CTD Chemicals (CC): Amines 

Root: CC Hierarchy (CTD chemicals from Comparative Toxicogenomics Database)

Shortest distance to current term (+ for parents, - for children)	CC term [CC ID] <#Children>	#Domains (Superfamily|Family)	#Supra-domain (Single|Duplex|Triple)
+ + 2:	Chemicals [MESH:D] <13>
+ 1:	Organic Chemicals [MESH:D009930] <621>	(617|829)	(620|532|254)
0:	Amines [MESH:D000588] <138>	(228|283)	(235|204|110)
- 1:	Aniline Compounds [MESH:D000814] <747>	(100|121)	(107|65|35)
- 1:	Quaternary Ammonium Compounds [MESH:D000644] <622>	(22|23)	(23|4|0)
- 1:	Aminopyridines [MESH:D000631] <280>	(18|16)	(21|10|6)
- 1:	Propylamines [MESH:D011437] <192>	(7|5)	(7|1|0)
- 1:	Polyamines [MESH:D011073] <174>	(46|49)	(47|21|7)
- 1:	Benzylamines [MESH:D001596] <171>	(3|3)	(4|0|0)
- 1:	Ethylamines [MESH:D005021] <170>	(25|26)	(26|10|5)
- 1:	Cyclohexylamines [MESH:D003514] <118>	(1|1)	(1|0|0)
- 1:	Methylamines [MESH:D008744] <112>	(2|1)	(2|0|0)
- 1:	Hydroxylamines [MESH:D006898] <82>	(42|52)	(44|41|25)
- 1:	2-Naphthylamine [MESH:D015081] <77>	(2|3)	(2|1|0)
- 1:	Butylamines [MESH:D002082] <62>	(0|0)	(0|0|0)
- 1:	1-Naphthylamine [MESH:D015057] <50>	(8|9)	(8|3|0)
- 1:	Amino Alcohols [MESH:D000605] <48>	(31|37)	(33|12|4)
- 1:	Catecholamines [MESH:D002395] <25>	(22|22)	(22|9|4)
- 1:	Allylamine [MESH:D000499] <20>	(0|0)	(0|0|0)
- 1:	Chloramines [MESH:D002700] <12>	(0|0)	(0|0|0)
- 1:	Mannich Bases [MESH:D008352] <7>	(0|0)	(0|0|0)
- 1:	Biogenic Amines [MESH:D001679] <4>	(22|27)	(24|9|3)
- 1:	(1H-pyridin-4-ylidene)amine [MESH:C542865]	(0|0)	(0|0|0)
- 1:	(2'-(4-aminophenyl)-(2,5'-bi-1H-benzimidazol)-5-amine) [MESH:C579147]	(0|0)	(0|0|0)
- 1:	(2-isobutoxyphenyl)amine [MESH:C000604854]	(0|0)	(0|0|0)
- 1:	(bis(1-methyl-imidazol-2-yl)methyl)(1-methyl-4-nitroimidazol-2-yl)methyl amine [MESH:C517715]	(0|0)	(0|0|0)
- 1:	1,2-hexadecanediamine [MESH:C119632]	(0|0)	(0|0|0)
- 1:	1,3-dimethylamylamine [MESH:C571979]	(0|0)	(0|0|0)
- 1:	1,3-dimethylbutylamine [MESH:C000601638]	(0|0)	(0|0|0)
- 1:	1,3-heptadecanediamine [MESH:C119631]	(0|0)	(0|0|0)
- 1:	1,4-dimethylamylamine [MESH:C000632575]	(0|0)	(0|0|0)
- 1:	1-(4-nitrophenyl)-1H-tetrazol-5-amine [MESH:C533716]	(0|0)	(0|0|0)
- 1:	1-(tert-butylaminocarbonyl)-2,2-dimethylaminoethane [MESH:C471927]	(0|0)	(0|0|0)
- 1:	1-amino-6-(3,5-dimethyl-1-adamantylamine)hexane [MESH:C000595248]	(0|0)	(0|0|0)
- 1:	1-bicyclo(1.1.1)pentylamine [MESH:C568027]	(0|0)	(0|0|0)
- 1:	1-cyclobutyl-7-(dimethylamino)-1-hydroxy-1-phenyl-5-heptyn-2-one [MESH:C071274]	(0|0)	(0|0|0)
- 1:	1-nonylamine [MESH:C036253]	(0|0)	(0|0|0)
- 1:	1-phenylcyclopentylamine [MESH:C072530]	(0|0)	(0|0|0)
- 1:	10-amine-4-azadecylsilica [MESH:C520115]	(0|0)	(0|0|0)
- 1:	2,2'-dipicolylamine [MESH:C501847]	(0|0)	(0|0|0)
- 1:	2,3-diaminopropyl sulfate [MESH:C406383]	(0|0)	(0|0|0)
- 1:	2-(2,4-dichlorobenzyl)-2,3-dihydro-1H-inden-1-amine [MESH:C548617]	(0|0)	(0|0|0)
- 1:	2-(2-(2-ethoxybenzoylamino)-4-chlorophenoxy)-N-(2-ethoxybenzoyl)benzamine [MESH:C521359]	(0|0)	(0|0|0)
- 1:	2-amino-2,3,3a,4,5,6-hexahydro-1H-phenalene [MESH:C430450]	(0|0)	(0|0|0)
- 1:	2-amino-3-(3'-aminopropoxy)benzoic acid [MESH:C000621552]	(0|0)	(0|0|0)
- 1:	2-amino-6-methylheptane [MESH:C000632592]	(0|0)	(0|0|0)
- 1:	2-aminotridecane [MESH:C004177]	(0|0)	(0|0|0)
- 1:	2-propyl-1-aminopentane [MESH:C068587]	(0|0)	(0|0|0)
- 1:	3-(4'-(8'-aminoethyl)phenoxy)bulbispermine [MESH:C433847]	(0|0)	(0|0|0)
- 1:	3-aminotridecan-4-one [MESH:C545726]	(0|0)	(0|0|0)
- 1:	4,4-diphenyl-2-cyclopentenylamine [MESH:C092685]	(0|0)	(0|0|0)
- 1:	5-(biotinamido)pentylamine [MESH:C076022]	(0|0)	(0|0|0)
- 1:	5-aminopentyl-2,3,4,2',3',4',6'-hepta-O-acetylgentiobioside [MESH:C069572]	(0|0)	(0|0|0)
- 1:	7-amine-4-azaheptylsilica [MESH:C520114]	(0|0)	(0|0|0)
- 1:	7-amino-7,8-dihydro-alpha-bisabolene [MESH:C498356]	(0|0)	(0|0|0)
- 1:	7-tetradecenylamine [MESH:C102981]	(0|0)	(0|0|0)
- 1:	9-tetradecenylamine [MESH:C102980]	(0|0)	(0|0|0)
- 1:	AA9 compound [MESH:C000612900]	(0|0)	(0|0|0)
- 1:	AG525E1 [MESH:C529699]	(0|0)	(0|0|0)
- 1:	Amberlite LA-2 [MESH:C016214]	(0|0)	(0|0|0)
- 1:	BAY-84-7296 [MESH:C586268]	(0|0)	(0|0|0)
- 1:	BMS 181866-02 [MESH:C103126]	(0|0)	(0|0|0)
- 1:	Gabapentin [MESH:D000077206]	(0|0)	(0|0|0)
- 1:	Korsolex AF [MESH:C498336]	(0|0)	(0|0|0)
- 1:	L-kedarosamine [MESH:C520456]	(0|0)	(0|0|0)
- 1:	LCL521 [MESH:C000632186]	(0|0)	(0|0|0)
- 1:	LY 393613 [MESH:C419623]	(0|0)	(0|0|0)
- 1:	Meridol [MESH:C059813]	(0|0)	(0|0|0)
- 1:	Methacrol 2138F [MESH:C070408]	(0|0)	(0|0|0)
- 1:	N'-(7-chloro-quinolin-4-yl)-N,N-dimethyl-ethane-1,2-diamine [MESH:C529177]	(0|0)	(0|0|0)
- 1:	N,N'-bis(2-((1-amino-9-oxo-9,10-dihydroacridine-4-carbonyl)amino)ethyl)-N,N'-dimethylpropylenediamin [MESH:C464528]	(0|0)	(0|0|0)
- 1:	N,N-bis(2-picolyl)amine [MESH:C506131]	(0|0)	(0|0|0)
- 1:	N,N-bis(3-aminopropyl)dodecylamine [MESH:C433886]	(0|0)	(0|0|0)
- 1:	N,N-bis(4,5-dimethyl-2-hydroxybenzyl)-N-(2-pyridylmethyl)amine [MESH:C545912]	(0|0)	(0|0|0)
- 1:	N,N-bis(carbazolylmethyl)amine [MESH:C550902]	(0|0)	(0|0|0)
- 1:	N,N-dimethyl-1-dodecanamine [MESH:C036252]	(0|0)	(0|0|0)
- 1:	N,N-dimethyl-N-(3-dodecylcarbonyloxypropyl)amine-N-oxide [MESH:C411244]	(0|0)	(0|0|0)
- 1:	N-(2-ethoxyethanol)-bis(2-picolyl)amine [MESH:C502238]	(0|0)	(0|0|0)
- 1:	N-benzyl-N-methyl-dodecan-1-amine [MESH:C000629856]	(0|0)	(0|0|0)
- 1:	N-benzylated triamine [MESH:C438205]	(0|0)	(0|0|0)
- 1:	N-bromoacetyl-n-decylamine [MESH:C025979]	(0|0)	(0|0|0)
- 1:	N-bromoacetyl-n-tetradecylamine [MESH:C025980]	(0|0)	(0|0|0)
- 1:	N-cyclohexylmethyl-N-(5-phenylpentyl)amine [MESH:C083393]	(0|0)	(0|0|0)
- 1:	N-halamine [MESH:C000629066]	(0|0)	(0|0|0)
- 1:	N-isopropylbenzylamine [MESH:C435163]	(0|0)	(0|0|0)
- 1:	N-tetradecylamine [MESH:C020514]	(0|0)	(0|0|0)
- 1:	N1-benzyl-4-methylbenzene-1,2-diamine [MESH:C497734]	(0|0)	(0|0|0)
- 1:	O-aminodihydroartemisinin [MESH:C487673]	(0|0)	(0|0|0)
- 1:	OIC-A006 [MESH:C571980]	(0|0)	(0|0|0)
- 1:	POE-15 [MESH:C585980]	(0|0)	(0|0|0)
- 1:	PR5-LL-CM01 [MESH:C000627006]	(0|0)	(0|0|0)
- 1:	Red DND-99 [MESH:C493330]	(0|0)	(0|0|0)
- 1:	SEP 225289 [MESH:C560745]	(0|0)	(0|0|0)
- 1:	U 64846 [MESH:C040927]	(0|0)	(0|0|0)
- 1:	U 83757 [MESH:C086277]	(0|0)	(0|0|0)
- 1:	abeprazan [MESH:C000634065]	(0|0)	(0|0|0)
- 1:	aldocyanoin [MESH:C021957]	(0|0)	(0|0|0)
- 1:	amine fluoride gel [MESH:C075174]	(0|0)	(0|0|0)
- 1:	ammonium di-mu-sulfatobis(trisulfatocerate(IV)) tetrahydrate [MESH:C118044]	(0|0)	(0|0|0)
- 1:	benzo (7)annulen-7-amine [MESH:C000628676]	(0|0)	(0|0|0)
- 1:	bis(2-(3-(aminopropyl)amino)ethyl)disulfide [MESH:C467793]	(0|0)	(0|0|0)
- 1:	bis(2-aminohexyl)disulfide [MESH:C075124]	(0|0)	(0|0|0)
- 1:	bis(amidoethyl-carbamoylethyl)octadecylamine [MESH:C527962]	(0|0)	(0|0|0)
- 1:	bis-hydroxyethyl-tallow amine [MESH:C055708]	(0|0)	(0|0|0)
- 1:	bromochloramine [MESH:C000602169]	(0|0)	(0|0|0)
- 1:	carpatamide A [MESH:C000591940]	(0|0)	(0|0|0)
- 1:	carpatamide B [MESH:C000591941]	(0|0)	(0|0|0)
- 1:	carpatamide C [MESH:C000591942]	(0|0)	(0|0|0)
- 1:	credneramide B [MESH:C570752]	(0|0)	(0|0|0)
- 1:	cyclooctylamine [MESH:C000540]	(0|0)	(0|0|0)
- 1:	decylamine [MESH:C004744]	(0|0)	(0|0|0)
- 1:	di(2-hydroxyethyl)hexadecylamine [MESH:C095408]	(0|0)	(0|0|0)
- 1:	dioctadecylamine [MESH:C095819]	(0|0)	(0|0|0)
- 1:	dodecylamine [MESH:C003935]	(0|0)	(0|0|0)
- 1:	glabrin [MESH:C044849]	(0|0)	(0|0|0)
- 1:	hexadecylamine [MESH:C013553]	(0|0)	(0|0|0)
- 1:	hexylamine [MESH:C007940]	(0|0)	(0|0|0)
- 1:	isoamylamine [MESH:C025371]	(0|0)	(0|0|0)
- 1:	medelamine A [MESH:C096607]	(0|0)	(0|0|0)
- 1:	medelamine B [MESH:C096608]	(0|0)	(0|0|0)
- 1:	methylenedinitramine [MESH:C508216]	(0|0)	(0|0|0)
- 1:	methylhexaneamine [MESH:C571835]	(0|0)	(0|0|0)
- 1:	n-amylamine [MESH:C005264]	(0|0)	(0|0|0)
- 1:	nitrilotriacetic acid dioctadecylamine [MESH:C095818]	(0|0)	(0|0|0)
- 1:	nitrilotriacetic acid ditetradecylamine [MESH:C405382]	(0|0)	(0|0|0)
- 1:	octylamine [MESH:C008699]	(0|0)	(0|0|0)
- 1:	octylaminolester [MESH:C025359]	(0|0)	(0|0|0)
- 1:	oleylamine [MESH:C008703]	(0|0)	(0|0|0)
- 1:	pentadecylamine [MESH:C575350]	(0|0)	(0|0|0)
- 1:	polyandrocarpamine A [MESH:C588236]	(0|0)	(0|0|0)
- 1:	polyandrocarpamine B [MESH:C588235]	(0|0)	(0|0|0)
- 1:	proxamine [MESH:C078440]	(0|0)	(0|0|0)
- 1:	rhinofluimucil [MESH:C101226]	(0|0)	(0|0|0)
- 1:	stearylamine [MESH:C009317]	(0|0)	(0|0|0)
- 1:	sterylamine [MESH:C115688]	(0|0)	(0|0|0)
- 1:	tri-N-octylamine [MESH:C038229]	(0|0)	(0|0|0)
- 1:	tri-n-dodecylamine [MESH:C044321]	(0|0)	(0|0|0)
- 1:	tris((2-(6-methylpyridyl))methyl)amine [MESH:C465009]	(0|0)	(0|0|0)
- 1:	tris((N'-tert-butylureayl)-N-ethyl)amine [MESH:C471928]	(0|0)	(0|0|0)
- 1:	tris(2-(methylthioethyl))amine [MESH:C441191]	(0|0)	(0|0|0)
- 1:	tuaminoheptane [MESH:C065369]	(0|0)	(0|0|0)

Superfamily

Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
DNA-glycosylase	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
Terpenoid synthases	0	DIRECT
PRC-barrel domain	0	DIRECT
Ribosomal protein L30p/L7e	0	DIRECT
DEK C-terminal domain	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
Nuclear receptor coactivator interlocking domain	0	DIRECT
Acyl-CoA dehydrogenase C-terminal domain-like	0	DIRECT
Purine and uridine phosphorylases	0	DIRECT
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	0	DIRECT
SIS domain	0	DIRECT
Di-copper centre-containing domain	0	DIRECT
EB1 dimerisation domain-like	0	DIRECT
CCHHC domain	0	DIRECT
DUSP-like	0	DIRECT
Inosine monophosphate dehydrogenase (IMPDH)	0	DIRECT
G protein-binding domain	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
beta-lactamase/transpeptidase-like	0	DIRECT
LeuD/IlvD-like	0	DIRECT
2Fe-2S ferredoxin-like	0	DIRECT
Nucleotide-binding domain	0	DIRECT
Peptidase/esterase 'gauge' domain	0	DIRECT
Nitric oxide (NO) synthase oxygenase domain	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
Formyltransferase	0	DIRECT
Aminomethyltransferase beta-barrel domain	0	DIRECT
Cytochrome c oxidase subunit h	0	DIRECT
post-AAA+ oligomerization domain-like	0	DIRECT
Phosphoglucomutase, C-terminal domain	0	DIRECT
LCCL domain	0	DIRECT
EPT/RTPC-like	0	DIRECT
NSFL1 (p97 ATPase) cofactor p47, SEP domain	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
C-terminal domain of adenylylcyclase associated protein	0	DIRECT
PUG domain-like	0	DIRECT
Thiolase-like	0	DIRECT
Nucleoplasmin-like core domain	0	DIRECT
P-domain of calnexin/calreticulin	0	DIRECT
AhpD-like	0	DIRECT
BRK domain-like	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
ClpS-like	0	DIRECT
Nicotinate/Quinolinate PRTase C-terminal domain-like	0	DIRECT
ISP domain	0	DIRECT
Hypothetical protein c14orf129, hspc210	0	DIRECT
Carbon-nitrogen hydrolase	0	DIRECT
Rudiment single hybrid motif	0	DIRECT
Anaphylotoxins (complement system)	0	DIRECT
FAD-binding/transporter-associated domain-like	0	DIRECT
Phosphoenolpyruvate/pyruvate domain	0	DIRECT
HMA, heavy metal-associated domain	0	DIRECT
Release factor	0	DIRECT
TB module/8-cys domain	0	DIRECT
Assembly domain of cartilage oligomeric matrix protein	0	DIRECT
TSP type-3 repeat	0	DIRECT
FAD-linked oxidases, C-terminal domain	0	DIRECT
ITPase-like	0	DIRECT
Tautomerase/MIF	0	DIRECT
FMT C-terminal domain-like	0	DIRECT
Alanine racemase C-terminal domain-like	0	DIRECT
Isocitrate/Isopropylmalate dehydrogenase-like	0	DIRECT
DNA ligase/mRNA capping enzyme, catalytic domain	0	DIRECT
PLP-binding barrel	0	DIRECT
ATP-dependent DNA ligase DNA-binding domain	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
Phosphofructokinase	0	DIRECT
GTF2I-like repeat	0	DIRECT
Aconitase iron-sulfur domain	0	DIRECT
CAPPD, an extracellular domain of amyloid beta A4 protein	0	DIRECT
Eferin C-derminal domain-like	0	DIRECT
Microbial and mitochondrial ADK, insert "zinc finger" domain	0	DIRECT
Composite domain of metallo-dependent hydrolases	0	DIRECT
Integrin beta tail domain	0	DIRECT
PK beta-barrel domain-like	0	DIRECT
4Fe-4S ferredoxins	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
N-terminal domain of cbl (N-cbl)	0	DIRECT
Acyl-CoA dehydrogenase NM domain-like	0	DIRECT
A heparin-binding domain	0	DIRECT
Fibrinogen coiled-coil and central regions	0	DIRECT
Apolipoprotein A-I	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
Myosin phosphatase inhibitor 17kDa protein, CPI-17	0	DIRECT
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	DIRECT
Proton glutamate symport protein	0	DIRECT
ADC-like	0	DIRECT
Probable bacterial effector-binding domain	0	DIRECT
p53 tetramerization domain	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
IP3 receptor type 1 binding core, domain 2	0	DIRECT
Amyloid beta a4 protein copper binding domain (domain 2)	0	DIRECT
His-Me finger endonucleases	0	DIRECT
Mitochondrial cytochrome c oxidase subunit VIIa	0	DIRECT
MAST3 pre-PK domain-like	0	DIRECT
GFP-like	0	DIRECT
RGC domain-like	0	DIRECT
Methylglyoxal synthase-like	0	DIRECT
Nucleoporin domain	0	DIRECT
Hook domain	0	DIRECT
Aminoacid dehydrogenase-like, N-terminal domain	0	DIRECT
Ribosomal protein S10	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Ribosomal protein S18	0	DIRECT
3-carboxy-cis,cis-mucoante lactonizing enzyme	0	DIRECT
Seven-hairpin glycosidases	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
ACT-like	0	DIRECT
Small-conductance potassium channel	0	DIRECT
Annexin	0	DIRECT
Creatinase/prolidase N-terminal domain	0	DIRECT
Mss4-like	0	DIRECT
Hermes dimerisation domain	0	DIRECT
Homocysteine S-methyltransferase	0	DIRECT
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain	0	DIRECT
FAD-linked oxidoreductase	0	DIRECT
RILP dimerisation region	0	DIRECT
RNase III domain-like	0	DIRECT
Ribosomal protein L10-like	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
Nuclear receptor ligand-binding domain	0.0000005364	DIRECT
EGF/Laminin	0.000001169	DIRECT
Protein kinase-like (PK-like)	0.000003361	DIRECT
Glucocorticoid receptor-like (DNA-binding domain)	0.000008357	DIRECT
PH domain-like	0.00004389	DIRECT
Calponin-homology domain, CH-domain	0.00009494	DIRECT
Ubiquitin-like	0.0001785	DIRECT
FAD/NAD(P)-binding domain	0.0004023	DIRECT
TSP-1 type 1 repeat	0.0008497	DIRECT
Fibronectin type III	0.0008677	DIRECT
Mitochondrial carrier	0.001119	INHERITED FROM: Acetaminophen || closantel
GTPase activation domain, GAP	0.001546	INHERITED FROM: Diamines || Ethylenediamines
NAD(P)-binding Rossmann-fold domains	0.002824	INHERITED FROM: Acetaminophen
Frizzled cysteine-rich domain	0.003474	INHERITED FROM: Salicylanilides || Panobinostat || Niclosamide
DEATH domain	0.003997	INHERITED FROM: EKB 569 || Diamines || abexinostat || N(1),N(11)-diethylnorspermine || HhAntag691 || Miransertib || 2-anisidine || LAQ824 || Phenylenediamines
SH2 domain	0.004677	INHERITED FROM: Acetaminophen
Complement control module/SCR domain	0.009429	INHERITED FROM: Platelet Activating Factor
Integrin domains	0.009615	INHERITED FROM: Benzylamines
Spermadhesin, CUB domain	0.01059	INHERITED FROM: Panobinostat
PDZ domain-like	0.01161	INHERITED FROM: Diamines || Aminopyridines
(Phosphotyrosine protein) phosphatases II	0.01322	INHERITED FROM: salicylideneaniline || Sertraline
Carbonic anhydrase	0.01325	INHERITED FROM: oryzalin || Sulfanilamides
Growth factor receptor domain	0.0138	INHERITED FROM: 3,4-dichloroaniline || 2-acetamidoethanethiol || belinostat || Cysteamine
Cyclin-like	0.01946	INHERITED FROM: Salicylanilides || bicalutamide || A 771726 || erucylphospho-N,N,N-trimethylpropylammonium || scriptaid || Niclosamide || Fluoxetine || Deferoxamine || abemaciclib
ARM repeat	0.02828	INHERITED FROM: Benzophenoneidum
Leucine zipper domain	0.03047	INHERITED FROM: Salicylanilides || BIX 02189 || Diamines || Ethylamines || erucylphospho-N,N,N-trimethylpropylammonium || Niclosamide || Sertraline || Egtazic Acid || 1-Naphthylamine || Phenylenediamines
Arginase/deacetylase	0.03187	INHERITED FROM: Aniline Compounds || Anilides
Cysteine-rich domain	0.03462	INHERITED FROM: Ethylenediamines
Aldolase	0.05618	INHERITED FROM: Salicylanilides || Niclosamide
Integrin alpha N-terminal domain	0.0626	INHERITED FROM: Diamines || Ethylenediamines
Rhodanese/Cell cycle control phosphatase	0.07755	INHERITED FROM: Sertraline || 1-Naphthylamine
Cytochrome P450	0.07757	INHERITED FROM: KN 93 || N,N-Dimethyltryptamine || Sulfaphenazole || 1-(4-ethylphenyl-)-N-((2-methoxyphenyl)methyl) propane-2-amine || aniline || N,N-diisopropyltryptamine || bufuralol || teriflunomide || Propranolol || almotriptan || N-ethyl-1,2-diphenylethylamine || 2-Naphthylamine || N,N-diallyl-5-methoxytryptamine || 7-methyltryptamine || Bufotenin || indopan || 2-(4-chloro-2,5-dimethoxyphenyl)-N-((2-methoxyphenyl)methyl)ethanamine || GW 3965 || Propylamines || Dimethoxyphenylethylamine || 5-methyltryptamine || Oximes || Ethambutol || Biogenic Amines || dimethocaine || Ethylamines || 5-methoxy-N,N-diisopropyltryptamine || 5-bromotryptamine || 5-fluoro-alpha-methyltryptamine || 2-anisidine || 2-(4-bromo-2,5-dimethoxyphenyl)-N-((2-methoxyphenyl)methyl)ethanamine || Lidocaine || Niclosamide || lephetamine || Sertraline || Fenamates || fenproporex || 1-Naphthylamine || Benzylamines || 5-Methoxytryptamine || Flutamide || Sulfanilamides || Biogenic Monoamines || Orphenadrine || Propanolamines || Melatonin || Toluidines || Phenethylamines || Carbanilides || 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime || 5-chlorotryptamine || 2-methyl-5-isopropenylcyclohex-2-enone oxime || N-isopropyl-1,2-diphenylethylamine || Tranylcypromine || Tryptamines || 5-fluorotryptamine
Calcium ATPase, transduction domain A	0.08078	INHERITED FROM: Methapyrilene
Orange domain-like	0.0972	INHERITED FROM: Salicylanilides || Niclosamide
Heme-dependent peroxidases	0.0972	INHERITED FROM: Methylenebis(chloroaniline) || Deferoxamine || Phenethylamines || Phenylenediamines
Heat shock protein 70kD (HSP70), peptide-binding domain	0.0972	INHERITED FROM: Hydroxylamines || Catecholamines || indirubin-3'-monoxime || Biogenic Amines || Isoproterenol || Biogenic Monoamines || Deferoxamine
Glycerol-3-phosphate (1)-acyltransferase	0.1111	INHERITED FROM: 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime
HD-domain/PDEase-like	0.1113	INHERITED FROM: Roflumilast || Aminopyridines
Caspase-like	0.1155	INHERITED FROM: Methamphetamine || Catecholamines || 5-((4-methylphenyl)methylene)-2-(phenylamino)-4(5H)-thiazolone || Propranolol || abexinostat || 2-amino-3-hydroxy-2-hydroxymethylpropyl 3-acetylbetulinoate || Biogenic Amines || Vorinostat || Ethylamines || NMS-873 || Niclosamide || Isoproterenol || Sertraline || N,N-dimethylphytosphingosine || Egtazic Acid || Fenamates || 1-Naphthylamine || Verapamil || Biogenic Monoamines || LAQ824 || Propanolamines || Melatonin || Deferoxamine || Phenethylamines || Tryptamines || Phenylenediamines
Bromodomain	0.1237	INHERITED FROM: OTX015
MHC antigen-recognition domain	0.1378	INHERITED FROM: Benzylammonium Compounds || Benzalkonium Compounds
Ferredoxin reductase-like, C-terminal NADP-linked domain	0.1416	INHERITED FROM: Hydroxydopamines || Biogenic Monoamines
Riboflavin synthase domain-like	0.1416	INHERITED FROM: Hydroxydopamines || Biogenic Monoamines
Bcl-2 inhibitors of programmed cell death	0.1439	INHERITED FROM: Methamphetamine || Salicylanilides || Amphetamine || Catecholamines || EKB 569 || bicalutamide || NVP-BKM120 || 4-methylthioamphetamine || Dextroamphetamine || N-Methyl-3,4-methylenedioxyamphetamine || Biogenic Amines || acetochlor || Ethylamines || Miransertib || Amphetamines || NMS-873 || Niclosamide || Isoproterenol || N,N-dimethylphytosphingosine || Egtazic Acid || Fenamates || Sphingosine || 1-Naphthylamine || Biogenic Monoamines || LAQ824 || Melatonin || Toluidines || Phenethylamines || Tryptamines
Kringle-like	0.1537	INHERITED FROM: Propranolol || Norepinephrine || 2-chloro-5-nitrobenzanilide || Isoproterenol || Sphingosine || Propanolamines || Phenethylamines
Acetyl-CoA synthetase-like	0.156	INHERITED FROM: 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime
SMAD MH1 domain	0.1649	INHERITED FROM: trichostatin A
Interleukin 8-like chemokines	0.1657	INHERITED FROM: Pentetic Acid || roflumilast N-oxide || Albuterol || Catecholamines || N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine || Roflumilast || Benzylammonium Compounds || Benzethonium || Benzalkonium Compounds || butenafine || Oximes || Ethylamines || 4-aminobenzhydrazide || 2-anisidine || Isoproterenol || 7-bromoindirubin-3'-oxime || Benzylamines || Sulfanilamides || Sulfapyridine || Phenethylamines || methylbenzethonium chloride || Gadolinium DTPA || Phenylenediamines
Nucleotide cyclase	0.1708	INHERITED FROM: Methapyrilene || Ethylenediamines || Aminopyridines
Sema domain	0.1774	INHERITED FROM: belinostat
GST C-terminal domain-like	0.1859	INHERITED FROM: Dihydroxyphenylalanine || Cysteinyldopa || Fenamates
Periplasmic binding protein-like II	0.1874	INHERITED FROM: Propylamines || Citalopram
Ras GEF	0.2044	INHERITED FROM: Methapyrilene
Ferritin-like	0.2121	INHERITED FROM: Phenylenediamines
Metallothionein	0.2178	INHERITED FROM: Salicylanilides || N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine || Diamines || Ethylenediamines || Niclosamide || Polyamines || Phenylenediamines
Leukotriene A4 hydrolase N-terminal domain	0.2178	INHERITED FROM: 2-Naphthylamine
UDP-Glycosyltransferase/glycogen phosphorylase	0.2363	INHERITED FROM: Furosemide || triclocarban || Fenamates || Sulfanilamides || Carbanilides
PYP-like sensor domain (PAS domain)	0.2371	INHERITED FROM: 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine || Catecholamines || Ethylamines
TIMP-like	0.265	INHERITED FROM: Catecholamines || Isoproterenol
ABC transporter transmembrane region	0.3046	INHERITED FROM: Catecholamines || Metaproterenol || 4'-methoxy-1-naphthylfenoterol || Oximes || Ethylamines || Sulfanilamides || Verapamil || Propanolamines || Phenethylamines || 6-bromoindirubin-3'-oxime
dsRNA-binding domain-like	0.3046	INHERITED FROM: beta-methylcholine
C2 domain (Calcium/lipid-binding domain, CaLB)	0.3199	INHERITED FROM: Diamines || Ethylenediamines || Polyamines
MIR domain	0.3226	INHERITED FROM: Vorinostat
TNF receptor-like	0.3655	INHERITED FROM: HhAntag691 || 2-anisidine
Regulator of G-protein signaling, RGS	0.3806	INHERITED FROM: Propanolamines
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0.3917	INHERITED FROM: Dopamine || Egtazic Acid
A DNA-binding domain in eukaryotic transcription factors	0.3964	INHERITED FROM: Amphetamine || Ethylamines || Sertraline || 1-Naphthylamine || Phenethylamines || Phenylenediamines
ClpP/crotonase	0.4125	INHERITED FROM: 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime
Voltage-gated potassium channels	0.4277	INHERITED FROM: Tetraethylammonium Compounds || Niflumic Acid || ezogabine || Lidocaine || Mexiletine || Verapamil || Flufenamic Acid || Propanolamines
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0.4385	INHERITED FROM: EGFR tyrosine kinase inhibitor 324674
Inhibitor of apoptosis (IAP) repeat	0.4598	INHERITED FROM: EKB 569 || NVP-BKM120 || Crizotinib
MFS general substrate transporter	0.4598	INHERITED FROM: Phenacetin || Furosemide || Propranolol || Serotonin || Tetraethylammonium Compounds || Diphenhydramine || 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide || Norepinephrine || Ethylamines || Etilefrine || Lidocaine || Fenamates || Propanolamines || talinolol || Methylamines
Thioredoxin-like	0.474	INHERITED FROM: Dihydroxyphenylalanine || Cysteinyldopa || trioctylmethylammonium || didecyldimethylammonium || Fenamates || fluazinam
Ribosomal protein S5 domain 2-like	0.4787	INHERITED FROM: Egtazic Acid
Toll/Interleukin receptor TIR domain	0.5109	INHERITED FROM: 2-anisidine || 7-bromoindirubin-3'-oxime
Cation efflux protein transmembrane domain-like	0.5266	INHERITED FROM: N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine
Thioesterase/thiol ester dehydrase-isomerase	0.5995	INHERITED FROM: Oximes || 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime
Flavoproteins	0.5995	INHERITED FROM: Biogenic Amines || Fenamates || Biogenic Monoamines
Periplasmic binding protein-like I	0.6045	INHERITED FROM: Propylamines || Citalopram
DBL homology domain (DH-domain)	0.6066	INHERITED FROM: Diamines || Ethylenediamines || Aminopyridines || Polyamines
Hemopexin-like domain	0.6578	INHERITED FROM: 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine || Mercaptoethylamines || CGS 27023A || 4-(4-(4-fluorophenoxy)benzenesulfonylamino)tetrahydropyran-4-carboxylic acid hydroxyamide || Ethylamines || Egtazic Acid || Cysteamine
Retrovirus zinc finger-like domains	0.6578	INHERITED FROM: beta-methylcholine
p53-like transcription factors	0.6755	INHERITED FROM: Salicylanilides || N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine || Edetic Acid || A 771726 || Spermidine || Putrescine || N(1),N(11)-diethylnorspermine || Spermine || Biogenic Amines || Norepinephrine || 2-anisidine || Niclosamide || 1-Naphthylamine || Biogenic Monoamines
Concanavalin A-like lectins/glucanases	0.6781	INHERITED FROM: Panobinostat
PGBD-like	0.6892	INHERITED FROM: 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine || Mercaptoethylamines || CGS 27023A || 4-(4-(4-fluorophenoxy)benzenesulfonylamino)tetrahydropyran-4-carboxylic acid hydroxyamide || Ethylamines || Egtazic Acid || Cysteamine || Propanolamines
Lipocalins	0.6936	INHERITED FROM: 1-anilino-8-naphthalenesulfonate || Anilino Naphthalenesulfonates
Metalloproteases ("zincins"), catalytic domain	0.7102	INHERITED FROM: 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine || Mercaptoethylamines || CGS 27023A || PD 0325901 || Diamines || Metoprolol || Ethylenediamines || 4-(4-(4-fluorophenoxy)benzenesulfonylamino)tetrahydropyran-4-carboxylic acid hydroxyamide || Diphenylamine || Cysteamine || Polyamines
alpha/beta-Hydrolases	0.7123	INHERITED FROM: Oximes
Neurotransmitter-gated ion-channel transmembrane pore	0.7241	INHERITED FROM: Acetylcholine || N-Methyl-3,4-methylenedioxyamphetamine || Biogenic Amines || Tubocurarine || Amphetamines || N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline || Phenethylamines || Carbachol
Nicotinic receptor ligand binding domain-like	0.7241	INHERITED FROM: Acetylcholine || N-Methyl-3,4-methylenedioxyamphetamine || Biogenic Amines || Tubocurarine || Amphetamines || N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline || Phenethylamines || Carbachol
E set domains	0.7639	INHERITED FROM: 2-anisidine
NAD(P)-linked oxidoreductase	0.7955	INHERITED FROM: Meclofenamic Acid || 3,4-dichloroaniline || Diamines || cresidine || Fenamates || Flufenamic Acid || Polyamines || Phenylenediamines
TNF-like	0.8136	INHERITED FROM: peroben || Diphenhydramine
EF-hand	0.8231	INHERITED FROM: Diamines || Aminopyridines || Polyamines
Nucleic acid-binding proteins	0.8312	INHERITED FROM: Quaternary Ammonium Compounds
Actin-like ATPase domain	0.8376	INHERITED FROM: Catecholamines || indirubin-3'-monoxime || Biogenic Amines || Biogenic Monoamines
L domain-like	0.849	INHERITED FROM: Mercaptoethylamines || 2-acetamidoethanethiol || Cysteamine
SNF-like	0.8505	INHERITED FROM: Methamphetamine || phenethylamine || tryptamine || 5-(2-aminopropyl)benzofuran || Serotonin || 4-methoxymethamphetamine || Octopamine || Dextroamphetamine || Dimethoxyphenylethylamine || Norepinephrine || Amphetamines || 4-fluoroamphetamine || 2-(4-bromo-2,5-dimethoxyphenyl)-N-((2-methoxyphenyl)methyl)ethanamine || Fluoxetine || Dopamine || Cyclohexylamines || indatraline || 2-(4-bromo-2,5-dimethoxyphenyl)ethylamine || 2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone || Tyramine || Phenethylamines || Methylamines || Tryptamines
FabD/lysophospholipase-like	0.8931	INHERITED FROM: Oximes || 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime
Homeodomain-like	0.9704	INHERITED FROM: Panobinostat || belinostat || Chir 98014
TRAF domain-like	0.9758	INHERITED FROM: 2-anisidine
4-helical cytokines	0.9771	INHERITED FROM: Pentetic Acid || Albuterol || Catecholamines || Benzylammonium Compounds || Oximes || Biogenic Amines || Histamine || Ethylamines || 2-anisidine || 4-nitrososulfamethoxazole || Egtazic Acid || 7-bromoindirubin-3'-oxime || Sulfanilamides || Biogenic Monoamines || Propanolamines || Gadolinium DTPA || 4-methylhistamine
Histone-fold	1	INHERITED FROM: N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine || OTX015
C-type lectin-like	1	INHERITED FROM: Nebivolol || Platelet Activating Factor
Family A G protein-coupled receptor-like	1	INHERITED FROM: 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate || 1-(8-bromobenzo(1,2-b;4,5-b')difuran-4-yl)-2-aminopropane || N-methylhistamine || Norfenfluramine || furtrethonium || BRL 37344 || 5-methylfurtrethonium || Phenylammonium Compounds || Synephrine || (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride || Octopamine || cyanopindolol || Biogenic Amines || Norepinephrine || Muscarine || 1-(2-(3-methoxyphenyl)ethyl)phenoxy-3-(dimethylamino)-2-propanol || Gallamine Triethiodide || Bethanechol Compounds || methoctramine || Epinephrine || Tyramine
Cytokine	1	INHERITED FROM: Benzylammonium Compounds || Benzalkonium Compounds || Isoproterenol
Immunoglobulin	1	INHERITED FROM: Benzylammonium Compounds || Benzalkonium Compounds

Family

Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Protein-L-isoaspartyl O-methyltransferase	0	DIRECT
Netrin-like domain (NTR/C345C module)	0	DIRECT
Nuclear receptor coactivator interlocking domain	0	DIRECT
Diap1 N-terninal region-like	0	DIRECT
Microbial and mitochondrial ADK, insert "zinc finger" domain	0	DIRECT
C5 cytosine-specific DNA methylase, DCM	0	DIRECT
Formate/glycerate dehydrogenases, substrate-binding domain	0	DIRECT
p53 tetramerization domain	0	DIRECT
Release factor	0	DIRECT
TRASH domain	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
Proton glutamate symport protein	0	DIRECT
A20-like zinc finger	0	DIRECT
Deoxycytidylate deaminase-like	0	DIRECT
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains	0	DIRECT
IP3 receptor type 1 binding core, domain 2	0	DIRECT
Hook domain	0	DIRECT
2'-5'-oligoadenylate synthetase 1, OAS1, second domain	0	DIRECT
Serine carboxypeptidase-like	0	DIRECT
Heat shock protein 90, HSP90, N-terminal domain	0	DIRECT
2Fe-2S ferredoxin domains from multidomain proteins	0	DIRECT
Annexin	0	DIRECT
Phenylalanine metabolism regulatory domain	0	DIRECT
Bacterial PLC	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
Inosine monophosphate dehydrogenase (IMPDH)	0	DIRECT
Assembly domain of cartilage oligomeric matrix protein	0	DIRECT
Hydantoinase (dihydropyrimidinase)	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
DNA ligase	0	DIRECT
Phosphoglucomutase, C-terminal domain	0	DIRECT
Ribonuclease H	0	DIRECT
BC C-terminal domain-like	0	DIRECT
DIX domain	0	DIRECT
DEATH effector domain, DED	0	DIRECT
D-aminoacid oxidase-like	0	DIRECT
Ribosomal protein S10	0	DIRECT
Hermes transposase-like	0	DIRECT
Lesion bypass DNA polymerase (Y-family), catalytic domain	0	DIRECT
Phosphofructokinase	0	DIRECT
MAST3 pre-PK domain-like	0	DIRECT
Arginase-like amidino hydrolases	0	DIRECT
PAS domain of steroid receptor coactivator 1A, NCo-A1	0	DIRECT
Oligoxyloglucan reducing end-specific cellobiohydrolase	0	DIRECT
Extracellular domain of cell surface receptors	0	DIRECT
Noncollagenous (NC1) domain of collagen IV	0	DIRECT
Mitochondrial cytochrome c oxidase subunit VIIa	0	DIRECT
P-domain of calnexin/calreticulin	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
2'-5'-oligoadenylate synthetase 1, OAS1, N-terminal domain	0	DIRECT
GTF2I-like repeat	0	DIRECT
DNA polymerase III clamp loader subunits, C-terminal domain	0	DIRECT
Dimeric isocitrate & isopropylmalate dehydrogenases	0	DIRECT
Enabled/VASP homology 1 domain (EVH1 domain)	0	DIRECT
acyl-CoA oxidase C-terminal domains	0	DIRECT
DEK C-terminal domain	0	DIRECT
MIF-related	0	DIRECT
Platelet-derived growth factor-like	0	DIRECT
Threonyl-tRNA synthetase (ThrRS), second 'additional' domain	0	DIRECT
Fibrinogen coiled-coil and central regions	0	DIRECT
PUG domain	0	DIRECT
Tetrahydrofolate dehydrogenase/cyclohydrolase	0	DIRECT
Amyloid beta a4 protein copper binding domain (domain 2)	0	DIRECT
Anaphylotoxins (complement system)	0	DIRECT
Hydantoinase (dihydropyrimidinase), catalytic domain	0	DIRECT
SelR domain	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
HMGL-like	0	DIRECT
EB1 dimerisation domain-like	0	DIRECT
ATP-dependent DNA ligase catalytic domain	0	DIRECT
Small-conductance potassium channel	0	DIRECT
CCHHC domain	0	DIRECT
DUSP, domain in ubiquitin-specific proteases	0	DIRECT
HMA, heavy metal-associated domain	0	DIRECT
Integrin beta tail domain	0	DIRECT
Leukotriene A4 hydrolase C-terminal domain	0	DIRECT
RNA editing terminal uridyl transferase 2, RET2, domain 2	0	DIRECT
BC ATP-binding domain-like	0	DIRECT
p53 DNA-binding domain-like	0	DIRECT
Synapsin domain	0	DIRECT
Apolipoprotein A-I	0	DIRECT
Myosin phosphatase inhibitor 17kDa protein, CPI-17	0	DIRECT
RILP dimerisation region	0	DIRECT
Transferrin	0	DIRECT
IMD domain	0	DIRECT
CAT-like	0	DIRECT
La domain	0	DIRECT
DNA/RNA non-specific endonuclease	0	DIRECT
P4 origin-binding domain-like	0	DIRECT
HIT (HINT, histidine triad) family of protein kinase-interacting proteins	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
BRK domain-like	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
Eukaryotic ODC-like	0	DIRECT
RIKEN cDNA 2310057j16 protein (KIAA1543)	0	DIRECT
B56-like	0	DIRECT
Homocysteine S-methyltransferase	0	DIRECT
Cystathionine synthase-like	0	DIRECT
PUA domain	0	DIRECT
LCCL domain	0	DIRECT
Cytochrome c oxidase subunit h	0	DIRECT
Retinoblastoma tumor suppressor domains	0	DIRECT
Serum paraoxonase/arylesterase 1, PON1	0	DIRECT
GDI-like N domain	0	DIRECT
Biotin dependent carboxylase carboxyltransferase domain	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Class I alpha-1;2-mannosidase, catalytic domain	0	DIRECT
NSFL1 (p97 ATPase) cofactor p47, SEP domain	0	DIRECT
Alanine racemase-like, N-terminal domain	0	DIRECT
Nitric oxide (NO) synthase oxygenase domain	0	DIRECT
Synapsin C-terminal domain	0	DIRECT
Isoprenyl diphosphate synthases	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
1,3-glucuronyltransferase	0	DIRECT
RPR domain (SMART 00582 )	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase Pyr module	0	DIRECT
Calnexin/calreticulin	0	DIRECT
Aminoacid dehydrogenase-like, C-terminal domain	0	DIRECT
N-terminal domain of cbl (N-cbl)	0	DIRECT
Reductases	0	DIRECT
Cdc48 N-terminal domain-like	0	DIRECT
Variant SAM domain	0	DIRECT
Hsp90 middle domain	0	DIRECT
TB module/8-cys domain	0	DIRECT
acyl-CoA oxidase N-terminal domains	0	DIRECT
Nucleoplasmin-like core domain	0	DIRECT
Purine and uridine phosphorylases	0	DIRECT
Steroid-binding domain	0	DIRECT
LeuD-like	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
Thiolase-related	0	DIRECT
Arfaptin, Rac-binding fragment	0	DIRECT
Domain G2 of nidogen-1	0	DIRECT
Aconitase iron-sulfur domain	0	DIRECT
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain	0	DIRECT
Ferredoxin domains from multidomain proteins	0	DIRECT
TSP type-3 repeat	0	DIRECT
Formin homology 2 domain (FH2 domain)	0	DIRECT
Tissue inhibitor of metalloproteinases, TIMP	0	DIRECT
Integrin beta EGF-like domains	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
BC N-terminal domain-like	0	DIRECT
SH3BGR (SH3-binding, glutamic acid-rich protein-like)	0	DIRECT
Ribosomal protein S18	0	DIRECT
Malic enzyme N-domain	0	DIRECT
Exostosin	0	DIRECT
A heparin-binding domain	0	DIRECT
Variant RING domain	0	DIRECT
HD domain	0	DIRECT
Eferin C-derminal domain-like	0	DIRECT
DNA ligase/mRNA capping enzyme postcatalytic domain	0	DIRECT
CAPPD, an extracellular domain of amyloid beta A4 protein	0	DIRECT
Class II glutamine amidotransferases	0	DIRECT
Glyoxalase II (hydroxyacylglutathione hydrolase)	0	DIRECT
UDP-glucose pyrophosphorylase	0	DIRECT
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain	0	DIRECT
MBT repeat	0	DIRECT
C-terminal domain of adenylylcyclase associated protein	0	DIRECT
RGC domain	0	DIRECT
Formyltransferase	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
HCDH C-domain-like	0	DIRECT
Cell cycle control phosphatase, catalytic domain	0	DIRECT
Cullin repeat	0	DIRECT
Carbamilase	0	DIRECT
SCF ubiquitin ligase complex WHB domain	0	DIRECT
Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain	0	DIRECT
Aminomethyltransferase beta-barrel domain	0	DIRECT
Thrombospondin C-terminal domain	0	DIRECT
Nuclear receptor ligand-binding domain	0.0000004535	DIRECT
Nuclear receptor	0.0000008962	DIRECT
Protein kinases, catalytic subunit	0.00001635	DIRECT
Calponin-homology domain, CH-domain	0.00008868	DIRECT
DEATH domain, DD	0.0003676	DIRECT
TSP-1 type 1 repeat	0.0007974	DIRECT
Fibronectin type III	0.0009517	DIRECT
Mitochondrial carrier	0.001347	INHERITED FROM: Acetaminophen || Anilides || closantel
EGF-type module	0.001519	INHERITED FROM: KB R7785 || Platelet Activating Factor || Aminopyridines || Polyamines
Frizzled cysteine-rich domain	0.003055	INHERITED FROM: Salicylanilides || Panobinostat || Niclosamide
Spermadhesin, CUB domain	0.004474	INHERITED FROM: Panobinostat
SH2 domain	0.004696	INHERITED FROM: Acetaminophen
PDZ domain	0.005873	INHERITED FROM: Diamines
Alcohol dehydrogenase-like, N-terminal domain	0.006428	INHERITED FROM: Acetaminophen
SAM (sterile alpha motif) domain	0.006549	INHERITED FROM: belinostat
Integrin domains	0.008655	INHERITED FROM: Benzylamines
Ras-binding domain, RBD	0.008814	INHERITED FROM: Niclosamide
Complement control module/SCR domain	0.008918	INHERITED FROM: Platelet Activating Factor
PAPS sulfotransferase	0.01136	INHERITED FROM: Ropivacaine || 2-Naphthylamine || Fenamates
DEP domain	0.01182	INHERITED FROM: Niclosamide
Alcohol dehydrogenase-like, C-terminal domain	0.01182	INHERITED FROM: Acetaminophen
Carbonic anhydrase	0.01182	INHERITED FROM: oryzalin || Sulfanilamides
Pleckstrin-homology domain (PH domain)	0.0224	INHERITED FROM: GSK2110183 || GSK2141795 || Diamines
Histone lysine methyltransferases	0.02509	INHERITED FROM: Deferoxamine
Leucine zipper domain	0.02911	INHERITED FROM: Salicylanilides || BIX 02189 || Diamines || Ethylamines || erucylphospho-N,N,N-trimethylpropylammonium || Niclosamide || Sertraline || Egtazic Acid || 1-Naphthylamine || Phenylenediamines
Cyclin	0.03216	INHERITED FROM: Salicylanilides || bicalutamide || A 771726 || erucylphospho-N,N,N-trimethylpropylammonium || scriptaid || Niclosamide || Fluoxetine || Quaternary Ammonium Compounds || Deferoxamine || abemaciclib
Integrin alpha N-terminal domain	0.04152	INHERITED FROM: Diamines || Ethylenediamines
Caspase recruitment domain, CARD	0.04152	INHERITED FROM: Egtazic Acid
C1 set domains (antibody constant domain-like)	0.05089	INHERITED FROM: Benzylammonium Compounds || Benzalkonium Compounds
Leukotriene A4 hydrolase catalytic domain	0.05102	INHERITED FROM: 2-Naphthylamine
PWWP domain	0.05292	INHERITED FROM: Hydroxamic Acids
Dual specificity phosphatase-like	0.05669	INHERITED FROM: Sertraline || 1-Naphthylamine
Growth factor receptor domain	0.06697	INHERITED FROM: Mercaptoethylamines || 2-acetamidoethanethiol || Cysteamine
Histone deacetylase, HDAC	0.06731	INHERITED FROM: Vorinostat
Calcium ATPase, transduction domain A	0.07607	INHERITED FROM: Methapyrilene
Cytochrome P450	0.0853	INHERITED FROM: KN 93 || N,N-Dimethyltryptamine || Sulfaphenazole || 1-(4-ethylphenyl-)-N-((2-methoxyphenyl)methyl) propane-2-amine || aniline || N,N-diisopropyltryptamine || bufuralol || teriflunomide || Propranolol || almotriptan || N-ethyl-1,2-diphenylethylamine || N,N-diallyl-5-methoxytryptamine || 7-methyltryptamine || Bufotenin || indopan || 2-(4-chloro-2,5-dimethoxyphenyl)-N-((2-methoxyphenyl)methyl)ethanamine || GW 3965 || Propylamines || Dimethoxyphenylethylamine || 5-methyltryptamine || Oximes || Ethambutol || Biogenic Amines || dimethocaine || Ethylamines || 5-methoxy-N,N-diisopropyltryptamine || 5-bromotryptamine || 5-fluoro-alpha-methyltryptamine || 2-anisidine || 2-(4-bromo-2,5-dimethoxyphenyl)-N-((2-methoxyphenyl)methyl)ethanamine || Lidocaine || Niclosamide || lephetamine || Sertraline || Fenamates || fenproporex || 1-Naphthylamine || Benzylamines || 5-Methoxytryptamine || Flutamide || Sulfanilamides || Biogenic Monoamines || Orphenadrine || Mefenamic Acid || Propanolamines || Toluidines || Phenethylamines || Carbanilides || 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime || 5-chlorotryptamine || 2-methyl-5-isopropenylcyclohex-2-enone oxime || N-isopropyl-1,2-diphenylethylamine || Tranylcypromine || Tryptamines || 5-fluorotryptamine
PDEase	0.08812	INHERITED FROM: Methamphetamine || Roflumilast || Ethylenediamines || Aminopyridines || Phenethylamines
TNF receptor-like	0.08812	INHERITED FROM: Aniline Compounds || HhAntag691 || 2-anisidine || Anilides
Hairy Orange domain	0.08848	INHERITED FROM: Salicylanilides || Niclosamide
Rel/Dorsal transcription factors, DNA-binding domain	0.08848	INHERITED FROM: Salicylanilides || Catecholamines || Norepinephrine || 2-anisidine || Niclosamide || 1-Naphthylamine || Biogenic Monoamines
Myeloperoxidase-like	0.08848	INHERITED FROM: Methylenebis(chloroaniline) || Deferoxamine || Phenethylamines || Phenylenediamines
Laminin-type module	0.108	INHERITED FROM: sphingosine 1-phosphate || Sphingosine
Heat shock protein 70kD (HSP70), peptide-binding domain	0.116	INHERITED FROM: Hydroxylamines || Catecholamines || Oximes || indirubin-3'-monoxime || Biogenic Amines || Isoproterenol || Biogenic Monoamines
C2 set domains	0.116	INHERITED FROM: Biogenic Monoamines
Leukotriene A4 hydrolase N-terminal domain	0.116	INHERITED FROM: 2-Naphthylamine
Bromodomain	0.1175	INHERITED FROM: OTX015
Higher-molecular-weight phosphotyrosine protein phosphatases	0.1303	INHERITED FROM: salicylideneaniline
MHC antigen-recognition domain	0.1303	INHERITED FROM: Benzylammonium Compounds || Benzalkonium Compounds
Ephrin receptor ligand binding domain	0.1327	INHERITED FROM: belinostat
Bcl-2 inhibitors of programmed cell death	0.1327	INHERITED FROM: Methamphetamine || Salicylanilides || Amphetamine || Catecholamines || EKB 569 || bicalutamide || NVP-BKM120 || 4-methylthioamphetamine || Dextroamphetamine || N-Methyl-3,4-methylenedioxyamphetamine || Biogenic Amines || acetochlor || Ethylamines || Miransertib || Amphetamines || NMS-873 || Niclosamide || Isoproterenol || N,N-dimethylphytosphingosine || Egtazic Acid || Fenamates || Sphingosine || 1-Naphthylamine || Biogenic Monoamines || LAQ824 || Melatonin || Toluidines || Phenethylamines || Tryptamines
Ras GEF	0.1363	INHERITED FROM: Methapyrilene || Ethylenediamines
Acetyl-CoA synthetase-like	0.1469	INHERITED FROM: 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime
ABC transporter transmembrane region	0.1482	INHERITED FROM: Catecholamines || Diamines || Metaproterenol || Ethylenediamines || 4'-methoxy-1-naphthylfenoterol || Oximes || Ethylamines || Sulfanilamides || Verapamil || Phenethylamines || 6-bromoindirubin-3'-oxime
SMAD MH1 domain	0.1509	INHERITED FROM: trichostatin A
Erythroid transcription factor GATA-1	0.1509	INHERITED FROM: Panobinostat
SMAD domain	0.1509	INHERITED FROM: trichostatin A
DNA replication initiator (cdc21/cdc54) N-terminal domain	0.1509	INHERITED FROM: erucylphospho-N,N,N-trimethylpropylammonium || Quaternary Ammonium Compounds
Interleukin 8-like chemokines	0.1578	INHERITED FROM: Pentetic Acid || roflumilast N-oxide || Albuterol || Catecholamines || Roflumilast || Benzylammonium Compounds || Benzethonium || Benzalkonium Compounds || butenafine || Oximes || Ethylamines || 4-aminobenzhydrazide || 2-anisidine || Isoproterenol || 7-bromoindirubin-3'-oxime || Benzylamines || Sulfanilamides || Sulfapyridine || Phenethylamines || methylbenzethonium chloride || Gadolinium DTPA || Phenylenediamines
Adenylyl and guanylyl cyclase catalytic domain	0.1589	INHERITED FROM: Methapyrilene || Ethylenediamines || Aminopyridines
Caspase catalytic domain	0.1646	INHERITED FROM: Methamphetamine || Catecholamines || 5-((4-methylphenyl)methylene)-2-(phenylamino)-4(5H)-thiazolone || Propranolol || abexinostat || 2-amino-3-hydroxy-2-hydroxymethylpropyl 3-acetylbetulinoate || Biogenic Amines || Vorinostat || Ethylamines || Niflumic Acid || NMS-873 || Niclosamide || Isoproterenol || Sertraline || N,N-dimethylphytosphingosine || Egtazic Acid || Fenamates || Sphingosine || 1-Naphthylamine || Verapamil || Biogenic Monoamines || LAQ824 || Propanolamines || Melatonin || Deferoxamine || Phenethylamines || Tryptamines || Phenylenediamines
Short-chain cytokines	0.1646	INHERITED FROM: Albuterol || Oximes || Biogenic Amines || Histamine || Ethylamines || 2-anisidine || Egtazic Acid || 7-bromoindirubin-3'-oxime || Biogenic Monoamines
Long-chain cytokines	0.1646	INHERITED FROM: Catecholamines || Oximes || Biogenic Amines || Ethylamines || 2-anisidine || 7-bromoindirubin-3'-oxime || Biogenic Monoamines || Propanolamines || Phenethylamines
FAD/NAD-linked reductases, N-terminal and central domains	0.1646	INHERITED FROM: Bandrowski's base || Phenylenediamines
Sema domain	0.1677	INHERITED FROM: belinostat
L domain	0.1957	INHERITED FROM: Mercaptoethylamines || 2-acetamidoethanethiol || Ethylamines || Cysteamine
Metallothionein	0.2028	INHERITED FROM: Salicylanilides || N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine || Diamines || Ethylenediamines || Niclosamide || Polyamines || Phenylenediamines
UDPGT-like	0.2431	INHERITED FROM: Furosemide || triclocarban || Fenamates || Sulfanilamides || Propanolamines || Carbanilides
NADPH-cytochrome p450 reductase FAD-binding domain-like	0.2536	INHERITED FROM: Biogenic Amines || Biogenic Monoamines
NADPH-cytochrome p450 reductase-like	0.2536	INHERITED FROM: Biogenic Amines || Biogenic Monoamines
Glutathione S-transferase (GST), C-terminal domain	0.2551	INHERITED FROM: Dihydroxyphenylalanine || Cysteinyldopa || Fenamates
Phosphate binding protein-like	0.2829	INHERITED FROM: Propylamines || Citalopram
Proteasome subunits	0.2829	INHERITED FROM: EGFR tyrosine kinase inhibitor 324674
MIR domain	0.3025	INHERITED FROM: Vorinostat
Regulator of G-protein signaling, RGS	0.3103	INHERITED FROM: Propanolamines
Cofactor-dependent phosphoglycerate mutase	0.3245	INHERITED FROM: erucylphospho-N,N,N-trimethylpropylammonium
Double-stranded RNA-binding domain (dsRBD)	0.327	INHERITED FROM: beta-methylcholine
ABC transporter ATPase domain-like	0.3643	INHERITED FROM: Catecholamines || Metaproterenol || 4'-methoxy-1-naphthylfenoterol || Ethylamines || Sulfanilamides || Verapamil || Phenethylamines || 6-bromoindirubin-3'-oxime
A DNA-binding domain in eukaryotic transcription factors	0.3766	INHERITED FROM: Amphetamine || Ethylamines || Sertraline || 1-Naphthylamine || Phenethylamines || Phenylenediamines
Inhibitor of apoptosis (IAP) repeat	0.4363	INHERITED FROM: EKB 569 || NVP-BKM120 || Crizotinib
Glutathione S-transferase (GST), N-terminal domain	0.46	INHERITED FROM: Fenamates || Mefenamic Acid
S100 proteins	0.5263	INHERITED FROM: N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine || Norepinephrine
Voltage-gated potassium channels	0.5369	INHERITED FROM: Propranolol || Tetraethylammonium Compounds || Niflumic Acid || ezogabine || Fenamates || Verapamil || Flufenamic Acid || Propanolamines
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain	0.5492	INHERITED FROM: Salicylanilides || Catecholamines || Norepinephrine || 2-anisidine || Niclosamide || 1-Naphthylamine
Cation efflux protein transmembrane domain-like	0.5752	INHERITED FROM: N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine
Retinol binding protein-like	0.5853	INHERITED FROM: 1-anilino-8-naphthalenesulfonate || Anilino Naphthalenesulfonates
Toll/Interleukin receptor TIR domain	0.5885	INHERITED FROM: 2-anisidine || 7-bromoindirubin-3'-oxime
DBL homology domain (DH-domain)	0.5963	INHERITED FROM: Diamines || Ethylenediamines || Aminopyridines || Polyamines
28-residue LRR	0.6103	INHERITED FROM: 4-phenylenediamine
Nicotinic receptor ligand binding domain-like	0.6248	INHERITED FROM: Acetylcholine || N-Methyl-3,4-methylenedioxyamphetamine || Biogenic Amines || Tubocurarine || Amphetamines || N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline || Phenethylamines || Carbachol
MATH domain	0.6343	INHERITED FROM: 2-anisidine
Fibronectin type II module	0.6343	INHERITED FROM: Salicylanilides || Catecholamines || Propranolol || Norepinephrine || Niclosamide || Isoproterenol || Biogenic Monoamines || Propanolamines || Phenoxypropanolamines
Hemopexin-like domain	0.6386	INHERITED FROM: 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine || Mercaptoethylamines || CGS 27023A || 4-(4-(4-fluorophenoxy)benzenesulfonylamino)tetrahydropyran-4-carboxylic acid hydroxyamide || Ethylamines || Egtazic Acid || Cysteamine
Retrovirus zinc finger-like domains	0.6386	INHERITED FROM: beta-methylcholine
MMP N-terminal domain	0.6685	INHERITED FROM: 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine || Mercaptoethylamines || CGS 27023A || 4-(4-(4-fluorophenoxy)benzenesulfonylamino)tetrahydropyran-4-carboxylic acid hydroxyamide || Ethylamines || Egtazic Acid || Cysteamine || Propanolamines
Hypoxia-inducible factor Hif2a, C-terminal domain	0.706	INHERITED FROM: Catecholamines || Isoproterenol || Deferoxamine
Neurotransmitter-gated ion-channel transmembrane pore	0.711	INHERITED FROM: Acetylcholine || N-Methyl-3,4-methylenedioxyamphetamine || Biogenic Amines || Tubocurarine || Amphetamines || N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline || Phenethylamines || Carbachol
ets domain	0.7222	INHERITED FROM: PD 0325901 || Diphenylamine
Actin/HSP70	0.7336	INHERITED FROM: Catecholamines || indirubin-3'-monoxime || Biogenic Amines || Biogenic Monoamines
TNF-like	0.7653	INHERITED FROM: peroben || Diphenhydramine
Ngr ectodomain-like	0.7733	INHERITED FROM: 4-aminobenzhydrazide
Aldo-keto reductases (NADP)	0.7779	INHERITED FROM: Meclofenamic Acid || 3,4-dichloroaniline || Diamines || 1,2-diamino-4-nitrobenzene || cresidine || Fenamates || Flufenamic Acid || Polyamines || Phenylenediamines
Tetramerization domain of potassium channels	0.7784	INHERITED FROM: Verapamil
Cytochrome p450 reductase N-terminal domain-like	0.8151	INHERITED FROM: Biogenic Amines || Biogenic Monoamines
Pyrin domain, PYD	0.824	INHERITED FROM: 4-phenylenediamine || Phenylenediamines
SNF-like	0.8351	INHERITED FROM: Methamphetamine || phenethylamine || tryptamine || 5-(2-aminopropyl)benzofuran || Serotonin || 4-methoxymethamphetamine || Octopamine || Dextroamphetamine || Dimethoxyphenylethylamine || Norepinephrine || Amphetamines || 4-fluoroamphetamine || 2-(4-bromo-2,5-dimethoxyphenyl)-N-((2-methoxyphenyl)methyl)ethanamine || Fluoxetine || Dopamine || Cyclohexylamines || indatraline || 2-(4-bromo-2,5-dimethoxyphenyl)ethylamine || 2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone || Tyramine || Phenethylamines || Methylamines || Tryptamines
Matrix metalloproteases, catalytic domain	0.9187	INHERITED FROM: 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine || Mercaptoethylamines || CGS 27023A || 4-(4-(4-fluorophenoxy)benzenesulfonylamino)tetrahydropyran-4-carboxylic acid hydroxyamide || Ethylamines || Egtazic Acid || Cysteamine
Cytoplasmic domain of inward rectifier potassium channel	0.9254	INHERITED FROM: Propanolamines
Interleukin-1 (IL-1)	0.9714	INHERITED FROM: Catecholamines || Benzylammonium Compounds || Benzalkonium Compounds || Biogenic Amines || Ethylamines || Isoproterenol
C-type lectin domain	1	INHERITED FROM: Platelet Activating Factor
Rhodopsin-like	1	INHERITED FROM: 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate || 1-(8-bromobenzo(1,2-b;4,5-b')difuran-4-yl)-2-aminopropane || N-methylhistamine || Norfenfluramine || furtrethonium || BRL 37344 || 5-methylfurtrethonium || Phenylammonium Compounds || Synephrine || (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride || Octopamine || cyanopindolol || Biogenic Amines || Norepinephrine || Muscarine || Ethylamines || 1-(2-(3-methoxyphenyl)ethyl)phenoxy-3-(dimethylamino)-2-propanol || Gallamine Triethiodide || Bethanechol Compounds || methoctramine || Epinephrine || Tyramine
Homeodomain	1	INHERITED FROM: Panobinostat || belinostat || Chir 98014
Nucleosome core histones	1	INHERITED FROM: N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine || OTX015

Supra-domain (Single|Duplex|Triple)

Supra-domain (Single)

Highlighted in gray are those with FDR>0.001

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
beta-lactamase/transpeptidase-like	0	DIRECT
Inosine monophosphate dehydrogenase (IMPDH)	0	DIRECT
EB1 dimerisation domain-like	0	DIRECT
Carbon-nitrogen hydrolase	0	DIRECT
Acyl-CoA dehydrogenase NM domain-like	0	DIRECT
2Fe-2S ferredoxin-like	0	DIRECT
Nucleoporin domain	0	DIRECT
Tautomerase/MIF	0	DIRECT
Mss4-like	0	DIRECT
Creatinase/prolidase N-terminal domain	0	DIRECT
p53 tetramerization domain	0	DIRECT
TB module/8-cys domain	0	DIRECT
Thiolase-like	0	DIRECT
ACT-like	0	DIRECT
Ribosomal protein S18	0	DIRECT
Hypothetical protein c14orf129, hspc210	0	DIRECT
AhpD-like	0	DIRECT
RILP dimerisation region	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
MAST3 pre-PK domain-like	0	DIRECT
Hermes dimerisation domain	0	DIRECT
Probable bacterial effector-binding domain	0	DIRECT
Homocysteine S-methyltransferase	0	DIRECT
FAD-binding/transporter-associated domain-like	0	DIRECT
Fibrinogen coiled-coil and central regions	0	DIRECT
LeuD/IlvD-like	0	DIRECT
ValRS/IleRS/LeuRS editing domain	0	DIRECT
Hook domain	0	DIRECT
DNA-glycosylase	0	DIRECT
HMA, heavy metal-associated domain	0	DIRECT
PK beta-barrel domain-like	0	DIRECT
Nicotinate/Quinolinate PRTase C-terminal domain-like	0	DIRECT
Anaphylotoxins (complement system)	0	DIRECT
DNA ligase/mRNA capping enzyme, catalytic domain	0	DIRECT
CCHHC domain	0	DIRECT
FAD-linked oxidoreductase	0	DIRECT
Microbial and mitochondrial ADK, insert "zinc finger" domain	0	DIRECT
ATP-dependent DNA ligase DNA-binding domain	0	DIRECT
PRC-barrel domain	0	DIRECT
Annexin	0	DIRECT
GFP-like	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
Nuclear receptor coactivator interlocking domain	0	DIRECT
LCCL domain	0	DIRECT
Acyl-CoA dehydrogenase C-terminal domain-like	0	DIRECT
DUSP-like	0	DIRECT
FAD-linked oxidases, C-terminal domain	0	DIRECT
GTF2I-like repeat	0	DIRECT
ADC-like	0	DIRECT
post-AAA+ oligomerization domain-like	0	DIRECT
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
Nitric oxide (NO) synthase oxygenase domain	0	DIRECT
Nucleotide-binding domain	0	DIRECT
Phosphoglucomutase, C-terminal domain	0	DIRECT
Assembly domain of cartilage oligomeric matrix protein	0	DIRECT
DEK C-terminal domain	0	DIRECT
SIS domain	0	DIRECT
Aconitase iron-sulfur domain	0	DIRECT
4Fe-4S ferredoxins	0	DIRECT
Myosin phosphatase inhibitor 17kDa protein, CPI-17	0	DIRECT
Nucleoplasmin-like core domain	0	DIRECT
EPT/RTPC-like	0	DIRECT
ClpS-like	0	DIRECT
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
G protein-binding domain	0	DIRECT
Aminomethyltransferase beta-barrel domain	0	DIRECT
PLP-binding barrel	0	DIRECT
Peptidase/esterase 'gauge' domain	0	DIRECT
Mitochondrial cytochrome c oxidase subunit VIIa	0	DIRECT
Phosphoenolpyruvate/pyruvate domain	0	DIRECT
Integrin beta tail domain	0	DIRECT
Release factor	0	DIRECT
P-domain of calnexin/calreticulin	0	DIRECT
Methylglyoxal synthase-like	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Amyloid beta a4 protein copper binding domain (domain 2)	0	DIRECT
ITPase-like	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
MOSC N-terminal domain-like	0	DIRECT
A heparin-binding domain	0	DIRECT
Apolipoprotein A-I	0	DIRECT
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	DIRECT
Rudiment single hybrid motif	0	DIRECT
Phosphofructokinase	0	DIRECT
Terpenoid synthases	0	DIRECT
Aminoacid dehydrogenase-like, N-terminal domain	0	DIRECT
Di-copper centre-containing domain	0	DIRECT
FMT C-terminal domain-like	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
TSP type-3 repeat	0	DIRECT
Formyltransferase	0	DIRECT
NSFL1 (p97 ATPase) cofactor p47, SEP domain	0	DIRECT
Purine and uridine phosphorylases	0	DIRECT
Eferin C-derminal domain-like	0	DIRECT
N-terminal domain of cbl (N-cbl)	0	DIRECT
Isocitrate/Isopropylmalate dehydrogenase-like	0	DIRECT
RGC domain-like	0	DIRECT
Cytochrome c oxidase subunit h	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
PUG domain-like	0	DIRECT
Ribosomal protein L10-like	0	DIRECT
RNase III domain-like	0	DIRECT
ISP domain	0	DIRECT
Alanine racemase C-terminal domain-like	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
Proton glutamate symport protein	0	DIRECT
Seven-hairpin glycosidases	0	DIRECT
His-Me finger endonucleases	0	DIRECT
Composite domain of metallo-dependent hydrolases	0	DIRECT
CAPPD, an extracellular domain of amyloid beta A4 protein	0	DIRECT
IP3 receptor type 1 binding core, domain 2	0	DIRECT
Ribosomal protein L30p/L7e	0	DIRECT
3-carboxy-cis,cis-mucoante lactonizing enzyme	0	DIRECT
C-terminal domain of adenylylcyclase associated protein	0	DIRECT
Small-conductance potassium channel	0	DIRECT
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
Ribosomal protein S10	0	DIRECT
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	0	DIRECT
BRK domain-like	0	DIRECT
Nuclear receptor ligand-binding domain	0.0000002428	DIRECT
EGF/Laminin	0.0000005403	DIRECT
Protein kinase-like (PK-like)	0.000001599	DIRECT
Glucocorticoid receptor-like (DNA-binding domain)	0.000004084	DIRECT
PH domain-like	0.00002274	DIRECT
Calponin-homology domain, CH-domain	0.00005079	DIRECT
Ubiquitin-like	0.00009818	DIRECT
FAD/NAD(P)-binding domain	0.0002294	DIRECT
TSP-1 type 1 repeat	0.0005029	DIRECT
Fibronectin type III	0.0005141	DIRECT
Mitochondrial carrier	0.0006718	DIRECT
GTPase activation domain, GAP	0.0009449	DIRECT
NAD(P)-binding Rossmann-fold domains	0.001777	INHERITED FROM: Acetaminophen
Frizzled cysteine-rich domain	0.002207	INHERITED FROM: Niclosamide || Salicylanilides || Panobinostat
DEATH domain	0.002562	INHERITED FROM: EKB 569 || N(1),N(11)-diethylnorspermine || HhAntag691 || LAQ824 || Phenylenediamines || 2-anisidine || Diamines || abexinostat || Miransertib
SH2 domain	0.003019	INHERITED FROM: Acetaminophen
Complement control module/SCR domain	0.006331	INHERITED FROM: Platelet Activating Factor
Integrin domains	0.006465	INHERITED FROM: Benzylamines
Spermadhesin, CUB domain	0.007162	INHERITED FROM: Panobinostat
PDZ domain-like	0.007885	INHERITED FROM: Aminopyridines || Diamines
(Phosphotyrosine protein) phosphatases II	0.009056	INHERITED FROM: salicylideneaniline || Sertraline || 1-Naphthylamine
Carbonic anhydrase	0.009075	INHERITED FROM: oryzalin || Sulfanilamides
Thyroglobulin type-1 domain	0.009075	INHERITED FROM: bicalutamide
Growth factor receptor domain	0.009473	INHERITED FROM: belinostat || Mercaptoethylamines || 2-acetamidoethanethiol || Cysteamine || 3,4-dichloroaniline
Cyclin-like	0.01365	INHERITED FROM: Deferoxamine || A 771726 || scriptaid || bicalutamide || abemaciclib || Fluoxetine || Niclosamide || erucylphospho-N,N,N-trimethylpropylammonium || Salicylanilides
GroES-like	0.01966	INHERITED FROM: Acetaminophen
ARM repeat	0.02025	INHERITED FROM: Benzophenoneidum
Leucine zipper domain	0.02192	INHERITED FROM: Ethylamines || Egtazic Acid || BIX 02189 || Phenylenediamines || Niclosamide || erucylphospho-N,N,N-trimethylpropylammonium || Sertraline || Salicylanilides || Diamines || 1-Naphthylamine
Arginase/deacetylase	0.02301	INHERITED FROM: Vorinostat || Aniline Compounds || Anilides
Cysteine-rich domain	0.0251	INHERITED FROM: Ethylenediamines || Niclosamide
Aldolase	0.04181	INHERITED FROM: Niclosamide || Salicylanilides
Integrin alpha N-terminal domain	0.04687	INHERITED FROM: Ethylenediamines || Diamines
Calcium ATPase, transmembrane domain M	0.05107	INHERITED FROM: Methapyrilene
Single hybrid motif	0.05604	INHERITED FROM: beta-methylcholine
Rhodanese/Cell cycle control phosphatase	0.05882	INHERITED FROM: Sertraline || 1-Naphthylamine
Cytochrome P450	0.05884	INHERITED FROM: N-ethyl-1,2-diphenylethylamine || dimethocaine || 5-bromotryptamine || 2-Naphthylamine || teriflunomide || N,N-Dimethyltryptamine || KN 93 || aniline || 2-(4-bromo-2,5-dimethoxyphenyl)-N-((2-methoxyphenyl)methyl)ethanamine || bufuralol || Benzylamines || Ethylamines || Flutamide || 5-Methoxytryptamine || 5-fluorotryptamine || almotriptan || Phenethylamines || Propanolamines || Ethambutol || N,N-diallyl-5-methoxytryptamine || 5-chlorotryptamine || 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime || 5-methyltryptamine || Orphenadrine || 1-(4-ethylphenyl-)-N-((2-methoxyphenyl)methyl) propane-2-amine || N,N-diisopropyltryptamine || 5-methoxy-N,N-diisopropyltryptamine || indopan || Melatonin || Bufotenin || Biogenic Monoamines || Propranolol || Propylamines || Niclosamide || Sulfanilamides || Tranylcypromine || 2-(4-chloro-2,5-dimethoxyphenyl)-N-((2-methoxyphenyl)methyl)ethanamine || Toluidines || Sertraline || lephetamine || Carbanilides || 2-anisidine || Salicylanilides || fenproporex || GW 3965 || Lidocaine || Oximes || 1-Naphthylamine || Dimethoxyphenylethylamine || Biogenic Amines || Tryptamines || Fenamates || 2-methyl-5-isopropenylcyclohex-2-enone oxime || 7-methyltryptamine || N-isopropyl-1,2-diphenylethylamine || Sulfaphenazole || 5-fluoro-alpha-methyltryptamine
Calcium ATPase, transduction domain A	0.0614	INHERITED FROM: Methapyrilene
Heme-dependent peroxidases	0.07459	INHERITED FROM: Deferoxamine || Phenethylamines || Methylenebis(chloroaniline) || Phenylenediamines
Orange domain-like	0.07459	INHERITED FROM: Niclosamide || Salicylanilides
Heat shock protein 70kD (HSP70), peptide-binding domain	0.07459	INHERITED FROM: Deferoxamine || Hydroxylamines || Biogenic Monoamines || Catecholamines || indirubin-3'-monoxime || Isoproterenol || Oximes || Biogenic Amines
PLP-dependent transferases	0.07549	INHERITED FROM: Acetaminophen
Glycerol-3-phosphate (1)-acyltransferase	0.08589	INHERITED FROM: 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime
HD-domain/PDEase-like	0.08602	INHERITED FROM: Aminopyridines || Methamphetamine || Roflumilast
Caspase-like	0.08946	INHERITED FROM: Deferoxamine || Niflumic Acid || 2-amino-3-hydroxy-2-hydroxymethylpropyl 3-acetylbetulinoate || Vorinostat || 5-((4-methylphenyl)methylene)-2-(phenylamino)-4(5H)-thiazolone || Ethylamines || Egtazic Acid || Phenethylamines || Propanolamines || NMS-873 || LAQ824 || Melatonin || N,N-dimethylphytosphingosine || Biogenic Monoamines || Propranolol || Catecholamines || Phenylenediamines || Niclosamide || Sertraline || Verapamil || Isoproterenol || N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine || Oximes || 1-Naphthylamine || Methamphetamine || Biogenic Amines || abexinostat || Tryptamines || Fenamates
Bromodomain	0.09618	INHERITED FROM: OTX015
MHC antigen-recognition domain	0.1079	INHERITED FROM: Benzylammonium Compounds || Benzalkonium Compounds
Riboflavin synthase domain-like	0.1111	INHERITED FROM: Biogenic Monoamines || Hydroxydopamines || Biogenic Amines
Ferredoxin reductase-like, C-terminal NADP-linked domain	0.1111	INHERITED FROM: Biogenic Monoamines || Hydroxydopamines || Biogenic Amines
Bcl-2 inhibitors of programmed cell death	0.113	INHERITED FROM: EKB 569 || Dextroamphetamine || Vorinostat || 4-methylthioamphetamine || NVP-BKM120 || Ethylamines || Egtazic Acid || Phenethylamines || bicalutamide || NMS-873 || LAQ824 || Amphetamines || Melatonin || N,N-dimethylphytosphingosine || Biogenic Monoamines || Catecholamines || Niclosamide || acetochlor || Toluidines || Sphingosine || Salicylanilides || Isoproterenol || Oximes || 1-Naphthylamine || Methamphetamine || Biogenic Amines || N-Methyl-3,4-methylenedioxyamphetamine || Tryptamines || Fenamates || Miransertib || Amphetamine
Kringle-like	0.1211	INHERITED FROM: 2-chloro-5-nitrobenzanilide || Norepinephrine || Ethylamines || Phenethylamines || Propanolamines || Propranolol || Sphingosine || Isoproterenol
Acetyl-CoA synthetase-like	0.123	INHERITED FROM: 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime
SMAD MH1 domain	0.1305	INHERITED FROM: trichostatin A
Interleukin 8-like chemokines	0.1312	INHERITED FROM: Benzylammonium Compounds || Gadolinium DTPA || methylbenzethonium chloride || Benzylamines || Ethylamines || Phenethylamines || 4-aminobenzhydrazide || Pentetic Acid || Benzalkonium Compounds || Albuterol || Sulfapyridine || 7-bromoindirubin-3'-oxime || Benzethonium || Catecholamines || Phenylenediamines || Sulfanilamides || 2-anisidine || Isoproterenol || N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine || Oximes || butenafine || roflumilast N-oxide || Roflumilast
Nucleotide cyclase	0.1356	INHERITED FROM: Ethylenediamines || Methapyrilene || Aminopyridines || Diamines
Sema domain	0.1412	INHERITED FROM: belinostat
GST C-terminal domain-like	0.1484	INHERITED FROM: Dihydroxyphenylalanine || Fenamates || Cysteinyldopa
Periplasmic binding protein-like II	0.1498	INHERITED FROM: Citalopram || Propylamines
Ras GEF	0.1644	INHERITED FROM: Methapyrilene
Ferritin-like	0.171	INHERITED FROM: Phenylenediamines
Metallothionein	0.176	INHERITED FROM: Ethylenediamines || Polyamines || Phenylenediamines || Niclosamide || Salicylanilides || N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine || Diamines
Leukotriene A4 hydrolase N-terminal domain	0.176	INHERITED FROM: 2-Naphthylamine
UDP-Glycosyltransferase/glycogen phosphorylase	0.192	INHERITED FROM: Furosemide || Sulfanilamides || Carbanilides || triclocarban || Fenamates
PYP-like sensor domain (PAS domain)	0.1927	INHERITED FROM: Ethylamines || Catecholamines || 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine || Isoproterenol || Oximes
TIMP-like	0.2172	INHERITED FROM: Catecholamines || Isoproterenol
ABC transporter transmembrane region	0.2522	INHERITED FROM: Ethylamines || Metaproterenol || Phenethylamines || Propanolamines || Catecholamines || Sulfanilamides || 6-bromoindirubin-3'-oxime || Verapamil || Isoproterenol || Oximes || 4'-methoxy-1-naphthylfenoterol
dsRNA-binding domain-like	0.2522	INHERITED FROM: beta-methylcholine || Trimethyl Ammonium Compounds || Choline
C2 domain (Calcium/lipid-binding domain, CaLB)	0.266	INHERITED FROM: Ethylenediamines || Polyamines || Aminopyridines || Diamines
MIR domain	0.2686	INHERITED FROM: Vorinostat
TNF receptor-like	0.3076	INHERITED FROM: HhAntag691 || 2-anisidine
Regulator of G-protein signaling, RGS	0.3211	INHERITED FROM: Propanolamines
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0.3313	INHERITED FROM: Egtazic Acid || Dopamine
A DNA-binding domain in eukaryotic transcription factors	0.3355	INHERITED FROM: Ethylamines || Phenethylamines || Phenylenediamines || Sertraline || 1-Naphthylamine || Amphetamine
ClpP/crotonase	0.3505	INHERITED FROM: 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime
Voltage-gated potassium channels	0.3648	INHERITED FROM: Niflumic Acid || ezogabine || Propanolamines || Propranolol || Flufenamic Acid || Verapamil || Tetraethylammonium Compounds || Lidocaine || Mexiletine
N-terminal nucleophile aminohydrolases (Ntn hydrolases)	0.3748	INHERITED FROM: EGFR tyrosine kinase inhibitor 324674
MFS general substrate transporter	0.3946	INHERITED FROM: talinolol || Norepinephrine || Phenacetin || Ethylamines || Etilefrine || Propanolamines || Furosemide || 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide || Serotonin || Methylamines || Propranolol || Tetraethylammonium Compounds || Lidocaine || Diphenhydramine || Fenamates
Inhibitor of apoptosis (IAP) repeat	0.3946	INHERITED FROM: EKB 569 || NVP-BKM120 || Crizotinib
Thioredoxin-like	0.4081	INHERITED FROM: Dihydroxyphenylalanine || trioctylmethylammonium || fluazinam || Fenamates || Cysteinyldopa || didecyldimethylammonium
Ribosomal protein S5 domain 2-like	0.4126	INHERITED FROM: Egtazic Acid
Toll/Interleukin receptor TIR domain	0.4431	INHERITED FROM: 7-bromoindirubin-3'-oxime || 2-anisidine
Cation efflux protein transmembrane domain-like	0.458	INHERITED FROM: N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine
Flavoproteins	0.5281	INHERITED FROM: Biogenic Monoamines || Biogenic Amines || Fenamates
Thioesterase/thiol ester dehydrase-isomerase	0.5281	INHERITED FROM: 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime || Oximes
Periplasmic binding protein-like I	0.533	INHERITED FROM: Citalopram || Propylamines
DBL homology domain (DH-domain)	0.5352	INHERITED FROM: Ethylenediamines || Polyamines || Aminopyridines || Diamines
Retrovirus zinc finger-like domains	0.5862	INHERITED FROM: beta-methylcholine
Hemopexin-like domain	0.5862	INHERITED FROM: 4-(4-(4-fluorophenoxy)benzenesulfonylamino)tetrahydropyran-4-carboxylic acid hydroxyamide || Mercaptoethylamines || Ethylamines || Egtazic Acid || CGS 27023A || 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine || Cysteamine
p53-like transcription factors	0.6036	INHERITED FROM: Spermidine || A 771726 || Norepinephrine || N(1),N(11)-diethylnorspermine || Edetic Acid || Putrescine || Biogenic Monoamines || Niclosamide || 2-anisidine || Salicylanilides || N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine || 1-Naphthylamine || Biogenic Amines || Spermine
Concanavalin A-like lectins/glucanases	0.6062	INHERITED FROM: Panobinostat
PGBD-like	0.6175	INHERITED FROM: 4-(4-(4-fluorophenoxy)benzenesulfonylamino)tetrahydropyran-4-carboxylic acid hydroxyamide || Mercaptoethylamines || Ethylamines || Egtazic Acid || Propanolamines || CGS 27023A || 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine || Cysteamine
Lipocalins	0.6217	INHERITED FROM: 1-anilino-8-naphthalenesulfonate || Anilino Naphthalenesulfonates
Metalloproteases ("zincins"), catalytic domain	0.6385	INHERITED FROM: 4-(4-(4-fluorophenoxy)benzenesulfonylamino)tetrahydropyran-4-carboxylic acid hydroxyamide || Ethylenediamines || Mercaptoethylamines || Diphenylamine || Polyamines || CGS 27023A || Metoprolol || PD 0325901 || 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine || Diamines || Cysteamine
alpha/beta-Hydrolases	0.6407	INHERITED FROM: Acetylcholine || 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime || Oximes
Nicotinic receptor ligand binding domain-like	0.6527	INHERITED FROM: Acetylcholine || Ethylamines || Phenethylamines || Carbachol || Amphetamines || N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline || Tubocurarine || Biogenic Amines || N-Methyl-3,4-methylenedioxyamphetamine
Neurotransmitter-gated ion-channel transmembrane pore	0.6527	INHERITED FROM: Acetylcholine || Ethylamines || Phenethylamines || Carbachol || Amphetamines || N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline || Tubocurarine || Biogenic Amines || N-Methyl-3,4-methylenedioxyamphetamine
E set domains	0.693	INHERITED FROM: Biogenic Polyamines || 2-anisidine
NAD(P)-linked oxidoreductase	0.7262	INHERITED FROM: Meclofenamic Acid || Polyamines || cresidine || Flufenamic Acid || Phenylenediamines || Diamines || 3,4-dichloroaniline || Fenamates
TNF-like	0.745	INHERITED FROM: peroben || Diphenhydramine
Ankyrin repeat	0.7499	INHERITED FROM: EKB 569
Cystine-knot cytokines	0.7514	INHERITED FROM: 2-chloro-5-nitrobenzanilide
EF-hand	0.755	INHERITED FROM: Polyamines || Aminopyridines || Diamines
Nucleic acid-binding proteins	0.7637	INHERITED FROM: Quaternary Ammonium Compounds
Actin-like ATPase domain	0.7706	INHERITED FROM: Biogenic Monoamines || Catecholamines || indirubin-3'-monoxime || Biogenic Amines
L domain-like	0.7826	INHERITED FROM: Mercaptoethylamines || 2-acetamidoethanethiol || Cysteamine
SNF-like	0.7841	INHERITED FROM: Dextroamphetamine || 2-(4-bromo-2,5-dimethoxyphenyl)ethylamine || Norepinephrine || 2-(4-bromo-2,5-dimethoxyphenyl)-N-((2-methoxyphenyl)methyl)ethanamine || 4-fluoroamphetamine || indatraline || Ethylamines || phenethylamine || Phenethylamines || 4-methoxymethamphetamine || Octopamine || Cyclohexylamines || Amphetamines || Fluoxetine || Serotonin || Methylamines || Dopamine || Propylamines || 2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone || 5-(2-aminopropyl)benzofuran || Tyramine || Dimethoxyphenylethylamine || Methamphetamine || tryptamine || Tryptamines
FabD/lysophospholipase-like	0.8296	INHERITED FROM: 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime || Oximes
Homeodomain-like	0.9147	INHERITED FROM: belinostat || Chir 98014 || Panobinostat
TRAF domain-like	0.9207	INHERITED FROM: 2-anisidine
4-helical cytokines	0.9222	INHERITED FROM: Deferoxamine || Benzylammonium Compounds || Gadolinium DTPA || Benzylamines || Ethylamines || Egtazic Acid || 4-methylhistamine || Pentetic Acid || Propanolamines || Albuterol || 4-nitrososulfamethoxazole || 7-bromoindirubin-3'-oxime || Biogenic Monoamines || Catecholamines || Sulfanilamides || 2-anisidine || Isoproterenol || Oximes || Biogenic Amines || Histamine
Cytokine	0.972	INHERITED FROM: Benzylammonium Compounds || Benzalkonium Compounds || Isoproterenol
Histone-fold	0.9958	INHERITED FROM: OTX015 || N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine
Immunoglobulin	0.9989	INHERITED FROM: Benzylammonium Compounds || Benzalkonium Compounds
Family A G protein-coupled receptor-like	1	INHERITED FROM: Norepinephrine || 5-methylfurtrethonium || BRL 37344 || Ethylamines || furtrethonium || Octopamine || Epinephrine || N-methylhistamine || 1-(8-bromobenzo(1,2-b;4,5-b')difuran-4-yl)-2-aminopropane || Phenylammonium Compounds || Norfenfluramine || 1-(2-(3-methoxyphenyl)ethyl)phenoxy-3-(dimethylamino)-2-propanol || Bethanechol Compounds || Gallamine Triethiodide || cyanopindolol || 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate || Tyramine || Muscarine || Synephrine || methoctramine || (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride || Biogenic Amines
C-type lectin-like	1	INHERITED FROM: Nebivolol || Platelet Activating Factor

Supra-domain (Duplex) in N- to C-terminal order

Highlighted in gray are those with FDR>0.001

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
51735,50129 51735 - NAD(P)-binding Rossmann-fold domains 50129 - GroES-like	0	DIRECT
57581,57196 57581 - TB module/8-cys domain 57196 - EGF/Laminin	0	DIRECT
57581,57184 57581 - TB module/8-cys domain 57184 - Growth factor receptor domain	0	DIRECT
54160,54160 54160 - Chromo domain-like 54160 - Chromo domain-like	0	DIRECT
49562,48350 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48350 - GTPase activation domain, GAP	0	DIRECT
49265,53300 49265 - Fibronectin type III 53300 - vWA-like	0	DIRECT
51045,56204 51045 - WW domain 56204 - Hect, E3 ligase catalytic domain	0	DIRECT
103647,103647 103647 - TSP type-3 repeat 103647 - TSP type-3 repeat	0	DIRECT
57184,57581 57184 - Growth factor receptor domain 57581 - TB module/8-cys domain	0	DIRECT
117018,56091 117018 - ATP-dependent DNA ligase DNA-binding domain 56091 - DNA ligase/mRNA capping enzyme, catalytic domain	0	DIRECT
63748,82199 63748 - Tudor/PWWP/MBT 82199 - SET domain	0	DIRECT
56059,51246 56059 - Glutathione synthetase ATP-binding domain-like 51246 - Rudiment single hybrid motif	0	DIRECT
54826,51604 54826 - Enolase N-terminal domain-like 51604 - Enolase C-terminal domain-like	0	DIRECT
57184,57184 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain	0	DIRECT
46689,57667 46689 - Homeodomain-like 57667 - beta-beta-alpha zinc fingers	0	DIRECT
69065,54768 69065 - RNase III domain-like 54768 - dsRNA-binding domain-like	0	DIRECT
57184,82895 57184 - Growth factor receptor domain 82895 - TSP-1 type 1 repeat	0	DIRECT
52540,-7 52540 - P-loop containing nucleoside triphosphate hydrolases -7 - CATH	0	DIRECT
57667,90229 57667 - beta-beta-alpha zinc fingers 90229 - CCCH zinc finger	0	DIRECT
54236,50729 54236 - Ubiquitin-like 50729 - PH domain-like	0	DIRECT
117839,56399 117839 - WWE domain 56399 - ADP-ribosylation	0	DIRECT
57184,49854 57184 - Growth factor receptor domain 49854 - Spermadhesin, CUB domain	0	DIRECT
55486,49854 55486 - Metalloproteases ("zincins"), catalytic domain 49854 - Spermadhesin, CUB domain	0	DIRECT
74788,75632 74788 - Cullin repeat-like 75632 - Cullin homology domain	0	DIRECT
47095,47095 47095 - HMG-box 47095 - HMG-box	0	DIRECT
55550,50729 55550 - SH2 domain 50729 - PH domain-like	0	DIRECT
57889,50729 57889 - Cysteine-rich domain 50729 - PH domain-like	0	DIRECT
51419,50621 51419 - PLP-binding barrel 50621 - Alanine racemase C-terminal domain-like	0	DIRECT
49265,56496 49265 - Fibronectin type III 56496 - Fibrinogen C-terminal domain-like	0	DIRECT
81324,81327 81324 - Voltage-gated potassium channels 81327 - Small-conductance potassium channel	0	DIRECT
57424,49899 57424 - LDL receptor-like module 49899 - Concanavalin A-like lectins/glucanases	0	DIRECT
53300,69179 53300 - vWA-like 69179 - Integrin domains	0	DIRECT
103637,103637 103637 - CCHHC domain 103637 - CCHHC domain	0	DIRECT
53300,49265 53300 - vWA-like 49265 - Fibronectin type III	0	DIRECT
56645,47203 56645 - Acyl-CoA dehydrogenase NM domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like	0	DIRECT
50692,54585 50692 - ADC-like 54585 - Cdc48 domain 2-like	0	DIRECT
100934,100934 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
52540,48019 52540 - P-loop containing nucleoside triphosphate hydrolases 48019 - post-AAA+ oligomerization domain-like	0	DIRECT
55486,48371 55486 - Metalloproteases ("zincins"), catalytic domain 48371 - ARM repeat	0	DIRECT
46966,47473 46966 - Spectrin repeat 47473 - EF-hand	0	DIRECT
82895,57424 82895 - TSP-1 type 1 repeat 57424 - LDL receptor-like module	0	DIRECT
47576,140612 47576 - Calponin-homology domain, CH-domain 140612 - EB1 dimerisation domain-like	0	DIRECT
48371,49348 48371 - ARM repeat 49348 - Clathrin adaptor appendage domain	0	DIRECT
55753,47050 55753 - Actin depolymerizing proteins 47050 - VHP, Villin headpiece domain	0	DIRECT
53300,49899 53300 - vWA-like 49899 - Concanavalin A-like lectins/glucanases	0	DIRECT
50729,56112 50729 - PH domain-like 56112 - Protein kinase-like (PK-like)	0	DIRECT
56091,50249 56091 - DNA ligase/mRNA capping enzyme, catalytic domain 50249 - Nucleic acid-binding proteins	0	DIRECT
57492,74650 57492 - Trefoil 74650 - Galactose mutarotase-like	0	DIRECT
64268,49562 64268 - PX domain 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)	0	DIRECT
54928,90209 54928 - RNA-binding domain, RBD 90209 - Ran binding protein zinc finger-like	0	DIRECT
48726,82895 48726 - Immunoglobulin 82895 - TSP-1 type 1 repeat	0	DIRECT
56176,55103 56176 - FAD-binding/transporter-associated domain-like 55103 - FAD-linked oxidases, C-terminal domain	0	DIRECT
90193,90193 90193 - Notch domain 90193 - Notch domain	0	DIRECT
50156,52540 50156 - PDZ domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
50729,55550 50729 - PH domain-like 55550 - SH2 domain	0	DIRECT
49313,49899 49313 - Cadherin-like 49899 - Concanavalin A-like lectins/glucanases	0	DIRECT
55186,55681 55186 - ThrRS/AlaRS common domain 55681 - Class II aaRS and biotin synthetases	0	DIRECT
46785,158702 46785 - "Winged helix" DNA-binding domain 158702 - Sec63 N-terminal domain-like	0	DIRECT
51230,47005 51230 - Single hybrid motif 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	DIRECT
52540,51045 52540 - P-loop containing nucleoside triphosphate hydrolases 51045 - WW domain	0	DIRECT
100895,100895 100895 - Kazal-type serine protease inhibitors 100895 - Kazal-type serine protease inhibitors	0	DIRECT
47473,57610 47473 - EF-hand 57610 - Thyroglobulin type-1 domain	0	DIRECT
49899,63887 49899 - Concanavalin A-like lectins/glucanases 63887 - P-domain of calnexin/calreticulin	0	DIRECT
57414,57440 57414 - Hairpin loop containing domain-like 57440 - Kringle-like	0	DIRECT
47473,57889 47473 - EF-hand 57889 - Cysteine-rich domain	0	DIRECT
57196,90193 57196 - EGF/Laminin 90193 - Notch domain	0	DIRECT
55021,56534 55021 - ACT-like 56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains	0	DIRECT
103647,49899 103647 - TSP type-3 repeat 49899 - Concanavalin A-like lectins/glucanases	0	DIRECT
51905,55424 51905 - FAD/NAD(P)-binding domain 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0	DIRECT
54277,50156 54277 - CAD & PB1 domains 50156 - PDZ domain-like	0	DIRECT
82199,57903 82199 - SET domain 57903 - FYVE/PHD zinc finger	0	DIRECT
53850,53850 53850 - Periplasmic binding protein-like II 53850 - Periplasmic binding protein-like II	0	DIRECT
100920,100934 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
48403,48452 48403 - Ankyrin repeat 48452 - TPR-like	0	DIRECT
90209,90209 90209 - Ran binding protein zinc finger-like 90209 - Ran binding protein zinc finger-like	0	DIRECT
55550,57850 55550 - SH2 domain 57850 - RING/U-box	0	DIRECT
53732,52016 53732 - Aconitase iron-sulfur domain 52016 - LeuD/IlvD-like	0	DIRECT
54001,143791 54001 - Cysteine proteinases 143791 - DUSP-like	0	DIRECT
47676,46942 47676 - Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 46942 - Elongation factor TFIIS domain 2	0	DIRECT
57196,69687 57196 - EGF/Laminin 69687 - Integrin beta tail domain	0	DIRECT
102848,54236 102848 - NSFL1 (p97 ATPase) cofactor p47, SEP domain 54236 - Ubiquitin-like	0	DIRECT
48403,50044 48403 - Ankyrin repeat 50044 - SH3-domain	0	DIRECT
141673,50800 141673 - MOSC N-terminal domain-like 50800 - PK beta-barrel domain-like	0	DIRECT
52980,47781 52980 - Restriction endonuclease-like 47781 - RuvA domain 2-like	0	DIRECT
52540,47917 52540 - P-loop containing nucleoside triphosphate hydrolases 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
75632,46785 75632 - Cullin homology domain 46785 - "Winged helix" DNA-binding domain	0	DIRECT
47473,55550 47473 - EF-hand 55550 - SH2 domain	0	DIRECT
54160,52540 54160 - Chromo domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
57903,63748 57903 - FYVE/PHD zinc finger 63748 - Tudor/PWWP/MBT	0	DIRECT
50729,50156 50729 - PH domain-like 50156 - PDZ domain-like	0	DIRECT
54637,54637 54637 - Thioesterase/thiol ester dehydrase-isomerase 54637 - Thioesterase/thiol ester dehydrase-isomerase	0	DIRECT
53738,55957 53738 - Phosphoglucomutase, first 3 domains 55957 - Phosphoglucomutase, C-terminal domain	0	DIRECT
47203,47203 47203 - Acyl-CoA dehydrogenase C-terminal domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like	0	DIRECT
102712,-7 102712 - JAB1/MPN domain -7 - CATH	0	DIRECT
50677,52374 50677 - ValRS/IleRS/LeuRS editing domain 52374 - Nucleotidylyl transferase	0	DIRECT
52096,52096 52096 - ClpP/crotonase 52096 - ClpP/crotonase	0	DIRECT
90188,90188 90188 - Somatomedin B domain 90188 - Somatomedin B domain	0	DIRECT
57889,48350 57889 - Cysteine-rich domain 48350 - GTPase activation domain, GAP	0	DIRECT
82109,82109 82109 - MIR domain 82109 - MIR domain	0	DIRECT
52058,52047 52058 - L domain-like 52047 - RNI-like	0	DIRECT
47353,109640 47353 - Retrovirus capsid dimerization domain-like 109640 - KRAB domain (Kruppel-associated box)	0	DIRECT
57535,49854 57535 - Complement control module/SCR domain 49854 - Spermadhesin, CUB domain	0	DIRECT
57667,140996 57667 - beta-beta-alpha zinc fingers 140996 - Hermes dimerisation domain	0	DIRECT
47986,47986 47986 - DEATH domain 47986 - DEATH domain	0	DIRECT
47668,47473 47668 - N-terminal domain of cbl (N-cbl) 47473 - EF-hand	0	DIRECT
53223,51735 53223 - Aminoacid dehydrogenase-like, N-terminal domain 51735 - NAD(P)-binding Rossmann-fold domains	0	DIRECT
53784,53784 53784 - Phosphofructokinase 53784 - Phosphofructokinase	0	DIRECT
-7,56112 -7 - CATH 56112 - Protein kinase-like (PK-like)	0	DIRECT
53328,50486 53328 - Formyltransferase 50486 - FMT C-terminal domain-like	0	DIRECT
103657,48350 103657 - BAR/IMD domain-like 48350 - GTPase activation domain, GAP	0	DIRECT
51556,51338 51556 - Metallo-dependent hydrolases 51338 - Composite domain of metallo-dependent hydrolases	0	DIRECT
49410,50242 49410 - Alpha-macroglobulin receptor domain 50242 - TIMP-like	0	DIRECT
48350,55961 48350 - GTPase activation domain, GAP 55961 - Bet v1-like	0	DIRECT
49899,57424 49899 - Concanavalin A-like lectins/glucanases 57424 - LDL receptor-like module	0	DIRECT
52047,48371 52047 - RNI-like 48371 - ARM repeat	0	DIRECT
53901,53901 53901 - Thiolase-like 53901 - Thiolase-like	0	DIRECT
56672,100879 56672 - DNA/RNA polymerases 100879 - Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
63748,63748 63748 - Tudor/PWWP/MBT 63748 - Tudor/PWWP/MBT	0	DIRECT
82109,100909 82109 - MIR domain 100909 - IP3 receptor type 1 binding core, domain 2	0	DIRECT
48371,101447 48371 - ARM repeat 101447 - Formin homology 2 domain (FH2 domain)	0	DIRECT
81271,55186 81271 - TGS-like 55186 - ThrRS/AlaRS common domain	0	DIRECT
51338,51556 51338 - Composite domain of metallo-dependent hydrolases 51556 - Metallo-dependent hydrolases	0	DIRECT
64268,50044 64268 - PX domain 50044 - SH3-domain	0	DIRECT
49417,47719 49417 - p53-like transcription factors 47719 - p53 tetramerization domain	0	DIRECT
57924,57924 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat	0	DIRECT
49562,57889 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 57889 - Cysteine-rich domain	0	DIRECT
50044,48350 50044 - SH3-domain 48350 - GTPase activation domain, GAP	0	DIRECT
53098,56672 53098 - Ribonuclease H-like 56672 - DNA/RNA polymerases	0	DIRECT
48403,56112 48403 - Ankyrin repeat 56112 - Protein kinase-like (PK-like)	0	DIRECT
47005,52777 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex 52777 - CoA-dependent acyltransferases	0	DIRECT
50729,46785 50729 - PH domain-like 46785 - "Winged helix" DNA-binding domain	0	DIRECT
63501,50242 63501 - Frizzled cysteine-rich domain 50242 - TIMP-like	0	DIRECT
53098,54928 53098 - Ribonuclease H-like 54928 - RNA-binding domain, RBD	0	DIRECT
50993,53474 50993 - Peptidase/esterase 'gauge' domain 53474 - alpha/beta-Hydrolases	0	DIRECT
48366,47473 48366 - Ras GEF 47473 - EF-hand	0	DIRECT
57196,57581 57196 - EGF/Laminin 57581 - TB module/8-cys domain	0	DIRECT
46785,54928 46785 - "Winged helix" DNA-binding domain 54928 - RNA-binding domain, RBD	0	DIRECT
54236,57889 54236 - Ubiquitin-like 57889 - Cysteine-rich domain	0	DIRECT
51905,47576 51905 - FAD/NAD(P)-binding domain 47576 - Calponin-homology domain, CH-domain	0	DIRECT
90188,53649 90188 - Somatomedin B domain 53649 - Alkaline phosphatase-like	0	DIRECT
50447,54980 50447 - Translation proteins 54980 - EF-G C-terminal domain-like	0	DIRECT
57603,57603 57603 - FnI-like domain 57603 - FnI-like domain	0	DIRECT
56112,50729 56112 - Protein kinase-like (PK-like) 50729 - PH domain-like	0	DIRECT
53738,53738 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains	0	DIRECT
48726,56112 48726 - Immunoglobulin 56112 - Protein kinase-like (PK-like)	0	DIRECT
54511,57184 54511 - GFP-like 57184 - Growth factor receptor domain	0	DIRECT
52440,56059 52440 - PreATP-grasp domain 56059 - Glutathione synthetase ATP-binding domain-like	0	DIRECT
52540,57774 52540 - P-loop containing nucleoside triphosphate hydrolases 57774 - Microbial and mitochondrial ADK, insert "zinc finger" domain	0	DIRECT
103025,101790 103025 - Folate-binding domain 101790 - Aminomethyltransferase beta-barrel domain	0	DIRECT
57581,57581 57581 - TB module/8-cys domain 57581 - TB module/8-cys domain	0	DIRECT
55550,55550 55550 - SH2 domain 55550 - SH2 domain	0	DIRECT
54403,54403 54403 - Cystatin/monellin 54403 - Cystatin/monellin	0	DIRECT
56112,64268 56112 - Protein kinase-like (PK-like) 64268 - PX domain	0	DIRECT
103575,81296 103575 - Plexin repeat 81296 - E set domains	0	DIRECT
56491,89811 56491 - A heparin-binding domain 89811 - Amyloid beta a4 protein copper binding domain (domain 2)	0	DIRECT
74924,74924 74924 - Cap-Gly domain 74924 - Cap-Gly domain	0	DIRECT
81324,53850 81324 - Voltage-gated potassium channels 53850 - Periplasmic binding protein-like II	0	DIRECT
57716,48508 57716 - Glucocorticoid receptor-like (DNA-binding domain) 48508 - Nuclear receptor ligand-binding domain	0.0001229	DIRECT
82895,82895 82895 - TSP-1 type 1 repeat 82895 - TSP-1 type 1 repeat	0.0001239	DIRECT
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin	0.0005539	DIRECT
57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain)	0.001358	INHERITED FROM: Hydroxamic Acids || Panobinostat
50129,51735 50129 - GroES-like 51735 - NAD(P)-binding Rossmann-fold domains	0.004802	INHERITED FROM: Acetaminophen
57184,57196 57184 - Growth factor receptor domain 57196 - EGF/Laminin	0.006465	INHERITED FROM: Methapyrilene
49265,49265 49265 - Fibronectin type III 49265 - Fibronectin type III	0.007171	INHERITED FROM: Ethylenediamines || Diamines
47954,47954 47954 - Cyclin-like 47954 - Cyclin-like	0.01978	INHERITED FROM: Deferoxamine || A 771726 || scriptaid || abemaciclib || Fluoxetine || Niclosamide || erucylphospho-N,N,N-trimethylpropylammonium || Quaternary Ammonium Compounds || Salicylanilides
57535,57535 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain	0.02363	INHERITED FROM: Platelet Activating Factor
54452,48726 54452 - MHC antigen-recognition domain 48726 - Immunoglobulin	0.03057	INHERITED FROM: Benzylammonium Compounds || Benzalkonium Compounds
69179,69179 69179 - Integrin domains 69179 - Integrin domains	0.04298	INHERITED FROM: Ethylenediamines || Diamines
69318,69179 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains	0.04298	INHERITED FROM: Ethylenediamines || Diamines
52821,52799 52821 - Rhodanese/Cell cycle control phosphatase 52799 - (Phosphotyrosine protein) phosphatases II	0.05604	INHERITED FROM: Sertraline || 1-Naphthylamine
57196,57184 57196 - EGF/Laminin 57184 - Growth factor receptor domain	0.07067	INHERITED FROM: belinostat
49417,81296 49417 - p53-like transcription factors 81296 - E set domains	0.07459	INHERITED FROM: Norepinephrine || Biogenic Monoamines || Catecholamines || Niclosamide || 2-anisidine || Salicylanilides || 1-Naphthylamine || Biogenic Amines
47459,158457 47459 - HLH, helix-loop-helix DNA-binding domain 158457 - Orange domain-like	0.07459	INHERITED FROM: Niclosamide || Salicylanilides
53067,100920 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain	0.07459	INHERITED FROM: Deferoxamine || Hydroxylamines || Biogenic Monoamines || Catecholamines || indirubin-3'-monoxime || Isoproterenol || Oximes || Biogenic Amines
47986,52129 47986 - DEATH domain 52129 - Caspase-like	0.09881	INHERITED FROM: Deferoxamine || Ethylenediamines || Vorinostat || Ethylamines || Egtazic Acid || Phenethylamines || LAQ824 || Melatonin || Biogenic Monoamines || Verapamil || Diamines || Biogenic Amines || Tryptamines
57586,57586 57586 - TNF receptor-like 57586 - TNF receptor-like	0.1111	INHERITED FROM: HhAntag691 || Anilides || 2-anisidine
56112,47769 56112 - Protein kinase-like (PK-like) 47769 - SAM/Pointed domain	0.113	INHERITED FROM: belinostat
48726,49265 48726 - Immunoglobulin 49265 - Fibronectin type III	0.1328	INHERITED FROM: Ethylenediamines || Methapyrilene || Diamines
101912,103575 101912 - Sema domain 103575 - Plexin repeat	0.1412	INHERITED FROM: belinostat
50044,48065 50044 - SH3-domain 48065 - DBL homology domain (DH-domain)	0.171	INHERITED FROM: Ethylenediamines || Polyamines || Diamines
48097,56112 48097 - Regulator of G-protein signaling, RGS 56112 - Protein kinase-like (PK-like)	0.171	INHERITED FROM: Propanolamines
52058,57184 52058 - L domain-like 57184 - Growth factor receptor domain	0.171	INHERITED FROM: Mercaptoethylamines || Ethylamines || 2-acetamidoethanethiol || Cysteamine
57184,52058 57184 - Growth factor receptor domain 52058 - L domain-like	0.171	INHERITED FROM: Mercaptoethylamines || Ethylamines || 2-acetamidoethanethiol || Cysteamine
63737,55486 63737 - Leukotriene A4 hydrolase N-terminal domain 55486 - Metalloproteases ("zincins"), catalytic domain	0.176	INHERITED FROM: 2-Naphthylamine
49785,57184 49785 - Galactose-binding domain-like 57184 - Growth factor receptor domain	0.176	INHERITED FROM: belinostat
54928,54928 54928 - RNA-binding domain, RBD 54928 - RNA-binding domain, RBD	0.2103	INHERITED FROM: Hydroxamic Acids
103575,48726 103575 - Plexin repeat 48726 - Immunoglobulin	0.2185	INHERITED FROM: belinostat || Vorinostat
90123,52540 90123 - ABC transporter transmembrane region 52540 - P-loop containing nucleoside triphosphate hydrolases	0.2522	INHERITED FROM: Ethylamines || Metaproterenol || Phenethylamines || Propanolamines || Catecholamines || Sulfanilamides || 6-bromoindirubin-3'-oxime || Verapamil || Isoproterenol || Oximes || 4'-methoxy-1-naphthylfenoterol
52540,90123 52540 - P-loop containing nucleoside triphosphate hydrolases 90123 - ABC transporter transmembrane region	0.3265	INHERITED FROM: Ethylamines || Phenethylamines || Catecholamines || Verapamil || Oximes
55785,55785 55785 - PYP-like sensor domain (PAS domain) 55785 - PYP-like sensor domain (PAS domain)	0.3265	INHERITED FROM: Deferoxamine || Biogenic Monoamines || Biogenic Amines
47459,55785 47459 - HLH, helix-loop-helix DNA-binding domain 55785 - PYP-like sensor domain (PAS domain)	0.3351	INHERITED FROM: Deferoxamine || Ethylamines || Catecholamines || Isoproterenol
52833,47616 52833 - Thioredoxin-like 47616 - GST C-terminal domain-like	0.3585	INHERITED FROM: Dihydroxyphenylalanine || Catecholamines || Fenamates || Cysteinyldopa
48065,50729 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like	0.3766	INHERITED FROM: Ethylenediamines || Polyamines || Aminopyridines || Diamines
47454,57959 47454 - A DNA-binding domain in eukaryotic transcription factors 57959 - Leucine zipper domain	0.3899	INHERITED FROM: Ethylamines || Phenethylamines || Phenylenediamines || Sertraline || 1-Naphthylamine || Amphetamine
48726,56436 48726 - Immunoglobulin 56436 - C-type lectin-like	0.3946	INHERITED FROM: belinostat
57440,57440 57440 - Kringle-like 57440 - Kringle-like	0.4127	INHERITED FROM: 2-chloro-5-nitrobenzanilide || Norepinephrine || Ethylamines || Phenethylamines || Propanolamines || Biogenic Monoamines || Propranolol || Catecholamines || Niclosamide || Sphingosine || Salicylanilides || Isoproterenol || Biogenic Amines
47986,52540 47986 - DEATH domain 52540 - P-loop containing nucleoside triphosphate hydrolases	0.4418	INHERITED FROM: Ethylenediamines || Polyamines || Methapyrilene || Aminopyridines || Diamines
81324,81324 81324 - Voltage-gated potassium channels 81324 - Voltage-gated potassium channels	0.4509	INHERITED FROM: Niflumic Acid || Mefenamic Acid || Flufenamic Acid || Fenamates
47090,55486 47090 - PGBD-like 55486 - Metalloproteases ("zincins"), catalytic domain	0.6175	INHERITED FROM: 4-(4-(4-fluorophenoxy)benzenesulfonylamino)tetrahydropyran-4-carboxylic acid hydroxyamide || Mercaptoethylamines || Ethylamines || Egtazic Acid || Propanolamines || CGS 27023A || 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine || Cysteamine
63712,90112 63712 - Nicotinic receptor ligand binding domain-like 90112 - Neurotransmitter-gated ion-channel transmembrane pore	0.6527	INHERITED FROM: Acetylcholine || Ethylamines || Phenethylamines || Carbachol || Amphetamines || N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline || Tubocurarine || Biogenic Amines || N-Methyl-3,4-methylenedioxyamphetamine
53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain	0.7229	INHERITED FROM: Biogenic Monoamines || Catecholamines || indirubin-3'-monoxime || Biogenic Amines
55486,50923 55486 - Metalloproteases ("zincins"), catalytic domain 50923 - Hemopexin-like domain	0.8296	INHERITED FROM: CGS 27023A
57850,49599 57850 - RING/U-box 49599 - TRAF domain-like	0.8305	INHERITED FROM: 2-anisidine
81324,81296 81324 - Voltage-gated potassium channels 81296 - E set domains	0.8772	INHERITED FROM: Propanolamines

Supra-domain (Triple) in N- to C-terminal order

Highlighted in gray are those with FDR>0.001

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
53300,53300,53300 53300 - vWA-like 53300 - vWA-like 53300 - vWA-like	0	DIRECT
100895,100895,100895 100895 - Kazal-type serine protease inhibitors 100895 - Kazal-type serine protease inhibitors 100895 - Kazal-type serine protease inhibitors	0	DIRECT
47986,47986,52129 47986 - DEATH domain 47986 - DEATH domain 52129 - Caspase-like	0	DIRECT
52058,48726,48726 52058 - L domain-like 48726 - Immunoglobulin 48726 - Immunoglobulin	0	DIRECT
51045,51045,56204 51045 - WW domain 51045 - WW domain 56204 - Hect, E3 ligase catalytic domain	0	DIRECT
90229,90229,90229 90229 - CCCH zinc finger 90229 - CCCH zinc finger 90229 - CCCH zinc finger	0	DIRECT
55486,49854,49854 55486 - Metalloproteases ("zincins"), catalytic domain 49854 - Spermadhesin, CUB domain 49854 - Spermadhesin, CUB domain	0	DIRECT
48726,82895,82895 48726 - Immunoglobulin 82895 - TSP-1 type 1 repeat 82895 - TSP-1 type 1 repeat	0	DIRECT
55186,55681,52954 55186 - ThrRS/AlaRS common domain 55681 - Class II aaRS and biotin synthetases 52954 - Class II aaRS ABD-related	0	DIRECT
57924,57924,57924 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat	0	DIRECT
57414,57440,57440 57414 - Hairpin loop containing domain-like 57440 - Kringle-like 57440 - Kringle-like	0	DIRECT
55550,56112,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) 56112 - Protein kinase-like (PK-like)	0	DIRECT
103647,103647,103647 103647 - TSP type-3 repeat 103647 - TSP type-3 repeat 103647 - TSP type-3 repeat	0	DIRECT
57184,57184,57581 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain 57581 - TB module/8-cys domain	0	DIRECT
57196,57196,57581 57196 - EGF/Laminin 57196 - EGF/Laminin 57581 - TB module/8-cys domain	0	DIRECT
57184,52058,57184 57184 - Growth factor receptor domain 52058 - L domain-like 57184 - Growth factor receptor domain	0	DIRECT
57196,49854,49854 57196 - EGF/Laminin 49854 - Spermadhesin, CUB domain 49854 - Spermadhesin, CUB domain	0	DIRECT
51338,51556,51338 51338 - Composite domain of metallo-dependent hydrolases 51556 - Metallo-dependent hydrolases 51338 - Composite domain of metallo-dependent hydrolases	0	DIRECT
53738,53738,55957 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains 55957 - Phosphoglucomutase, C-terminal domain	0	DIRECT
103657,50729,48350 103657 - BAR/IMD domain-like 50729 - PH domain-like 48350 - GTPase activation domain, GAP	0	DIRECT
57581,57184,57184 57581 - TB module/8-cys domain 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain	0	DIRECT
50129,51735,50129 50129 - GroES-like 51735 - NAD(P)-binding Rossmann-fold domains 50129 - GroES-like	0	DIRECT
48726,48726,82895 48726 - Immunoglobulin 48726 - Immunoglobulin 82895 - TSP-1 type 1 repeat	0	DIRECT
50156,52540,51045 50156 - PDZ domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases 51045 - WW domain	0	DIRECT
54160,52540,52540 54160 - Chromo domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
57492,74650,51445 57492 - Trefoil 74650 - Galactose mutarotase-like 51445 - (Trans)glycosidases	0	DIRECT
81271,55186,55681 81271 - TGS-like 55186 - ThrRS/AlaRS common domain 55681 - Class II aaRS and biotin synthetases	0	DIRECT
57196,57581,57196 57196 - EGF/Laminin 57581 - TB module/8-cys domain 57196 - EGF/Laminin	0	DIRECT
57581,57196,57196 57581 - TB module/8-cys domain 57196 - EGF/Laminin 57196 - EGF/Laminin	0	DIRECT
49313,49313,49899 49313 - Cadherin-like 49313 - Cadherin-like 49899 - Concanavalin A-like lectins/glucanases	0	DIRECT
48366,47473,57889 48366 - Ras GEF 47473 - EF-hand 57889 - Cysteine-rich domain	0	DIRECT
50978,50978,50978 50978 - WD40 repeat-like 50978 - WD40 repeat-like 50978 - WD40 repeat-like	0	DIRECT
74788,75632,46785 74788 - Cullin repeat-like 75632 - Cullin homology domain 46785 - "Winged helix" DNA-binding domain	0	DIRECT
57581,57196,57581 57581 - TB module/8-cys domain 57196 - EGF/Laminin 57581 - TB module/8-cys domain	0	DIRECT
49265,49265,53300 49265 - Fibronectin type III 49265 - Fibronectin type III 53300 - vWA-like	0	DIRECT
57184,57581,57184 57184 - Growth factor receptor domain 57581 - TB module/8-cys domain 57184 - Growth factor receptor domain	0	DIRECT
50729,49562,48350 50729 - PH domain-like 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48350 - GTPase activation domain, GAP	0	DIRECT
56112,64268,49562 56112 - Protein kinase-like (PK-like) 64268 - PX domain 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)	0	DIRECT
57581,57184,57581 57581 - TB module/8-cys domain 57184 - Growth factor receptor domain 57581 - TB module/8-cys domain	0	DIRECT
47473,57889,57889 47473 - EF-hand 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain	0	DIRECT
50729,50156,50156 50729 - PH domain-like 50156 - PDZ domain-like 50156 - PDZ domain-like	0	DIRECT
57184,57184,57184 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain	0	DIRECT
52540,46785,158702 52540 - P-loop containing nucleoside triphosphate hydrolases 46785 - "Winged helix" DNA-binding domain 158702 - Sec63 N-terminal domain-like	0	DIRECT
47473,47473,57889 47473 - EF-hand 47473 - EF-hand 57889 - Cysteine-rich domain	0	DIRECT
103637,103637,103637 103637 - CCHHC domain 103637 - CCHHC domain 103637 - CCHHC domain	0	DIRECT
57603,57603,57603 57603 - FnI-like domain 57603 - FnI-like domain 57603 - FnI-like domain	0	DIRECT
49854,57535,49854 49854 - Spermadhesin, CUB domain 57535 - Complement control module/SCR domain 49854 - Spermadhesin, CUB domain	0	DIRECT
57184,57581,57196 57184 - Growth factor receptor domain 57581 - TB module/8-cys domain 57196 - EGF/Laminin	0	DIRECT
57196,57196,90193 57196 - EGF/Laminin 57196 - EGF/Laminin 90193 - Notch domain	0	DIRECT
47473,55550,57850 47473 - EF-hand 55550 - SH2 domain 57850 - RING/U-box	0	DIRECT
103575,81296,81296 103575 - Plexin repeat 81296 - E set domains 81296 - E set domains	0	DIRECT
56645,47203,47203 56645 - Acyl-CoA dehydrogenase NM domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like 47203 - Acyl-CoA dehydrogenase C-terminal domain-like	0	DIRECT
49899,57424,49899 49899 - Concanavalin A-like lectins/glucanases 57424 - LDL receptor-like module 49899 - Concanavalin A-like lectins/glucanases	0	DIRECT
63748,82199,57903 63748 - Tudor/PWWP/MBT 82199 - SET domain 57903 - FYVE/PHD zinc finger	0	DIRECT
46966,46966,47473 46966 - Spectrin repeat 46966 - Spectrin repeat 47473 - EF-hand	0	DIRECT
55753,55753,47050 55753 - Actin depolymerizing proteins 55753 - Actin depolymerizing proteins 47050 - VHP, Villin headpiece domain	0	DIRECT
103647,103647,49899 103647 - TSP type-3 repeat 103647 - TSP type-3 repeat 49899 - Concanavalin A-like lectins/glucanases	0	DIRECT
49562,57889,57889 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain	0	DIRECT
53067,100920,100934 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
57184,57196,57184 57184 - Growth factor receptor domain 57196 - EGF/Laminin 57184 - Growth factor receptor domain	0	DIRECT
57184,57184,57196 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain 57196 - EGF/Laminin	0	DIRECT
48371,56112,64268 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) 64268 - PX domain	0	DIRECT
82109,82109,100909 82109 - MIR domain 82109 - MIR domain 100909 - IP3 receptor type 1 binding core, domain 2	0	DIRECT
52540,52540,46785 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases 46785 - "Winged helix" DNA-binding domain	0	DIRECT
50044,55550,50044 50044 - SH3-domain 55550 - SH2 domain 50044 - SH3-domain	0	DIRECT
54160,54160,52540 54160 - Chromo domain-like 54160 - Chromo domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
49785,57184,49265 49785 - Galactose-binding domain-like 57184 - Growth factor receptor domain 49265 - Fibronectin type III	0	DIRECT
46689,46689,46689 46689 - Homeodomain-like 46689 - Homeodomain-like 46689 - Homeodomain-like	0	DIRECT
57184,57581,57581 57184 - Growth factor receptor domain 57581 - TB module/8-cys domain 57581 - TB module/8-cys domain	0	DIRECT
57196,57184,57184 57196 - EGF/Laminin 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain	0	DIRECT
51045,51045,51045 51045 - WW domain 51045 - WW domain 51045 - WW domain	0	DIRECT
64268,50044,50044 64268 - PX domain 50044 - SH3-domain 50044 - SH3-domain	0	DIRECT
103473,103473,141571 103473 - MFS general substrate transporter 103473 - MFS general substrate transporter 141571 - Pentapeptide repeat-like	0	DIRECT
57903,63748,82199 57903 - FYVE/PHD zinc finger 63748 - Tudor/PWWP/MBT 82199 - SET domain	0	DIRECT
57535,49854,57535 57535 - Complement control module/SCR domain 49854 - Spermadhesin, CUB domain 57535 - Complement control module/SCR domain	0	DIRECT
63411,63411,63411 63411 - LuxS/MPP-like metallohydrolase 63411 - LuxS/MPP-like metallohydrolase 63411 - LuxS/MPP-like metallohydrolase	0	DIRECT
48065,50729,50729 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like 50729 - PH domain-like	0	DIRECT
53738,53738,53738 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains	0	DIRECT
52540,50447,54980 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins 54980 - EF-G C-terminal domain-like	0	DIRECT
50729,55550,56112 50729 - PH domain-like 55550 - SH2 domain 56112 - Protein kinase-like (PK-like)	0	DIRECT
51230,47005,52777 51230 - Single hybrid motif 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex 52777 - CoA-dependent acyltransferases	0	DIRECT
57586,57586,57586 57586 - TNF receptor-like 57586 - TNF receptor-like 57586 - TNF receptor-like	0	DIRECT
117018,56091,50249 117018 - ATP-dependent DNA ligase DNA-binding domain 56091 - DNA ligase/mRNA capping enzyme, catalytic domain 50249 - Nucleic acid-binding proteins	0	DIRECT
52440,56059,51246 52440 - PreATP-grasp domain 56059 - Glutathione synthetase ATP-binding domain-like 51246 - Rudiment single hybrid motif	0	DIRECT
48552,48552,48552 48552 - Serum albumin-like 48552 - Serum albumin-like 48552 - Serum albumin-like	0	DIRECT
57196,57196,69687 57196 - EGF/Laminin 57196 - EGF/Laminin 69687 - Integrin beta tail domain	0	DIRECT
100895,47473,57610 100895 - Kazal-type serine protease inhibitors 47473 - EF-hand 57610 - Thyroglobulin type-1 domain	0	DIRECT
90188,90188,53649 90188 - Somatomedin B domain 90188 - Somatomedin B domain 53649 - Alkaline phosphatase-like	0	DIRECT
63748,63748,63748 63748 - Tudor/PWWP/MBT 63748 - Tudor/PWWP/MBT 63748 - Tudor/PWWP/MBT	0	DIRECT
57196,57581,57184 57196 - EGF/Laminin 57581 - TB module/8-cys domain 57184 - Growth factor receptor domain	0	DIRECT
52540,51045,51045 52540 - P-loop containing nucleoside triphosphate hydrolases 51045 - WW domain 51045 - WW domain	0	DIRECT
47668,47473,55550 47668 - N-terminal domain of cbl (N-cbl) 47473 - EF-hand 55550 - SH2 domain	0	DIRECT
82895,82895,82895 82895 - TSP-1 type 1 repeat 82895 - TSP-1 type 1 repeat 82895 - TSP-1 type 1 repeat	0.0008054	DIRECT
57196,57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin 57196 - EGF/Laminin	0.006364	INHERITED FROM: Sphingosine
69318,69179,69179 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains 69179 - Integrin domains	0.04298	INHERITED FROM: Ethylenediamines || Diamines
69179,69179,69179 69179 - Integrin domains 69179 - Integrin domains 69179 - Integrin domains	0.07046	INHERITED FROM: Ethylenediamines
53067,53067,100920 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain	0.07459	INHERITED FROM: Deferoxamine || Hydroxylamines || Biogenic Monoamines || Catecholamines || indirubin-3'-monoxime || Isoproterenol || Oximes || Biogenic Amines
54928,54928,54928 54928 - RNA-binding domain, RBD 54928 - RNA-binding domain, RBD 54928 - RNA-binding domain, RBD	0.09881	INHERITED FROM: Panobinostat
48726,48726,49265 48726 - Immunoglobulin 48726 - Immunoglobulin 49265 - Fibronectin type III	0.1079	INHERITED FROM: Ethylenediamines || Methapyrilene || Diamines
47459,55785,55785 47459 - HLH, helix-loop-helix DNA-binding domain 55785 - PYP-like sensor domain (PAS domain) 55785 - PYP-like sensor domain (PAS domain)	0.1305	INHERITED FROM: Deferoxamine || Biogenic Monoamines || Biogenic Amines
52058,57184,52058 52058 - L domain-like 57184 - Growth factor receptor domain 52058 - L domain-like	0.171	INHERITED FROM: Mercaptoethylamines || Ethylamines || 2-acetamidoethanethiol || Cysteamine
50044,48065,50729 50044 - SH3-domain 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like	0.171	INHERITED FROM: Ethylenediamines || Polyamines || Diamines
101912,103575,48726 101912 - Sema domain 103575 - Plexin repeat 48726 - Immunoglobulin	0.2185	INHERITED FROM: belinostat || Vorinostat
57196,57196,57184 57196 - EGF/Laminin 57196 - EGF/Laminin 57184 - Growth factor receptor domain	0.2475	INHERITED FROM: Ethylenediamines || belinostat || Polyamines || Methapyrilene || Aminopyridines || Diamines
57850,49599,49599 57850 - RING/U-box 49599 - TRAF domain-like 49599 - TRAF domain-like	0.291	INHERITED FROM: 2-anisidine
52540,90123,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 90123 - ABC transporter transmembrane region 52540 - P-loop containing nucleoside triphosphate hydrolases	0.3265	INHERITED FROM: Ethylamines || Phenethylamines || Catecholamines || Verapamil || Oximes
90123,52540,90123 90123 - ABC transporter transmembrane region 52540 - P-loop containing nucleoside triphosphate hydrolases 90123 - ABC transporter transmembrane region	0.3265	INHERITED FROM: Ethylamines || Phenethylamines || Catecholamines || Verapamil || Oximes
48726,56436,56436 48726 - Immunoglobulin 56436 - C-type lectin-like 56436 - C-type lectin-like	0.3946	INHERITED FROM: belinostat
57440,57440,57440 57440 - Kringle-like 57440 - Kringle-like 57440 - Kringle-like	0.4379	INHERITED FROM: Ethylamines || Phenethylamines || Propanolamines || Sphingosine || sphingosine 1-phosphate
47090,55486,50923 47090 - PGBD-like 55486 - Metalloproteases ("zincins"), catalytic domain 50923 - Hemopexin-like domain	0.7787	INHERITED FROM: CGS 27023A