EF-hand modules in multidomain proteins family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All alpha proteins [ 46456] (284)
• Fold: EF Hand-like [ 47472] (4)
• Superfamily: EF-hand [ 47473] (11)
• Family: EF-hand modules in multidomain proteins [ 47547] (8)

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Family statistics

	Genomes (126)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	1,482	4,580	13
Proteins	1,146	3,379	12

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Hydrolases	0	0.01852	--	DIRECT
Enzyme Commission (EC)	Transferases	1	0	--	INHERITED FROM: Diacylglycerol kinase || Phosphotransferases with an alcohol group as accep
Enzyme Commission (EC)	Transferring phosphorous-containing groups	0.06467	0.2728	--	INHERITED FROM: Phosphotransferases with an alcohol group as accep || Diacylglycerol kinase
Enzyme Commission (EC)	Acting on ester bonds	0	0.5107	Least Informative	DIRECT
Enzyme Commission (EC)	Phosphotransferases with an alcohol group as accep	0.0000000664	0.8381	Moderately Informative	DIRECT
Enzyme Commission (EC)	Phosphoric diester hydrolases	0	1.379	Informative	DIRECT
Enzyme Commission (EC)	Diacylglycerol kinase	0	1.963	Highly Informative	DIRECT
Enzyme Commission (EC)	Phosphoinositide phospholipase C	0	1.896	Highly Informative	DIRECT

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	Duchenne muscular dystrophy	0.0000002741	2.513	--	DIRECT
Disease Ontology (DO)	muscle tissue disease	0.002243	1.434	--	INHERITED FROM: Duchenne muscular dystrophy || muscular dystrophy
Disease Ontology (DO)	muscular disease	0.002587	1.399	--	INHERITED FROM: muscular dystrophy || Duchenne muscular dystrophy
Disease Ontology (DO)	disease of anatomical entity	0.2307	0.2414	--	INHERITED FROM: muscular dystrophy || Duchenne muscular dystrophy
Disease Ontology (DO)	musculoskeletal system disease	0.2412	0.89	--	INHERITED FROM: muscular dystrophy || Duchenne muscular dystrophy
Disease Ontology (DO)	myopathy	1	1.559	Informative	INHERITED FROM: Duchenne muscular dystrophy || muscular dystrophy
Disease Ontology (DO)	muscular dystrophy	0.0000636	1.911	Highly Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	dystrophic muscle	0.00001498	2.603	--	DIRECT
Mammalian Phenotype (MP)	skeletal muscle necrosis	0.0000192	2.603	--	DIRECT
Mammalian Phenotype (MP)	kyphosis	0.0007612	2.126	--	DIRECT
Mammalian Phenotype (MP)	abnormal interleukin-2 secretion	0.0287	1.758	--	INHERITED FROM: increased interleukin-2 secretion
Mammalian Phenotype (MP)	abnormal immune system physiology	0.06427	0.6789	--	INHERITED FROM: increased interleukin-2 secretion
Mammalian Phenotype (MP)	muscle phenotype	0.2514	0.8473	--	INHERITED FROM: skeletal muscle necrosis || dystrophic muscle
Mammalian Phenotype (MP)	abnormal nervous system morphology	0.2993	0.5861	--	INHERITED FROM: abnormal somatic motor system morphology
Mammalian Phenotype (MP)	abnormal cytokine secretion	0.3097	1.085	--	INHERITED FROM: increased interleukin-2 secretion
Mammalian Phenotype (MP)	abnormal interleukin secretion	0.3465	1.188	--	INHERITED FROM: increased interleukin-2 secretion
Mammalian Phenotype (MP)	abnormal skeleton morphology	0.4497	0.8323	--	INHERITED FROM: kyphosis
Mammalian Phenotype (MP)	abnormal somatic nervous system morphology	0.4557	0.931	--	INHERITED FROM: abnormal somatic motor system morphology
Mammalian Phenotype (MP)	skeleton phenotype	0.5018	0.8038	--	INHERITED FROM: kyphosis
Mammalian Phenotype (MP)	nervous system phenotype	0.1343	0.4959	Least Informative	INHERITED FROM: abnormal somatic motor system morphology
Mammalian Phenotype (MP)	immune system phenotype	0.2519	0.5462	Least Informative	INHERITED FROM: increased interleukin-2 secretion
Mammalian Phenotype (MP)	abnormal immune serum protein physiology	0.01564	1.001	Moderately Informative	INHERITED FROM: increased interleukin-2 secretion
Mammalian Phenotype (MP)	abnormal axial skeleton morphology	0.1842	1.001	Moderately Informative	INHERITED FROM: kyphosis
Mammalian Phenotype (MP)	abnormal muscle morphology	0.3572	1.112	Moderately Informative	INHERITED FROM: skeletal muscle necrosis || dystrophic muscle
Mammalian Phenotype (MP)	abnormal skeletal muscle morphology	0.03993	1.427	Informative	INHERITED FROM: skeletal muscle necrosis
Mammalian Phenotype (MP)	abnormal vertebral column morphology	0.04617	1.399	Informative	INHERITED FROM: kyphosis
Mammalian Phenotype (MP)	increased interleukin-2 secretion	0.00009073	2.126	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal somatic motor system morphology	0.0005281	2.126	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal spine curvature	0.00241	2.001	Highly Informative	INHERITED FROM: kyphosis

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	muscle system physiology variant	0.00000004976	1.306	--	DIRECT
Worm Phenotype (WP)	striated muscle morphology variant	0.00005254	1.407	--	DIRECT
Worm Phenotype (WP)	muscle system morphology variant	0.00005718	1.407	--	DIRECT
Worm Phenotype (WP)	cell morphology variant	0.001544	0.7558	--	INHERITED FROM: cell type morphology variant || striated muscle morphology variant
Worm Phenotype (WP)	muscle cell morphology variant	0.01246	1.337	--	INHERITED FROM: striated muscle morphology variant
Worm Phenotype (WP)	gene expression variant	0.0129	0.6256	--	INHERITED FROM: protein expression variant
Worm Phenotype (WP)	organ system morphology variant	0.0216	0.7516	--	INHERITED FROM: striated muscle morphology variant || muscle system morphology variant
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.6893	0.1444	--	INHERITED FROM: cell stress response variant || protein expression variant
Worm Phenotype (WP)	organism physiology variant	0.7034	0.1342	--	INHERITED FROM: protein expression variant || cell stress response variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || reproductive system physiology variant || lethal || muscle cell physiology variant || development variant || hermaphrodite sterile || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || fertility variant || muscle system physiology variant || postembryonic development variant || organ system physiology variant || protein expression variant || maternal sterile || cell stress response variant || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	organism environmental stimulus response variant	0.003947	0.6614	Least Informative	INHERITED FROM: cell stress response variant
Worm Phenotype (WP)	cell physiology variant	0.004736	0.5955	Least Informative	INHERITED FROM: cell stress response variant || muscle cell physiology variant
Worm Phenotype (WP)	organism metabolism processing variant	0.02517	0.4899	Least Informative	INHERITED FROM: protein expression variant
Worm Phenotype (WP)	protein expression variant	0.00002804	1.125	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell type morphology variant	0.0003817	0.8878	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell homeostasis metabolism variant	0.0734	1.036	Moderately Informative	INHERITED FROM: cell stress response variant
Worm Phenotype (WP)	organism stress response variant	0.1946	0.9693	Moderately Informative	INHERITED FROM: cell stress response variant
Worm Phenotype (WP)	muscle cell physiology variant	0.00000002631	1.426	Informative	DIRECT
Worm Phenotype (WP)	cell stress response variant	0.00002519	1.538	Informative	DIRECT

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	viable	0	0.6613	Least Informative	DIRECT
Fly Phenotype (FP)	fertile	0	0.8805	Moderately Informative	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	embryonic/larval nervous system	0	0.7171	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.1823	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || nervous system || peripheral nervous system || embryonic/larval nervous system || larva || organ system subdivision || organ system || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: organ system || multicellular structure || organ system subdivision || larva || embryonic/larval nervous system || organism || nervous system || peripheral nervous system
Fly Anatomy (FA)	larva	0	0.3763	Least Informative	DIRECT
Fly Anatomy (FA)	nervous system	0	0.6333	Least Informative	DIRECT
Fly Anatomy (FA)	organ system subdivision	0	0.4301	Least Informative	DIRECT
Fly Anatomy (FA)	peripheral nervous system	0	0.8978	Moderately Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.1857	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1532	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: anatomical system || anatomical group || whole organism

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Diacylglycerol kinase (ATP)	0	2.452	--	DIRECT
Enzyme Commission (EC)	Phosphoinositide phospholipase C	0	2.275	--	DIRECT
Enzyme Commission (EC)	RING-type E3 ubiquitin transferase	0.000000000000001101	1.617	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0.1903	0.7021	--	INHERITED FROM: Phosphotransferases with an alcohol group as acceptor || Diacylglycerol kinase (ATP)
Enzyme Commission (EC)	Hydrolases	0.0000000000001042	0.4043	Least Informative	DIRECT
Enzyme Commission (EC)	Transferases	0.3872	0.3972	Least Informative	INHERITED FROM: Aminoacyltransferases || Diacylglycerol kinase (ATP) || Phosphotransferases with an alcohol group as acceptor || Acyltransferases || RING-type E3 ubiquitin transferase
Enzyme Commission (EC)	Acting on ester bonds	0	0.8756	Moderately Informative	DIRECT
Enzyme Commission (EC)	Phosphotransferases with an alcohol group as acceptor	0.0000006683	1.238	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acyltransferases	0.00001523	1.034	Moderately Informative	DIRECT
Enzyme Commission (EC)	Aminoacyltransferases	0.000000000001569	1.391	Informative	DIRECT
Enzyme Commission (EC)	Phosphoric diester hydrolases	0	1.753	Highly Informative	DIRECT

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