Aminoacid dehydrogenase-like, C-terminal domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: NAD(P)-binding Rossmann-fold domains [ 51734]
• Superfamily: NAD(P)-binding Rossmann-fold domains [ 51735] (12)
• Family: Aminoacid dehydrogenase-like, C-terminal domain [ 51883] (11)

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Family statistics

	Genomes (3,165)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	13,660	94,325	43
Proteins	13,643	94,248	43

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Glutamyl-tRNA reductase	0	2.264	--	DIRECT
Enzyme Commission (EC)	Acting on the CH-NH group of donors	0	1.279	--	DIRECT
Enzyme Commission (EC)	Malate dehydrogenase (oxaloacetate-decarboxylating	0	2.44	--	DIRECT
Enzyme Commission (EC)	Methenyltetrahydrofolate cyclohydrolase	0	2.44	--	DIRECT
Enzyme Commission (EC)	Malate dehydrogenase (oxaloacetate-decarboxylating	0	2.264	--	DIRECT
Enzyme Commission (EC)	Methylenetetrahydrofolate dehydrogenase (NADP(+))	0	2.44	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.01852	--	DIRECT
Enzyme Commission (EC)	Quinate/shikimate dehydrogenase	0.00000000001362	2.44	--	DIRECT
Enzyme Commission (EC)	Formate--tetrahydrofolate ligase	0.000009338	2.264	--	DIRECT
Enzyme Commission (EC)	Glutamate dehydrogenase (NAD(P)(+))	0.00001195	2.44	--	DIRECT
Enzyme Commission (EC)	Glutamate dehydrogenase (NADP(+))	0.00003398	2.44	--	DIRECT
Enzyme Commission (EC)	Carbon-oxygen lyases	1	0.8221	--	INHERITED FROM: 3-dehydroquinate dehydratase || 3-dehydroquinate synthase
Enzyme Commission (EC)	Transferases	1	0	--	INHERITED FROM: Shikimate kinase || 3-phosphoshikimate 1-carboxyvinyltransferase
Enzyme Commission (EC)	Transferring phosphorous-containing groups	1	0.2728	--	INHERITED FROM: Shikimate kinase
Enzyme Commission (EC)	Transferring alkyl or aryl groups, other than meth	1	1.185	--	INHERITED FROM: 3-phosphoshikimate 1-carboxyvinyltransferase
Enzyme Commission (EC)	Acting on the CH-OH group of donors	0.04261	0.935	--	INHERITED FROM: Quinate/shikimate dehydrogenase || With NAD(+) or NADP(+) as acceptor || Malate dehydrogenase (oxaloacetate-decarboxylating || Shikimate dehydrogenase || Malate dehydrogenase (oxaloacetate-decarboxylating
Enzyme Commission (EC)	Oxidoreductases	0	0.3212	Least Informative	DIRECT
Enzyme Commission (EC)	Ligases	1	0.7455	Least Informative	INHERITED FROM: Formate--tetrahydrofolate ligase
Enzyme Commission (EC)	Lyases	1	0.4956	Least Informative	INHERITED FROM: 3-dehydroquinate dehydratase || 3-dehydroquinate synthase
Enzyme Commission (EC)	Acting on carbon-nitrogen bonds, other than peptid	0	0.8435	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on the aldehyde or oxo group of donors	0	1.236	Moderately Informative	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	0.9853	Moderately Informative	DIRECT
Enzyme Commission (EC)	Forming carbon-nitrogen bonds	1	0.993	Moderately Informative	INHERITED FROM: Formate--tetrahydrofolate ligase
Enzyme Commission (EC)	Hydro-lyases	1	0.9853	Moderately Informative	INHERITED FROM: 3-dehydroquinate dehydratase
Enzyme Commission (EC)	Phosphotransferases with an alcohol group as accep	1	0.8381	Moderately Informative	INHERITED FROM: Shikimate kinase
Enzyme Commission (EC)	Transferring alkyl or aryl groups, other than meth	1	1.185	Moderately Informative	INHERITED FROM: 3-phosphoshikimate 1-carboxyvinyltransferase
Enzyme Commission (EC)	In cyclic amidines	0	1.462	Informative	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	1.511	Informative	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	1.662	Informative	DIRECT
Enzyme Commission (EC)	Other carbon--nitrogen ligases	1	1.462	Informative	INHERITED FROM: Formate--tetrahydrofolate ligase
Enzyme Commission (EC)	Acting on phosphates	0.01576	1.595	Informative	INHERITED FROM: 3-dehydroquinate synthase
Enzyme Commission (EC)	Acting on the CH-NH(2) group of donors	0.8007	1.399	Informative	INHERITED FROM: With NAD(+) or NADP(+) as acceptor || Glutamate dehydrogenase (NAD(P)(+)) || Glutamate dehydrogenase (NADP(+))
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	1.787	Highly Informative	DIRECT
Enzyme Commission (EC)	Shikimate dehydrogenase	0	1.963	Highly Informative	DIRECT
Enzyme Commission (EC)	Shikimate kinase	0.000000000002854	1.963	Highly Informative	DIRECT
Enzyme Commission (EC)	3-dehydroquinate dehydratase	0.00000000002371	1.896	Highly Informative	DIRECT
Enzyme Commission (EC)	3-dehydroquinate synthase	0.0000000008161	1.963	Highly Informative	DIRECT
Enzyme Commission (EC)	3-phosphoshikimate 1-carboxyvinyltransferase	0.00000001223	1.963	Highly Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0	0.2371	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0	0.3869	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of higher mental function	0	0.8092	Moderately Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	growth variant	0	0.3438	--	DIRECT
Worm Phenotype (WP)	developmental timing variant	0	0.4548	--	DIRECT
Worm Phenotype (WP)	general pace of development variant	0	0.4786	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	retarded heterochronic variations	0	0.4548	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || retarded heterochronic variations || reproductive system physiology variant || organism homeostasis metabolism variant || lethal || organism physiology variant || slow growth || life span variant || development variant || developmental timing variant || hermaphrodite sterile || growth variant || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || general pace of development variant || fertility variant || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	slow growth	0	0.4945	Least Informative	DIRECT
Worm Phenotype (WP)	life span variant	0	1.321	Informative	DIRECT

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	competitive fitness	0	0.1116	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1096	--	DIRECT

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.06546	--	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	cell	0	0.4069	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: cell
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: cell

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: anatomical group || multicellular anatomical structure || tissue
Xenopus ANatomical entity (XAN)	tissue	0	0.4672	Least Informative	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || shoot system
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: shoot system
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.1648	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: flowering stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: reproductive shoot system development stage || flowering stage

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Shikimate dehydrogenase	0	2.452	--	DIRECT
Enzyme Commission (EC)	Malate dehydrogenase (oxaloacetate-decarboxylating)	0	2.929	--	DIRECT
Enzyme Commission (EC)	Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+))	0	2.753	--	DIRECT
Enzyme Commission (EC)	Glutamyl-tRNA reductase	0	2.753	--	DIRECT
Enzyme Commission (EC)	Methylenetetrahydrofolate dehydrogenase (NADP(+))	0	2.929	--	DIRECT
Enzyme Commission (EC)	Methenyltetrahydrofolate cyclohydrolase	0	2.929	--	DIRECT
Enzyme Commission (EC)	Shikimate kinase	0.0000000000007342	2.452	--	DIRECT
Enzyme Commission (EC)	3-dehydroquinate dehydratase	0.000000000003814	2.385	--	DIRECT
Enzyme Commission (EC)	Quinate/shikimate dehydrogenase	0.00000000002047	2.929	--	DIRECT
Enzyme Commission (EC)	3-dehydroquinate synthase	0.0000000002179	2.452	--	DIRECT
Enzyme Commission (EC)	Malolactic enzyme	0.000000001799	2.929	--	DIRECT
Enzyme Commission (EC)	3-phosphoshikimate 1-carboxyvinyltransferase	0.000000002935	2.452	--	DIRECT
Enzyme Commission (EC)	Glutamate dehydrogenase (NAD(P)(+))	0.000001582	2.929	--	DIRECT
Enzyme Commission (EC)	Malate dehydrogenase (decarboxylating)	0.000003038	2.929	--	DIRECT
Enzyme Commission (EC)	Formate--tetrahydrofolate ligase	0.000004316	2.753	--	DIRECT
Enzyme Commission (EC)	Glutamate dehydrogenase (NADP(+))	0.00001028	2.929	--	DIRECT
Enzyme Commission (EC)	Quinate dehydrogenase	0.0001685	2.929	--	DIRECT
Enzyme Commission (EC)	Acting on the CH-OH group of donors	0.0008905	1.372	--	DIRECT
Enzyme Commission (EC)	Acting on the CH-NH(2) group of donors	0.2646	1.798	--	INHERITED FROM: Glutamate dehydrogenase (NADP(+)) || With NAD(+) or NADP(+) as acceptor || Glutamate dehydrogenase (NAD(P)(+))
Enzyme Commission (EC)	Transferring alkyl or aryl groups, other than methyl groups	1	1.567	--	INHERITED FROM: 3-phosphoshikimate 1-carboxyvinyltransferase
Enzyme Commission (EC)	Transferring phosphorus-containing groups	1	0.7021	--	INHERITED FROM: Shikimate kinase
Enzyme Commission (EC)	Carbon-carbon lyases	1	1.305	--	INHERITED FROM: Malolactic enzyme
Enzyme Commission (EC)	Carbon-oxygen lyases	1	1.208	--	INHERITED FROM: 3-dehydroquinate synthase || 3-dehydroquinate dehydratase
Enzyme Commission (EC)	Other carbon--nitrogen ligases	1	1.738	--	INHERITED FROM: Formate--tetrahydrofolate ligase
Enzyme Commission (EC)	Oxidoreductases	0	0.7328	Least Informative	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.4043	Least Informative	DIRECT
Enzyme Commission (EC)	Transferases	1	0.3972	Least Informative	INHERITED FROM: Shikimate kinase || 3-phosphoshikimate 1-carboxyvinyltransferase
Enzyme Commission (EC)	Acting on carbon-nitrogen bonds, other than peptide bonds	0	1.213	Moderately Informative	DIRECT
Enzyme Commission (EC)	Phosphotransferases with an alcohol group as acceptor	1	1.238	Moderately Informative	INHERITED FROM: Shikimate kinase
Enzyme Commission (EC)	Lyases	1	0.8775	Moderately Informative	INHERITED FROM: 3-dehydroquinate synthase || 3-dehydroquinate dehydratase || Malolactic enzyme
Enzyme Commission (EC)	Ligases	1	1.14	Moderately Informative	INHERITED FROM: Formate--tetrahydrofolate ligase
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	1.437	Informative	DIRECT
Enzyme Commission (EC)	Acting on the aldehyde or oxo group of donors	0	1.65	Informative	DIRECT
Enzyme Commission (EC)	Acting on the CH-NH group of donors	0	1.686	Informative	DIRECT
Enzyme Commission (EC)	Transferring alkyl or aryl groups, other than methyl groups	1	1.558	Informative	INHERITED FROM: 3-phosphoshikimate 1-carboxyvinyltransferase
Enzyme Commission (EC)	Carboxy-lyases	1	1.474	Informative	INHERITED FROM: Malolactic enzyme
Enzyme Commission (EC)	Hydro-lyases	1	1.385	Informative	INHERITED FROM: 3-dehydroquinate dehydratase
Enzyme Commission (EC)	Forming carbon-nitrogen bonds	1	1.338	Informative	INHERITED FROM: Formate--tetrahydrofolate ligase
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	2.054	Highly Informative	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	2.188	Highly Informative	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	1.907	Highly Informative	DIRECT
Enzyme Commission (EC)	In cyclic amidines	0	1.887	Highly Informative	DIRECT
Enzyme Commission (EC)	Acting on phosphates	0.02837	2.026	Highly Informative	INHERITED FROM: 3-dehydroquinate synthase

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