Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: open-sided beta-meander [ 51086] (2)
• Superfamily: Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain [ 82185]
• Family: Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain [ 82186]

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Family statistics

	Genomes (58)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	66	190	8
Proteins	66	190	8

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferases	0	0	--	DIRECT
Enzyme Commission (EC)	1-phosphatidylinositol-4-phosphate 5-kinase	0	2.44	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorous-containing groups	0.02713	0.2728	--	INHERITED FROM: 1-phosphatidylinositol-4-phosphate 5-kinase || Phosphotransferases with an alcohol group as accep
Enzyme Commission (EC)	Transferring one-carbon groups	0.05576	0.72	Least Informative	INHERITED FROM: Methyltransferases || Histone-lysine N-methyltransferase
Enzyme Commission (EC)	Phosphotransferases with an alcohol group as accep	0.0000000000001184	0.8381	Moderately Informative	DIRECT
Enzyme Commission (EC)	Methyltransferases	0.00002936	0.8169	Moderately Informative	DIRECT
Enzyme Commission (EC)	Histone-lysine N-methyltransferase	0.00000000000004555	1.595	Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0	0.2371	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0	0.3869	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0	0.4756	Least Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	decreased exploration in new environment	0.00001857	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal exploration in a new environment	0.0001021	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal response to new environment	0.0002107	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal cognition	0.0132	1.399	--	INHERITED FROM: abnormal exploration in a new environment || abnormal response to new environment || decreased exploration in new environment
Mammalian Phenotype (MP)	abnormal nervous system physiology	0.1178	0.825	--	INHERITED FROM: abnormal nervous system electrophysiology
Mammalian Phenotype (MP)	behavior/neurological phenotype	0.1398	0.8178	--	INHERITED FROM: abnormal response to new environment || abnormal exploration in a new environment || abnormal response to novelty || decreased exploration in new environment
Mammalian Phenotype (MP)	nervous system phenotype	0.3666	0.4959	Least Informative	INHERITED FROM: abnormal nervous system electrophysiology
Mammalian Phenotype (MP)	abnormal behavior	1	0.855	Moderately Informative	INHERITED FROM: abnormal response to new environment || abnormal exploration in a new environment || decreased exploration in new environment || abnormal response to novelty
Mammalian Phenotype (MP)	abnormal nervous system electrophysiology	0.0008865	1.7	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal learning/memory/conditioning	0.00729	1.399	Informative	INHERITED FROM: decreased exploration in new environment || abnormal response to new environment || abnormal exploration in a new environment
Mammalian Phenotype (MP)	abnormal emotion/affect behavior	0.009812	1.524	Informative	INHERITED FROM: abnormal response to novelty || abnormal response to new environment || abnormal exploration in a new environment || decreased exploration in new environment
Mammalian Phenotype (MP)	abnormal response to novelty	0.0005047	2.126	Highly Informative	DIRECT

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.06546	--	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	embryonic/larval nervous system	0	0.7171	--	DIRECT
Fly Anatomy (FA)	adult nervous system	0	0.7764	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.1823	--	DIRECT
Fly Anatomy (FA)	cell	0	0.4069	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || nervous system || peripheral nervous system || neuron || adult || embryonic/larval nervous system || adult nervous system || larva || somatic cell || cell || organ system subdivision || organ system || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: organ system || multicellular structure || organ system subdivision || cell || larva || somatic cell || neuron || adult || embryonic/larval nervous system || adult nervous system || organism || nervous system || peripheral nervous system
Fly Anatomy (FA)	larva	0	0.3763	Least Informative	DIRECT
Fly Anatomy (FA)	adult	0	0.4496	Least Informative	DIRECT
Fly Anatomy (FA)	nervous system	0	0.6333	Least Informative	DIRECT
Fly Anatomy (FA)	organ system subdivision	0	0.4301	Least Informative	DIRECT
Fly Anatomy (FA)	somatic cell	0	0.4861	Least Informative	DIRECT
Fly Anatomy (FA)	peripheral nervous system	0	0.8978	Moderately Informative	DIRECT
Fly Anatomy (FA)	neuron	0	0.8451	Moderately Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	epidermal cell	0	0.2152	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2046	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1621	--	DIRECT
Plant ANatomical entity (PAN)	plant organ	0	0.2391	--	DIRECT
Plant ANatomical entity (PAN)	plant axis	0	0.3257	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2335	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || multi-tissue plant structure || portion of plant tissue || plant organ || epidermis || epidermal cell || plant axis || plant cell
Plant structure DEvelopment stage (PDE)	whole plant development stage	0	0.1547	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0	0.1593	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1484	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.1648	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant embryo stage	0	0.2319	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: corolla development stage || flowering stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.1584	--	INHERITED FROM: sporophyte vegetative stage || E expanded cotyledon stage || plant embryo stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || flowering stage || corolla development stage || plant organ development stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.1584	--	INHERITED FROM: E expanded cotyledon stage || sporophyte vegetative stage || plant embryo stage
Plant structure DEvelopment stage (PDE)	E expanded cotyledon stage	0	0.2861	Least Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0	0.7021	--	DIRECT
Enzyme Commission (EC)	1-phosphatidylinositol-4-phosphate 5-kinase	0	2.929	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0.3972	Least Informative	DIRECT
Enzyme Commission (EC)	Phosphotransferases with an alcohol group as acceptor	0	1.238	Moderately Informative	DIRECT

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