| 148 | 135 | 34 | 6 | SCOP 52540 | P-loop containing nucleoside triphosphate hydrolases |
| 52 | 52 | 15 | 2 | SCOP 46785 | "Winged helix" DNA-binding domain |
| 47 | 47 | 14 | 8 | SCOP 51735 | NAD(P)-binding Rossmann-fold domains |
| 34 | 28 | 10 | 1 | SCOP 51905 | FAD/NAD(P)-binding domain |
| 29 | 29 | 6 | 5 | SCOP 53335 | S-adenosyl-L-methionine-dependent methyltransferases |
| 27 | 26 | 4 | 0 | SCOP 103473 | MFS general substrate transporter |
| 26 | 25 | 9 | 0 | SCOP 54862 | 4Fe-4S ferredoxins |
| 23 | 23 | 10 | 3 | SCOP 50249 | Nucleic acid-binding proteins |
| 23 | 23 | 5 | 0 | SCOP 102114 | Radical SAM enzymes |
| 22 | 22 | 4 | 0 | SCOP 53448 | Nucleotide-diphospho-sugar transferases |
| 18 | 18 | 8 | 2 | SCOP 52402 | Adenine nucleotide alpha hydrolases-like |
| 18 | 13 | 4 | 1 | SCOP 54631 | CBS-domain pair |
| 17 | 14 | 5 | 1 | SCOP 161098 | MetI-like |
| 17 | 16 | 9 | 1 | SCOP 53850 | Periplasmic binding protein-like II |
| 16 | 14 | 5 | 3 | SCOP 52518 | Thiamin diphosphate-binding fold (THDP-binding) |
| 16 | 16 | 3 | 1 | SCOP 56281 | Metallo-hydrolase/oxidoreductase |
| 16 | 8 | 1 | 1 | SCOP 53901 | Thiolase-like |
| 15 | 15 | 2 | 1 | SCOP 53756 | UDP-Glycosyltransferase/glycogen phosphorylase |
| 14 | 13 | 9 | 5 | SCOP 56059 | Glutathione synthetase ATP-binding domain-like |
| 14 | 14 | 9 | 3 | SCOP 52374 | Nucleotidylyl transferase |
| 13 | 13 | 2 | 3 | SCOP 53383 | PLP-dependent transferases |
| 13 | 12 | 8 | 2 | SCOP 54211 | Ribosomal protein S5 domain 2-like |
| 12 | 11 | 6 | 1 | SCOP 52833 | Thioredoxin-like |
| 12 | 12 | 10 | 1 | SCOP 55681 | Class II aaRS and biotin synthetases |
| 12 | 12 | 5 | 4 | SCOP 56235 | N-terminal nucleophile aminohydrolases (Ntn hydrolases) |
| 12 | 7 | 2 | 0 | SCOP 103481 | Multidrug resistance efflux transporter EmrE |
| 11 | 11 | 4 | 2 | SCOP 52317 | Class I glutamine amidotransferase-like |
| 11 | 11 | 3 | 0 | SCOP 56784 | HAD-like |
| 10 | 10 | 5 | 3 | SCOP 51569 | Aldolase |
| 10 | 9 | 6 | 1 | SCOP 53271 | PRTase-like |
| 10 | 10 | 4 | 0 | SCOP 55729 | Acyl-CoA N-acyltransferases (Nat) |
| 10 | 10 | 9 | 2 | SCOP 50447 | Translation proteins |
| 10 | 9 | 3 | 1 | SCOP 48179 | 6-phosphogluconate dehydrogenase C-terminal domain-like |
| 9 | 9 | 2 | 4 | SCOP 51366 | Ribulose-phoshate binding barrel |
| 8 | 8 | 1 | 1 | SCOP 53790 | Tetrapyrrole methylase |
| 8 | 7 | 5 | 3 | SCOP 100950 | NagB/RpiA/CoA transferase-like |
| 8 | 8 | 2 | 1 | SCOP 53686 | Tryptophan synthase beta subunit-like PLP-dependent enzymes |
| 8 | 8 | 5 | 3 | SCOP 51621 | Phosphoenolpyruvate/pyruvate domain |
| 8 | 8 | 2 | 1 | SCOP 56801 | Acetyl-CoA synthetase-like |
| 8 | 8 | 2 | 2 | SCOP 51998 | PFL-like glycyl radical enzymes |
| 8 | 8 | 2 | 0 | SCOP 81301 | Nucleotidyltransferase |
| 8 | 7 | 4 | 1 | SCOP 52440 | PreATP-grasp domain |
| 7 | 7 | 3 | 0 | SCOP 56300 | Metallo-dependent phosphatases |
| 7 | 7 | 1 | 1 | SCOP 52980 | Restriction endonuclease-like |
| 7 | 7 | 2 | 0 | SCOP 75169 | DsrEFH-like |
| 7 | 7 | 6 | 0 | SCOP 50692 | ADC-like |
| 7 | 7 | 7 | 0 | SCOP 88697 | PUA domain-like |
| 7 | 7 | 5 | 0 | SCOP 46548 | alpha-helical ferredoxin |
| 7 | 7 | 3 | 0 | SCOP 52922 | TK C-terminal domain-like |
| 7 | 7 | 1 | 1 | SCOP 55347 | Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain |
| 7 | 6 | 3 | 1 | SCOP 56042 | PurM C-terminal domain-like |
| 6 | 6 | 1 | 0 | SCOP 57829 | Zn-binding ribosomal proteins |
| 6 | 6 | 4 | 3 | SCOP 50104 | Translation proteins SH3-like domain |
| 6 | 6 | 1 | 1 | SCOP 55811 | Nudix |
| 6 | 5 | 2 | 0 | SCOP 54637 | Thioesterase/thiol ester dehydrase-isomerase |
| 6 | 5 | 3 | 1 | SCOP 51395 | FMN-linked oxidoreductases |
| 6 | 6 | 1 | 0 | SCOP 64307 | SirA-like |
| 6 | 6 | 3 | 1 | SCOP 53187 | Zn-dependent exopeptidases |
| 6 | 6 | 3 | 1 | SCOP 50182 | Sm-like ribonucleoproteins |
| 6 | 6 | 3 | 1 | SCOP 109604 | HD-domain/PDEase-like |
| 6 | 6 | 4 | 3 | SCOP 52467 | DHS-like NAD/FAD-binding domain |
| 6 | 6 | 3 | 0 | SCOP 53323 | Pyruvate-ferredoxin oxidoreductase, PFOR, domain III |
| 6 | 6 | 6 | 0 | SCOP 55021 | ACT-like |
| 6 | 6 | 6 | 1 | SCOP 47323 | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases |
| 6 | 6 | 1 | 0 | SCOP 56014 | Nitrite and sulphite reductase 4Fe-4S domain-like |
| 6 | 4 | 3 | 1 | SCOP 52210 | Succinyl-CoA synthetase domains |
| 6 | 5 | 2 | 1 | SCOP 55326 | PurM N-terminal domain-like |
| 6 | 4 | 3 | 0 | SCOP 47954 | Cyclin-like |
| 6 | 6 | 1 | 0 | SCOP 55124 | Nitrite/Sulfite reductase N-terminal domain-like |
| 5 | 5 | 3 | 1 | SCOP 51556 | Metallo-dependent hydrolases |
| 5 | 5 | 3 | 3 | SCOP 53613 | Ribokinase-like |
| 5 | 5 | 3 | 0 | SCOP 56112 | Protein kinase-like (PK-like) |
| 5 | 5 | 2 | 3 | SCOP 53633 | Carbamate kinase-like |
| 5 | 5 | 4 | 1 | SCOP 52096 | ClpP/crotonase |
| 5 | 5 | 3 | 1 | SCOP 88723 | PIN domain-like |
| 5 | 5 | 5 | 1 | SCOP 52954 | Class II aaRS ABD-related |
| 5 | 5 | 2 | 0 | SCOP 47598 | Ribbon-helix-helix |
| 5 | 5 | 5 | 0 | SCOP 47413 | lambda repressor-like DNA-binding domains |
| 5 | 5 | 4 | 0 | SCOP 57783 | Zinc beta-ribbon |
| 5 | 5 | 1 | 1 | SCOP 53807 | "Helical backbone" metal receptor |
| 5 | 5 | 5 | 2 | SCOP 53218 | Molybdenum cofactor biosynthesis proteins |
| 5 | 5 | 2 | 0 | SCOP 53822 | Periplasmic binding protein-like I |
| 5 | 5 | 1 | 1 | SCOP 56645 | Acyl-CoA dehydrogenase NM domain-like |
| 5 | 5 | 1 | 1 | SCOP 89796 | CoA-transferase family III (CaiB/BaiF) |
| 5 | 5 | 1 | 1 | SCOP 47203 | Acyl-CoA dehydrogenase C-terminal domain-like |
| 5 | 5 | 5 | 1 | SCOP 53706 | Formate dehydrogenase/DMSO reductase, domains 1-3 |
| 5 | 5 | 1 | 2 | SCOP 53223 | Aminoacid dehydrogenase-like, N-terminal domain |
| 4 | 4 | 1 | 1 | SCOP 54189 | Ribosomal proteins S24e, L23 and L15e |
| 4 | 4 | 1 | 2 | SCOP 55282 | RL5-like |
| 4 | 4 | 4 | 1 | SCOP 53137 | Translational machinery components |
| 4 | 4 | 4 | 1 | SCOP 55120 | Pseudouridine synthase |
| 4 | 4 | 2 | 0 | SCOP 64182 | DHH phosphoesterases |
| 4 | 4 | 2 | 0 | SCOP 53067 | Actin-like ATPase domain |
| 4 | 4 | 2 | 0 | SCOP 89447 | AbrB/MazE/MraZ-like |
| 4 | 4 | 2 | 0 | SCOP 47240 | Ferritin-like |
| 4 | 4 | 2 | 2 | SCOP 53098 | Ribonuclease H-like |
| 4 | 4 | 2 | 0 | SCOP 75217 | alpha/beta knot |
| 4 | 4 | 3 | 1 | SCOP 55486 | Metalloproteases ("zincins"), catalytic domain |
| 4 | 4 | 1 | 1 | SCOP 50129 | GroES-like |
| 4 | 4 | 3 | 0 | SCOP 51161 | Trimeric LpxA-like enzymes |
| 4 | 4 | 1 | 2 | SCOP 53720 | ALDH-like |
| 4 | 4 | 2 | 1 | SCOP 48150 | DNA-glycosylase |
| 4 | 4 | 4 | 0 | SCOP 54292 | 2Fe-2S ferredoxin-like |
| 4 | 4 | 2 | 0 | SCOP 54285 | MoaD/ThiS |
| 4 | 4 | 1 | 1 | SCOP 51430 | NAD(P)-linked oxidoreductase |
| 4 | 4 | 3 | 1 | SCOP 55315 | L30e-like |
| 4 | 3 | 3 | 0 | SCOP 51126 | Pectin lyase-like |
| 4 | 4 | 3 | 0 | SCOP 88713 | Glycoside hydrolase/deacetylase |
| 4 | 4 | 1 | 2 | SCOP 52283 | Formate/glycerate dehydrogenase catalytic domain-like |
| 4 | 4 | 3 | 0 | SCOP 54909 | Dimeric alpha+beta barrel |
| 4 | 4 | 3 | 1 | SCOP 52016 | LeuD/IlvD-like |
| 4 | 4 | 3 | 0 | SCOP 54975 | Acylphosphatase/BLUF domain-like |
| 4 | 3 | 3 | 0 | SCOP 54814 | Prokaryotic type KH domain (KH-domain type II) |
| 4 | 4 | 1 | 1 | SCOP 81593 | Nucleotidyltransferase substrate binding subunit/domain |
| 4 | 4 | 3 | 0 | SCOP 103501 | Respiratory nitrate reductase 1 gamma chain |
| 4 | 4 | 3 | 0 | SCOP 143437 | THUMP domain-like |
| 4 | 4 | 2 | 0 | SCOP 55424 | FAD/NAD-linked reductases, dimerisation (C-terminal) domain |
| 4 | 2 | 1 | 0 | SCOP 55979 | DNA clamp |
| 4 | 4 | 2 | 1 | SCOP 56425 | Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain |
| 4 | 4 | 2 | 1 | SCOP 46977 | Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain |
| 4 | 4 | 2 | 1 | SCOP 48310 | Aldehyde ferredoxin oxidoreductase, C-terminal domains |
| 4 | 4 | 2 | 1 | SCOP 56228 | Aldehyde ferredoxin oxidoreductase, N-terminal domain |
| 3 | 3 | 2 | 0 | SCOP 53474 | alpha/beta-Hydrolases |
| 3 | 3 | 1 | 1 | SCOP 53167 | Purine and uridine phosphorylases |
| 3 | 3 | 2 | 2 | SCOP 53697 | SIS domain |
| 3 | 3 | 1 | 0 | SCOP 54197 | HIT-like |
| 3 | 3 | 2 | 0 | SCOP 57716 | Glucocorticoid receptor-like (DNA-binding domain) |
| 3 | 3 | 2 | 1 | SCOP 55920 | Creatinase/aminopeptidase |
| 3 | 3 | 1 | 0 | SCOP 109755 | PhoU-like |
| 3 | 3 | 1 | 2 | SCOP 64484 | beta and beta-prime subunits of DNA dependent RNA-polymerase |
| 3 | 3 | 1 | 1 | SCOP 48557 | L-aspartase-like |
| 3 | 3 | 3 | 2 | SCOP 55821 | YrdC/RibB |
| 3 | 3 | 2 | 1 | SCOP 56770 | HydA/Nqo6-like |
| 3 | 2 | 2 | 2 | SCOP 55205 | EPT/RTPC-like |
| 3 | 3 | 1 | 1 | SCOP 81345 | ABC transporter involved in vitamin B12 uptake, BtuC |
| 3 | 3 | 1 | 1 | SCOP 69721 | DsrC, the gamma subunit of dissimilatory sulfite reductase |
| 3 | 3 | 2 | 0 | SCOP 49764 | HSP20-like chaperones |
| 3 | 3 | 3 | 1 | SCOP 50475 | FMN-binding split barrel |
| 3 | 3 | 2 | 1 | SCOP 56672 | DNA/RNA polymerases |
| 3 | 3 | 1 | 0 | SCOP 53649 | Alkaline phosphatase-like |
| 3 | 3 | 3 | 1 | SCOP 51445 | (Trans)glycosidases |
| 3 | 3 | 2 | 0 | SCOP 57997 | Tropomyosin |
| 3 | 3 | 2 | 1 | SCOP 51182 | RmlC-like cupins |
| 3 | 3 | 3 | 2 | SCOP 53639 | AraD/HMP-PK domain-like |
| 3 | 3 | 1 | 1 | SCOP 52768 | Arginase/deacetylase |
| 3 | 3 | 1 | 1 | SCOP 55620 | Tetrahydrobiopterin biosynthesis enzymes-like |
| 3 | 3 | 3 | 1 | SCOP 81342 | Transmembrane di-heme cytochromes |
| 3 | 2 | 2 | 0 | SCOP 46955 | Putative DNA-binding domain |
| 3 | 3 | 1 | 0 | SCOP 53300 | vWA-like |
| 3 | 3 | 2 | 1 | SCOP 54913 | GlnB-like |
| 3 | 3 | 2 | 2 | SCOP 56762 | HydB/Nqo4-like |
| 3 | 3 | 1 | 0 | SCOP 89028 | Cobalamin adenosyltransferase-like |
| 3 | 3 | 1 | 1 | SCOP 50331 | MOP-like |
| 3 | 2 | 2 | 0 | SCOP 56024 | Phospholipase D/nuclease |
| 3 | 3 | 2 | 1 | SCOP 50465 | EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain |
| 3 | 3 | 1 | 1 | SCOP 51690 | Nicotinate/Quinolinate PRTase C-terminal domain-like |
| 3 | 3 | 2 | 1 | SCOP 56176 | FAD-binding/transporter-associated domain-like |
| 3 | 2 | 2 | 0 | SCOP 54980 | EF-G C-terminal domain-like |
| 3 | 3 | 1 | 0 | SCOP 51971 | Nucleotide-binding domain |
| 3 | 3 | 3 | 1 | SCOP 63882 | MoeA N-terminal region -like |
| 3 | 3 | 3 | 1 | SCOP 50677 | ValRS/IleRS/LeuRS editing domain |
| 3 | 1 | 1 | 0 | SCOP 53738 | Phosphoglucomutase, first 3 domains |
| 3 | 3 | 1 | 0 | SCOP 55031 | Bacterial exopeptidase dimerisation domain |
| 3 | 3 | 1 | 0 | SCOP 54675 | Nicotinate/Quinolinate PRTase N-terminal domain-like |
| 2 | 2 | 1 | 1 | SCOP 53927 | Cytidine deaminase-like |
| 2 | 2 | 1 | 1 | SCOP 52141 | Uracil-DNA glycosylase-like |
| 2 | 2 | 2 | 0 | SCOP 111331 | NAD kinase/diacylglycerol kinase-like |
| 2 | 2 | 1 | 0 | SCOP 52080 | Ribosomal proteins L15p and L18e |
| 2 | 2 | 2 | 0 | SCOP 46946 | S13-like H2TH domain |
| 2 | 2 | 1 | 0 | SCOP 51658 | Xylose isomerase-like |
| 2 | 2 | 1 | 1 | SCOP 53659 | Isocitrate/Isopropylmalate dehydrogenase-like |
| 2 | 2 | 2 | 0 | SCOP 55174 | Alpha-L RNA-binding motif |
| 2 | 2 | 1 | 0 | SCOP 111283 | Putative modulator of DNA gyrase, PmbA/TldD |
| 2 | 2 | 2 | 1 | SCOP 51713 | tRNA-guanine transglycosylase |
| 2 | 2 | 1 | 0 | SCOP 56276 | S-adenosylmethionine decarboxylase |
| 2 | 2 | 1 | 0 | SCOP 52121 | Lumazine synthase |
| 2 | 2 | 1 | 0 | SCOP 48576 | Terpenoid synthases |
| 2 | 2 | 1 | 1 | SCOP 56796 | Dehydroquinate synthase-like |
| 2 | 1 | 1 | 0 | SCOP 48371 | ARM repeat |
| 2 | 2 | 1 | 1 | SCOP 48256 | Citrate synthase |
| 2 | 2 | 1 | 1 | SCOP 48613 | Heme oxygenase-like |
| 2 | 2 | 1 | 0 | SCOP 46579 | Prefoldin |
| 2 | 2 | 1 | 0 | SCOP 52499 | Isochorismatase-like hydrolases |
| 2 | 2 | 1 | 0 | SCOP 63393 | RNA polymerase subunits |
| 2 | 2 | 1 | 0 | SCOP 55144 | LigT-like |
| 2 | 2 | 1 | 0 | SCOP 56317 | Carbon-nitrogen hydrolase |
| 2 | 2 | 1 | 1 | SCOP 52972 | ITPase-like |
| 2 | 2 | 1 | 0 | SCOP 81343 | Fumarate reductase respiratory complex transmembrane subunits |
| 2 | 2 | 1 | 0 | SCOP 49777 | PEBP-like |
| 2 | 2 | 2 | 0 | SCOP 53032 | tRNA-intron endonuclease catalytic domain-like |
| 2 | 2 | 2 | 0 | SCOP 55257 | RBP11-like subunits of RNA polymerase |
| 2 | 1 | 1 | 0 | SCOP 55008 | HMA, heavy metal-associated domain |
| 2 | 2 | 1 | 0 | SCOP 55961 | Bet v1-like |
| 2 | 2 | 1 | 0 | SCOP 69618 | HemD-like |
| 2 | 2 | 1 | 1 | SCOP 143447 | AMMECR1-like |
| 2 | 2 | 2 | 0 | SCOP 53800 | Chelatase |
| 2 | 2 | 1 | 0 | SCOP 101960 | Stabilizer of iron transporter SufD |
| 2 | 2 | 2 | 2 | SCOP 55931 | Glutamine synthetase/guanido kinase |
| 2 | 2 | 2 | 0 | SCOP 55040 | Molybdenum cofactor biosynthesis protein C, MoaC |
| 2 | 2 | 2 | 0 | SCOP 102405 | MCP/YpsA-like |
| 2 | 2 | 1 | 0 | SCOP 118196 | YaeB-like |
| 2 | 2 | 2 | 1 | SCOP 111352 | Ammonium transporter |
| 2 | 2 | 2 | 0 | SCOP 75712 | Rad50 coiled-coil Zn hook |
| 2 | 2 | 1 | 1 | SCOP 64167 | SurE-like |
| 2 | 2 | 2 | 1 | SCOP 52507 | Homo-oligomeric flavin-containing Cys decarboxylases, HFCD |
| 2 | 2 | 1 | 0 | SCOP 102215 | Creatininase |
| 2 | 2 | 1 | 0 | SCOP 69796 | Thymidylate synthase-complementing protein Thy1 |
| 2 | 2 | 2 | 1 | SCOP 53732 | Aconitase iron-sulfur domain |
| 2 | 2 | 1 | 1 | SCOP 117396 | TM1631-like |
| 2 | 1 | 1 | 0 | SCOP 51338 | Composite domain of metallo-dependent hydrolases |
| 2 | 1 | 1 | 0 | SCOP 63411 | LuxS/MPP-like metallohydrolase |
| 2 | 2 | 1 | 0 | SCOP 159659 | Cgl1923-like |
| 2 | 2 | 1 | 0 | SCOP 53163 | HybD-like |
| 2 | 2 | 2 | 0 | SCOP 53146 | Nitrogenase accessory factor-like |
| 2 | 2 | 1 | 2 | SCOP 51604 | Enolase C-terminal domain-like |
| 2 | 2 | 2 | 0 | SCOP 55186 | ThrRS/AlaRS common domain |
| 2 | 2 | 1 | 0 | SCOP 160980 | SSO1389-like |
| 2 | 2 | 2 | 0 | SCOP 63867 | MoeA C-terminal domain-like |
| 2 | 2 | 1 | 0 | SCOP 53092 | Creatinase/prolidase N-terminal domain |
| 2 | 1 | 1 | 0 | SCOP 82866 | Multidrug efflux transporter AcrB transmembrane domain |
| 2 | 2 | 1 | 1 | SCOP 48592 | GroEL equatorial domain-like |
| 2 | 2 | 2 | 0 | SCOP 50156 | PDZ domain-like |
| 2 | 2 | 2 | 1 | SCOP 56712 | Prokaryotic type I DNA topoisomerase |
| 2 | 2 | 2 | 0 | SCOP 51246 | Rudiment single hybrid motif |
| 2 | 2 | 1 | 0 | SCOP 55103 | FAD-linked oxidases, C-terminal domain |
| 2 | 2 | 1 | 0 | SCOP 58104 | Methyl-accepting chemotaxis protein (MCP) signaling domain |
| 2 | 2 | 1 | 0 | SCOP 48019 | post-AAA+ oligomerization domain-like |
| 2 | 2 | 2 | 0 | SCOP 52009 | Phosphohistidine domain |
| 2 | 2 | 1 | 0 | SCOP 57903 | FYVE/PHD zinc finger |
| 2 | 2 | 1 | 1 | SCOP 53671 | Aspartate/ornithine carbamoyltransferase |
| 2 | 2 | 2 | 1 | SCOP 54719 | Fe,Mn superoxide dismutase (SOD), C-terminal domain |
| 2 | 2 | 2 | 1 | SCOP 143968 | UbiD C-terminal domain-like |
| 2 | 2 | 2 | 0 | SCOP 54791 | Eukaryotic type KH-domain (KH-domain type I) |
| 2 | 2 | 1 | 1 | SCOP 54826 | Enolase N-terminal domain-like |
| 2 | 2 | 1 | 1 | SCOP 52029 | GroEL apical domain-like |
| 2 | 2 | 1 | 0 | SCOP 55060 | GHMP Kinase, C-terminal domain |
| 2 | 2 | 2 | 0 | SCOP 47364 | Domain of the SRP/SRP receptor G-proteins |
| 2 | 2 | 2 | 0 | SCOP 63737 | Leukotriene A4 hydrolase N-terminal domain |
| 2 | 2 | 2 | 0 | SCOP 141322 | NfeD domain-like |
| 2 | 1 | 1 | 1 | SCOP 55945 | TATA-box binding protein-like |
| 2 | 2 | 2 | 0 | SCOP 47794 | Rad51 N-terminal domain-like |
| 2 | 1 | 1 | 0 | SCOP 56053 | Ribosomal protein L6 |
| 2 | 2 | 1 | 0 | SCOP 53743 | FucI/AraA N-terminal and middle domains |
| 2 | 2 | 2 | 0 | SCOP 81271 | TGS-like |
| 2 | 2 | 2 | 1 | SCOP 55261 | GAD domain-like |
| 2 | 2 | 1 | 1 | SCOP 55666 | Ribonuclease PH domain 2-like |
| 2 | 2 | 1 | 0 | SCOP 54849 | GroEL-intermediate domain like |
| 2 | 2 | 2 | 0 | SCOP 88802 | Pre-PUA domain |
| 2 | 2 | 1 | 0 | SCOP 54585 | Cdc48 domain 2-like |
| 2 | 2 | 1 | 0 | SCOP 101821 | Aminopeptidase/glucanase lid domain |
| 1 | 1 | 1 | 0 | SCOP 56731 | DNA primase core |
| 1 | 1 | 1 | 1 | SCOP 56808 | Ribosomal protein L1 |
| 1 | 1 | 1 | 1 | SCOP 47973 | Ribosomal protein S7 |
| 1 | 1 | 1 | 1 | SCOP 75304 | Amidase signature (AS) enzymes |
| 1 | 1 | 1 | 0 | SCOP 54999 | Ribosomal protein S10 |
| 1 | 1 | 1 | 1 | SCOP 52166 | Ribosomal protein L4 |
| 1 | 1 | 1 | 0 | SCOP 54570 | Ribosomal protein S19 |
| 1 | 1 | 1 | 0 | SCOP 54843 | Ribosomal protein L22 |
| 1 | 1 | 1 | 0 | SCOP 54686 | Ribosomal protein L16p/L10e |
| 1 | 1 | 1 | 1 | SCOP 50193 | Ribosomal protein L14 |
| 1 | 1 | 1 | 1 | SCOP 56047 | Ribosomal protein S8 |
| 1 | 1 | 1 | 1 | SCOP 103491 | Preprotein translocase SecY subunit |
| 1 | 1 | 1 | 1 | SCOP 53784 | Phosphofructokinase |
| 1 | 1 | 1 | 1 | SCOP 53597 | Dihydrofolate reductase-like |
| 1 | 1 | 1 | 0 | SCOP 110324 | Ribosomal L27 protein-like |
| 1 | 1 | 1 | 1 | SCOP 51695 | PLC-like phosphodiesterases |
| 1 | 1 | 1 | 1 | SCOP 53748 | Phosphoglycerate kinase |
| 1 | 1 | 1 | 1 | SCOP 50324 | Inorganic pyrophosphatase |
| 1 | 1 | 1 | 0 | SCOP 160369 | Ribosomal protein L10-like |
| 1 | 1 | 1 | 0 | SCOP 81333 | F1F0 ATP synthase subunit C |
| 1 | 1 | 1 | 0 | SCOP 52161 | Ribosomal protein L13 |
| 1 | 1 | 1 | 0 | SCOP 47060 | S15/NS1 RNA-binding domain |
| 1 | 1 | 1 | 1 | SCOP 51351 | Triosephosphate isomerase (TIM) |
| 1 | 1 | 1 | 0 | SCOP 51730 | FAD-linked oxidoreductase |
| 1 | 1 | 1 | 0 | SCOP 52821 | Rhodanese/Cell cycle control phosphatase |
| 1 | 1 | 1 | 1 | SCOP 103263 | Chorismate synthase, AroC |
| 1 | 1 | 1 | 0 | SCOP 51283 | dUTPase-like |
| 1 | 1 | 1 | 1 | SCOP 52313 | Ribosomal protein S2 |
| 1 | 1 | 1 | 1 | SCOP 64005 | Undecaprenyl diphosphate synthase |
| 1 | 1 | 1 | 0 | SCOP 56655 | Carbohydrate phosphatase |
| 1 | 1 | 1 | 0 | SCOP 101908 | Putative isomerase YbhE |
| 1 | 1 | 1 | 0 | SCOP 53254 | Phosphoglycerate mutase-like |
| 1 | 1 | 1 | 1 | SCOP 55298 | YjgF-like |
| 1 | 1 | 1 | 0 | SCOP 46689 | Homeodomain-like |
| 1 | 1 | 1 | 0 | SCOP 55129 | Ribosomal protein L30p/L7e |
| 1 | 1 | 1 | 0 | SCOP 46561 | Ribosomal protein L29 (L29p) |
| 1 | 1 | 1 | 1 | SCOP 56104 | SAICAR synthase-like |
| 1 | 1 | 1 | 0 | SCOP 89957 | MTH1187/YkoF-like |
| 1 | 1 | 1 | 1 | SCOP 48140 | Ribosomal protein L19 (L19e) |
| 1 | 1 | 1 | 1 | SCOP 52042 | Ribosomal protein L32e |
| 1 | 1 | 1 | 1 | SCOP 52949 | Macro domain-like |
| 1 | 1 | 1 | 0 | SCOP 54575 | Ribosomal protein L31e |
| 1 | 1 | 1 | 0 | SCOP 52799 | (Phosphotyrosine protein) phosphatases II |
| 1 | 1 | 1 | 0 | SCOP 51726 | UROD/MetE-like |
| 1 | 1 | 1 | 0 | SCOP 103456 | Preprotein translocase SecE subunit |
| 1 | 1 | 1 | 0 | SCOP 53328 | Formyltransferase |
| 1 | 1 | 1 | 1 | SCOP 54534 | FKBP-like |
| 1 | 1 | 1 | 1 | SCOP 56322 | ADC synthase |
| 1 | 1 | 1 | 0 | SCOP 111278 | SSo0622-like |
| 1 | 1 | 1 | 0 | SCOP 159468 | AtpF-like |
| 1 | 1 | 1 | 0 | SCOP 69572 | Activating enzymes of the ubiquitin-like proteins |
| 1 | 1 | 1 | 0 | SCOP 144210 | Nop10-like SnoRNP |
| 1 | 1 | 1 | 0 | SCOP 89895 | FYSH domain |
| 1 | 1 | 1 | 0 | SCOP 54897 | Protease propeptides/inhibitors |
| 1 | 1 | 1 | 1 | SCOP 53774 | Glutaminase/Asparaginase |
| 1 | 1 | 1 | 1 | SCOP 56752 | D-aminoacid aminotransferase-like PLP-dependent enzymes |
| 1 | 1 | 1 | 0 | SCOP 74650 | Galactose mutarotase-like |
| 1 | 1 | 1 | 0 | SCOP 51306 | LexA/Signal peptidase |
| 1 | 1 | 1 | 0 | SCOP 51645 | Malate synthase G |
| 1 | 1 | 1 | 0 | SCOP 47819 | HRDC-like |
| 1 | 1 | 1 | 0 | SCOP 48662 | Ribosomal protein L39e |
| 1 | 1 | 1 | 0 | SCOP 49899 | Concanavalin A-like lectins/glucanases |
| 1 | 1 | 1 | 0 | SCOP 48208 | Six-hairpin glycosidases |
| 1 | 1 | 1 | 1 | SCOP 54919 | Nucleoside diphosphate kinase, NDK |
| 1 | 1 | 1 | 0 | SCOP 110849 | ParB/Sulfiredoxin |
| 1 | 1 | 1 | 0 | SCOP 103486 | V-type ATP synthase subunit C |
| 1 | 1 | 1 | 0 | SCOP 53056 | beta-carbonic anhydrase, cab |
| 1 | 1 | 1 | 1 | SCOP 56529 | FAH |
| 1 | 1 | 1 | 1 | SCOP 64153 | YjeF N-terminal domain-like |
| 1 | 1 | 1 | 0 | SCOP 55159 | eIF1-like |
| 1 | 1 | 1 | 0 | SCOP 46924 | RNA polymerase subunit RPB10 |
| 1 | 1 | 1 | 1 | SCOP 103378 | 2-methylcitrate dehydratase PrpD |
| 1 | 1 | 1 | 1 | SCOP 55909 | Pentein |
| 1 | 1 | 1 | 0 | SCOP 63562 | RPB6/omega subunit-like |
| 1 | 1 | 1 | 0 | SCOP 63965 | Precorrin-8X methylmutase CbiC/CobH |
| 1 | 1 | 1 | 1 | SCOP 141734 | HisI-like |
| 1 | 1 | 1 | 0 | SCOP 81648 | a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) |
| 1 | 1 | 1 | 0 | SCOP 144091 | Rhomboid-like |
| 1 | 1 | 1 | 1 | SCOP 111038 | YjbQ-like |
| 1 | 1 | 1 | 0 | SCOP 143243 | Nqo5-like |
| 1 | 1 | 1 | 0 | SCOP 144020 | FdhE-like |
| 1 | 1 | 1 | 1 | SCOP 51717 | Dihydropteroate synthetase-like |
| 1 | 1 | 1 | 0 | SCOP 55073 | Nucleotide cyclase |
| 1 | 1 | 1 | 0 | SCOP 55718 | SCP-like |
| 1 | 1 | 1 | 0 | SCOP 102712 | JAB1/MPN domain |
| 1 | 1 | 1 | 1 | SCOP 50494 | Trypsin-like serine proteases |
| 1 | 1 | 1 | 1 | SCOP 52255 | N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) |
| 1 | 1 | 1 | 1 | SCOP 142754 | NadA-like |
| 1 | 1 | 1 | 1 | SCOP 55874 | ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase |
| 1 | 1 | 1 | 0 | SCOP 82697 | PurS-like |
| 1 | 1 | 1 | 0 | SCOP 117916 | Fe-S cluster assembly (FSCA) domain-like |
| 1 | 1 | 1 | 0 | SCOP 56524 | Oxidoreductase molybdopterin-binding domain |
| 1 | 1 | 1 | 0 | SCOP 50022 | ISP domain |
| 1 | 1 | 1 | 0 | SCOP 103256 | Hypothetical protein TM0160 |
| 1 | 1 | 1 | 0 | SCOP 46767 | Methylated DNA-protein cysteine methyltransferase, C-terminal domain |
| 1 | 1 | 1 | 0 | SCOP 101744 | Rof/RNase P subunit-like |
| 1 | 1 | 1 | 0 | SCOP 89550 | PHP domain-like |
| 1 | 1 | 1 | 0 | SCOP 55797 | PR-1-like |
| 1 | 1 | 1 | 0 | SCOP 55154 | CYTH-like phosphatases |
| 1 | 1 | 1 | 0 | SCOP 81340 | Clc chloride channel |
| 1 | 1 | 1 | 0 | SCOP 161111 | Cation efflux protein transmembrane domain-like |
| 1 | 1 | 1 | 0 | SCOP 54690 | Molybdopterin synthase subunit MoaE |
| 1 | 1 | 1 | 0 | SCOP 140663 | TTHA0068-like |
| 1 | 1 | 1 | 0 | SCOP 50800 | PK beta-barrel domain-like |
| 1 | 1 | 1 | 0 | SCOP 117856 | AF0104/ALDC/Ptd012-like |
| 1 | 1 | 1 | 0 | SCOP 49879 | SMAD/FHA domain |
| 1 | 1 | 1 | 1 | SCOP 103365 | Hypothetical protein PH1602 |
| 1 | 1 | 1 | 0 | SCOP 52733 | Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT) |
| 1 | 1 | 1 | 0 | SCOP 158997 | Trm112p-like |
| 1 | 1 | 1 | 1 | SCOP 82544 | GckA/TtuD-like |
| 1 | 1 | 1 | 0 | SCOP 53213 | LigB-like |
| 1 | 1 | 1 | 0 | SCOP 89095 | GatB/YqeY motif |
| 1 | 1 | 1 | 0 | SCOP 48600 | Chorismate mutase II |
| 1 | 1 | 1 | 0 | SCOP 55826 | YbaK/ProRS associated domain |
| 1 | 1 | 1 | 0 | SCOP 159664 | CobE/GbiG C-terminal domain-like |
| 1 | 1 | 1 | 0 | SCOP 101386 | all-alpha NTP pyrophosphatases |
| 1 | 1 | 1 | 1 | SCOP 56747 | Prim-pol domain |
| 1 | 1 | 1 | 0 | SCOP 159234 | FomD-like |
| 1 | 1 | 1 | 0 | SCOP 143430 | TTP0101/SSO1404-like |
| 1 | 1 | 1 | 1 | SCOP 117457 | FumA C-terminal domain-like |
| 1 | 1 | 1 | 1 | SCOP 51219 | TRAP-like |
| 1 | 1 | 1 | 0 | SCOP 53041 | Resolvase-like |
| 1 | 1 | 1 | 0 | SCOP 159127 | HupF/HypC-like |
| 1 | 1 | 1 | 0 | SCOP 52309 | N-(deoxy)ribosyltransferase-like |
| 1 | 1 | 1 | 0 | SCOP 89155 | TorD-like |
| 1 | 1 | 1 | 0 | SCOP 49452 | Starch-binding domain-like |
| 1 | 1 | 1 | 0 | SCOP 55136 | Probable bacterial effector-binding domain |
| 1 | 1 | 1 | 1 | SCOP 56091 | DNA ligase/mRNA capping enzyme, catalytic domain |
| 1 | 1 | 1 | 1 | SCOP 56726 | DNA topoisomerase IV, alpha subunit |
| 1 | 1 | 1 | 1 | SCOP 159672 | CbiG N-terminal domain-like |
| 1 | 1 | 1 | 1 | SCOP 102198 | Putative cyclase |
| 1 | 1 | 1 | 0 | SCOP 82704 | AlbA-like |
| 1 | 1 | 1 | 0 | SCOP 46950 | Double-stranded DNA-binding domain |
| 1 | 1 | 1 | 0 | SCOP 74784 | Translin |
| 1 | 1 | 1 | 1 | SCOP 89124 | Nop domain |
| 1 | 1 | 1 | 0 | SCOP 111321 | AF1104-like |
| 1 | 1 | 1 | 0 | SCOP 142535 | AF0625-like |
| 1 | 1 | 1 | 1 | SCOP 111249 | Sulfolobus fructose-1,6-bisphosphatase-like |
| 1 | 1 | 1 | 1 | SCOP 160975 | AF1531-like |
| 1 | 1 | 1 | 0 | SCOP 160350 | Rnp2-like |
| 1 | 1 | 1 | 0 | SCOP 54984 | eEF-1beta-like |
| 1 | 1 | 1 | 0 | SCOP 69819 | MTH1598-like |
| 1 | 1 | 1 | 0 | SCOP 55287 | RPB5-like RNA polymerase subunit |
| 1 | 1 | 1 | 0 | SCOP 116820 | Rps17e-like |
| 1 | 1 | 1 | 0 | SCOP 160374 | RplX-like |
| 1 | 1 | 1 | 1 | SCOP 102462 | Peptidyl-tRNA hydrolase II |
| 1 | 1 | 1 | 0 | SCOP 158372 | AF1782-like |
| 1 | 1 | 1 | 0 | SCOP 69695 | SRP19 |
| 1 | 1 | 1 | 0 | SCOP 160363 | MTH889-like |
| 1 | 1 | 1 | 1 | SCOP 103165 | Ta1353-like |
| 1 | 1 | 1 | 1 | SCOP 69864 | Argininosuccinate synthetase, C-terminal domain |
| 1 | 1 | 1 | 0 | SCOP 52743 | Subtilisin-like |
| 1 | 1 | 1 | 1 | SCOP 56003 | Molybdenum cofactor-binding domain |
| 1 | 1 | 1 | 0 | SCOP 46589 | tRNA-binding arm |
| 1 | 1 | 1 | 0 | SCOP 69336 | Alpha subunit of glutamate synthase, C-terminal domain |
| 1 | 1 | 1 | 0 | SCOP 159713 | Dhaf3308-like |
| 1 | 1 | 1 | 0 | SCOP 82114 | Riboflavin kinase-like |
| 1 | 1 | 1 | 0 | SCOP 46906 | Ribosomal protein L11, C-terminal domain |
| 1 | 1 | 1 | 0 | SCOP 69304 | Tricorn protease N-terminal domain |
| 1 | 1 | 1 | 1 | SCOP 102645 | CoaB-like |
| 1 | 1 | 1 | 0 | SCOP 54821 | Ribosomal protein S3 C-terminal domain |
| 1 | 1 | 1 | 0 | SCOP 52935 | PK C-terminal domain-like |
| 1 | 1 | 1 | 1 | SCOP 111342 | CbiD-like |
| 1 | 1 | 1 | 0 | SCOP 81665 | Calcium ATPase, transmembrane domain M |
| 1 | 1 | 1 | 0 | SCOP 116726 | TrkA C-terminal domain-like |
| 1 | 1 | 1 | 0 | SCOP 56037 | PheT/TilS domain |
| 1 | 1 | 1 | 1 | SCOP 52418 | Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain |
| 1 | 1 | 1 | 0 | SCOP 51011 | Glycosyl hydrolase domain |
| 1 | 1 | 1 | 0 | SCOP 142984 | Nqo1 middle domain-like |
| 1 | 1 | 1 | 1 | SCOP 52021 | Carbamoyl phosphate synthetase, small subunit N-terminal domain |
| 1 | 1 | 1 | 1 | SCOP 54665 | CO dehydrogenase molybdoprotein N-domain-like |
| 1 | 1 | 1 | 0 | SCOP 57825 | Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain |
| 1 | 1 | 1 | 0 | SCOP 55447 | CO dehydrogenase flavoprotein C-terminal domain-like |
| 1 | 1 | 1 | 0 | SCOP 160964 | MalF N-terminal region-like |
| 1 | 1 | 1 | 0 | SCOP 81631 | PAP/OAS1 substrate-binding domain |
| 1 | 1 | 1 | 0 | SCOP 144083 | Magnesium transport protein CorA, transmembrane region |
| 1 | 1 | 1 | 0 | SCOP 46934 | UBA-like |
| 1 | 1 | 1 | 0 | SCOP 160240 | Cation efflux protein cytoplasmic domain-like |
| 1 | 1 | 1 | 0 | SCOP 47648 | Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain |
| 1 | 1 | 1 | 0 | SCOP 56327 | LDH C-terminal domain-like |
| 1 | 1 | 1 | 0 | SCOP 110921 | 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain |
| 1 | 1 | 1 | 0 | SCOP 75689 | Zinc-binding domain of translation initiation factor 2 beta |
| 1 | 1 | 1 | 0 | SCOP 100966 | Translation initiation factor 2 beta, aIF2beta, N-terminal domain |
| 1 | 1 | 1 | 0 | SCOP 54768 | dsRNA-binding domain-like |
| 1 | 1 | 1 | 0 | SCOP 54373 | FAD-linked reductases, C-terminal domain |
| 1 | 1 | 1 | 0 | SCOP 47741 | CO dehydrogenase ISP C-domain like |
| 1 | 1 | 1 | 1 | SCOP 158702 | Sec63 N-terminal domain-like |
| 1 | 1 | 1 | 0 | SCOP 52413 | UDP-glucose/GDP-mannose dehydrogenase C-terminal domain |
| 1 | 1 | 1 | 0 | SCOP 117892 | Band 7/SPFH domain |
| 1 | 1 | 1 | 0 | SCOP 55957 | Phosphoglucomutase, C-terminal domain |
| 1 | 1 | 1 | 0 | SCOP 54782 | Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain |
| 1 | 1 | 1 | 0 | SCOP 101852 | Bacterial fluorinating enzyme, C-terminal domain |
| 1 | 1 | 1 | 0 | SCOP 140490 | Nqo1C-terminal domain-like |
| 1 | 1 | 1 | 1 | SCOP 143975 | IlvD/EDD N-terminal domain-like |
| 1 | 1 | 1 | 1 | SCOP 47807 | 5' to 3' exonuclease, C-terminal subdomain |
| 1 | 1 | 1 | 1 | SCOP 47446 | Signal peptide-binding domain |
| 1 | 1 | 1 | 0 | SCOP 50615 | N-terminal domain of alpha and beta subunits of F1 ATP synthase |
| 1 | 1 | 1 | 1 | SCOP 56542 | Substrate-binding domain of HMG-CoA reductase |
| 1 | 1 | 1 | 0 | SCOP 102522 | Bacterial fluorinating enzyme, N-terminal domain |
| 1 | 1 | 1 | 0 | SCOP 116742 | eIF2alpha middle domain-like |
| 1 | 1 | 1 | 0 | SCOP 48108 | Carbamoyl phosphate synthetase, large subunit connection domain |
| 1 | 1 | 1 | 0 | SCOP 55481 | N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1 |
| 1 | 1 | 1 | 0 | SCOP 52025 | PA domain |
| 1 | 1 | 1 | 0 | SCOP 88798 | N-terminal, heterodimerisation domain of RBP7 (RpoE) |
| 1 | 1 | 1 | 1 | SCOP 142019 | Nqo1 FMN-binding domain-like |
| 1 | 1 | 1 | 0 | SCOP 54368 | Glutamine synthetase, N-terminal domain |
| 1 | 1 | 1 | 0 | SCOP 81653 | Calcium ATPase, transduction domain A |
| 1 | 1 | 1 | 1 | SCOP 46609 | Fe,Mn superoxide dismutase (SOD), N-terminal domain |
| 1 | 1 | 1 | 1 | SCOP 117018 | ATP-dependent DNA ligase DNA-binding domain |
| 1 | 1 | 1 | 0 | SCOP 69742 | Glutamyl tRNA-reductase catalytic, N-terminal domain |
| 1 | 1 | 1 | 0 | SCOP 110993 | eIF-2-alpha, C-terminal domain |
| 1 | 1 | 1 | 0 | SCOP 75615 | Siroheme synthase middle domains-like |
| 1 | 1 | 1 | 0 | SCOP 47917 | C-terminal domain of alpha and beta subunits of F1 ATP synthase |
| 1 | 1 | 1 | 0 | SCOP 48168 | R1 subunit of ribonucleotide reductase, N-terminal domain |
| 1 | 1 | 1 | 0 | SCOP 160527 | V-type ATPase subunit E-like |
| 1 | 1 | 1 | 0 | SCOP 159065 | Dom34/Pelota N-terminal domain-like |
| 1 | 1 | 1 | 1 | SCOP 52156 | Initiation factor IF2/eIF5b, domain 3 |
| 1 | 1 | 1 | 0 | SCOP 55003 | PAP/Archaeal CCA-adding enzyme, C-terminal domain |
| 1 | 1 | 1 | 0 | SCOP 64586 | C-terminal domain of ProRS |
| 1 | 1 | 1 | 1 | SCOP 55035 | NAD-binding domain of HMG-CoA reductase |
| 1 | 1 | 1 | 0 | SCOP 75445 | D-ribose-5-phosphate isomerase (RpiA), lid domain |
| 1 | 1 | 1 | 1 | SCOP 101353 | Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) |
| 1 | 1 | 1 | 0 | SCOP 56553 | Insert subdomain of RNA polymerase alpha subunit |
| 1 | 1 | 1 | 1 | SCOP 54893 | Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain |
| 1 | 1 | 1 | 0 | SCOP 109728 | Hypothetical protein AF0491, middle domain |
| 1 | 1 | 1 | 0 | SCOP 141300 | GatD N-terminal domain-like |
| 1 | 1 | 1 | 0 | SCOP 140914 | PriB N-terminal domain-like |
| 1 | 1 | 1 | 0 | SCOP 57770 | Methionyl-tRNA synthetase (MetRS), Zn-domain |
| 1 | 1 | 1 | 0 | SCOP 55267 | tRNA-intron endonuclease N-terminal domain-like |
| 1 | 1 | 1 | 0 | SCOP 52913 | RNA 3'-terminal phosphate cyclase, RPTC, insert domain |
