PurM C-terminal domain-like family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a+b) [ 53931] (376)
• Fold: PurM C-terminal domain-like [ 56041]
• Superfamily: PurM C-terminal domain-like [ 56042]
• Family: PurM C-terminal domain-like [ 56043] (6)

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Family statistics

	Genomes (2,847)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	7,624	54,172	16
Proteins	6,483	47,284	11

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Cyclo-ligases	0	1.838	--	DIRECT
Enzyme Commission (EC)	Thiamine-phosphate kinase	0	2.44	--	DIRECT
Enzyme Commission (EC)	Selenide, water dikinase	0	2.44	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorous-containing groups	0.8724	0.2728	--	INHERITED FROM: Selenide, water dikinase || Phosphotransferases with paired acceptors || Thiamine-phosphate kinase
Enzyme Commission (EC)	Transferases	1	0	--	INHERITED FROM: Thiamine-phosphate kinase || Phosphotransferases with paired acceptors || Phosphoribosylglycinamide formyltransferase || Selenide, water dikinase
Enzyme Commission (EC)	Ligases	0	0.7455	Least Informative	DIRECT
Enzyme Commission (EC)	Transferring one-carbon groups	1	0.72	Least Informative	INHERITED FROM: Phosphoribosylglycinamide formyltransferase
Enzyme Commission (EC)	Forming carbon-nitrogen bonds	0	0.993	Moderately Informative	DIRECT
Enzyme Commission (EC)	Carbon--nitrogen ligases with glutamine as amido-N	0	1.595	Informative	DIRECT
Enzyme Commission (EC)	Other carbon--nitrogen ligases	1	1.462	Informative	INHERITED FROM: Phosphoribosylamine--glycine ligase
Enzyme Commission (EC)	Phosphotransferases with a phosphate group as acce	0.03058	1.537	Informative	INHERITED FROM: Thiamine-phosphate kinase
Enzyme Commission (EC)	Hydroxymethyl-, formyl- and related transferases	1	1.537	Informative	INHERITED FROM: Phosphoribosylglycinamide formyltransferase
Enzyme Commission (EC)	Phosphoribosylformylglycinamidine cyclo-ligase	0	1.963	Highly Informative	DIRECT
Enzyme Commission (EC)	Phosphoribosylformylglycinamidine synthase	0	2.139	Highly Informative	DIRECT
Enzyme Commission (EC)	Phosphotransferases with paired acceptors	0	2.042	Highly Informative	DIRECT
Enzyme Commission (EC)	Phosphoribosylglycinamide formyltransferase	0.0000000000007916	1.963	Highly Informative	DIRECT
Enzyme Commission (EC)	Phosphoribosylamine--glycine ligase	0.000000000002724	1.963	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	growth variant	0	0.3438	--	DIRECT
Worm Phenotype (WP)	developmental timing variant	0	0.4548	--	DIRECT
Worm Phenotype (WP)	general pace of development variant	0	0.4786	--	DIRECT
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	retarded heterochronic variations	0	0.4548	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	larval development variant	0	0.4322	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	developmental growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	larval growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	sterile progeny	0	0.6547	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || developmental growth variant || retarded heterochronic variations || larval lethal || reproductive system physiology variant || organism homeostasis metabolism variant || lethal || larval development variant || sterile progeny || organism physiology variant || progeny variant || slow growth || development variant || developmental timing variant || hermaphrodite sterile || growth variant || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || larval growth variant || general pace of development variant || fertility variant || postembryonic development variant || larval arrest || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile || sterile progeny
Worm Phenotype (WP)	slow growth	0	0.4945	Least Informative	DIRECT
Worm Phenotype (WP)	larval lethal	0	0.5727	Least Informative	DIRECT
Worm Phenotype (WP)	larval arrest	0	0.4991	Least Informative	DIRECT
Worm Phenotype (WP)	progeny variant	0	0.6514	Least Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Thiamine-phosphate kinase	0	2.929	--	DIRECT
Enzyme Commission (EC)	Phosphotransferases with paired acceptors	0	2.531	--	DIRECT
Enzyme Commission (EC)	Selenide, water dikinase	0	2.929	--	DIRECT
Enzyme Commission (EC)	Phosphoribosylformylglycinamidine cyclo-ligase	0	2.452	--	DIRECT
Enzyme Commission (EC)	Phosphoribosylformylglycinamidine synthase	0	2.531	--	DIRECT
Enzyme Commission (EC)	Phosphoribosylglycinamide formyltransferase	0.0000000000006016	2.452	--	DIRECT
Enzyme Commission (EC)	Phosphoribosylamine--glycine ligase	0.0000000000008498	2.452	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0.7383	0.7021	--	INHERITED FROM: Thiamine-phosphate kinase || Phosphotransferases with paired acceptors || Selenide, water dikinase
Enzyme Commission (EC)	Other carbon--nitrogen ligases	1	1.738	--	INHERITED FROM: Phosphoribosylamine--glycine ligase
Enzyme Commission (EC)	Transferases	1	0.3972	Least Informative	INHERITED FROM: Thiamine-phosphate kinase || Selenide, water dikinase || Phosphotransferases with paired acceptors || Phosphoribosylglycinamide formyltransferase
Enzyme Commission (EC)	Ligases	0	1.14	Moderately Informative	DIRECT
Enzyme Commission (EC)	Transferring one-carbon groups	1	1.161	Moderately Informative	INHERITED FROM: Phosphoribosylglycinamide formyltransferase
Enzyme Commission (EC)	Forming carbon-nitrogen bonds	0	1.338	Informative	DIRECT
Enzyme Commission (EC)	Cyclo-ligases	0	2.23	Highly Informative	DIRECT
Enzyme Commission (EC)	Carbon--nitrogen ligases with glutamine as amido-N-donor	0	1.999	Highly Informative	DIRECT
Enzyme Commission (EC)	Phosphotransferases with a phosphate group as acceptor	0.007236	1.951	Highly Informative	INHERITED FROM: Thiamine-phosphate kinase
Enzyme Commission (EC)	Hydroxymethyl-, formyl- and related transferases	0.9917	1.999	Highly Informative	INHERITED FROM: Phosphoribosylglycinamide formyltransferase

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