Tetrahydrofolate dehydrogenase/cyclohydrolase family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: Aminoacid dehydrogenase-like, N-terminal domain [ 53222]
• Superfamily: Aminoacid dehydrogenase-like, N-terminal domain [ 53223] (5)
• Family: Tetrahydrofolate dehydrogenase/cyclohydrolase [ 53235]

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Family statistics

	Genomes (1,770)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	2,145	13,445	4
Proteins	2,145	13,445	4

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Methylenetetrahydrofolate dehydrogenase (NADP(+))	0	2.44	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.01852	--	DIRECT
Enzyme Commission (EC)	Methenyltetrahydrofolate cyclohydrolase	0	2.44	--	DIRECT
Enzyme Commission (EC)	Acting on the CH-NH group of donors	0	1.279	--	DIRECT
Enzyme Commission (EC)	Formate--tetrahydrofolate ligase	0.00000000009436	2.264	--	DIRECT
Enzyme Commission (EC)	Oxidoreductases	0	0.3212	Least Informative	DIRECT
Enzyme Commission (EC)	Ligases	1	0.7455	Least Informative	INHERITED FROM: Formate--tetrahydrofolate ligase
Enzyme Commission (EC)	Acting on carbon-nitrogen bonds, other than peptid	0	0.8435	Moderately Informative	DIRECT
Enzyme Commission (EC)	Forming carbon-nitrogen bonds	1	0.993	Moderately Informative	INHERITED FROM: Formate--tetrahydrofolate ligase
Enzyme Commission (EC)	In cyclic amidines	0	1.462	Informative	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	1.511	Informative	DIRECT
Enzyme Commission (EC)	Other carbon--nitrogen ligases	0.2863	1.462	Informative	INHERITED FROM: Formate--tetrahydrofolate ligase

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	decreased embryo size	0.0003312	1.7	--	DIRECT
Mammalian Phenotype (MP)	abnormal embryo size	0.0005237	1.562	--	DIRECT
Mammalian Phenotype (MP)	abnormal prenatal growth/weight/body size	0.00235	1.348	--	INHERITED FROM: abnormal prenatal body size || abnormal embryo size || decreased embryo size
Mammalian Phenotype (MP)	embryo phenotype	0.008842	0.8708	--	INHERITED FROM: abnormal embryo size || decreased embryo size
Mammalian Phenotype (MP)	growth/size/body region phenotype	0.1009	0.6254	Least Informative	INHERITED FROM: abnormal embryo size || abnormal prenatal body size || decreased embryo size
Mammalian Phenotype (MP)	abnormal embryo morphology	0.004138	1.112	Moderately Informative	INHERITED FROM: decreased embryo size || abnormal embryo size
Mammalian Phenotype (MP)	abnormal prenatal body size	0.0009308	1.399	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal embryonic growth/weight/body size	0.001401	1.489	Informative	INHERITED FROM: decreased embryo size || abnormal embryo size

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	competitive fitness	0	0.1116	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1096	--	DIRECT
Yeast Phenotype (YP)	metabolism and growth	0	0.5867	Least Informative	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	guard cell	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	stomatal complex	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	epidermal cell	0	0.2152	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2046	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2224	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1621	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.227	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || guard cell || shoot system || portion of plant tissue || stomatal complex || epidermis || epidermal cell || shoot epidermal cell || plant cell || shoot epidermis
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: guard cell || shoot epidermal cell || stomatal complex || shoot system || shoot epidermis

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Methylenetetrahydrofolate dehydrogenase (NADP(+))	0	2.929	--	DIRECT
Enzyme Commission (EC)	Methenyltetrahydrofolate cyclohydrolase	0	2.929	--	DIRECT
Enzyme Commission (EC)	Formate--tetrahydrofolate ligase	0.00000000003324	2.753	--	DIRECT
Enzyme Commission (EC)	Other carbon--nitrogen ligases	0.4595	1.738	--	INHERITED FROM: Formate--tetrahydrofolate ligase
Enzyme Commission (EC)	Oxidoreductases	0	0.7328	Least Informative	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.4043	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on carbon-nitrogen bonds, other than peptide bonds	0	1.213	Moderately Informative	DIRECT
Enzyme Commission (EC)	Ligases	1	1.14	Moderately Informative	INHERITED FROM: Formate--tetrahydrofolate ligase
Enzyme Commission (EC)	Acting on the CH-NH group of donors	0	1.686	Informative	DIRECT
Enzyme Commission (EC)	Forming carbon-nitrogen bonds	1	1.338	Informative	INHERITED FROM: Formate--tetrahydrofolate ligase
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	1.907	Highly Informative	DIRECT
Enzyme Commission (EC)	In cyclic amidines	0	1.887	Highly Informative	DIRECT

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