Quinoprotein alcohol dehydrogenase-like family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: 8-bladed beta-propeller [ 50997] (3)
• Superfamily: Quinoprotein alcohol dehydrogenase-like [ 50998]
• Family: Quinoprotein alcohol dehydrogenase-like [ 50999] (3)

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Family statistics

	Genomes (536)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	1,237	15,041	9
Proteins	1,237	15,040	9

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	With a cytochrome as acceptor	0.00000000000001073	2.264	--	DIRECT
Enzyme Commission (EC)	Acting on the CH-OH group of donors	0.0000000003678	0.935	--	DIRECT
Enzyme Commission (EC)	Methanol dehydrogenase (cytochrome c)	0.0000751	2.741	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorous-containing groups	0.01462	0.2728	--	INHERITED FROM: Non-specific serine/threonine protein kinase || Protein-serine/threonine kinases
Enzyme Commission (EC)	Transferases	0.6286	0	--	INHERITED FROM: Non-specific serine/threonine protein kinase || Protein-serine/threonine kinases
Enzyme Commission (EC)	Oxidoreductases	0.0000000000227	0.3212	Least Informative	DIRECT
Enzyme Commission (EC)	Protein-serine/threonine kinases	0.000000001419	1.042	Moderately Informative	DIRECT
Enzyme Commission (EC)	Non-specific serine/threonine protein kinase	0.00000000006169	1.279	Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	behavior variant	0	0.6859	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	gene expression variant	0	0.6256	--	DIRECT
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	lipid metabolism variant	0	1.337	--	DIRECT
Worm Phenotype (WP)	drug response variant	0	1.135	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	organ system morphology variant	0	0.7516	--	DIRECT
Worm Phenotype (WP)	transgene expression variant	0	0.773	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	transgene subcellular localization variant	0	1.125	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || fat content variant || organism metabolism processing variant || reproductive system physiology variant || transgene expression variant || gene expression variant || fat content increased || chemical response variant || organism homeostasis metabolism variant || lethal || organism physiology variant || transgene subcellular localization variant || development variant || hermaphrodite sterile || organism environmental stimulus response variant || drug response variant || hermaphrodite fertility reduced || lipid metabolism variant || embryonic development variant || embryonic lethal || fertility variant || behavior variant || pattern of transgene expression variant || postembryonic development variant || organ system physiology variant || organism behavior variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	organism metabolism processing variant	0	0.4899	Least Informative	DIRECT
Worm Phenotype (WP)	organism behavior variant	0	0.6859	Least Informative	DIRECT
Worm Phenotype (WP)	organism environmental stimulus response variant	0	0.6614	Least Informative	DIRECT
Worm Phenotype (WP)	chemical response variant	0	0.9053	Moderately Informative	DIRECT
Worm Phenotype (WP)	pattern of transgene expression variant	0	0.9833	Moderately Informative	DIRECT
Worm Phenotype (WP)	fat content variant	0	1.407	Informative	DIRECT
Worm Phenotype (WP)	fat content increased	0	2.07	Highly Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	With a cytochrome as acceptor	0	2.753	--	DIRECT
Enzyme Commission (EC)	With a quinone or similar compound as acceptor	0	2.531	--	DIRECT
Enzyme Commission (EC)	Acting on the CH-OH group of donors	0.00000000000002368	1.372	--	DIRECT
Enzyme Commission (EC)	Non-specific serine/threonine protein kinase	0.00000000005121	1.639	--	DIRECT
Enzyme Commission (EC)	With a copper protein as acceptor	0.0000000008406	2.929	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0.02563	0.7021	--	INHERITED FROM: Protein-serine/threonine kinases || Non-specific serine/threonine protein kinase
Enzyme Commission (EC)	Oxidoreductases	1.855e-16	0.7328	Least Informative	DIRECT
Enzyme Commission (EC)	Transferases	0.8829	0.3972	Least Informative	INHERITED FROM: Protein-serine/threonine kinases || Non-specific serine/threonine protein kinase
Enzyme Commission (EC)	Protein-serine/threonine kinases	0.000000001231	1.437	Informative	DIRECT

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