CTD Chemicals (CC): Macrocyclic Compounds 

Root: CC Hierarchy (CTD chemicals from Comparative Toxicogenomics Database)

Shortest distance to current term (+ for parents, - for children)	CC term [CC ID] <#Children>	#Domains (Superfamily|Family)	#Supra-domain (Single|Duplex|Triple)
+ + 2:	Chemicals [MESH:D] <13>
+ 1:	Polycyclic Compounds [MESH:D011083] <191>	(419|579)	(431|390|204)
0:	Macrocyclic Compounds [MESH:D047028] <111>	(186|253)	(192|153|75)
- 1:	Peptides, Cyclic [MESH:D010456] <1610>	(59|95)	(61|51|20)
- 1:	Polyketides [MESH:D061065] <172>	(32|34)	(33|18|7)
- 1:	Ethers, Cyclic [MESH:D004988] <121>	(29|30)	(32|15|4)
- 1:	Trichothecenes [MESH:D014255] <101>	(11|16)	(12|4|0)
- 1:	Calixarenes [MESH:D047250] <100>	(0|0)	(0|0|0)
- 1:	Lactams, Macrocyclic [MESH:D047029] <76>	(10|15)	(14|9|3)
- 1:	Cyclodextrins [MESH:D003505] <61>	(2|2)	(2|0|0)
- 1:	Cycloparaffins [MESH:D003516] <36>	(113|125)	(120|74|36)
- 1:	Tetrapyrroles [MESH:D045725] <11>	(23|25)	(23|10|2)
- 1:	Crown Compounds [MESH:D047248] <3>	(0|0)	(0|0|0)
- 1:	(15)pyN5 [MESH:C575437]	(0|0)	(0|0|0)
- 1:	(3R)-methylazacyclodecane [MESH:C000610618]	(0|0)	(0|0|0)
- 1:	(R,Z)-5-muscenone [MESH:C518850]	(0|0)	(0|0|0)
- 1:	(RSSR)-1,9-dibenzyl-3,7,11,15-tetramesityl-1,9-diaza-3,7,11,15-tetraphosphacyclohexadecane [MESH:C500566]	(0|0)	(0|0|0)
- 1:	1,4,7,10-tetramethyl-1,4,7,10-tetraazacyclododecane [MESH:C000609946]	(0|0)	(0|0|0)
- 1:	1,4,8,11-tetramethyl-1,4,8,11-tetraazacyclotetradecane [MESH:C000609945]	(0|0)	(0|0|0)
- 1:	10'-bis(acetamido)ethane-bis(1,4,7-tri(carboxymethane)-1,4,7,10-tetraazacyclododecane) [MESH:C559336]	(0|0)	(0|0|0)
- 1:	18-diazo-1,4,7,10,13,16-hexaoxacyclononadeca-17,19-dione [MESH:C511476]	(0|0)	(0|0|0)
- 1:	2,9-dipropyl-3,10-dimethyl-1,4,8,11-tetraaza-5,7-12,14-dibenzocyclotetradeca-1,3,8,10-tetraene [MESH:C502509]	(0|0)	(0|0|0)
- 1:	22-hydroxyhaliclonacyclamine B [MESH:C545778]	(0|0)	(0|0|0)
- 1:	3-methylcyclopentadecenone [MESH:C571558]	(0|0)	(0|0|0)
- 1:	4-cyclopentadecen-1-one [MESH:C571567]	(0|0)	(0|0|0)
- 1:	4-methylcyclopentadecanone [MESH:C000589480]	(0|0)	(0|0|0)
- 1:	4-octasulfophenylpyrazinoporphyrazine [MESH:C500569]	(0|0)	(0|0|0)
- 1:	5-cyclohexadecen-1-one [MESH:C571564]	(0|0)	(0|0|0)
- 1:	7-cycloparaphenylene [MESH:C000590613]	(0|0)	(0|0|0)
- 1:	8-cycloparaphenylene [MESH:C000590614]	(0|0)	(0|0|0)
- 1:	9'-epi-3beta,3'beta-dimethylxestospongin C [MESH:C558257]	(0|0)	(0|0|0)
- 1:	ABT-450 [MESH:C585405]	(0|0)	(0|0|0)
- 1:	AZD5991 [MESH:C000629704]	(0|0)	(0|0|0)
- 1:	BILN 2061 [MESH:C479555]	(0|0)	(0|0|0)
- 1:	Cyclams [MESH:D000080027]	(0|0)	(0|0|0)
- 1:	GP205 compound [MESH:C000604458]	(0|0)	(0|0|0)
- 1:	IDX320 [MESH:C574703]	(0|0)	(0|0|0)
- 1:	JNJ-26483327 [MESH:C553025]	(0|0)	(0|0|0)
- 1:	Jolkinol D [MESH:C000622152]	(0|0)	(0|0|0)
- 1:	MK-6325 [MESH:C000600429]	(0|0)	(0|0|0)
- 1:	N,N'-Bis((6-carboxy-2-pyridyl)methyl)-1,7-diaza-12-crown-4 [MESH:C533505]	(0|0)	(0|0|0)
- 1:	PF 1163A [MESH:C405057]	(0|0)	(0|0|0)
- 1:	PF 1163B [MESH:C405058]	(0|0)	(0|0|0)
- 1:	ST104P compound [MESH:C000598177]	(0|0)	(0|0|0)
- 1:	Viekira Pak [MESH:C000607373]	(0|0)	(0|0|0)
- 1:	ambrettolide [MESH:C583632]	(0|0)	(0|0|0)
- 1:	amythiamicin A [MESH:C088498]	(0|0)	(0|0|0)
- 1:	amythiamicin B [MESH:C088499]	(0|0)	(0|0|0)
- 1:	amythiamicin C [MESH:C088500]	(0|0)	(0|0|0)
- 1:	amythiamicin D [MESH:C088501]	(0|0)	(0|0|0)
- 1:	arenosclerin A [MESH:C414423]	(0|0)	(0|0|0)
- 1:	arenosclerin B [MESH:C414424]	(0|0)	(0|0|0)
- 1:	arenosclerin C [MESH:C414425]	(0|0)	(0|0|0)
- 1:	aspercyclide A [MESH:C542833]	(0|0)	(0|0|0)
- 1:	aspercyclide B [MESH:C542834]	(0|0)	(0|0|0)
- 1:	aspercyclide C [MESH:C519042]	(0|0)	(0|0|0)
- 1:	bambus(6)uril [MESH:C569684]	(0|0)	(0|0|0)
- 1:	callyazepin [MESH:C000610617]	(0|0)	(0|0|0)
- 1:	carboxylatopillar(6)arene [MESH:C000626710]	(0|0)	(0|0|0)
- 1:	carceplex [MESH:C506097]	(0|0)	(0|0|0)
- 1:	chirobiotic T [MESH:C000597575]	(0|0)	(0|0|0)
- 1:	cucurbituril [MESH:C513894]	(0|0)	(0|0|0)
- 1:	cyclo(-6)-glucopyranosyl-1-4-glucopyranosyl-1-6-glucopyranosyl-1-4-glucopyranosyl-(1-) [MESH:C504607]	(0|0)	(0|0|0)
- 1:	cyclo(-6)-glucpyranosyl-1-3-glucopyranosyl-1-6-glucopyranosyl-1-3-(glucopyranosyl-1-6)-glucopyranosy [MESH:C504006]	(0|0)	(0|0|0)
- 1:	cyclo(-6)-glucpyranosyl-1-3-glucopyranosyl-1-6-glucopyranosyl-1-3-glucopyranosyl-1-4-glucopyranosyl- [MESH:C504005]	(0|0)	(0|0|0)
- 1:	cycloheptadeca-9-en-1-one [MESH:C571563]	(0|0)	(0|0|0)
- 1:	cyclohexadec-8-en-1-one [MESH:C571566]	(0|0)	(0|0|0)
- 1:	cyclotrehalan [MESH:C542733]	(0|0)	(0|0|0)
- 1:	decamethylpressocucurbit(5)uril [MESH:C000600075]	(0|0)	(0|0|0)
- 1:	dracophane [MESH:C473715]	(0|0)	(0|0|0)
- 1:	floresolide B [MESH:C519225]	(0|0)	(0|0|0)
- 1:	gamitrinib-triphenylphosphonium [MESH:C000626826]	(0|0)	(0|0|0)
- 1:	gymnorrhizol [MESH:C520145]	(0|0)	(0|0|0)
- 1:	haliclonacyclamine A [MESH:C114409]	(0|0)	(0|0|0)
- 1:	haliclonacyclamine B [MESH:C114410]	(0|0)	(0|0|0)
- 1:	haliclonacyclamine C [MESH:C549558]	(0|0)	(0|0|0)
- 1:	haliclonacyclamine E [MESH:C414422]	(0|0)	(0|0|0)
- 1:	haliclonin A [MESH:C540232]	(0|0)	(0|0|0)
- 1:	incednam [MESH:C555192]	(0|0)	(0|0|0)
- 1:	iron-3,3,6,6,9,9-hexamethyl-3,4,8,9-tetrahydro-1H-1,4,8,11-benzotetraazacyclotridecine-2,5,7,10(6H,1 [MESH:C517362]	(0|0)	(0|0|0)
- 1:	isoplagiochin A [MESH:C538707]	(0|0)	(0|0|0)
- 1:	isoplagiochin B [MESH:C538708]	(0|0)	(0|0|0)
- 1:	lepimectin A3 [MESH:C000613604]	(0|0)	(0|0|0)
- 1:	lepimectin A4 [MESH:C000613605]	(0|0)	(0|0|0)
- 1:	maltepolide [MESH:C583984]	(0|0)	(0|0|0)
- 1:	merocyclophane C [MESH:C000621337]	(0|0)	(0|0|0)
- 1:	merocyclophane D [MESH:C000621338]	(0|0)	(0|0|0)
- 1:	metacridamide A [MESH:C571467]	(0|0)	(0|0|0)
- 1:	metacridamide B [MESH:C571468]	(0|0)	(0|0|0)
- 1:	nannocystin A [MESH:C000607748]	(0|0)	(0|0|0)
- 1:	octaamine 1 [MESH:C513577]	(0|0)	(0|0|0)
- 1:	oxacyclododecindione [MESH:C532274]	(0|0)	(0|0|0)
- 1:	oxacyclohexadec-12(13)-en-2-one [MESH:C571568]	(0|0)	(0|0|0)
- 1:	paecilomycin B [MESH:C000601938]	(0|0)	(0|0|0)
- 1:	phelligridimer A [MESH:C512234]	(0|0)	(0|0|0)
- 1:	radanamycin [MESH:C511138]	(0|0)	(0|0|0)
- 1:	sofosbuvir, velpatasvir and voxilaprevir [MESH:C000654129]	(0|0)	(0|0|0)
- 1:	sorangiolide B [MESH:C521909]	(0|0)	(0|0|0)
- 1:	symbiodinolide [MESH:C544635]	(0|0)	(0|0|0)
- 1:	syphonoside [MESH:C522937]	(0|0)	(0|0|0)
- 1:	tenvermectin [MESH:C000628512]	(0|0)	(0|0|0)
- 1:	tetraaza(6.1.6.1)paracyclophane [MESH:C525610]	(0|0)	(0|0|0)
- 1:	tetralactam macrocycle [MESH:C535036]	(0|0)	(0|0|0)
- 1:	tetramethylcucurbit(6)uril [MESH:C520273]	(0|0)	(0|0|0)
- 1:	tonantzitlolone [MESH:C510266]	(0|0)	(0|0|0)
- 1:	trans-3,3'-dihydroxy-1,5,1',5'-tetrathiacyclodecane [MESH:C548532]	(0|0)	(0|0|0)
- 1:	trianglimine [MESH:C511280]	(0|0)	(0|0|0)
- 1:	ulimorelin [MESH:C528884]	(0|0)	(0|0|0)
- 1:	unantimycin A [MESH:C000626958]	(0|0)	(0|0|0)
- 1:	voxilaprevir [MESH:C000619503]	(0|0)	(0|0|0)
- 1:	xestospongin A [MESH:C108644]	(0|0)	(0|0|0)
- 1:	xestospongin B [MESH:C078549]	(0|0)	(0|0|0)
- 1:	xestospongin C [MESH:C511704]	(0|0)	(0|0|0)
- 1:	xestospongin D [MESH:C108642]	(0|0)	(0|0|0)

Superfamily

Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
ValRS/IleRS/LeuRS editing domain	0	DIRECT
occludin/ELL-like	0	DIRECT
Serum albumin-like	0	DIRECT
PRC-barrel domain	0	DIRECT
BAG domain	0	DIRECT
Nuclear receptor coactivator interlocking domain	0	DIRECT
Inhibitor of apoptosis (IAP) repeat	0	DIRECT
GINS helical bundle-like	0	DIRECT
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	0	DIRECT
Mediator hinge subcomplex-like	0	DIRECT
SIS domain	0	DIRECT
Di-copper centre-containing domain	0	DIRECT
EB1 dimerisation domain-like	0	DIRECT
Inosine monophosphate dehydrogenase (IMPDH)	0	DIRECT
beta-lactamase/transpeptidase-like	0	DIRECT
Alpha-L RNA-binding motif	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
Protein prenylyltransferase	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
Nucleotide-binding domain	0	DIRECT
Nitric oxide (NO) synthase oxygenase domain	0	DIRECT
PAH2 domain	0	DIRECT
Formyltransferase	0	DIRECT
FMN-linked oxidoreductases	0	DIRECT
Phosphoglucomutase, C-terminal domain	0	DIRECT
EPT/RTPC-like	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
PHM/PNGase F	0	DIRECT
P-domain of calnexin/calreticulin	0	DIRECT
AhpD-like	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
SMAD MH1 domain	0	DIRECT
Nicotinate/Quinolinate PRTase C-terminal domain-like	0	DIRECT
ISP domain	0	DIRECT
alpha-ketoacid dehydrogenase kinase, N-terminal domain	0	DIRECT
Rudiment single hybrid motif	0	DIRECT
Nop domain	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
Phosphoenolpyruvate/pyruvate domain	0	DIRECT
14-3-3 protein	0	DIRECT
FMT C-terminal domain-like	0	DIRECT
Alanine racemase C-terminal domain-like	0	DIRECT
PLP-binding barrel	0	DIRECT
ATP-dependent DNA ligase DNA-binding domain	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
CAPPD, an extracellular domain of amyloid beta A4 protein	0	DIRECT
Integrin beta tail domain	0	DIRECT
PK beta-barrel domain-like	0	DIRECT
4Fe-4S ferredoxins	0	DIRECT
A heparin-binding domain	0	DIRECT
Fibrinogen coiled-coil and central regions	0	DIRECT
Apolipoprotein A-I	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	DIRECT
p53 tetramerization domain	0	DIRECT
Amyloid beta a4 protein copper binding domain (domain 2)	0	DIRECT
PriA/YqbF domain	0	DIRECT
Chicken cartilage matrix protein	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
Aminoacid dehydrogenase-like, N-terminal domain	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
Amine oxidase N-terminal region	0	DIRECT
STAT	0	DIRECT
Amine oxidase catalytic domain	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Seven-hairpin glycosidases	0	DIRECT
Single hybrid motif	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
S15/NS1 RNA-binding domain	0	DIRECT
Homocysteine S-methyltransferase	0	DIRECT
Activating enzymes of the ubiquitin-like proteins	0	DIRECT
Ribosomal protein L16p/L10e	0	DIRECT
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain	0	DIRECT
FAD-linked oxidoreductase	0	DIRECT
Transcription factor STAT-4 N-domain	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
Cytochrome P450	0.000001187	DIRECT
NAD(P)-binding Rossmann-fold domains	0.0000191	DIRECT
Leucine zipper domain	0.0001679	DIRECT
Thioredoxin-like	0.0002065	DIRECT
Nuclear receptor ligand-binding domain	0.0002114	DIRECT
TNF receptor-like	0.002821	INHERITED FROM: Nystatin || Epoxy Compounds || Paclitaxel || 4-(3-(1-adamantyl)-4-hydroxyphenyl)-3-chlorocinnamic acid || Cyclohexanes || Cyclohexanols || Menthol || motexafin gadolinium || Cyclohexane Monoterpenes
Caspase-like	0.00464	INHERITED FROM: deoxynivalenol || diepoxybutane || bafilomycin A1 || Trichothecenes || cypermethrin || Dactinomycin || Acitretin || Sesquiterpenes, Guaiane || Cyclohexanones || Amantadine || Ethers, Cyclic || surfactin peptide || Epoxy Compounds || Depsipeptides || dehydroxymethylepoxyquinomicin || Cyclohexanecarboxylic Acids || Fenretinide || Cycloheptanes || Pyrethrins || Polyketides || zinc protoporphyrin || Cyclohexanes || CD 437 || Cyclodecanes || Cyclohexanols || Menthol || Macrolides || methyl 5-chloro-4,5-didehydrojasmonate || Taxoids || Ketamine || apicidin || manganese(III)-tetrakis(4-benzoic acid)porphyrin || NSC 680410 || Cyclohexane Monoterpenes || Xanthophylls || Cyclopentanes || cobaltiprotoporphyrin
ALDH-like	0.009221	INHERITED FROM: apocarotenal || Retinaldehyde
Calpain large subunit, middle domain (domain III)	0.01067	INHERITED FROM: glycidamide || Epoxy Compounds || Menthol || Cyclohexane Monoterpenes
Integrin domains	0.01259	INHERITED FROM: Cyclohexenes || Retinoids
Aldolase	0.01604	INHERITED FROM: Peptides, Cyclic || Cyclosporins
Thyroglobulin type-1 domain	0.01636	INHERITED FROM: Tretinoin || glycidamide || Cyclohexenes || Vitamin A || Paclitaxel || Retinoids || Menthol
Protein kinase-like (PK-like)	0.01955	INHERITED FROM: aucubin || 4-acetylantroquinonol B || beta-Cyclodextrins || cyanoginosin LR || Microcystins || beta-ionone || Iridoid Glycosides || Maytansine || Polyketides || Cyclodecanes || Lycopene || 3-O-caffeoyl-1-methylquinic acid || Macrolides || Lactams, Macrocyclic || Cyclodextrins || NSC 680410 || tanespimycin
Glucocorticoid receptor-like (DNA-binding domain)	0.0202	INHERITED FROM: Alitretinoin || 1,1-bis(4-hydroxyphenyl)cyclohexane || Ciclopirox || diisononyl 1,2-cyclohexanedicarboxylic acid || 9-cis-retinal || phenothrin || beta Carotene || Cyclohexanecarboxylic Acids || Fenretinide || cyhalothrin || Permethrin || Pyrethrins || 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid || fenvalerate || SR 11237 || 2,2-bis(4-glycidyloxyphenyl)propane || Bexarotene || 4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid || Cyclopentane Monoterpenes || 4-hydroxyretinoic acid || Valinomycin || Retinaldehyde || Cyclopentanes
A DNA-binding domain in eukaryotic transcription factors	0.02348	INHERITED FROM: deoxynivalenol || Tretinoin || Trichothecenes || Tetrapyrroles || Epoxy Compounds || Vitamin A || Hemin
Cyclin-like	0.03046	INHERITED FROM: Ethers, Cyclic || Paclitaxel || Polyketides || Cyclodecanes || 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid || apicidin
Heat shock protein 70kD (HSP70), C-terminal subdomain	0.0354	INHERITED FROM: Ivermectin || Tetrapyrroles || Thiostrepton || aurin || Cyclohexanecarboxylic Acids || Polyketides || Porphyrins
Ribosomal protein S5 domain 2-like	0.03573	INHERITED FROM: CD 437
Bcl-2 inhibitors of programmed cell death	0.03767	INHERITED FROM: Thapsigargin || Rifampin || deoxynivalenol || diepoxybutane || IDN 5109 || Sirolimus || Trichothecenes || Dactinomycin || Ethers, Cyclic || Docetaxel || Depsipeptides || Thiostrepton || Paclitaxel || destruxin B || beta Carotene || Fenretinide || Pyrethrins || Polyketides || Cyclohexanes || Cyclohexanols || Menthol || Cycloparaffins || 2,2-bis(4-glycidyloxyphenyl)propane || pramanicin || Lutein || tanespimycin || Cyclohexane Monoterpenes || Xanthophylls || Epothilones
GroES-like	0.04313	INHERITED FROM: apocarotenal
Nucleic acid-binding proteins	0.04905	INHERITED FROM: Thapsigargin || Adamantane || Sesquiterpenes, Guaiane || Quinic Acid || Cycloheptanes || CD 437 || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || beauvericin
Kringle-like	0.06189	INHERITED FROM: Dactinomycin || Tetrapyrroles || genipin || Iridoids || Porphyrins
Metallothionein	0.06442	INHERITED FROM: Sirolimus || Tetrapyrroles || Metalloporphyrins || Macrolides || motexafin gadolinium || Porphyrins
Leukotriene A4 hydrolase N-terminal domain	0.06442	INHERITED FROM: Peptides, Cyclic || Cyclosporins
GST C-terminal domain-like	0.07358	INHERITED FROM: microcystin RR || apple polyphenol extract || Microcystins || beta Carotene || apocarotenal || Okadaic Acid || Bile Pigments
vWA-like	0.08612	INHERITED FROM: Cyclodecanes
GroEL-intermediate domain like	0.08875	INHERITED FROM: Adamantane || Ivermectin || Okadaic Acid || CD 437 || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid
Mitochondrial carrier	0.09464	INHERITED FROM: Thapsigargin || Sesquiterpenes, Guaiane || Cycloheptanes || CD 437 || enniatins
FAD/NAD(P)-binding domain	0.09975	INHERITED FROM: Cyclosporins || Xanthophylls
TPR-like	0.1002	INHERITED FROM: Cyclosporins
Thiolase-like	0.1088	INHERITED FROM: Isotretinoin || Polyketides
Sm-like ribonucleoproteins	0.1126	INHERITED FROM: Adamantane || Ethers, Cyclic || Oxocins || yessotoxin || CD 437 || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid
CoA-dependent acyltransferases	0.1209	INHERITED FROM: Isotretinoin
Alkaline phosphatase-like	0.1261	INHERITED FROM: Oxocins || yessotoxin
YWTD domain	0.1319	INHERITED FROM: Peptides, Cyclic || Bile Pigments || Cyclosporins
Cyclophilin-like	0.1347	INHERITED FROM: Oxocins || yessotoxin
Nucleotidylyl transferase	0.1477	INHERITED FROM: Thapsigargin || Sesquiterpenes, Guaiane || 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol
GroEL equatorial domain-like	0.1505	INHERITED FROM: Adamantane || Ivermectin || Okadaic Acid || CD 437 || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid
GroEL apical domain-like	0.1505	INHERITED FROM: Adamantane || Ivermectin || Okadaic Acid || CD 437 || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid
Lipocalins	0.1549	INHERITED FROM: 4-oxoretinoic acid
Growth factor receptor domain	0.1576	INHERITED FROM: Paclitaxel
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0.1591	INHERITED FROM: microcystin RR || Microcystins
Prefoldin	0.16	INHERITED FROM: 4-oxoretinoic acid || Alitretinoin || beta Carotene || 4-oxoretinol || Bexarotene || ethyl-p-((E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-1-propenyl)benzoic acid
Flavoproteins	0.1624	INHERITED FROM: Tetrapyrroles || Polyketides || Porphyrins
Zn-binding ribosomal proteins	0.1624	INHERITED FROM: Adamantane || CD 437 || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid
NAD(P)-linked oxidoreductase	0.1705	INHERITED FROM: glycidamide || Ethers, Cyclic || 9-cis-retinal || cyclopentanol || cyclopentanone || Retinaldehyde
BRCT domain	0.184	INHERITED FROM: Fenretinide
Ferredoxin reductase-like, C-terminal NADP-linked domain	0.194	INHERITED FROM: Tacrolimus
Riboflavin synthase domain-like	0.194	INHERITED FROM: Tacrolimus
ClpP/crotonase	0.1948	INHERITED FROM: Isotretinoin
ABC transporter transmembrane region	0.1985	INHERITED FROM: Rifampin || Dactinomycin || Docetaxel || Rifamycins || Cyclodecanes || Lactams, Macrocyclic || Taxoids
Hemopexin-like domain	0.2147	INHERITED FROM: Tetrapyrroles || Paclitaxel || Cyclodecanes || Porphyrins || manganese(III)-tetrakis(4-benzoic acid)porphyrin || cyclo(Trp-Asp-Pro-Val-Leu) || Chlorogenic Acid || 3-caffeoyl-4-dihydrocaffeoylquinic acid
E2F-DP heterodimerization region	0.215	INHERITED FROM: Paclitaxel || Cyclohexanols || Menthol || Cyclohexane Monoterpenes
Carbon-nitrogen hydrolase	0.2281	INHERITED FROM: Isotretinoin
FnI-like domain	0.2386	INHERITED FROM: Tetrapyrroles
Tubulin C-terminal domain-like	0.2499	INHERITED FROM: Thapsigargin || Sesquiterpenes, Guaiane || 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol
DEATH domain	0.25	INHERITED FROM: Nystatin || cypermethrin || Dactinomycin || nodularin || Acitretin || Cyclohexanones || Ethers, Cyclic || Tetrapyrroles || Depsipeptides || dehydroxymethylepoxyquinomicin || beta Carotene || brevetoxin 2 || Oxocins || Fenretinide || 4-(3-(1-adamantyl)-4-hydroxyphenyl)-3-chlorocinnamic acid || Pyrethrins || Polyketides || Cyclodecanes || Cyclohexanols || Menthol || Cycloparaffins || Epichlorohydrin || Macrolides || bis(acetato)(1-adamantylamine)amminedichloroplatinum(IV) || methyl 5-chloro-4,5-didehydrojasmonate || Taxoids || Porphyrins || Cyclohexane Monoterpenes
UDP-Glycosyltransferase/glycogen phosphorylase	0.2535	INHERITED FROM: Cyclohexanecarboxylic Acids
EGF/Laminin	0.2735	INHERITED FROM: Cycloparaffins
Serpins	0.2765	INHERITED FROM: Rifampin
BTG domain-like	0.2899	INHERITED FROM: LG 100815
HD-domain/PDEase-like	0.2998	INHERITED FROM: Cyclohexanecarboxylic Acids || Cyclopropanes || Roflumilast || Cilomilast
P-loop containing nucleoside triphosphate hydrolases	0.3051	INHERITED FROM: Docetaxel
Class II aaRS and biotin synthetases	0.3398	INHERITED FROM: Thapsigargin || Sesquiterpenes, Guaiane || Cycloheptanes
p53-like transcription factors	0.344	INHERITED FROM: deoxynivalenol || Dactinomycin || Cyclohexanones || Polyketides || Macrolides || pevonedistat || Cyclopentanes
Ferritin-like	0.3634	INHERITED FROM: Paclitaxel || Cyclodecanes
LuxS/MPP-like metallohydrolase	0.3634	INHERITED FROM: Isotretinoin
MHC antigen-recognition domain	0.3659	INHERITED FROM: Erythromycin
SCOP hierarchy in SUPERFAMILY	0.3659	INHERITED FROM: Oxocins || yessotoxin
Cytochrome b5-like heme/steroid binding domain	0.3684	INHERITED FROM: Isotretinoin
(Trans)glycosidases	0.3702	INHERITED FROM: Oxocins || yessotoxin
CAD & PB1 domains	0.3785	INHERITED FROM: Cyclohexanols || Menthol || Cyclohexane Monoterpenes
PGBD-like	0.3785	INHERITED FROM: Tetrapyrroles || Paclitaxel || Cyclohexanecarboxylic Acids || Cyclodecanes || Porphyrins || manganese(III)-tetrakis(4-benzoic acid)porphyrin || cyclo(Trp-Asp-Pro-Val-Leu) || Chlorogenic Acid || 3-caffeoyl-4-dihydrocaffeoylquinic acid
Tubulin nucleotide-binding domain-like	0.3829	INHERITED FROM: Thapsigargin || Sesquiterpenes, Guaiane || 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol
Bromodomain	0.4086	INHERITED FROM: deoxynivalenol
Actin-like ATPase domain	0.4134	INHERITED FROM: Ivermectin || Thiostrepton || Hemin || aurin
TRAF domain-like	0.4301	INHERITED FROM: Cyclohexanols || Menthol || Cyclohexane Monoterpenes
Cysteine-rich domain	0.446	INHERITED FROM: Bryostatins
Toll/Interleukin receptor TIR domain	0.4727	INHERITED FROM: Ivermectin || Paclitaxel || Cyclodecanes
4-helical cytokines	0.4764	INHERITED FROM: deoxynivalenol || Clarithromycin || Trichothecenes || Dactinomycin || Alitretinoin || Ethers, Cyclic || Tetrapyrroles || Cyclohexanecarboxylic Acids || brevetoxin 2 || Oxocins || Polyketides || apocarotenal || primycin || helenalin || Cilomilast
SH2 domain	0.51	INHERITED FROM: 4-acetylantroquinonol B || Cyclohexanones
Fibronectin type III	0.5123	INHERITED FROM: Cycloparaffins
Frizzled cysteine-rich domain	0.5322	INHERITED FROM: Tretinoin || Vitamin A || Cyclohexanes
DNA/RNA polymerases	0.543	INHERITED FROM: diepoxybutane || Epoxy Compounds
Nucleoside diphosphate kinase, NDK	0.5472	INHERITED FROM: Menthol || Cyclohexane Monoterpenes
TK C-terminal domain-like	0.5777	INHERITED FROM: Isotretinoin
Cystine-knot cytokines	0.6012	INHERITED FROM: Protoporphyrins || Oxocins || Octreotide
RNA-binding domain, RBD	0.6725	INHERITED FROM: yessotoxin || pateamine A || 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol
SMAD/FHA domain	0.6781	INHERITED FROM: aucubin || Iridoid Glucosides || Iridoid Glycosides || Iridoids
BPTI-like	0.7122	INHERITED FROM: Paclitaxel || Cyclodecanes
MFS general substrate transporter	0.7299	INHERITED FROM: Rifampin || Nateglinide || Rifamycins || Lactams, Macrocyclic || Erythromycin
TNF-like	0.7315	INHERITED FROM: brevetoxin 2 || Cyclohexanols || Menthol || Cyclohexane Monoterpenes
Rhodanese/Cell cycle control phosphatase	0.7474	INHERITED FROM: Trichothecenes || glycidamide
SNF-like	0.7764	INHERITED FROM: 2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone || Cyclohexanones || Cyclohexylamines
CCCH zinc finger	0.7903	INHERITED FROM: 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol
C2 domain (Calcium/lipid-binding domain, CaLB)	0.828	INHERITED FROM: Bryostatins
Interleukin 8-like chemokines	0.8367	INHERITED FROM: Trichothecenes || beta Carotene || Polyketides || Cyclopropanes || 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol || primycin || pevonedistat || Roflumilast || Antimycin A || roflumilast N-oxide
SNARE-like	0.8561	INHERITED FROM: yessotoxin
PYP-like sensor domain (PAS domain)	0.8724	INHERITED FROM: Rifampin || Rifamycins || Lactams, Macrocyclic || Cyclopentanes
HLH, helix-loop-helix DNA-binding domain	0.9166	INHERITED FROM: Rifampin
Chaperone J-domain	0.9884	INHERITED FROM: motexafin gadolinium
Metalloproteases ("zincins"), catalytic domain	0.9975	INHERITED FROM: manganese(III)-tetrakis(4-benzoic acid)porphyrin || cyclo(Trp-Asp-Pro-Val-Leu) || 3-caffeoyl-4-dihydrocaffeoylquinic acid
Cadherin-like	1	INHERITED FROM: jasplakinolide
Neurotransmitter-gated ion-channel transmembrane pore	1	INHERITED FROM: carvone || menthone || Picrotoxin
Nicotinic receptor ligand binding domain-like	1	INHERITED FROM: carvone || menthone || Picrotoxin
Intermediate filament protein, coiled coil region	1	INHERITED FROM: Isotretinoin || 4-oxoretinoic acid || Alitretinoin || Microcystins || beta Carotene || 4-oxoretinol || ethyl-p-((E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-1-propenyl)benzoic acid
Immunoglobulin	1	INHERITED FROM: helenalin
Homeodomain-like	1	INHERITED FROM: beta Carotene || apocarotenal
Translation proteins SH3-like domain	1	INHERITED FROM: Adamantane || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid

Family

Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Protein-L-isoaspartyl O-methyltransferase	0	DIRECT
4HBT-like	0	DIRECT
Nuclear receptor coactivator interlocking domain	0	DIRECT
alpha-ketoacid dehydrogenase kinase, N-terminal domain	0	DIRECT
C5 cytosine-specific DNA methylase, DCM	0	DIRECT
Ribonuclease PH domain 1-like	0	DIRECT
Formate/glycerate dehydrogenases, substrate-binding domain	0	DIRECT
p53 tetramerization domain	0	DIRECT
Amine oxidase N-terminal region	0	DIRECT
HAT/Suf repeat	0	DIRECT
Multidomain cupredoxins	0	DIRECT
Class I aldolase	0	DIRECT
IP3 receptor type 1 binding core, domain 2	0	DIRECT
2'-5'-oligoadenylate synthetase 1, OAS1, second domain	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
Serine carboxypeptidase-like	0	DIRECT
Group II chaperonin (CCT, TRIC), intermediate domain	0	DIRECT
Heat shock protein 90, HSP90, N-terminal domain	0	DIRECT
2Fe-2S ferredoxin domains from multidomain proteins	0	DIRECT
LON domain-like	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
Inosine monophosphate dehydrogenase (IMPDH)	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
DNA ligase	0	DIRECT
Phosphoglucomutase, C-terminal domain	0	DIRECT
BC C-terminal domain-like	0	DIRECT
DEATH effector domain, DED	0	DIRECT
D-aminoacid oxidase-like	0	DIRECT
Lesion bypass DNA polymerase (Y-family), catalytic domain	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
NagB-like	0	DIRECT
Arginase-like amidino hydrolases	0	DIRECT
PAS domain of steroid receptor coactivator 1A, NCo-A1	0	DIRECT
Oligoxyloglucan reducing end-specific cellobiohydrolase	0	DIRECT
Extracellular domain of cell surface receptors	0	DIRECT
Peptidylglycine alpha-hydroxylating monooxygenase, PHM	0	DIRECT
P-domain of calnexin/calreticulin	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
2'-5'-oligoadenylate synthetase 1, OAS1, N-terminal domain	0	DIRECT
DNA polymerase III clamp loader subunits, C-terminal domain	0	DIRECT
STAT	0	DIRECT
acyl-CoA oxidase C-terminal domains	0	DIRECT
Platelet-derived growth factor-like	0	DIRECT
SMAD MH1 domain	0	DIRECT
a tRNA synthase domain	0	DIRECT
Fibrinogen coiled-coil and central regions	0	DIRECT
Selenoprotein W-related	0	DIRECT
Tetrahydrofolate dehydrogenase/cyclohydrolase	0	DIRECT
Amyloid beta a4 protein copper binding domain (domain 2)	0	DIRECT
NOL1/NOP2/sun	0	DIRECT
SelR domain	0	DIRECT
Trunk domain of Sec23/24	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
alpha-ketoacid dehydrogenase kinase, C-terminal domain	0	DIRECT
EB1 dimerisation domain-like	0	DIRECT
ATP-dependent DNA ligase catalytic domain	0	DIRECT
14-3-3 protein	0	DIRECT
Starch-binding domain	0	DIRECT
Integrin beta tail domain	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
Transcription factor STAT-4 N-domain	0	DIRECT
beta-sandwich domain of Sec23/24	0	DIRECT
p53 DNA-binding domain-like	0	DIRECT
Occludin/ELL domain	0	DIRECT
RNA-polymerase beta	0	DIRECT
Clathrin heavy-chain linker domain	0	DIRECT
Apolipoprotein A-I	0	DIRECT
Chicken cartilage matrix protein	0	DIRECT
Transferrin	0	DIRECT
CAT-like	0	DIRECT
Osteonectin	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
Eukaryotic ODC-like	0	DIRECT
RIKEN cDNA 2310057j16 protein (KIAA1543)	0	DIRECT
Homocysteine S-methyltransferase	0	DIRECT
Cystathionine synthase-like	0	DIRECT
COMT-like	0	DIRECT
Retinoblastoma tumor suppressor domains	0	DIRECT
Serum paraoxonase/arylesterase 1, PON1	0	DIRECT
Serum albumin-like	0	DIRECT
Pumilio repeat	0	DIRECT
Ubiquitin activating enzymes (UBA)	0	DIRECT
Biotin dependent carboxylase carboxyltransferase domain	0	DIRECT
Rel/Dorsal transcription factors, DNA-binding domain	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Class I alpha-1;2-mannosidase, catalytic domain	0	DIRECT
Alanine racemase-like, N-terminal domain	0	DIRECT
Nitric oxide (NO) synthase oxygenase domain	0	DIRECT
ECR1 N-terminal domain-like	0	DIRECT
Hexokinase	0	DIRECT
FMN-linked oxidoreductases	0	DIRECT
Isoprenyl diphosphate synthases	0	DIRECT
1,3-glucuronyltransferase	0	DIRECT
Family 1 of glycosyl hydrolase	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase Pyr module	0	DIRECT
Calnexin/calreticulin	0	DIRECT
GHMP Kinase, N-terminal domain	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
Aminoacid dehydrogenase-like, C-terminal domain	0	DIRECT
PCI domain (PINT motif)	0	DIRECT
Cytidylyltransferase	0	DIRECT
Reductases	0	DIRECT
beta-glycanases	0	DIRECT
Variant SAM domain	0	DIRECT
Hsp90 middle domain	0	DIRECT
acyl-CoA oxidase N-terminal domains	0	DIRECT
Phosphoribosyltransferases (PRTases)	0	DIRECT
Pseudouridine synthase I TruA	0	DIRECT
Nop domain	0	DIRECT
Sec63 C-terminal domain-like	0	DIRECT
Biotinyl/lipoyl-carrier proteins and domains	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
Thiolase-related	0	DIRECT
Inhibitor of apoptosis (IAP) repeat	0	DIRECT
Amine oxidase catalytic domain	0	DIRECT
SAND domain	0	DIRECT
Ferredoxin domains from multidomain proteins	0	DIRECT
Tissue inhibitor of metalloproteinases, TIMP	0	DIRECT
SH3BGR (SH3-binding, glutamic acid-rich protein-like)	0	DIRECT
Malic enzyme N-domain	0	DIRECT
Protein prenylyltransferase	0	DIRECT
A heparin-binding domain	0	DIRECT
Ubiquitin carboxyl-terminal hydrolase UCH-L	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
SMAD domain	0	DIRECT
HD domain	0	DIRECT
STAT DNA-binding domain	0	DIRECT
DNA ligase/mRNA capping enzyme postcatalytic domain	0	DIRECT
CAPPD, an extracellular domain of amyloid beta A4 protein	0	DIRECT
Class II glutamine amidotransferases	0	DIRECT
UDP-glucose pyrophosphorylase	0	DIRECT
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain	0	DIRECT
BAG domain	0	DIRECT
TNF receptor-like	0	DIRECT
CAD domain	0	DIRECT
Formyltransferase	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
Leukotriene A4 hydrolase N-terminal domain	0	DIRECT
HCDH C-domain-like	0	DIRECT
Carbamilase	0	DIRECT
PAH2 domain	0	DIRECT
Cytochrome P450	0.000002021	DIRECT
Leucine zipper domain	0.0001886	DIRECT
Nuclear receptor ligand-binding domain	0.0002471	DIRECT
Nuclear receptor	0.0004226	DIRECT
Caspase recruitment domain, CARD	0.0007841	DIRECT
Cyclin	0.00784	INHERITED FROM: Paclitaxel || Polyketides || Cyclodecanes || 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid || Taxoids || apicidin
ALDH-like	0.009185	INHERITED FROM: apocarotenal || Retinaldehyde
Class I aminoacyl-tRNA synthetases (RS), catalytic domain	0.009185	INHERITED FROM: Thapsigargin || Sesquiterpenes, Guaiane
Caspase catalytic domain	0.009983	INHERITED FROM: Adamantane || Rifampin || deoxynivalenol || diepoxybutane || bafilomycin A1 || Trichothecenes || cypermethrin || Dactinomycin || Acitretin || Sesquiterpenes, Guaiane || Cyclohexanones || Amantadine || Ethers, Cyclic || Epoxy Compounds || Depsipeptides || dehydroxymethylepoxyquinomicin || Cyclohexanecarboxylic Acids || Fenretinide || Cycloheptanes || Pyrethrins || Polyketides || zinc protoporphyrin || Cyclohexanes || CD 437 || Cyclodecanes || Cyclohexanols || Menthol || Cycloparaffins || Macrolides || Lactams, Macrocyclic || methyl 5-chloro-4,5-didehydrojasmonate || Taxoids || apicidin || manganese(III)-tetrakis(4-benzoic acid)porphyrin || NSC 680410 || Cyclohexane Monoterpenes || Xanthophylls || Cyclopentanes || cobaltiprotoporphyrin
Calpain large subunit, middle domain (domain III)	0.009983	INHERITED FROM: glycidamide || Epoxy Compounds || Menthol || Cyclohexane Monoterpenes
FAD/NAD-linked reductases, N-terminal and central domains	0.009983	INHERITED FROM: Peptides, Cyclic || Cyclosporins
Proteasome subunits	0.01221	INHERITED FROM: microcystin RR || Microcystins
Integrin A (or I) domain	0.0123	INHERITED FROM: Paclitaxel || Cyclodecanes
Integrin domains	0.01303	INHERITED FROM: Cyclohexenes || Retinoids
Thyroglobulin type-1 domain	0.01622	INHERITED FROM: Tretinoin || glycidamide || Cyclohexenes || Vitamin A || Paclitaxel || Retinoids || Menthol
Alcohol dehydrogenase-like, C-terminal domain	0.01622	INHERITED FROM: apocarotenal
ABC transporter ATPase domain-like	0.01686	INHERITED FROM: Rifampin || Docetaxel || Rifamycins || Cyclodecanes || Cycloparaffins || Lactams, Macrocyclic || Taxoids
Protein kinases, catalytic subunit	0.0205	INHERITED FROM: aucubin || beta-Cyclodextrins || cyanoginosin LR || Microcystins || beta-ionone || Iridoid Glycosides || Maytansine || Polyketides || Cyclodecanes || Lycopene || 3-O-caffeoyl-1-methylquinic acid || Macrolides || Lactams, Macrocyclic || Cyclodextrins || NSC 680410 || tanespimycin
A DNA-binding domain in eukaryotic transcription factors	0.02252	INHERITED FROM: deoxynivalenol || Tretinoin || Trichothecenes || Tetrapyrroles || Epoxy Compounds || Vitamin A || Hemin
Tyrosine-dependent oxidoreductases	0.02666	INHERITED FROM: Isotretinoin || bifenthrin
Calpain large subunit, catalytic domain (domain II)	0.03177	INHERITED FROM: glycidamide || Epoxy Compounds || Menthol || Cyclohexane Monoterpenes
Heat shock protein 70kD (HSP70), C-terminal subdomain	0.03321	INHERITED FROM: Ivermectin || Tetrapyrroles || Thiostrepton || aurin || Cyclohexanecarboxylic Acids || Polyketides || Porphyrins
Bcl-2 inhibitors of programmed cell death	0.03692	INHERITED FROM: Thapsigargin || Rifampin || deoxynivalenol || diepoxybutane || IDN 5109 || Sirolimus || Trichothecenes || Dactinomycin || Ethers, Cyclic || Docetaxel || Depsipeptides || Thiostrepton || Paclitaxel || destruxin B || beta Carotene || Fenretinide || Pyrethrins || Polyketides || Cyclohexanes || Cyclohexanols || Menthol || Cycloparaffins || Epichlorohydrin || 2,2-bis(4-glycidyloxyphenyl)propane || pramanicin || Lutein || tanespimycin || Cyclohexane Monoterpenes || Xanthophylls || Epothilones
Short-chain cytokines	0.04826	INHERITED FROM: deoxynivalenol || Tacrolimus || Trichothecenes || Alitretinoin || Cyclohexenes || Cyclohexanecarboxylic Acids || brevetoxin 2 || Oxocins || Retinoids || Polyketides
C2 set domains	0.04887	INHERITED FROM: Cyclohexenes || Carotenoids || Retinoids || Polyketides || Cyclohexanes || Macrolides
Tandem AAA-ATPase domain	0.05147	INHERITED FROM: Cyclosporins
Alcohol dehydrogenase-like, N-terminal domain	0.05468	INHERITED FROM: apocarotenal
Integrin alpha N-terminal domain	0.05468	INHERITED FROM: Cyclohexenes || Retinoids
Leukotriene A4 hydrolase catalytic domain	0.0626	INHERITED FROM: Peptides, Cyclic || Cyclosporins
Metallothionein	0.0626	INHERITED FROM: Sirolimus || Tetrapyrroles || Metalloporphyrins || Macrolides || motexafin gadolinium || Porphyrins
L domain	0.1027	INHERITED FROM: Paclitaxel || Polyketides || Cyclopentanes
Mitochondrial carrier	0.1029	INHERITED FROM: Thapsigargin || Sesquiterpenes, Guaiane || Cycloheptanes || CD 437 || enniatins
MIF4G domain-like	0.1046	INHERITED FROM: Tretinoin || Vitamin A || Polyketides || Macrolides
Cell cycle control phosphatase, catalytic domain	0.1046	INHERITED FROM: Trichothecenes
Arylsulfatase	0.1052	INHERITED FROM: Oxocins || yessotoxin
Group II chaperonin (CCT, TRIC), ATPase domain	0.1149	INHERITED FROM: Adamantane || Okadaic Acid || CD 437 || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid
Cell cycle transcription factor e2f-dp	0.1149	INHERITED FROM: Paclitaxel || Cyclohexanols || Menthol || Cyclohexane Monoterpenes
YWTD domain	0.1296	INHERITED FROM: Peptides, Cyclic || Bile Pigments || Cyclosporins
Phoshoinositide 3-kinase (PI3K), catalytic domain	0.1296	INHERITED FROM: Oxocins || motexafin gadolinium
Glutathione peroxidase-like	0.1307	INHERITED FROM: glycidamide || Ethers, Cyclic || Tetrapyrroles
NADPH-cytochrome p450 reductase FAD-binding domain-like	0.1471	INHERITED FROM: Tacrolimus || Tetrapyrroles || Metalloporphyrins || Polyketides
E2F dimerization segment	0.1471	INHERITED FROM: Paclitaxel || Cyclodecanes || Menthol || Taxoids || Cyclohexane Monoterpenes
NADPH-cytochrome p450 reductase-like	0.1471	INHERITED FROM: Tacrolimus || Tetrapyrroles || Metalloporphyrins || Polyketides
Penta-EF-hand proteins	0.1586	INHERITED FROM: Cyclohexanols || Menthol || Cyclohexane Monoterpenes
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain	0.1586	INHERITED FROM: deoxynivalenol || Trichothecenes
UDPGT-like	0.1622	INHERITED FROM: Rifampin || Cyclohexanecarboxylic Acids || Bile Pigments
Aldo-keto reductases (NADP)	0.1651	INHERITED FROM: glycidamide || Ethers, Cyclic || 9-cis-retinal || cyclopentanol || cyclopentanone || Retinaldehyde
Cyclophilin (peptidylprolyl isomerase)	0.1651	INHERITED FROM: Oxocins || yessotoxin
DNA replication initiator (cdc21/cdc54) N-terminal domain	0.172	INHERITED FROM: Thapsigargin || Sesquiterpenes, Guaiane || Cycloheptanes
DEATH domain, DD	0.1753	INHERITED FROM: Paclitaxel || beta Carotene || apocarotenal || Cyclodecanes || Cyclohexanols || Cyclohexane Monoterpenes
EGF-type module	0.1829	INHERITED FROM: Retinoids || Chlorogenic Acid
ABC transporter transmembrane region	0.1851	INHERITED FROM: Rifampin || Dactinomycin || Docetaxel || Rifamycins || Cyclodecanes || Cycloparaffins || Lactams, Macrocyclic || Taxoids
Glutathione S-transferase (GST), C-terminal domain	0.202	INHERITED FROM: microcystin RR || apple polyphenol extract || Microcystins || Tetrapyrroles || beta Carotene || apocarotenal || Okadaic Acid || Bile Pigments
Hemopexin-like domain	0.216	INHERITED FROM: Tetrapyrroles || Paclitaxel || Cyclodecanes || Porphyrins || manganese(III)-tetrakis(4-benzoic acid)porphyrin || cyclo(Trp-Asp-Pro-Val-Leu) || Chlorogenic Acid || 3-caffeoyl-4-dihydrocaffeoylquinic acid
Matrix metalloproteases, catalytic domain	0.216	INHERITED FROM: Tetrapyrroles || Paclitaxel || Cycloparaffins || Porphyrins || manganese(III)-tetrakis(4-benzoic acid)porphyrin || cyclo(Trp-Asp-Pro-Val-Leu) || Chlorogenic Acid || 3-caffeoyl-4-dihydrocaffeoylquinic acid
Interferon regulatory factor 3 (IRF3), transactivation domain	0.219	INHERITED FROM: Paclitaxel
Growth factor receptor domain	0.2283	INHERITED FROM: Cyclohexenes || Paclitaxel
PDI-like	0.2344	INHERITED FROM: Thapsigargin || Sesquiterpenes, Guaiane || Cycloheptanes
Group II chaperonin (CCT, TRIC), apical domain	0.2364	INHERITED FROM: Adamantane || Okadaic Acid || CD 437 || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid
Fibronectin type II module	0.2364	INHERITED FROM: Tetrapyrroles || Porphyrins
Tubulin, C-terminal domain	0.2509	INHERITED FROM: Thapsigargin || Sesquiterpenes, Guaiane || 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol
Canonical RBD	0.273	INHERITED FROM: Oxocins || yessotoxin || pateamine A || 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol
BTG domain-like	0.2778	INHERITED FROM: LG 100815
C1 set domains (antibody constant domain-like)	0.2876	INHERITED FROM: Erythromycin
PDEase	0.2885	INHERITED FROM: Cyclohexanecarboxylic Acids || Cyclopropanes || Roflumilast || Cilomilast
Laminin G-like module	0.2889	INHERITED FROM: Retinoids || Cyclohexanes
Serpins	0.3165	INHERITED FROM: Rifampin
S100 proteins	0.3216	INHERITED FROM: 4-oxoretinoic acid || Alitretinoin
Cytochrome b5	0.3369	INHERITED FROM: Isotretinoin
MPP-like	0.3475	INHERITED FROM: Isotretinoin
Cytochrome p450 reductase N-terminal domain-like	0.3475	INHERITED FROM: Tacrolimus || Metalloporphyrins || Polyketides || Porphyrins
MHC antigen-recognition domain	0.3665	INHERITED FROM: Erythromycin
Nucleoside diphosphate kinase, NDK	0.3687	INHERITED FROM: Menthol || Cyclohexane Monoterpenes
MMP N-terminal domain	0.3766	INHERITED FROM: Tetrapyrroles || Paclitaxel || Cyclohexanecarboxylic Acids || Cyclodecanes || Porphyrins || manganese(III)-tetrakis(4-benzoic acid)porphyrin || cyclo(Trp-Asp-Pro-Val-Leu) || Chlorogenic Acid || 3-caffeoyl-4-dihydrocaffeoylquinic acid
Long-chain cytokines	0.3784	INHERITED FROM: deoxynivalenol || Trichothecenes
Tubulin, GTPase domain	0.384	INHERITED FROM: Thapsigargin || Sesquiterpenes, Guaiane || 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol
Glutathione S-transferase (GST), N-terminal domain	0.384	INHERITED FROM: beta Carotene || apocarotenal || Cyclohexanes
Toll/Interleukin receptor TIR domain	0.384	INHERITED FROM: Ivermectin || Paclitaxel || Cyclodecanes
Sm motif of small nuclear ribonucleoproteins, SNRNP	0.4013	INHERITED FROM: Adamantane || Ethers, Cyclic || Oxocins || yessotoxin || CD 437 || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid
Bromodomain	0.421	INHERITED FROM: deoxynivalenol
Translational machinery components	0.4516	INHERITED FROM: CD 437
Frizzled cysteine-rich domain	0.5295	INHERITED FROM: Tretinoin || Vitamin A
Cold shock DNA-binding domain-like	0.5425	INHERITED FROM: Depsipeptides || beauvericin
SH2 domain	0.5485	INHERITED FROM: 4-acetylantroquinonol B || Cyclohexanones
Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain	0.558	INHERITED FROM: Isotretinoin
Actin/HSP70	0.5661	INHERITED FROM: Ivermectin || Thiostrepton || Hemin || aurin || Cyclohexanecarboxylic Acids || Metalloporphyrins
Small Kunitz-type inhibitors & BPTI-like toxins	0.5814	INHERITED FROM: Paclitaxel || Cyclodecanes
Clathrin coat assembly domain	0.5991	INHERITED FROM: Oxocins || yessotoxin
Hypoxia-inducible factor Hif2a, C-terminal domain	0.5991	INHERITED FROM: Rifampin || Rifamycins || Okadaic Acid
Transforming growth factor (TGF)-beta	0.6206	INHERITED FROM: Protoporphyrins || brevetoxin 2 || Oxocins || Octreotide
Interleukin-1 (IL-1)	0.6226	INHERITED FROM: Metalloporphyrins || Polyketides
G proteins	0.6523	INHERITED FROM: 15-acetyldeoxynivalenol
Prefoldin	0.6547	INHERITED FROM: 4-oxoretinoic acid || Alitretinoin
PAPS sulfotransferase	0.7	INHERITED FROM: glycidamide
TNF-like	0.7127	INHERITED FROM: brevetoxin 2 || Cyclohexanols || Menthol || Cyclohexane Monoterpenes
MATH domain	0.7266	INHERITED FROM: Paclitaxel || Cyclodecanes || Cyclohexanols || Menthol || Cyclohexane Monoterpenes
Synaptotagmin-like (S variant)	0.7728	INHERITED FROM: Bryostatins
SNF-like	0.7747	INHERITED FROM: 2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone || Cyclohexanones || Cyclohexylamines
CCCH zinc finger	0.7875	INHERITED FROM: 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)	0.807	INHERITED FROM: Bryostatins
Interleukin 8-like chemokines	0.8476	INHERITED FROM: Trichothecenes || beta Carotene || Polyketides || Cyclopropanes || 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol || primycin || pevonedistat || Roflumilast || Antimycin A || roflumilast N-oxide
Acetylcholinesterase-like	0.8602	INHERITED FROM: Pyrethrins || Cyclopentane Monoterpenes
HLH, helix-loop-helix DNA-binding domain	0.9308	INHERITED FROM: Rifampin
Chaperone J-domain	0.9899	INHERITED FROM: motexafin gadolinium
Cadherin	1	INHERITED FROM: jasplakinolide
Interferons/interleukin-10 (IL-10)	1	INHERITED FROM: beta Carotene || apocarotenal
Homeodomain	1	INHERITED FROM: beta Carotene || apocarotenal
Nicotinic receptor ligand binding domain-like	1	INHERITED FROM: carvone || menthone || Picrotoxin
Intermediate filament protein, coiled coil region	1	INHERITED FROM: Isotretinoin || 4-oxoretinoic acid || Alitretinoin || Microcystins || beta Carotene || 4-oxoretinol || ethyl-p-((E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-1-propenyl)benzoic acid
Neurotransmitter-gated ion-channel transmembrane pore	1	INHERITED FROM: carvone || menthone || Picrotoxin

Supra-domain (Single|Duplex|Triple)

Supra-domain (Single)

Highlighted in gray are those with FDR>0.001

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
PAH2 domain	0	DIRECT
Transcription factor STAT-4 N-domain	0	DIRECT
Rudiment single hybrid motif	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	DIRECT
Seven-hairpin glycosidases	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
Chicken cartilage matrix protein	0	DIRECT
beta-lactamase/transpeptidase-like	0	DIRECT
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain	0	DIRECT
Fibrinogen coiled-coil and central regions	0	DIRECT
p53 tetramerization domain	0	DIRECT
Amine oxidase catalytic domain	0	DIRECT
BAG domain	0	DIRECT
Inosine monophosphate dehydrogenase (IMPDH)	0	DIRECT
Alanine racemase C-terminal domain-like	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
FMN-linked oxidoreductases	0	DIRECT
ATP-dependent DNA ligase DNA-binding domain	0	DIRECT
Phosphoenolpyruvate/pyruvate domain	0	DIRECT
Protein prenylyltransferase	0	DIRECT
Single hybrid motif	0	DIRECT
Integrin beta tail domain	0	DIRECT
PriA/YqbF domain	0	DIRECT
S15/NS1 RNA-binding domain	0	DIRECT
Zn-finger domain of Sec23/24	0	DIRECT
PK beta-barrel domain-like	0	DIRECT
Serum albumin-like	0	DIRECT
14-3-3 protein	0	DIRECT
FMT C-terminal domain-like	0	DIRECT
A heparin-binding domain	0	DIRECT
PLP-binding barrel	0	DIRECT
CAPPD, an extracellular domain of amyloid beta A4 protein	0	DIRECT
Alpha-L RNA-binding motif	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Apolipoprotein A-I	0	DIRECT
Nitric oxide (NO) synthase oxygenase domain	0	DIRECT
Di-copper centre-containing domain	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
SIS domain	0	DIRECT
Mediator hinge subcomplex-like	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
4Fe-4S ferredoxins	0	DIRECT
Aminoacid dehydrogenase-like, N-terminal domain	0	DIRECT
P-domain of calnexin/calreticulin	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
EB1 dimerisation domain-like	0	DIRECT
Nucleotide-binding domain	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
Nicotinate/Quinolinate PRTase C-terminal domain-like	0	DIRECT
alpha-ketoacid dehydrogenase kinase, N-terminal domain	0	DIRECT
Amine oxidase N-terminal region	0	DIRECT
Amyloid beta a4 protein copper binding domain (domain 2)	0	DIRECT
Inhibitor of apoptosis (IAP) repeat	0	DIRECT
PRC-barrel domain	0	DIRECT
occludin/ELL-like	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
AhpD-like	0	DIRECT
Nop domain	0	DIRECT
Phosphoglucomutase, C-terminal domain	0	DIRECT
PHM/PNGase F	0	DIRECT
ISP domain	0	DIRECT
Formyltransferase	0	DIRECT
Ribosomal protein L16p/L10e	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
SMAD MH1 domain	0	DIRECT
EPT/RTPC-like	0	DIRECT
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	0	DIRECT
FAD-linked oxidoreductase	0	DIRECT
Helical domain of Sec23/24	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
Nuclear receptor coactivator interlocking domain	0	DIRECT
Activating enzymes of the ubiquitin-like proteins	0	DIRECT
GINS helical bundle-like	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
Homocysteine S-methyltransferase	0	DIRECT
STAT	0	DIRECT
Cytochrome P450	0.0000005491	DIRECT
NAD(P)-binding Rossmann-fold domains	0.000009607	DIRECT
Leucine zipper domain	0.00009212	DIRECT
Thioredoxin-like	0.0001143	DIRECT
Nuclear receptor ligand-binding domain	0.0001171	DIRECT
TNF receptor-like	0.001776	INHERITED FROM: Cyclohexanols || Epoxy Compounds || motexafin gadolinium || Cyclohexanes || Menthol || Nystatin || Paclitaxel || Cyclohexane Monoterpenes || Cycloparaffins || 4-(3-(1-adamantyl)-4-hydroxyphenyl)-3-chlorocinnamic acid
Caspase-like	0.002995	INHERITED FROM: cypermethrin || diepoxybutane || Cyclopentanes || Cycloheptanes || Sesquiterpenes, Guaiane || Cyclohexanols || Epoxy Compounds || bafilomycin A1 || Cyclodecanes || Ethers, Cyclic || Cyclohexanes || Lactams, Macrocyclic || apicidin || Cyclohexanones || Amantadine || Menthol || Rifampin || manganese(III)-tetrakis(4-benzoic acid)porphyrin || Cyclohexane Monoterpenes || Macrolides || Xanthophylls || Trichothecenes || Taxoids || Cyclohexanecarboxylic Acids || zinc protoporphyrin || NSC 680410 || Acitretin || deoxynivalenol || Adamantane || Pyrethrins || Depsipeptides || surfactin peptide || Polyketides || Fenretinide || cobaltiprotoporphyrin || CD 437 || dehydroxymethylepoxyquinomicin || methyl 5-chloro-4,5-didehydrojasmonate || Dactinomycin || Ketamine
ALDH-like	0.006185	INHERITED FROM: Retinaldehyde || apocarotenal
Calpain large subunit, middle domain (domain III)	0.007219	INHERITED FROM: Cyclohexanols || Epoxy Compounds || Menthol || Cyclohexane Monoterpenes || glycidamide
Integrin domains	0.008601	INHERITED FROM: Cyclohexenes || Retinoids
Aldolase	0.01112	INHERITED FROM: Peptides, Cyclic || Cyclosporins
Thyroglobulin type-1 domain	0.01135	INHERITED FROM: Epoxy Compounds || Cyclohexenes || Menthol || Paclitaxel || Retinoids || glycidamide || Vitamin A || Tretinoin
Protein kinase-like (PK-like)	0.01372	INHERITED FROM: methyleugenol-2',3'-epoxide || 4-acetylantroquinonol B || Cyclodecanes || Iridoid Glycosides || Lactams, Macrocyclic || aucubin || Cyclodextrins || Cyclohexane Monoterpenes || Macrolides || beta-Cyclodextrins || Sirolimus || tanespimycin || Microcystins || NSC 680410 || beta-ionone || 3-O-caffeoyl-1-methylquinic acid || Polyketides || Lycopene || Iridoids || cyanoginosin LR || Maytansine
Glucocorticoid receptor-like (DNA-binding domain)	0.0142	INHERITED FROM: 4-hydroxyretinoic acid || 9-cis-retinal || diisononyl 1,2-cyclohexanedicarboxylic acid || Cyclopentanes || phenothrin || Bexarotene || Lactams, Macrocyclic || 2,2-bis(4-glycidyloxyphenyl)propane || SR 11237 || 1,1-bis(4-hydroxyphenyl)cyclohexane || ethofenprox || 3-acetyldeoxynivalenol || Cyclohexanecarboxylic Acids || Permethrin || Ciclopirox || cyhalothrin || Alitretinoin || Retinaldehyde || Pyrethrins || Valinomycin || Fenretinide || Cyclopentane Monoterpenes || 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid || beta Carotene || fenvalerate || 4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid
A DNA-binding domain in eukaryotic transcription factors	0.01664	INHERITED FROM: Epoxy Compounds || Tetrapyrroles || Rifampin || Trichothecenes || Retinoids || deoxynivalenol || Vitamin A || Hemin || Tretinoin
PLP-dependent transferases	0.02191	INHERITED FROM: Cyclosporins
Cyclin-like	0.02191	INHERITED FROM: Cyclodecanes || Ethers, Cyclic || apicidin || Paclitaxel || Macrolides || Taxoids || Depsipeptides || Polyketides || Fenretinide || 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid
Heat shock protein 70kD (HSP70), C-terminal subdomain	0.02569	INHERITED FROM: Thiostrepton || Sesquiterpenes, Guaiane || Tetrapyrroles || Porphyrins || Thapsigargin || Cyclohexanecarboxylic Acids || Polyketides || Ivermectin || aurin
Ribosomal protein S5 domain 2-like	0.02594	INHERITED FROM: CD 437
Bcl-2 inhibitors of programmed cell death	0.02742	INHERITED FROM: Thiostrepton || diepoxybutane || Cyclohexanols || Docetaxel || destruxin B || Ethers, Cyclic || Epothilones || Cyclohexanes || 2,2-bis(4-glycidyloxyphenyl)propane || Thapsigargin || Epichlorohydrin || Menthol || Rifampin || Paclitaxel || Cyclohexane Monoterpenes || Cycloparaffins || Xanthophylls || Trichothecenes || Sirolimus || tanespimycin || pramanicin || Lutein || deoxynivalenol || Pyrethrins || Depsipeptides || Polyketides || IDN 5109 || Fenretinide || beta Carotene || Dactinomycin
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0.03165	INHERITED FROM: Sesquiterpenes, Guaiane || Thapsigargin
GroES-like	0.03165	INHERITED FROM: apocarotenal
Nucleic acid-binding proteins	0.03628	INHERITED FROM: Cycloheptanes || Sesquiterpenes, Guaiane || Thapsigargin || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || beauvericin || Adamantane || Quinic Acid || CD 437
Kringle-like	0.04632	INHERITED FROM: Tetrapyrroles || Porphyrins || genipin || Iridoids || Dactinomycin
Leukotriene A4 hydrolase N-terminal domain	0.04829	INHERITED FROM: Peptides, Cyclic || Cyclosporins
Metallothionein	0.04829	INHERITED FROM: motexafin gadolinium || Tetrapyrroles || Porphyrins || Macrolides || Sirolimus || Metalloporphyrins
GST C-terminal domain-like	0.05563	INHERITED FROM: Okadaic Acid || Tetrapyrroles || apple polyphenol extract || Microcystins || Bile Pigments || microcystin RR || apocarotenal || beta Carotene
vWA-like	0.06561	INHERITED FROM: Cyclodecanes
GroEL-intermediate domain like	0.06771	INHERITED FROM: Okadaic Acid || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Adamantane || Ivermectin || CD 437
Mitochondrial carrier	0.07254	INHERITED FROM: Cycloheptanes || Sesquiterpenes, Guaiane || Thapsigargin || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || CD 437 || enniatins
FAD/NAD(P)-binding domain	0.07669	INHERITED FROM: Xanthophylls || Cyclosporins
TPR-like	0.07705	INHERITED FROM: Peptides, Cyclic || Cyclosporins
Thiolase-like	0.08397	INHERITED FROM: Isotretinoin || Polyketides
Sm-like ribonucleoproteins	0.08704	INHERITED FROM: Ethers, Cyclic || yessotoxin || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Adamantane || Oxocins || CD 437
CoA-dependent acyltransferases	0.09385	INHERITED FROM: Isotretinoin
Alkaline phosphatase-like	0.09814	INHERITED FROM: yessotoxin || Oxocins
YWTD domain	0.1029	INHERITED FROM: Peptides, Cyclic || Bile Pigments || Cyclosporins
Cyclophilin-like	0.1053	INHERITED FROM: yessotoxin || Oxocins
Nucleotidylyl transferase	0.1162	INHERITED FROM: Sesquiterpenes, Guaiane || Thapsigargin || 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol
GroEL equatorial domain-like	0.1185	INHERITED FROM: Okadaic Acid || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Adamantane || Ivermectin || CD 437
GroEL apical domain-like	0.1185	INHERITED FROM: Okadaic Acid || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Adamantane || Ivermectin || CD 437
Lipocalins	0.1221	INHERITED FROM: 4-oxoretinoic acid
Growth factor receptor domain	0.1244	INHERITED FROM: Cyclodecanes || Paclitaxel
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0.1257	INHERITED FROM: Microcystins || microcystin RR
Prefoldin	0.1265	INHERITED FROM: 4-oxoretinol || Bexarotene || 4-oxoretinoic acid || Alitretinoin || beta Carotene || ethyl-p-((E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-1-propenyl)benzoic acid
Zn-binding ribosomal proteins	0.1284	INHERITED FROM: 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Adamantane || CD 437
Flavoproteins	0.1284	INHERITED FROM: Tetrapyrroles || Porphyrins || Polyketides
NAD(P)-linked oxidoreductase	0.1353	INHERITED FROM: 9-cis-retinal || Ethers, Cyclic || cyclopentanol || Retinaldehyde || glycidamide || cyclopentanone
BRCT domain	0.1468	INHERITED FROM: Fenretinide
Riboflavin synthase domain-like	0.1555	INHERITED FROM: Tacrolimus
Ferredoxin reductase-like, C-terminal NADP-linked domain	0.1555	INHERITED FROM: Tacrolimus
ClpP/crotonase	0.1562	INHERITED FROM: Isotretinoin
ABC transporter transmembrane region	0.1594	INHERITED FROM: Docetaxel || Cyclodecanes || Lactams, Macrocyclic || Rifampin || Cycloparaffins || Taxoids || Rifamycins || Dactinomycin
Hemopexin-like domain	0.1733	INHERITED FROM: Chlorogenic Acid || Cyclodecanes || Tetrapyrroles || Porphyrins || 3-caffeoyl-4-dihydrocaffeoylquinic acid || Paclitaxel || manganese(III)-tetrakis(4-benzoic acid)porphyrin || cyclo(Trp-Asp-Pro-Val-Leu)
E2F-DP heterodimerization region	0.1735	INHERITED FROM: Cyclohexanols || Menthol || Paclitaxel || Cyclohexane Monoterpenes
Carbon-nitrogen hydrolase	0.1851	INHERITED FROM: Isotretinoin
FnI-like domain	0.1941	INHERITED FROM: Tetrapyrroles || Porphyrins || Dactinomycin
Tubulin C-terminal domain-like	0.204	INHERITED FROM: Cycloheptanes || Sesquiterpenes, Guaiane || Thapsigargin || 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol
DEATH domain	0.2041	INHERITED FROM: cypermethrin || Cyclopentanes || nodularin || Cyclohexanols || Cyclodecanes || Ethers, Cyclic || Tetrapyrroles || Cyclohexanones || Porphyrins || Epichlorohydrin || Menthol || Nystatin || Cyclohexane Monoterpenes || Cycloparaffins || Macrolides || Taxoids || Acitretin || bis(acetato)(1-adamantylamine)amminedichloroplatinum(IV) || Pyrethrins || brevetoxin 2 || Depsipeptides || Oxocins || 4-(3-(1-adamantyl)-4-hydroxyphenyl)-3-chlorocinnamic acid || Polyketides || Fenretinide || beta Carotene || dehydroxymethylepoxyquinomicin || methyl 5-chloro-4,5-didehydrojasmonate || Dactinomycin
UDP-Glycosyltransferase/glycogen phosphorylase	0.2071	INHERITED FROM: Cyclohexanecarboxylic Acids
EGF/Laminin	0.2244	INHERITED FROM: Cycloparaffins
Serpins	0.2272	INHERITED FROM: Rifampin || Alitretinoin
BTG domain-like	0.2389	INHERITED FROM: LG 100815
HD-domain/PDEase-like	0.2478	INHERITED FROM: Roflumilast || Cyclopropanes || Cyclohexanecarboxylic Acids || Cilomilast
P-loop containing nucleoside triphosphate hydrolases	0.2527	INHERITED FROM: Docetaxel || Cyclodecanes || taxane || Taxoids
Class II aaRS and biotin synthetases	0.2843	INHERITED FROM: Cycloheptanes || Sesquiterpenes, Guaiane || Thapsigargin
p53-like transcription factors	0.2881	INHERITED FROM: Cyclopentanes || Cyclohexanones || Macrolides || Trichothecenes || deoxynivalenol || pevonedistat || Polyketides || Dactinomycin
LuxS/MPP-like metallohydrolase	0.3058	INHERITED FROM: Isotretinoin
Ferritin-like	0.3058	INHERITED FROM: Cyclodecanes || Paclitaxel
MHC antigen-recognition domain	0.3081	INHERITED FROM: Isotretinoin || Erythromycin
L30e-like	0.3102	INHERITED FROM: Ethers, Cyclic
Cytochrome b5-like heme/steroid binding domain	0.3102	INHERITED FROM: Isotretinoin
L27 domain	0.3102	INHERITED FROM: geldanamycin
(Trans)glycosidases	0.3119	INHERITED FROM: yessotoxin || Oxocins
PGBD-like	0.3193	INHERITED FROM: Chlorogenic Acid || Cyclodecanes || Tetrapyrroles || Porphyrins || 3-caffeoyl-4-dihydrocaffeoylquinic acid || Paclitaxel || manganese(III)-tetrakis(4-benzoic acid)porphyrin || cyclo(Trp-Asp-Pro-Val-Leu) || Cyclohexanecarboxylic Acids
CAD & PB1 domains	0.3193	INHERITED FROM: Cyclohexanols || Menthol || Cyclohexane Monoterpenes
Tubulin nucleotide-binding domain-like	0.3231	INHERITED FROM: Cycloheptanes || Sesquiterpenes, Guaiane || Thapsigargin || 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol
Bromodomain	0.3468	INHERITED FROM: Trichothecenes || deoxynivalenol
Actin-like ATPase domain	0.3514	INHERITED FROM: Thiostrepton || yessotoxin || Ivermectin || Hemin || aurin
TRAF domain-like	0.3669	INHERITED FROM: Cyclohexanols || Menthol || Cyclohexane Monoterpenes
Cysteine-rich domain	0.3818	INHERITED FROM: Bryostatins
Toll/Interleukin receptor TIR domain	0.4068	INHERITED FROM: Cyclodecanes || Paclitaxel || Ivermectin
4-helical cytokines	0.4104	INHERITED FROM: primycin || Ethers, Cyclic || Tetrapyrroles || Trichothecenes || Cyclohexanecarboxylic Acids || helenalin || Alitretinoin || deoxynivalenol || brevetoxin 2 || Oxocins || Polyketides || Cilomilast || apocarotenal || Clarithromycin || Dactinomycin
SH2 domain	0.4423	INHERITED FROM: 4-acetylantroquinonol B || Cyclohexanones
Fibronectin type III	0.4445	INHERITED FROM: Cycloparaffins
Frizzled cysteine-rich domain	0.4633	INHERITED FROM: Cyclohexanes || Retinoids || Vitamin A || Tretinoin
DNA/RNA polymerases	0.4734	INHERITED FROM: diepoxybutane || Epoxy Compounds
Nucleoside diphosphate kinase, NDK	0.4773	INHERITED FROM: Menthol || Cyclohexane Monoterpenes
TK C-terminal domain-like	0.5069	INHERITED FROM: Isotretinoin
Cystine-knot cytokines	0.5298	INHERITED FROM: Protoporphyrins || Octreotide || Alitretinoin || Oxocins
Thiamin diphosphate-binding fold (THDP-binding)	0.5419	INHERITED FROM: Isotretinoin
RNA-binding domain, RBD	0.6006	INHERITED FROM: pateamine A || yessotoxin || 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol
SMAD/FHA domain	0.6061	INHERITED FROM: Iridoid Glycosides || aucubin || Iridoid Glucosides || Iridoids
Orange domain-like	0.631	INHERITED FROM: Cycloheptanes || Sesquiterpenes, Guaiane || Thapsigargin
BPTI-like	0.6405	INHERITED FROM: Cyclodecanes || Paclitaxel || Taxoids
MFS general substrate transporter	0.6584	INHERITED FROM: Lactams, Macrocyclic || Rifampin || Rifamycins || Nateglinide || Erythromycin
TNF-like	0.66	INHERITED FROM: Cyclohexanols || Menthol || Cyclohexane Monoterpenes || brevetoxin 2
Rhodanese/Cell cycle control phosphatase	0.676	INHERITED FROM: Trichothecenes || glycidamide
SNF-like	0.7063	INHERITED FROM: 2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone || Cyclohexanones || Cyclohexylamines
CCCH zinc finger	0.7207	INHERITED FROM: 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol
C2 domain (Calcium/lipid-binding domain, CaLB)	0.76	INHERITED FROM: Bryostatins
Interleukin 8-like chemokines	0.7696	INHERITED FROM: primycin || roflumilast N-oxide || Roflumilast || Antimycin A || Cyclopropanes || Trichothecenes || 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol || pevonedistat || Polyketides || beta Carotene
SNARE-like	0.7898	INHERITED FROM: yessotoxin
PYP-like sensor domain (PAS domain)	0.8075	INHERITED FROM: Cyclopentanes || Lactams, Macrocyclic || Rifampin || Rifamycins || Polyketides
HLH, helix-loop-helix DNA-binding domain	0.855	INHERITED FROM: Rifampin
Chaperone J-domain	0.9352	INHERITED FROM: motexafin gadolinium
TSP-1 type 1 repeat	0.9377	INHERITED FROM: Paclitaxel
Metalloproteases ("zincins"), catalytic domain	0.9456	INHERITED FROM: 3-caffeoyl-4-dihydrocaffeoylquinic acid || manganese(III)-tetrakis(4-benzoic acid)porphyrin || cyclo(Trp-Asp-Pro-Val-Leu)
Translation proteins SH3-like domain	0.9775	INHERITED FROM: 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Adamantane
Intermediate filament protein, coiled coil region	0.9776	INHERITED FROM: Isotretinoin || 4-oxoretinol || Microcystins || 4-oxoretinoic acid || Alitretinoin || beta Carotene || ethyl-p-((E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-1-propenyl)benzoic acid
Neurotransmitter-gated ion-channel transmembrane pore	0.9921	INHERITED FROM: Picrotoxin || menthone || carvone
Nicotinic receptor ligand binding domain-like	0.9921	INHERITED FROM: Picrotoxin || menthone || carvone
Homeodomain-like	1	INHERITED FROM: apocarotenal || beta Carotene
Immunoglobulin	1	INHERITED FROM: helenalin
Cadherin-like	1	INHERITED FROM: jasplakinolide

Supra-domain (Duplex) in N- to C-terminal order

Highlighted in gray are those with FDR>0.001

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
100920,100934 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
47576,140612 47576 - Calponin-homology domain, CH-domain 140612 - EB1 dimerisation domain-like	0	DIRECT
82919,53300 82919 - Zn-finger domain of Sec23/24 53300 - vWA-like	0	DIRECT
53067,100920 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
57630,57196 57630 - GLA-domain 57196 - EGF/Laminin	0	DIRECT
81995,81811 81995 - beta-sandwich domain of Sec23/24 81811 - Helical domain of Sec23/24	0	DIRECT
54403,54403 54403 - Cystatin/monellin 54403 - Cystatin/monellin	0	DIRECT
47005,52777 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex 52777 - CoA-dependent acyltransferases	0	DIRECT
56491,89811 56491 - A heparin-binding domain 89811 - Amyloid beta a4 protein copper binding domain (domain 2)	0	DIRECT
51905,55424 51905 - FAD/NAD(P)-binding domain 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
69012,55874 69012 - alpha-ketoacid dehydrogenase kinase, N-terminal domain 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0	DIRECT
46966,51045 46966 - Spectrin repeat 51045 - WW domain	0	DIRECT
48452,57850 48452 - TPR-like 57850 - RING/U-box	0	DIRECT
102848,54236 102848 - NSFL1 (p97 ATPase) cofactor p47, SEP domain 54236 - Ubiquitin-like	0	DIRECT
82895,57424 82895 - TSP-1 type 1 repeat 57424 - LDL receptor-like module	0	DIRECT
48552,48552 48552 - Serum albumin-like 48552 - Serum albumin-like	0	DIRECT
141673,50800 141673 - MOSC N-terminal domain-like 50800 - PK beta-barrel domain-like	0	DIRECT
56059,52210 56059 - Glutathione synthetase ATP-binding domain-like 52210 - Succinyl-CoA synthetase domains	0	DIRECT
53300,81995 53300 - vWA-like 81995 - beta-sandwich domain of Sec23/24	0	DIRECT
57196,50494 57196 - EGF/Laminin 50494 - Trypsin-like serine proteases	0	DIRECT
57535,57196 57535 - Complement control module/SCR domain 57196 - EGF/Laminin	0	DIRECT
69572,69572 69572 - Activating enzymes of the ubiquitin-like proteins 69572 - Activating enzymes of the ubiquitin-like proteins	0	DIRECT
49562,57889 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 57889 - Cysteine-rich domain	0	DIRECT
51419,50621 51419 - PLP-binding barrel 50621 - Alanine racemase C-terminal domain-like	0	DIRECT
47060,55681 47060 - S15/NS1 RNA-binding domain 55681 - Class II aaRS and biotin synthetases	0	DIRECT
57184,57610 57184 - Growth factor receptor domain 57610 - Thyroglobulin type-1 domain	0	DIRECT
53738,53738 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains	0	DIRECT
54236,57889 54236 - Ubiquitin-like 57889 - Cysteine-rich domain	0	DIRECT
-8,54980 -8 - ECOD 54980 - EF-G C-terminal domain-like	0	DIRECT
54416,54416 54416 - Amine oxidase N-terminal region 54416 - Amine oxidase N-terminal region	0	DIRECT
47113,-7 47113 - Histone-fold -7 - CATH	0	DIRECT
54416,49998 54416 - Amine oxidase N-terminal region 49998 - Amine oxidase catalytic domain	0	DIRECT
50993,53474 50993 - Peptidase/esterase 'gauge' domain 53474 - alpha/beta-Hydrolases	0	DIRECT
100934,100934 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
49417,47719 49417 - p53-like transcription factors 47719 - p53 tetramerization domain	0	DIRECT
51045,47473 51045 - WW domain 47473 - EF-hand	0	DIRECT
54211,55666 54211 - Ribosomal protein S5 domain 2-like 55666 - Ribonuclease PH domain 2-like	0	DIRECT
53223,51735 53223 - Aminoacid dehydrogenase-like, N-terminal domain 51735 - NAD(P)-binding Rossmann-fold domains	0	DIRECT
48403,52540 48403 - Ankyrin repeat 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
55753,47050 55753 - Actin depolymerizing proteins 47050 - VHP, Villin headpiece domain	0	DIRECT
48092,47655 48092 - Transcription factor STAT-4 N-domain 47655 - STAT	0	DIRECT
57196,57535 57196 - EGF/Laminin 57535 - Complement control module/SCR domain	0	DIRECT
48403,48452 48403 - Ankyrin repeat 48452 - TPR-like	0	DIRECT
90188,53649 90188 - Somatomedin B domain 53649 - Alkaline phosphatase-like	0	DIRECT
49503,49503 49503 - Cupredoxins 49503 - Cupredoxins	0	DIRECT
100895,100895 100895 - Kazal-type serine protease inhibitors 100895 - Kazal-type serine protease inhibitors	0	DIRECT
53098,56672 53098 - Ribonuclease H-like 56672 - DNA/RNA polymerases	0	DIRECT
74924,74924 74924 - Cap-Gly domain 74924 - Cap-Gly domain	0	DIRECT
57184,49899 57184 - Growth factor receptor domain 49899 - Concanavalin A-like lectins/glucanases	0	DIRECT
49742,49742 49742 - PHM/PNGase F 49742 - PHM/PNGase F	0	DIRECT
54236,50729 54236 - Ubiquitin-like 50729 - PH domain-like	0	DIRECT
57414,57440 57414 - Hairpin loop containing domain-like 57440 - Kringle-like	0	DIRECT
81811,82754 81811 - Helical domain of Sec23/24 82754 - C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
52540,47917 52540 - P-loop containing nucleoside triphosphate hydrolases 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
102712,-7 102712 - JAB1/MPN domain -7 - CATH	0	DIRECT
49417,55550 49417 - p53-like transcription factors 55550 - SH2 domain	0	DIRECT
54637,54637 54637 - Thioesterase/thiol ester dehydrase-isomerase 54637 - Thioesterase/thiol ester dehydrase-isomerase	0	DIRECT
54826,51604 54826 - Enolase N-terminal domain-like 51604 - Enolase C-terminal domain-like	0	DIRECT
51230,47005 51230 - Single hybrid motif 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	DIRECT
51445,51445 51445 - (Trans)glycosidases 51445 - (Trans)glycosidases	0	DIRECT
110324,50249 110324 - Ribosomal L27 protein-like 50249 - Nucleic acid-binding proteins	0	DIRECT
53850,53850 53850 - Periplasmic binding protein-like II 53850 - Periplasmic binding protein-like II	0	DIRECT
52540,51045 52540 - P-loop containing nucleoside triphosphate hydrolases 51045 - WW domain	0	DIRECT
48371,-7 48371 - ARM repeat -7 - CATH	0	DIRECT
64268,49562 64268 - PX domain 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)	0	DIRECT
56112,64268 56112 - Protein kinase-like (PK-like) 64268 - PX domain	0	DIRECT
53300,57184 53300 - vWA-like 57184 - Growth factor receptor domain	0	DIRECT
56091,50249 56091 - DNA ligase/mRNA capping enzyme, catalytic domain 50249 - Nucleic acid-binding proteins	0	DIRECT
57924,57924 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat	0	DIRECT
117839,56399 117839 - WWE domain 56399 - ADP-ribosylation	0	DIRECT
57196,69687 57196 - EGF/Laminin 69687 - Integrin beta tail domain	0	DIRECT
50156,52540 50156 - PDZ domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
81698,81698 81698 - FF domain 81698 - FF domain	0	DIRECT
57889,49562 57889 - Cysteine-rich domain 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)	0	DIRECT
52540,-7 52540 - P-loop containing nucleoside triphosphate hydrolases -7 - CATH	0	DIRECT
47655,49417 47655 - STAT 49417 - p53-like transcription factors	0	DIRECT
47473,57610 47473 - EF-hand 57610 - Thyroglobulin type-1 domain	0	DIRECT
57889,48350 57889 - Cysteine-rich domain 48350 - GTPase activation domain, GAP	0	DIRECT
56672,100879 56672 - DNA/RNA polymerases 100879 - Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
57850,88697 57850 - RING/U-box 88697 - PUA domain-like	0	DIRECT
53300,49899 53300 - vWA-like 49899 - Concanavalin A-like lectins/glucanases	0	DIRECT
53738,55957 53738 - Phosphoglucomutase, first 3 domains 55957 - Phosphoglucomutase, C-terminal domain	0	DIRECT
56059,51246 56059 - Glutathione synthetase ATP-binding domain-like 51246 - Rudiment single hybrid motif	0	DIRECT
100950,100950 100950 - NagB/RpiA/CoA transferase-like 100950 - NagB/RpiA/CoA transferase-like	0	DIRECT
53300,49265 53300 - vWA-like 49265 - Fibronectin type III	0	DIRECT
57756,57756 57756 - Retrovirus zinc finger-like domains 57756 - Retrovirus zinc finger-like domains	0	DIRECT
48350,55961 48350 - GTPase activation domain, GAP 55961 - Bet v1-like	0	DIRECT
47203,47203 47203 - Acyl-CoA dehydrogenase C-terminal domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like	0	DIRECT
47986,47986 47986 - DEATH domain 47986 - DEATH domain	0	DIRECT
49899,48726 49899 - Concanavalin A-like lectins/glucanases 48726 - Immunoglobulin	0	DIRECT
117018,56091 117018 - ATP-dependent DNA ligase DNA-binding domain 56091 - DNA ligase/mRNA capping enzyme, catalytic domain	0	DIRECT
49695,50370 49695 - gamma-Crystallin-like 50370 - Ricin B-like lectins	0	DIRECT
49599,49599 49599 - TRAF domain-like 49599 - TRAF domain-like	0	DIRECT
50447,-8 50447 - Translation proteins -8 - ECOD	0	DIRECT
52113,52113 52113 - BRCT domain 52113 - BRCT domain	0	DIRECT
50677,52374 50677 - ValRS/IleRS/LeuRS editing domain 52374 - Nucleotidylyl transferase	0	DIRECT
49417,81296 49417 - p53-like transcription factors 81296 - E set domains	0	DIRECT
57850,48452 57850 - RING/U-box 48452 - TPR-like	0	DIRECT
53328,50486 53328 - Formyltransferase 50486 - FMT C-terminal domain-like	0	DIRECT
47986,52129 47986 - DEATH domain 52129 - Caspase-like	0	DIRECT
49265,53300 49265 - Fibronectin type III 53300 - vWA-like	0	DIRECT
49899,63887 49899 - Concanavalin A-like lectins/glucanases 63887 - P-domain of calnexin/calreticulin	0	DIRECT
57716,48508 57716 - Glucocorticoid receptor-like (DNA-binding domain) 48508 - Nuclear receptor ligand-binding domain	0.002837	INHERITED FROM: diisononyl 1,2-cyclohexanedicarboxylic acid || Cyclopentanes || Ethers, Cyclic || Cyclohexenes || Bexarotene || Lactams, Macrocyclic || 2,2-bis(4-glycidyloxyphenyl)propane || SR 11237 || Cyclohexanones || Cycloparaffins || 1,1-bis(4-hydroxyphenyl)cyclohexane || Trichothecenes || 3-acetyldeoxynivalenol || Cyclohexanecarboxylic Acids || Permethrin || Retinoids || Ciclopirox || resmethrin || cyhalothrin || Rifamycins || Alitretinoin || Pyrethrins || Vitamin A || Polyketides || Carotenoids || Fenretinide || Cyclopentane Monoterpenes || 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid || Tretinoin || fenvalerate
57586,57586 57586 - TNF receptor-like 57586 - TNF receptor-like	0.006185	INHERITED FROM: Cyclohexanols || Epoxy Compounds || Cyclohexanes || Menthol || Nystatin || Paclitaxel || Cyclohexane Monoterpenes || Cycloparaffins || 4-(3-(1-adamantyl)-4-hydroxyphenyl)-3-chlorocinnamic acid
69179,69179 69179 - Integrin domains 69179 - Integrin domains	0.008377	INHERITED FROM: Cyclohexanes || Cyclohexenes || Retinoids
69318,69179 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains	0.008377	INHERITED FROM: Cyclohexanes || Cyclohexenes || Retinoids
54001,49758 54001 - Cysteine proteinases 49758 - Calpain large subunit, middle domain (domain III)	0.01112	INHERITED FROM: Cyclohexanols || Epoxy Compounds || Menthol || Cyclohexane Monoterpenes || glycidamide
57850,49599 57850 - RING/U-box 49599 - TRAF domain-like	0.01112	INHERITED FROM: Menthol || Cyclohexane Monoterpenes
47454,57959 47454 - A DNA-binding domain in eukaryotic transcription factors 57959 - Leucine zipper domain	0.02397	INHERITED FROM: Epoxy Compounds || Cyclohexenes || Tetrapyrroles || Rifampin || Trichothecenes || Retinoids || deoxynivalenol || Vitamin A || Hemin || Tretinoin
52799,52799 52799 - (Phosphotyrosine protein) phosphatases II 52799 - (Phosphotyrosine protein) phosphatases II	0.02742	INHERITED FROM: Cyclohexanes || Cyclohexenes || Cycloparaffins || Retinoids || Carotenoids
49758,47473 49758 - Calpain large subunit, middle domain (domain III) 47473 - EF-hand	0.0386	INHERITED FROM: Menthol || Cyclohexane Monoterpenes
50129,51735 50129 - GroES-like 51735 - NAD(P)-binding Rossmann-fold domains	0.04046	INHERITED FROM: apocarotenal
63737,55486 63737 - Leukotriene A4 hydrolase N-terminal domain 55486 - Metalloproteases ("zincins"), catalytic domain	0.04829	INHERITED FROM: Peptides, Cyclic || Cyclosporins
47954,47954 47954 - Cyclin-like 47954 - Cyclin-like	0.05754	INHERITED FROM: Cyclodecanes || apicidin || Paclitaxel || Polyketides || 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid || triptolide
52821,52799 52821 - Rhodanese/Cell cycle control phosphatase 52799 - (Phosphotyrosine protein) phosphatases II	0.06393	INHERITED FROM: Epoxy Compounds || Trichothecenes || glycidamide
54849,52029 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like	0.06771	INHERITED FROM: Okadaic Acid || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Adamantane || Ivermectin || CD 437
52833,52833 52833 - Thioredoxin-like 52833 - Thioredoxin-like	0.08218	INHERITED FROM: Cycloheptanes || Sesquiterpenes, Guaiane || Thapsigargin || Cyclosporins
52058,57184 52058 - L domain-like 57184 - Growth factor receptor domain	0.08498	INHERITED FROM: Cyclopentanes || Cyclodecanes || Paclitaxel || Polyketides
57184,52058 57184 - Growth factor receptor domain 52058 - L domain-like	0.08498	INHERITED FROM: Cyclopentanes || Cyclodecanes || Paclitaxel || Polyketides
57184,57184 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain	0.08704	INHERITED FROM: Chlorogenic Acid || Cyclohexenes || Paclitaxel || Cycloparaffins || Retinoids
48592,54849 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like	0.09385	INHERITED FROM: Okadaic Acid || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Adamantane || Ivermectin || CD 437
57440,50494 57440 - Kringle-like 50494 - Trypsin-like serine proteases	0.1098	INHERITED FROM: Dactinomycin
53901,53901 53901 - Thiolase-like 53901 - Thiolase-like	0.1098	INHERITED FROM: Isotretinoin
54928,54928 54928 - RNA-binding domain, RBD 54928 - RNA-binding domain, RBD	0.1148	INHERITED FROM: 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol
54452,48726 54452 - MHC antigen-recognition domain 48726 - Immunoglobulin	0.1387	INHERITED FROM: Isotretinoin || Erythromycin
49785,49785 49785 - Galactose-binding domain-like 49785 - Galactose-binding domain-like	0.1427	INHERITED FROM: Menthol
100895,47473 100895 - Kazal-type serine protease inhibitors 47473 - EF-hand	0.1427	INHERITED FROM: Paclitaxel || Taxoids
50729,56112 50729 - PH domain-like 56112 - Protein kinase-like (PK-like)	0.1427	INHERITED FROM: Cyclopentanes || Cyclodecanes || geldanamycin || Menthol || Cyclohexane Monoterpenes || Macrolides || Sirolimus || Metalloporphyrins
52833,47616 52833 - Thioredoxin-like 47616 - GST C-terminal domain-like	0.1594	INHERITED FROM: Cyclohexanes || Okadaic Acid || Tetrapyrroles || apple polyphenol extract || Microcystins || Bile Pigments || microcystin RR || apocarotenal || beta Carotene
90123,52540 90123 - ABC transporter transmembrane region 52540 - P-loop containing nucleoside triphosphate hydrolases	0.1594	INHERITED FROM: Docetaxel || Cyclodecanes || Lactams, Macrocyclic || Rifampin || Cycloparaffins || Taxoids || Rifamycins || Dactinomycin
46785,144074 46785 - "Winged helix" DNA-binding domain 144074 - E2F-DP heterodimerization region	0.1735	INHERITED FROM: Cyclohexanols || Menthol || Paclitaxel || Cyclohexane Monoterpenes
52490,55307 52490 - Tubulin nucleotide-binding domain-like 55307 - Tubulin C-terminal domain-like	0.204	INHERITED FROM: Cycloheptanes || Sesquiterpenes, Guaiane || Thapsigargin || 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol
55550,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like)	0.2154	INHERITED FROM: 4-acetylantroquinonol B || Cyclohexanones
57184,63825 57184 - Growth factor receptor domain 63825 - YWTD domain	0.2389	INHERITED FROM: Cycloheptanes || Sesquiterpenes, Guaiane || Thapsigargin
57440,57440 57440 - Kringle-like 57440 - Kringle-like	0.2564	INHERITED FROM: Isotretinoin || Lactams, Macrocyclic || Tetrapyrroles || Porphyrins || Paclitaxel || Cyclohexanecarboxylic Acids || Alitretinoin || Dactinomycin
63411,63411 63411 - LuxS/MPP-like metallohydrolase 63411 - LuxS/MPP-like metallohydrolase	0.3058	INHERITED FROM: Isotretinoin
47090,55486 47090 - PGBD-like 55486 - Metalloproteases ("zincins"), catalytic domain	0.3193	INHERITED FROM: Chlorogenic Acid || Cyclodecanes || Tetrapyrroles || Porphyrins || 3-caffeoyl-4-dihydrocaffeoylquinic acid || Paclitaxel || manganese(III)-tetrakis(4-benzoic acid)porphyrin || cyclo(Trp-Asp-Pro-Val-Leu) || Cyclohexanecarboxylic Acids
46579,64593 46579 - Prefoldin 64593 - Intermediate filament protein, coiled coil region	0.3226	INHERITED FROM: Isotretinoin || 4-oxoretinol || Bexarotene || 4-oxoretinoic acid || Alitretinoin || beta Carotene || ethyl-p-((E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-1-propenyl)benzoic acid
53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain	0.3391	INHERITED FROM: Thiostrepton || yessotoxin || Ivermectin || Hemin || aurin
52540,90123 52540 - P-loop containing nucleoside triphosphate hydrolases 90123 - ABC transporter transmembrane region	0.3492	INHERITED FROM: Docetaxel || Cyclodecanes || Lactams, Macrocyclic || Rifampin || Taxoids || Rifamycins
55486,50923 55486 - Metalloproteases ("zincins"), catalytic domain 50923 - Hemopexin-like domain	0.3671	INHERITED FROM: Paclitaxel || manganese(III)-tetrakis(4-benzoic acid)porphyrin || Metalloporphyrins || cobaltiprotoporphyrin
47459,55785 47459 - HLH, helix-loop-helix DNA-binding domain 55785 - PYP-like sensor domain (PAS domain)	0.3671	INHERITED FROM: Cyclopentanes || Lactams, Macrocyclic || Okadaic Acid || Rifampin || Rifamycins || Polyketides
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin	0.3986	INHERITED FROM: Cyclohexenes || Cycloparaffins
55785,55785 55785 - PYP-like sensor domain (PAS domain) 55785 - PYP-like sensor domain (PAS domain)	0.4183	INHERITED FROM: Cyclopentanes || Lactams, Macrocyclic || Rifampin || Macrolides || Rifamycins || Polyketides
57889,57889 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain	0.4659	INHERITED FROM: Macrolides || Bryostatins || Polyketides
103473,100895 103473 - MFS general substrate transporter 100895 - Kazal-type serine protease inhibitors	0.4773	INHERITED FROM: Lactams, Macrocyclic || Rifampin || Rifamycins
56112,56112 56112 - Protein kinase-like (PK-like) 56112 - Protein kinase-like (PK-like)	0.4847	INHERITED FROM: Lycopene
52518,52922 52518 - Thiamin diphosphate-binding fold (THDP-binding) 52922 - TK C-terminal domain-like	0.5069	INHERITED FROM: Isotretinoin
53300,53300 53300 - vWA-like 53300 - vWA-like	0.5561	INHERITED FROM: Paclitaxel || Taxoids
47459,158457 47459 - HLH, helix-loop-helix DNA-binding domain 158457 - Orange domain-like	0.631	INHERITED FROM: Cycloheptanes || Sesquiterpenes, Guaiane || Thapsigargin
64593,64593 64593 - Intermediate filament protein, coiled coil region 64593 - Intermediate filament protein, coiled coil region	0.989	INHERITED FROM: 4-oxoretinoic acid || Alitretinoin || beta Carotene || ethyl-p-((E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-1-propenyl)benzoic acid
63712,90112 63712 - Nicotinic receptor ligand binding domain-like 90112 - Neurotransmitter-gated ion-channel transmembrane pore	0.9921	INHERITED FROM: Picrotoxin || menthone || carvone
49313,49313 49313 - Cadherin-like 49313 - Cadherin-like	1	INHERITED FROM: jasplakinolide

Supra-domain (Triple) in N- to C-terminal order

Highlighted in gray are those with FDR>0.001

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
46689,46689,46689 46689 - Homeodomain-like 46689 - Homeodomain-like 46689 - Homeodomain-like	0	DIRECT
57603,57603,57603 57603 - FnI-like domain 57603 - FnI-like domain 57603 - FnI-like domain	0	DIRECT
52743,49785,57184 52743 - Subtilisin-like 49785 - Galactose-binding domain-like 57184 - Growth factor receptor domain	0	DIRECT
57889,57889,49562 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)	0	DIRECT
49562,57889,57889 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain	0	DIRECT
52540,52540,46785 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 46785 - "Winged helix" DNA-binding domain	0	DIRECT
53067,53067,100920 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
50447,-8,54980 50447 - Translation proteins -8 - ECOD 54980 - EF-G C-terminal domain-like	0	DIRECT
57196,57184,49899 57196 - EGF/Laminin 57184 - Growth factor receptor domain 49899 - Concanavalin A-like lectins/glucanases	0	DIRECT
53067,53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain	0	DIRECT
50729,50729,57863 50729 - PH domain-like 50729 - PH domain-like 57863 - ArfGap/RecO-like zinc finger	0	DIRECT
48452,57850,88697 48452 - TPR-like 57850 - RING/U-box 88697 - PUA domain-like	0	DIRECT
100895,47473,57610 100895 - Kazal-type serine protease inhibitors 47473 - EF-hand 57610 - Thyroglobulin type-1 domain	0	DIRECT
117018,56091,50249 117018 - ATP-dependent DNA ligase DNA-binding domain 56091 - DNA ligase/mRNA capping enzyme, catalytic domain 50249 - Nucleic acid-binding proteins	0	DIRECT
50729,50729,48350 50729 - PH domain-like 50729 - PH domain-like 48350 - GTPase activation domain, GAP	0	DIRECT
47655,49417,55550 47655 - STAT 49417 - p53-like transcription factors 55550 - SH2 domain	0	DIRECT
51045,47473,47473 51045 - WW domain 47473 - EF-hand 47473 - EF-hand	0	DIRECT
81995,81811,82754 81995 - beta-sandwich domain of Sec23/24 81811 - Helical domain of Sec23/24 82754 - C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
52540,51045,51045 52540 - P-loop containing nucleoside triphosphate hydrolases 51045 - WW domain 51045 - WW domain	0	DIRECT
56645,47203,47203 56645 - Acyl-CoA dehydrogenase NM domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like	0	DIRECT
57184,100895,48726 57184 - Growth factor receptor domain 100895 - Kazal-type serine protease inhibitors 48726 - Immunoglobulin	0	DIRECT
52440,56059,51246 52440 - PreATP-grasp domain 56059 - Glutathione synthetase ATP-binding domain-like 51246 - Rudiment single hybrid motif	0	DIRECT
48371,56112,64268 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) 64268 - PX domain	0	DIRECT
57196,57535,57535 57196 - EGF/Laminin 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain	0	DIRECT
90188,90188,53649 90188 - Somatomedin B domain 90188 - Somatomedin B domain 53649 - Alkaline phosphatase-like	0	DIRECT
51230,47005,52777 51230 - Single hybrid motif 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex 52777 - CoA-dependent acyltransferases	0	DIRECT
54416,54416,49998 54416 - Amine oxidase N-terminal region 54416 - Amine oxidase N-terminal region 49998 - Amine oxidase catalytic domain	0	DIRECT
57924,57924,57924 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat	0	DIRECT
50156,52540,51045 50156 - PDZ domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases 51045 - WW domain	0	DIRECT
46966,46966,51045 46966 - Spectrin repeat 46966 - Spectrin repeat 51045 - WW domain	0	DIRECT
53067,100920,100934 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
57184,49899,49899 57184 - Growth factor receptor domain 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases	0	DIRECT
81698,81698,81698 81698 - FF domain 81698 - FF domain 81698 - FF domain	0	DIRECT
56112,64268,49562 56112 - Protein kinase-like (PK-like) 64268 - PX domain 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)	0	DIRECT
100895,100895,100895 100895 - Kazal-type serine protease inhibitors 100895 - Kazal-type serine protease inhibitors 100895 - Kazal-type serine protease inhibitors	0	DIRECT
57196,57196,69687 57196 - EGF/Laminin 57196 - EGF/Laminin 69687 - Integrin beta tail domain	0	DIRECT
49899,48726,49265 49899 - Concanavalin A-like lectins/glucanases 48726 - Immunoglobulin 49265 - Fibronectin type III	0	DIRECT
50249,50249,50249 50249 - Nucleic acid-binding proteins 50249 - Nucleic acid-binding proteins 50249 - Nucleic acid-binding proteins	0	DIRECT
53300,81995,81811 53300 - vWA-like 81995 - beta-sandwich domain of Sec23/24 81811 - Helical domain of Sec23/24	0	DIRECT
57184,52058,57184 57184 - Growth factor receptor domain 52058 - L domain-like 57184 - Growth factor receptor domain	0	DIRECT
55753,55753,47050 55753 - Actin depolymerizing proteins 55753 - Actin depolymerizing proteins 47050 - VHP, Villin headpiece domain	0	DIRECT
57414,57440,57440 57414 - Hairpin loop containing domain-like 57440 - Kringle-like 57440 - Kringle-like	0	DIRECT
57850,49599,49599 57850 - RING/U-box 49599 - TRAF domain-like 49599 - TRAF domain-like	0	DIRECT
47986,47986,52129 47986 - DEATH domain 47986 - DEATH domain 52129 - Caspase-like	0	DIRECT
57630,57196,50494 57630 - GLA-domain 57196 - EGF/Laminin 50494 - Trypsin-like serine proteases	0	DIRECT
57850,48452,57850 57850 - RING/U-box 48452 - TPR-like 57850 - RING/U-box	0	DIRECT
49265,49265,53300 49265 - Fibronectin type III 49265 - Fibronectin type III 53300 - vWA-like	0	DIRECT
49265,48726,48726 49265 - Fibronectin type III 48726 - Immunoglobulin 48726 - Immunoglobulin	0	DIRECT
57586,57586,57586 57586 - TNF receptor-like 57586 - TNF receptor-like 57586 - TNF receptor-like	0	DIRECT
57196,57581,57196 57196 - EGF/Laminin 57581 - TB module/8-cys domain 57196 - EGF/Laminin	0	DIRECT
48092,47655,49417 48092 - Transcription factor STAT-4 N-domain 47655 - STAT 49417 - p53-like transcription factors	0	DIRECT
46966,51045,47473 46966 - Spectrin repeat 51045 - WW domain 47473 - EF-hand	0	DIRECT
53738,53738,55957 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains 55957 - Phosphoglucomutase, C-terminal domain	0	DIRECT
63763,57903,47370 63763 - SAND domain-like 57903 - FYVE/PHD zinc finger 47370 - Bromodomain	0	DIRECT
49503,49503,49503 49503 - Cupredoxins 49503 - Cupredoxins 49503 - Cupredoxins	0	DIRECT
48726,49265,56112 48726 - Immunoglobulin 49265 - Fibronectin type III 56112 - Protein kinase-like (PK-like)	0	DIRECT
48552,48552,48552 48552 - Serum albumin-like 48552 - Serum albumin-like 48552 - Serum albumin-like	0	DIRECT
53738,53738,53738 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains	0	DIRECT
69318,69179,69179 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains 69179 - Integrin domains	0.008377	INHERITED FROM: Cyclohexanes || Cyclohexenes || Retinoids
69179,69179,69179 69179 - Integrin domains 69179 - Integrin domains 69179 - Integrin domains	0.01528	INHERITED FROM: Cyclohexanes || Cyclohexenes || Retinoids
54001,49758,47473 54001 - Cysteine proteinases 49758 - Calpain large subunit, middle domain (domain III) 47473 - EF-hand	0.0576	INHERITED FROM: Cyclohexanols || Menthol || Cyclohexane Monoterpenes
52058,57184,52058 52058 - L domain-like 57184 - Growth factor receptor domain 52058 - L domain-like	0.08498	INHERITED FROM: Cyclopentanes || Cyclodecanes || Paclitaxel || Polyketides
48592,54849,52029 48592 - GroEL equatorial domain-like 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like	0.09385	INHERITED FROM: Okadaic Acid || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Adamantane || Ivermectin || CD 437
52833,52833,52833 52833 - Thioredoxin-like 52833 - Thioredoxin-like 52833 - Thioredoxin-like	0.1282	INHERITED FROM: Cycloheptanes || Sesquiterpenes, Guaiane || Thapsigargin
46966,46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat 46966 - Spectrin repeat	0.1555	INHERITED FROM: Vitamin A || Tretinoin
57184,57184,57196 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain 57196 - EGF/Laminin	0.1851	INHERITED FROM: Cyclodecanes || Paclitaxel
57440,57440,57440 57440 - Kringle-like 57440 - Kringle-like 57440 - Kringle-like	0.3058	INHERITED FROM: Isotretinoin
90123,52540,90123 90123 - ABC transporter transmembrane region 52540 - P-loop containing nucleoside triphosphate hydrolases 90123 - ABC transporter transmembrane region	0.3492	INHERITED FROM: Docetaxel || Cyclodecanes || Lactams, Macrocyclic || Rifampin || Taxoids || Rifamycins
52540,90123,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 90123 - ABC transporter transmembrane region 52540 - P-loop containing nucleoside triphosphate hydrolases	0.3492	INHERITED FROM: Docetaxel || Cyclodecanes || Lactams, Macrocyclic || Rifampin || Taxoids || Rifamycins
47459,55785,55785 47459 - HLH, helix-loop-helix DNA-binding domain 55785 - PYP-like sensor domain (PAS domain) 55785 - PYP-like sensor domain (PAS domain)	0.4183	INHERITED FROM: Cyclopentanes || Lactams, Macrocyclic || Rifampin || Paclitaxel || Macrolides || Rifamycins || Polyketides
57196,57196,57184 57196 - EGF/Laminin 57196 - EGF/Laminin 57184 - Growth factor receptor domain	0.4633	INHERITED FROM: Cyclohexenes || Cycloparaffins || Retinoids
47090,55486,50923 47090 - PGBD-like 55486 - Metalloproteases ("zincins"), catalytic domain 50923 - Hemopexin-like domain	0.4734	INHERITED FROM: Tetrapyrroles || Paclitaxel || manganese(III)-tetrakis(4-benzoic acid)porphyrin || Metalloporphyrins || cobaltiprotoporphyrin
49899,49899,49899 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases	0.687	INHERITED FROM: Vitamin A || Tretinoin
57196,57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin 57196 - EGF/Laminin	0.693	INHERITED FROM: Cyclohexanes || Cyclohexenes || Retinoids
49313,49313,49313 49313 - Cadherin-like 49313 - Cadherin-like 49313 - Cadherin-like	1	INHERITED FROM: jasplakinolide