Ras GEF superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All alpha proteins [ 46456] (284)
• Fold: Ras GEF [ 48365]
• Superfamily: Ras GEF [ 48366]
• Families: Ras GEF [ 48367]

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Superfamily statistics

	Genomes (408)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	5,754	17,240	6
Proteins	5,544	16,804	6

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Functional annotation

• General category: Regulation
• Detailed category: Signal transduction

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of fluid regulation	0.0004556	1.503	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal homeostasis	0.01893	0.7631	--	INHERITED FROM: Abnormality of fluid regulation || Edema
Phenotypic Abnormality (PA)	Abnormality of metabolism/homeostasis	0.09744	0.5315	Least Informative	INHERITED FROM: Abnormality of fluid regulation || Edema
Phenotypic Abnormality (PA)	Abnormality of blood and blood-forming tissues	0.01424	1.026	Moderately Informative	INHERITED FROM: Abnormal thrombocyte morphology || Abnormal bleeding
Phenotypic Abnormality (PA)	Abnormal thrombocyte morphology	0.0001187	1.561	Informative	DIRECT
Phenotypic Abnormality (PA)	Edema	0.0002238	1.503	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal bleeding	0.0002545	1.503	Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal cell physiology	0.3969	0.6214	--	INHERITED FROM: abnormal cell adhesion
Mammalian Phenotype (MP)	cellular phenotype	0.5508	0.5301	Least Informative	INHERITED FROM: abnormal cell adhesion
Mammalian Phenotype (MP)	abnormal cell adhesion	0.0006339	1.906	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.07108	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.01121	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.08329	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001706	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.06117	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.004279	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.2011	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.05921	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.07209	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.171	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1685	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.06709	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.1278	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1672	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.09267	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || reproductive system physiology variant || lethal || development variant || hermaphrodite sterile || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || fertility variant || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.161	--	INHERITED FROM: hermaphrodite sterile || maternal sterile

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.1328	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0	0.2018	--	DIRECT
Yeast Phenotype (YP)	competitive fitness	0	0.1389	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1328	--	DIRECT
Yeast Phenotype (YP)	resistance to chemicals	0	0.4182	Least Informative	DIRECT
Yeast Phenotype (YP)	metabolism and growth	0	0.5905	Least Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.004764	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.2245	--	DIRECT
Zebrafish Anatomy (ZA)	cavitated compound organ	0	0.5472	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1889	--	DIRECT
Zebrafish Anatomy (ZA)	pronephric glomerulus	0.00001514	2.439	--	DIRECT
Zebrafish Anatomy (ZA)	renal system	0.0009604	2.439	--	DIRECT
Zebrafish Anatomy (ZA)	pronephros	0.001245	2.439	--	INHERITED FROM: pronephric glomerulus
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: renal system || anatomical system || multi-tissue structure || anatomical cluster || pronephric glomerulus || anatomical group || whole organism || compound organ || cavitated compound organ
Zebrafish Anatomy (ZA)	compound organ	0	0.4571	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	multi-tissue structure	0	0.6005	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	anatomical cluster	0	0.883	Moderately Informative	DIRECT
Zebrafish Anatomy (ZA)	pleuroperitoneal region	0.04713	1.661	Informative	INHERITED FROM: pronephric glomerulus

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1871	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.193	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1217	--	DIRECT
Xenopus ANatomical entity (XAN)	retinal outer plexiform layer	0.0001565	2.761	--	DIRECT
Xenopus ANatomical entity (XAN)	retinal inner plexiform layer	0.0003479	2.284	--	DIRECT
Xenopus ANatomical entity (XAN)	retina	0.04224	1.807	--	INHERITED FROM: retinal outer plexiform layer || retinal inner plexiform layer
Xenopus ANatomical entity (XAN)	central nervous system	0.1012	0.6506	--	INHERITED FROM: retinal outer plexiform layer || retinal inner plexiform layer
Xenopus ANatomical entity (XAN)	visual system	0.1638	1.363	--	INHERITED FROM: retinal outer plexiform layer || retinal inner plexiform layer
Xenopus ANatomical entity (XAN)	head region	0.2745	0.5108	--	INHERITED FROM: retinal outer plexiform layer || retinal inner plexiform layer
Xenopus ANatomical entity (XAN)	anatomical group	0.5343	0.1442	--	INHERITED FROM: retinal inner plexiform layer || retinal outer plexiform layer
Xenopus ANatomical entity (XAN)	compound organ	0.535	0.24	--	INHERITED FROM: retinal outer plexiform layer || retinal inner plexiform layer
Xenopus ANatomical entity (XAN)	anatomical system	1	0.3094	--	INHERITED FROM: retinal inner plexiform layer || retinal outer plexiform layer
Xenopus ANatomical entity (XAN)	whole organism	1	0.09747	--	INHERITED FROM: multicellular anatomical structure || anatomical region || retinal inner plexiform layer || organism subdivision || retinal outer plexiform layer
Xenopus ANatomical entity (XAN)	nervous system	0.1088	0.6341	Least Informative	INHERITED FROM: retinal outer plexiform layer || retinal inner plexiform layer
Xenopus ANatomical entity (XAN)	cavitated compound organ	0.1854	0.3033	Least Informative	INHERITED FROM: retinal outer plexiform layer || retinal inner plexiform layer
Xenopus ANatomical entity (XAN)	head	0.2415	0.5108	Least Informative	INHERITED FROM: retinal inner plexiform layer || retinal outer plexiform layer
Xenopus ANatomical entity (XAN)	tissue	1	0.5011	Least Informative	INHERITED FROM: retinal inner plexiform layer || retinal outer plexiform layer
Xenopus ANatomical entity (XAN)	sensory system	0.2291	1.17	Moderately Informative	INHERITED FROM: retinal outer plexiform layer || retinal inner plexiform layer
Xenopus ANatomical entity (XAN)	multi-tissue structure	0.3293	1.071	Moderately Informative	INHERITED FROM: retinal outer plexiform layer || retinal inner plexiform layer
Xenopus ANatomical entity (XAN)	eye	0.1977	1.399	Informative	INHERITED FROM: retinal inner plexiform layer || retinal outer plexiform layer
Xenopus ANatomical entity (XAN)	retinal neural layer	0.02648	1.983	Highly Informative	INHERITED FROM: retinal inner plexiform layer || retinal outer plexiform layer
Xenopus DEvelopment stage (XDE)	NF stage	0	0.02327	--	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Acting on ester bonds	0.000006804	0.7559	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0.002281	0.3541	Least Informative	INHERITED FROM: Acting on ester bonds || Phosphoric diester hydrolases || Phosphoinositide phospholipase C
Enzyme Commission (EC)	Phosphoric diester hydrolases	0.0000000000008941	1.46	Informative	DIRECT
Enzyme Commission (EC)	Phosphoinositide phospholipase C	0	1.998	Highly Informative	DIRECT

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InterPro annotation

• Cross references: IPR008937 SSF48366 Protein matches
• Abstract:

  Small GTPases of the Ras family alternate between 2 conformations induced by the binding of either GTP or GDP. Guanine nucleotide exchange factors (GEFs) induce the dissociation of GDP to allow association of the more abundant GTP. The Ras-like family of small GTPases includes, among others, Ras, Rap1, R-ras, and Ral. The family is characterised by similarities in the effector domain. The Ras GTPase Rap1 is activated rapidly in response to activation of a variety of receptors. Rap1 activation is mediated by several second messengers, including calcium, diacylglycerol, and cAMP. GEFs have been identified that mediate these effects. One such GEF is Epac, an exchange protein directly activated by cAMP, which represents a novel cAMP-induced, protein kinase A-independent pathway [10579920].

InterPro database

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