WWE domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a+b) [ 53931] (376)
• Fold: WWE domain [ 117838]
• Superfamily: WWE domain [ 117839]
• Family: WWE domain [ 117840] (2)

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Family statistics

	Genomes (118)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	213	555	3
Proteins	181	482	2

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferases	0	0	--	DIRECT
Enzyme Commission (EC)	Glycosyltransferases	0	0.993	Moderately Informative	DIRECT
Enzyme Commission (EC)	Pentosyltransferases	0	1.326	Informative	DIRECT
Enzyme Commission (EC)	NAD(+) ADP-ribosyltransferase	0	1.838	Highly Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	decreased marginal zone B cell number	0.000006073	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal marginal zone B cell morphology	0.00001862	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal spleen marginal zone morphology	0.00003629	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal B cell activation	0.00007082	1.562	--	DIRECT
Mammalian Phenotype (MP)	abnormal spleen white pulp morphology	0.0005114	1.7	--	DIRECT
Mammalian Phenotype (MP)	abnormal B cell number	0.002997	1.348	--	INHERITED FROM: abnormal mature B cell number || decreased marginal zone B cell number || decreased mature B cell number
Mammalian Phenotype (MP)	abnormal mature B cell morphology	0.003058	1.281	--	INHERITED FROM: decreased mature B cell number || decreased marginal zone B cell number || abnormal marginal zone B cell morphology || abnormal mature B cell number
Mammalian Phenotype (MP)	abnormal B cell physiology	0.003871	1.172	--	INHERITED FROM: abnormal B cell proliferation || abnormal B cell activation
Mammalian Phenotype (MP)	decreased lymphocyte cell number	0.013	1.156	--	INHERITED FROM: decreased marginal zone B cell number || decreased mature B cell number
Mammalian Phenotype (MP)	abnormal hematopoietic cell number	0.01464	0.8473	--	INHERITED FROM: decreased marginal zone B cell number || abnormal mature B cell number || decreased mature B cell number
Mammalian Phenotype (MP)	abnormal lymphocyte physiology	0.0155	1.112	--	INHERITED FROM: abnormal B cell proliferation || abnormal B cell activation
Mammalian Phenotype (MP)	abnormal immune system physiology	0.02774	0.6789	--	INHERITED FROM: abnormal B cell proliferation || abnormal B cell activation
Mammalian Phenotype (MP)	abnormal lymphocyte morphology	0.03024	0.9404	--	INHERITED FROM: abnormal mature B cell number || abnormal marginal zone B cell morphology || decreased mature B cell number || decreased marginal zone B cell number
Mammalian Phenotype (MP)	abnormal hematopoietic cell morphology	0.03465	0.7167	--	INHERITED FROM: abnormal marginal zone B cell morphology || decreased mature B cell number || decreased marginal zone B cell number || abnormal mature B cell number
Mammalian Phenotype (MP)	abnormal blood cell physiology	0.04435	0.8789	--	INHERITED FROM: abnormal B cell activation || abnormal B cell proliferation
Mammalian Phenotype (MP)	abnormal hematopoietic system morphology/development	0.05074	0.6686	--	INHERITED FROM: decreased mature B cell number || abnormal marginal zone B cell morphology || abnormal spleen marginal zone morphology || abnormal spleen white pulp morphology || abnormal mature B cell number || decreased marginal zone B cell number
Mammalian Phenotype (MP)	abnormal mononuclear cell morphology	0.05088	0.8473	--	INHERITED FROM: abnormal marginal zone B cell morphology || abnormal mature B cell number || decreased mature B cell number || decreased marginal zone B cell number
Mammalian Phenotype (MP)	abnormal immune system cell morphology	0.07438	0.8038	--	INHERITED FROM: abnormal mature B cell number || abnormal marginal zone B cell morphology || decreased mature B cell number || decreased marginal zone B cell number
Mammalian Phenotype (MP)	abnormal hematopoietic system physiology	0.1724	0.8789	--	INHERITED FROM: abnormal B cell proliferation || abnormal B cell activation
Mammalian Phenotype (MP)	abnormal immune cell physiology	0.2857	0.9219	--	INHERITED FROM: abnormal B cell proliferation || abnormal B cell activation
Mammalian Phenotype (MP)	abnormal cell-mediated immunity	0.2915	0.9219	--	INHERITED FROM: abnormal B cell proliferation || abnormal B cell activation
Mammalian Phenotype (MP)	abnormal adaptive immunity	0.3041	0.9219	--	INHERITED FROM: abnormal B cell proliferation || abnormal B cell activation
Mammalian Phenotype (MP)	decreased leukocyte cell number	0.3494	1.156	--	INHERITED FROM: decreased marginal zone B cell number || decreased mature B cell number
Mammalian Phenotype (MP)	abnormal immune system morphology	0.4113	0.7223	--	INHERITED FROM: abnormal spleen white pulp morphology || abnormal spleen marginal zone morphology || decreased mature B cell number || abnormal marginal zone B cell morphology || decreased marginal zone B cell number || abnormal mature B cell number
Mammalian Phenotype (MP)	abnormal leukocyte morphology	0.4831	0.8108	--	INHERITED FROM: decreased mature B cell number || abnormal mature B cell number || abnormal marginal zone B cell morphology || decreased marginal zone B cell number
Mammalian Phenotype (MP)	abnormal leukocyte cell number	0.5354	0.9129	--	INHERITED FROM: abnormal mature B cell number || decreased mature B cell number || decreased marginal zone B cell number
Mammalian Phenotype (MP)	hematopoietic system phenotype	0.07878	0.5945	Least Informative	INHERITED FROM: abnormal mature B cell number || abnormal B cell proliferation || decreased marginal zone B cell number || decreased mature B cell number || abnormal marginal zone B cell morphology || abnormal B cell activation || abnormal spleen marginal zone morphology || abnormal spleen white pulp morphology
Mammalian Phenotype (MP)	immune system phenotype	0.08419	0.5462	Least Informative	INHERITED FROM: decreased marginal zone B cell number || abnormal B cell proliferation || abnormal spleen marginal zone morphology || abnormal mature B cell number || abnormal spleen white pulp morphology || abnormal marginal zone B cell morphology || abnormal B cell activation || decreased mature B cell number
Mammalian Phenotype (MP)	abnormal B cell morphology	0.004167	1.156	Moderately Informative	INHERITED FROM: abnormal mature B cell number || decreased marginal zone B cell number || abnormal marginal zone B cell morphology || decreased mature B cell number
Mammalian Phenotype (MP)	decreased hematopoietic cell number	0.005645	1.072	Moderately Informative	INHERITED FROM: decreased mature B cell number || decreased marginal zone B cell number
Mammalian Phenotype (MP)	abnormal professional antigen presenting cell morphology	0.0125	1.098	Moderately Informative	INHERITED FROM: decreased mature B cell number || abnormal marginal zone B cell morphology || decreased marginal zone B cell number || abnormal mature B cell number
Mammalian Phenotype (MP)	abnormal professional antigen presenting cell physiology	0.01292	1.098	Moderately Informative	INHERITED FROM: abnormal B cell proliferation || abnormal B cell activation
Mammalian Phenotype (MP)	abnormal lymphocyte cell number	0.02414	1.023	Moderately Informative	INHERITED FROM: decreased mature B cell number || abnormal mature B cell number || decreased marginal zone B cell number
Mammalian Phenotype (MP)	abnormal immune system organ morphology	0.02622	1.112	Moderately Informative	INHERITED FROM: abnormal spleen marginal zone morphology || abnormal spleen white pulp morphology || decreased marginal zone B cell number || abnormal marginal zone B cell morphology
Mammalian Phenotype (MP)	abnormal leukocyte physiology	0.03526	0.9219	Moderately Informative	INHERITED FROM: abnormal B cell proliferation || abnormal B cell activation
Mammalian Phenotype (MP)	abnormal B cell proliferation	0.00005346	1.562	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal mature B cell number	0.0005599	1.603	Informative	DIRECT
Mammalian Phenotype (MP)	decreased B cell number	0.001341	1.562	Informative	INHERITED FROM: decreased marginal zone B cell number || decreased mature B cell number
Mammalian Phenotype (MP)	abnormal spleen morphology	0.05219	1.427	Informative	INHERITED FROM: abnormal spleen marginal zone morphology || decreased marginal zone B cell number || abnormal marginal zone B cell morphology || abnormal spleen white pulp morphology
Mammalian Phenotype (MP)	decreased mature B cell number	0.0002342	1.758	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	Q neuroblast lineage migration variant	0	1.689	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	neuron migration variant	0	1.623	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	protein aggregation variant	0.0003326	1.087	--	DIRECT
Worm Phenotype (WP)	protein interaction variant	0.0003864	1.078	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: neuron migration variant || hermaphrodite fertility variant || protein protein interaction variant || reproductive system physiology variant || cell migration variant || organism homeostasis metabolism variant || lethal || protein interaction variant || organism physiology variant || development variant || hermaphrodite sterile || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || Q neuroblast lineage migration variant || fertility variant || protein aggregation variant || postembryonic development variant || organ system physiology variant || maternal sterile || organism development variant || fertility reduced || cell development variant
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	cell development variant	0	0.6752	Least Informative	DIRECT
Worm Phenotype (WP)	organism metabolism processing variant	0.08473	0.4899	Least Informative	INHERITED FROM: protein interaction variant || protein aggregation variant || protein protein interaction variant
Worm Phenotype (WP)	protein protein interaction variant	0.000366	1.078	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell migration variant	0	1.407	Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: multicellular anatomical structure
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferases	0	0.3972	Least Informative	DIRECT
Enzyme Commission (EC)	Acyltransferases	0	1.034	Moderately Informative	DIRECT
Enzyme Commission (EC)	Aminoacyltransferases	0	1.391	Informative	DIRECT
Enzyme Commission (EC)	HECT-type E3 ubiquitin transferase	0.0001434	2.116	Highly Informative	DIRECT

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