese
Mammalian Phenotype (MP)	abnormal body weight	0.2772	1.156	--	INHERITED FROM: obese
Mammalian Phenotype (MP)	abnormal blood homeostasis	0.3242	0.6893	--	INHERITED FROM: abnormal circulating hormone level
Mammalian Phenotype (MP)	abnormal total tissue mass	0.5954	1.188	--	INHERITED FROM: obese
Mammalian Phenotype (MP)	abnormal homeostasis	0.0003055	0.4926	Least Informative	DIRECT
Mammalian Phenotype (MP)	growth/size/body region phenotype	0.1593	0.6254	Least Informative	INHERITED FROM: obese
Mammalian Phenotype (MP)	abnormal hormone level	0.0002311	1.141	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal body composition	0.09532	1.112	Moderately Informative	INHERITED FROM: obese
Mammalian Phenotype (MP)	abnormal body size	0.4925	1.001	Moderately Informative	INHERITED FROM: obese
Mammalian Phenotype (MP)	abnormal behavior	1	0.855	Moderately Informative	INHERITED FROM: abnormal locomotor behavior || abnormal locomotor activation
Mammalian Phenotype (MP)	abnormal voluntary movement	0.07398	1.489	Informative	INHERITED FROM: abnormal locomotor activation || abnormal locomotor behavior
Mammalian Phenotype (MP)	abnormal locomotor activation	0.00002397	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	obese	0.0004688	2.001	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	growth variant	0	0.3438	--	DIRECT
Worm Phenotype (WP)	developmental timing variant	0	0.4548	--	DIRECT
Worm Phenotype (WP)	general pace of development variant	0	0.4786	--	DIRECT
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	retarded heterochronic variations	0	0.4548	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	larval development variant	0	0.4322	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	developmental growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	larval growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	sterile progeny	0	0.6547	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || developmental growth variant || retarded heterochronic variations || larval lethal || reproductive system physiology variant || organism homeostasis metabolism variant || lethal || larval development variant || sterile progeny || organism physiology variant || progeny variant || slow growth || development variant || developmental timing variant || hermaphrodite sterile || growth variant || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || larval growth variant || general pace of development variant || fertility variant || postembryonic development variant || larval arrest || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile || sterile progeny
Worm Phenotype (WP)	slow growth	0	0.4945	Least Informative	DIRECT
Worm Phenotype (WP)	larval lethal	0	0.5727	Least Informative	DIRECT
Worm Phenotype (WP)	larval arrest	0	0.4991	Least Informative	DIRECT
Worm Phenotype (WP)	progeny variant	0	0.6514	Least Informative	DIRECT

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.06546	--	DIRECT
Fly Phenotype (FP)	circadian behavior defective	0.0004305	1.908	--	DIRECT
Fly Phenotype (FP)	circadian rhythm defective	0.0000265	1.607	Informative	DIRECT
Fly Phenotype (FP)	behavior defective	0.004469	1.306	Informative	INHERITED FROM: circadian behavior defective
Fly Phenotype (FP)	hypoactive	0.000007434	1.908	Highly Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	compound organ	0	0.4299	--	DIRECT
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.1857	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1532	--	DIRECT
Zebrafish Anatomy (ZA)	blood vasculature	0.008984	1.626	--	INHERITED FROM: artery
Zebrafish Anatomy (ZA)	blood vessel	0.03164	1.626	--	INHERITED FROM: artery
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: cell || anatomical system || multi-tissue structure || anatomical group || whole organism || artery || compound organ
Zebrafish Anatomy (ZA)	multi-tissue structure	0	0.5848	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	cell	0	0.6388	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	cavitated compound organ	0.769	0.5123	Least Informative	INHERITED FROM: artery
Zebrafish Anatomy (ZA)	cardiovascular system	0.1541	1.216	Moderately Informative	INHERITED FROM: artery
Zebrafish Anatomy (ZA)	vasculature	0.04082	1.471	Informative	INHERITED FROM: artery
Zebrafish Anatomy (ZA)	artery	0.0007073	1.869	Highly Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: multicellular anatomical structure
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage 1	0.0000005326	2.785	--	DIRECT
Xenopus DEvelopment stage (XDE)	embryonic stage	0.009989	1.006	Moderately Informative	INHERITED FROM: NF stage 1

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