CTD Chemicals (CC): Electrolytes 

Root: CC Hierarchy (CTD chemicals from Comparative Toxicogenomics Database)

Shortest distance to current term (+ for parents, - for children)	CC term [CC ID] <#Children>	#Domains (Superfamily|Family)	#Supra-domain (Single|Duplex|Triple)
+ + 2:	Chemicals [MESH:D] <13>
+ 1:	Inorganic Chemicals [MESH:D007287] <48>	(506|690)	(514|450|213)
0:	Electrolytes [MESH:D004573] <16>	(260|356)	(273|238|117)
- 1:	Ions [MESH:D007477] <1>	(153|203)	(167|135|68)
- 1:	Celsior [MESH:C088453]	(1|1)	(1|0|0)
- 1:	Correctol eyedrops [MESH:C029512]	(0|0)	(0|0|0)
- 1:	Dioralyte [MESH:C040673]	(0|0)	(0|0|0)
- 1:	Golytely [MESH:C033608]	(0|0)	(0|0|0)
- 1:	ORALIT [MESH:C034130]	(0|0)	(0|0|0)
- 1:	PMF-100 solution [MESH:C101026]	(0|0)	(0|0|0)
- 1:	PentaLyte [MESH:C112942]	(0|0)	(0|0|0)
- 1:	Plasmalyte A [MESH:C048013]	(0|0)	(0|0|0)
- 1:	Plasmalyte R [MESH:C048012]	(0|0)	(0|0|0)
- 1:	Polyelectrolytes [MESH:D000071228]	(0|0)	(0|0|0)
- 1:	ProcalAmine [MESH:C052903]	(0|0)	(0|0|0)
- 1:	Ringerfundin [MESH:C555762]	(0|0)	(0|0|0)
- 1:	Servalyte [MESH:C029168]	(0|0)	(0|0|0)
- 1:	amino-acid, glucose, and electrolyte solution [MESH:C545824]	(0|0)	(0|0|0)
- 1:	dextrolyte [MESH:C045217]	(0|0)	(0|0|0)

Superfamily

Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
DNA-glycosylase	0	DIRECT
Crisp domain-like	0	DIRECT
occludin/ELL-like	0	DIRECT
Calcium-dependent phosphotriesterase	0	DIRECT
Serum albumin-like	0	DIRECT
Terpenoid synthases	0	DIRECT
PRC-barrel domain	0	DIRECT
Ribosomal protein L30p/L7e	0	DIRECT
DEK C-terminal domain	0	DIRECT
GYF domain	0	DIRECT
BAG domain	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
Nuclear receptor coactivator interlocking domain	0	DIRECT
Formate/glycerate dehydrogenase catalytic domain-like	0	DIRECT
GINS helical bundle-like	0	DIRECT
HRDC-like	0	DIRECT
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	0	DIRECT
Mediator hinge subcomplex-like	0	DIRECT
SIS domain	0	DIRECT
Di-copper centre-containing domain	0	DIRECT
EB1 dimerisation domain-like	0	DIRECT
CCHHC domain	0	DIRECT
DUSP-like	0	DIRECT
Inosine monophosphate dehydrogenase (IMPDH)	0	DIRECT
beta-lactamase/transpeptidase-like	0	DIRECT
Alpha-L RNA-binding motif	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
LeuD/IlvD-like	0	DIRECT
Protein prenylyltransferase	0	DIRECT
GHMP Kinase, C-terminal domain	0	DIRECT
GroES-like	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
Nucleotide-binding domain	0	DIRECT
Nitric oxide (NO) synthase oxygenase domain	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
Carbohydrate phosphatase	0	DIRECT
Formyltransferase	0	DIRECT
Orange domain-like	0	DIRECT
I/LWEQ domain	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
N-(deoxy)ribosyltransferase-like	0	DIRECT
Phosphoglucomutase, C-terminal domain	0	DIRECT
LCCL domain	0	DIRECT
EPT/RTPC-like	0	DIRECT
Trimeric LpxA-like enzymes	0	DIRECT
Lipoxigenase	0	DIRECT
Glutamine synthetase/guanido kinase	0	DIRECT
MAPEG domain-like	0	DIRECT
AXH domain	0	DIRECT
C-terminal domain of adenylylcyclase associated protein	0	DIRECT
PHM/PNGase F	0	DIRECT
Protein serine/threonine phosphatase 2C, C-terminal domain	0	DIRECT
Nucleoplasmin-like core domain	0	DIRECT
P-domain of calnexin/calreticulin	0	DIRECT
AhpD-like	0	DIRECT
BRK domain-like	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
SMAD MH1 domain	0	DIRECT
ClpS-like	0	DIRECT
ISP domain	0	DIRECT
Hypothetical protein c14orf129, hspc210	0	DIRECT
alpha-ketoacid dehydrogenase kinase, N-terminal domain	0	DIRECT
Uracil-DNA glycosylase-like	0	DIRECT
Rudiment single hybrid motif	0	DIRECT
S13-like H2TH domain	0	DIRECT
Metallothionein	0	DIRECT
Phosphoenolpyruvate/pyruvate domain	0	DIRECT
HMA, heavy metal-associated domain	0	DIRECT
PEBP-like	0	DIRECT
Release factor	0	DIRECT
SRF-like	0	DIRECT
14-3-3 protein	0	DIRECT
Assembly domain of cartilage oligomeric matrix protein	0	DIRECT
TSP type-3 repeat	0	DIRECT
JAB1/MPN domain	0	DIRECT
ITPase-like	0	DIRECT
Chitinase insertion domain	0	DIRECT
FMT C-terminal domain-like	0	DIRECT
Alanine racemase C-terminal domain-like	0	DIRECT
DHS-like NAD/FAD-binding domain	0	DIRECT
tRNA-intron endonuclease catalytic domain-like	0	DIRECT
RmlC-like cupins	0	DIRECT
Isocitrate/Isopropylmalate dehydrogenase-like	0	DIRECT
DNA ligase/mRNA capping enzyme, catalytic domain	0	DIRECT
PLP-binding barrel	0	DIRECT
ATP-dependent DNA ligase DNA-binding domain	0	DIRECT
Ribosomal proteins L15p and L18e	0	DIRECT
Profilin (actin-binding protein)	0	DIRECT
AlbA-like	0	DIRECT
Phosphofructokinase	0	DIRECT
GTF2I-like repeat	0	DIRECT
BSD domain-like	0	DIRECT
Aconitase iron-sulfur domain	0	DIRECT
CAPPD, an extracellular domain of amyloid beta A4 protein	0	DIRECT
Bcl-2 inhibitors of programmed cell death	0	DIRECT
Eferin C-derminal domain-like	0	DIRECT
Microbial and mitochondrial ADK, insert "zinc finger" domain	0	DIRECT
VHP, Villin headpiece domain	0	DIRECT
ACP-like	0	DIRECT
Integrin beta tail domain	0	DIRECT
Subtilisin-like	0	DIRECT
Guanido kinase N-terminal domain	0	DIRECT
LysM domain	0	DIRECT
Proteasome activator	0	DIRECT
Aldolase	0	DIRECT
N-terminal domain of cbl (N-cbl)	0	DIRECT
PurM N-terminal domain-like	0	DIRECT
Endosomal sorting complex assembly domain	0	DIRECT
WGR domain-like	0	DIRECT
Oligoxyloglucan reducing end-specific cellobiohydrolase	0	DIRECT
A heparin-binding domain	0	DIRECT
Fibrinogen coiled-coil and central regions	0	DIRECT
Apolipoprotein A-I	0	DIRECT
RBP11-like subunits of RNA polymerase	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	DIRECT
Proton glutamate symport protein	0	DIRECT
Probable bacterial effector-binding domain	0	DIRECT
p53 tetramerization domain	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
IP3 receptor type 1 binding core, domain 2	0	DIRECT
Amyloid beta a4 protein copper binding domain (domain 2)	0	DIRECT
Caspase-like	0	DIRECT
His-Me finger endonucleases	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
Subdomain of clathrin and coatomer appendage domain	0	DIRECT
RGC domain-like	0	DIRECT
PriA/YqbF domain	0	DIRECT
Methylglyoxal synthase-like	0	DIRECT
Chicken cartilage matrix protein	0	DIRECT
Nucleoporin domain	0	DIRECT
alpha-catenin/vinculin-like	0	DIRECT
Hook domain	0	DIRECT
Ribosomal protein L1	0	DIRECT
Pentapeptide repeat-like	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
PABC (PABP) domain	0	DIRECT
Amine oxidase N-terminal region	0	DIRECT
STAT	0	DIRECT
Amine oxidase catalytic domain	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
3-carboxy-cis,cis-mucoante lactonizing enzyme	0	DIRECT
Restriction endonuclease-like	0	DIRECT
SPOC domain-like	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
Small-conductance potassium channel	0	DIRECT
HIT-like	0	DIRECT
PRTase-like	0	DIRECT
L27 domain	0	DIRECT
C-terminal domain of PLC-beta	0	DIRECT
PAP/Archaeal CCA-adding enzyme, C-terminal domain	0	DIRECT
USP8 N-terminal domain-like	0	DIRECT
Mannose 6-phosphate receptor domain	0	DIRECT
Moesin tail domain	0	DIRECT
Homocysteine S-methyltransferase	0	DIRECT
Activating enzymes of the ubiquitin-like proteins	0	DIRECT
Zinc beta-ribbon	0	DIRECT
Notch domain	0	DIRECT
Ribosomal proteins S24e, L23 and L15e	0	DIRECT
DNA-binding domain	0	DIRECT
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain	0	DIRECT
FAD-linked oxidoreductase	0	DIRECT
Transcription factor STAT-4 N-domain	0	DIRECT
RILP dimerisation region	0	DIRECT
AraD/HMP-PK domain-like	0	DIRECT
Plakin repeat	0	DIRECT
GAT-like domain	0	DIRECT
Somatomedin B domain	0	DIRECT
Ribosomal protein L10-like	0	DIRECT
Roadblock/LC7 domain	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
PurM C-terminal domain-like	0	DIRECT
Translational machinery components	0	DIRECT
NAD(P)-binding Rossmann-fold domains	0.00212	INHERITED FROM: Sulfates
PH domain-like	0.005486	INHERITED FROM: Chromates
Protein kinase-like (PK-like)	0.008506	INHERITED FROM: diallyl disulfide || Hypochlorous Acid || Arsenites || Asbestos || calcium silicate || Silicates || Chlorides || Chromates || Silicic Acid || Nitrates
Integrin domains	0.008676	INHERITED FROM: Sulfides || Aluminum Oxide || Chlorides
Rhodanese/Cell cycle control phosphatase	0.01681	INHERITED FROM: Arsenites || Asbestos, Amphibole || Asbestos, Crocidolite || Chromates
Interleukin 8-like chemokines	0.02277	INHERITED FROM: Asbestos, Serpentine || Fluorides || Asbestos || Magnesium Silicates || Alum Compounds || Hydroxides || Aluminum Hydroxide || zinc chloride || cobalt oxide || sodium bichromate || Chlorides
Leucine zipper domain	0.02447	INHERITED FROM: Hypochlorous Acid || Arsenites || Asbestos || Sulfides || Sulfates || Peroxides || cadmium sulfate || Chlorides || Silicic Acid
Thioredoxin-like	0.02632	INHERITED FROM: 2,2'-dihydroxy-6,6'-dinaphthyldisulfide || Mercuric Chloride || Lipid Peroxides
EGF/Laminin	0.03687	INHERITED FROM: Arsenites || Sulfides || Silicon Dioxide || Vanadates
Class II aaRS and biotin synthetases	0.04155	INHERITED FROM: Sulfates || Copper Sulfate
Kringle-like	0.04211	INHERITED FROM: Sulfides || sodium bisulfide || Aluminum Oxide || Disulfiram
Histone-fold	0.04588	INHERITED FROM: Sulfates || Silicon Dioxide || Copper Sulfate
DEATH domain	0.05295	INHERITED FROM: Fluorides || Magnesium Oxide || tetraarsenic tetrasulfide || Asbestos || Sulfides || zinc sulfide || Arsenic Trioxide || Sodium Fluoride || Silicic Acid
p53-like transcription factors	0.0695	INHERITED FROM: artemisinine || Zinc Oxide || Sodium Fluoride || Cyanides || Asbestos, Crocidolite || Nitroprusside || Zinc Sulfate || pervanadate || Sodium Chloride || arsenite
Bromodomain	0.07	INHERITED FROM: Superoxides
(Phosphotyrosine protein) phosphatases II	0.09252	INHERITED FROM: oxovanadium IV || Vanadates
Alkaline phosphatase-like	0.0933	INHERITED FROM: Vanadates
Nuclear receptor ligand-binding domain	0.09473	INHERITED FROM: Arsenites || Artemisinins
Cyclin-like	0.09703	INHERITED FROM: Lithium Chloride || tetraarsenic tetrasulfide || Sulfides || Peroxides || Nitrates
Ferredoxin reductase-like, C-terminal NADP-linked domain	0.09896	INHERITED FROM: Superoxides || Nitric Oxide || Cyanides || Nitroprusside || Nitrogen Oxides
Riboflavin synthase domain-like	0.09896	INHERITED FROM: Superoxides || Nitric Oxide || Cyanides || Nitroprusside || Nitrogen Oxides
ALDH-like	0.09896	INHERITED FROM: Phosphoramides || Phosphoramide Mustards || Phosphates || perfosfamide
Complement control module/SCR domain	0.1077	INHERITED FROM: Arsenites
GST C-terminal domain-like	0.108	INHERITED FROM: Artemisinins || Lipid Peroxides
Thyroglobulin type-1 domain	0.1308	INHERITED FROM: Arsenites || Phosphoramide Mustards || Arsenates || mercuric bromide || Bromides
PLC-like phosphodiesterases	0.1501	INHERITED FROM: Asbestos
Serpins	0.1677	INHERITED FROM: Arsenites || sodium arsenite
SH2 domain	0.1755	INHERITED FROM: pervanadate
TNF receptor-like	0.1852	INHERITED FROM: Fluorides || Magnesium Oxide || Arsenic Trioxide
Growth factor receptor domain	0.1857	INHERITED FROM: CMF regimen
Putative DNA-binding domain	0.1937	INHERITED FROM: Sulfides
Heme-dependent peroxidases	0.1937	INHERITED FROM: Fluorides || Sodium Fluoride || Nitrogen Dioxide || Nitrogen Oxides
GLA-domain	0.1958	INHERITED FROM: Calcium Chloride
Hemopexin-like domain	0.1964	INHERITED FROM: Aluminum Oxide || dihydroartemisinin
A DNA-binding domain in eukaryotic transcription factors	0.221	INHERITED FROM: Potassium Dichromate || Hypochlorous Acid || Arsenites || Sulfides || Disulfides || zinc chloride
Annexin	0.2231	INHERITED FROM: Bromides
Integrin alpha N-terminal domain	0.2286	INHERITED FROM: Sulfides || Aluminum Oxide
Nucleotidylyl transferase	0.2578	INHERITED FROM: Ifosfamide
Cytochrome P450	0.2731	INHERITED FROM: dipropyl sulfide || Phosphoramides || artemisinine || rabeprazole-thioether || 4-hydroxycyclophosphamide || Celsior || n-propyl disulfide || dechloroethylcyclophosphamide || Phosphates || Ifosfamide
Inhibitor of apoptosis (IAP) repeat	0.2801	INHERITED FROM: diallyl disulfide || Fluorides || Sulfides || allyl sulfide || Nitric Oxide || ajoene || Disulfides || Nitrogen Oxides
Glucocorticoid receptor-like (DNA-binding domain)	0.287	INHERITED FROM: Arsenites || Artemisinins || arsenite
PGBD-like	0.325	INHERITED FROM: allyl sulfide || Vanadates || Aluminum Oxide || Cadmium Chloride || Disulfides || dihydroartemisinin || Artemisinins
FAD/NAD(P)-binding domain	0.3284	INHERITED FROM: cadmium sulfide
Heat shock protein 70kD (HSP70), C-terminal subdomain	0.3292	INHERITED FROM: Phosphoramides || Asbestos || Sulfides || sodium arsenite || Phosphoramide Mustards || Asbestos, Amphibole || Arsenic Trioxide || Silicates || cadmium sulfate || Phosphates || Disulfiram || Silicic Acid || Nitrates
Thiolase-like	0.3292	INHERITED FROM: Potassium Dichromate || Sulfates
Flavoproteins	0.3292	INHERITED FROM: Nitric Oxide || Cyanides || Nitroprusside || Hydrogen Peroxide || Nitrogen Oxides || diallyl trisulfide
Toll/Interleukin receptor TIR domain	0.3337	INHERITED FROM: Sulfides || zinc sulfide
CAD & PB1 domains	0.3422	INHERITED FROM: Fluorides
Actin-like ATPase domain	0.3453	INHERITED FROM: Sulfides || Nitrates
E2F-DP heterodimerization region	0.3726	INHERITED FROM: Arsenic Trioxide || Silver Nitrate || Nitrates
HSP40/DnaJ peptide-binding domain	0.3726	INHERITED FROM: Disulfiram
Carbonic anhydrase	0.3758	INHERITED FROM: Chlorates || Carbonates || Bromates || Vanadates || chloric acid || Iodates || sodium metasilicate
Metalloproteases ("zincins"), catalytic domain	0.3971	INHERITED FROM: Aluminum Oxide
FnI-like domain	0.4177	INHERITED FROM: mercuric bromide || Bromides
Ferritin-like	0.4771	INHERITED FROM: sodium arsenite || diallyl trisulfide
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0.4771	INHERITED FROM: Disulfides || Arsenates || Mercuric Chloride || Phosphates || Disulfiram
4-helical cytokines	0.4796	INHERITED FROM: Nitric Oxide || sodium bisulfide || Alum Compounds || Hydroxides || Nitroprusside || mineral trioxide aggregate || Nitrogen Oxides || Mercuric Chloride || Phosphates || FEC protocol || Aluminum Chloride || sodium bichromate || Chlorides || Nitrites || Nitrates
PAP/OAS1 substrate-binding domain	0.4936	INHERITED FROM: Asbestos, Serpentine || Magnesium Silicates
HSP20-like chaperones	0.4939	INHERITED FROM: Disulfides || Disulfiram
Nucleic acid-binding proteins	0.4967	INHERITED FROM: Peroxides
Ribosomal protein S5 domain 2-like	0.5034	INHERITED FROM: Cadmium Chloride
Calponin-homology domain, CH-domain	0.5372	INHERITED FROM: dihydroartemisinin
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0.5384	INHERITED FROM: Ifosfamide
ABC transporter transmembrane region	0.547	INHERITED FROM: diallyl disulfide || Fluorides || Sulfides || allyl sulfide
SET domain	0.5533	INHERITED FROM: Nitric Oxide
LDH C-terminal domain-like	0.5624	INHERITED FROM: dihydroartemisinin || Artemisinins
Cation efflux protein transmembrane domain-like	0.634	INHERITED FROM: zinc chloride
TNF-like	0.6365	INHERITED FROM: Fluorides
Cadherin-like	0.6397	INHERITED FROM: Asbestos, Serpentine || Magnesium Silicates || arsenite
Kazal-type serine protease inhibitors	0.6522	INHERITED FROM: Arsenites
"Winged helix" DNA-binding domain	0.6549	INHERITED FROM: Silver Nitrate || Nitrates
NAD(P)-linked oxidoreductase	0.6855	INHERITED FROM: Phosphoramide Mustards || cadmium sulfate || Disulfides || Disulfiram
Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain	0.6857	INHERITED FROM: Asbestos, Amphibole || Asbestos, Crocidolite
Cytokine	0.7125	INHERITED FROM: zinc sulfide || Alum Compounds || Hydroxides || Sodium Chloride
Frizzled cysteine-rich domain	0.7564	INHERITED FROM: Lithium Chloride || Arsenates
HLH, helix-loop-helix DNA-binding domain	0.7744	INHERITED FROM: arsenite
Clavaminate synthase-like	0.8153	INHERITED FROM: Nitric Oxide || Nitrogen Oxides
Homeodomain-like	0.8817	INHERITED FROM: Arsenites || arsenite
Aquaporin-like	0.9454	INHERITED FROM: Hydroxides || Mercuric Chloride || Water
Trypsin-like serine proteases	1	INHERITED FROM: Calcium Chloride
B-box zinc-binding domain	1	INHERITED FROM: Sodium Hydroxide
Cystine-knot cytokines	1	INHERITED FROM: chromous chloride || Aluminum Oxide || Sodium Chloride
L domain-like	1	INHERITED FROM: CMF regimen
RING/U-box	1	INHERITED FROM: Sodium Hydroxide
Family A G protein-coupled receptor-like	1	INHERITED FROM: Asbestos, Crocidolite
Immunoglobulin	1	INHERITED FROM: Aluminum Hydroxide

Family

Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
DNase I-like	0	DIRECT
JAB1/MPN domain	0	DIRECT
Sm motif of small nuclear ribonucleoproteins, SNRNP	0	DIRECT
Roadblock/LC7 domain	0	DIRECT
Protein-L-isoaspartyl O-methyltransferase	0	DIRECT
4HBT-like	0	DIRECT
Autophagin-like	0	DIRECT
Nuclear receptor coactivator interlocking domain	0	DIRECT
Pentapeptide repeats	0	DIRECT
Microbial and mitochondrial ADK, insert "zinc finger" domain	0	DIRECT
Sir2 family of transcriptional regulators	0	DIRECT
alpha-ketoacid dehydrogenase kinase, N-terminal domain	0	DIRECT
C5 cytosine-specific DNA methylase, DCM	0	DIRECT
Ribonuclease PH domain 1-like	0	DIRECT
Laminin-type module	0	DIRECT
Formate/glycerate dehydrogenases, substrate-binding domain	0	DIRECT
Profilin (actin-binding protein)	0	DIRECT
p53 tetramerization domain	0	DIRECT
Proprotein convertase P-domain	0	DIRECT
Release factor	0	DIRECT
Phosphoribosylpyrophosphate synthetase-like	0	DIRECT
Amine oxidase N-terminal region	0	DIRECT
TRASH domain	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
Caspase catalytic domain	0	DIRECT
Alcohol dehydrogenase-like, N-terminal domain	0	DIRECT
Proton glutamate symport protein	0	DIRECT
Alkaline phosphatase	0	DIRECT
Ribosomal protein L1	0	DIRECT
A20-like zinc finger	0	DIRECT
Deoxycytidylate deaminase-like	0	DIRECT
Ribosomal protein L3	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
Class I aldolase	0	DIRECT
IP3 receptor type 1 binding core, domain 2	0	DIRECT
Hook domain	0	DIRECT
2'-5'-oligoadenylate synthetase 1, OAS1, second domain	0	DIRECT
AXH domain	0	DIRECT
NADPH-cytochrome p450 reductase FAD-binding domain-like	0	DIRECT
HEAT repeat	0	DIRECT
Neurolysin-like	0	DIRECT
Serine carboxypeptidase-like	0	DIRECT
Mannose 6-phosphate receptor domain	0	DIRECT
Group II chaperonin (CCT, TRIC), intermediate domain	0	DIRECT
Heat shock protein 90, HSP90, N-terminal domain	0	DIRECT
2Fe-2S ferredoxin domains from multidomain proteins	0	DIRECT
LON domain-like	0	DIRECT
Hairy Orange domain	0	DIRECT
Inositol monophosphatase/fructose-1,6-bisphosphatase-like	0	DIRECT
Inosine monophosphate dehydrogenase (IMPDH)	0	DIRECT
Ferritin	0	DIRECT
Assembly domain of cartilage oligomeric matrix protein	0	DIRECT
DNA ligase	0	DIRECT
Phosphoglucomutase, C-terminal domain	0	DIRECT
Ribonuclease H	0	DIRECT
BC C-terminal domain-like	0	DIRECT
Glycerol kinase	0	DIRECT
Subtilases	0	DIRECT
Methyl-CpG-binding domain, MBD	0	DIRECT
DEATH effector domain, DED	0	DIRECT
DNA gyrase/MutL, N-terminal domain	0	DIRECT
D-aminoacid oxidase-like	0	DIRECT
Transcriptional factor domain	0	DIRECT
tRNA-intron endonuclease catalytic domain-like	0	DIRECT
MAPEG domain	0	DIRECT
S-adenosylhomocystein hydrolase	0	DIRECT
Lesion bypass DNA polymerase (Y-family), catalytic domain	0	DIRECT
Phosphofructokinase	0	DIRECT
alpha-catenin/vinculin	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
NagB-like	0	DIRECT
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain	0	DIRECT
Arginase-like amidino hydrolases	0	DIRECT
PAS domain of steroid receptor coactivator 1A, NCo-A1	0	DIRECT
Oligoxyloglucan reducing end-specific cellobiohydrolase	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
Peptidylglycine alpha-hydroxylating monooxygenase, PHM	0	DIRECT
Linker histone H1/H5	0	DIRECT
P-domain of calnexin/calreticulin	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
E2F dimerization segment	0	DIRECT
2'-5'-oligoadenylate synthetase 1, OAS1, N-terminal domain	0	DIRECT
GTF2I-like repeat	0	DIRECT
DNA polymerase III clamp loader subunits, C-terminal domain	0	DIRECT
STAT	0	DIRECT
TatD Mg-dependent DNase-like	0	DIRECT
Dimeric isocitrate & isopropylmalate dehydrogenases	0	DIRECT
Metallothionein	0	DIRECT
DEK C-terminal domain	0	DIRECT
Platelet-derived growth factor-like	0	DIRECT
SMAD MH1 domain	0	DIRECT
a tRNA synthase domain	0	DIRECT
Fibrinogen coiled-coil and central regions	0	DIRECT
Selenoprotein W-related	0	DIRECT
DEATH domain, DD	0	DIRECT
Amyloid beta a4 protein copper binding domain (domain 2)	0	DIRECT
Alpha-adaptin ear subdomain-like	0	DIRECT
Proteasome activator	0	DIRECT
Phosphatidylethanolamine binding protein	0	DIRECT
SelR domain	0	DIRECT
Prohormone convertase 1 pro-domain	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
alpha-ketoacid dehydrogenase kinase, C-terminal domain	0	DIRECT
HMGL-like	0	DIRECT
EB1 dimerisation domain-like	0	DIRECT
ATP-dependent DNA ligase catalytic domain	0	DIRECT
Crisp domain	0	DIRECT
Small-conductance potassium channel	0	DIRECT
CCHHC domain	0	DIRECT
PABC (PABP) domain	0	DIRECT
14-3-3 protein	0	DIRECT
alpha-mannosidase	0	DIRECT
Starch-binding domain	0	DIRECT
DUSP, domain in ubiquitin-specific proteases	0	DIRECT
HMA, heavy metal-associated domain	0	DIRECT
Integrin beta tail domain	0	DIRECT
Leukotriene A4 hydrolase C-terminal domain	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
RNA editing terminal uridyl transferase 2, RET2, domain 2	0	DIRECT
Transcription factor STAT-4 N-domain	0	DIRECT
Bcl-2 inhibitors of programmed cell death	0	DIRECT
BC ATP-binding domain-like	0	DIRECT
LysM domain	0	DIRECT
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain	0	DIRECT
SPOC domain	0	DIRECT
p53 DNA-binding domain-like	0	DIRECT
NIPSNAP	0	DIRECT
Occludin/ELL domain	0	DIRECT
RhoGDI-like	0	DIRECT
Clathrin heavy-chain linker domain	0	DIRECT
Apolipoprotein A-I	0	DIRECT
Moesin tail domain	0	DIRECT
(Glycosyl)asparaginase	0	DIRECT
Chicken cartilage matrix protein	0	DIRECT
Cysteine rich domain	0	DIRECT
Guanido kinase N-terminal domain	0	DIRECT
RILP dimerisation region	0	DIRECT
Transferrin	0	DIRECT
MIF4G domain-like	0	DIRECT
L27 domain	0	DIRECT
Arrestin/Vps26-like	0	DIRECT
Chitinase insertion domain	0	DIRECT
Mammalian PLC	0	DIRECT
DNA/RNA non-specific endonuclease	0	DIRECT
Short-chain cytokines	0	DIRECT
HIT (HINT, histidine triad) family of protein kinase-interacting proteins	0	DIRECT
Plakin repeat	0	DIRECT
NagD-like	0	DIRECT
Adenylyltransferase	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
AraD-like aldolase/epimerase	0	DIRECT
Guanido kinase catalytic domain	0	DIRECT
BRK domain-like	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
NADPH-cytochrome p450 reductase-like	0	DIRECT
Anticodon-binding domain	0	DIRECT
GAT domain	0	DIRECT
Eukaryotic ODC-like	0	DIRECT
Poly(A) polymerase, PAP, N-terminal domain	0	DIRECT
Somatomedin B domain	0	DIRECT
RIKEN cDNA 2310057j16 protein (KIAA1543)	0	DIRECT
B56-like	0	DIRECT
Homocysteine S-methyltransferase	0	DIRECT
Cystathionine synthase-like	0	DIRECT
Class I glutamine amidotransferases (GAT)	0	DIRECT
Notch domain	0	DIRECT
PUA domain	0	DIRECT
Protein serine/threonine phosphatase 2C, C-terminal domain	0	DIRECT
Nuclear movement domain	0	DIRECT
LCCL domain	0	DIRECT
COMT-like	0	DIRECT
Type II chitinase	0	DIRECT
Retinoblastoma tumor suppressor domains	0	DIRECT
Serum paraoxonase/arylesterase 1, PON1	0	DIRECT
PurM C-terminal domain-like	0	DIRECT
Alcohol dehydrogenase-like, C-terminal domain	0	DIRECT
Serum albumin-like	0	DIRECT
VHP, Villin headpiece domain	0	DIRECT
Ubiquitin activating enzymes (UBA)	0	DIRECT
Kringle modules	0	DIRECT
Rel/Dorsal transcription factors, DNA-binding domain	0	DIRECT
Animal lipoxigenases	0	DIRECT
Phosphoribulokinase/pantothenate kinase	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
VHS domain	0	DIRECT
Oligosaccharide phosphorylase	0	DIRECT
Long-chain cytokines	0	DIRECT
Alanine racemase-like, N-terminal domain	0	DIRECT
UBA domain	0	DIRECT
PurM N-terminal domain-like	0	DIRECT
alpha-mannosidase, C-terminal domain	0	DIRECT
Poly(ADP-ribose) polymerase, C-terminal domain	0	DIRECT
Nitric oxide (NO) synthase oxygenase domain	0	DIRECT
Hexokinase	0	DIRECT
Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	0	DIRECT
Poly(A) polymerase, PAP, middle domain	0	DIRECT
Pseudouridine synthase II TruB	0	DIRECT
Isoprenyl diphosphate synthases	0	DIRECT
Branched-chain alpha-keto acid dehydrogenase Pyr module	0	DIRECT
Calnexin/calreticulin	0	DIRECT
USP8 N-terminal domain-like	0	DIRECT
GHMP Kinase, N-terminal domain	0	DIRECT
Formate/glycerate dehydrogenases, NAD-domain	0	DIRECT
XPF/Rad1/Mus81 nuclease	0	DIRECT
PCI domain (PINT motif)	0	DIRECT
Cytidylyltransferase	0	DIRECT
N-terminal domain of cbl (N-cbl)	0	DIRECT
N-type ATP pyrophosphatases	0	DIRECT
Glucose 6-phosphate dehydrogenase-like	0	DIRECT
L-aspartase/fumarase	0	DIRECT
beta-glycanases	0	DIRECT
Variant SAM domain	0	DIRECT
Hsp90 middle domain	0	DIRECT
Phosphoribosyltransferases (PRTases)	0	DIRECT
Nucleoplasmin-like core domain	0	DIRECT
Pseudouridine synthase I TruA	0	DIRECT
Neurotrophin	0	DIRECT
BSD domain	0	DIRECT
WGR domain	0	DIRECT
Ephrin ectodomain	0	DIRECT
LeuD-like	0	DIRECT
I/LWEQ domain	0	DIRECT
UBX domain	0	DIRECT
alpha-mannosidase, domain 2	0	DIRECT
Thiolase-related	0	DIRECT
Arfaptin, Rac-binding fragment	0	DIRECT
Amine oxidase catalytic domain	0	DIRECT
Aconitase iron-sulfur domain	0	DIRECT
SRF-like	0	DIRECT
TSP type-3 repeat	0	DIRECT
Ribosomal proteins L15p and L18e	0	DIRECT
Integrin beta EGF-like domains	0	DIRECT
Ribosomal protein L18 and S11	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
BC N-terminal domain-like	0	DIRECT
DNA polymerase I	0	DIRECT
Clathrin adaptor appendage, alpha and beta chain-specific domain	0	DIRECT
Poly(A) polymerase, PAP, C-terminal domain	0	DIRECT
Exostosin	0	DIRECT
Protein prenylyltransferase	0	DIRECT
A heparin-binding domain	0	DIRECT
Ubiquitin carboxyl-terminal hydrolase UCH-L	0	DIRECT
Filamin repeat (rod domain)	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
Choline/Carnitine O-acyltransferase	0	DIRECT
SMAD domain	0	DIRECT
HD domain	0	DIRECT
GYF domain	0	DIRECT
STAT DNA-binding domain	0	DIRECT
Eferin C-derminal domain-like	0	DIRECT
C-terminal domain of PLC-beta	0	DIRECT
DNA ligase/mRNA capping enzyme postcatalytic domain	0	DIRECT
CAPPD, an extracellular domain of amyloid beta A4 protein	0	DIRECT
UDP-glucose pyrophosphorylase	0	DIRECT
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain	0	DIRECT
RuBisCo LSMT catalytic domain	0	DIRECT
BAG domain	0	DIRECT
DNA gyrase/MutL, second domain	0	DIRECT
TNF receptor-like	0	DIRECT
C-terminal domain of adenylylcyclase associated protein	0	DIRECT
RGC domain	0	DIRECT
Formyltransferase	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
Leukotriene A4 hydrolase N-terminal domain	0	DIRECT
RBP11/RpoL	0	DIRECT
Cell cycle control phosphatase, catalytic domain	0	DIRECT
Carbamilase	0	DIRECT
STAR domain	0	DIRECT
p25-alpha	0	DIRECT
Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain	0	DIRECT
DNA replication initiator (cdc21/cdc54) N-terminal domain	0	DIRECT
Thrombospondin C-terminal domain	0	DIRECT
Integrin domains	0.009024	INHERITED FROM: Sulfides || Aluminum Oxide || Chlorides
Protein kinases, catalytic subunit	0.01341	INHERITED FROM: diallyl disulfide || Hypochlorous Acid || Arsenites || Asbestos || calcium silicate || Silicates || Chromates
Nucleosome core histones	0.02156	INHERITED FROM: Sulfates || Silicon Dioxide || Copper Sulfate
Interleukin 8-like chemokines	0.0257	INHERITED FROM: Asbestos, Serpentine || Fluorides || Asbestos || Magnesium Silicates || Alum Compounds || Hydroxides || Aluminum Hydroxide || zinc chloride || cobalt oxide || sodium bichromate || Chlorides
Leucine zipper domain	0.0272	INHERITED FROM: Hypochlorous Acid || Arsenites || Asbestos || Sulfides || Sulfates || Peroxides || cadmium sulfate || Chlorides || Silicic Acid
Pleckstrin-homology domain (PH domain)	0.0301	INHERITED FROM: Chromates
Glutathione S-transferase (GST), C-terminal domain	0.03157	INHERITED FROM: Artemisinins || Lipid Peroxides
Integrin alpha N-terminal domain	0.03236	INHERITED FROM: Sulfides || Aluminum Oxide
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain	0.06454	INHERITED FROM: Sulfates || Copper Sulfate
Higher-molecular-weight phosphotyrosine protein phosphatases	0.07203	INHERITED FROM: oxovanadium IV || Vanadates
Glutathione S-transferase (GST), N-terminal domain	0.07352	INHERITED FROM: Artemisinins || Lipid Peroxides
Bromodomain	0.07457	INHERITED FROM: Superoxides
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain	0.08807	INHERITED FROM: Asbestos, Crocidolite
ALDH-like	0.09801	INHERITED FROM: Phosphoramides || Phosphoramide Mustards || Phosphates || perfosfamide
Caspase recruitment domain, CARD	0.09801	INHERITED FROM: Sulfides
Nuclear receptor ligand-binding domain	0.1016	INHERITED FROM: Arsenites || Artemisinins
Laminin G-like module	0.1128	INHERITED FROM: Arsenites
Nuclear receptor	0.1221	INHERITED FROM: Artemisinins
Thyroglobulin type-1 domain	0.1285	INHERITED FROM: Arsenites || Arsenates || mercuric bromide || Bromides
Glutathione peroxidase-like	0.1634	INHERITED FROM: Hydrogen Peroxide || Quartz
Dual specificity phosphatase-like	0.1735	INHERITED FROM: Asbestos, Crocidolite
Myeloperoxidase-like	0.188	INHERITED FROM: Fluorides || Sodium Fluoride || Nitrogen Dioxide || Nitrogen Oxides
S100 proteins	0.1897	INHERITED FROM: Calcium Chloride
Arylsulfatase	0.1897	INHERITED FROM: Vanadates
GLA-domain	0.191	INHERITED FROM: Calcium Chloride
Serpins	0.1961	INHERITED FROM: Arsenites || sodium arsenite
Hemopexin-like domain	0.1994	INHERITED FROM: Aluminum Oxide || dihydroartemisinin
SH2 domain	0.2016	INHERITED FROM: pervanadate
Annexin	0.2179	INHERITED FROM: Bromides
A DNA-binding domain in eukaryotic transcription factors	0.2202	INHERITED FROM: Potassium Dichromate || Hypochlorous Acid || Arsenites || Sulfides || Disulfides || zinc chloride
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain	0.2713	INHERITED FROM: Sulfides || Disulfiram
Erythroid transcription factor GATA-1	0.2713	INHERITED FROM: mercuric bromide || Bromides
Inhibitor of apoptosis (IAP) repeat	0.2713	INHERITED FROM: diallyl disulfide || Fluorides || Sulfides || allyl sulfide || Nitric Oxide || ajoene || Disulfides || Nitrogen Oxides
Cell cycle transcription factor e2f-dp	0.2817	INHERITED FROM: Arsenic Trioxide || Silver Nitrate || Nitrates
Cyclin	0.2848	INHERITED FROM: Lithium Chloride || tetraarsenic tetrasulfide
Cytochrome P450	0.3074	INHERITED FROM: dipropyl sulfide || Phosphoramides || artemisinine || rabeprazole-thioether || 4-hydroxycyclophosphamide || Celsior || n-propyl disulfide || dechloroethylcyclophosphamide || Phosphates || Ifosfamide
Heat shock protein 70kD (HSP70), C-terminal subdomain	0.3196	INHERITED FROM: Phosphoramides || Asbestos || Sulfides || sodium arsenite || Phosphoramide Mustards || Asbestos, Amphibole || Arsenic Trioxide || Silicates || cadmium sulfate || Phosphates || Disulfiram || Silicic Acid || Nitrates
Interleukin-1 (IL-1)	0.3196	INHERITED FROM: Asbestos, Serpentine || Magnesium Silicates || zinc sulfide || Alum Compounds || Hydroxides || zinc chloride
MMP N-terminal domain	0.3249	INHERITED FROM: allyl sulfide || Vanadates || Aluminum Oxide || Cadmium Chloride || Disulfides || dihydroartemisinin || Artemisinins
Growth factor receptor domain	0.3458	INHERITED FROM: CMF regimen || Chlorides
HSP40/DnaJ peptide-binding domain	0.362	INHERITED FROM: Disulfiram
C2 set domains	0.362	INHERITED FROM: Hydroxides
Carbonic anhydrase	0.3726	INHERITED FROM: Chlorates || Carbonates || Bromates || Vanadates || chloric acid || Iodates || sodium metasilicate
Matrix metalloproteases, catalytic domain	0.3802	INHERITED FROM: allyl sulfide || Vanadates || Aluminum Oxide || Disulfides || dihydroartemisinin
Fibronectin type II module	0.3821	INHERITED FROM: Sulfides || sodium bisulfide || Aluminum Oxide || Disulfiram
Toll/Interleukin receptor TIR domain	0.3931	INHERITED FROM: Sulfides || zinc sulfide
Tudor domain	0.424	INHERITED FROM: Nitric Oxide
ABC transporter ATPase domain-like	0.4242	INHERITED FROM: diallyl disulfide || Sulfides
Integrin A (or I) domain	0.4299	INHERITED FROM: Chlorides
Papain-like	0.446	INHERITED FROM: sodium bichromate
ABC transporter transmembrane region	0.4563	INHERITED FROM: diallyl disulfide || Fluorides || Phosphoramides || Sulfides || allyl sulfide
Ovomucoid domain III-like	0.4608	INHERITED FROM: Arsenites
L domain	0.4639	INHERITED FROM: Phosphoramides || sodium arsenite || Phosphates || CMF regimen
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0.4639	INHERITED FROM: Disulfides || Arsenates || Mercuric Chloride || Phosphates || Disulfiram
Cytochrome p450 reductase N-terminal domain-like	0.4639	INHERITED FROM: Nitric Oxide || Cyanides || Nitroprusside || Nitrogen Oxides
Ephrin receptor ligand binding domain	0.4879	INHERITED FROM: Arsenates
Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain	0.4924	INHERITED FROM: potassium chromate(VI)
Formin homology 2 domain (FH2 domain)	0.5005	INHERITED FROM: potassium chromate(VI)
Netrin-like domain (NTR/C345C module)	0.5233	INHERITED FROM: Arsenic Trioxide
Link domain	0.5299	INHERITED FROM: mercuric bromide || Bromides
FAD/NAD-linked reductases, N-terminal and central domains	0.5299	INHERITED FROM: Arsenates || Mercuric Chloride
LDH N-terminal domain-like	0.5535	INHERITED FROM: dihydroartemisinin || Artemisinins
Lactate & malate dehydrogenases, C-terminal domain	0.5535	INHERITED FROM: dihydroartemisinin || Artemisinins
Class I aminoacyl-tRNA synthetases (RS), catalytic domain	0.5626	INHERITED FROM: Ifosfamide
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0.576	INHERITED FROM: Ifosfamide
TNF-like	0.5862	INHERITED FROM: Fluorides
CAD domain	0.5918	INHERITED FROM: Fluorides
PDI-like	0.605	INHERITED FROM: tetraarsenic tetrasulfide
Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain	0.668	INHERITED FROM: Asbestos, Amphibole || Asbestos, Crocidolite
Enolase	0.668	INHERITED FROM: Cadmium Chloride
Cation efflux protein transmembrane domain-like	0.6747	INHERITED FROM: zinc chloride
Aldo-keto reductases (NADP)	0.6804	INHERITED FROM: cadmium sulfate || Disulfides || Disulfiram
Cadherin	0.7414	INHERITED FROM: Asbestos, Serpentine || Magnesium Silicates || arsenite
Actin/HSP70	0.7456	INHERITED FROM: Sulfides || cadmium sulfate || Quartz
Frizzled cysteine-rich domain	0.7552	INHERITED FROM: Lithium Chloride || Arsenates
HLH, helix-loop-helix DNA-binding domain	0.8147	INHERITED FROM: arsenite
Aquaporin-like	0.9441	INHERITED FROM: Hydroxides || Mercuric Chloride || Water
Transforming growth factor (TGF)-beta	0.9629	INHERITED FROM: chromous chloride || Aluminum Oxide
B-box zinc-binding domain	1	INHERITED FROM: Sodium Hydroxide
Homeodomain	1	INHERITED FROM: Arsenites || arsenite
Eukaryotic proteases	1	INHERITED FROM: Calcium Chloride
Forkhead DNA-binding domain	1	INHERITED FROM: arsenite
V set domains (antibody variable domain-like)	1	INHERITED FROM: Hydroxides || Aluminum Hydroxide

Supra-domain (Single|Duplex|Triple)

Supra-domain (Single)

Highlighted in gray are those with FDR>0.001

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Notch domain	0	DIRECT
Zinc beta-ribbon	0	DIRECT
Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
Hook domain	0	DIRECT
Nucleoporin domain	0	DIRECT
Plakin repeat	0	DIRECT
N-terminal domain of cbl (N-cbl)	0	DIRECT
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	DIRECT
SMAD MH1 domain	0	DIRECT
Homocysteine S-methyltransferase	0	DIRECT
PLP-binding barrel	0	DIRECT
Phosphoglucomutase, first 3 domains	0	DIRECT
RBP11-like subunits of RNA polymerase	0	DIRECT
ITPase-like	0	DIRECT
Amyloid beta a4 protein copper binding domain (domain 2)	0	DIRECT
Formate/glycerate dehydrogenase catalytic domain-like	0	DIRECT
Release factor	0	DIRECT
GINS helical bundle-like	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
CCHHC domain	0	DIRECT
Rudiment single hybrid motif	0	DIRECT
alpha-ketoacid dehydrogenase kinase, N-terminal domain	0	DIRECT
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain	0	DIRECT
BRK domain-like	0	DIRECT
Ribosomal proteins S24e, L23 and L15e	0	DIRECT
Protein prenylyltransferase	0	DIRECT
Mediator hinge subcomplex-like	0	DIRECT
Orange domain-like	0	DIRECT
Lipoxigenase	0	DIRECT
Methylglyoxal synthase-like	0	DIRECT
Assembly domain of cartilage oligomeric matrix protein	0	DIRECT
DNA-glycosylase	0	DIRECT
ISP domain	0	DIRECT
Somatomedin B domain	0	DIRECT
SRF-like	0	DIRECT
Apolipoprotein A-I	0	DIRECT
HMA, heavy metal-associated domain	0	DIRECT
Di-copper centre-containing domain	0	DIRECT
Small-conductance potassium channel	0	DIRECT
GHMP Kinase, C-terminal domain	0	DIRECT
PurM N-terminal domain-like	0	DIRECT
Formyltransferase	0	DIRECT
Probable bacterial effector-binding domain	0	DIRECT
Caspase-like	0	DIRECT
GroES-like	0	DIRECT
STAT	0	DIRECT
DEK C-terminal domain	0	DIRECT
Subdomain of clathrin and coatomer appendage domain	0	DIRECT
PRC-barrel domain	0	DIRECT
C-terminal domain of adenylylcyclase associated protein	0	DIRECT
Phosphofructokinase	0	DIRECT
Integrin beta tail domain	0	DIRECT
FAD-linked oxidoreductase	0	DIRECT
PurM C-terminal domain-like	0	DIRECT
GTF2I-like repeat	0	DIRECT
Oligoxyloglucan reducing end-specific cellobiohydrolase	0	DIRECT
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase	0	DIRECT
Ribosomal protein L10-like	0	DIRECT
Amine oxidase N-terminal region	0	DIRECT
Transcription factor STAT-4 N-domain	0	DIRECT
Ribosomal protein L1	0	DIRECT
Moesin tail domain	0	DIRECT
C-terminal domain of PLC-beta	0	DIRECT
PRTase-like	0	DIRECT
ATP-dependent DNA ligase DNA-binding domain	0	DIRECT
BAG domain	0	DIRECT
Isocitrate/Isopropylmalate dehydrogenase-like	0	DIRECT
DNA-binding domain	0	DIRECT
Crisp domain-like	0	DIRECT
Cu,Zn superoxide dismutase-like	0	DIRECT
SPOC domain-like	0	DIRECT
LCCL domain	0	DIRECT
JAB1/MPN domain	0	DIRECT
DHS-like NAD/FAD-binding domain	0	DIRECT
AhpD-like	0	DIRECT
Cdc48 domain 2-like	0	DIRECT
Aldolase	0	DIRECT
HRDC-like	0	DIRECT
LeuD/IlvD-like	0	DIRECT
DUSP-like	0	DIRECT
p53 tetramerization domain	0	DIRECT
S13-like H2TH domain	0	DIRECT
FAD-dependent thiol oxidase	0	DIRECT
EPT/RTPC-like	0	DIRECT
Nucleotide-binding domain	0	DIRECT
Chitinase insertion domain	0	DIRECT
EB1 dimerisation domain-like	0	DIRECT
Activating enzymes of the ubiquitin-like proteins	0	DIRECT
PHM/PNGase F	0	DIRECT
SIS domain	0	DIRECT
14-3-3 protein	0	DIRECT
I/LWEQ domain	0	DIRECT
PAP/Archaeal CCA-adding enzyme, C-terminal domain	0	DIRECT
Succinyl-CoA synthetase domains	0	DIRECT
GYF domain	0	DIRECT
PABC (PABP) domain	0	DIRECT
Alanine racemase C-terminal domain-like	0	DIRECT
Eferin C-derminal domain-like	0	DIRECT
F1F0 ATP synthase subunit C	0	DIRECT
Endosomal sorting complex assembly domain	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
LysM domain	0	DIRECT
C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
tRNA-intron endonuclease catalytic domain-like	0	DIRECT
VHP, Villin headpiece domain	0	DIRECT
Profilin (actin-binding protein)	0	DIRECT
Inosine monophosphate dehydrogenase (IMPDH)	0	DIRECT
Proteasome activator	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
Bcl-2 inhibitors of programmed cell death	0	DIRECT
CAPPD, an extracellular domain of amyloid beta A4 protein	0	DIRECT
Proton glutamate symport protein	0	DIRECT
RGC domain-like	0	DIRECT
Restriction endonuclease-like	0	DIRECT
Ribonuclease PH domain 2-like	0	DIRECT
P-domain of calnexin/calreticulin	0	DIRECT
WGR domain-like	0	DIRECT
Fibrinogen coiled-coil and central regions	0	DIRECT
Roadblock/LC7 domain	0	DIRECT
Serum albumin-like	0	DIRECT
Subtilisin-like	0	DIRECT
Uracil-DNA glycosylase-like	0	DIRECT
Nuclear receptor coactivator interlocking domain	0	DIRECT
Phosphoenolpyruvate/pyruvate domain	0	DIRECT
alpha-catenin/vinculin-like	0	DIRECT
Guanido kinase N-terminal domain	0	DIRECT
beta-lactamase/transpeptidase-like	0	DIRECT
Nitric oxide (NO) synthase oxygenase domain	0	DIRECT
Translational machinery components	0	DIRECT
AlbA-like	0	DIRECT
occludin/ELL-like	0	DIRECT
RmlC-like cupins	0	DIRECT
Pentapeptide repeat-like	0	DIRECT
Aconitase iron-sulfur domain	0	DIRECT
Protein serine/threonine phosphatase 2C, C-terminal domain	0	DIRECT
USP8 N-terminal domain-like	0	DIRECT
RILP dimerisation region	0	DIRECT
FMT C-terminal domain-like	0	DIRECT
Ribosomal proteins L15p and L18e	0	DIRECT
Domain of poly(ADP-ribose) polymerase	0	DIRECT
Carbohydrate phosphatase	0	DIRECT
Microbial and mitochondrial ADK, insert "zinc finger" domain	0	DIRECT
GAT-like domain	0	DIRECT
Mannose 6-phosphate receptor domain	0	DIRECT
ACP-like	0	DIRECT
Ribosomal protein L30p/L7e	0	DIRECT
DNA ligase/mRNA capping enzyme, catalytic domain	0	DIRECT
AXH domain	0	DIRECT
BSD domain-like	0	DIRECT
MAPEG domain-like	0	DIRECT
HIT-like	0	DIRECT
Amine oxidase catalytic domain	0	DIRECT
Glutamine synthetase/guanido kinase	0	DIRECT
N-(deoxy)ribosyltransferase-like	0	DIRECT
Calcium-dependent phosphotriesterase	0	DIRECT
Hypothetical protein c14orf129, hspc210	0	DIRECT
Nucleoplasmin-like core domain	0	DIRECT
Alpha-L RNA-binding motif	0	DIRECT
Trimeric LpxA-like enzymes	0	DIRECT
PEBP-like	0	DIRECT
IP3 receptor type 1 binding core, domain 2	0	DIRECT
Phosphoglucomutase, C-terminal domain	0	DIRECT
3-carboxy-cis,cis-mucoante lactonizing enzyme	0	DIRECT
A heparin-binding domain	0	DIRECT
Terpenoid synthases	0	DIRECT
His-Me finger endonucleases	0	DIRECT
L27 domain	0	DIRECT
Chicken cartilage matrix protein	0	DIRECT
TSP type-3 repeat	0	DIRECT
AraD/HMP-PK domain-like	0	DIRECT
N-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
PriA/YqbF domain	0	DIRECT
Metallothionein	0	DIRECT
ClpS-like	0	DIRECT
NAD(P)-binding Rossmann-fold domains	0.001316	INHERITED FROM: Arsenic Trioxide || Sulfates
PH domain-like	0.003571	INHERITED FROM: Chromates || Silicon Dioxide
Protein kinase-like (PK-like)	0.005684	INHERITED FROM: calcium silicate || Chromates || Arsenites || Hypochlorous Acid || Nitrates || Silicic Acid || Chlorides || Silicates || diallyl disulfide || Asbestos
Integrin domains	0.005802	INHERITED FROM: Aluminum Oxide || Sulfides || Chlorides
Rhodanese/Cell cycle control phosphatase	0.01168	INHERITED FROM: Asbestos, Crocidolite || Chromates || Arsenites || Asbestos, Amphibole
Interleukin 8-like chemokines	0.01611	INHERITED FROM: Fluorides || Magnesium Silicates || cobalt oxide || Asbestos, Serpentine || zinc chloride || Hydroxides || Chlorides || Zinc Oxide || Asbestos || sodium bichromate || Aluminum Hydroxide || Alum Compounds
Leucine zipper domain	0.01739	INHERITED FROM: Arsenites || Hypochlorous Acid || Silicic Acid || Sulfides || Peroxides || Chlorides || Asbestos || cadmium sulfate || Sulfates
Thioredoxin-like	0.01878	INHERITED FROM: Mercuric Chloride || Lipid Peroxides || 2,2'-dihydroxy-6,6'-dinaphthyldisulfide || Sulfides
EGF/Laminin	0.02681	INHERITED FROM: Arsenites || Vanadates || Silicon Dioxide || Sulfides || Chlorides
Class II aaRS and biotin synthetases	0.03041	INHERITED FROM: Copper Sulfate || Sulfates
Kringle-like	0.03085	INHERITED FROM: Aluminum Oxide || Disulfiram || Sulfides || sodium bisulfide
Histone-fold	0.03381	INHERITED FROM: Silicon Dioxide || Copper Sulfate || Sulfates
DEATH domain	0.03931	INHERITED FROM: Fluorides || zinc sulfide || Silicic Acid || Sodium Fluoride || Sulfides || Arsenic Trioxide || Magnesium Oxide || Asbestos || tetraarsenic tetrasulfide
p53-like transcription factors	0.05237	INHERITED FROM: artemisinine || Asbestos, Crocidolite || Arsenites || Sodium Chloride || Nitroprusside || arsenite || Cyanides || Sodium Fluoride || pervanadate || Zinc Oxide || Zinc Sulfate
Bromodomain	0.05278	INHERITED FROM: Superoxides
(Phosphotyrosine protein) phosphatases II	0.0708	INHERITED FROM: Vanadates || oxovanadium IV
Alkaline phosphatase-like	0.07143	INHERITED FROM: Vanadates
Nuclear receptor ligand-binding domain	0.07262	INHERITED FROM: Arsenites || Artemisinins
Cyclin-like	0.07445	INHERITED FROM: Nitrates || Lithium Chloride || Sulfides || Peroxides || tetraarsenic tetrasulfide
Ferredoxin reductase-like, C-terminal NADP-linked domain	0.07603	INHERITED FROM: Nitroprusside || Nitrogen Oxides || Cyanides || Superoxides || Nitric Oxide
Riboflavin synthase domain-like	0.07603	INHERITED FROM: Nitroprusside || Nitrogen Oxides || Cyanides || Superoxides || Nitric Oxide
ALDH-like	0.07603	INHERITED FROM: Phosphoramide Mustards || Phosphoramides || Phosphates || perfosfamide
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0.07752	INHERITED FROM: sodium arsenite
Complement control module/SCR domain	0.08308	INHERITED FROM: Arsenites
GST C-terminal domain-like	0.08327	INHERITED FROM: Lipid Peroxides || Artemisinins
Thyroglobulin type-1 domain	0.102	INHERITED FROM: Bromides || Arsenites || Arsenates || Phosphoramide Mustards || mercuric bromide
PLC-like phosphodiesterases	0.1182	INHERITED FROM: Asbestos
Serpins	0.1329	INHERITED FROM: Arsenites || Silicon Dioxide || sodium arsenite
Tubulin nucleotide-binding domain-like	0.1367	INHERITED FROM: Oxides
SH2 domain	0.1396	INHERITED FROM: Arsenic Trioxide || pervanadate
TNF receptor-like	0.1477	INHERITED FROM: Fluorides || Arsenic Trioxide || Magnesium Oxide
Growth factor receptor domain	0.1482	INHERITED FROM: Arsenates || CMF regimen || Chlorides
Putative DNA-binding domain	0.1552	INHERITED FROM: Sulfides
Heme-dependent peroxidases	0.1552	INHERITED FROM: Fluorides || Nitrogen Dioxide || Nitrogen Oxides || Sodium Fluoride
GLA-domain	0.1571	INHERITED FROM: Calcium Chloride
Hemopexin-like domain	0.1576	INHERITED FROM: Aluminum Oxide || dihydroartemisinin || Vanadates
A DNA-binding domain in eukaryotic transcription factors	0.1788	INHERITED FROM: Potassium Dichromate || Arsenites || Hypochlorous Acid || Disulfides || zinc chloride || Sulfides || Peroxides || mercuric bromide
Annexin	0.1806	INHERITED FROM: Bromides || Oxides
Pseudouridine synthase	0.1806	INHERITED FROM: Copper Sulfate
Integrin alpha N-terminal domain	0.1855	INHERITED FROM: Aluminum Oxide || Sulfides
Nucleotidylyl transferase	0.2109	INHERITED FROM: Ifosfamide
Cytochrome P450	0.2241	INHERITED FROM: artemisinine || Arsenites || rabeprazole-thioether || n-propyl disulfide || 4-hydroxycyclophosphamide || Phosphoramides || Phosphates || Celsior || dechloroethylcyclophosphamide || Ifosfamide || dipropyl sulfide || allyl sulfide
Inhibitor of apoptosis (IAP) repeat	0.2304	INHERITED FROM: Fluorides || Nitrogen Oxides || Disulfides || Sulfides || diallyl disulfide || ajoene || allyl sulfide || Nitric Oxide
Ricin B-like lectins	0.2317	INHERITED FROM: potassium chromate(VI)
Glucocorticoid receptor-like (DNA-binding domain)	0.2364	INHERITED FROM: Arsenites || arsenite || Artemisinins
PGBD-like	0.2708	INHERITED FROM: Aluminum Oxide || Cadmium Chloride || dihydroartemisinin || Vanadates || Disulfides || Artemisinins || diallyl disulfide || allyl sulfide
FAD/NAD(P)-binding domain	0.2739	INHERITED FROM: cadmium sulfide
Thiolase-like	0.2746	INHERITED FROM: Potassium Dichromate || Sulfates
Flavoproteins	0.2746	INHERITED FROM: Hydrogen Peroxide || Nitroprusside || Nitrogen Oxides || diallyl trisulfide || Cyanides || Nitric Oxide
Heat shock protein 70kD (HSP70), C-terminal subdomain	0.2746	INHERITED FROM: Disulfiram || Phosphoramide Mustards || Nitrates || Phosphoramides || Asbestos, Amphibole || Phosphates || Silicic Acid || Sulfides || Arsenic Trioxide || Silicates || sodium arsenite || Asbestos || cadmium sulfate
Toll/Interleukin receptor TIR domain	0.2787	INHERITED FROM: zinc sulfide || Sulfides
CAD & PB1 domains	0.2865	INHERITED FROM: Fluorides
Actin-like ATPase domain	0.2893	INHERITED FROM: Nitrates || Sulfides
E2F-DP heterodimerization region	0.3141	INHERITED FROM: Nitrates || Silver Nitrate || Arsenic Trioxide
HSP40/DnaJ peptide-binding domain	0.3141	INHERITED FROM: Disulfiram || Disulfides
Carbonic anhydrase	0.3168	INHERITED FROM: Carbonates || sodium metasilicate || chloric acid || Vanadates || Iodates || Chlorates || Bromates
Metalloproteases ("zincins"), catalytic domain	0.3362	INHERITED FROM: Aluminum Oxide
Eukaryotic type KH-domain (KH-domain type I)	0.3549	INHERITED FROM: dihydroartemisinin
FnI-like domain	0.3555	INHERITED FROM: Bromides || mercuric bromide
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	0.3767	INHERITED FROM: Sulfides
FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0.411	INHERITED FROM: Arsenates || Disulfiram || Mercuric Chloride || Disulfides || Phosphates
Ferritin-like	0.411	INHERITED FROM: diallyl trisulfide || sodium arsenite
4-helical cytokines	0.4135	INHERITED FROM: Nitroprusside || Nitrites || FEC protocol || Nitrates || mineral trioxide aggregate || Mercuric Chloride || Nitrogen Oxides || Phosphates || Cyanides || Silicic Acid || Hydroxides || Chlorides || sodium bisulfide || Aluminum Chloride || Asbestos || sodium bichromate || Alum Compounds || Polyphosphates || Nitric Oxide
TSP-1 type 1 repeat	0.4136	INHERITED FROM: mercuric bromide
RCC1/BLIP-II	0.4245	INHERITED FROM: Chromates
PAP/OAS1 substrate-binding domain	0.4268	INHERITED FROM: Magnesium Silicates || Asbestos, Serpentine
HSP20-like chaperones	0.4271	INHERITED FROM: Disulfiram || Disulfides
Nucleic acid-binding proteins	0.4297	INHERITED FROM: Peroxides
Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain	0.4324	INHERITED FROM: potassium chromate(VI)
Ribosomal protein S5 domain 2-like	0.4362	INHERITED FROM: Cadmium Chloride
Spermadhesin, CUB domain	0.4401	INHERITED FROM: Bromides || mercuric bromide
Calponin-homology domain, CH-domain	0.4681	INHERITED FROM: dihydroartemisinin
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases	0.4694	INHERITED FROM: Ifosfamide
ABC transporter transmembrane region	0.4771	INHERITED FROM: Fluorides || Phosphoramides || Sulfides || diallyl disulfide || allyl sulfide
SET domain	0.4832	INHERITED FROM: Nitrogen Oxides || Nitric Oxide
LDH C-terminal domain-like	0.4919	INHERITED FROM: dihydroartemisinin || Artemisinins
Cation efflux protein transmembrane domain-like	0.5626	INHERITED FROM: zinc chloride
TNF-like	0.5649	INHERITED FROM: Fluorides || Aluminum Oxide
Cadherin-like	0.5681	INHERITED FROM: Magnesium Silicates || arsenite || Asbestos, Serpentine
Kazal-type serine protease inhibitors	0.5806	INHERITED FROM: Arsenites
"Winged helix" DNA-binding domain	0.5833	INHERITED FROM: Nitrates || Silver Nitrate
NAD(P)-linked oxidoreductase	0.6137	INHERITED FROM: Disulfiram || Phosphoramide Mustards || Disulfides || Phosphates || Sulfides || cadmium sulfate
Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain	0.6139	INHERITED FROM: Asbestos, Crocidolite || Asbestos, Amphibole || Asbestos
Cytokine	0.641	INHERITED FROM: Sodium Chloride || zinc sulfide || Hydroxides || Alum Compounds
Frizzled cysteine-rich domain	0.6851	INHERITED FROM: Arsenates || Lithium Chloride
HLH, helix-loop-helix DNA-binding domain	0.7042	INHERITED FROM: arsenite
MHC antigen-recognition domain	0.7163	INHERITED FROM: Phosphoramides
SMAD/FHA domain	0.739	INHERITED FROM: Silver Nitrate
Clavaminate synthase-like	0.7468	INHERITED FROM: Nitrogen Oxides || Nitric Oxide
Homeodomain-like	0.8175	INHERITED FROM: Arsenites || arsenite
Aquaporin-like	0.8864	INHERITED FROM: Mercuric Chloride || Hydroxides || Water
Intermediate filament protein, coiled coil region	0.8869	INHERITED FROM: arsenite
Trypsin-like serine proteases	0.9674	INHERITED FROM: Calcium Chloride
Cystine-knot cytokines	0.996	INHERITED FROM: Aluminum Oxide || Sodium Chloride || chromous chloride || Chlorides
RING/U-box	1	INHERITED FROM: Sodium Hydroxide
Family A G protein-coupled receptor-like	1	INHERITED FROM: Asbestos, Crocidolite
Immunoglobulin	1	INHERITED FROM: Aluminum Hydroxide
L domain-like	1	INHERITED FROM: CMF regimen
B-box zinc-binding domain	1	INHERITED FROM: Sodium Hydroxide

Supra-domain (Duplex) in N- to C-terminal order

Highlighted in gray are those with FDR>0.001

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
52540,51045 52540 - P-loop containing nucleoside triphosphate hydrolases 51045 - WW domain	0	DIRECT
81631,55003 81631 - PAP/OAS1 substrate-binding domain 55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain	0	DIRECT
48403,56112 48403 - Ankyrin repeat 56112 - Protein kinase-like (PK-like)	0	DIRECT
50044,56112 50044 - SH3-domain 56112 - Protein kinase-like (PK-like)	0	DIRECT
47005,52777 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex 52777 - CoA-dependent acyltransferases	0	DIRECT
47473,55550 47473 - EF-hand 55550 - SH2 domain	0	DIRECT
52540,53254 52540 - P-loop containing nucleoside triphosphate hydrolases 53254 - Phosphoglycerate mutase-like	0	DIRECT
46942,57783 46942 - Elongation factor TFIIS domain 2 57783 - Zinc beta-ribbon	0	DIRECT
48366,47473 48366 - Ras GEF 47473 - EF-hand	0	DIRECT
57440,50494 57440 - Kringle-like 50494 - Trypsin-like serine proteases	0	DIRECT
82754,82754 82754 - C-terminal, gelsolin-like domain of Sec23/24 82754 - C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
82199,57903 82199 - SET domain 57903 - FYVE/PHD zinc finger	0	DIRECT
100920,100934 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
54211,55060 54211 - Ribosomal protein S5 domain 2-like 55060 - GHMP Kinase, C-terminal domain	0	DIRECT
69572,69572 69572 - Activating enzymes of the ubiquitin-like proteins 69572 - Activating enzymes of the ubiquitin-like proteins	0	DIRECT
47353,109640 47353 - Retrovirus capsid dimerization domain-like 109640 - KRAB domain (Kruppel-associated box)	0	DIRECT
55550,50729 55550 - SH2 domain 50729 - PH domain-like	0	DIRECT
54909,54909 54909 - Dimeric alpha+beta barrel 54909 - Dimeric alpha+beta barrel	0	DIRECT
57196,50494 57196 - EGF/Laminin 50494 - Trypsin-like serine proteases	0	DIRECT
82754,55753 82754 - C-terminal, gelsolin-like domain of Sec23/24 55753 - Actin depolymerizing proteins	0	DIRECT
47661,58038 47661 - t-snare proteins 58038 - SNARE fusion complex	0	DIRECT
49265,53300 49265 - Fibronectin type III 53300 - vWA-like	0	DIRECT
102848,54236 102848 - NSFL1 (p97 ATPase) cofactor p47, SEP domain 54236 - Ubiquitin-like	0	DIRECT
47220,47220 47220 - alpha-catenin/vinculin-like 47220 - alpha-catenin/vinculin-like	0	DIRECT
55874,54211 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 54211 - Ribosomal protein S5 domain 2-like	0	DIRECT
82671,49854 82671 - SEA domain 49854 - Spermadhesin, CUB domain	0	DIRECT
53927,53927 53927 - Cytidine deaminase-like 53927 - Cytidine deaminase-like	0	DIRECT
56801,56801 56801 - Acetyl-CoA synthetase-like 56801 - Acetyl-CoA synthetase-like	0	DIRECT
90188,90188 90188 - Somatomedin B domain 90188 - Somatomedin B domain	0	DIRECT
57414,57440 57414 - Hairpin loop containing domain-like 57440 - Kringle-like	0	DIRECT
49348,55711 49348 - Clathrin adaptor appendage domain 55711 - Subdomain of clathrin and coatomer appendage domain	0	DIRECT
57903,63748 57903 - FYVE/PHD zinc finger 63748 - Tudor/PWWP/MBT	0	DIRECT
47668,47473 47668 - N-terminal domain of cbl (N-cbl) 47473 - EF-hand	0	DIRECT
47576,140612 47576 - Calponin-homology domain, CH-domain 140612 - EB1 dimerisation domain-like	0	DIRECT
55550,55550 55550 - SH2 domain 55550 - SH2 domain	0	DIRECT
54534,54534 54534 - FKBP-like 54534 - FKBP-like	0	DIRECT
55486,48371 55486 - Metalloproteases ("zincins"), catalytic domain 48371 - ARM repeat	0	DIRECT
103637,103637 103637 - CCHHC domain 103637 - CCHHC domain	0	DIRECT
49742,49742 49742 - PHM/PNGase F 49742 - PHM/PNGase F	0	DIRECT
54236,57889 54236 - Ubiquitin-like 57889 - Cysteine-rich domain	0	DIRECT
54211,55666 54211 - Ribosomal protein S5 domain 2-like 55666 - Ribonuclease PH domain 2-like	0	DIRECT
103575,48726 103575 - Plexin repeat 48726 - Immunoglobulin	0	DIRECT
57630,57196 57630 - GLA-domain 57196 - EGF/Laminin	0	DIRECT
49417,55550 49417 - p53-like transcription factors 55550 - SH2 domain	0	DIRECT
53098,54928 53098 - Ribonuclease H-like 54928 - RNA-binding domain, RBD	0	DIRECT
48464,89009 48464 - ENTH/VHS domain 89009 - GAT-like domain	0	DIRECT
53300,49265 53300 - vWA-like 49265 - Fibronectin type III	0	DIRECT
54001,143791 54001 - Cysteine proteinases 143791 - DUSP-like	0	DIRECT
50978,50998 50978 - WD40 repeat-like 50998 - Quinoprotein alcohol dehydrogenase-like	0	DIRECT
53732,52016 53732 - Aconitase iron-sulfur domain 52016 - LeuD/IlvD-like	0	DIRECT
81296,101898 81296 - E set domains 101898 - NHL repeat	0	DIRECT
57196,90193 57196 - EGF/Laminin 90193 - Notch domain	0	DIRECT
74924,74924 74924 - Cap-Gly domain 74924 - Cap-Gly domain	0	DIRECT
53850,53850 53850 - Periplasmic binding protein-like II 53850 - Periplasmic binding protein-like II	0	DIRECT
52799,52799 52799 - (Phosphotyrosine protein) phosphatases II 52799 - (Phosphotyrosine protein) phosphatases II	0	DIRECT
55326,56042 55326 - PurM N-terminal domain-like 56042 - PurM C-terminal domain-like	0	DIRECT
57535,50494 57535 - Complement control module/SCR domain 50494 - Trypsin-like serine proteases	0	DIRECT
51419,50621 51419 - PLP-binding barrel 50621 - Alanine racemase C-terminal domain-like	0	DIRECT
48670,48097 48670 - Transducin (heterotrimeric G protein), gamma chain 48097 - Regulator of G-protein signaling, RGS	0	DIRECT
103647,49899 103647 - TSP type-3 repeat 49899 - Concanavalin A-like lectins/glucanases	0	DIRECT
53822,53850 53822 - Periplasmic binding protein-like I 53850 - Periplasmic binding protein-like II	0	DIRECT
56672,100879 56672 - DNA/RNA polymerases 100879 - Lesion bypass DNA polymerase (Y-family), little finger domain	0	DIRECT
53067,100920 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
55753,47050 55753 - Actin depolymerizing proteins 47050 - VHP, Villin headpiece domain	0	DIRECT
55550,50044 55550 - SH2 domain 50044 - SH3-domain	0	DIRECT
57924,57924 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat	0	DIRECT
50729,57889 50729 - PH domain-like 57889 - Cysteine-rich domain	0	DIRECT
50692,54585 50692 - ADC-like 54585 - Cdc48 domain 2-like	0	DIRECT
55186,55681 55186 - ThrRS/AlaRS common domain 55681 - Class II aaRS and biotin synthetases	0	DIRECT
57850,52540 57850 - RING/U-box 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
47060,55681 47060 - S15/NS1 RNA-binding domain 55681 - Class II aaRS and biotin synthetases	0	DIRECT
52283,51735 52283 - Formate/glycerate dehydrogenase catalytic domain-like 51735 - NAD(P)-binding Rossmann-fold domains	0	DIRECT
90209,90209 90209 - Ran binding protein zinc finger-like 90209 - Ran binding protein zinc finger-like	0	DIRECT
46689,57667 46689 - Homeodomain-like 57667 - beta-beta-alpha zinc fingers	0	DIRECT
51230,47005 51230 - Single hybrid motif 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex	0	DIRECT
46565,57938 46565 - Chaperone J-domain 57938 - DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
56059,51246 56059 - Glutathione synthetase ATP-binding domain-like 51246 - Rudiment single hybrid motif	0	DIRECT
47986,52129 47986 - DEATH domain 52129 - Caspase-like	0	DIRECT
53300,57184 53300 - vWA-like 57184 - Growth factor receptor domain	0	DIRECT
57667,90229 57667 - beta-beta-alpha zinc fingers 90229 - CCCH zinc finger	0	DIRECT
49417,81296 49417 - p53-like transcription factors 81296 - E set domains	0	DIRECT
47587,56399 47587 - Domain of poly(ADP-ribose) polymerase 56399 - ADP-ribosylation	0	DIRECT
53300,69179 53300 - vWA-like 69179 - Integrin domains	0	DIRECT
57184,49265 57184 - Growth factor receptor domain 49265 - Fibronectin type III	0	DIRECT
57440,56436 57440 - Kringle-like 56436 - C-type lectin-like	0	DIRECT
47473,51695 47473 - EF-hand 51695 - PLC-like phosphodiesterases	0	DIRECT
52743,49785 52743 - Subtilisin-like 49785 - Galactose-binding domain-like	0	DIRECT
53328,50486 53328 - Formyltransferase 50486 - FMT C-terminal domain-like	0	DIRECT
52058,52047 52058 - L domain-like 52047 - RNI-like	0	DIRECT
49695,50370 49695 - gamma-Crystallin-like 50370 - Ricin B-like lectins	0	DIRECT
100934,100934 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
48350,55961 48350 - GTPase activation domain, GAP 55961 - Bet v1-like	0	DIRECT
47676,46942 47676 - Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 46942 - Elongation factor TFIIS domain 2	0	DIRECT
46785,54928 46785 - "Winged helix" DNA-binding domain 54928 - RNA-binding domain, RBD	0	DIRECT
57184,49854 57184 - Growth factor receptor domain 49854 - Spermadhesin, CUB domain	0	DIRECT
48452,46785 48452 - TPR-like 46785 - "Winged helix" DNA-binding domain	0	DIRECT
82199,57667 82199 - SET domain 57667 - beta-beta-alpha zinc fingers	0	DIRECT
101288,50156 101288 - L27 domain 50156 - PDZ domain-like	0	DIRECT
48403,47986 48403 - Ankyrin repeat 47986 - DEATH domain	0	DIRECT
52113,52113 52113 - BRCT domain 52113 - BRCT domain	0	DIRECT
52980,47781 52980 - Restriction endonuclease-like 47781 - RuvA domain 2-like	0	DIRECT
49899,48726 49899 - Concanavalin A-like lectins/glucanases 48726 - Immunoglobulin	0	DIRECT
47370,47370 47370 - Bromodomain 47370 - Bromodomain	0	DIRECT
75399,75399 75399 - Plakin repeat 75399 - Plakin repeat	0	DIRECT
82109,82109 82109 - MIR domain 82109 - MIR domain	0	DIRECT
103647,103647 103647 - TSP type-3 repeat 103647 - TSP type-3 repeat	0	DIRECT
47655,49417 47655 - STAT 49417 - p53-like transcription factors	0	DIRECT
56112,56112 56112 - Protein kinase-like (PK-like) 56112 - Protein kinase-like (PK-like)	0	DIRECT
50447,54980 50447 - Translation proteins 54980 - EF-G C-terminal domain-like	0	DIRECT
49417,47719 49417 - p53-like transcription factors 47719 - p53 tetramerization domain	0	DIRECT
56436,57535 56436 - C-type lectin-like 57535 - Complement control module/SCR domain	0	DIRECT
81383,49785 81383 - F-box domain 49785 - Galactose-binding domain-like	0	DIRECT
54416,54416 54416 - Amine oxidase N-terminal region 54416 - Amine oxidase N-terminal region	0	DIRECT
81324,53850 81324 - Voltage-gated potassium channels 53850 - Periplasmic binding protein-like II	0	DIRECT
117839,56399 117839 - WWE domain 56399 - ADP-ribosylation	0	DIRECT
47576,48065 47576 - Calponin-homology domain, CH-domain 48065 - DBL homology domain (DH-domain)	0	DIRECT
49723,48484 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain) 48484 - Lipoxigenase	0	DIRECT
90193,90193 90193 - Notch domain 90193 - Notch domain	0	DIRECT
54919,54919 54919 - Nucleoside diphosphate kinase, NDK 54919 - Nucleoside diphosphate kinase, NDK	0	DIRECT
53784,53784 53784 - Phosphofructokinase 53784 - Phosphofructokinase	0	DIRECT
63748,82199 63748 - Tudor/PWWP/MBT 82199 - SET domain	0	DIRECT
57184,57610 57184 - Growth factor receptor domain 57610 - Thyroglobulin type-1 domain	0	DIRECT
56112,50729 56112 - Protein kinase-like (PK-like) 50729 - PH domain-like	0	DIRECT
53738,55957 53738 - Phosphoglucomutase, first 3 domains 55957 - Phosphoglucomutase, C-terminal domain	0	DIRECT
142921,47587 142921 - WGR domain-like 47587 - Domain of poly(ADP-ribose) polymerase	0	DIRECT
69012,55874 69012 - alpha-ketoacid dehydrogenase kinase, N-terminal domain 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	0	DIRECT
64593,90257 64593 - Intermediate filament protein, coiled coil region 90257 - Myosin rod fragments	0	DIRECT
50156,50044 50156 - PDZ domain-like 50044 - SH3-domain	0	DIRECT
-7,56112 -7 - CATH 56112 - Protein kinase-like (PK-like)	0	DIRECT
81324,81327 81324 - Voltage-gated potassium channels 81327 - Small-conductance potassium channel	0	DIRECT
55753,82754 55753 - Actin depolymerizing proteins 82754 - C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
57938,49493 57938 - DnaJ/Hsp40 cysteine-rich domain 49493 - HSP40/DnaJ peptide-binding domain	0	DIRECT
54236,50729 54236 - Ubiquitin-like 50729 - PH domain-like	0	DIRECT
63763,57903 63763 - SAND domain-like 57903 - FYVE/PHD zinc finger	0	DIRECT
48452,57850 48452 - TPR-like 57850 - RING/U-box	0	DIRECT
52540,47917 52540 - P-loop containing nucleoside triphosphate hydrolases 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase	0	DIRECT
48452,48403 48452 - TPR-like 48403 - Ankyrin repeat	0	DIRECT
46585,46585 46585 - HR1 repeat 46585 - HR1 repeat	0	DIRECT
54897,52743 54897 - Protease propeptides/inhibitors 52743 - Subtilisin-like	0	DIRECT
57850,88697 57850 - RING/U-box 88697 - PUA domain-like	0	DIRECT
51445,54556 51445 - (Trans)glycosidases 54556 - Chitinase insertion domain	0	DIRECT
50044,52540 50044 - SH3-domain 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
46966,47473 46966 - Spectrin repeat 47473 - EF-hand	0	DIRECT
100895,100895 100895 - Kazal-type serine protease inhibitors 100895 - Kazal-type serine protease inhibitors	0	DIRECT
57424,50494 57424 - LDL receptor-like module 50494 - Trypsin-like serine proteases	0	DIRECT
49265,56112 49265 - Fibronectin type III 56112 - Protein kinase-like (PK-like)	0	DIRECT
52777,52777 52777 - CoA-dependent acyltransferases 52777 - CoA-dependent acyltransferases	0	DIRECT
82109,100909 82109 - MIR domain 100909 - IP3 receptor type 1 binding core, domain 2	0	DIRECT
102712,-7 102712 - JAB1/MPN domain -7 - CATH	0	DIRECT
47459,158457 47459 - HLH, helix-loop-helix DNA-binding domain 158457 - Orange domain-like	0	DIRECT
49854,57196 49854 - Spermadhesin, CUB domain 57196 - EGF/Laminin	0	DIRECT
56491,89811 56491 - A heparin-binding domain 89811 - Amyloid beta a4 protein copper binding domain (domain 2)	0	DIRECT
49562,57889 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 57889 - Cysteine-rich domain	0	DIRECT
48552,48552 48552 - Serum albumin-like 48552 - Serum albumin-like	0	DIRECT
54826,51604 54826 - Enolase N-terminal domain-like 51604 - Enolase C-terminal domain-like	0	DIRECT
54637,54637 54637 - Thioesterase/thiol ester dehydrase-isomerase 54637 - Thioesterase/thiol ester dehydrase-isomerase	0	DIRECT
47986,47986 47986 - DEATH domain 47986 - DEATH domain	0	DIRECT
48403,48452 48403 - Ankyrin repeat 48452 - TPR-like	0	DIRECT
49899,63887 49899 - Concanavalin A-like lectins/glucanases 63887 - P-domain of calnexin/calreticulin	0	DIRECT
57850,48452 57850 - RING/U-box 48452 - TPR-like	0	DIRECT
50249,55681 50249 - Nucleic acid-binding proteins 55681 - Class II aaRS and biotin synthetases	0	DIRECT
50249,46785 50249 - Nucleic acid-binding proteins 46785 - "Winged helix" DNA-binding domain	0	DIRECT
56091,50249 56091 - DNA ligase/mRNA capping enzyme, catalytic domain 50249 - Nucleic acid-binding proteins	0	DIRECT
53098,56672 53098 - Ribonuclease H-like 56672 - DNA/RNA polymerases	0	DIRECT
53738,53738 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains	0	DIRECT
48034,55931 48034 - Guanido kinase N-terminal domain 55931 - Glutamine synthetase/guanido kinase	0	DIRECT
63748,57903 63748 - Tudor/PWWP/MBT 57903 - FYVE/PHD zinc finger	0	DIRECT
52087,48350 52087 - CRAL/TRIO domain 48350 - GTPase activation domain, GAP	0	DIRECT
47473,57889 47473 - EF-hand 57889 - Cysteine-rich domain	0	DIRECT
56059,52210 56059 - Glutathione synthetase ATP-binding domain-like 52210 - Succinyl-CoA synthetase domains	0	DIRECT
51695,49562 51695 - PLC-like phosphodiesterases 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)	0	DIRECT
54403,54403 54403 - Cystatin/monellin 54403 - Cystatin/monellin	0	DIRECT
52821,52799 52821 - Rhodanese/Cell cycle control phosphatase 52799 - (Phosphotyrosine protein) phosphatases II	0	DIRECT
54416,49998 54416 - Amine oxidase N-terminal region 49998 - Amine oxidase catalytic domain	0	DIRECT
50129,51735 50129 - GroES-like 51735 - NAD(P)-binding Rossmann-fold domains	0	DIRECT
48092,47655 48092 - Transcription factor STAT-4 N-domain 47655 - STAT	0	DIRECT
50370,57440 50370 - Ricin B-like lectins 57440 - Kringle-like	0	DIRECT
51735,50129 51735 - NAD(P)-binding Rossmann-fold domains 50129 - GroES-like	0	DIRECT
57196,69687 57196 - EGF/Laminin 69687 - Integrin beta tail domain	0	DIRECT
117018,56091 117018 - ATP-dependent DNA ligase DNA-binding domain 56091 - DNA ligase/mRNA capping enzyme, catalytic domain	0	DIRECT
90188,53649 90188 - Somatomedin B domain 53649 - Alkaline phosphatase-like	0	DIRECT
57889,49562 57889 - Cysteine-rich domain 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)	0	DIRECT
50156,52540 50156 - PDZ domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
55486,49854 55486 - Metalloproteases ("zincins"), catalytic domain 49854 - Spermadhesin, CUB domain	0	DIRECT
54534,47473 54534 - FKBP-like 47473 - EF-hand	0	DIRECT
81606,81601 81606 - PP2C-like 81601 - Protein serine/threonine phosphatase 2C, C-terminal domain	0	DIRECT
55550,57850 55550 - SH2 domain 57850 - RING/U-box	0	DIRECT
52540,57774 52540 - P-loop containing nucleoside triphosphate hydrolases 57774 - Microbial and mitochondrial ADK, insert "zinc finger" domain	0	DIRECT
50729,47473 50729 - PH domain-like 47473 - EF-hand	0	DIRECT
48403,52540 48403 - Ankyrin repeat 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
54695,54695 54695 - POZ domain 54695 - POZ domain	0	DIRECT
47954,47954 47954 - Cyclin-like 47954 - Cyclin-like	0.005802	INHERITED FROM: Nitrates || Lithium Chloride || tetraarsenic tetrasulfide
57716,48508 57716 - Glucocorticoid receptor-like (DNA-binding domain) 48508 - Nuclear receptor ligand-binding domain	0.01371	INHERITED FROM: Artemisinins
69318,69179 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains	0.02876	INHERITED FROM: Aluminum Oxide || Sulfides
69179,69179 69179 - Integrin domains 69179 - Integrin domains	0.02876	INHERITED FROM: Aluminum Oxide || Sulfides
57184,57184 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain	0.05635	INHERITED FROM: potassium chromate(VI)
57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain)	0.06974	INHERITED FROM: Bromides || arsenite || mercuric bromide
57535,57535 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain	0.07445	INHERITED FROM: Arsenites
57586,57586 57586 - TNF receptor-like 57586 - TNF receptor-like	0.07603	INHERITED FROM: Bromides || Fluorides || Arsenic Trioxide || Magnesium Oxide || mercuric bromide
47459,55785 47459 - HLH, helix-loop-helix DNA-binding domain 55785 - PYP-like sensor domain (PAS domain)	0.102	INHERITED FROM: potassium chromate(VI)
52833,47616 52833 - Thioredoxin-like 47616 - GST C-terminal domain-like	0.1036	INHERITED FROM: Lipid Peroxides || Artemisinins
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin	0.1762	INHERITED FROM: Arsenites || Vanadates || Chlorides
49785,57184 49785 - Galactose-binding domain-like 57184 - Growth factor receptor domain	0.2082	INHERITED FROM: Arsenates
103657,50729 103657 - BAR/IMD domain-like 50729 - PH domain-like	0.2082	INHERITED FROM: Chromates
47454,57959 47454 - A DNA-binding domain in eukaryotic transcription factors 57959 - Leucine zipper domain	0.2096	INHERITED FROM: Bromides || Potassium Dichromate || Arsenites || Hypochlorous Acid || Disulfides || zinc chloride || Sulfides || mercuric bromide
47090,55486 47090 - PGBD-like 55486 - Metalloproteases ("zincins"), catalytic domain	0.2708	INHERITED FROM: Aluminum Oxide || Cadmium Chloride || dihydroartemisinin || Vanadates || Disulfides || Artemisinins || diallyl disulfide || allyl sulfide
47031,50729 47031 - Second domain of FERM 50729 - PH domain-like	0.2734	INHERITED FROM: Silicon Dioxide
55550,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like)	0.2787	INHERITED FROM: Arsenic Trioxide
50729,55550 50729 - PH domain-like 55550 - SH2 domain	0.28	INHERITED FROM: Arsenic Trioxide
55486,50923 55486 - Metalloproteases ("zincins"), catalytic domain 50923 - Hemopexin-like domain	0.3063	INHERITED FROM: Aluminum Oxide
53901,53901 53901 - Thiolase-like 53901 - Thiolase-like	0.3141	INHERITED FROM: Sulfates
46785,144074 46785 - "Winged helix" DNA-binding domain 144074 - E2F-DP heterodimerization region	0.3141	INHERITED FROM: Nitrates || Silver Nitrate || Arsenic Trioxide
52540,90123 52540 - P-loop containing nucleoside triphosphate hydrolases 90123 - ABC transporter transmembrane region	0.3141	INHERITED FROM: Disulfides || diallyl trisulfide || diallyl disulfide
49562,48350 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48350 - GTPase activation domain, GAP	0.3141	INHERITED FROM: Asbestos
50729,48350 50729 - PH domain-like 48350 - GTPase activation domain, GAP	0.3507	INHERITED FROM: Chromates
52833,52833 52833 - Thioredoxin-like 52833 - Thioredoxin-like	0.3507	INHERITED FROM: tetraarsenic tetrasulfide
49493,49493 49493 - HSP40/DnaJ peptide-binding domain 49493 - HSP40/DnaJ peptide-binding domain	0.3599	INHERITED FROM: Disulfiram || Disulfides
57440,57440 57440 - Kringle-like 57440 - Kringle-like	0.3767	INHERITED FROM: Aluminum Oxide || Sulfides || sodium bisulfide
51735,55347 51735 - NAD(P)-binding Rossmann-fold domains 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	0.3767	INHERITED FROM: Sulfides
54236,47031 54236 - Ubiquitin-like 47031 - Second domain of FERM	0.383	INHERITED FROM: Silicon Dioxide
63748,63748 63748 - Tudor/PWWP/MBT 63748 - Tudor/PWWP/MBT	0.3868	INHERITED FROM: Nitrogen Oxides || Nitric Oxide
52058,57184 52058 - L domain-like 57184 - Growth factor receptor domain	0.411	INHERITED FROM: CMF regimen || Phosphoramides || Phosphates || sodium arsenite
57184,52058 57184 - Growth factor receptor domain 52058 - L domain-like	0.411	INHERITED FROM: CMF regimen || Phosphoramides || Phosphates || sodium arsenite
51905,55424 51905 - FAD/NAD(P)-binding domain 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain	0.411	INHERITED FROM: Arsenates || Disulfiram || Mercuric Chloride || Disulfides || Phosphates
57581,57196 57581 - TB module/8-cys domain 57196 - EGF/Laminin	0.411	INHERITED FROM: Cadmium Chloride
57196,57581 57196 - EGF/Laminin 57581 - TB module/8-cys domain	0.411	INHERITED FROM: Cadmium Chloride
53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain	0.4252	INHERITED FROM: Quartz || Sulfides || cadmium sulfate || Sulfates
56112,47769 56112 - Protein kinase-like (PK-like) 47769 - SAM/Pointed domain	0.4268	INHERITED FROM: Arsenates
81301,81631 81301 - Nucleotidyltransferase 81631 - PAP/OAS1 substrate-binding domain	0.4268	INHERITED FROM: Magnesium Silicates || Asbestos, Serpentine
52540,48340 52540 - P-loop containing nucleoside triphosphate hydrolases 48340 - Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain	0.4324	INHERITED FROM: potassium chromate(VI)
90123,52540 90123 - ABC transporter transmembrane region 52540 - P-loop containing nucleoside triphosphate hydrolases	0.4771	INHERITED FROM: Fluorides || Phosphoramides || Sulfides || diallyl disulfide || allyl sulfide
51735,56327 51735 - NAD(P)-binding Rossmann-fold domains 56327 - LDH C-terminal domain-like	0.4919	INHERITED FROM: dihydroartemisinin || Artemisinins
50729,52799 50729 - PH domain-like 52799 - (Phosphotyrosine protein) phosphatases II	0.4919	INHERITED FROM: Vanadates
57362,57362 57362 - BPTI-like 57362 - BPTI-like	0.5369	INHERITED FROM: Bromides || mercuric bromide
57603,82895 57603 - FnI-like domain 82895 - TSP-1 type 1 repeat	0.6139	INHERITED FROM: Cadmium Chloride
49313,49313 49313 - Cadherin-like 49313 - Cadherin-like	0.6244	INHERITED FROM: Magnesium Silicates || arsenite || Asbestos, Serpentine
53300,53300 53300 - vWA-like 53300 - vWA-like	0.8628	INHERITED FROM: Cadmium Chloride
57850,57845 57850 - RING/U-box 57845 - B-box zinc-binding domain	1	INHERITED FROM: Sodium Hydroxide || Hydroxides

Supra-domain (Triple) in N- to C-terminal order

Highlighted in gray are those with FDR>0.001

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
57184,52058,57184 57184 - Growth factor receptor domain 52058 - L domain-like 57184 - Growth factor receptor domain	0	DIRECT
54897,52743,49785 54897 - Protease propeptides/inhibitors 52743 - Subtilisin-like 49785 - Galactose-binding domain-like	0	DIRECT
48552,48552,48552 48552 - Serum albumin-like 48552 - Serum albumin-like 48552 - Serum albumin-like	0	DIRECT
90188,90188,53649 90188 - Somatomedin B domain 90188 - Somatomedin B domain 53649 - Alkaline phosphatase-like	0	DIRECT
57440,57440,50494 57440 - Kringle-like 57440 - Kringle-like 50494 - Trypsin-like serine proteases	0	DIRECT
52440,56059,51246 52440 - PreATP-grasp domain 56059 - Glutathione synthetase ATP-binding domain-like 51246 - Rudiment single hybrid motif	0	DIRECT
46585,46585,46585 46585 - HR1 repeat 46585 - HR1 repeat 46585 - HR1 repeat	0	DIRECT
47473,57889,57889 47473 - EF-hand 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain	0	DIRECT
47986,47986,52129 47986 - DEATH domain 47986 - DEATH domain 52129 - Caspase-like	0	DIRECT
52540,51045,51045 52540 - P-loop containing nucleoside triphosphate hydrolases 51045 - WW domain 51045 - WW domain	0	DIRECT
50729,57889,57889 50729 - PH domain-like 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain	0	DIRECT
50370,57440,56436 50370 - Ricin B-like lectins 57440 - Kringle-like 56436 - C-type lectin-like	0	DIRECT
55753,55753,47050 55753 - Actin depolymerizing proteins 55753 - Actin depolymerizing proteins 47050 - VHP, Villin headpiece domain	0	DIRECT
56436,56436,56436 56436 - C-type lectin-like 56436 - C-type lectin-like 56436 - C-type lectin-like	0	DIRECT
49562,57889,57889 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain	0	DIRECT
51230,47005,52777 51230 - Single hybrid motif 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex 52777 - CoA-dependent acyltransferases	0	DIRECT
55753,82754,82754 55753 - Actin depolymerizing proteins 82754 - C-terminal, gelsolin-like domain of Sec23/24 82754 - C-terminal, gelsolin-like domain of Sec23/24	0	DIRECT
47576,48065,50729 47576 - Calponin-homology domain, CH-domain 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like	0	DIRECT
47473,51695,49562 47473 - EF-hand 51695 - PLC-like phosphodiesterases 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)	0	DIRECT
47769,47769,47769 47769 - SAM/Pointed domain 47769 - SAM/Pointed domain 47769 - SAM/Pointed domain	0	DIRECT
50729,55550,56112 50729 - PH domain-like 55550 - SH2 domain 56112 - Protein kinase-like (PK-like)	0	DIRECT
63737,55486,48371 63737 - Leukotriene A4 hydrolase N-terminal domain 55486 - Metalloproteases ("zincins"), catalytic domain 48371 - ARM repeat	0	DIRECT
57586,57586,57586 57586 - TNF receptor-like 57586 - TNF receptor-like 57586 - TNF receptor-like	0	DIRECT
57850,48452,57850 57850 - RING/U-box 48452 - TPR-like 57850 - RING/U-box	0	DIRECT
47473,47473,57889 47473 - EF-hand 47473 - EF-hand 57889 - Cysteine-rich domain	0	DIRECT
57414,57440,57440 57414 - Hairpin loop containing domain-like 57440 - Kringle-like 57440 - Kringle-like	0	DIRECT
57196,57196,69687 57196 - EGF/Laminin 57196 - EGF/Laminin 69687 - Integrin beta tail domain	0	DIRECT
57184,100895,48726 57184 - Growth factor receptor domain 100895 - Kazal-type serine protease inhibitors 48726 - Immunoglobulin	0	DIRECT
57903,63748,82199 57903 - FYVE/PHD zinc finger 63748 - Tudor/PWWP/MBT 82199 - SET domain	0	DIRECT
82671,49854,49854 82671 - SEA domain 49854 - Spermadhesin, CUB domain 49854 - Spermadhesin, CUB domain	0	DIRECT
53067,53067,100920 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
81301,81631,55003 81301 - Nucleotidyltransferase 81631 - PAP/OAS1 substrate-binding domain 55003 - PAP/Archaeal CCA-adding enzyme, C-terminal domain	0	DIRECT
50156,52540,51045 50156 - PDZ domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases 51045 - WW domain	0	DIRECT
47459,55785,55785 47459 - HLH, helix-loop-helix DNA-binding domain 55785 - PYP-like sensor domain (PAS domain) 55785 - PYP-like sensor domain (PAS domain)	0	DIRECT
57424,57424,50494 57424 - LDL receptor-like module 57424 - LDL receptor-like module 50494 - Trypsin-like serine proteases	0	DIRECT
46565,57938,49493 46565 - Chaperone J-domain 57938 - DnaJ/Hsp40 cysteine-rich domain 49493 - HSP40/DnaJ peptide-binding domain	0	DIRECT
49899,48726,49265 49899 - Concanavalin A-like lectins/glucanases 48726 - Immunoglobulin 49265 - Fibronectin type III	0	DIRECT
49854,57196,49854 49854 - Spermadhesin, CUB domain 57196 - EGF/Laminin 49854 - Spermadhesin, CUB domain	0	DIRECT
49899,57196,49899 49899 - Concanavalin A-like lectins/glucanases 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases	0	DIRECT
47655,49417,55550 47655 - STAT 49417 - p53-like transcription factors 55550 - SH2 domain	0	DIRECT
82754,82754,55753 82754 - C-terminal, gelsolin-like domain of Sec23/24 82754 - C-terminal, gelsolin-like domain of Sec23/24 55753 - Actin depolymerizing proteins	0	DIRECT
82199,57667,57667 82199 - SET domain 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers	0	DIRECT
49854,57424,57424 49854 - Spermadhesin, CUB domain 57424 - LDL receptor-like module 57424 - LDL receptor-like module	0	DIRECT
57196,49854,57535 57196 - EGF/Laminin 49854 - Spermadhesin, CUB domain 57535 - Complement control module/SCR domain	0	DIRECT
57938,49493,49493 57938 - DnaJ/Hsp40 cysteine-rich domain 49493 - HSP40/DnaJ peptide-binding domain 49493 - HSP40/DnaJ peptide-binding domain	0	DIRECT
55486,49854,49854 55486 - Metalloproteases ("zincins"), catalytic domain 49854 - Spermadhesin, CUB domain 49854 - Spermadhesin, CUB domain	0	DIRECT
48452,57850,88697 48452 - TPR-like 57850 - RING/U-box 88697 - PUA domain-like	0	DIRECT
50729,47473,51695 50729 - PH domain-like 47473 - EF-hand 51695 - PLC-like phosphodiesterases	0	DIRECT
57630,57196,50494 57630 - GLA-domain 57196 - EGF/Laminin 50494 - Trypsin-like serine proteases	0	DIRECT
47668,47473,55550 47668 - N-terminal domain of cbl (N-cbl) 47473 - EF-hand 55550 - SH2 domain	0	DIRECT
48065,50729,50044 48065 - DBL homology domain (DH-domain) 50729 - PH domain-like 50044 - SH3-domain	0	DIRECT
101912,103575,48726 101912 - Sema domain 103575 - Plexin repeat 48726 - Immunoglobulin	0	DIRECT
49265,48726,48726 49265 - Fibronectin type III 48726 - Immunoglobulin 48726 - Immunoglobulin	0	DIRECT
101288,50156,50044 101288 - L27 domain 50156 - PDZ domain-like 50044 - SH3-domain	0	DIRECT
63763,57903,47370 63763 - SAND domain-like 57903 - FYVE/PHD zinc finger 47370 - Bromodomain	0	DIRECT
53067,100920,100934 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
49265,49265,53300 49265 - Fibronectin type III 49265 - Fibronectin type III 53300 - vWA-like	0	DIRECT
50729,57863,48403 50729 - PH domain-like 57863 - ArfGap/RecO-like zinc finger 48403 - Ankyrin repeat	0	DIRECT
63748,57903,57903 63748 - Tudor/PWWP/MBT 57903 - FYVE/PHD zinc finger 57903 - FYVE/PHD zinc finger	0	DIRECT
75399,75399,75399 75399 - Plakin repeat 75399 - Plakin repeat 75399 - Plakin repeat	0	DIRECT
57924,57924,57924 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat 57924 - Inhibitor of apoptosis (IAP) repeat	0	DIRECT
49785,57184,49265 49785 - Galactose-binding domain-like 57184 - Growth factor receptor domain 49265 - Fibronectin type III	0	DIRECT
64268,50044,50044 64268 - PX domain 50044 - SH3-domain 50044 - SH3-domain	0	DIRECT
50129,51735,50129 50129 - GroES-like 51735 - NAD(P)-binding Rossmann-fold domains 50129 - GroES-like	0	DIRECT
50044,50044,50044 50044 - SH3-domain 50044 - SH3-domain 50044 - SH3-domain	0	DIRECT
117018,56091,50249 117018 - ATP-dependent DNA ligase DNA-binding domain 56091 - DNA ligase/mRNA capping enzyme, catalytic domain 50249 - Nucleic acid-binding proteins	0	DIRECT
52743,49785,57184 52743 - Subtilisin-like 49785 - Galactose-binding domain-like 57184 - Growth factor receptor domain	0	DIRECT
53067,53067,53067 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain	0	DIRECT
50156,50044,52540 50156 - PDZ domain-like 50044 - SH3-domain 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
82109,82109,100909 82109 - MIR domain 82109 - MIR domain 100909 - IP3 receptor type 1 binding core, domain 2	0	DIRECT
47220,47220,47220 47220 - alpha-catenin/vinculin-like 47220 - alpha-catenin/vinculin-like 47220 - alpha-catenin/vinculin-like	0	DIRECT
103637,103637,103637 103637 - CCHHC domain 103637 - CCHHC domain 103637 - CCHHC domain	0	DIRECT
57196,57196,90193 57196 - EGF/Laminin 57196 - EGF/Laminin 90193 - Notch domain	0	DIRECT
48726,49265,56112 48726 - Immunoglobulin 49265 - Fibronectin type III 56112 - Protein kinase-like (PK-like)	0	DIRECT
55186,55681,52954 55186 - ThrRS/AlaRS common domain 55681 - Class II aaRS and biotin synthetases 52954 - Class II aaRS ABD-related	0	DIRECT
81271,55186,55681 81271 - TGS-like 55186 - ThrRS/AlaRS common domain 55681 - Class II aaRS and biotin synthetases	0	DIRECT
82754,55753,55753 82754 - C-terminal, gelsolin-like domain of Sec23/24 55753 - Actin depolymerizing proteins 55753 - Actin depolymerizing proteins	0	DIRECT
46966,46966,47473 46966 - Spectrin repeat 46966 - Spectrin repeat 47473 - EF-hand	0	DIRECT
50044,55550,50044 50044 - SH3-domain 55550 - SH2 domain 50044 - SH3-domain	0	DIRECT
53738,53738,53738 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains	0	DIRECT
57440,56436,56436 57440 - Kringle-like 56436 - C-type lectin-like 56436 - C-type lectin-like	0	DIRECT
53738,53738,55957 53738 - Phosphoglucomutase, first 3 domains 53738 - Phosphoglucomutase, first 3 domains 55957 - Phosphoglucomutase, C-terminal domain	0	DIRECT
57889,57889,49562 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)	0	DIRECT
52540,50447,54980 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins 54980 - EF-G C-terminal domain-like	0	DIRECT
55550,56112,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) 56112 - Protein kinase-like (PK-like)	0	DIRECT
54791,54791,54791 54791 - Eukaryotic type KH-domain (KH-domain type I) 54791 - Eukaryotic type KH-domain (KH-domain type I) 54791 - Eukaryotic type KH-domain (KH-domain type I)	0	DIRECT
47473,55550,57850 47473 - EF-hand 55550 - SH2 domain 57850 - RING/U-box	0	DIRECT
57535,57535,50494 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain 50494 - Trypsin-like serine proteases	0	DIRECT
49854,49854,57424 49854 - Spermadhesin, CUB domain 49854 - Spermadhesin, CUB domain 57424 - LDL receptor-like module	0	DIRECT
103647,103647,103647 103647 - TSP type-3 repeat 103647 - TSP type-3 repeat 103647 - TSP type-3 repeat	0	DIRECT
57196,57535,57535 57196 - EGF/Laminin 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain	0	DIRECT
103657,50729,48350 103657 - BAR/IMD domain-like 50729 - PH domain-like 48350 - GTPase activation domain, GAP	0	DIRECT
48092,47655,49417 48092 - Transcription factor STAT-4 N-domain 47655 - STAT 49417 - p53-like transcription factors	0	DIRECT
57184,57196,57184 57184 - Growth factor receptor domain 57196 - EGF/Laminin 57184 - Growth factor receptor domain	0	DIRECT
57196,57581,57196 57196 - EGF/Laminin 57581 - TB module/8-cys domain 57196 - EGF/Laminin	0	DIRECT
63748,82199,57903 63748 - Tudor/PWWP/MBT 82199 - SET domain 57903 - FYVE/PHD zinc finger	0	DIRECT
100895,100895,100895 100895 - Kazal-type serine protease inhibitors 100895 - Kazal-type serine protease inhibitors 100895 - Kazal-type serine protease inhibitors	0	DIRECT
103473,103473,141571 103473 - MFS general substrate transporter 103473 - MFS general substrate transporter 141571 - Pentapeptide repeat-like	0	DIRECT
54416,54416,49998 54416 - Amine oxidase N-terminal region 54416 - Amine oxidase N-terminal region 49998 - Amine oxidase catalytic domain	0	DIRECT
48366,47473,57889 48366 - Ras GEF 47473 - EF-hand 57889 - Cysteine-rich domain	0	DIRECT
142921,47587,56399 142921 - WGR domain-like 47587 - Domain of poly(ADP-ribose) polymerase 56399 - ADP-ribosylation	0	DIRECT
103647,103647,49899 103647 - TSP type-3 repeat 103647 - TSP type-3 repeat 49899 - Concanavalin A-like lectins/glucanases	0	DIRECT
69318,69179,69179 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains 69179 - Integrin domains	0.02876	INHERITED FROM: Aluminum Oxide || Sulfides
69179,69179,69179 69179 - Integrin domains 69179 - Integrin domains 69179 - Integrin domains	0.04455	INHERITED FROM: Aluminum Oxide || Sulfides
57196,57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin 57196 - EGF/Laminin	0.1442	INHERITED FROM: Silicon Dioxide
57196,57184,57184 57196 - EGF/Laminin 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain	0.2389	INHERITED FROM: potassium chromate(VI)
57535,57535,57535 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain 57535 - Complement control module/SCR domain	0.2921	INHERITED FROM: Arsenites
52540,90123,52540 52540 - P-loop containing nucleoside triphosphate hydrolases 90123 - ABC transporter transmembrane region 52540 - P-loop containing nucleoside triphosphate hydrolases	0.3141	INHERITED FROM: Disulfides || diallyl trisulfide || diallyl disulfide
90123,52540,90123 90123 - ABC transporter transmembrane region 52540 - P-loop containing nucleoside triphosphate hydrolases 90123 - ABC transporter transmembrane region	0.3141	INHERITED FROM: Disulfides || diallyl trisulfide || diallyl disulfide
54236,47031,50729 54236 - Ubiquitin-like 47031 - Second domain of FERM 50729 - PH domain-like	0.383	INHERITED FROM: Silicon Dioxide
47090,55486,50923 47090 - PGBD-like 55486 - Metalloproteases ("zincins"), catalytic domain 50923 - Hemopexin-like domain	0.3881	INHERITED FROM: Aluminum Oxide
52058,57184,52058 52058 - L domain-like 57184 - Growth factor receptor domain 52058 - L domain-like	0.411	INHERITED FROM: CMF regimen || Phosphoramides || Phosphates || sodium arsenite
57581,57196,57581 57581 - TB module/8-cys domain 57196 - EGF/Laminin 57581 - TB module/8-cys domain	0.411	INHERITED FROM: Cadmium Chloride
57581,57196,57196 57581 - TB module/8-cys domain 57196 - EGF/Laminin 57196 - EGF/Laminin	0.411	INHERITED FROM: Cadmium Chloride
52833,52833,52833 52833 - Thioredoxin-like 52833 - Thioredoxin-like 52833 - Thioredoxin-like	0.4352	INHERITED FROM: Chlorides || tetraarsenic tetrasulfide
57196,57196,57184 57196 - EGF/Laminin 57196 - EGF/Laminin 57184 - Growth factor receptor domain	0.4938	INHERITED FROM: potassium chromate(VI) || Arsenites
49313,49313,49313 49313 - Cadherin-like 49313 - Cadherin-like 49313 - Cadherin-like	0.5982	INHERITED FROM: Magnesium Silicates || arsenite || Asbestos, Serpentine