beta-Lactamase/D-ala carboxypeptidase family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Multi-domain proteins (alpha and beta) [ 56572] (66)
• Fold: beta-lactamase/transpeptidase-like [ 56600]
• Superfamily: beta-lactamase/transpeptidase-like [ 56601] (3)
• Family: beta-Lactamase/D-ala carboxypeptidase [ 56602] (18)

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Family statistics

	Genomes (2,144)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	8,824	91,032	106
Proteins	8,816	90,941	106

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Serine-type D-Ala-D-Ala carboxypeptidase	0	2.264	--	DIRECT
Enzyme Commission (EC)	D-stereospecific aminopeptidase	0	2.44	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.01852	--	DIRECT
Enzyme Commission (EC)	Peptidoglycan glycosyltransferase	0	2.264	--	DIRECT
Enzyme Commission (EC)	Beta-lactamase	0	2.264	--	DIRECT
Enzyme Commission (EC)	Transferases	1	0	--	INHERITED FROM: Glycosyltransferases || Peptidoglycan glycosyltransferase || Hexosyltransferases
Enzyme Commission (EC)	Acting on peptide bonds (peptide hydrolases)	0.3536	0.5709	Least Informative	INHERITED FROM: Serine-type D-Ala-D-Ala carboxypeptidase || Serine-type carboxypeptidases || D-stereospecific aminopeptidase || Aminopeptidases
Enzyme Commission (EC)	Acting on carbon-nitrogen bonds, other than peptid	0	0.8435	Moderately Informative	DIRECT
Enzyme Commission (EC)	Glycosyltransferases	0.0004205	0.993	Moderately Informative	DIRECT
Enzyme Commission (EC)	In cyclic amides	0	1.627	Informative	DIRECT
Enzyme Commission (EC)	Hexosyltransferases	0.000000002196	1.264	Informative	DIRECT
Enzyme Commission (EC)	Aminopeptidases	0.0002041	1.627	Informative	DIRECT
Enzyme Commission (EC)	Serine-type carboxypeptidases	0.0000000000000375	2.139	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	larval growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	growth variant	0	0.3438	--	DIRECT
Worm Phenotype (WP)	larval development variant	0	0.4322	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	developmental growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	basement membrane remodeling variant	0.00001187	1.225	--	DIRECT
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: pericellular component development variant || hermaphrodite fertility variant || developmental growth variant || reproductive system physiology variant || organism homeostasis metabolism variant || lethal || larval development variant || basement membrane remodeling variant || organism physiology variant || development variant || hermaphrodite sterile || growth variant || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || larval growth variant || fertility variant || postembryonic development variant || larval arrest || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	larval arrest	0	0.4991	Least Informative	DIRECT
Worm Phenotype (WP)	pericellular component development variant	0.00003761	1.178	Moderately Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	D-stereospecific aminopeptidase	0	2.929	--	DIRECT
Enzyme Commission (EC)	Hexosyltransferases	0	1.65	--	DIRECT
Enzyme Commission (EC)	Beta-lactamase	0	2.753	--	DIRECT
Enzyme Commission (EC)	Peptidoglycan glycosyltransferase	0	2.929	--	DIRECT
Enzyme Commission (EC)	Serine-type carboxypeptidases	0	2.452	--	DIRECT
Enzyme Commission (EC)	Serine-type D-Ala-D-Ala carboxypeptidase	0	2.531	--	DIRECT
Enzyme Commission (EC)	Teichoic acid D-alanine hydrolase	0.000000000009186	3.23	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.4043	Least Informative	DIRECT
Enzyme Commission (EC)	Transferases	1	0.3972	Least Informative	INHERITED FROM: Peptidoglycan glycosyltransferase || Glycosyltransferases || Hexosyltransferases
Enzyme Commission (EC)	Acting on peptide bonds (peptidases)	0	1.004	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on carbon-nitrogen bonds, other than peptide bonds	0	1.213	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	1	0.8756	Moderately Informative	INHERITED FROM: Teichoic acid D-alanine hydrolase
Enzyme Commission (EC)	Glycosyltransferases	0	1.378	Informative	DIRECT
Enzyme Commission (EC)	Carboxylic ester hydrolases	0.3915	1.539	Informative	INHERITED FROM: Teichoic acid D-alanine hydrolase
Enzyme Commission (EC)	In cyclic amides	0	2.026	Highly Informative	DIRECT
Enzyme Commission (EC)	Aminopeptidases	0.9304	2.054	Highly Informative	INHERITED FROM: D-stereospecific aminopeptidase

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