Forming carbon-nitrogen bonds

Enzyme Commission (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed. To navigate hierarchical structure of EC, we display all parental EC terms to the current EC term of interest ordered by their shortest distances to the current term. Also, only direct children EC terms of the current EC term are listed.

Structural Classification of Proteins (SCOP)
SCOP classifies evolutionary-related domains into Superfamily level and Family level. Accordingly, we have generated the domain-centric EC annotations for each of the three concepts at each of the two domain levels.

Structural Domain Enzyme Commission Ontology (SDEO)
As domain-centric ontology, SDEO only refers to those EC terms which are the most informative to annotate SCOP domains.

EC annotations for SCOP domains
For details, please visit Documentation: EC annotations for SCOP domains. Therein, we provide several relevant files (Data Availability) for the download, including an annotation file (i.e., Domain2EC.txt) and the corresponding ontology (i.e., SDEO.txt).

Supra-domain Enzyme Commission Ontology (SPEO)
As an extension, SPEO includes those EC terms which are the most informative to annotate supra-domains and individual SCOP domains at the Superfamily level.

EC annotations for Supra-domains
For details, please visit Documentation: EC annotations for Supra-domains. Therein, we provide several relevant files (Data Availability) for the download, including a annotation file (i.e., SP2EC.txt) and an ontology (i.e., SPEO.txt). For the sake of being browsable, listed below are those supra-domains (single, dual, triple, quad).

Supra-domains annotated to this EC term (Not in SPEO)
Highlighted in gray are those with FDR>0.001

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
52021,52317 52021 - Carbamoyl phosphate synthetase, small subunit N-terminal domain 52317 - Class I glutamine amidotransferase-like	0	DIRECT
51246,55326 51246 - Rudiment single hybrid motif 55326 - PurM N-terminal domain-like	0	DIRECT
52402,69864 52402 - Adenine nucleotide alpha hydrolases-like 69864 - Argininosuccinate synthetase, C-terminal domain	0	DIRECT
51984,53623 51984 - MurCD N-terminal domain 53623 - MurD-like peptide ligases, catalytic domain	0	DIRECT
52402,54810 52402 - Adenine nucleotide alpha hydrolases-like 54810 - GMP synthetase C-terminal dimerisation domain	0	DIRECT
55326,56042 55326 - PurM N-terminal domain-like 56042 - PurM C-terminal domain-like	0	DIRECT
51735,53623 51735 - NAD(P)-binding Rossmann-fold domains 53623 - MurD-like peptide ligases, catalytic domain	0	DIRECT
50891,160467 50891 - Cyclophilin-like 160467 - PH0987 N-terminal domain-like	0	DIRECT
54368,55931 54368 - Glutamine synthetase, N-terminal domain 55931 - Glutamine synthetase/guanido kinase	0	DIRECT
56059,51246 56059 - Glutathione synthetase ATP-binding domain-like 51246 - Rudiment single hybrid motif	0	DIRECT
109736,55326 109736 - FGAM synthase PurL, linker domain 55326 - PurM N-terminal domain-like	0	DIRECT
56059,52335 56059 - Glutathione synthetase ATP-binding domain-like 52335 - Methylglyoxal synthase-like	0	DIRECT
52440,56059 52440 - PreATP-grasp domain 56059 - Glutathione synthetase ATP-binding domain-like	0	DIRECT
56235,52402 56235 - N-terminal nucleophile aminohydrolases (Ntn hydrolases) 52402 - Adenine nucleotide alpha hydrolases-like	0	DIRECT
56037,53271 56037 - PheT/TilS domain 53271 - PRTase-like	0	DIRECT
54495,46934 54495 - UBC-like 46934 - UBA-like	0	DIRECT
55681,50037 55681 - Class II aaRS and biotin synthetases 50037 - C-terminal domain of transcriptional repressors	0	DIRECT
52402,82829 52402 - Adenine nucleotide alpha hydrolases-like 82829 - MesJ substrate recognition domain-like	0	DIRECT
56317,52402 56317 - Carbon-nitrogen hydrolase 52402 - Adenine nucleotide alpha hydrolases-like	0	DIRECT
56042,52317 56042 - PurM C-terminal domain-like 52317 - Class I glutamine amidotransferase-like	0	DIRECT
52374,52540 52374 - Nucleotidylyl transferase 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
56104,52255 56104 - SAICAR synthase-like 52255 - N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	0	DIRECT
52777,53474 52777 - CoA-dependent acyltransferases 53474 - alpha/beta-Hydrolases	0	DIRECT
55931,56059 55931 - Glutamine synthetase/guanido kinase 56059 - Glutathione synthetase ATP-binding domain-like	0	DIRECT
56059,52440 56059 - Glutathione synthetase ATP-binding domain-like 52440 - PreATP-grasp domain	0	DIRECT
53244,52440 53244 - MurD-like peptide ligases, peptide-binding domain 52440 - PreATP-grasp domain	0	DIRECT
56042,55326 56042 - PurM C-terminal domain-like 55326 - PurM N-terminal domain-like	0	DIRECT
82829,56037 82829 - MesJ substrate recognition domain-like 56037 - PheT/TilS domain	0	DIRECT
54001,56059 54001 - Cysteine proteinases 56059 - Glutathione synthetase ATP-binding domain-like	0	DIRECT
52335,51556 52335 - Methylglyoxal synthase-like 51556 - Metallo-dependent hydrolases	0	DIRECT
53623,53244 53623 - MurD-like peptide ligases, catalytic domain 53244 - MurD-like peptide ligases, peptide-binding domain	0	DIRECT
56042,53328 56042 - PurM C-terminal domain-like 53328 - Formyltransferase	0	DIRECT
48108,52440 48108 - Carbamoyl phosphate synthetase, large subunit connection domain 52440 - PreATP-grasp domain	0	DIRECT
52402,56037 52402 - Adenine nucleotide alpha hydrolases-like 56037 - PheT/TilS domain	0	DIRECT
52507,102645 52507 - Homo-oligomeric flavin-containing Cys decarboxylases, HFCD 102645 - CoaB-like	0	DIRECT
54810,54810 54810 - GMP synthetase C-terminal dimerisation domain 54810 - GMP synthetase C-terminal dimerisation domain	0	DIRECT
82697,109736 82697 - PurS-like 109736 - FGAM synthase PurL, linker domain	0	DIRECT
52540,52317 52540 - P-loop containing nucleoside triphosphate hydrolases 52317 - Class I glutamine amidotransferase-like	0	DIRECT
52317,52440 52317 - Class I glutamine amidotransferase-like 52440 - PreATP-grasp domain	0	DIRECT
160467,50891 160467 - PH0987 N-terminal domain-like 50891 - Cyclophilin-like	0	DIRECT
63418,53623 63418 - MurE/MurF N-terminal domain 53623 - MurD-like peptide ligases, catalytic domain	0	DIRECT
56059,53623 56059 - Glutathione synthetase ATP-binding domain-like 53623 - MurD-like peptide ligases, catalytic domain	0	DIRECT
50037,53067 50037 - C-terminal domain of transcriptional repressors 53067 - Actin-like ATPase domain	0	DIRECT
56059,48108 56059 - Glutathione synthetase ATP-binding domain-like 48108 - Carbamoyl phosphate synthetase, large subunit connection domain	0	DIRECT
52317,52402 52317 - Class I glutamine amidotransferase-like 52402 - Adenine nucleotide alpha hydrolases-like	0	DIRECT
52777,56801 52777 - CoA-dependent acyltransferases 56801 - Acetyl-CoA synthetase-like	0.000004619	DIRECT
56801,47336 56801 - Acetyl-CoA synthetase-like 47336 - ACP-like	0.00004227	DIRECT
47336,52777 47336 - ACP-like 52777 - CoA-dependent acyltransferases	0.0001024	DIRECT
46785,55681 46785 - "Winged helix" DNA-binding domain 55681 - Class II aaRS and biotin synthetases	0.00867	INHERITED FROM: Biotin--[acetyl-CoA-carboxylase] ligase \|\| Other carbon--nitrogen ligases
52777,52777 52777 - CoA-dependent acyltransferases 52777 - CoA-dependent acyltransferases	0.07004	INHERITED FROM: N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valin \|\| Acid--D-amino-acid ligases (peptide synthases)
51556,51338 51556 - Metallo-dependent hydrolases 51338 - Composite domain of metallo-dependent hydrolases	1	INHERITED FROM: Carbamoyl-phosphate synthase (glutamine-hydrolyzin
53223,51735 53223 - Aminoacid dehydrogenase-like, N-terminal domain 51735 - NAD(P)-binding Rossmann-fold domains	1	INHERITED FROM: Formate--tetrahydrofolate ligase
53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain	1	INHERITED FROM: Biotin--[acetyl-CoA-carboxylase] ligase
52374,47323 52374 - Nucleotidylyl transferase 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	1	INHERITED FROM: ligase

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Forming carbon-nitrogen bonds

Superfamily

Family

Supra-domain (including individual superfamily)