Calpain large subunit, catalytic domain (domain II) family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a+b) [ 53931] (376)
• Fold: Cysteine proteinases [ 54000]
• Superfamily: Cysteine proteinases [ 54001] (22)
• Family: Calpain large subunit, catalytic domain (domain II) [ 54040]

---

Family statistics

	Genomes (337)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	2,147	6,042	10
Proteins	2,125	6,004	10

---

Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Hydrolases	0	0.01852	--	DIRECT
Enzyme Commission (EC)	Calpain-2	0.00000000002791	2.264	--	DIRECT
Enzyme Commission (EC)	Calpain-3	0.0000000009906	2.264	--	DIRECT
Enzyme Commission (EC)	Calpain-1	0.000000002732	2.264	--	DIRECT
Enzyme Commission (EC)	Acting on peptide bonds (peptide hydrolases)	0	0.5709	Least Informative	DIRECT
Enzyme Commission (EC)	Cysteine endopeptidases	0	1.326	Informative	DIRECT

---

Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	acquired metabolic disease	0	1.191	--	DIRECT
Disease Ontology (DO)	disease of cellular proliferation	0	0.2322	--	DIRECT
Disease Ontology (DO)	cancer	0	0.2555	--	DIRECT
Disease Ontology (DO)	disease of anatomical entity	0	0.2414	--	DIRECT
Disease Ontology (DO)	muscle tissue disease	0.0001087	1.434	--	DIRECT
Disease Ontology (DO)	muscular disease	0.0001274	1.399	--	DIRECT
Disease Ontology (DO)	obesity	0.0002839	1.61	--	DIRECT
Disease Ontology (DO)	musculoskeletal system disease	0.08148	0.89	--	INHERITED FROM: muscular dystrophy || muscle tissue disease || muscular disease
Disease Ontology (DO)	nutrition disease	0.1064	1.559	--	INHERITED FROM: overnutrition || obesity
Disease Ontology (DO)	disease of metabolism	0	0.9817	Moderately Informative	DIRECT
Disease Ontology (DO)	overnutrition	0.0002989	1.559	Informative	DIRECT
Disease Ontology (DO)	myopathy	1	1.559	Informative	INHERITED FROM: muscular dystrophy
Disease Ontology (DO)	muscular dystrophy	0.000002239	1.911	Highly Informative	DIRECT

---

Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	growth variant	0	0.3438	--	DIRECT
Worm Phenotype (WP)	developmental timing variant	0	0.4548	--	DIRECT
Worm Phenotype (WP)	general pace of development variant	0	0.4786	--	DIRECT
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	retarded heterochronic variations	0	0.4548	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	larval development variant	0	0.4322	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	developmental growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	larval growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	sterile progeny	0	0.6547	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	striated muscle morphology variant	0.00005081	1.407	--	DIRECT
Worm Phenotype (WP)	muscle system morphology variant	0.00005736	1.407	--	DIRECT
Worm Phenotype (WP)	muscle cell morphology variant	0.00007966	1.337	--	DIRECT
Worm Phenotype (WP)	osmotic integrity variant	0.0001728	1.924	--	DIRECT
Worm Phenotype (WP)	metabolic pathway variant	0.001489	1.263	--	INHERITED FROM: protein degradation variant || protein metabolism variant
Worm Phenotype (WP)	cell component morphology variant	0.06011	0.8392	--	INHERITED FROM: mitochondria morphology variant
Worm Phenotype (WP)	organ system morphology variant	0.1302	0.7516	--	INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant || muscle system morphology variant
Worm Phenotype (WP)	cell morphology variant	0.1383	0.7558	--	INHERITED FROM: mitochondria morphology variant || body wall muscle sarcomere morphology variant || muscle cell morphology variant || striated muscle morphology variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || developmental growth variant || retarded heterochronic variations || larval lethal || reproductive system physiology variant || osmotic integrity variant || organism homeostasis metabolism variant || protein degradation variant || lethal || larval development variant || sterile progeny || organism physiology variant || progeny variant || slow growth || development variant || developmental timing variant || hermaphrodite sterile || growth variant || hermaphrodite fertility reduced || hypoosmotic shock hypersensitive || cell death variant || embryonic development variant || embryonic lethal || larval growth variant || general pace of development variant || fertility variant || protein metabolism variant || postembryonic development variant || larval arrest || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile || sterile progeny
Worm Phenotype (WP)	body wall muscle morphology variant	1	1.446	--	INHERITED FROM: body wall muscle sarcomere morphology variant
Worm Phenotype (WP)	slow growth	0	0.4945	Least Informative	DIRECT
Worm Phenotype (WP)	larval lethal	0	0.5727	Least Informative	DIRECT
Worm Phenotype (WP)	larval arrest	0	0.4991	Least Informative	DIRECT
Worm Phenotype (WP)	progeny variant	0	0.6514	Least Informative	DIRECT
Worm Phenotype (WP)	cell physiology variant	0.1416	0.5955	Least Informative	INHERITED FROM: protein degradation variant || cell death variant || protein metabolism variant
Worm Phenotype (WP)	organism metabolism processing variant	0.6591	0.4899	Least Informative	INHERITED FROM: protein degradation variant || protein metabolism variant
Worm Phenotype (WP)	cell death variant	0.0003246	1.061	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell homeostasis metabolism variant	0.01718	1.036	Moderately Informative	INHERITED FROM: protein metabolism variant || protein degradation variant
Worm Phenotype (WP)	cell type morphology variant	0.0433	0.8878	Moderately Informative	INHERITED FROM: striated muscle morphology variant || body wall muscle sarcomere morphology variant || muscle cell morphology variant
Worm Phenotype (WP)	mitochondria morphology variant	0.00002087	1.513	Informative	DIRECT
Worm Phenotype (WP)	body wall muscle sarcomere morphology variant	0.00003482	1.446	Informative	DIRECT
Worm Phenotype (WP)	protein metabolism variant	0.0002941	1.354	Informative	DIRECT
Worm Phenotype (WP)	hypoosmotic shock hypersensitive	0.0000001219	2.07	Highly Informative	DIRECT
Worm Phenotype (WP)	protein degradation variant	0.000001587	1.866	Highly Informative	DIRECT

---

Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.06546	--	DIRECT
Fly Phenotype (FP)	viable	0	0.6613	Least Informative	DIRECT
Fly Phenotype (FP)	behavior defective	0	1.306	Informative	DIRECT

---

Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1532	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: anatomical group || whole organism

---

Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

---

Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Cysteine endopeptidases	0	1.753	--	DIRECT
Enzyme Commission (EC)	Calpain-2	0.00000000003324	2.753	--	DIRECT
Enzyme Commission (EC)	Calpain-3	0.00000000115	2.753	--	DIRECT
Enzyme Commission (EC)	Calpain-1	0.000000003167	2.753	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.4043	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on peptide bonds (peptidases)	0	1.004	Moderately Informative	DIRECT

---