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Phosphoric monoester hydrolases
(show info)
Enzyme Commission (EC)
Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed. To navigate hierarchical structure of EC, we display all parental EC terms to the current EC term of interest ordered by their shortest distances to the current term. Also, only direct children EC terms of the current EC term are listed.
Structural Classification of Proteins (SCOP)
SCOP classifies evolutionary-related domains into Superfamily level and Family level. Accordingly, we have generated the domain-centric EC annotations for each of the three concepts at each of the two domain levels.
Structural Domain Enzyme Commission Ontology (SDEO)
As domain-centric ontology, SDEO only refers to those EC terms which are the most informative to annotate SCOP domains.
EC annotations for SCOP domains
For details, please visit Documentation: EC annotations for SCOP domains. Therein, we provide several relevant files ( Data Availability) for the download, including an annotation file (i.e., Domain2EC.txt) and the corresponding ontology (i.e., SDEO.txt).
Supra-domain Enzyme Commission Ontology (SPEO)
As an extension, SPEO includes those EC terms which are the most informative to annotate supra-domains and individual SCOP domains at the Superfamily level.
EC annotations for Supra-domains
For details, please visit Documentation: EC annotations for Supra-domains. Therein, we provide several relevant files ( Data Availability) for the download, including a annotation file (i.e., SP2EC.txt) and an ontology (i.e., SPEO.txt). For the sake of being browsable, listed below are those supra-domains (single, dual, triple, quad).
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Root: EC Hierarchy (from IntEnz release 70)
| Shortest distance to current term (+ for parents, - for children) |
EC term [EC ID] <#Children> |
(#SF|#FA) |
#Supra-domain (Single|Duplex|Triple) |
| + + + 3: | root [root] <6> |
| + + 2: | Hydrolases [3] <13> | (329|528) |
(368|389|207) |
| + 1: | Acting on ester bonds [3.1] <20> | (124|170) |
(142|112|48) |
| 0: | Phosphoric monoester hydrolases [3.1.3] <90> | (44|59) |
(55|43|12) |
| - 1: | 2,3-bisphosphoglycerate 3-phosphatase [3.1.3.80] | (0|0) |
(1|0|0) |
| - 1: | 2-carboxy-D-arabinitol-1-phosphatase [3.1.3.63] | (0|0) |
(0|0|0) |
| - 1: | 2-deoxyglucose-6-phosphatase [3.1.3.68] | (0|0) |
(0|0|0) |
| - 1: | 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate [3.1.3.n4] | (1|1) |
(0|0|0) |
| - 1: | 2-phosphosulfolactate phosphatase [3.1.3.71] | (1|1) |
(1|0|0) |
| - 1: | 3'(2'),5'-bisphosphate nucleotidase [3.1.3.7] | (1|1) |
(1|0|0) |
| - 1: | 3'-nucleotidase [3.1.3.6] | (2|3) |
(2|1|0) |
| - 1: | 3-deoxy-manno-octulosonate-8-phosphatase [3.1.3.45] | (1|1) |
(1|0|0) |
| - 1: | 3-phosphoglycerate phosphatase [3.1.3.38] | (0|0) |
(0|0|0) |
| - 1: | 3-phytase [3.1.3.8] | (1|1) |
(2|0|0) |
| - 1: | 4-nitrophenylphosphatase [3.1.3.41] | (0|0) |
(0|0|0) |
| - 1: | 4-phytase [3.1.3.26] | (0|0) |
(0|0|0) |
| - 1: | 5'-nucleotidase [3.1.3.5] | (2|5) |
(2|1|0) |
| - 1: | 5-phytase [3.1.3.72] | (0|0) |
(0|0|0) |
| - 1: | ADP-phosphoglycerate phosphatase [3.1.3.28] | (0|0) |
(0|0|0) |
| - 1: | ADP-ribose 1''-phosphate phosphatase [3.1.3.84] | (1|1) |
(1|0|0) |
| - 1: | Acid phosphatase [3.1.3.2] | (4|6) |
(4|1|0) |
| - 1: | Acireductone synthase [3.1.3.77] | (2|2) |
(2|1|0) |
| - 1: | Adenosylcobalamin/alpha-ribazole phosphatase [3.1.3.73] | (0|0) |
(1|0|0) |
| - 1: | Alkaline phosphatase [3.1.3.1] | (1|1) |
(1|0|0) |
| - 1: | Alkylacetylglycerophosphatase [3.1.3.59] | (0|0) |
(0|0|0) |
| - 1: | Bisphosphoglycerate phosphatase [3.1.3.13] | (1|1) |
(1|0|0) |
| - 1: | Caldesmon-phosphatase [3.1.3.55] | (0|0) |
(0|0|0) |
| - 1: | D-glycero-alpha-D-manno-heptose-1,7-bisphosphate 7 [3.1.3.83] | (0|0) |
(0|0|0) |
| - 1: | D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7- [3.1.3.82] | (0|0) |
(0|0|0) |
| - 1: | Deleted entry [3.1.3.61] | (0|0) |
(0|0|0) |
| - 1: | Deoxynucleotide 3'-phosphatase [3.1.3.34] | (0|0) |
(0|0|0) |
| - 1: | Diacylglycerol diphosphate phosphatase [3.1.3.81] | (0|0) |
(0|0|0) |
| - 1: | Dolichyl-phosphatase [3.1.3.51] | (0|0) |
(0|0|0) |
| - 1: | Fructose-2,6-bisphosphate 2-phosphatase [3.1.3.46] | (2|3) |
(2|1|0) |
| - 1: | Fructose-2,6-bisphosphate 6-phosphatase [3.1.3.54] | (0|0) |
(0|0|0) |
| - 1: | Fructose-bisphosphatase [3.1.3.11] | (1|2) |
(1|1|0) |
| - 1: | Glucose-1-phosphatase [3.1.3.10] | (0|0) |
(1|0|0) |
| - 1: | Glucose-6-phosphatase [3.1.3.9] | (1|0) |
(1|0|0) |
| - 1: | Glucosyl-3-phosphoglycerate phosphatase [3.1.3.85] | (0|0) |
(0|0|0) |
| - 1: | Glucosylglycerol 3-phosphatase [3.1.3.69] | (0|0) |
(0|0|0) |
| - 1: | Glycerol-1-phosphatase [3.1.3.21] | (0|0) |
(0|0|0) |
| - 1: | Glycerol-2-phosphatase [3.1.3.19] | (0|0) |
(0|0|0) |
| - 1: | Guanidinodeoxy-scyllo-inositol-4-phosphatase [3.1.3.40] | (0|0) |
(0|0|0) |
| - 1: | Histidinol-phosphatase [3.1.3.15] | (3|2) |
(3|2|1) |
| - 1: | Inositol-1,4-bisphosphate 1-phosphatase [3.1.3.57] | (1|1) |
(1|0|0) |
| - 1: | Inositol-phosphate phosphatase [3.1.3.25] | (1|1) |
(1|0|0) |
| - 1: | Inositol-polyphosphate 5-phosphatase [3.1.3.56] | (1|1) |
(1|0|0) |
| - 1: | Lipid-phosphate phosphatase [3.1.3.76] | (0|0) |
(0|0|0) |
| - 1: | Mannitol-1-phosphatase [3.1.3.22] | (0|0) |
(0|0|0) |
| - 1: | Mannosyl-3-phosphoglycerate phosphatase [3.1.3.70] | (1|1) |
(1|0|0) |
| - 1: | Mannosylfructose-phosphate phosphatase [3.1.3.79] | (0|0) |
(0|0|0) |
| - 1: | Methylphosphothioglycerate phosphatase [3.1.3.14] | (0|0) |
(0|0|0) |
| - 1: | Multiple inositol-polyphosphate phosphatase [3.1.3.62] | (0|0) |
(1|0|0) |
| - 1: | N-acylneuraminate-9-phosphatase [3.1.3.29] | (0|0) |
(0|0|0) |
| - 1: | Nucleotidase [3.1.3.31] | (0|0) |
(0|0|0) |
| - 1: | Phosphatidate phosphatase [3.1.3.4] | (1|0) |
(1|0|0) |
| - 1: | Phosphatidylglycerophosphatase [3.1.3.27] | (0|0) |
(0|0|0) |
| - 1: | Phosphatidylinositol-3,4,5-trisphosphate 3-phospha [3.1.3.67] | (2|2) |
(2|1|0) |
| - 1: | Phosphatidylinositol-3,4,5-trisphosphate 5-phospha [3.1.3.86] | (3|3) |
(3|0|0) |
| - 1: | Phosphatidylinositol-3,4-bisphosphate 4-phosphatas [3.1.3.66] | (1|0) |
(1|0|0) |
| - 1: | Phosphatidylinositol-3-phosphatase [3.1.3.64] | (2|2) |
(2|1|0) |
| - 1: | Phosphatidylinositol-4,5-bisphosphate 4-phosphatas [3.1.3.78] | (0|0) |
(0|0|0) |
| - 1: | Phosphoenolpyruvate phosphatase [3.1.3.60] | (0|0) |
(0|0|0) |
| - 1: | Phosphoethanolamine/phosphocholine phosphatase [3.1.3.75] | (0|0) |
(0|0|0) |
| - 1: | Phosphoglycerate phosphatase [3.1.3.20] | (0|0) |
(0|0|0) |
| - 1: | Phosphoglycolate phosphatase [3.1.3.18] | (1|2) |
(1|0|0) |
| - 1: | Phosphoinositide 5-phosphatase [3.1.3.36] | (2|2) |
(3|1|0) |
| - 1: | Phosphoprotein phosphatase [3.1.3.16] | (10|10) |
(11|8|0) |
| - 1: | Phosphoserine phosphatase [3.1.3.3] | (1|2) |
(1|0|0) |
| - 1: | Polynucleotide 3'-phosphatase [3.1.3.32] | (1|0) |
(2|1|0) |
| - 1: | Polynucleotide 5'-phosphatase [3.1.3.33] | (6|2) |
(6|4|1) |
| - 1: | Protein-tyrosine-phosphatase [3.1.3.48] | (14|16) |
(21|19|9) |
| - 1: | Pyridoxal phosphatase [3.1.3.74] | (1|0) |
(1|0|0) |
| - 1: | Sedoheptulose-bisphosphatase [3.1.3.37] | (1|1) |
(1|0|0) |
| - 1: | Sorbitol-6-phosphatase [3.1.3.50] | (0|0) |
(0|0|0) |
| - 1: | Streptomycin-6-phosphatase [3.1.3.39] | (0|0) |
(0|0|0) |
| - 1: | Sucrose-phosphate phosphatase [3.1.3.24] | (2|1) |
(2|1|0) |
| - 1: | Sugar-phosphatase [3.1.3.23] | (0|0) |
(1|0|0) |
| - 1: | Sugar-terminal-phosphatase [3.1.3.58] | (0|0) |
(0|0|0) |
| - 1: | Thymidylate 5'-phosphatase [3.1.3.35] | (0|0) |
(0|0|0) |
| - 1: | Transferred entry: 3.1.3.31 [3.1.3.30] | (0|0) |
(0|0|0) |
| - 1: | Transferred entry: 3.1.3.64 [3.1.3.65] | (0|0) |
(0|0|0) |
| - 1: | Transferred entry: 3.1.3.78 [3.1.3.n3] | (0|0) |
(0|0|0) |
| - 1: | Transferred entry: 3.1.3.84 [3.1.3.n2] | (0|0) |
(0|0|0) |
| - 1: | Transferred entry: 3.1.3.86 [3.1.3.n1] | (0|0) |
(0|0|0) |
| - 1: | Trehalose-phosphatase [3.1.3.12] | (1|1) |
(2|2|0) |
| - 1: | [Acetyl-CoA carboxylase]-phosphatase [3.1.3.44] | (0|0) |
(0|0|0) |
| - 1: | [Glycogen-synthase-D] phosphatase [3.1.3.42] | (0|0) |
(0|0|0) |
| - 1: | [Hydroxymethylglutaryl-CoA reductase (NADPH)]-phos [3.1.3.47] | (0|0) |
(0|0|0) |
| - 1: | [Myosin-light-chain] phosphatase [3.1.3.53] | (0|0) |
(0|0|0) |
| - 1: | [Phosphorylase] phosphatase [3.1.3.17] | (0|0) |
(0|0|0) |
| - 1: | [Pyruvate dehydrogenase (acetyl-transferring)]-pho [3.1.3.43] | (1|1) |
(1|0|0) |
| - 1: | [Pyruvate kinase]-phosphatase [3.1.3.49] | (0|0) |
(0|0|0) |
| - 1: | phosphatase [3.1.3.52] | (0|0) |
(0|0|0) |
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this EC term (SDEO level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| Carbohydrate phosphatase | 0 | DIRECT |
| Purple acid phosphatase, N-terminal domain | 0 | DIRECT |
| Fibronectin type III | 0 | DIRECT |
| Macro domain-like | 0 | DIRECT |
| (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
| Phosphoglycerate mutase-like | 0 | DIRECT |
| HAD-like | 0 | DIRECT |
| Phosphotyrosine protein phosphatases I | 0 | DIRECT |
| Metallo-dependent phosphatases | 0 | DIRECT |
| 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain | 0 | DIRECT |
| SurE-like | 0 | DIRECT |
| Rhodanese/Cell cycle control phosphatase | 0 | DIRECT |
| ComB-like | 0 | DIRECT |
| Protein serine/threonine phosphatase 2C, C-terminal domain | 0 | DIRECT |
| PP2C-like | 0 | DIRECT |
| Acid phosphatase/Vanadium-dependent haloperoxidase | 0 | DIRECT |
| CYTH-like phosphatases | 9.368e-16 | DIRECT |
| Immunoglobulin | 0.0000000000000076 | DIRECT |
| Second domain of FERM | 0.000000000000007826 | DIRECT |
| DEK C-terminal domain | 0.0000000000001604 | DIRECT |
| Ubiquitin-like | 0.0000000004443 | DIRECT |
| NTF2-like | 0.000000002583 | DIRECT |
| SH2 domain | 0.000002804 | DIRECT |
| Kelch motif | 0.000004386 | DIRECT |
| PDZ domain-like | 0.0004756 | DIRECT |
| FYVE/PHD zinc finger | 0.0005085 | DIRECT |
| TPR-like | 0.0012 | INHERITED FROM: Phosphoprotein phosphatase |
| AraD/HMP-PK domain-like | 0.003305 | INHERITED FROM: Acireductone synthase |
| DNase I-like | 0.004367 | INHERITED FROM: Phosphoinositide 5-phosphatase || Inositol-polyphosphate 5-phosphatase || Phosphatidylinositol-3,4,5-trisphosphate 5-phospha |
| Carbonic anhydrase | 0.004856 | INHERITED FROM: Protein-tyrosine-phosphatase |
| SAM/Pointed domain | 0.007561 | INHERITED FROM: Phosphatidylinositol-3,4,5-trisphosphate 5-phospha |
| RNA-binding domain, RBD | 0.02062 | INHERITED FROM: Phosphoinositide 5-phosphatase |
| PH domain-like | 0.05493 | INHERITED FROM: Phosphatidylinositol-3-phosphatase || Protein-tyrosine-phosphatase |
| Concanavalin A-like lectins/glucanases | 0.07915 | INHERITED FROM: Protein-tyrosine-phosphatase |
| Alkaline phosphatase-like | 0.1016 | INHERITED FROM: Alkaline phosphatase |
| L domain-like | 0.3857 | INHERITED FROM: Phosphoprotein phosphatase |
| PHP domain-like | 0.7215 | INHERITED FROM: Histidinol-phosphatase |
| EF-hand | 1 | INHERITED FROM: Phosphoprotein phosphatase |
| DNA/RNA polymerases | 1 | INHERITED FROM: Polynucleotide 5'-phosphatase |
| P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: Polynucleotide 5'-phosphatase || Fructose-2,6-bisphosphate 2-phosphatase |
| S-adenosyl-L-methionine-dependent methyltransferases | 1 | INHERITED FROM: Polynucleotide 5'-phosphatase |
| Ribosomal protein S5 domain 2-like | 1 | INHERITED FROM: Histidinol-phosphatase |
| DNA ligase/mRNA capping enzyme, catalytic domain | 1 | INHERITED FROM: Polynucleotide 5'-phosphatase |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 1 | INHERITED FROM: Phosphatidylinositol-3,4,5-trisphosphate 3-phospha || Phosphatidylinositol-3,4-bisphosphate 4-phosphatas |
Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this (SDEO level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain | 0 | DIRECT |
| Pyrimidine 5'-nucleotidase (UMPH-1) | 0 | DIRECT |
| Type 2 phosphatidic acid phosphatase, PAP2 | 0 | DIRECT |
| 5'-nucleotidase (syn. UDP-sugar hydrolase), N-terminal domain | 0 | DIRECT |
| GlpX-like bacterial fructose-1,6-bisphosphatase | 0 | DIRECT |
| Phosphoserine phosphatase | 0 | DIRECT |
| YfcE-like | 0 | DIRECT |
| 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain | 0 | DIRECT |
| Higher-molecular-weight phosphotyrosine protein phosphatases | 0 | DIRECT |
| Protein serine/threonine phosphatase | 0 | DIRECT |
| Histidinol phosphatase-like | 0 | DIRECT |
| Fibronectin type III | 0 | DIRECT |
| Inositol monophosphatase/fructose-1,6-bisphosphatase-like | 0 | DIRECT |
| MtnX-like | 0 | DIRECT |
| Myotubularin-like phosphatases | 0 | DIRECT |
| beta-Phosphoglucomutase-like | 0 | DIRECT |
| Enolase-phosphatase E1 | 0 | DIRECT |
| Purple acid phosphatase, N-terminal domain | 0 | DIRECT |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain | 0 | DIRECT |
| SurE-like | 0 | DIRECT |
| Low-molecular-weight phosphotyrosine protein phosphatases | 0 | DIRECT |
| mRNA triphosphatase CET1 | 0 | DIRECT |
| Protein serine/threonine phosphatase 2C, C-terminal domain | 0 | DIRECT |
| ComB-like | 0 | DIRECT |
| Trehalose-phosphatase | 0 | DIRECT |
| 5' nucleotidase-like | 0 | DIRECT |
| PP2C-like | 0 | DIRECT |
| Macro domain | 0 | DIRECT |
| Predicted hydrolases Cof | 0 | DIRECT |
| I set domains | 0 | DIRECT |
| Alkaline phosphatase | 0 | DIRECT |
| Third domain of FERM | 0 | DIRECT |
| Dual specificity phosphatase-like | 0 | DIRECT |
| Leucine rich effector protein YopM | 0 | DIRECT |
| Purple acid phosphatase-like | 0 | DIRECT |
| Histidine acid phosphatase | 0 | DIRECT |
| Class B acid phosphatase, AphA | 0 | DIRECT |
| NLI interacting factor-like phosphatase | 0 | DIRECT |
| Imidazole glycerol phosphate dehydratase | 0 | DIRECT |
| GRAM domain | 0 | DIRECT |
| Inositol polyphosphate 5-phosphatase (IPP5) | 0 | DIRECT |
| Cell cycle control phosphatase, catalytic domain | 0 | DIRECT |
| NagD-like | 3.476e-16 | DIRECT |
| First domain of FERM | 0.000000000000001897 | DIRECT |
| Second domain of FERM | 0.000000000000003089 | DIRECT |
| MAM domain | 0.00000000000001969 | DIRECT |
| Ubiquitin-related | 0.000000000005677 | DIRECT |
| FYVE, a phosphatidylinositol-3-phosphate binding domain | 0.00000000003237 | DIRECT |
| Cofactor-dependent phosphoglycerate mutase | 0.0000000002092 | DIRECT |
| PDZ domain | 0.0000000002457 | DIRECT |
| DEK C-terminal domain | 0.0000000002661 | DIRECT |
| Probable phosphatase YrbI | 0.0000000004881 | DIRECT |
| SH2 domain | 0.00000292 | DIRECT |
| Tetratricopeptide repeat (TPR) | 0.00001861 | DIRECT |
| SAM (sterile alpha motif) domain | 0.002052 | INHERITED FROM: Phosphatidylinositol-3,4,5-trisphosphate 5-phospha |
| AraD-like aldolase/epimerase | 0.002319 | INHERITED FROM: Acireductone synthase |
| Carbonic anhydrase | 0.003902 | INHERITED FROM: Protein-tyrosine-phosphatase |
| Canonical RBD | 0.0196 | INHERITED FROM: Phosphoinositide 5-phosphatase |
| PLC-like (P variant) | 1 | INHERITED FROM: Phosphatidylinositol-3,4,5-trisphosphate 3-phospha || Protein-tyrosine-phosphatase |
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain | 0 | Direct |
| Pyrimidine 5'-nucleotidase (UMPH-1) | 0 | Direct |
| Type 2 phosphatidic acid phosphatase, PAP2 | 0 | Direct |
| 5'-nucleotidase (syn. UDP-sugar hydrolase), N-terminal domain | 0 | Direct |
| GlpX-like bacterial fructose-1,6-bisphosphatase | 0 | Direct |
| Phosphoserine phosphatase | 0 | Direct |
| YfcE-like | 0 | Direct |
| 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain | 0 | Direct |
| Higher-molecular-weight phosphotyrosine protein phosphatases | 0 | Direct |
| Protein serine/threonine phosphatase | 0 | Direct |
| Histidinol phosphatase-like | 0 | Direct |
| Fibronectin type III | 0 | Direct |
| Inositol monophosphatase/fructose-1,6-bisphosphatase-like | 0 | Direct |
| MtnX-like | 0 | Direct |
| Myotubularin-like phosphatases | 0 | Direct |
| beta-Phosphoglucomutase-like | 0 | Direct |
| Enolase-phosphatase E1 | 0 | Direct |
| Purple acid phosphatase, N-terminal domain | 0 | Direct |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain | 0 | Direct |
| SurE-like | 0 | Direct |
| Low-molecular-weight phosphotyrosine protein phosphatases | 0 | Direct |
| mRNA triphosphatase CET1 | 0 | Direct |
| Protein serine/threonine phosphatase 2C, C-terminal domain | 0 | Direct |
| ComB-like | 0 | Direct |
| Trehalose-phosphatase | 0 | Direct |
| 5' nucleotidase-like | 0 | Direct |
| PP2C-like | 0 | Direct |
| Macro domain | 0 | Direct |
| Predicted hydrolases Cof | 0 | Direct |
| I set domains | 0 | Direct |
| Alkaline phosphatase | 0 | Direct |
| Third domain of FERM | 0 | Direct |
| Dual specificity phosphatase-like | 0 | Direct |
| Leucine rich effector protein YopM | 0 | Direct |
| Purple acid phosphatase-like | 0 | Direct |
| Histidine acid phosphatase | 0 | Direct |
| Class B acid phosphatase, AphA | 0 | Direct |
| NLI interacting factor-like phosphatase | 0 | Direct |
| Imidazole glycerol phosphate dehydratase | 0 | Direct |
| GRAM domain | 0 | Direct |
| Inositol polyphosphate 5-phosphatase (IPP5) | 0 | Direct |
| Cell cycle control phosphatase, catalytic domain | 0 | Direct |
| NagD-like | 3.476e-16 | Direct |
| First domain of FERM | 0.000000000000001897 | Direct |
| Second domain of FERM | 0.000000000000003089 | Direct |
| MAM domain | 0.00000000000001969 | Direct |
| Ubiquitin-related | 0.000000000005677 | Direct |
| FYVE, a phosphatidylinositol-3-phosphate binding domain | 0.00000000003237 | Direct |
| Cofactor-dependent phosphoglycerate mutase | 0.0000000002092 | Direct |
| PDZ domain | 0.0000000002457 | Direct |
| DEK C-terminal domain | 0.0000000002661 | Direct |
| Probable phosphatase YrbI | 0.0000000004881 | Direct |
| SH2 domain | 0.00000292 | Direct |
| Tetratricopeptide repeat (TPR) | 0.00001861 | Direct |
| SAM (sterile alpha motif) domain | 0.002052 | Inherited |
| AraD-like aldolase/epimerase | 0.002319 | Inherited |
| Carbonic anhydrase | 0.003902 | Inherited |
| Canonical RBD | 0.0196 | Inherited |
| PLC-like (P variant) | 1 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this EC term
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A presence/absence matrix is generated using protein domains and supradomains
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Jump to [ Top · EC Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this EC term (SPEO level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| PP2C-like | 0 | DIRECT |
| Voltage-gated potassium channels | 0 | DIRECT |
| Phosphoglycerate mutase-like | 0 | DIRECT |
| Bacterial GAP domain | 0 | DIRECT |
| Carbohydrate phosphatase | 0 | DIRECT |
| 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain | 0 | DIRECT |
| CRAL/TRIO N-terminal domain | 0 | DIRECT |
| HAD-like | 0 | DIRECT |
| Protein serine/threonine phosphatase 2C, C-terminal domain | 0 | DIRECT |
| Metallo-dependent phosphatases | 0 | DIRECT |
| (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
| Rhodanese/Cell cycle control phosphatase | 0 | DIRECT |
| Fibronectin type III | 0 | DIRECT |
| Purple acid phosphatase, N-terminal domain | 0 | DIRECT |
| CYTH-like phosphatases | 0 | DIRECT |
| Macro domain-like | 0 | DIRECT |
| ComB-like | 0 | DIRECT |
| Phosphotyrosine protein phosphatases I | 0 | DIRECT |
| Acid phosphatase/Vanadium-dependent haloperoxidase | 0 | DIRECT |
| SurE-like | 0 | DIRECT |
| Second domain of FERM | 0.000000000000006742 | DIRECT |
| Immunoglobulin | 0.000000000000007259 | DIRECT |
| DEK C-terminal domain | 0.000000000000132 | DIRECT |
| Ubiquitin-like | 0.000000000418 | DIRECT |
| NTF2-like | 0.000000002297 | DIRECT |
| Chaperone J-domain | 0.000001912 | DIRECT |
| GTPase activation domain, GAP | 0.000001912 | DIRECT |
| SH2 domain | 0.000002646 | DIRECT |
| Kelch motif | 0.000003858 | DIRECT |
| CRAL/TRIO domain | 0.00001505 | DIRECT |
| SMAD/FHA domain | 0.0001833 | DIRECT |
| Non-globular alpha+beta subunits of globular proteins | 0.0003093 | DIRECT |
| PDZ domain-like | 0.000432 | DIRECT |
| FYVE/PHD zinc finger | 0.0004628 | DIRECT |
| TPR-like | 0.001103 | INHERITED FROM: Phosphoprotein phosphatase |
| AraD/HMP-PK domain-like | 0.003095 | INHERITED FROM: Acireductone synthase |
| DNase I-like | 0.003662 | INHERITED FROM: Phosphoinositide 5-phosphatase || Inositol-polyphosphate 5-phosphatase || Phosphatidylinositol-3,4,5-trisphosphate 5-phospha |
| Carbonic anhydrase | 0.004418 | INHERITED FROM: Protein-tyrosine-phosphatase |
| SAM/Pointed domain | 0.006901 | INHERITED FROM: Phosphatidylinositol-3,4,5-trisphosphate 5-phospha |
| Starch-binding domain-like | 0.01214 | INHERITED FROM: Protein-tyrosine-phosphatase || Phosphoprotein phosphatase |
| RNA-binding domain, RBD | 0.01912 | INHERITED FROM: Phosphoinositide 5-phosphatase |
| Thermostable phytase (3-phytase) | 0.03371 | INHERITED FROM: 3-phytase |
| PH domain-like | 0.05457 | INHERITED FROM: Phosphatidylinositol-3-phosphatase || Protein-tyrosine-phosphatase |
| Concanavalin A-like lectins/glucanases | 0.07729 | INHERITED FROM: Protein-tyrosine-phosphatase |
| Alkaline phosphatase-like | 0.09987 | INHERITED FROM: Alkaline phosphatase |
| L domain-like | 0.3697 | INHERITED FROM: Phosphoprotein phosphatase |
| PHP domain-like | 0.6917 | INHERITED FROM: Histidinol-phosphatase |
| DNA ligase/mRNA capping enzyme, catalytic domain | 1 | INHERITED FROM: Polynucleotide 5'-phosphatase |
| EF-hand | 1 | INHERITED FROM: Phosphoprotein phosphatase |
| UDP-Glycosyltransferase/glycogen phosphorylase | 1 | INHERITED FROM: Trehalose-phosphatase |
| S-adenosyl-L-methionine-dependent methyltransferases | 1 | INHERITED FROM: Polynucleotide 5'-phosphatase |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 1 | INHERITED FROM: Phosphatidylinositol-3,4,5-trisphosphate 3-phospha || Protein-tyrosine-phosphatase || Phosphatidylinositol-3,4-bisphosphate 4-phosphatas |
| P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: Polynucleotide 5'-phosphatase || Fructose-2,6-bisphosphate 2-phosphatase || Polynucleotide 3'-phosphatase |
| Ribosomal protein S5 domain 2-like | 1 | INHERITED FROM: Histidinol-phosphatase |
| DNA/RNA polymerases | 1 | INHERITED FROM: Polynucleotide 5'-phosphatase |
(show details)
Supra-domains annotated to this EC term (SPEO level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
56219,54928
56219 - DNase I-like
54928 - RNA-binding domain, RBD | 0 | DIRECT |
56784,54427
56784 - HAD-like
54427 - NTF2-like | 0 | DIRECT |
50156,52799
50156 - PDZ domain-like
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
46938,52087
46938 - CRAL/TRIO N-terminal domain
52087 - CRAL/TRIO domain | 0 | DIRECT |
48452,56300
48452 - TPR-like
56300 - Metallo-dependent phosphatases | 0 | DIRECT |
81324,52799
81324 - Voltage-gated potassium channels
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
56784,54211
56784 - HAD-like
54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
81606,81601
81606 - PP2C-like
81601 - Protein serine/threonine phosphatase 2C, C-terminal domain | 0 | DIRECT |
52540,53254
52540 - P-loop containing nucleoside triphosphate hydrolases
53254 - Phosphoglycerate mutase-like | 0 | DIRECT |
101908,56219
101908 - Putative isomerase YbhE
56219 - DNase I-like | 0 | DIRECT |
56784,56784
56784 - HAD-like
56784 - HAD-like | 0 | DIRECT |
47233,52799
47233 - Bacterial GAP domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
49363,56300
49363 - Purple acid phosphatase, N-terminal domain
56300 - Metallo-dependent phosphatases | 0 | DIRECT |
49452,52799
49452 - Starch-binding domain-like
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
49899,48726
49899 - Concanavalin A-like lectins/glucanases
48726 - Immunoglobulin | 0 | DIRECT |
52799,52799
52799 - (Phosphotyrosine protein) phosphatases II
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
52799,56091
52799 - (Phosphotyrosine protein) phosphatases II
56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
53639,56784
53639 - AraD/HMP-PK domain-like
56784 - HAD-like | 0 | DIRECT |
51069,49265
51069 - Carbonic anhydrase
49265 - Fibronectin type III | 0 | DIRECT |
52799,49562
52799 - (Phosphotyrosine protein) phosphatases II
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
52821,52799
52821 - Rhodanese/Cell cycle control phosphatase
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
52087,52799
52087 - CRAL/TRIO domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0 | DIRECT |
55550,52799
55550 - SH2 domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
56300,47473
56300 - Metallo-dependent phosphatases
47473 - EF-hand | 0 | DIRECT |
54211,54211
54211 - Ribosomal protein S5 domain 2-like
54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
56300,56300
56300 - Metallo-dependent phosphatases
56300 - Metallo-dependent phosphatases | 0 | DIRECT |
56784,52540
56784 - HAD-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
54236,56784
54236 - Ubiquitin-like
56784 - HAD-like | 0 | DIRECT |
54236,47031
54236 - Ubiquitin-like
47031 - Second domain of FERM | 0 | DIRECT |
50729,52799
50729 - PH domain-like
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0 | DIRECT |
55154,56091
55154 - CYTH-like phosphatases
56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
56300,55816
56300 - Metallo-dependent phosphatases
55816 - 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain | 0 | DIRECT |
109715,52799
109715 - DEK C-terminal domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
56568,47233
56568 - Non-globular alpha+beta subunits of globular proteins
47233 - Bacterial GAP domain | 0 | DIRECT |
47031,50729
47031 - Second domain of FERM
50729 - PH domain-like | 3.502e-16 | DIRECT |
53335,52949
53335 - S-adenosyl-L-methionine-dependent methyltransferases
52949 - Macro domain-like | 0.00000000000001513 | DIRECT |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.0000007029 | DIRECT |
53756,56784
53756 - UDP-Glycosyltransferase/glycogen phosphorylase
56784 - HAD-like | 0.00003603 | DIRECT |
52058,52058
52058 - L domain-like
52058 - L domain-like | 0.00007151 | DIRECT |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0.01584 | INHERITED FROM: Protein-tyrosine-phosphatase |
56091,50249
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 1 | INHERITED FROM: Polynucleotide 5'-phosphatase |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
56219,54928
56219 - DNase I-like
54928 - RNA-binding domain, RBD | 0 | Direct |
56784,54427
56784 - HAD-like
54427 - NTF2-like | 0 | Direct |
50156,52799
50156 - PDZ domain-like
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
46938,52087
46938 - CRAL/TRIO N-terminal domain
52087 - CRAL/TRIO domain | 0 | Direct |
48452,56300
48452 - TPR-like
56300 - Metallo-dependent phosphatases | 0 | Direct |
81324,52799
81324 - Voltage-gated potassium channels
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
56784,54211
56784 - HAD-like
54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
81606,81601
81606 - PP2C-like
81601 - Protein serine/threonine phosphatase 2C, C-terminal domain | 0 | Direct |
52540,53254
52540 - P-loop containing nucleoside triphosphate hydrolases
53254 - Phosphoglycerate mutase-like | 0 | Direct |
101908,56219
101908 - Putative isomerase YbhE
56219 - DNase I-like | 0 | Direct |
56784,56784
56784 - HAD-like
56784 - HAD-like | 0 | Direct |
47233,52799
47233 - Bacterial GAP domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
49363,56300
49363 - Purple acid phosphatase, N-terminal domain
56300 - Metallo-dependent phosphatases | 0 | Direct |
49452,52799
49452 - Starch-binding domain-like
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
49899,48726
49899 - Concanavalin A-like lectins/glucanases
48726 - Immunoglobulin | 0 | Direct |
52799,52799
52799 - (Phosphotyrosine protein) phosphatases II
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
52799,56091
52799 - (Phosphotyrosine protein) phosphatases II
56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
53639,56784
53639 - AraD/HMP-PK domain-like
56784 - HAD-like | 0 | Direct |
51069,49265
51069 - Carbonic anhydrase
49265 - Fibronectin type III | 0 | Direct |
52799,49562
52799 - (Phosphotyrosine protein) phosphatases II
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
52821,52799
52821 - Rhodanese/Cell cycle control phosphatase
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
52087,52799
52087 - CRAL/TRIO domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0 | Direct |
55550,52799
55550 - SH2 domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
56300,47473
56300 - Metallo-dependent phosphatases
47473 - EF-hand | 0 | Direct |
54211,54211
54211 - Ribosomal protein S5 domain 2-like
54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
56300,56300
56300 - Metallo-dependent phosphatases
56300 - Metallo-dependent phosphatases | 0 | Direct |
56784,52540
56784 - HAD-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
54236,56784
54236 - Ubiquitin-like
56784 - HAD-like | 0 | Direct |
54236,47031
54236 - Ubiquitin-like
47031 - Second domain of FERM | 0 | Direct |
50729,52799
50729 - PH domain-like
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0 | Direct |
55154,56091
55154 - CYTH-like phosphatases
56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
56300,55816
56300 - Metallo-dependent phosphatases
55816 - 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain | 0 | Direct |
109715,52799
109715 - DEK C-terminal domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
56568,47233
56568 - Non-globular alpha+beta subunits of globular proteins
47233 - Bacterial GAP domain | 0 | Direct |
47031,50729
47031 - Second domain of FERM
50729 - PH domain-like | 3.502e-16 | Direct |
53335,52949
53335 - S-adenosyl-L-methionine-dependent methyltransferases
52949 - Macro domain-like | 0.00000000000001513 | Direct |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.0000007029 | Direct |
53756,56784
53756 - UDP-Glycosyltransferase/glycogen phosphorylase
56784 - HAD-like | 0.00003603 | Direct |
52058,52058
52058 - L domain-like
52058 - L domain-like | 0.00007151 | Direct |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0.01584 | Inherited |
56091,50249
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 1 | Inherited |
(show details)
Supra-domains annotated to this EC term (SPEO level: Moderately Informative)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
46938,52087,52799
46938 - CRAL/TRIO N-terminal domain
52087 - CRAL/TRIO domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
49265,49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III
49265 - Fibronectin type III | 0 | DIRECT |
55550,55550,52799
55550 - SH2 domain
55550 - SH2 domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
49899,48726,49265
49899 - Concanavalin A-like lectins/glucanases
48726 - Immunoglobulin
49265 - Fibronectin type III | 0 | DIRECT |
56568,47233,52799
56568 - Non-globular alpha+beta subunits of globular proteins
47233 - Bacterial GAP domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
56784,54211,54211
56784 - HAD-like
54211 - Ribosomal protein S5 domain 2-like
54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
48726,49265,49265
48726 - Immunoglobulin
49265 - Fibronectin type III
49265 - Fibronectin type III | 0 | DIRECT |
81324,52799,49562
81324 - Voltage-gated potassium channels
52799 - (Phosphotyrosine protein) phosphatases II
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
52799,56091,50249
52799 - (Phosphotyrosine protein) phosphatases II
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
54236,47031,50729
54236 - Ubiquitin-like
47031 - Second domain of FERM
50729 - PH domain-like | 0 | DIRECT |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.00000000000001102 | DIRECT |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.00000005045 | DIRECT |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
46938,52087,52799
46938 - CRAL/TRIO N-terminal domain
52087 - CRAL/TRIO domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
49265,49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III
49265 - Fibronectin type III | 0 | Direct |
55550,55550,52799
55550 - SH2 domain
55550 - SH2 domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
49899,48726,49265
49899 - Concanavalin A-like lectins/glucanases
48726 - Immunoglobulin
49265 - Fibronectin type III | 0 | Direct |
56568,47233,52799
56568 - Non-globular alpha+beta subunits of globular proteins
47233 - Bacterial GAP domain
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
56784,54211,54211
56784 - HAD-like
54211 - Ribosomal protein S5 domain 2-like
54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
48726,49265,49265
48726 - Immunoglobulin
49265 - Fibronectin type III
49265 - Fibronectin type III | 0 | Direct |
81324,52799,49562
81324 - Voltage-gated potassium channels
52799 - (Phosphotyrosine protein) phosphatases II
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
52799,56091,50249
52799 - (Phosphotyrosine protein) phosphatases II
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | Direct |
54236,47031,50729
54236 - Ubiquitin-like
47031 - Second domain of FERM
50729 - PH domain-like | 0 | Direct |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.00000000000001102 | Direct |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.00000005045 | Direct |
Plot distribution on phylogenetic tree for Individual Supra-domains annotated by this EC term
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A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
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heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
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