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Phosphotransferases with an alcohol group as accep
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Enzyme Commission (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed. To navigate hierarchical structure of EC, we display all parental EC terms to the current EC term of interest ordered by their shortest distances to the current term. Also, only direct children EC terms of the current EC term are listed.
Structural Classification of Proteins (SCOP)
SCOP classifies evolutionary-related domains into Superfamily level and Family level. Accordingly, we have generated the domain-centric EC annotations for each of the three concepts at each of the two domain levels.
Structural Domain Enzyme Commission Ontology (SDEO)
As domain-centric ontology, SDEO only refers to those EC terms which are the most informative to annotate SCOP domains.
EC annotations for SCOP domains
For details, please visit Documentation: EC annotations for SCOP domains. Therein, we provide several relevant files ( Data Availability) for the download, including an annotation file (i.e., Domain2EC.txt) and the corresponding ontology (i.e., SDEO.txt).
Supra-domain Enzyme Commission Ontology (SPEO)
As an extension, SPEO includes those EC terms which are the most informative to annotate supra-domains and individual SCOP domains at the Superfamily level.
EC annotations for Supra-domains
For details, please visit Documentation: EC annotations for Supra-domains. Therein, we provide several relevant files ( Data Availability) for the download, including a annotation file (i.e., SP2EC.txt) and an ontology (i.e., SPEO.txt). For the sake of being browsable, listed below are those supra-domains (single, dual, triple, quad).
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Root: EC Hierarchy (from IntEnz release 70)
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this (SDEO level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain | 0 | DIRECT |
| Pyruvate kinase | 0 | DIRECT |
| CoaX-like | 0 | DIRECT |
| AF1104-like | 0 | DIRECT |
| ADP-specific Phosphofructokinase/Glucokinase | 0 | DIRECT |
| Thiamin biosynthesis kinases | 0 | DIRECT |
| PTS IIb component | 0 | DIRECT |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | DIRECT |
| Phosphoribulokinase/pantothenate kinase | 0 | DIRECT |
| GHMP Kinase, N-terminal domain | 0 | DIRECT |
| MarR-like transcriptional regulators | 0 | DIRECT |
| APH phosphotransferases | 0 | DIRECT |
| Ribokinase-like | 0 | DIRECT |
| CTP-dependent riboflavin kinase-like | 0 | DIRECT |
| Tpt1/KptA | 0 | DIRECT |
| Glycerol kinase | 0 | DIRECT |
| PTS system, Lactose/Cellobiose specific IIB subunit | 0 | DIRECT |
| DhaL-like | 0 | DIRECT |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain | 0 | DIRECT |
| RpiR-like | 0 | DIRECT |
| Galactokinase | 0 | DIRECT |
| DAK1 | 0 | DIRECT |
| Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta | 0 | DIRECT |
| Glucose permease-like | 0 | DIRECT |
| Type II thymidine kinase | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), apical domain | 0 | DIRECT |
| Mevalonate kinase | 0 | DIRECT |
| Dehydroquinate synthase, DHQS | 0 | DIRECT |
| Glycerate kinase I | 0 | DIRECT |
| Glucokinase | 0 | DIRECT |
| Shikimate kinase (AroK) | 0 | DIRECT |
| PfkB-like kinase | 0 | DIRECT |
| Homoserine kinase | 0 | DIRECT |
| Gluconate kinase | 0 | DIRECT |
| NAD kinase-like | 0 | DIRECT |
| Phosphofructokinase | 0 | DIRECT |
| Choline kinase | 0 | DIRECT |
| ATP-dependent riboflavin kinase-like | 0 | DIRECT |
| Fumble-like | 0 | DIRECT |
| Pyruvate kinase beta-barrel domain | 0 | DIRECT |
| Hexokinase | 0 | DIRECT |
| Shikimate dehydrogenase-like | 0 | DIRECT |
| Pyruvate kinase, C-terminal domain | 0 | DIRECT |
| phosphatase domain of polynucleotide kinase | 0 | DIRECT |
| Diacylglycerol kinase-like | 0 | DIRECT |
| Type II thymidine kinase zinc finger | 0 | DIRECT |
| Adenosine-5'phosphosulfate kinase (APS kinase) | 0 | DIRECT |
| PTS system, Fructose specific IIB subunit-like | 0 | DIRECT |
| 4-(cytidine 5'-diphospho)-2C-methyl-D-erythritol kinase IspE | 0 | DIRECT |
| ROK | 0 | DIRECT |
| Glucose permease domain IIB | 0 | DIRECT |
| GckA/TtuD-like | 0.00000000000000121 | DIRECT |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.000000000000009211 | DIRECT |
| Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 0.0000000000001184 | DIRECT |
| BadF/BadG/BcrA/BcrD-like | 0.00000001379 | DIRECT |
| EF-hand modules in multidomain proteins | 0.0000000664 | DIRECT |
| FYVE, a phosphatidylinositol-3-phosphate binding domain | 0.0000001859 | DIRECT |
| TENA/THI-4 | 0.0000003363 | DIRECT |
| IIA domain of mannitol-specific and ntr phosphotransferase EII | 0.0000007047 | DIRECT |
| Inositol polyphosphate kinase (IPK) | 0.00002739 | DIRECT |
| Enolpyruvate transferase, EPT | 0.00003409 | DIRECT |
| Ras-binding domain, RBD | 0.001842 | INHERITED FROM: Phosphatidylinositol-4,5-bisphosphate 3-kinase |
| PX domain | 0.005228 | INHERITED FROM: Phosphatidylinositol-4-phosphate 3-kinase |
| PLC-like (P variant) | 0.02382 | INHERITED FROM: Phosphatidylinositol-4,5-bisphosphate 3-kinase |
| Class I aldolase | 0.08728 | INHERITED FROM: Shikimate kinase |
| Synaptotagmin-like (S variant) | 0.6586 | INHERITED FROM: Phosphatidylinositol-4-phosphate 3-kinase |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.6992 | INHERITED FROM: Diacylglycerol kinase |
| Ankyrin repeat | 0.8591 | INHERITED FROM: Diacylglycerol kinase |
| mono-SIS domain | 0.9474 | INHERITED FROM: Glucokinase |
| SAM (sterile alpha motif) domain | 0.9823 | INHERITED FROM: Diacylglycerol kinase |
| Phosphoribosyltransferases (PRTases) | 1 | INHERITED FROM: Uridine kinase |
| G proteins | 1 | INHERITED FROM: Adenylyl-sulfate kinase |
| Adenylyltransferase | 1 | INHERITED FROM: Riboflavin kinase |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 1 | INHERITED FROM: Adenylyl-sulfate kinase |
| Elongation factors | 1 | INHERITED FROM: Adenylyl-sulfate kinase |
| Pleckstrin-homology domain (PH domain) | 1 | INHERITED FROM: Diacylglycerol kinase |
| Aminoacid dehydrogenase-like, C-terminal domain | 1 | INHERITED FROM: Shikimate kinase |
| ATP sulfurylase catalytic domain | 1 | INHERITED FROM: Adenylyl-sulfate kinase |
| Nucleotide and nucleoside kinases | 1 | INHERITED FROM: Polynucleotide 5'-hydroxyl-kinase || Thymidine kinase || Deoxyguanosine kinase || Dephospho-CoA kinase || Deoxycytidine kinase |
| ATP sulfurylase N-terminal domain | 1 | INHERITED FROM: Adenylyl-sulfate kinase |
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain | 0 | Direct |
| Pyruvate kinase | 0 | Direct |
| CoaX-like | 0 | Direct |
| AF1104-like | 0 | Direct |
| ADP-specific Phosphofructokinase/Glucokinase | 0 | Direct |
| Thiamin biosynthesis kinases | 0 | Direct |
| PTS IIb component | 0 | Direct |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | Direct |
| Phosphoribulokinase/pantothenate kinase | 0 | Direct |
| GHMP Kinase, N-terminal domain | 0 | Direct |
| MarR-like transcriptional regulators | 0 | Direct |
| APH phosphotransferases | 0 | Direct |
| Ribokinase-like | 0 | Direct |
| CTP-dependent riboflavin kinase-like | 0 | Direct |
| Tpt1/KptA | 0 | Direct |
| Glycerol kinase | 0 | Direct |
| PTS system, Lactose/Cellobiose specific IIB subunit | 0 | Direct |
| DhaL-like | 0 | Direct |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain | 0 | Direct |
| RpiR-like | 0 | Direct |
| Galactokinase | 0 | Direct |
| DAK1 | 0 | Direct |
| Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta | 0 | Direct |
| Glucose permease-like | 0 | Direct |
| Type II thymidine kinase | 0 | Direct |
| Group II chaperonin (CCT, TRIC), apical domain | 0 | Direct |
| Mevalonate kinase | 0 | Direct |
| Dehydroquinate synthase, DHQS | 0 | Direct |
| Glycerate kinase I | 0 | Direct |
| Glucokinase | 0 | Direct |
| Shikimate kinase (AroK) | 0 | Direct |
| PfkB-like kinase | 0 | Direct |
| Homoserine kinase | 0 | Direct |
| Gluconate kinase | 0 | Direct |
| NAD kinase-like | 0 | Direct |
| Phosphofructokinase | 0 | Direct |
| Choline kinase | 0 | Direct |
| ATP-dependent riboflavin kinase-like | 0 | Direct |
| Fumble-like | 0 | Direct |
| Pyruvate kinase beta-barrel domain | 0 | Direct |
| Hexokinase | 0 | Direct |
| Shikimate dehydrogenase-like | 0 | Direct |
| Pyruvate kinase, C-terminal domain | 0 | Direct |
| phosphatase domain of polynucleotide kinase | 0 | Direct |
| Diacylglycerol kinase-like | 0 | Direct |
| Type II thymidine kinase zinc finger | 0 | Direct |
| Adenosine-5'phosphosulfate kinase (APS kinase) | 0 | Direct |
| PTS system, Fructose specific IIB subunit-like | 0 | Direct |
| 4-(cytidine 5'-diphospho)-2C-methyl-D-erythritol kinase IspE | 0 | Direct |
| ROK | 0 | Direct |
| Glucose permease domain IIB | 0 | Direct |
| GckA/TtuD-like | 0.00000000000000121 | Direct |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0.000000000000009211 | Direct |
| Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 0.0000000000001184 | Direct |
| BadF/BadG/BcrA/BcrD-like | 0.00000001379 | Direct |
| EF-hand modules in multidomain proteins | 0.0000000664 | Direct |
| FYVE, a phosphatidylinositol-3-phosphate binding domain | 0.0000001859 | Direct |
| TENA/THI-4 | 0.0000003363 | Direct |
| IIA domain of mannitol-specific and ntr phosphotransferase EII | 0.0000007047 | Direct |
| Inositol polyphosphate kinase (IPK) | 0.00002739 | Direct |
| Enolpyruvate transferase, EPT | 0.00003409 | Direct |
| Ras-binding domain, RBD | 0.001842 | Inherited |
| PX domain | 0.005228 | Inherited |
| PLC-like (P variant) | 0.02382 | Inherited |
| Class I aldolase | 0.08728 | Inherited |
| Synaptotagmin-like (S variant) | 0.6586 | Inherited |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.6992 | Inherited |
| Ankyrin repeat | 0.8591 | Inherited |
| mono-SIS domain | 0.9474 | Inherited |
| SAM (sterile alpha motif) domain | 0.9823 | Inherited |
| Phosphoribosyltransferases (PRTases) | 1 | Inherited |
| G proteins | 1 | Inherited |
| Adenylyltransferase | 1 | Inherited |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 1 | Inherited |
| Elongation factors | 1 | Inherited |
| Pleckstrin-homology domain (PH domain) | 1 | Inherited |
| Aminoacid dehydrogenase-like, C-terminal domain | 1 | Inherited |
| ATP sulfurylase catalytic domain | 1 | Inherited |
| Nucleotide and nucleoside kinases | 1 | Inherited |
| ATP sulfurylase N-terminal domain | 1 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this EC term
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Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this EC term (SPEO level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| GroEL apical domain-like | 0 | DIRECT |
| Glucose permease domain IIB | 0 | DIRECT |
| GHMP Kinase, C-terminal domain | 0 | DIRECT |
| PK beta-barrel domain-like | 0 | DIRECT |
| Phosphofructokinase | 0 | DIRECT |
| Actin-like ATPase domain | 0 | DIRECT |
| Duplicated hybrid motif | 0 | DIRECT |
| GroEL-intermediate domain like | 0 | DIRECT |
| PK C-terminal domain-like | 0 | DIRECT |
| DAK1/DegV-like | 0 | DIRECT |
| Trm112p-like | 0 | DIRECT |
| P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
| Ribokinase-like | 0 | DIRECT |
| DhaL-like | 0 | DIRECT |
| PTS-regulatory domain, PRD | 0 | DIRECT |
| Riboflavin kinase-like | 0 | DIRECT |
| SAICAR synthase-like | 0 | DIRECT |
| Glucocorticoid receptor-like (DNA-binding domain) | 0 | DIRECT |
| Phosphoenolpyruvate/pyruvate domain | 0 | DIRECT |
| PTS system IIB component-like | 0 | DIRECT |
| Glycerate kinase I | 0 | DIRECT |
| PTS IIb component | 0 | DIRECT |
| Ribosomal protein S5 domain 2-like | 0 | DIRECT |
| NAD kinase/diacylglycerol kinase-like | 0 | DIRECT |
| AF1104-like | 0 | DIRECT |
| GckA/TtuD-like | 0.000000000000002433 | DIRECT |
| Dehydroquinate synthase-like | 0.0000000000001421 | DIRECT |
| Homeodomain-like | 0.0000000005933 | DIRECT |
| Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 0.000000117 | DIRECT |
| Phoshotransferase/anion transport protein | 0.000001235 | DIRECT |
| ARM repeat | 0.000006884 | DIRECT |
| Ubiquitin-like | 0.00002239 | DIRECT |
| C-terminal domain of transcriptional repressors | 0.000131 | DIRECT |
| ADP-ribosylation | 0.0003199 | DIRECT |
| EPT/RTPC-like | 0.001195 | INHERITED FROM: Shikimate kinase |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.004055 | INHERITED FROM: Phosphatidylinositol-4,5-bisphosphate 3-kinase || Phosphatidylinositol 3-kinase || Phosphatidylinositol-4-phosphate 3-kinase |
| PX domain | 0.006821 | INHERITED FROM: Phosphatidylinositol-4-phosphate 3-kinase |
| Phosphoglycerate mutase-like | 0.01846 | INHERITED FROM: 6-phosphofructo-2-kinase |
| Heme oxygenase-like | 0.0371 | INHERITED FROM: Hydroxymethylpyrimidine kinase |
| Aminoacid dehydrogenase-like, N-terminal domain | 0.06229 | INHERITED FROM: Shikimate kinase |
| FYVE/PHD zinc finger | 0.0736 | INHERITED FROM: 1-phosphatidylinositol-3-phosphate 5-kinase |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0.4172 | INHERITED FROM: 6-phosphofructokinase |
| lambda repressor-like DNA-binding domains | 0.6286 | INHERITED FROM: Ribosylnicotinamide kinase |
| Cysteine-rich domain | 0.6778 | INHERITED FROM: Diacylglycerol kinase |
| EF-hand | 0.8493 | INHERITED FROM: Diacylglycerol kinase |
| Ankyrin repeat | 0.9434 | INHERITED FROM: Diacylglycerol kinase |
| "Winged helix" DNA-binding domain | 0.963 | INHERITED FROM: CTP-dependent riboflavin kinase || 1-phosphatidylinositol-3-phosphate 5-kinase |
| Thiamin phosphate synthase | 0.9944 | INHERITED FROM: Hydroxymethylpyrimidine kinase |
| Nucleotidylyl transferase | 1 | INHERITED FROM: Riboflavin kinase |
| SAM/Pointed domain | 1 | INHERITED FROM: Diacylglycerol kinase |
| PH domain-like | 1 | INHERITED FROM: Diacylglycerol kinase |
| NAD(P)-binding Rossmann-fold domains | 1 | INHERITED FROM: Shikimate kinase |
| PRTase-like | 1 | INHERITED FROM: Uridine kinase |
| Aldolase | 1 | INHERITED FROM: Shikimate kinase |
| UDP-Glycosyltransferase/glycogen phosphorylase | 1 | INHERITED FROM: N-acylmannosamine kinase |
| Phosphoglucomutase, first 3 domains | 1 | INHERITED FROM: Glucose-1,6-bisphosphate synthase |
| Glutathione synthetase ATP-binding domain-like | 1 | INHERITED FROM: Inositol-tetrakisphosphate 1-kinase || Inositol-1,3,4-trisphosphate 5/6-kinase |
| HAD-like | 1 | INHERITED FROM: Polynucleotide 5'-hydroxyl-kinase |
| Protein kinase-like (PK-like) | 1 | INHERITED FROM: 1-phosphatidylinositol 4-kinase || S-methyl-5-thioribose kinase || Homoserine kinase || Phosphatidylinositol-4,5-bisphosphate 3-kinase || Phosphatidylinositol 3-kinase || Choline kinase || 2.7.1.175 || Protein-ribulosamine 3-kinase || Phosphatidylinositol-4-phosphate 3-kinase || Kanamycin kinase || Ethanolamine kinase || Thiamine kinase |
| PUA domain-like | 1 | INHERITED FROM: Adenylyl-sulfate kinase |
| Translation proteins | 1 | INHERITED FROM: Adenylyl-sulfate kinase |
| Phosphohistidine domain | 1 | INHERITED FROM: Pyruvate kinase |
| SIS domain | 1 | INHERITED FROM: Glucokinase |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 1 | INHERITED FROM: Adenylyl-sulfate kinase |
| Phosphoglucomutase, C-terminal domain | 1 | INHERITED FROM: Glucose-1,6-bisphosphate synthase |
(show details)
Supra-domains annotated to this EC term (SPEO level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
63520,63520 63520 - PTS-regulatory domain, PRD 63520 - PTS-regulatory domain, PRD | 0 | DIRECT |
47473,57889 47473 - EF-hand 57889 - Cysteine-rich domain | 0 | DIRECT |
55205,52540 55205 - EPT/RTPC-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
46689,53697 46689 - Homeodomain-like 53697 - SIS domain | 0 | DIRECT |
54593,53784 54593 - Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase 53784 - Phosphofructokinase | 0 | DIRECT |
54849,52029 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like | 0 | DIRECT |
64268,49562 64268 - PX domain 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
52540,88697 52540 - P-loop containing nucleoside triphosphate hydrolases 88697 - PUA domain-like | 0 | DIRECT |
47473,47473 47473 - EF-hand 47473 - EF-hand | 0 | DIRECT |
52540,53254 52540 - P-loop containing nucleoside triphosphate hydrolases 53254 - Phosphoglycerate mutase-like | 0 | DIRECT |
51391,53613 51391 - Thiamin phosphate synthase 53613 - Ribokinase-like | 0 | DIRECT |
82549,101473 82549 - DAK1/DegV-like 101473 - DhaL-like | 0 | DIRECT |
51569,53223 51569 - Aldolase 53223 - Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
46785,82114 46785 - "Winged helix" DNA-binding domain 82114 - Riboflavin kinase-like | 0 | DIRECT |
53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain | 0 | DIRECT |
82185,82185 82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain 82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 0 | DIRECT |
52540,51569 52540 - P-loop containing nucleoside triphosphate hydrolases 51569 - Aldolase | 0 | DIRECT |
50465,52540 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
57889,111331 57889 - Cysteine-rich domain 111331 - NAD kinase/diacylglycerol kinase-like | 0 | DIRECT |
51621,52935 51621 - Phosphoenolpyruvate/pyruvate domain 52935 - PK C-terminal domain-like | 0 | DIRECT |
49562,48371 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat | 0 | DIRECT |
53613,48613 53613 - Ribokinase-like 48613 - Heme oxygenase-like | 0 | DIRECT |
52540,53271 52540 - P-loop containing nucleoside triphosphate hydrolases 53271 - PRTase-like | 0 | DIRECT |
52935,52009 52935 - PK C-terminal domain-like 52009 - Phosphohistidine domain | 0 | DIRECT |
52374,82114 52374 - Nucleotidylyl transferase 82114 - Riboflavin kinase-like | 0 | DIRECT |
56112,64268 56112 - Protein kinase-like (PK-like) 64268 - PX domain | 0 | DIRECT |
52540,81301 52540 - P-loop containing nucleoside triphosphate hydrolases 81301 - Nucleotidyltransferase | 0 | DIRECT |
55804,52794 55804 - Phoshotransferase/anion transport protein 52794 - PTS system IIB component-like | 0 | DIRECT |
63520,52794 63520 - PTS-regulatory domain, PRD 52794 - PTS system IIB component-like | 0 | DIRECT |
52794,52794 52794 - PTS system IIB component-like 52794 - PTS system IIB component-like | 0 | DIRECT |
50800,51621 50800 - PK beta-barrel domain-like 51621 - Phosphoenolpyruvate/pyruvate domain | 0 | DIRECT |
54211,55060 54211 - Ribosomal protein S5 domain 2-like 55060 - GHMP Kinase, C-terminal domain | 0 | DIRECT |
53784,53784 53784 - Phosphofructokinase 53784 - Phosphofructokinase | 0 | DIRECT |
56784,52540 56784 - HAD-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
55604,51261 55604 - Glucose permease domain IIB 51261 - Duplicated hybrid motif | 0 | DIRECT |
52540,57716 52540 - P-loop containing nucleoside triphosphate hydrolases 57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0 | DIRECT |
52794,55804 52794 - PTS system IIB component-like 55804 - Phoshotransferase/anion transport protein | 0 | DIRECT |
50037,53067 50037 - C-terminal domain of transcriptional repressors 53067 - Actin-like ATPase domain | 0 | DIRECT |
56796,55205 56796 - Dehydroquinate synthase-like 55205 - EPT/RTPC-like | 0 | DIRECT |
48371,56112 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
53756,53067 53756 - UDP-Glycosyltransferase/glycogen phosphorylase 53067 - Actin-like ATPase domain | 0 | DIRECT |
55681,50037 55681 - Class II aaRS and biotin synthetases 50037 - C-terminal domain of transcriptional repressors | 0.000131 | DIRECT |
50729,57889 50729 - PH domain-like 57889 - Cysteine-rich domain | 0.0003296 | DIRECT |
57889,57889 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain | 0.002578 | INHERITED FROM: Diacylglycerol kinase |
53223,51735 53223 - Aminoacid dehydrogenase-like, N-terminal domain 51735 - NAD(P)-binding Rossmann-fold domains | 0.01633 | INHERITED FROM: Shikimate kinase |
52540,50447 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins | 1 | INHERITED FROM: Adenylyl-sulfate kinase |
88697,52374 88697 - PUA domain-like 52374 - Nucleotidylyl transferase | 1 | INHERITED FROM: Adenylyl-sulfate kinase |
52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: Polynucleotide 5'-hydroxyl-kinase |
52374,52540 52374 - Nucleotidylyl transferase 52540 - P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: Ribosylnicotinamide kinase || Dephospho-CoA kinase |
53738,53738 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains | 1 | INHERITED FROM: Glucose-1,6-bisphosphate synthase |
50447,50465 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 1 | INHERITED FROM: Adenylyl-sulfate kinase |
53738,55957 53738 - Phosphoglucomutase, first 3 domains 55957 - Phosphoglucomutase, C-terminal domain | 1 | INHERITED FROM: Glucose-1,6-bisphosphate synthase |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
63520,63520 63520 - PTS-regulatory domain, PRD 63520 - PTS-regulatory domain, PRD | 0 | Direct |
47473,57889 47473 - EF-hand 57889 - Cysteine-rich domain | 0 | Direct |
55205,52540 55205 - EPT/RTPC-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
46689,53697 46689 - Homeodomain-like 53697 - SIS domain | 0 | Direct |
54593,53784 54593 - Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase 53784 - Phosphofructokinase | 0 | Direct |
54849,52029 54849 - GroEL-intermediate domain like 52029 - GroEL apical domain-like | 0 | Direct |
64268,49562 64268 - PX domain 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
52540,88697 52540 - P-loop containing nucleoside triphosphate hydrolases 88697 - PUA domain-like | 0 | Direct |
47473,47473 47473 - EF-hand 47473 - EF-hand | 0 | Direct |
52540,53254 52540 - P-loop containing nucleoside triphosphate hydrolases 53254 - Phosphoglycerate mutase-like | 0 | Direct |
51391,53613 51391 - Thiamin phosphate synthase 53613 - Ribokinase-like | 0 | Direct |
82549,101473 82549 - DAK1/DegV-like 101473 - DhaL-like | 0 | Direct |
51569,53223 51569 - Aldolase 53223 - Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
46785,82114 46785 - "Winged helix" DNA-binding domain 82114 - Riboflavin kinase-like | 0 | Direct |
53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain | 0 | Direct |
82185,82185 82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain 82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 0 | Direct |
52540,51569 52540 - P-loop containing nucleoside triphosphate hydrolases 51569 - Aldolase | 0 | Direct |
50465,52540 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
57889,111331 57889 - Cysteine-rich domain 111331 - NAD kinase/diacylglycerol kinase-like | 0 | Direct |
51621,52935 51621 - Phosphoenolpyruvate/pyruvate domain 52935 - PK C-terminal domain-like | 0 | Direct |
49562,48371 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat | 0 | Direct |
53613,48613 53613 - Ribokinase-like 48613 - Heme oxygenase-like | 0 | Direct |
52540,53271 52540 - P-loop containing nucleoside triphosphate hydrolases 53271 - PRTase-like | 0 | Direct |
52935,52009 52935 - PK C-terminal domain-like 52009 - Phosphohistidine domain | 0 | Direct |
52374,82114 52374 - Nucleotidylyl transferase 82114 - Riboflavin kinase-like | 0 | Direct |
56112,64268 56112 - Protein kinase-like (PK-like) 64268 - PX domain | 0 | Direct |
52540,81301 52540 - P-loop containing nucleoside triphosphate hydrolases 81301 - Nucleotidyltransferase | 0 | Direct |
55804,52794 55804 - Phoshotransferase/anion transport protein 52794 - PTS system IIB component-like | 0 | Direct |
63520,52794 63520 - PTS-regulatory domain, PRD 52794 - PTS system IIB component-like | 0 | Direct |
52794,52794 52794 - PTS system IIB component-like 52794 - PTS system IIB component-like | 0 | Direct |
50800,51621 50800 - PK beta-barrel domain-like 51621 - Phosphoenolpyruvate/pyruvate domain | 0 | Direct |
54211,55060 54211 - Ribosomal protein S5 domain 2-like 55060 - GHMP Kinase, C-terminal domain | 0 | Direct |
53784,53784 53784 - Phosphofructokinase 53784 - Phosphofructokinase | 0 | Direct |
56784,52540 56784 - HAD-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
55604,51261 55604 - Glucose permease domain IIB 51261 - Duplicated hybrid motif | 0 | Direct |
52540,57716 52540 - P-loop containing nucleoside triphosphate hydrolases 57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0 | Direct |
52794,55804 52794 - PTS system IIB component-like 55804 - Phoshotransferase/anion transport protein | 0 | Direct |
50037,53067 50037 - C-terminal domain of transcriptional repressors 53067 - Actin-like ATPase domain | 0 | Direct |
56796,55205 56796 - Dehydroquinate synthase-like 55205 - EPT/RTPC-like | 0 | Direct |
48371,56112 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0 | Direct |
53756,53067 53756 - UDP-Glycosyltransferase/glycogen phosphorylase 53067 - Actin-like ATPase domain | 0 | Direct |
55681,50037 55681 - Class II aaRS and biotin synthetases 50037 - C-terminal domain of transcriptional repressors | 0.000131 | Direct |
50729,57889 50729 - PH domain-like 57889 - Cysteine-rich domain | 0.0003296 | Direct |
57889,57889 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain | 0.002578 | Inherited |
53223,51735 53223 - Aminoacid dehydrogenase-like, N-terminal domain 51735 - NAD(P)-binding Rossmann-fold domains | 0.01633 | Inherited |
52540,50447 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins | 1 | Inherited |
88697,52374 88697 - PUA domain-like 52374 - Nucleotidylyl transferase | 1 | Inherited |
52540,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 1 | Inherited |
52374,52540 52374 - Nucleotidylyl transferase 52540 - P-loop containing nucleoside triphosphate hydrolases | 1 | Inherited |
53738,53738 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains | 1 | Inherited |
50447,50465 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 1 | Inherited |
53738,55957 53738 - Phosphoglucomutase, first 3 domains 55957 - Phosphoglucomutase, C-terminal domain | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEO level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57889,57889,111331 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain 111331 - NAD kinase/diacylglycerol kinase-like | 0 | DIRECT |
56796,55205,52540 56796 - Dehydroquinate synthase-like 55205 - EPT/RTPC-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
50800,51621,52935 50800 - PK beta-barrel domain-like 51621 - Phosphoenolpyruvate/pyruvate domain 52935 - PK C-terminal domain-like | 0 | DIRECT |
55681,50037,53067 55681 - Class II aaRS and biotin synthetases 50037 - C-terminal domain of transcriptional repressors 53067 - Actin-like ATPase domain | 0 | DIRECT |
56112,64268,49562 56112 - Protein kinase-like (PK-like) 64268 - PX domain 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
50447,50465,52540 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
49562,48371,56112 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
51569,53223,51735 51569 - Aldolase 53223 - Aminoacid dehydrogenase-like, N-terminal domain 51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
54593,53784,53784 54593 - Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase 53784 - Phosphofructokinase 53784 - Phosphofructokinase | 0 | DIRECT |
51621,52935,52009 51621 - Phosphoenolpyruvate/pyruvate domain 52935 - PK C-terminal domain-like 52009 - Phosphohistidine domain | 0 | DIRECT |
55205,52540,51569 55205 - EPT/RTPC-like 52540 - P-loop containing nucleoside triphosphate hydrolases 51569 - Aldolase | 0 | DIRECT |
52540,51569,53223 52540 - P-loop containing nucleoside triphosphate hydrolases 51569 - Aldolase 53223 - Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
48371,56112,64268 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) 64268 - PX domain | 0 | DIRECT |
63520,52794,55804 63520 - PTS-regulatory domain, PRD 52794 - PTS system IIB component-like 55804 - Phoshotransferase/anion transport protein | 0 | DIRECT |
52540,88697,52374 52540 - P-loop containing nucleoside triphosphate hydrolases 88697 - PUA domain-like 52374 - Nucleotidylyl transferase | 0 | DIRECT |
63520,63520,52794 63520 - PTS-regulatory domain, PRD 63520 - PTS-regulatory domain, PRD 52794 - PTS system IIB component-like | 0 | DIRECT |
47473,57889,57889 47473 - EF-hand 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain | 0 | DIRECT |
47473,47473,57889 47473 - EF-hand 47473 - EF-hand 57889 - Cysteine-rich domain | 0 | DIRECT |
50037,53067,53067 50037 - C-terminal domain of transcriptional repressors 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain | 0 | DIRECT |
50729,57889,57889 50729 - PH domain-like 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain | 0 | DIRECT |
53067,53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain | 0.0000000000766 | DIRECT |
53738,53738,55957 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains 55957 - Phosphoglucomutase, C-terminal domain | 1 | INHERITED FROM: Glucose-1,6-bisphosphate synthase |
53738,53738,53738 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains | 1 | INHERITED FROM: Glucose-1,6-bisphosphate synthase |
52540,50447,50465 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 1 | INHERITED FROM: Adenylyl-sulfate kinase |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57889,57889,111331 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain 111331 - NAD kinase/diacylglycerol kinase-like | 0 | Direct |
56796,55205,52540 56796 - Dehydroquinate synthase-like 55205 - EPT/RTPC-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
50800,51621,52935 50800 - PK beta-barrel domain-like 51621 - Phosphoenolpyruvate/pyruvate domain 52935 - PK C-terminal domain-like | 0 | Direct |
55681,50037,53067 55681 - Class II aaRS and biotin synthetases 50037 - C-terminal domain of transcriptional repressors 53067 - Actin-like ATPase domain | 0 | Direct |
56112,64268,49562 56112 - Protein kinase-like (PK-like) 64268 - PX domain 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
50447,50465,52540 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
49562,48371,56112 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0 | Direct |
51569,53223,51735 51569 - Aldolase 53223 - Aminoacid dehydrogenase-like, N-terminal domain 51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
54593,53784,53784 54593 - Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase 53784 - Phosphofructokinase 53784 - Phosphofructokinase | 0 | Direct |
51621,52935,52009 51621 - Phosphoenolpyruvate/pyruvate domain 52935 - PK C-terminal domain-like 52009 - Phosphohistidine domain | 0 | Direct |
55205,52540,51569 55205 - EPT/RTPC-like 52540 - P-loop containing nucleoside triphosphate hydrolases 51569 - Aldolase | 0 | Direct |
52540,51569,53223 52540 - P-loop containing nucleoside triphosphate hydrolases 51569 - Aldolase 53223 - Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
48371,56112,64268 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) 64268 - PX domain | 0 | Direct |
63520,52794,55804 63520 - PTS-regulatory domain, PRD 52794 - PTS system IIB component-like 55804 - Phoshotransferase/anion transport protein | 0 | Direct |
52540,88697,52374 52540 - P-loop containing nucleoside triphosphate hydrolases 88697 - PUA domain-like 52374 - Nucleotidylyl transferase | 0 | Direct |
63520,63520,52794 63520 - PTS-regulatory domain, PRD 63520 - PTS-regulatory domain, PRD 52794 - PTS system IIB component-like | 0 | Direct |
47473,57889,57889 47473 - EF-hand 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain | 0 | Direct |
47473,47473,57889 47473 - EF-hand 47473 - EF-hand 57889 - Cysteine-rich domain | 0 | Direct |
50037,53067,53067 50037 - C-terminal domain of transcriptional repressors 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain | 0 | Direct |
50729,57889,57889 50729 - PH domain-like 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain | 0 | Direct |
53067,53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain | 0.0000000000766 | Direct |
53738,53738,55957 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains 55957 - Phosphoglucomutase, C-terminal domain | 1 | Inherited |
53738,53738,53738 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains | 1 | Inherited |
52540,50447,50465 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 1 | Inherited |
Plot distribution on phylogenetic tree for Individual Supra-domains annotated by this EC term
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A presence/absence matrix is generated using protein domains and supradomains
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