Acting on the CH-OH group of donors

Enzyme Commission (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed. To navigate hierarchical structure of EC, we display all parental EC terms to the current EC term of interest ordered by their shortest distances to the current term. Also, only direct children EC terms of the current EC term are listed.

Structural Classification of Proteins (SCOP)
SCOP classifies evolutionary-related domains into Superfamily level and Family level. Accordingly, we have generated the domain-centric EC annotations for each of the three concepts at each of the two domain levels.

Structural Domain Enzyme Commission Ontology (SDEO)
As domain-centric ontology, SDEO only refers to those EC terms which are the most informative to annotate SCOP domains.

EC annotations for SCOP domains
For details, please visit Documentation: EC annotations for SCOP domains. Therein, we provide several relevant files (Data Availability) for the download, including an annotation file (i.e., Domain2EC.txt) and the corresponding ontology (i.e., SDEO.txt).

Supra-domain Enzyme Commission Ontology (SPEO)
As an extension, SPEO includes those EC terms which are the most informative to annotate supra-domains and individual SCOP domains at the Superfamily level.

EC annotations for Supra-domains
For details, please visit Documentation: EC annotations for Supra-domains. Therein, we provide several relevant files (Data Availability) for the download, including a annotation file (i.e., SP2EC.txt) and an ontology (i.e., SPEO.txt). For the sake of being browsable, listed below are those supra-domains (single, dual, triple, quad).

Superfamily

Family

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A presence/absence matrix is generated using protein domains and supradomains for all genomes in SUPERFAMILY. The RAxML software is used to produce a single, large tree topology using heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as if individual trees had been produced. However, this data is extracted from the single large tree. This produces a higher quality topology than if the trees had been produced on their own, and allows the trees to be displayed instantly.

Supra-domain (including individual superfamily)

Supra-domains annotated to this EC term (SPEO level: Moderately Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
101386,53720 101386 - all-alpha NTP pyrophosphatases 53720 - ALDH-like	0	DIRECT
55205,52540 55205 - EPT/RTPC-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
51735,54637 51735 - NAD(P)-binding Rossmann-fold domains 54637 - Thioesterase/thiol ester dehydrase-isomerase	0	DIRECT
54637,55718 54637 - Thioesterase/thiol ester dehydrase-isomerase 55718 - SCP-like	0	DIRECT
52283,51735 52283 - Formate/glycerate dehydrogenase catalytic domain-like 51735 - NAD(P)-binding Rossmann-fold domains	0	DIRECT
51569,53223 51569 - Aldolase 53223 - Aminoacid dehydrogenase-like, N-terminal domain	0	DIRECT
52540,51569 52540 - P-loop containing nucleoside triphosphate hydrolases 51569 - Aldolase	0	DIRECT
51735,48179 51735 - NAD(P)-binding Rossmann-fold domains 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like	0	DIRECT
51735,53659 51735 - NAD(P)-binding Rossmann-fold domains 53659 - Isocitrate/Isopropylmalate dehydrogenase-like	0	DIRECT
56176,56194 56176 - FAD-binding/transporter-associated domain-like 56194 - Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain	0	DIRECT
53927,53597 53927 - Cytidine deaminase-like 53597 - Dihydrofolate reductase-like	0	DIRECT
48179,52096 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like 52096 - ClpP/crotonase	0	DIRECT
52096,51735 52096 - ClpP/crotonase 51735 - NAD(P)-binding Rossmann-fold domains	0	DIRECT
51735,55021 51735 - NAD(P)-binding Rossmann-fold domains 55021 - ACT-like	0	DIRECT
48179,54637 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like 54637 - Thioesterase/thiol ester dehydrase-isomerase	0	DIRECT
53720,56796 53720 - ALDH-like 56796 - Dehydroquinate synthase-like	0	DIRECT
55347,55021 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain 55021 - ACT-like	0	DIRECT
48179,52413 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like 52413 - UDP-glucose/GDP-mannose dehydrogenase C-terminal domain	0	DIRECT
51735,56327 51735 - NAD(P)-binding Rossmann-fold domains 56327 - LDH C-terminal domain-like	0	DIRECT
51735,143548 51735 - NAD(P)-binding Rossmann-fold domains 143548 - Serine metabolism enzymes domain	0	DIRECT
50998,46626 50998 - Quinoprotein alcohol dehydrogenase-like 46626 - Cytochrome c	0	DIRECT
51412,51412 51412 - Inosine monophosphate dehydrogenase (IMPDH) 51412 - Inosine monophosphate dehydrogenase (IMPDH)	0	DIRECT
51735,50129 51735 - NAD(P)-binding Rossmann-fold domains 50129 - GroES-like	0	DIRECT
48179,48179 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like	0	DIRECT
50129,51735 50129 - GroES-like 51735 - NAD(P)-binding Rossmann-fold domains	0	DIRECT
55035,56542 55035 - NAD-binding domain of HMG-CoA reductase 56542 - Substrate-binding domain of HMG-CoA reductase	0	DIRECT
55021,51735 55021 - ACT-like 51735 - NAD(P)-binding Rossmann-fold domains	0	DIRECT
56796,55205 56796 - Dehydroquinate synthase-like 55205 - EPT/RTPC-like	0	DIRECT
54631,51412 54631 - CBS-domain pair 51412 - Inosine monophosphate dehydrogenase (IMPDH)	0	DIRECT
50486,51735 50486 - FMT C-terminal domain-like 51735 - NAD(P)-binding Rossmann-fold domains	0	DIRECT
55347,69055 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain 69055 - 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain	0	DIRECT
53223,51735 53223 - Aminoacid dehydrogenase-like, N-terminal domain 51735 - NAD(P)-binding Rossmann-fold domains	0.00000000000001871	DIRECT
143548,55021 143548 - Serine metabolism enzymes domain 55021 - ACT-like	0.000000000004169	DIRECT
53633,55021 53633 - Carbamate kinase-like 55021 - ACT-like	0.000000006398	DIRECT
53328,50486 53328 - Formyltransferase 50486 - FMT C-terminal domain-like	0.000000009636	DIRECT
47336,53474 47336 - ACP-like 53474 - alpha/beta-Hydrolases	0.00000004075	DIRECT
54637,54637 54637 - Thioesterase/thiol ester dehydrase-isomerase 54637 - Thioesterase/thiol ester dehydrase-isomerase	0.0000007809	DIRECT
51735,47336 51735 - NAD(P)-binding Rossmann-fold domains 47336 - ACP-like	0.0002337	DIRECT
51735,51735 51735 - NAD(P)-binding Rossmann-fold domains 51735 - NAD(P)-binding Rossmann-fold domains	0.000527	DIRECT
51905,54373 51905 - FAD/NAD(P)-binding domain 54373 - FAD-linked reductases, C-terminal domain	0.001651	INHERITED FROM: With a quinone or similar compound as acceptor \|\| Pyranose oxidase \|\| Glycerol-3-phosphate dehydrogenase \|\| With other acceptors \|\| With oxygen as acceptor \|\| Choline dehydrogenase
141734,101386 141734 - HisI-like 101386 - all-alpha NTP pyrophosphatases	0.01249	INHERITED FROM: Histidinol dehydrogenase
52151,55048 52151 - FabD/lysophospholipase-like 55048 - Probable ACP-binding domain of malonyl-CoA ACP transacylase	0.0135	INHERITED FROM: 3-oxoacyl-[acyl-carrier-protein] reductase
55021,55021 55021 - ACT-like 55021 - ACT-like	0.08599	INHERITED FROM: Homoserine dehydrogenase
56176,55103 56176 - FAD-binding/transporter-associated domain-like 55103 - FAD-linked oxidases, C-terminal domain	0.215	INHERITED FROM: D-lactate dehydrogenase (cytochrome) \|\| With a cytochrome as acceptor
51735,55347 51735 - NAD(P)-binding Rossmann-fold domains 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	0.9154	INHERITED FROM: Inositol 2-dehydrogenase \|\| Glucose-6-phosphate dehydrogenase \|\| With NAD(+) or NADP(+) as acceptor \|\| Homoserine dehydrogenase \|\| D-xylose 1-dehydrogenase (NADP(+)) \|\| 1-deoxy-D-xylulose-5-phosphate reductoisomerase \|\| D-chiro-inositol 3-dehydrogenase

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Acting on the CH-OH group of donors

Superfamily

Family

Supra-domain (including individual superfamily)