RUNT domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f [ 49379] (10)
• Superfamily: p53-like transcription factors [ 49417] (7)
• Family: RUNT domain [ 81318]

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Family statistics

	Genomes (143)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	491	1,392	6
Proteins	491	1,392	6

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal cell differentiation	0	1.373	--	DIRECT
Mammalian Phenotype (MP)	abnormal immune system cell morphology	0	0.8038	--	DIRECT
Mammalian Phenotype (MP)	abnormal definitive hematopoiesis	0	1.072	--	DIRECT
Mammalian Phenotype (MP)	abnormal survival	0	0.6441	--	DIRECT
Mammalian Phenotype (MP)	decreased body weight	0	1.562	--	DIRECT
Mammalian Phenotype (MP)	abnormal lung morphology	0	1.205	--	DIRECT
Mammalian Phenotype (MP)	abnormal mononuclear cell morphology	0	0.8473	--	DIRECT
Mammalian Phenotype (MP)	abnormal mononuclear phagocyte morphology	0	1.457	--	DIRECT
Mammalian Phenotype (MP)	decreased leukocyte cell number	0	1.156	--	DIRECT
Mammalian Phenotype (MP)	abnormal skeleton morphology	0	0.8323	--	DIRECT
Mammalian Phenotype (MP)	abnormal postnatal growth/weight/body size	0	0.8956	--	DIRECT
Mammalian Phenotype (MP)	abnormal respiratory system morphology	0	1.072	--	DIRECT
Mammalian Phenotype (MP)	increased leukocyte cell number	0	1.241	--	DIRECT
Mammalian Phenotype (MP)	integument phenotype	0	0.797	--	DIRECT
Mammalian Phenotype (MP)	abnormal phagocyte morphology	0	1.281	--	DIRECT
Mammalian Phenotype (MP)	abnormal myeloid leukocyte morphology	0	1.223	--	DIRECT
Mammalian Phenotype (MP)	abnormal hematopoietic cell morphology	0	0.7167	--	DIRECT
Mammalian Phenotype (MP)	abnormal hematopoietic system morphology/development	0	0.6686	--	DIRECT
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0	0.3626	--	DIRECT
Mammalian Phenotype (MP)	abnormal cell physiology	0	0.6209	--	DIRECT
Mammalian Phenotype (MP)	preweaning lethality	0	0.7055	--	DIRECT
Mammalian Phenotype (MP)	abnormal appendicular skeleton morphology	0	1.373	--	DIRECT
Mammalian Phenotype (MP)	decreased lymphocyte cell number	0	1.156	--	DIRECT
Mammalian Phenotype (MP)	abnormal hemopoiesis	0	1.072	--	DIRECT
Mammalian Phenotype (MP)	abnormal gland morphology	0	0.7519	--	DIRECT
Mammalian Phenotype (MP)	abnormal T cell number	0	1.261	--	DIRECT
Mammalian Phenotype (MP)	abnormal pectoral girdle bone morphology	0	1.758	--	DIRECT
Mammalian Phenotype (MP)	skeleton phenotype	0	0.8038	--	DIRECT
Mammalian Phenotype (MP)	abnormal leukocyte morphology	0	0.8108	--	DIRECT
Mammalian Phenotype (MP)	abnormal body weight	0	1.156	--	DIRECT
Mammalian Phenotype (MP)	abnormal respiratory system physiology	0	1.281	--	DIRECT
Mammalian Phenotype (MP)	abnormal hematopoietic cell number	0	0.8473	--	DIRECT
Mammalian Phenotype (MP)	neonatal lethality	0	1.825	--	DIRECT
Mammalian Phenotype (MP)	abnormal immune system morphology	0	0.7223	--	DIRECT
Mammalian Phenotype (MP)	abnormal leukocyte cell number	0	0.9129	--	DIRECT
Mammalian Phenotype (MP)	abnormal total tissue mass	0	1.188	--	DIRECT
Mammalian Phenotype (MP)	abnormal lymphocyte morphology	0	0.9404	--	DIRECT
Mammalian Phenotype (MP)	abnormal skeleton physiology	0	1.302	--	DIRECT
Mammalian Phenotype (MP)	immune system phenotype	0	0.5462	Least Informative	DIRECT
Mammalian Phenotype (MP)	growth/size/body region phenotype	0	0.6254	Least Informative	DIRECT
Mammalian Phenotype (MP)	mortality/aging	0	0.5424	Least Informative	DIRECT
Mammalian Phenotype (MP)	abnormal homeostasis	0	0.4926	Least Informative	DIRECT
Mammalian Phenotype (MP)	hematopoietic system phenotype	0	0.5945	Least Informative	DIRECT
Mammalian Phenotype (MP)	cellular phenotype	0	0.5387	Least Informative	DIRECT
Mammalian Phenotype (MP)	endocrine/exocrine gland phenotype	0	0.6947	Least Informative	DIRECT
Mammalian Phenotype (MP)	abnormal blood cell morphology/development	0	1.059	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal body composition	0	1.112	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal professional antigen presenting cell morphology	0	1.098	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	decreased hematopoietic cell number	0	1.072	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal T cell morphology	0	1.205	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	lethality during fetal growth through weaning	0	1.035	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	respiratory system phenotype	0	0.9404	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal lymphocyte cell number	0	1.023	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal myeloid cell morphology	0	0.9904	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	increased hematopoietic cell number	0	1.188	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal body size	0	1.001	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal axial skeleton morphology	0	1.001	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal immune system organ morphology	0	1.112	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal skin adnexa morphology	0	1.156	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal blood cell morphology	0	0.9129	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	decreased T cell number	0	1.427	Informative	DIRECT
Mammalian Phenotype (MP)	decreased body size	0	1.281	Informative	DIRECT
Mammalian Phenotype (MP)	postnatal lethality	0	1.524	Informative	DIRECT
Mammalian Phenotype (MP)	perinatal lethality	0	1.603	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal bone ossification	0	1.562	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal skeleton development	0	1.457	Informative	DIRECT
Mammalian Phenotype (MP)	decreased total tissue mass	0	1.524	Informative	DIRECT
Mammalian Phenotype (MP)	postnatal lethality, incomplete penetrance	0	1.825	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal bone mineralization	0	1.825	Highly Informative	DIRECT

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	lethal	0	0.678	--	DIRECT
Fly Phenotype (FP)	phenotype	0	0.06546	--	DIRECT
Fly Phenotype (FP)	increased mortality during development	0	0.6148	--	DIRECT
Fly Phenotype (FP)	increased mortality	0	0.5343	Least Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	cranium	0	1.693	--	DIRECT
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.1857	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1532	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: skeletal system || anatomical system || anatomical group || whole organism || organism subdivision || cranium || head
Zebrafish Anatomy (ZA)	organism subdivision	0	0.614	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	head	0	0.9398	Moderately Informative	DIRECT
Zebrafish Anatomy (ZA)	skeletal system	0	1.517	Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	ceratohyal	0	2.865	--	DIRECT
Xenopus ANatomical entity (XAN)	cartilage element	0	2.564	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	hyoid arch	0	2.865	--	DIRECT
Xenopus ANatomical entity (XAN)	lower jaw	0	2.564	--	DIRECT
Xenopus ANatomical entity (XAN)	cranium	0	1.911	--	DIRECT
Xenopus ANatomical entity (XAN)	pharyngeal arch	0	1.689	--	DIRECT
Xenopus ANatomical entity (XAN)	branchial arch	0	2.263	--	DIRECT
Xenopus ANatomical entity (XAN)	mandibular arch	0	2.564	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	Meckel's cartilage	0	2.865	--	DIRECT
Xenopus ANatomical entity (XAN)	branchial arch skeleton	0	2.865	--	DIRECT
Xenopus ANatomical entity (XAN)	skeleton	0	1.911	--	DIRECT
Xenopus ANatomical entity (XAN)	connective tissue	0	1.962	--	DIRECT
Xenopus ANatomical entity (XAN)	skeletal element	0	1.911	--	DIRECT
Xenopus ANatomical entity (XAN)	chondrocranium	0	2.865	--	DIRECT
Xenopus ANatomical entity (XAN)	head region	0	0.4759	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	skeletal subdivision	0	2.564	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	cartilage tissue	0	2.564	--	DIRECT
Xenopus ANatomical entity (XAN)	endoskeleton	0	2.564	--	DIRECT
Xenopus ANatomical entity (XAN)	primary germ layer	0	0.6748	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: splanchnocranium || Meckel's cartilage || mandibular arch || ceratohyal || lower jaw || endoskeleton || cartilage element || cranium || skeletal element || skeleton || musculoskeletal system || skeletal tissue || skeletal system || chondrocranium || cartilage tissue || branchial arch skeleton || skeletal subdivision
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: lower jaw || endoskeleton || head region || skeletal element || cranium || cartilage element || anatomical group || branchial arch || splanchnocranium || cavitated compound organ || multicellular anatomical structure || ceratohyal || mandibular arch || ectoderm || compound organ || Meckel's cartilage || tissue || anatomical region || solid compound organ || hyoid arch || chondrocranium || skeletal system || pharyngeal region || branchial arch skeleton || skeletal subdivision || connective tissue || cartilage tissue || anatomical cluster || skeletal tissue || pharyngeal arch || multi-tissue structure || neuroectoderm || musculoskeletal system || organism subdivision || skeleton || head || primary germ layer
Xenopus ANatomical entity (XAN)	tissue	0	0.4672	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	anatomical cluster	0	0.7159	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	head	0	0.4777	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.2685	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	embryo	0	0.5979	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	ectoderm	0	0.9357	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	musculoskeletal system	0	1.087	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	multi-tissue structure	0	1.066	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	pharyngeal region	0	1.467	Informative	DIRECT
Xenopus ANatomical entity (XAN)	neuroectoderm	0	1.374	Informative	DIRECT
Xenopus ANatomical entity (XAN)	skeletal system	0	1.635	Informative	DIRECT
Xenopus ANatomical entity (XAN)	solid compound organ	0	1.334	Informative	DIRECT
Xenopus ANatomical entity (XAN)	skeletal tissue	0	1.962	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	splanchnocranium	0	2.087	Highly Informative	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT
Xenopus DEvelopment stage (XDE)	embryonic stage	0	1.006	Moderately Informative	DIRECT

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