Non-specific serine/threonine protein kinase

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Root: EC Hierarchy (from IntEnz release 70)

Shortest distance to current term (+ for parents, - for children)	EC term [EC ID] <#Children>	(#SF|#FA)	#Supra-domain (Single|Duplex|Triple)
+ + + + 4:	root [root] <6>
+ + + 3:	Transferases [2] <10>	(363|551)	(398|460|240)
+ + 2:	Transferring phosphorous-containing groups [2.7] <13>	(220|294)	(251|300|176)
+ 1:	Protein-serine/threonine kinases [2.7.11] <31>	(46|50)	(57|86|38)
0:	Non-specific serine/threonine protein kinase [2.7.11.1]	(26|29)	(34|56|23)

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Superfamily

Superfamily domains annotated to this EC term (Not in SDEO)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
DEATH domain	0	DIRECT
RCC1/BLIP-II	0	DIRECT
RNI-like	0	DIRECT
Myosin rod fragments	0	DIRECT
MAST3 pre-PK domain-like	0	DIRECT
KA1-like	0	DIRECT
Quinoprotein alcohol dehydrogenase-like	0	DIRECT
Ankyrin repeat	0	DIRECT
alpha-D-mannose-specific plant lectins	0	DIRECT
G protein-binding domain	0	DIRECT
SMAD/FHA domain	0	DIRECT
Spectrin repeat	0	DIRECT
Doublecortin (DC)	0	DIRECT
DBL homology domain (DH-domain)	0	DIRECT
MIT domain	0	DIRECT
L domain-like	0	DIRECT
Concanavalin A-like lectins/glucanases	0	DIRECT
FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	2.368e-16	DIRECT
CRAL/TRIO domain	0.000000000004879	DIRECT
PX domain	0.000000000705	DIRECT
ARM repeat	0.000000001226	DIRECT
UBA-like	0.000000005279	DIRECT
PYP-like sensor domain (PAS domain)	0.000000358	DIRECT
TPR-like	0.000004641	DIRECT
EF-hand	0.0001582	DIRECT
PDZ domain-like	0.0002247	DIRECT

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Family

Family domains annotated to this (SDEO level: Informative)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Kinase associated domain 1, KA1	0	DIRECT
Spectrin repeat	0	DIRECT
Legume lectins	0	DIRECT
RIO1-like kinases	0	DIRECT
Regulator of chromosome condensation RCC1	0	DIRECT
RhoA-binding domain	0	DIRECT
Doublecortin (DC)	0	DIRECT
MIT domain	0	DIRECT
Myosin rod fragments	0	DIRECT
alpha-D-mannose-specific plant lectins	0	DIRECT
DEATH domain, DD	0	DIRECT
FHA domain	0	DIRECT
Phoshoinositide 3-kinase (PI3K), catalytic domain	0	DIRECT
Polygalacturonase inhibiting protein PGIP	0	DIRECT
RWD domain	0	DIRECT
Ssp2 C-terminal domain-like	0	DIRECT
LIM domain	0	DIRECT
Ankyrin repeat	0	DIRECT
Histidine kinase	0	DIRECT
DBL homology domain (DH-domain)	0	DIRECT
MAST3 pre-PK domain-like	0	DIRECT
FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	3.476e-16	DIRECT
Motor proteins	0.000000000009639	DIRECT
Quinoprotein alcohol dehydrogenase-like	0.00000000006169	DIRECT
PX domain	0.0000000003043	DIRECT
Flavin-binding PAS domain	0.00000002453	DIRECT
Phoshoinositide 3-kinase (PI3K) helical domain	0.0000007007	DIRECT
Calmodulin-like	0.00008592	DIRECT
Ras-binding domain, RBD	0.0004238	DIRECT

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Supra-domain (including individual superfamily)

Supra-domains annotated to this EC term (SPEO level: Moderately Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Penicillin-binding protein 2x (pbp-2x), c-terminal domain	0	DIRECT
TAF(II)230 TBP-binding fragment	0	DIRECT
G protein-binding domain	0	DIRECT
Doublecortin (DC)	0	DIRECT
MAST3 pre-PK domain-like	0	DIRECT
Quinoprotein alcohol dehydrogenase-like	0	DIRECT
Tricorn protease domain 2	0	DIRECT
alpha-D-mannose-specific plant lectins	0	DIRECT
L domain-like	0	DIRECT
DBL homology domain (DH-domain)	0	DIRECT
RNI-like	0	DIRECT
RCC1/BLIP-II	0	DIRECT
Cyclin-like	0	DIRECT
Concanavalin A-like lectins/glucanases	0	DIRECT
SMAD/FHA domain	0	DIRECT
Myosin rod fragments	0	DIRECT
DEATH domain	0	DIRECT
MIT domain	0	DIRECT
KA1-like	0	DIRECT
Spectrin repeat	0	DIRECT
Ankyrin repeat	0	DIRECT
FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)	1.756e-16	DIRECT
CRAL/TRIO domain	0.000000000003677	DIRECT
PX domain	0.0000000005446	DIRECT
ARM repeat	0.00000000098	DIRECT
UBA-like	0.000000009828	DIRECT
C-type lectin-like	0.0000000115	DIRECT
PYP-like sensor domain (PAS domain)	0.0000002821	DIRECT
Chaperone J-domain	0.0000005998	DIRECT
GTPase activation domain, GAP	0.0000005998	DIRECT
TPR-like	0.000003727	DIRECT
EF-hand	0.0001339	DIRECT
Bromodomain	0.0001551	DIRECT
PDZ domain-like	0.0001904	DIRECT

Supra-domains annotated to this EC term (SPEO level: Moderately Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
52058,52047 52058 - L domain-like 52047 - RNI-like	0	DIRECT
56112,48403 56112 - Protein kinase-like (PK-like) 48403 - Ankyrin repeat	0	DIRECT
49899,56112 49899 - Concanavalin A-like lectins/glucanases 56112 - Protein kinase-like (PK-like)	0	DIRECT
53067,56112 53067 - Actin-like ATPase domain 56112 - Protein kinase-like (PK-like)	0	DIRECT
47986,56112 47986 - DEATH domain 56112 - Protein kinase-like (PK-like)	0	DIRECT
52047,56112 52047 - RNI-like 56112 - Protein kinase-like (PK-like)	0	DIRECT
52058,56112 52058 - L domain-like 56112 - Protein kinase-like (PK-like)	0	DIRECT
57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain)	0	DIRECT
48371,48371 48371 - ARM repeat 48371 - ARM repeat	0	DIRECT
116846,116846 116846 - MIT domain 116846 - MIT domain	0	DIRECT
50998,56112 50998 - Quinoprotein alcohol dehydrogenase-like 56112 - Protein kinase-like (PK-like)	0	DIRECT
89837,89837 89837 - Doublecortin (DC) 89837 - Doublecortin (DC)	0	DIRECT
52058,52058 52058 - L domain-like 52058 - L domain-like	0	DIRECT
56112,103243 56112 - Protein kinase-like (PK-like) 103243 - KA1-like	0	DIRECT
48726,56112 48726 - Immunoglobulin 56112 - Protein kinase-like (PK-like)	0	DIRECT
56112,48371 56112 - Protein kinase-like (PK-like) 48371 - ARM repeat	0	DIRECT
52087,46966 52087 - CRAL/TRIO domain 46966 - Spectrin repeat	0	DIRECT
52058,52540 52058 - L domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
56112,55681 56112 - Protein kinase-like (PK-like) 55681 - Class II aaRS and biotin synthetases	0	DIRECT
47370,47370 47370 - Bromodomain 47370 - Bromodomain	0	DIRECT
55073,56112 55073 - Nucleotide cyclase 56112 - Protein kinase-like (PK-like)	0	DIRECT
52047,52058 52047 - RNI-like 52058 - L domain-like	0	DIRECT
57716,50156 57716 - Glucocorticoid receptor-like (DNA-binding domain) 50156 - PDZ domain-like	0	DIRECT
56112,50998 56112 - Protein kinase-like (PK-like) 50998 - Quinoprotein alcohol dehydrogenase-like	0	DIRECT
48065,50729 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like	0	DIRECT
64268,56112 64268 - PX domain 56112 - Protein kinase-like (PK-like)	0	DIRECT
56112,116846 56112 - Protein kinase-like (PK-like) 116846 - MIT domain	0	DIRECT
56112,90257 56112 - Protein kinase-like (PK-like) 90257 - Myosin rod fragments	0	DIRECT
48403,56112 48403 - Ankyrin repeat 56112 - Protein kinase-like (PK-like)	0	DIRECT
56112,54928 56112 - Protein kinase-like (PK-like) 54928 - RNA-binding domain, RBD	0	DIRECT
46785,56112 46785 - "Winged helix" DNA-binding domain 56112 - Protein kinase-like (PK-like)	0	DIRECT
52047,52047 52047 - RNI-like 52047 - RNI-like	0	DIRECT
56112,50985 56112 - Protein kinase-like (PK-like) 50985 - RCC1/BLIP-II	0	DIRECT
50729,69322 50729 - PH domain-like 69322 - Tricorn protease domain 2	0	DIRECT
46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat	0	DIRECT
56112,48452 56112 - Protein kinase-like (PK-like) 48452 - TPR-like	0	DIRECT
49879,56112 49879 - SMAD/FHA domain 56112 - Protein kinase-like (PK-like)	0	DIRECT
50156,56112 50156 - PDZ domain-like 56112 - Protein kinase-like (PK-like)	0	DIRECT
54236,57889 54236 - Ubiquitin-like 57889 - Cysteine-rich domain	0	DIRECT
53850,56112 53850 - Periplasmic binding protein-like II 56112 - Protein kinase-like (PK-like)	0	DIRECT
56112,52799 56112 - Protein kinase-like (PK-like) 52799 - (Phosphotyrosine protein) phosphatases II	0	DIRECT
48371,56112 48371 - ARM repeat 56112 - Protein kinase-like (PK-like)	0	DIRECT
47212,56112 47212 - FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) 56112 - Protein kinase-like (PK-like)	1.756e-16	DIRECT
50729,57889 50729 - PH domain-like 57889 - Cysteine-rich domain	0.000000000000002087	DIRECT
49265,48726 49265 - Fibronectin type III 48726 - Immunoglobulin	0.0000000000001068	DIRECT
50729,50044 50729 - PH domain-like 50044 - SH3-domain	0.00000000003241	DIRECT
56112,50044 56112 - Protein kinase-like (PK-like) 50044 - SH3-domain	0.0000000115	DIRECT
56112,52540 56112 - Protein kinase-like (PK-like) 52540 - P-loop containing nucleoside triphosphate hydrolases	0.00000004184	DIRECT
48403,52540 48403 - Ankyrin repeat 52540 - P-loop containing nucleoside triphosphate hydrolases	0.000000204	DIRECT
54768,54768 54768 - dsRNA-binding domain-like 54768 - dsRNA-binding domain-like	0.000000204	DIRECT
49562,48371 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat	0.000000299	DIRECT
48403,47769 48403 - Ankyrin repeat 47769 - SAM/Pointed domain	0.000001374	DIRECT
53850,53850 53850 - Periplasmic binding protein-like II 53850 - Periplasmic binding protein-like II	0.000004777	DIRECT
52799,49562 52799 - (Phosphotyrosine protein) phosphatases II 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)	0.00002544	DIRECT
56112,47473 56112 - Protein kinase-like (PK-like) 47473 - EF-hand	0.0001339	DIRECT
56112,56112 56112 - Protein kinase-like (PK-like) 56112 - Protein kinase-like (PK-like)	0.0002693	DIRECT

Supra-domains annotated to this EC term (SPEO level: Moderately Informative)
Highlighted in gray are those with FDR>0.001

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
52087,46966,46966 52087 - CRAL/TRIO domain 46966 - Spectrin repeat 46966 - Spectrin repeat	0	DIRECT
48726,49265,48726 48726 - Immunoglobulin 49265 - Fibronectin type III 48726 - Immunoglobulin	0	DIRECT
52058,52058,56112 52058 - L domain-like 52058 - L domain-like 56112 - Protein kinase-like (PK-like)	0	DIRECT
52047,52047,52058 52047 - RNI-like 52047 - RNI-like 52058 - L domain-like	0	DIRECT
57716,57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain)	0	DIRECT
57716,57716,50156 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain) 50156 - PDZ domain-like	0	DIRECT
56112,52799,49562 56112 - Protein kinase-like (PK-like) 52799 - (Phosphotyrosine protein) phosphatases II 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)	0	DIRECT
49265,48726,49265 49265 - Fibronectin type III 48726 - Immunoglobulin 49265 - Fibronectin type III	0	DIRECT
52047,52047,56112 52047 - RNI-like 52047 - RNI-like 56112 - Protein kinase-like (PK-like)	0	DIRECT
57889,50729,69322 57889 - Cysteine-rich domain 50729 - PH domain-like 69322 - Tricorn protease domain 2	0	DIRECT
56112,48726,48726 56112 - Protein kinase-like (PK-like) 48726 - Immunoglobulin 48726 - Immunoglobulin	0	DIRECT
52058,52047,56112 52058 - L domain-like 52047 - RNI-like 56112 - Protein kinase-like (PK-like)	0	DIRECT
48065,50729,50044 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like 50044 - SH3-domain	0	DIRECT
56112,48403,52540 56112 - Protein kinase-like (PK-like) 48403 - Ankyrin repeat 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
48726,48726,56112 48726 - Immunoglobulin 48726 - Immunoglobulin 56112 - Protein kinase-like (PK-like)	0	DIRECT
52058,52047,52058 52058 - L domain-like 52047 - RNI-like 52058 - L domain-like	0	DIRECT
52047,52058,56112 52047 - RNI-like 52058 - L domain-like 56112 - Protein kinase-like (PK-like)	0	DIRECT
53850,53850,56112 53850 - Periplasmic binding protein-like II 53850 - Periplasmic binding protein-like II 56112 - Protein kinase-like (PK-like)	0	DIRECT
56112,116846,116846 56112 - Protein kinase-like (PK-like) 116846 - MIT domain 116846 - MIT domain	0	DIRECT
57716,50156,56112 57716 - Glucocorticoid receptor-like (DNA-binding domain) 50156 - PDZ domain-like 56112 - Protein kinase-like (PK-like)	0	DIRECT
52058,52058,52058 52058 - L domain-like 52058 - L domain-like 52058 - L domain-like	0.000000000007873	DIRECT
49265,48726,48726 49265 - Fibronectin type III 48726 - Immunoglobulin 48726 - Immunoglobulin	0.0000000005755	DIRECT
49562,48371,56112 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat 56112 - Protein kinase-like (PK-like)	0.000000299	DIRECT