Skp1 dimerisation domain-like family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All alpha proteins [ 46456] (284)
• Fold: Skp1 dimerisation domain-like [ 81384]
• Superfamily: Skp1 dimerisation domain-like [ 81382]
• Family: Skp1 dimerisation domain-like [ 81380] (2)

---

Family statistics

	Genomes (468)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	1,019	2,481	5
Proteins	1,019	2,471	5

---

Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	growth variant	0	0.3438	--	DIRECT
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	body morphology variant	0	1.145	--	DIRECT
Worm Phenotype (WP)	L1 arrest	0	2.468	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	cell proliferation variant	0	1.99	--	DIRECT
Worm Phenotype (WP)	oogenesis variant	0	1.237	--	DIRECT
Worm Phenotype (WP)	accumulated cell corpses	0	1.371	--	DIRECT
Worm Phenotype (WP)	meiotic progression during oogenesis variant	0	1.321	--	DIRECT
Worm Phenotype (WP)	cytoplasmic streaming defective	0	2.292	--	DIRECT
Worm Phenotype (WP)	Q neuroblast lineage migration variant	0	1.689	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	body axis morphology variant	0	2.292	--	DIRECT
Worm Phenotype (WP)	cell corpse number variant	0	1.306	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	larval development variant	0	0.4322	--	DIRECT
Worm Phenotype (WP)	L1 larval development variant	0	2.292	--	DIRECT
Worm Phenotype (WP)	spindle defective early emb	0	1.727	--	DIRECT
Worm Phenotype (WP)	spindle position defective early emb	0	2.468	--	DIRECT
Worm Phenotype (WP)	meiosis variant	0	1.263	--	DIRECT
Worm Phenotype (WP)	late embryonic arrest	0	2.292	--	DIRECT
Worm Phenotype (WP)	posterior body morphology variant	0	2.468	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	developmental growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	larval growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	cytoplasmic dynamics defective early emb	0	2.292	--	DIRECT
Worm Phenotype (WP)	excessive blebbing early emb	0	2.292	--	DIRECT
Worm Phenotype (WP)	mitotic spindle defective early emb	0	1.814	--	DIRECT
Worm Phenotype (WP)	neuron migration variant	0	1.623	--	DIRECT
Worm Phenotype (WP)	polar body defective early emb	0	2.468	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	organelle organization biogenesis variant	0	1.306	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	cytoplasmic appearance variant	0	1.99	--	DIRECT
Worm Phenotype (WP)	microtubule organization biogenesis variant	0	1.727	--	DIRECT
Worm Phenotype (WP)	meiotic progression prophase variant	0	1.407	--	DIRECT
Worm Phenotype (WP)	univalent meiotic chromosomes	0	2.468	--	DIRECT
Worm Phenotype (WP)	spindle variant	0	1.727	--	DIRECT
Worm Phenotype (WP)	spindle position variant	0	2.468	--	DIRECT
Worm Phenotype (WP)	apoptosis variant	0.00000000000009845	1.125	--	DIRECT
Worm Phenotype (WP)	embryonic cell physiology variant	0.000000000000198	1.538	--	DIRECT
Worm Phenotype (WP)	programmed cell death variant	0.000000000000259	1.087	--	DIRECT
Worm Phenotype (WP)	cell component morphology variant	0.0000000009924	0.8392	--	DIRECT
Worm Phenotype (WP)	resistant to protein aggregation induced paralysis	0.00000000102	2.292	--	DIRECT
Worm Phenotype (WP)	cell morphology variant	0.00000003109	0.7558	--	DIRECT
Worm Phenotype (WP)	protein aggregation induced behavior variant	0.00000003382	1.769	--	DIRECT
Worm Phenotype (WP)	aneuploidy	0.00001775	2.167	--	DIRECT
Worm Phenotype (WP)	meiotic chromosome segregation variant	0.00002946	2.167	--	DIRECT
Worm Phenotype (WP)	chromosome segregation variant	0.001153	1.814	--	INHERITED FROM: aneuploidy || meiotic chromosome segregation variant || X chromosome nondisjunction
Worm Phenotype (WP)	gametogenesis variant	0.002954	1.013	--	INHERITED FROM: germ cell differentiation variant || pachytene progression during oogenesis variant || meiotic progression prophase variant || univalent meiotic chromosomes || oogenesis variant || meiotic chromosome organization variant || X chromosome nondisjunction || germ cell development variant || meiotic progression during oogenesis variant || meiosis variant
Worm Phenotype (WP)	protein aggregation variant	0.03175	1.087	--	INHERITED FROM: protein aggregation induced behavior variant || resistant to protein aggregation induced paralysis
Worm Phenotype (WP)	protein interaction variant	0.03741	1.078	--	INHERITED FROM: protein aggregation induced behavior variant || resistant to protein aggregation induced paralysis
Worm Phenotype (WP)	chromosome disjunction defective	0.8078	2.167	--	INHERITED FROM: X chromosome nondisjunction
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: cell corpse number variant || neuron migration variant || hermaphrodite fertility variant || meiotic progression during oogenesis variant || developmental growth variant || X chromosome nondisjunction || spindle variant || reproductive system physiology variant || cell migration variant || cytoplasmic appearance defective early emb || early embryonic lethal || embryonic cell organization biogenesis variant || chemical response variant || oogenesis variant || L1 arrest || organism homeostasis metabolism variant || early larval arrest || cytoplasmic dynamics defective early emb || apoptosis variant || lethal || larval development variant || excessive blebbing early emb || meiotic chromosome organization variant || spindle defective early emb || organism physiology variant || meiosis variant || germ cell development variant || germ cell differentiation variant || embryonic cell physiology variant || mitotic spindle defective early emb || resistant to protein aggregation induced paralysis || cell division variant || cytoplasmic streaming defective || protein aggregation induced behavior variant || cell proliferation increased || development variant || accumulated germline cell corpses || late embryonic arrest || apoptosis increased || cell physiology variant || hermaphrodite sterile || polar body defective early emb || organism environmental stimulus response variant || growth variant || spindle position orientation defective early emb || hermaphrodite fertility reduced || cell death variant || univalent meiotic chromosomes || accumulated cell corpses || embryonic development variant || embryonic lethal || Q neuroblast lineage migration variant || spindle position variant || larval growth variant || fertility variant || embryonic arrest || cell proliferation variant || microtubule organization biogenesis variant || cell cycle variant || pachytene progression during oogenesis variant || meiotic progression prophase variant || postembryonic development variant || L1 larval development variant || larval arrest || meiotic chromosome segregation variant || organ system physiology variant || chemical hypersensitive || maternal sterile || organism development variant || programmed cell death variant || aneuploidy || spindle position defective early emb || fertility reduced || cell development variant
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	larval arrest	0	0.4991	Least Informative	DIRECT
Worm Phenotype (WP)	cell development variant	0	0.6752	Least Informative	DIRECT
Worm Phenotype (WP)	cell physiology variant	0.00000000008564	0.5955	Least Informative	DIRECT
Worm Phenotype (WP)	organism environmental stimulus response variant	0.00003664	0.6614	Least Informative	DIRECT
Worm Phenotype (WP)	organism metabolism processing variant	0.9255	0.4899	Least Informative	INHERITED FROM: protein aggregation induced behavior variant || resistant to protein aggregation induced paralysis
Worm Phenotype (WP)	body region morphology variant	0	1.087	Moderately Informative	DIRECT
Worm Phenotype (WP)	organism segment morphology variant	0	1.087	Moderately Informative	DIRECT
Worm Phenotype (WP)	germ cell differentiation variant	6.263e-16	1.167	Moderately Informative	DIRECT
Worm Phenotype (WP)	early embryonic lethal	0.000000000000002504	1.178	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell organization biogenesis variant	0.000000000000004067	1.135	Moderately Informative	DIRECT
Worm Phenotype (WP)	germ cell development variant	0.0000000000006288	1.013	Moderately Informative	DIRECT
Worm Phenotype (WP)	chemical response variant	0.000000001677	0.9053	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell cycle variant	0.00000005216	1.225	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell death variant	0.00001154	1.061	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell division variant	0.00001608	1.036	Moderately Informative	DIRECT
Worm Phenotype (WP)	protein protein interaction variant	0.03524	1.078	Moderately Informative	INHERITED FROM: resistant to protein aggregation induced paralysis || protein aggregation induced behavior variant
Worm Phenotype (WP)	cell homeostasis metabolism variant	1	1.036	Moderately Informative	INHERITED FROM: meiotic chromosome segregation variant || aneuploidy || X chromosome nondisjunction
Worm Phenotype (WP)	embryonic cell organization biogenesis variant	0	1.538	Informative	DIRECT
Worm Phenotype (WP)	accumulated germline cell corpses	0	1.513	Informative	DIRECT
Worm Phenotype (WP)	cytoskeleton organization biogenesis variant	0	1.623	Informative	DIRECT
Worm Phenotype (WP)	chemical hypersensitive	0	1.388	Informative	DIRECT
Worm Phenotype (WP)	pachytene progression during oogenesis variant	0	1.565	Informative	DIRECT
Worm Phenotype (WP)	meiotic chromosome organization variant	0	1.623	Informative	DIRECT
Worm Phenotype (WP)	cell migration variant	0.0000000005097	1.407	Informative	DIRECT
Worm Phenotype (WP)	early larval arrest	0	1.866	Highly Informative	DIRECT
Worm Phenotype (WP)	cell proliferation increased	0	1.99	Highly Informative	DIRECT
Worm Phenotype (WP)	apoptosis increased	0	1.866	Highly Informative	DIRECT
Worm Phenotype (WP)	spindle position orientation defective early emb	0	2.167	Highly Informative	DIRECT
Worm Phenotype (WP)	cytoplasmic appearance defective early emb	0	1.99	Highly Informative	DIRECT
Worm Phenotype (WP)	embryonic arrest	0	1.924	Highly Informative	DIRECT
Worm Phenotype (WP)	X chromosome nondisjunction	0.00001311	2.167	Highly Informative	DIRECT
Worm Phenotype (WP)	protein aggregation induced paralysis	1	2.167	Highly Informative	INHERITED FROM: resistant to protein aggregation induced paralysis

---

Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.06546	--	DIRECT

---

Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	valve	0	2.424	--	DIRECT
Plant ANatomical entity (PAN)	seed coat	0.0000000003256	2.6	--	DIRECT
Plant ANatomical entity (PAN)	fruit valve	0.000000008955	2.424	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0.479	0.2335	--	INHERITED FROM: fruit valve || fruit || primary root || valve || seed coat
Plant ANatomical entity (PAN)	portion of plant tissue	1	0.1621	--	INHERITED FROM: seed coat
Plant ANatomical entity (PAN)	plant organ	1	0.2391	--	INHERITED FROM: fruit valve || valve || primary root
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: fruit valve || primary root || seed coat || fruit || valve
Plant ANatomical entity (PAN)	cardinal organ part	1	0.4385	--	INHERITED FROM: fruit valve || valve
Plant ANatomical entity (PAN)	plant axis	1	0.3257	--	INHERITED FROM: primary root
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: primary root
Plant ANatomical entity (PAN)	root system	1	0.4584	--	INHERITED FROM: primary root
Plant ANatomical entity (PAN)	collective plant structure	1	0.01555	--	INHERITED FROM: primary root
Plant ANatomical entity (PAN)	cardinal part of multi-tissue plant structure	1	0.437	--	INHERITED FROM: valve || fruit valve
Plant ANatomical entity (PAN)	root	1	0.4679	Least Informative	INHERITED FROM: primary root
Plant ANatomical entity (PAN)	seed	1	0.5189	Least Informative	INHERITED FROM: seed coat
Plant ANatomical entity (PAN)	fruit	0	1.345	Informative	DIRECT
Plant ANatomical entity (PAN)	primary root	0.00005474	2.123	Highly Informative	DIRECT
Plant structure DEvelopment stage (PDE)	whole plant development stage	1	0.1547	--	INHERITED FROM: seedling development stage
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	1	0.1593	--	INHERITED FROM: seedling development stage
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.1584	--	INHERITED FROM: seedling development stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.1584	--	INHERITED FROM: seedling development stage
Plant structure DEvelopment stage (PDE)	seedling development stage	0.000001001	1.721	Informative	DIRECT

---