RING finger domain, C3HC4 family

SCOP classification

Root:	SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:	Small proteins [ 56992] (90)
Fold:	RING/U-box [ 57849]
Superfamily:	RING/U-box [ 57850] (6)
Family:	RING finger domain, C3HC4 [ 57851] (14)

Family statistics

	Genomes (473)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	2,236	14,724	14
Proteins	2,236	14,711	14

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Glycosyltransferases	0	Moderately Informative	Direct
Enzyme Commission (EC)	Hexosyltransferases	0	Informative	Direct

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)

	HP term	FDR (all)	SDHP level	Annotation (direct or inherited)
Mode of Inheritance (MI)	Somatic mutation	0.0003445	Moderately Informative	Direct
Phenotypic Abnormality (PA)	Abnormality of the genitourinary system	0.09462	Least Informative	Inherited
Phenotypic Abnormality (PA)	Abnormal reproductive system morphology	0.001834	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Neoplasm	0.1171	Moderately Informative	Inherited
Phenotypic Abnormality (PA)	Breast carcinoma	0.0002374	Highly Informative	Direct
Phenotypic Abnormality (PA)	Prostate neoplasm	0.0002899	Highly Informative	Direct

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)

	MP term	FDR (all)	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	cellular phenotype	0.2909	Least Informative	Inherited
Mammalian Phenotype (MP)	immune system phenotype	0.4183	Least Informative	Inherited
Mammalian Phenotype (MP)	abnormal inflammatory response	0.3435	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal immune serum protein physiology	0.4235	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal skin physiology	0.05592	Informative	Inherited
Mammalian Phenotype (MP)	increased interleukin-2 secretion	0.0005486	Highly Informative	Direct
Mammalian Phenotype (MP)	chromosomal instability	0.0007324	Highly Informative	Direct

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)

	WP term	FDR (all)	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	cell development variant	0.000000008661	Least Informative	Direct
Worm Phenotype (WP)	organism metabolism processing variant	0.0002224	Least Informative	Direct
Worm Phenotype (WP)	organism environmental stimulus response variant	0.2813	Least Informative	Inherited
Worm Phenotype (WP)	cell physiology variant	0.3436	Least Informative	Inherited
Worm Phenotype (WP)	protein protein interaction variant	0	Moderately Informative	Direct
Worm Phenotype (WP)	pattern of transgene expression variant	0.00000001054	Moderately Informative	Direct
Worm Phenotype (WP)	cell homeostasis metabolism variant	0.004086	Moderately Informative	Inherited
Worm Phenotype (WP)	organism stress response variant	0.06108	Moderately Informative	Inherited
Worm Phenotype (WP)	cell migration variant	0	Informative	Direct
Worm Phenotype (WP)	cell stress response variant	0.03101	Informative	Inherited
Worm Phenotype (WP)	germ cell physiology variant	0.09092	Informative	Inherited
Worm Phenotype (WP)	cell ionizing radiation response variant	0.01113	Highly Informative	Inherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)

	FP term	FDR (all)	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	fertile	0.0003186	Moderately Informative	Direct

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)

	AP term	FDR (all)	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	trichome	0.00008578	Highly Informative	Direct

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferases	0	Least Informative	Direct
Enzyme Commission (EC)	Acyltransferases	0	Moderately Informative	Direct
Enzyme Commission (EC)	Aminoacyltransferases	0	Informative	Direct
Enzyme Commission (EC)	Glycosyltransferases	1	Informative	Inherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links


Superfamily level	Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Superfamily level	Family level

Alignments of sequences to 38 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a RING/U-box domain.


Superfamily level	Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

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RING finger domain, C3HC4 family