DnaQ-like 3'-5' exonuclease family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: Ribonuclease H-like motif [ 53066] (7)
• Superfamily: Ribonuclease H-like [ 53098] (14)
• Family: DnaQ-like 3'-5' exonuclease [ 53118] (15)

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Family statistics

	Genomes (2,338)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	7,962	54,589	53
Proteins	7,959	54,576	53

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferases	0	0	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorous-containing groups	0	0.2728	--	DIRECT
Enzyme Commission (EC)	Ribonuclease D	0.0000000002352	2.44	--	DIRECT
Enzyme Commission (EC)	Exodeoxyribonuclease I	0.000000004003	2.741	--	DIRECT
Enzyme Commission (EC)	Exodeoxyribonuclease III	0.0000004062	2.44	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0.01519	0.01852	--	INHERITED FROM: Exodeoxyribonucleases producing 5'-phosphomonoeste || Exodeoxyribonuclease III || Exoribonucleases producing 5'-phosphomonoesters || Acting on ester bonds || Ribonuclease D || Exodeoxyribonuclease I || Ribonuclease H || Poly(A)-specific ribonuclease
Enzyme Commission (EC)	Nucleotidyltransferases	0	0.6958	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0	0.5107	Least Informative	DIRECT
Enzyme Commission (EC)	Exoribonucleases producing 5'-phosphomonoesters	0	1.486	Informative	DIRECT
Enzyme Commission (EC)	DNA-directed DNA polymerase	0	1.31	Informative	DIRECT
Enzyme Commission (EC)	Endoribonucleases producing 5'-phosphomonoesters	0.9952	1.361	Informative	INHERITED FROM: Ribonuclease H
Enzyme Commission (EC)	Poly(A)-specific ribonuclease	0.00000001254	2.139	Highly Informative	DIRECT
Enzyme Commission (EC)	Ribonuclease H	0.00000004468	2.042	Highly Informative	DIRECT
Enzyme Commission (EC)	Exodeoxyribonucleases producing 5'-phosphomonoeste	0.00008029	1.963	Highly Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormal large intestine morphology	0.0008866	1.763	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of skin morphology	0.01837	0.7722	--	INHERITED FROM: Telangiectasia
Phenotypic Abnormality (PA)	Abnormality of the skin	0.02579	0.722	--	INHERITED FROM: Telangiectasia
Phenotypic Abnormality (PA)	Abnormality of the vasculature	0.06858	0.7142	--	INHERITED FROM: Telangiectasia
Phenotypic Abnormality (PA)	Generalized abnormality of skin	0.3189	1.383	--	INHERITED FROM: Telangiectasia
Phenotypic Abnormality (PA)	Morphological abnormality of the gastrointestinal tract	0.3593	1.184	--	INHERITED FROM: Abnormal large intestine morphology
Phenotypic Abnormality (PA)	Abnormality of the integument	0.05646	0.6235	Least Informative	INHERITED FROM: Telangiectasia
Phenotypic Abnormality (PA)	Abnormality of the digestive system	0.07845	0.5759	Least Informative	INHERITED FROM: Abnormal large intestine morphology
Phenotypic Abnormality (PA)	Abnormality of the cardiovascular system	0.225	0.5179	Least Informative	INHERITED FROM: Telangiectasia
Phenotypic Abnormality (PA)	Abnormality of the gastrointestinal tract	0.006528	1.031	Moderately Informative	INHERITED FROM: Abnormal large intestine morphology
Phenotypic Abnormality (PA)	Abnormality of digestive system morphology	0.05201	1.184	Moderately Informative	INHERITED FROM: Abnormal large intestine morphology
Phenotypic Abnormality (PA)	Abnormality of the voice	0.0004185	1.508	Informative	DIRECT
Phenotypic Abnormality (PA)	Vascular skin abnormality	0.02776	1.462	Informative	INHERITED FROM: Telangiectasia
Phenotypic Abnormality (PA)	Abnormal intestine morphology	0.2829	1.421	Informative	INHERITED FROM: Abnormal large intestine morphology
Phenotypic Abnormality (PA)	Telangiectasia	0.0001032	2.161	Highly Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	increased thymus tumor incidence	0.0001584	1.904	--	DIRECT
Mammalian Phenotype (MP)	increased lymphoma incidence	0.002408	1.649	--	INHERITED FROM: increased T cell derived lymphoma incidence
Mammalian Phenotype (MP)	increased tumor incidence	0.01313	1.172	--	INHERITED FROM: increased T cell derived lymphoma incidence || increased sarcoma incidence || increased thymus tumor incidence
Mammalian Phenotype (MP)	abnormal tumor incidence	0.02018	1.141	--	INHERITED FROM: increased thymus tumor incidence || increased T cell derived lymphoma incidence || increased sarcoma incidence
Mammalian Phenotype (MP)	altered tumor susceptibility	0.02129	1.141	--	INHERITED FROM: increased thymus tumor incidence || increased T cell derived lymphoma incidence || increased sarcoma incidence
Mammalian Phenotype (MP)	abnormal gland morphology	0.1061	0.7519	--	INHERITED FROM: increased thymus tumor incidence || increased T cell derived lymphoma incidence
Mammalian Phenotype (MP)	abnormal classified tumor incidence	0.3914	1.324	--	INHERITED FROM: increased sarcoma incidence || increased T cell derived lymphoma incidence
Mammalian Phenotype (MP)	abnormal organ/body region tumor incidence	0.4873	1.223	--	INHERITED FROM: increased thymus tumor incidence || increased T cell derived lymphoma incidence
Mammalian Phenotype (MP)	increased classified tumor incidence	0.5306	1.324	--	INHERITED FROM: increased sarcoma incidence || increased T cell derived lymphoma incidence
Mammalian Phenotype (MP)	increased organ/body region tumor incidence	0.6249	1.223	--	INHERITED FROM: increased T cell derived lymphoma incidence || increased thymus tumor incidence
Mammalian Phenotype (MP)	endocrine/exocrine gland phenotype	0.1351	0.6947	Least Informative	INHERITED FROM: increased thymus tumor incidence || increased T cell derived lymphoma incidence
Mammalian Phenotype (MP)	neoplasm	0.02915	1.035	Moderately Informative	INHERITED FROM: increased sarcoma incidence || increased T cell derived lymphoma incidence || increased thymus tumor incidence
Mammalian Phenotype (MP)	increased hemolymphoid system tumor incidence	0.004436	1.603	Informative	INHERITED FROM: increased T cell derived lymphoma incidence
Mammalian Phenotype (MP)	increased gland tumor incidence	0.009792	1.649	Informative	INHERITED FROM: increased thymus tumor incidence || increased T cell derived lymphoma incidence
Mammalian Phenotype (MP)	increased malignant tumor incidence	0.01005	1.562	Informative	INHERITED FROM: increased sarcoma incidence
Mammalian Phenotype (MP)	increased T cell derived lymphoma incidence	0.0001522	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	increased sarcoma incidence	0.0004595	1.904	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	RNAi response variant	0.0006954	1.769	--	DIRECT
Worm Phenotype (WP)	embryonic cell physiology variant	0.002672	1.538	--	INHERITED FROM: embryonic cell organization biogenesis variant
Worm Phenotype (WP)	cell component morphology variant	0.1077	0.8392	--	INHERITED FROM: embryonic cell organization biogenesis variant
Worm Phenotype (WP)	cell morphology variant	0.2284	0.7558	--	INHERITED FROM: embryonic cell organization biogenesis variant
Worm Phenotype (WP)	organism physiology variant	0.2539	0.1342	--	INHERITED FROM: RNAi response variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: RNAi response variant || embryonic cell organization biogenesis variant || lethal || development variant || embryonic development variant || embryonic lethal || organism development variant
Worm Phenotype (WP)	organism homeostasis metabolism variant	1	0.1444	--	INHERITED FROM: RNAi response variant
Worm Phenotype (WP)	cell physiology variant	0.04312	0.5955	Least Informative	INHERITED FROM: embryonic cell organization biogenesis variant
Worm Phenotype (WP)	cell organization biogenesis variant	0.04096	1.135	Moderately Informative	INHERITED FROM: embryonic cell organization biogenesis variant
Worm Phenotype (WP)	embryonic cell organization biogenesis variant	0.0005568	1.538	Informative	DIRECT

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.09186	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0	0.1452	--	DIRECT
Yeast Phenotype (YP)	competitive fitness	0	0.1116	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1096	--	DIRECT
Yeast Phenotype (YP)	resistance to chemicals	0	0.3202	Least Informative	DIRECT
Yeast Phenotype (YP)	chromosome/plasmid maintenance	0.06273	1.444	Informative	INHERITED FROM: mutation frequency
Yeast Phenotype (YP)	mutation frequency	0.00003403	1.967	Highly Informative	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: multicellular structure || organism

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: whole organism

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	plant cell	0	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || shoot system || plant cell
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: shoot system
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || plant organ development stage

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0	0.7021	--	DIRECT
Enzyme Commission (EC)	Exodeoxyribonuclease I	0.0000000003603	3.23	--	DIRECT
Enzyme Commission (EC)	Ribonuclease D	0.0000000006231	2.929	--	DIRECT
Enzyme Commission (EC)	Ribonuclease H	0.000000003143	2.275	--	DIRECT
Enzyme Commission (EC)	Poly(A)-specific ribonuclease	0.0000001901	2.531	--	DIRECT
Enzyme Commission (EC)	Exodeoxyribonuclease III	0.0000006872	2.929	--	DIRECT
Enzyme Commission (EC)	Exodeoxyribonucleases producing 5'-phosphomonoesters	0.000006089	2.327	--	DIRECT
Enzyme Commission (EC)	Endoribonucleases producing 5'-phosphomonoesters	0.9516	1.767	--	INHERITED FROM: Ribonuclease H
Enzyme Commission (EC)	Transferases	0	0.3972	Least Informative	DIRECT
Enzyme Commission (EC)	Hydrolases	0.004738	0.4043	Least Informative	INHERITED FROM: Exodeoxyribonucleases producing 5'-phosphomonoesters || Acting on ester bonds || Poly(A)-specific ribonuclease || Exodeoxyribonuclease III || Ribonuclease H || Exoribonucleases producing 5'-phosphomonoesters || Exodeoxyribonuclease I || Ribonuclease D
Enzyme Commission (EC)	Nucleotidyltransferases	0	1.126	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0	0.8756	Moderately Informative	DIRECT
Enzyme Commission (EC)	DNA-directed DNA polymerase	0	1.725	Informative	DIRECT
Enzyme Commission (EC)	Exoribonucleases producing 5'-phosphomonoesters	0	1.951	Highly Informative	DIRECT

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