Saposin superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All alpha proteins [ 46456] (284)
• Fold: Saposin-like [ 47861] (2)
• Superfamily: Saposin [ 47862] (4)
• Families:
  • Saposin B [ 81806]
  • NKL-like [ 47863] (3)
  • Ameobapore A [ 101266]
  • Swaposin [ 47866]

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Superfamily statistics

	Genomes (253)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	3,342	9,114	9
Proteins	1,871	4,987	9

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Functional annotation

• General category: Processes_IC
• Detailed category: Protein modification

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Sphingomyelin phosphodiesterase	0	2.259	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.04271	--	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0.000003905	0.4665	Least Informative	DIRECT
Enzyme Commission (EC)	Phosphoric diester hydrolases	0.0000001042	1.162	Moderately Informative	DIRECT

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	disease of cellular proliferation	0	0.2812	--	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Mode of Inheritance (MI)	Autosomal recessive inheritance	0	0.1924	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0	0.4621	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal respiratory system morphology	0	1.106	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the cardiovascular system	0	0.6284	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of metabolism/homeostasis	0	0.5315	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of skeletal morphology	0	0.472	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the respiratory system	0	0.9294	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the vasculature	0	0.8625	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal lung morphology	0	1.365	Informative	DIRECT
Phenotypic Abnormality (PA)	Functional respiratory abnormality	0	1.407	Informative	DIRECT
Phenotypic Abnormality (PA)	Respiratory insufficiency	0	2.106	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	lethal	0	0.01121	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001706	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.004279	--	DIRECT
Worm Phenotype (WP)	increased pathogen survival	0.00000000000003527	2.708	--	DIRECT
Worm Phenotype (WP)	pathogen load variant	0.00000000127	2.708	--	DIRECT
Worm Phenotype (WP)	radiation induced germ cell apoptosis variant	0.000001751	2.23	--	DIRECT
Worm Phenotype (WP)	germ cell resistant ionizing radiation	0.00001294	2.23	--	DIRECT
Worm Phenotype (WP)	cell ionizing radiation response variant	0.002544	1.753	--	INHERITED FROM: germ cell ionizing radiation response variant || radiation induced germ cell apoptosis variant || germ cell resistant ionizing radiation
Worm Phenotype (WP)	transgene expression variant	0.005558	0.7938	--	INHERITED FROM: transgene expression reduced || level of transgene expression variant
Worm Phenotype (WP)	gene expression variant	0.02037	0.6038	--	INHERITED FROM: level of transgene expression variant || transgene expression reduced
Worm Phenotype (WP)	germ cell physiology variant	0.1426	1.26	--	INHERITED FROM: germ cell resistant ionizing radiation || radiation induced germ cell apoptosis variant || germ cell ionizing radiation response variant
Worm Phenotype (WP)	programmed cell death variant	0.2016	0.9594	--	INHERITED FROM: radiation induced germ cell apoptosis variant || mutagen induced apoptosis variant
Worm Phenotype (WP)	cell death variant	0.2239	0.9441	--	INHERITED FROM: radiation induced germ cell apoptosis variant || mutagen induced apoptosis variant
Worm Phenotype (WP)	reproductive system physiology variant	0.7837	0.07209	--	INHERITED FROM: germ cell resistant ionizing radiation || germ cell ionizing radiation response variant || radiation induced germ cell apoptosis variant
Worm Phenotype (WP)	organ system physiology variant	0.7867	0.05921	--	INHERITED FROM: radiation induced germ cell apoptosis variant || germ cell resistant ionizing radiation || germ cell ionizing radiation response variant
Worm Phenotype (WP)	behavior variant	0.8202	0.632	--	INHERITED FROM: fewer eggs laid
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.9479	0.1501	--	INHERITED FROM: germ cell ionizing radiation response variant || radiation induced germ cell apoptosis variant || level of transgene expression variant || transgene expression reduced || germ cell resistant ionizing radiation || increased pathogen survival || pathogen load variant
Worm Phenotype (WP)	organism physiology variant	0.9619	0.1405	--	INHERITED FROM: germ cell ionizing radiation response variant || radiation induced germ cell apoptosis variant || level of transgene expression variant || germ cell resistant ionizing radiation || transgene expression reduced || pathogen load variant || increased pathogen survival
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: transgene expression reduced || lethal || mutagen induced apoptosis variant || fewer eggs laid || development variant || increased pathogen survival || germ cell ionizing radiation response variant || germ cell resistant ionizing radiation || pathogen load variant || organism development variant || level of transgene expression variant || radiation induced germ cell apoptosis variant
Worm Phenotype (WP)	organism metabolism processing variant	0.06781	0.4572	Least Informative	INHERITED FROM: transgene expression reduced || level of transgene expression variant
Worm Phenotype (WP)	organism environmental stimulus response variant	0.1095	0.5677	Least Informative	INHERITED FROM: germ cell ionizing radiation response variant || germ cell resistant ionizing radiation || pathogen load variant || radiation induced germ cell apoptosis variant || increased pathogen survival
Worm Phenotype (WP)	organism behavior variant	0.8138	0.632	Least Informative	INHERITED FROM: fewer eggs laid
Worm Phenotype (WP)	cell physiology variant	1	0.5344	Least Informative	INHERITED FROM: germ cell ionizing radiation response variant || germ cell resistant ionizing radiation || mutagen induced apoptosis variant || radiation induced germ cell apoptosis variant
Worm Phenotype (WP)	level of transgene expression variant	0.000006782	1.151	Moderately Informative	DIRECT
Worm Phenotype (WP)	organism stress response variant	0.004527	0.8325	Moderately Informative	INHERITED FROM: pathogen load variant || radiation induced germ cell apoptosis variant || increased pathogen survival || germ cell ionizing radiation response variant || germ cell resistant ionizing radiation
Worm Phenotype (WP)	apoptosis variant	0.1746	1	Moderately Informative	INHERITED FROM: mutagen induced apoptosis variant || radiation induced germ cell apoptosis variant
Worm Phenotype (WP)	cell homeostasis metabolism variant	0.464	0.9294	Moderately Informative	INHERITED FROM: radiation induced germ cell apoptosis variant || germ cell ionizing radiation response variant || germ cell resistant ionizing radiation
Worm Phenotype (WP)	transgene expression reduced	0.0009418	1.628	Informative	DIRECT
Worm Phenotype (WP)	egg laying variant	0.02933	1.452	Informative	INHERITED FROM: fewer eggs laid
Worm Phenotype (WP)	organism ionizing radiation response variant	0.08195	1.708	Informative	INHERITED FROM: radiation induced germ cell apoptosis variant || germ cell ionizing radiation response variant || germ cell resistant ionizing radiation
Worm Phenotype (WP)	cell stress response variant	0.09039	1.407	Informative	INHERITED FROM: radiation induced germ cell apoptosis variant || germ cell ionizing radiation response variant || germ cell resistant ionizing radiation
Worm Phenotype (WP)	organism pathogen response variant	0.1801	1.365	Informative	INHERITED FROM: pathogen load variant || increased pathogen survival
Worm Phenotype (WP)	fewer eggs laid	0.000000001501	2.106	Highly Informative	DIRECT
Worm Phenotype (WP)	mutagen induced apoptosis variant	0.00001294	2.106	Highly Informative	DIRECT
Worm Phenotype (WP)	germ cell ionizing radiation response variant	0.0008987	1.929	Highly Informative	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	stomatal complex	0	0.2774	--	DIRECT
Plant ANatomical entity (PAN)	epidermal cell	0	0.2569	--	DIRECT
Plant ANatomical entity (PAN)	shoot internode	0	0.6463	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2464	--	DIRECT
Plant ANatomical entity (PAN)	phyllome	0	0.3809	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2691	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1489	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05747	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1892	--	DIRECT
Plant ANatomical entity (PAN)	plant organ	0	0.2816	--	DIRECT
Plant ANatomical entity (PAN)	vascular leaf	0	0.5246	--	DIRECT
Plant ANatomical entity (PAN)	stem	0	0.577	--	DIRECT
Plant ANatomical entity (PAN)	leaf apex	0	0.7094	--	DIRECT
Plant ANatomical entity (PAN)	stem internode	0	0.6495	--	DIRECT
Plant ANatomical entity (PAN)	cardinal organ part	0	0.51	--	DIRECT
Plant ANatomical entity (PAN)	plant axis	0	0.3881	--	DIRECT
Plant ANatomical entity (PAN)	collective leaf structure	0	0.55	--	DIRECT
Plant ANatomical entity (PAN)	reproductive shoot system	0	0.4141	--	DIRECT
Plant ANatomical entity (PAN)	phyllome apex	0	0.7019	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.276	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2691	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01577	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: flower || collective plant structure || leaf || shoot internode || phyllome || cardinal organ part || multi-tissue plant structure || guard cell || reproductive shoot system || leaf apex || collective leaf structure || stem internode || shoot system || portion of plant tissue || stomatal complex || plant organ || stem || epidermis || cardinal part of multi-tissue plant structure || vascular leaf || epidermal cell || shoot epidermal cell || plant axis || collective phyllome structure || plant cell || shoot epidermis || phyllome apex || shoot axis
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.04502	--	INHERITED FROM: flower || stem || leaf || phyllome || shoot internode || vascular leaf || reproductive shoot system || leaf apex || collective phyllome structure || guard cell || shoot epidermal cell || stomatal complex || phyllome apex || stem internode || shoot axis || shoot system || collective leaf structure || shoot epidermis
Plant ANatomical entity (PAN)	guard cell	0	0.2774	Least Informative	DIRECT
Plant ANatomical entity (PAN)	flower	0	0.4337	Least Informative	DIRECT
Plant ANatomical entity (PAN)	collective phyllome structure	0	0.4648	Least Informative	DIRECT
Plant ANatomical entity (PAN)	shoot axis	0	0.4735	Least Informative	DIRECT
Plant ANatomical entity (PAN)	leaf	0	0.5053	Least Informative	DIRECT
Plant ANatomical entity (PAN)	cardinal part of multi-tissue plant structure	0	0.5029	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	whole plant development stage	0	0.1968	--	DIRECT
Plant structure DEvelopment stage (PDE)	1 main shoot growth stage	0	0.3937	--	DIRECT
Plant structure DEvelopment stage (PDE)	leaf production stage	0	0.3937	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0	0.2036	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1981	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.03771	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.08108	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.05008	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.07083	--	INHERITED FROM: corolla development stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.2022	--	INHERITED FROM: sporophyte vegetative stage || leaf production stage || 1 main shoot growth stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.04053	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || corolla development stage || plant organ development stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.2022	--	INHERITED FROM: sporophyte vegetative stage || leaf production stage || 1 main shoot growth stage

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Sphingomyelin phosphodiesterase	0	2.651	--	DIRECT
Enzyme Commission (EC)	Acyloxyacyl hydrolase	2.574e-16	2.651	--	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0.000008629	0.7559	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.3541	Least Informative	DIRECT
Enzyme Commission (EC)	Phosphoric diester hydrolases	0.000000009605	1.46	Informative	DIRECT
Enzyme Commission (EC)	Carboxylic ester hydrolases	0.2506	1.408	Informative	INHERITED FROM: Acyloxyacyl hydrolase

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InterPro annotation

• Cross references: IPR011001 SSF47862 Protein matches
• Abstract:

  The lysosomal degradation of several sphingolipids requires the presence of four small glycoproteins called saposins, generated by proteolytic processing of a common precursor, prosaposin [9972880]. Saposins have three conserved disulphide bridges, and display a 5-helical, closed, folded leaf topology. Other proteins have been shown to have structures that closely resemble saposin, such as the antimicrobial peptides NK-lysin and granulysin [8988855, 14499265]. Some proteins contain saposin-like domains, such as prophytepsin, an acid protease from plants, and J3-crystallin, an eye-lens protein from jellyfish, both of which contain circularly permuted saposin motifs called swaposin [10406799, 11675486]. In some saposins and saposin-like domains, lipid-binding can promote conformational changes and oligomerization.

InterPro database

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