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Phosphotyrosine-binding domain (PTB) family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   PH domain-like barrel [ 50728] (2)
Superfamily:   PH domain-like [ 50729] (13)
Family:   Phosphotyrosine-binding domain (PTB) [ 50755] (12)

Family statistics
Genomes (147) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 2,941 8,523 19
Proteins 2,816 8,254 18

Disease Ontology (DO)

show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)gonadal disease0.006323Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.3624Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.4584Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal homeostasis0.505Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal glucose homeostasis0.06759InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.09873Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.1518Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.4951Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.7707Least InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.000976Moderately InformativeDirect
Mammalian Phenotype (MP)adipose tissue phenotype0.002865Moderately InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.004353Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.03102Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal synaptic transmission0.05343Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.2431Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.4297Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.5529Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.7Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.8216Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.8393Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hearing physiology0.0006554InformativeDirect
Mammalian Phenotype (MP)abnormal CNS synaptic transmission0.01253InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.01996InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system tract morphology0.02473InformativeInherited
Mammalian Phenotype (MP)abnormal brain white matter morphology0.02592InformativeInherited
Mammalian Phenotype (MP)abnormal fat pad morphology0.04614InformativeInherited
Mammalian Phenotype (MP)abnormal cerebral hemisphere morphology0.06284InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.1147InformativeInherited
Mammalian Phenotype (MP)increased hemolymphoid system tumor incidence0.1195InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.1532InformativeInherited
Mammalian Phenotype (MP)increased malignant tumor incidence0.1997InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.3201InformativeInherited
Mammalian Phenotype (MP)abnormal voluntary movement0.4232InformativeInherited
Mammalian Phenotype (MP)abnormal vasodilation0.0005764Highly InformativeDirect
Mammalian Phenotype (MP)abnormal abdominal fat pad morphology0.0006128Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic beta cell morphology0.0007738Highly InformativeDirect
Mammalian Phenotype (MP)abnormal telencephalon development0.00114Highly InformativeInherited
Mammalian Phenotype (MP)abnormal dorsal telencephalic commissure morphology0.003313Highly InformativeInherited
Mammalian Phenotype (MP)increased leukemia incidence0.005795Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pulmonary alveolus morphology0.0156Highly InformativeInherited
Mammalian Phenotype (MP)abnormal glutamate-mediated receptor currents0.01812Highly InformativeInherited
Mammalian Phenotype (MP)increased sarcoma incidence0.01898Highly InformativeInherited
Mammalian Phenotype (MP)abnormal olfactory bulb morphology0.03072Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lung size0.03689Highly InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory epithelium morphology0.07489Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.0001579Least InformativeDirect
Worm Phenotype (WP)cell death variant0.1074Moderately InformativeInherited
Worm Phenotype (WP)accumulated germline cell corpses0.000103InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo1Least InformativeInherited

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 129 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a PH domain-like domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]