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CTD Chemicals (CC): Polycyclic Compounds 
(show info)
Biomedical Ontology
Like Gene Ontology (GO), biomedical ontology such as phenotype ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Biomedical ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI’s thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology Based on YP which is the major contributor to the ‘Ascomycete phenotype ontology’, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- UniProtKB KeyWords (KW) Ontology Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- CTD Diseases (CD) Ontology CD is MEDIC disease vocabulary that is modified by CTD from the "Diseases" [C] branch of Medical Subject Headings (MeSH), combined with genetic disorders from the Online Mendelian Inheritance in OMIM database.
- CTD Chemicals (CC) Ontology CC is chemical vocabulary that is adapted by CTD from the "Chemicals and Drugs" category and Supplementary Concept Records of Medical Subject Headings (MeSH, a hierarchical vocabulary used to index articles for MEDLINE/PubMed).
Jump to [ Top · Hierarchy · Annotations ]
Root: CC Hierarchy (CTD chemicals from Comparative Toxicogenomics Database)
| Shortest distance to current term (+ for parents, - for children) |
CC term [CC ID] <#Children> |
#Domains (Superfamily|Family) |
#Supra-domain (Single|Duplex|Triple) |
| + 1: | Chemicals [MESH:D] <13> |
| 0: | Polycyclic Compounds [MESH:D011083] <191> | (419|579) |
(431|390|204) |
| - 1: | Spiro Compounds [MESH:D013141] <991> | (19|20) |
(23|11|2) |
| - 1: | Bridged-Ring Compounds [MESH:D001952] <271> | (23|17) |
(24|8|3) |
| - 1: | Macrocyclic Compounds [MESH:D047028] <111> | (186|253) |
(192|153|75) |
| - 1: | Polycyclic Sesquiterpenes [MESH:D000081223] <64> | (16|18) |
(20|9|4) |
| - 1: | Polycyclic Aromatic Hydrocarbons [MESH:D011084] <59> | (230|311) |
(242|235|137) |
| - 1: | Fused-Ring Compounds [MESH:D000072473] <2> | (146|200) |
(156|135|57) |
| - 1: | (2.2)paracyclophane [MESH:C515344] | (0|0) |
(0|0|0) |
| - 1: | (2.2)paracyclophaneacetic acid [MESH:C445900] | (0|0) |
(0|0|0) |
| - 1: | (7.7)paracyclophane [MESH:C544518] | (0|0) |
(0|0|0) |
| - 1: | 1,2,3,10,11,12-hexamethoxy-6,7-dihydroxy-6,7-dimethyldibenzocyclooctadiene [MESH:C070768] | (0|0) |
(0|0|0) |
| - 1: | 1,2,4a,5,6,7,8,9,10,10a,11,11a-dodecahydro-11-hydroxy-11-methyl-7-phenylthiomethyl-5aH-5a,8-methanoc [MESH:C096577] | (0|0) |
(0|0|0) |
| - 1: | 1,2-benzocyclodecen-3-ol [MESH:C071121] | (0|0) |
(0|0|0) |
| - 1: | 1,2-benzocyclononen-3-ol [MESH:C071122] | (0|0) |
(0|0|0) |
| - 1: | 1,2-diketopyracene [MESH:C520329] | (0|0) |
(0|0|0) |
| - 1: | 1-((7-oxo-7H-benzo(de)anthracen-3-ylcarbamoyl)methyl)triethylammonium [MESH:C000602446] | (0|0) |
(0|0|0) |
| - 1: | 1-aminobenz(f)indan-2-ol [MESH:C514363] | (0|0) |
(0|0|0) |
| - 1: | 1-nitrocoronene [MESH:C040176] | (0|0) |
(0|0|0) |
| - 1: | 14-O-((4-aminobenzamide-2-methylpropane-2-yl)thioacetate)mutilin [MESH:C584483] | (0|0) |
(0|0|0) |
| - 1: | 16-isopropyl-5, 9-dimethyltetracyclo(10.2.2.0(1,10).0(4,9))hexadec-15-ene-5,14-dicarboxylic acid [MESH:C586229] | (0|0) |
(0|0|0) |
| - 1: | 2,3,9,10-tetrakis(trimethylsilyl)pentacene [MESH:C501940] | (0|0) |
(0|0|0) |
| - 1: | 2,7,12-trihexyloxytruexene [MESH:C551612] | (0|0) |
(0|0|0) |
| - 1: | 2-formyl-7,8-dipropyltetrathia(7)helicene [MESH:C000608185] | (0|0) |
(0|0|0) |
| - 1: | 2S-hydroxymutilin [MESH:C534902] | (0|0) |
(0|0|0) |
| - 1: | 3,4-seco-entkaurene [MESH:C546653] | (0|0) |
(0|0|0) |
| - 1: | 3,6-dibromophencyclone [MESH:C502796] | (0|0) |
(0|0|0) |
| - 1: | 3-(((2,2-dimethyl-1-(((2-methoxy-1-phenylethyl)amino)carbonyl)propyl)amino)carbonyl)-6-(3-methyl-4-p [MESH:C476600] | (0|0) |
(0|0|0) |
| - 1: | 3beta-stearyloxy-urs-12-ene [MESH:C511577] | (0|0) |
(0|0|0) |
| - 1: | 4,12-bis(diphenylphosphino)-(2.2)paracyclophane [MESH:C585681] | (0|0) |
(0|0|0) |
| - 1: | 4,21-deacetyl-deoxyyuzurimine [MESH:C539826] | (0|0) |
(0|0|0) |
| - 1: | 4,4a,6-trihydroxy-5-methoxyfluoren-2,9-dione [MESH:C525299] | (0|0) |
(0|0|0) |
| - 1: | 4,6-O-benzylidene-erythro-2-3-dideoxyhex-2-enopyranoside [MESH:C438448] | (0|0) |
(0|0|0) |
| - 1: | 4-((10-allyl-9,10-diazatricyclo(4.2.1.12,5)dec-9-yl)-(3-methoxyphenyl)methyl)-N,N-diethylbenzamide [MESH:C000589298] | (0|0) |
(0|0|0) |
| - 1: | 4-(1a,6-dihydro-1H-cyclopropa(a)inden-6a-yl)-1H-imidazole [MESH:C553281] | (0|0) |
(0|0|0) |
| - 1: | 4-nitro-13-amino-(2,2)paracyclophane [MESH:C528017] | (0|0) |
(0|0|0) |
| - 1: | 4-sulfo-benzocyclobutene [MESH:C540437] | (0|0) |
(0|0|0) |
| - 1: | 7,8-diropyltetrathia(7)helicene [MESH:C000608176] | (0|0) |
(0|0|0) |
| - 1: | A-317491 [MESH:C470346] | (0|0) |
(0|0|0) |
| - 1: | A-74528 [MESH:C506219] | (0|0) |
(0|0|0) |
| - 1: | AQX MN100 [MESH:C544924] | (0|0) |
(0|0|0) |
| - 1: | AT-11 compound [MESH:C528443] | (0|0) |
(0|0|0) |
| - 1: | FR 182877 [MESH:C408303] | (0|0) |
(0|0|0) |
| - 1: | FluoZin-3 [MESH:C451182] | (0|0) |
(0|0|0) |
| - 1: | GR135402 [MESH:C111326] | (0|0) |
(0|0|0) |
| - 1: | GSQ1530 [MESH:C471220] | (0|0) |
(0|0|0) |
| - 1: | MPT0B292 [MESH:C000626811] | (0|0) |
(0|0|0) |
| - 1: | Methyl 4,6-O-benzylidene-2-C-methoxycarbonylmethyl-ribo-hexopyranosid-3-ulose [MESH:C438447] | (0|0) |
(0|0|0) |
| - 1: | NOTA-PRGD2 [MESH:C000634460] | (0|0) |
(0|0|0) |
| - 1: | NSC 644221 [MESH:C519238] | (0|0) |
(0|0|0) |
| - 1: | Org 306039 [MESH:C000601287] | (0|0) |
(0|0|0) |
| - 1: | S 50131 [MESH:C000596272] | (0|0) |
(0|0|0) |
| - 1: | S 51434 [MESH:C000596273] | (0|0) |
(0|0|0) |
| - 1: | STA-21 [MESH:C500947] | (0|0) |
(0|0|0) |
| - 1: | TAN-1085 [MESH:C498261] | (0|0) |
(0|0|0) |
| - 1: | WMJ-8-B [MESH:C000627048] | (0|0) |
(0|0|0) |
| - 1: | acepentalene [MESH:C519944] | (0|0) |
(0|0|0) |
| - 1: | adenocaulone [MESH:C520436] | (0|0) |
(0|0|0) |
| - 1: | amethystin [MESH:C000590856] | (0|0) |
(0|0|0) |
| - 1: | aoibaclyin [MESH:C468030] | (0|0) |
(0|0|0) |
| - 1: | artochamin H [MESH:C524265] | (0|0) |
(0|0|0) |
| - 1: | artochamin I [MESH:C524266] | (0|0) |
(0|0|0) |
| - 1: | asterosaponin 1 [MESH:C515773] | (0|0) |
(0|0|0) |
| - 1: | azonia(6)helicene [MESH:C000610681] | (0|0) |
(0|0|0) |
| - 1: | benzo (7)annulen-7-amine [MESH:C000628676] | (0|0) |
(0|0|0) |
| - 1: | benzocyclobutene [MESH:C079040] | (0|0) |
(0|0|0) |
| - 1: | benzotricyclo(3.2.1.0(2,7))octane [MESH:C000592962] | (0|0) |
(0|0|0) |
| - 1: | betamethylepoxide [MESH:C524007] | (0|0) |
(0|0|0) |
| - 1: | bicalicene [MESH:C582386] | (0|0) |
(0|0|0) |
| - 1: | brevisin [MESH:C550958] | (0|0) |
(0|0|0) |
| - 1: | butapren [MESH:C006842] | (0|0) |
(0|0|0) |
| - 1: | butyl 2-cyano-3, 11-dioxours-1,12-dien-24-oate [MESH:C560735] | (0|0) |
(0|0|0) |
| - 1: | calyciphylline A [MESH:C479143] | (0|0) |
(0|0|0) |
| - 1: | calyciphylline B [MESH:C479142] | (0|0) |
(0|0|0) |
| - 1: | calyciphylline N [MESH:C535098] | (0|0) |
(0|0|0) |
| - 1: | calyciphylline O [MESH:C535099] | (0|0) |
(0|0|0) |
| - 1: | calyciphylline P [MESH:C535100] | (0|0) |
(0|0|0) |
| - 1: | carbaplatensimycin [MESH:C525363] | (0|0) |
(0|0|0) |
| - 1: | carboxyethylester-polyrotaxane [MESH:C466718] | (0|0) |
(0|0|0) |
| - 1: | ceratopicanol [MESH:C464976] | (0|0) |
(0|0|0) |
| - 1: | clarified slurry oil [MESH:C052511] | (0|0) |
(0|0|0) |
| - 1: | coronene [MESH:C012256] | (0|0) |
(0|0|0) |
| - 1: | cortistatin A [MESH:C531521] | (0|0) |
(0|0|0) |
| - 1: | cryptophane [MESH:C523242] | (0|0) |
(0|0|0) |
| - 1: | cryptophane A [MESH:C545484] | (0|0) |
(0|0|0) |
| - 1: | cryptophane E [MESH:C545485] | (0|0) |
(0|0|0) |
| - 1: | cryptophane-111 [MESH:C568309] | (0|0) |
(0|0|0) |
| - 1: | cryptophane-D [MESH:C583870] | (0|0) |
(0|0|0) |
| - 1: | cyclofen [MESH:C000632524] | (0|0) |
(0|0|0) |
| - 1: | cyclotriveratrylene [MESH:C483859] | (0|0) |
(0|0|0) |
| - 1: | daphniglaucin C [MESH:C585707] | (0|0) |
(0|0|0) |
| - 1: | dechlorane 602 [MESH:C556733] | (0|0) |
(0|0|0) |
| - 1: | dechlorane 603 [MESH:C556736] | (0|0) |
(0|0|0) |
| - 1: | dechlorane plus [MESH:C526360] | (0|0) |
(0|0|0) |
| - 1: | dehydrobenzo(12)annulene [MESH:C516931] | (0|0) |
(0|0|0) |
| - 1: | dehydrohomoplatencin [MESH:C554149] | (0|0) |
(0|0|0) |
| - 1: | dibenzo(a,e)cyclooctadiyne [MESH:C000611763] | (0|0) |
(0|0|0) |
| - 1: | dibenzobicyclo(2.2.2)octane [MESH:C096271] | (0|0) |
(0|0|0) |
| - 1: | dideoxy lomaiviticinone [MESH:C572035] | (0|0) |
(0|0|0) |
| - 1: | dihydro-dicyclohepta(ed,gh)pentalene [MESH:C511757] | (0|0) |
(0|0|0) |
| - 1: | dihydrodicyclopenta(ef,kl)heptalene [MESH:C511758] | (0|0) |
(0|0|0) |
| - 1: | distachyasin [MESH:C515888] | (0|0) |
(0|0|0) |
| - 1: | distillate aromatic extract [MESH:C101575] | (0|0) |
(0|0|0) |
| - 1: | dodecahedrane [MESH:C062580] | (0|0) |
(0|0|0) |
| - 1: | dodecahydro-7-(2-hydroxyethyl)-3a-methyl-1H-benz(e)indene-3-carbonitrile [MESH:C511625] | (0|0) |
(0|0|0) |
| - 1: | endo-5-methoxy-3-patchoulene [MESH:C580611] | (0|0) |
(0|0|0) |
| - 1: | erdacin [MESH:C544493] | (0|0) |
(0|0|0) |
| - 1: | ethynylhelicene [MESH:C560958] | (0|0) |
(0|0|0) |
| - 1: | funalenone [MESH:C405054] | (0|0) |
(0|0|0) |
| - 1: | garcibracteatone [MESH:C579594] | (0|0) |
(0|0|0) |
| - 1: | gomisin D [MESH:C082092] | (0|0) |
(0|0|0) |
| - 1: | gomisin J [MESH:C082091] | (0|0) |
(0|0|0) |
| - 1: | helicenediamine [MESH:C475850] | (0|0) |
(0|0|0) |
| - 1: | helicenes [MESH:C031660] | (0|0) |
(0|0|0) |
| - 1: | heliomycin [MESH:C007912] | (0|0) |
(0|0|0) |
| - 1: | heptacene [MESH:C526883] | (0|0) |
(0|0|0) |
| - 1: | hexa-peri-hexabenzocoronene [MESH:C507240] | (0|0) |
(0|0|0) |
| - 1: | hexacyclinol [MESH:C469535] | (0|0) |
(0|0|0) |
| - 1: | hyrtiosal [MESH:C517932] | (0|0) |
(0|0|0) |
| - 1: | isokobusone [MESH:C586976] | (0|0) |
(0|0|0) |
| - 1: | isoschizandrin [MESH:C482833] | (0|0) |
(0|0|0) |
| - 1: | lefamulin [MESH:C000591018] | (0|0) |
(0|0|0) |
| - 1: | lepistine [MESH:C000591955] | (0|0) |
(0|0|0) |
| - 1: | leucothol A [MESH:C096576] | (0|0) |
(0|0|0) |
| - 1: | lundurine A [MESH:C000597197] | (0|0) |
(0|0|0) |
| - 1: | lundurine B [MESH:C000590471] | (0|0) |
(0|0|0) |
| - 1: | lusianthrin [MESH:C521614] | (0|0) |
(0|0|0) |
| - 1: | lyconadin A [MESH:C435307] | (0|0) |
(0|0|0) |
| - 1: | lyconadin B [MESH:C514204] | (0|0) |
(0|0|0) |
| - 1: | lyconadin C [MESH:C582718] | (0|0) |
(0|0|0) |
| - 1: | macropodumine A [MESH:C520038] | (0|0) |
(0|0|0) |
| - 1: | macropodumine B [MESH:C520040] | (0|0) |
(0|0|0) |
| - 1: | macropodumine C [MESH:C520039] | (0|0) |
(0|0|0) |
| - 1: | macropodumine D [MESH:C518571] | (0|0) |
(0|0|0) |
| - 1: | macropodumine E [MESH:C518570] | (0|0) |
(0|0|0) |
| - 1: | macropodumine L [MESH:C539825] | (0|0) |
(0|0|0) |
| - 1: | maristentorin [MESH:C520723] | (0|0) |
(0|0|0) |
| - 1: | meloscine [MESH:C530682] | (0|0) |
(0|0|0) |
| - 1: | mutilin [MESH:C475718] | (0|0) |
(0|0|0) |
| - 1: | mutilin 14-O-(1-(1-methyl-4-nitro-3-propyl-1H-pyrazolecarboxamide)-2-methylpropane-2-yl)thioacetate [MESH:C544204] | (0|0) |
(0|0|0) |
| - 1: | neopetrocyclamine A [MESH:C000598717] | (0|0) |
(0|0|0) |
| - 1: | neopetrocyclamine B [MESH:C000598718] | (0|0) |
(0|0|0) |
| - 1: | nivetetracyclate A [MESH:C587706] | (0|0) |
(0|0|0) |
| - 1: | nivetetracyclate B [MESH:C587707] | (0|0) |
(0|0|0) |
| - 1: | nona-octanoyloxy tribenzocyclononatriene [MESH:C547434] | (0|0) |
(0|0|0) |
| - 1: | octahydro-7,7,8,8-tetramethyl-2,3b-methano-3bH-cyclopenta(1,3)cyclopropa(1,2)benzene-4-methanol [MESH:C534319] | (0|0) |
(0|0|0) |
| - 1: | pallidol [MESH:C535072] | (0|0) |
(0|0|0) |
| - 1: | pentacycloanammoxic acid methyl ester [MESH:C498357] | (0|0) |
(0|0|0) |
| - 1: | perfluorododecahedrane [MESH:C518590] | (0|0) |
(0|0|0) |
| - 1: | perinadine A [MESH:C512189] | (0|0) |
(0|0|0) |
| - 1: | phencyclone [MESH:C502795] | (0|0) |
(0|0|0) |
| - 1: | pieristoxin F [MESH:C011332] | (0|0) |
(0|0|0) |
| - 1: | pieristoxin G [MESH:C016643] | (0|0) |
(0|0|0) |
| - 1: | platencin [MESH:C520340] | (0|0) |
(0|0|0) |
| - 1: | pleuromutilin [MESH:C004262] | (0|0) |
(0|0|0) |
| - 1: | plukenetione A [MESH:C534123] | (0|0) |
(0|0|0) |
| - 1: | poly(pentaphenylene) [MESH:C515755] | (0|0) |
(0|0|0) |
| - 1: | popolohuanone E [MESH:C510740] | (0|0) |
(0|0|0) |
| - 1: | pradimicin M [MESH:C066994] | (0|0) |
(0|0|0) |
| - 1: | pradimicin O [MESH:C066996] | (0|0) |
(0|0|0) |
| - 1: | pradimicin P [MESH:C066997] | (0|0) |
(0|0|0) |
| - 1: | pseudo-para-divinyl(2.2)paracyclophane [MESH:C558832] | (0|0) |
(0|0|0) |
| - 1: | pyrenophane [MESH:C545420] | (0|0) |
(0|0|0) |
| - 1: | racemosolone [MESH:C000589006] | (0|0) |
(0|0|0) |
| - 1: | retigeranic acid A [MESH:C000606569] | (0|0) |
(0|0|0) |
| - 1: | ripromycin [MESH:C475318] | (0|0) |
(0|0|0) |
| - 1: | rubschisandrin [MESH:C049013] | (0|0) |
(0|0|0) |
| - 1: | salvadione-A [MESH:C484979] | (0|0) |
(0|0|0) |
| - 1: | schisanhenol [MESH:C045309] | (0|0) |
(0|0|0) |
| - 1: | schisanhenol B [MESH:C049012] | (0|0) |
(0|0|0) |
| - 1: | schisantherin B [MESH:C082090] | (0|0) |
(0|0|0) |
| - 1: | schisantherin C [MESH:C432788] | (0|0) |
(0|0|0) |
| - 1: | schizandrin [MESH:C011105] | (0|0) |
(0|0|0) |
| - 1: | schizandrin A [MESH:C034734] | (0|0) |
(0|0|0) |
| - 1: | schizandrin B [MESH:C015499] | (0|0) |
(0|0|0) |
| - 1: | schizandrin C [MESH:C031409] | (0|0) |
(0|0|0) |
| - 1: | selaginpulvilin D [MESH:C000626598] | (0|0) |
(0|0|0) |
| - 1: | stentorin I [MESH:C021252] | (0|0) |
(0|0|0) |
| - 1: | stentorin II [MESH:C021253] | (0|0) |
(0|0|0) |
| - 1: | suaveolol [MESH:C576568] | (0|0) |
(0|0|0) |
| - 1: | syntower bottoms [MESH:C101576] | (0|0) |
(0|0|0) |
| - 1: | tercyclopropanedimethanol [MESH:C516086] | (0|0) |
(0|0|0) |
| - 1: | tetarimycin A [MESH:C581112] | (0|0) |
(0|0|0) |
| - 1: | tetracyclo(4.2.1.1(3,6).0(2,7))dodeca-4,9-diene [MESH:C518481] | (0|0) |
(0|0|0) |
| - 1: | tetrathia(7)-helicene [MESH:C541928] | (0|0) |
(0|0|0) |
| - 1: | tricyclo(2.1.0.0 1,3)pentasilane [MESH:C521890] | (0|0) |
(0|0|0) |
| - 1: | tricyclo(2.1.0.0(1,3))pentagermane [MESH:C521891] | (0|0) |
(0|0|0) |
| - 1: | tricyclo(3.2.1.0(2,4))oct-6-ene [MESH:C516248] | (0|0) |
(0|0|0) |
| - 1: | tricyclo(4.1.0.0(2,7))heptene [MESH:C559097] | (0|0) |
(0|0|0) |
| - 1: | triethyl-2,5,8- tribenzyltrindane-2,5,8-tricarboxylate [MESH:C467075] | (0|0) |
(0|0|0) |
| - 1: | triptycyl(4)helicene [MESH:C121308] | (0|0) |
(0|0|0) |
| - 1: | tris(2-(4-phenyldiazenyl)phenylaminoethoxy)cyclotriveratrylene [MESH:C546736] | (0|0) |
(0|0|0) |
| - 1: | xylindein [MESH:C419334] | (0|0) |
(0|0|0) |
Jump to [ Top · Hierarchy ]
Superfamily( show details)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| DNA-glycosylase | 0 | DIRECT |
| Families 57/38 glycoside transferase middle domain | 0 | DIRECT |
| ValRS/IleRS/LeuRS editing domain | 0 | DIRECT |
| occludin/ELL-like | 0 | DIRECT |
| CAD & PB1 domains | 0 | DIRECT |
| Adenine nucleotide alpha hydrolases-like | 0 | DIRECT |
| PIN domain-like | 0 | DIRECT |
| MIR domain | 0 | DIRECT |
| Calcium-dependent phosphotriesterase | 0 | DIRECT |
| Serum albumin-like | 0 | DIRECT |
| BTG domain-like | 0 | DIRECT |
| BolA-like | 0 | DIRECT |
| PRC-barrel domain | 0 | DIRECT |
| Bacterial exopeptidase dimerisation domain | 0 | DIRECT |
| Ribosomal protein L30p/L7e | 0 | DIRECT |
| Class I glutamine amidotransferase-like | 0 | DIRECT |
| DEK C-terminal domain | 0 | DIRECT |
| GYF domain | 0 | DIRECT |
| Alpha-macroglobulin receptor domain | 0 | DIRECT |
| BAG domain | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
| Formate/glycerate dehydrogenase catalytic domain-like | 0 | DIRECT |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
| Cation efflux protein transmembrane domain-like | 0 | DIRECT |
| Purine and uridine phosphorylases | 0 | DIRECT |
| GINS helical bundle-like | 0 | DIRECT |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | DIRECT |
| Mediator hinge subcomplex-like | 0 | DIRECT |
| AN1-like Zinc finger | 0 | DIRECT |
| SIS domain | 0 | DIRECT |
| Di-copper centre-containing domain | 0 | DIRECT |
| EB1 dimerisation domain-like | 0 | DIRECT |
| CCHHC domain | 0 | DIRECT |
| DUSP-like | 0 | DIRECT |
| Inosine monophosphate dehydrogenase (IMPDH) | 0 | DIRECT |
| G protein-binding domain | 0 | DIRECT |
| beta-lactamase/transpeptidase-like | 0 | DIRECT |
| Alpha-L RNA-binding motif | 0 | DIRECT |
| Ribonuclease PH domain 2-like | 0 | DIRECT |
| LeuD/IlvD-like | 0 | DIRECT |
| 2Fe-2S ferredoxin-like | 0 | DIRECT |
| Protein prenylyltransferase | 0 | DIRECT |
| GHMP Kinase, C-terminal domain | 0 | DIRECT |
| F1F0 ATP synthase subunit C | 0 | DIRECT |
| Thyroglobulin type-1 domain | 0 | DIRECT |
| Nucleotide-binding domain | 0 | DIRECT |
| ARID-like | 0 | DIRECT |
| Peptidase/esterase 'gauge' domain | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | DIRECT |
| FAD-dependent thiol oxidase | 0 | DIRECT |
| PAH2 domain | 0 | DIRECT |
| Carbohydrate phosphatase | 0 | DIRECT |
| Formyltransferase | 0 | DIRECT |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
| I/LWEQ domain | 0 | DIRECT |
| Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
| Aminomethyltransferase beta-barrel domain | 0 | DIRECT |
| FF domain | 0 | DIRECT |
| N-(deoxy)ribosyltransferase-like | 0 | DIRECT |
| FMN-linked oxidoreductases | 0 | DIRECT |
| PAZ domain | 0 | DIRECT |
| Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
| LCCL domain | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| EPT/RTPC-like | 0 | DIRECT |
| Cytochrome b5-like heme/steroid binding domain | 0 | DIRECT |
| Trimeric LpxA-like enzymes | 0 | DIRECT |
| Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
| Troponin coil-coiled subunits | 0 | DIRECT |
| Lipoxigenase | 0 | DIRECT |
| Glutamine synthetase/guanido kinase | 0 | DIRECT |
| MAPEG domain-like | 0 | DIRECT |
| MOSC N-terminal domain-like | 0 | DIRECT |
| AXH domain | 0 | DIRECT |
| C-terminal domain of adenylylcyclase associated protein | 0 | DIRECT |
| PUG domain-like | 0 | DIRECT |
| Thiolase-like | 0 | DIRECT |
| PHM/PNGase F | 0 | DIRECT |
| Nucleoplasmin-like core domain | 0 | DIRECT |
| Arginase/deacetylase | 0 | DIRECT |
| P-domain of calnexin/calreticulin | 0 | DIRECT |
| AhpD-like | 0 | DIRECT |
| LanC-like | 0 | DIRECT |
| Sema domain | 0 | DIRECT |
| BRK domain-like | 0 | DIRECT |
| Pseudouridine synthase | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| MgtE membrane domain-like | 0 | DIRECT |
| Amidase signature (AS) enzymes | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| Peptidylarginine deiminase Pad4, middle domain | 0 | DIRECT |
| ClpS-like | 0 | DIRECT |
| Indolic compounds 2,3-dioxygenase-like | 0 | DIRECT |
| MIT domain | 0 | DIRECT |
| Nicotinate/Quinolinate PRTase C-terminal domain-like | 0 | DIRECT |
| ISP domain | 0 | DIRECT |
| Carbon-nitrogen hydrolase | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | DIRECT |
| Uracil-DNA glycosylase-like | 0 | DIRECT |
| Rudiment single hybrid motif | 0 | DIRECT |
| Phosphoglycerate mutase-like | 0 | DIRECT |
| Anaphylotoxins (complement system) | 0 | DIRECT |
| Nop domain | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| FAD-binding/transporter-associated domain-like | 0 | DIRECT |
| S13-like H2TH domain | 0 | DIRECT |
| Metallothionein | 0 | DIRECT |
| Stathmin | 0 | DIRECT |
| Phosphoenolpyruvate/pyruvate domain | 0 | DIRECT |
| Periplasmic binding protein-like II | 0 | DIRECT |
| Clathrin adaptor appendage domain | 0 | DIRECT |
| YWTD domain | 0 | DIRECT |
| PEBP-like | 0 | DIRECT |
| Glycoside hydrolase/deacetylase | 0 | DIRECT |
| SGNH hydrolase | 0 | DIRECT |
| Release factor | 0 | DIRECT |
| ADP-ribosylglycohydrolase | 0 | DIRECT |
| TB module/8-cys domain | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| Assembly domain of cartilage oligomeric matrix protein | 0 | DIRECT |
| Ribosomal L27 protein-like | 0 | DIRECT |
| TSP type-3 repeat | 0 | DIRECT |
| JAB1/MPN domain | 0 | DIRECT |
| FAD-linked oxidases, C-terminal domain | 0 | DIRECT |
| ITPase-like | 0 | DIRECT |
| Plexin repeat | 0 | DIRECT |
| FMT C-terminal domain-like | 0 | DIRECT |
| Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain | 0 | DIRECT |
| Alanine racemase C-terminal domain-like | 0 | DIRECT |
| DHS-like NAD/FAD-binding domain | 0 | DIRECT |
| HR1 repeat | 0 | DIRECT |
| RmlC-like cupins | 0 | DIRECT |
| Gamma-glutamyl cyclotransferase-like | 0 | DIRECT |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
| TAFH domain-like | 0 | DIRECT |
| BRCT domain | 0 | DIRECT |
| PLP-binding barrel | 0 | DIRECT |
| ATP-dependent DNA ligase DNA-binding domain | 0 | DIRECT |
| SCP-like | 0 | DIRECT |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
| AlbA-like | 0 | DIRECT |
| R3H domain | 0 | DIRECT |
| beta-sandwich domain of Sec23/24 | 0 | DIRECT |
| DNA polymerase beta, N-terminal domain-like | 0 | DIRECT |
| FMN-binding split barrel | 0 | DIRECT |
| Phosphofructokinase | 0 | DIRECT |
| GTF2I-like repeat | 0 | DIRECT |
| BSD domain-like | 0 | DIRECT |
| Aconitase iron-sulfur domain | 0 | DIRECT |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | DIRECT |
| Clc chloride channel | 0 | DIRECT |
| Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain | 0 | DIRECT |
| Heme-dependent peroxidases | 0 | DIRECT |
| Bcl-2 inhibitors of programmed cell death | 0 | DIRECT |
| Eferin C-derminal domain-like | 0 | DIRECT |
| Microbial and mitochondrial ADK, insert "zinc finger" domain | 0 | DIRECT |
| HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
| VHP, Villin headpiece domain | 0 | DIRECT |
| Integrin beta tail domain | 0 | DIRECT |
| Subtilisin-like | 0 | DIRECT |
| PK beta-barrel domain-like | 0 | DIRECT |
| Guanido kinase N-terminal domain | 0 | DIRECT |
| LysM domain | 0 | DIRECT |
| Proteasome activator | 0 | DIRECT |
| 4Fe-4S ferredoxins | 0 | DIRECT |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
| N-terminal domain of cbl (N-cbl) | 0 | DIRECT |
| BEACH domain | 0 | DIRECT |
| Fe-S cluster assembly (FSCA) domain-like | 0 | DIRECT |
| PurM N-terminal domain-like | 0 | DIRECT |
| Acyl-CoA dehydrogenase NM domain-like | 0 | DIRECT |
| Endosomal sorting complex assembly domain | 0 | DIRECT |
| Six-hairpin glycosidases | 0 | DIRECT |
| WGR domain-like | 0 | DIRECT |
| Putative isomerase YbhE | 0 | DIRECT |
| A heparin-binding domain | 0 | DIRECT |
| Fibrinogen coiled-coil and central regions | 0 | DIRECT |
| KA1-like | 0 | DIRECT |
| FKBP-like | 0 | DIRECT |
| Hect, E3 ligase catalytic domain | 0 | DIRECT |
| Apolipoprotein A-I | 0 | DIRECT |
| RBP11-like subunits of RNA polymerase | 0 | DIRECT |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Transcription factor IIA (TFIIA), alpha-helical domain | 0 | DIRECT |
| Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | DIRECT |
| Leukotriene A4 hydrolase N-terminal domain | 0 | DIRECT |
| Sec7 domain | 0 | DIRECT |
| PWI domain | 0 | DIRECT |
| Proton glutamate symport protein | 0 | DIRECT |
| Probable bacterial effector-binding domain | 0 | DIRECT |
| Transcription factor IIA (TFIIA), beta-barrel domain | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| IP3 receptor type 1 binding core, domain 2 | 0 | DIRECT |
| Oxysterol-binding protein-like | 0 | DIRECT |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | DIRECT |
| His-Me finger endonucleases | 0 | DIRECT |
| Mitochondrial cytochrome c oxidase subunit VIIa | 0 | DIRECT |
| Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
| DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
| MAST3 pre-PK domain-like | 0 | DIRECT |
| GFP-like | 0 | DIRECT |
| Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
| RGC domain-like | 0 | DIRECT |
| PriA/YqbF domain | 0 | DIRECT |
| Methylglyoxal synthase-like | 0 | DIRECT |
| Chicken cartilage matrix protein | 0 | DIRECT |
| alpha/beta knot | 0 | DIRECT |
| Nucleoporin domain | 0 | DIRECT |
| alpha-catenin/vinculin-like | 0 | DIRECT |
| Pentein | 0 | DIRECT |
| Ribosomal protein L1 | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| Ribosomal protein S10 | 0 | DIRECT |
| DLC | 0 | DIRECT |
| Serine protease inhibitors | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
| Transferrin receptor-like dimerisation domain | 0 | DIRECT |
| Delta-sleep-inducing peptide immunoreactive peptide | 0 | DIRECT |
| PABC (PABP) domain | 0 | DIRECT |
| Actin-crosslinking proteins | 0 | DIRECT |
| Amine oxidase N-terminal region | 0 | DIRECT |
| STAT | 0 | DIRECT |
| ALDH-like | 0 | DIRECT |
| Connexin43 | 0 | DIRECT |
| ABC transporter transmembrane region | 0 | DIRECT |
| Galactose mutarotase-like | 0 | DIRECT |
| Amine oxidase catalytic domain | 0 | DIRECT |
| YVTN repeat-like/Quinoprotein amine dehydrogenase | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Ribosomal protein S18 | 0 | DIRECT |
| 3-carboxy-cis,cis-mucoante lactonizing enzyme | 0 | DIRECT |
| Restriction endonuclease-like | 0 | DIRECT |
| SPOC domain-like | 0 | DIRECT |
| Seven-hairpin glycosidases | 0 | DIRECT |
| Single hybrid motif | 0 | DIRECT |
| Glycolipid transfer protein, GLTP | 0 | DIRECT |
| Terpenoid cyclases/Protein prenyltransferases | 0 | DIRECT |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | DIRECT |
| ACT-like | 0 | DIRECT |
| Cysteine alpha-hairpin motif | 0 | DIRECT |
| TIMP-like | 0 | DIRECT |
| Small-conductance potassium channel | 0 | DIRECT |
| HIT-like | 0 | DIRECT |
| Rhodanese/Cell cycle control phosphatase | 0 | DIRECT |
| PRTase-like | 0 | DIRECT |
| L27 domain | 0 | DIRECT |
| C-terminal domain of PLC-beta | 0 | DIRECT |
| Integrin domains | 0 | DIRECT |
| Creatinase/prolidase N-terminal domain | 0 | DIRECT |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | DIRECT |
| Mss4-like | 0 | DIRECT |
| USP8 N-terminal domain-like | 0 | DIRECT |
| Mib/herc2 domain-like | 0 | DIRECT |
| Mannose 6-phosphate receptor domain | 0 | DIRECT |
| Nucleotidylyl transferase | 0 | DIRECT |
| Oncogene products | 0 | DIRECT |
| S15/NS1 RNA-binding domain | 0 | DIRECT |
| L-aspartase-like | 0 | DIRECT |
| Hermes dimerisation domain | 0 | DIRECT |
| Homocysteine S-methyltransferase | 0 | DIRECT |
| Activating enzymes of the ubiquitin-like proteins | 0 | DIRECT |
| Notch domain | 0 | DIRECT |
| Ribosomal protein L16p/L10e | 0 | DIRECT |
| Ribosomal proteins S24e, L23 and L15e | 0 | DIRECT |
| DNA-binding domain | 0 | DIRECT |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
| FAD-linked oxidoreductase | 0 | DIRECT |
| Transcription factor STAT-4 N-domain | 0 | DIRECT |
| AraD/HMP-PK domain-like | 0 | DIRECT |
| FAD-linked reductases, C-terminal domain | 0 | DIRECT |
| Class II aaRS ABD-related | 0 | DIRECT |
| WW domain | 0 | DIRECT |
| RNase III domain-like | 0 | DIRECT |
| GAT-like domain | 0 | DIRECT |
| PapD-like | 0 | DIRECT |
| Translation proteins SH3-like domain | 0 | DIRECT |
| Phosphoglucomutase, first 3 domains | 0 | DIRECT |
| PurM C-terminal domain-like | 0 | DIRECT |
| Translational machinery components | 0 | DIRECT |
| VPS9 domain | 0 | DIRECT |
| P-loop containing nucleoside triphosphate hydrolases | 0.00000007953 | DIRECT |
| ARM repeat | 0.0000002317 | DIRECT |
| PH domain-like | 0.000004922 | DIRECT |
| SH3-domain | 0.00001001 | DIRECT |
| EGF/Laminin | 0.00007854 | DIRECT |
| FYVE/PHD zinc finger | 0.0004334 | DIRECT |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.0005744 | DIRECT |
| Cytochrome P450 | 0.001792 | INHERITED FROM: S-sulindac || Carbaryl || Naphthols || Lactams, Macrocyclic || pyrene || Indans || Pregnenes || Cyclopentane Monoterpenes || Estrone || Pyrethrins || Fused-Ring Compounds || obeticholic acid || Cholestanols || Dehydroepiandrosterone || 1-phenylazo-2-naphthol || 17-alpha-Hydroxyprogesterone || benzo(c)phenanthrene || 1,4-naphthoquinone || Phenanthrenes || decamethrin || 1-chloropyrene || thiocoraline || 4-hydroxyretinoic acid || alizarin || Bile Acids and Salts || Cyclodextrins || 1,3-dinitropyrene || epoxiconazole || 6-methylchrysene || Dactinomycin || 1-Naphthylamine || Pregnenediones || 6-chrysenamine || Clobetasol || 2-hydroxyestradiol || Alitretinoin || chrysophanic acid || shikonin || Dihydroxycholecalciferols || Androstanes || Cyclobutanes || 2,6-dimethylnaphthalene || Dextrorphan || 2-nitrofluoranthene || phenanthrene || physcione || deoxynivalenol || Anthracenes || 3-methylchrysene || 2-methyl-5-isopropenylcyclohex-2-enone oxime || Loratadine || 4-oxoretinoic acid || Calcitriol || indeno(1,2,3-cd)pyrene || Eucalyptol || Rifamycins || 3,6-dinitrobenzopyrene || Cholanes || 1-naphthol || cyhalothrin || Metalloporphyrins || Phenalenes || Benz(a)Anthracenes || Norsteroids || benzotriphenylene || dibenzoanthracene-3,4-dihydrodiol || Epoxy Compounds || Indenes || Cholic Acids || Cholestanes || Propranolol || Dibenzocycloheptenes || 6-nitrobenzo(a)pyrene || Hydroxytestosterones || naphtho(2,3-a)pyrene || sibutramine || 2-Naphthylamine || Polyketides || Permethrin || Secosteroids || fenvalerate || 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid || Betamethasone || Methyltestosterone || Ketosteroids || naphthalene || purpurin || Acenaphthenes || Cyclopentanes || 4,4'-cyclohexylidenebisphenol || Macrocyclic Compounds || 6-nitrochrysene || UAB 30 || Limonene || triptolide || 9,10-Dimethyl-1,2-benzanthracene || dimemorfan || 9-phenanthrol || trans-1,2-dihydro-1,2-naphthalenediol || Benzocycloheptenes || Dextromethorphan || Ethers, Cyclic || HT-2 toxin || Buspirone || benzo(a)pyrene 7,8-dihydrodiol || 5-methylchrysene || Desoxycorticosterone || Emodin || Trichothecenes || Morphinans || Fluorenes || Naphthalenes || Spiro Compounds || Depsipeptides || 5,12-naphthacenequinone || 4-methylchrysene || Cholestenes || Hydrocortisone || walrycin A || paricalcitol || Sertraline |
| FAD/NAD(P)-binding domain | 0.002629 | INHERITED FROM: Cyclosporins || juglone || Hydroxycholecalciferols || Dihydroxycholecalciferols || Calcitriol || Xanthophylls || Cholestenes |
| Protein kinase-like (PK-like) | 0.002683 | INHERITED FROM: Ouabain || Macrolides || Lactams, Macrocyclic || ethyl 8-oxo-8H-acenaphtho(1,2-b)pyrrole-9-carboxylate || tylophorine || Lycopene || dioscin || 3-O-caffeoyl-1-methylquinic acid || Diosgenin || NSC 680410 || Bile Acids and Salts || Cyclodextrins || beta-Cyclodextrins || 4-acetylantroquinonol B || Sapogenins || chrysophanic acid || Androstanes || 5H-benzo(4,5)cyclohepta(1,2-b)pyridin-5-one || aucubin || tamibarotene || Cholanes || 3-(2-(dimethylamino)isopropoxy)-1-hydroxybenzo(b)naphtho(2,3-d)furan-6,11-dione || Indenes || Cholic Acids || Maytansine || Pyrenes || Polyketides || Fulvestrant || Cyclodecanes || napabucasin || Camphanes || Spirostans || tanespimycin || Cardanolides || Win 55212-2 || liposomal doxorubicin || 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione || cyanoginosin LR || Benzocycloheptenes || Polycyclic Aromatic Hydrocarbons || Microcystins || Cardiac Glycosides || picropodophyllin || Naphthalenes || beta-ionone || Iridoid Glycosides |
| PDZ domain-like | 0.002741 | INHERITED FROM: Polycyclic Aromatic Hydrocarbons || benzo(e)pyrene |
| Growth factor receptor domain | 0.003063 | INHERITED FROM: Pregnenediones || Hydroxycholecalciferols || Dihydroxycholecalciferols || Calcitriol || Paclitaxel || napabucasin |
| Nuclear receptor ligand-binding domain | 0.006347 | INHERITED FROM: AGN 193109 || Norethindrone Acetate || Toxaphene || Carbaryl || Lactams, Macrocyclic || pyrene || Indans || 2,2-bis(4-glycidyloxyphenyl)propane || Cortodoxone || Cholesterol || Cyclopentane Monoterpenes || Estrone || Pyrethrins || Mifepristone || Fused-Ring Compounds || Retinoids || Bridged Bicyclo Compounds || Equilin || Steroids, Chlorinated || Dehydroepiandrosterone || Valinomycin || Retinaldehyde || Megestrol || Camphor || Phenanthrenes || Budesonide || 1-hydroxypyrene || Oxymetholone || enzacamene || 4-hydroxyretinoic acid || phantolid || Bile Acids and Salts || Pregnanediones || tibolone || Alitretinoin || 1,1-bis(4-hydroxyphenyl)cyclohexane || Pregnadienediols || Medroxyprogesterone || Androstanes || Steroids, Heterocyclic || eldecalcitol || Anthracenes || Bridged-Ring Compounds || beta Carotene || Rifamycins || Danazol || tetralin || Epirubicin || calcipotriene || Cholanes || cyhalothrin || Fenretinide || dihydroxy-vitamin D3 || Hydroxycholesterols || Ciclopirox || Indenes || Cholic Acids || Cholestanes || Medroxyprogesterone Acetate || Sterols || Simvastatin || 9-cis-retinal || Prednisolone || phenothrin || 4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid || Bexarotene || Cyproterone Acetate || Polyketides || Permethrin || Fulvestrant || SR 11237 || fenvalerate || Digitoxin || 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid || Cycloparaffins || Betamethasone || Idarubicin || Ketosteroids || Corticosterone || Cardenolides || Chenodeoxycholic Acid || Cyclopentanes || Macrocyclic Compounds || 2,6-diisopropylnaphthalene || Cardanolides || Cyproterone || Digitalis Glycosides || LG 100268 || GSK 8470 || Ethers, Cyclic || ciclesonide || pirarubicin || 3-benzylidene camphor || Estriol || Cardiac Glycosides || Promegestone || Trichothecenes || Triamcinolone || Cyclohexanecarboxylic Acids || Fluorenes || acetyl methyl tetramethyl tetralin || sulindac sulfone || Cyclohexenes || Naphthalenes || diisononyl 1,2-cyclohexanedicarboxylic acid || Depsipeptides || Cholestenes || versalide || 5-alpha-Dihydroprogesterone || paricalcitol |
| TSP-1 type 1 repeat | 0.007667 | INHERITED FROM: Benzopyrenes || benzo(e)pyrene || Methylprednisolone |
| Ubiquitin-like | 0.007737 | INHERITED FROM: Benzopyrenes |
| GTPase activation domain, GAP | 0.007998 | INHERITED FROM: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide || Polycyclic Aromatic Hydrocarbons |
| Metalloproteases ("zincins"), catalytic domain | 0.01 | INHERITED FROM: mibolerone || pyrazolanthrone || manganese(III)-tetrakis(4-benzoic acid)porphyrin || cyclo(Trp-Asp-Pro-Val-Leu) || 1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one || Doxycycline || 3-caffeoyl-4-dihydrocaffeoylquinic acid || Tetracyclines || Progesterone |
| Interleukin 8-like chemokines | 0.01038 | INHERITED FROM: Oxytetracycline || Ursodeoxycholic Acid || Cholesterol || Pregnenes || Mifepristone || Bridged Bicyclo Compounds || butenafine || Steroids, Chlorinated || Proscillaridin || Fludrocortisone || roflumilast N-oxide || Budesonide || enzacamene || Beclomethasone || Norbornanes || pevonedistat || Pregnenediones || Terbinafine || Minocycline || sirtinol || Lanatosides || Cholestenones || beta Carotene || Bicyclic Monoterpenes || 1-nitropyrene || Sterols || Simvastatin || Prednisolone || Dibenzocycloheptenes || meclocycline || 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol || Cyclopropanes || Polyketides || Digitoxigenin || Strophanthins || 3-nitrofluoranthene || Fulvestrant || Camphanes || Digitoxin || Betamethasone || Bufanolides || Antimycin A || primycin || Roflumilast || beta-hydroxy simvastatin acid || Digitalis Glycosides || Benzocycloheptenes || Ergosterol || 3-aminofluoranthene || Withanolides || Phytosterols || Chrysenes || Tetracyclines || Digoxin || Methylprednisolone || BIRB 796 || Trichothecenes || Morphinans || Fluorenes || Cholestenes || coagulin-L || Morphine Derivatives |
| SCOP hierarchy in SUPERFAMILY | 0.01272 | INHERITED FROM: yessotoxin || Metribolone || Oxocins |
| Bromodomain | 0.01322 | INHERITED FROM: Pregnadienes || deoxynivalenol || Cyproterone Acetate |
| GST C-terminal domain-like | 0.01895 | INHERITED FROM: Okadaic Acid || dibenzo(a,l)pyrene || Androstenedione || microcystin RR || beta Carotene || apocarotenal || 17-Ketosteroids || Ketosteroids || Bile Pigments || Microcystins || Naphthalenesulfonates || apple polyphenol extract || Spiro Compounds |
| SH2 domain | 0.02657 | INHERITED FROM: naphtho(1,2-b)furan-4,5-dione || benzo(a)pyrene-3,6-quinone || 4-acetylantroquinonol B || benzo(a)pyrene-1,6-quinone || tamibarotene || Simvastatin || Cyclohexanones || caryophyllene || Naphthalenes |
| NAD(P)-binding Rossmann-fold domains | 0.02811 | INHERITED FROM: 9,10-phenanthrenequinone || Estrone || Retinoids || Androstenediols || Androstenedione || 1,2-naphthoquinone || Ketosteroids || Cortisone || Macrocyclic Compounds || Isotretinoin || Androstenediol |
| Second domain of FERM | 0.03394 | INHERITED FROM: Pyrenes || Benzopyrenes |
| PYP-like sensor domain (PAS domain) | 0.03824 | INHERITED FROM: Lactams, Macrocyclic || Bridged Bicyclo Compounds || eldecalcitol || Rifamycins || dihydroxy-vitamin D3 || Pyrenes || Cyproterone Acetate || azaspiracid || Fulvestrant || Benzopyrenes || Cyclopentanes || Cyproterone || Digitalis Glycosides || Digoxin || Rifampin || Fluorenes |
| Calponin-homology domain, CH-domain | 0.04082 | INHERITED FROM: Fused-Ring Compounds || Polycyclic Aromatic Hydrocarbons |
| Alkaline phosphatase-like | 0.04806 | INHERITED FROM: yessotoxin || Oxocins |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.0489 | INHERITED FROM: Pyrenes || Bryostatins |
| Mitochondrial carrier | 0.07591 | INHERITED FROM: Abietanes || CD 437 || Sesquiterpenes, Eudesmane || Thapsigargin || dehydroabietylamine || enniatins || Polycyclic Sesquiterpenes || Sesquiterpenes, Guaiane || Cycloheptanes |
| Fibronectin type III | 0.07717 | INHERITED FROM: Pregnenediones || Pyrenes || Cycloparaffins || benzo(e)pyrene |
| SNARE fusion complex | 0.08435 | INHERITED FROM: Heroin || Morphinans || Morphine Derivatives |
| HD-domain/PDEase-like | 0.09402 | INHERITED FROM: Cyclopropanes || Cilomilast || Roflumilast || Cyclohexanecarboxylic Acids |
| TNF receptor-like | 0.1049 | INHERITED FROM: Menthol || dioscin || Cyclohexanols || Diosgenin || Cyclohexane Monoterpenes || 4-(3-(1-adamantyl)-4-hydroxyphenyl)-3-chlorocinnamic acid || Epoxy Compounds || Paclitaxel || aloe emodin || Cyclohexanes || Spirostans || motexafin gadolinium || Nystatin || 2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyc |
| ADP-ribosylation | 0.1049 | INHERITED FROM: Phenanthrenes || N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride |
| Cysteine-rich domain | 0.1145 | INHERITED FROM: Emodin || Bryostatins |
| Integrin alpha N-terminal domain | 0.1169 | INHERITED FROM: Pregnenes || Pregnenediones || Lithocholic Acid || Tetracycline || napabucasin || Tetracyclines || Progesterone |
| Hemopexin-like domain | 0.1169 | INHERITED FROM: Ouabain || Mifepristone || pyrazolanthrone || manganese(III)-tetrakis(4-benzoic acid)porphyrin || Chlorogenic Acid || cyclo(Trp-Asp-Pro-Val-Leu) || 1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one || Pregnenediones || Tetrapyrroles || Lovastatin || Anthracenes || Estradiol || Simvastatin || Wortmannin || Paclitaxel || Doxycycline || Cyclodecanes || 3-caffeoyl-4-dihydrocaffeoylquinic acid || Cardanolides || Porphyrins || Tetracyclines || Progesterone || Cardiac Glycosides || bufalin || Spiro Compounds |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.1292 | INHERITED FROM: microcystin RR || Microcystins |
| Sm-like ribonucleoproteins | 0.1301 | INHERITED FROM: CD 437 || Bridged-Ring Compounds || yessotoxin || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Ethers, Cyclic || Adamantane || Oxocins |
| Ribosomal protein S5 domain 2-like | 0.1413 | INHERITED FROM: CD 437 |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.1413 | INHERITED FROM: Ouabain || Strophanthins || Cardenolides |
| GroES-like | 0.1447 | INHERITED FROM: Naphthols || Benz(a)Anthracenes || apocarotenal || walrycin A |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0.1447 | INHERITED FROM: tamibarotene || Estradiol |
| UDP-Glycosyltransferase/glycogen phosphorylase | 0.1455 | INHERITED FROM: Naphthols || Estrone || Morphine || 1,2,5,8-tetrahydroxy anthraquinone || 3-hydroxydesloratadine || 2,6-dihydroxyanthraquinone || Phenanthrenes || 1-hydroxypyrene || alizarin || Bile Acids and Salts || dibenzo(a,l)pyrene || ranirestat || 2-hydroxyestradiol || shikonin || Anthracenes || plumbagin || 1,4-dihydroxyanthraquinone || Loratadine || Cholanes || Hydroxyestrones || 1-naphthol || Benz(a)Anthracenes || Cholic Acids || Naproxen || Dibenzocycloheptenes || Anthraquinones || Ketosteroids || Naphthaleneacetic Acids || 2-Methoxyestradiol || Pregnenolone Carbonitrile || Methylcholanthrene || anthrarobin || Benzocycloheptenes || Cyproheptadine || Androsterone || Pregnenolone || Estriol || Morphinans || 4-hydroxyestrone || Cyclohexanecarboxylic Acids || sulindac sulfone || alloin || Spiro Compounds || Anthralin || Deoxycholic Acid || Morphine Derivatives |
| Frizzled cysteine-rich domain | 0.1607 | INHERITED FROM: Mifepristone || Tretinoin || Cyclohexanes || Pregnadienetriols || Dexamethasone || Vitamin A |
| Nucleic acid-binding proteins | 0.1637 | INHERITED FROM: CD 437 || beauvericin || Sesquiterpenes, Eudesmane || Thapsigargin || Bridged-Ring Compounds || Quinic Acid || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Polycyclic Sesquiterpenes || Sesquiterpenes, Guaiane || Adamantane || Cycloheptanes |
| FnI-like domain | 0.1678 | INHERITED FROM: Pregnenediones || Tetrapyrroles || Lovastatin || Norsteroids || Simvastatin || Prednisolone || Pregnadienetriols |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.178 | INHERITED FROM: Tacrolimus |
| Riboflavin synthase domain-like | 0.178 | INHERITED FROM: Tacrolimus |
| Cupredoxins | 0.178 | INHERITED FROM: Desogestrel || Norpregnatrienes || ethinyl estradiol-desogestrel combination |
| PGBD-like | 0.178 | INHERITED FROM: Ouabain || mibolerone || Mifepristone || pyrazolanthrone || manganese(III)-tetrakis(4-benzoic acid)porphyrin || Chlorogenic Acid || cyclo(Trp-Asp-Pro-Val-Leu) || 1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one || Pregnenediones || Hydroxycholecalciferols || Dihydroxycholecalciferols || Tetrapyrroles || Lovastatin || Anthracenes || Nandrolone || Calcitriol || Estradiol || Sterols || Simvastatin || Wortmannin || Paclitaxel || Doxycycline || Cyclodecanes || 3-caffeoyl-4-dihydrocaffeoylquinic acid || Cardanolides || Porphyrins || Tetracyclines || Progesterone || Cardiac Glycosides || bufalin || Cyclohexanecarboxylic Acids || Spiro Compounds || Cholestenes |
| SNF-like | 0.178 | INHERITED FROM: Indans || Cyclohexanones || 2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone || indatraline || Cyclohexylamines |
| RNA-binding domain, RBD | 0.1865 | INHERITED FROM: 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol || Dihydroxydihydrobenzopyrenes || yessotoxin || 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide || pateamine A |
| SMAD/FHA domain | 0.1871 | INHERITED FROM: sirtinol || aucubin || Iridoid Glucosides || Benzopyrenes || Iridoids || Aristolochic Acids || Iridoid Glycosides |
| Leucine zipper domain | 0.1871 | INHERITED FROM: Retinoids || Cyclosporins || SR 144528 || Sesquiterpenes, Eudesmane || Bile Acids and Salts || tauroursodeoxycholic acid || 1-Naphthylamine || Pregnenediones || Brefeldin A || Tetrapyrroles || Thapsigargin || Anthracenes || Bridged-Ring Compounds || Cholanes || Estradiol || 1-nitropyrene || Cholic Acids || Hemin || Norpregnatrienes || diphenylcyclopropenone || Sulindac || Camphanes || Macrocyclic Compounds || cyanoginosin LR || Polycyclic Sesquiterpenes || Withanolides || Sesquiterpenes, Guaiane || nodularin || 9,10-dihydro-9,10-dihydroxybenzo(a)pyrene || withaferin A || Trichothecenes || Cycloheptanes || Cyclohexenes || Naphthalenes || Cholestenes || Sertraline |
| Cyclin-like | 0.196 | INHERITED FROM: Ursodeoxycholic Acid || tylophorine || HS 1030 || apicidin || Steroids, Heterocyclic || HS 1200 || seocalcitol || Indenes || Wortmannin || Paclitaxel || Polyketides || Brassinosteroids || Sulindac || brassinolide || Fulvestrant || Cyclodecanes || 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid || HS 1183 || Cardenolides || AGN 194204 || 2-Methoxyestradiol || LG 100268 || Phytosterols || Ethers, Cyclic || HS-1199 || inecalcitol |
| Thioredoxin-like | 0.1972 | INHERITED FROM: dichlone || Bile Acids and Salts || dibenzo(a,l)pyrene || Tetrapyrroles || microcystin RR || beta Carotene || Chlorophyllides || Quinic Acid || apocarotenal || 17-Ketosteroids || Ketosteroids || Macrocyclic Compounds || captafol || Bile Pigments || Microcystins |
| DBL homology domain (DH-domain) | 0.2179 | INHERITED FROM: Hydroxycholecalciferols || Dihydroxycholecalciferols || Calcitriol || Cholecalciferol || benzo(e)pyrene |
| SNARE-like | 0.2333 | INHERITED FROM: yessotoxin |
| DEATH domain | 0.2362 | INHERITED FROM: Macrolides || methyl 5-chloro-4,5-didehydrojasmonate || Pyrethrins || tylophorine || cinobufotalin || Menthol || Cyclohexanols || Diosgenin || Cyclohexane Monoterpenes || Phenanthrenes || indioside D || Bile Acids and Salts || tauroursodeoxycholic acid || Dactinomycin || Tetrapyrroles || Anthracenes || Bridged-Ring Compounds || beta Carotene || Cholanes || Fenretinide || 4-(3-(1-adamantyl)-4-hydroxyphenyl)-3-chlorocinnamic acid || Cholic Acids || Cholestanes || dehydroxymethylepoxyquinomicin || Epichlorohydrin || aloe emodin || Anthraquinones || bis(acetato)(1-adamantylamine)amminedichloroplatinum(IV) || Polyketides || Sulindac || Cyclodecanes || Digitoxin || Cycloparaffins || pregna-4,17-diene-3,16-dione || Spirostans || Win 55212-2 || Taxoids || Porphyrins || cypermethrin || Cyclohexanones || Acitretin || nodularin || Ethers, Cyclic || Nystatin || 2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyc || Oxocins || brevetoxin 2 || Aclarubicin || Depsipeptides |
| Histone-fold | 0.2365 | INHERITED FROM: Naphthoquinones || Ergocalciferols || MT19c compound |
| DNA/RNA polymerases | 0.2418 | INHERITED FROM: diepoxybutane || Phenalenes || Benz(a)Anthracenes || Epoxy Compounds || Perylene |
| Periplasmic binding protein-like I | 0.2427 | INHERITED FROM: Dizocilpine Maleate || Dibenzocycloheptenes |
| vWA-like | 0.2484 | INHERITED FROM: Pregnenes || Pregnenediones || Medroxyprogesterone || Medroxyprogesterone Acetate || Cyclodecanes |
| Calcium ATPase, transmembrane domain M | 0.2604 | INHERITED FROM: Ouabain || Strophanthins || Cardenolides |
| Caspase-like | 0.268 | INHERITED FROM: Macrolides || 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole || Donepezil || methyl 5-chloro-4,5-didehydrojasmonate || Pyrethrins || Glycodeoxycholic Acid || Fused-Ring Compounds || CD 437 || cinobufotalin || Morphine || Menthol || Cyclohexanols || pyrazolanthrone || manganese(III)-tetrakis(4-benzoic acid)porphyrin || Diosgenin || NSC 680410 || Cyclohexane Monoterpenes || 1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one || Phenanthrenes || Sesquiterpenes, Eudesmane || indioside D || Bile Acids and Salts || apicidin || tauroursodeoxycholic acid || Dactinomycin || 1-Naphthylamine || Sapogenins || Hydroxycholecalciferols || Dihydroxycholecalciferols || Amantadine || surfactin peptide || Androstadienes || Lovastatin || diepoxybutane || deoxynivalenol || WP 631 || Anthracenes || Bridged-Ring Compounds || Loratadine || Calcitriol || Epirubicin || Cholanes || Estradiol || 1,4-anthraquinone || Fenretinide || Oleanolic Acid || Epoxy Compounds || methyl protodioscin || Indenes || Cholic Acids || Cholestanes || Wortmannin || dehydroxymethylepoxyquinomicin || Propranolol || Dibenzocycloheptenes || echinocystic acid || Anthraquinones || Polyketides || zinc protoporphyrin || Cyclohexanes || Sulindac || Cyclodecanes || Digitoxin || pregna-4,17-diene-3,16-dione || Spirostans || Bufanolides || Chenodeoxycholic Acid || 2-Methoxyestradiol || Cyclopentanes || alantolactone || Xanthophylls || cobaltiprotoporphyrin || Cardanolides || Win 55212-2 || Taxoids || Ketamine || Benzocycloheptenes || Polycyclic Sesquiterpenes || cypermethrin || Cyproheptadine || Cyclohexanones || Acitretin || Sesquiterpenes, Guaiane || Taurodeoxycholic Acid || Ethers, Cyclic || Taurocholic Acid || bafilomycin A1 || Cardiac Glycosides || 2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyc || Glycocholic Acid || Trichothecenes || Cyclohexanecarboxylic Acids || Cycloheptanes || sulindac sulfide || Taurochenodeoxycholic Acid || Naphthalenes || Spiro Compounds || Depsipeptides || Deoxycholic Acid || Morphine Derivatives || Sertraline |
| (Phosphotyrosine protein) phosphatases II | 0.2703 | INHERITED FROM: Benzo(a)pyrene || Sertraline |
| Toll/Interleukin receptor TIR domain | 0.2741 | INHERITED FROM: 9,10-dihydro-2,5-dimethoxyphenanthrene-1,7-diol || Paclitaxel || Cyclodecanes || Ivermectin |
| Kringle-like | 0.2741 | INHERITED FROM: Ouabain || genipin || Gestodene || Beclomethasone || Dactinomycin || Tetrapyrroles || Medroxyprogesterone || Oleanolic Acid || Medroxyprogesterone Acetate || Simvastatin || Propranolol || Hydroxyprogesterones || alpha-benzoylamino-1,4-naphthoquinone || Strophanthins || Porphyrins || Iridoids || Progesterone || Norpregnenes || ethinyl estradiol-desogestrel combination |
| Serpins | 0.2787 | INHERITED FROM: 2,3-dimethoxy-1,4-naphthoquinone || Hydroxycholecalciferols || Dihydroxycholecalciferols || Calcitriol || Norsteroids || Cholic Acids || Rifampin || ethinyl estradiol-desogestrel combination || Estranes || Cholestenes |
| Calcium ATPase, transduction domain A | 0.2787 | INHERITED FROM: Ouabain || Strophanthins || Cardenolides |
| GLA-domain | 0.2956 | INHERITED FROM: Gestodene || Pregnenediones || Medroxyprogesterone || estradiol, norethindrone drug combination || Nandrolone || norgestimate, ethinyl estradiol drug combination || dienogest || Norsteroids || Medroxyprogesterone Acetate || Norpregnatrienes || Norpregnenes || estradiol valerate-dienogest || ethinyl estradiol-desogestrel combination |
| Class II aaRS and biotin synthetases | 0.2961 | INHERITED FROM: Sesquiterpenes, Eudesmane || Thapsigargin || Sesquiterpenes, Guaiane || Cycloheptanes |
| Tubulin nucleotide-binding domain-like | 0.3203 | INHERITED FROM: Sesquiterpenes, Eudesmane || 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol || dibenzo(a,l)pyrene || Thapsigargin || Polycyclic Sesquiterpenes || Sesquiterpenes, Guaiane |
| Calpain large subunit, middle domain (domain III) | 0.3266 | INHERITED FROM: Menthol || Cyclohexane Monoterpenes || Epoxy Compounds || glycidamide |
| p53-like transcription factors | 0.3279 | INHERITED FROM: Macrolides || benzo(a)pyrene-3,6-quinone || Morphine || Diosgenin || 2-Acetylaminofluorene || Norbornanes || pevonedistat || Dactinomycin || 1-Naphthylamine || Sapogenins || benzo(a)pyrene-1,6-quinone || deoxynivalenol || Bridged-Ring Compounds || Simvastatin || Polyketides || Acenaphthenes || Cyclopentanes || Oxysterols || Cyclohexanones || WP 744 || 2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyc |
| E set domains | 0.3387 | INHERITED FROM: Naphthalenes |
| TRAF domain-like | 0.3442 | INHERITED FROM: Menthol || Cyclohexanols || Cyclohexane Monoterpenes |
| Tubulin C-terminal domain-like | 0.3442 | INHERITED FROM: Sesquiterpenes, Eudesmane || 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol || dibenzo(a,l)pyrene || Thapsigargin || Polycyclic Sesquiterpenes || Sesquiterpenes, Guaiane |
| Aldolase | 0.3595 | INHERITED FROM: obeticholic acid || Cyclosporins || Cholic Acids || Chenodeoxycholic Acid || Peptides, Cyclic || Estranes || Deoxycholic Acid |
| Cystine-knot cytokines | 0.3604 | INHERITED FROM: Plicamycin || Octreotide || Phenanthrenes || Pregnenediones || Pregnadienediols || Estradiol || Simvastatin || Strophanthins || Cardenolides || MOPP protocol || Tetracyclines || Progesterone || Prednisone || aristolochic acid I || Protoporphyrins || Cardiac Glycosides || Oxocins || Digoxigenin |
| MFS general substrate transporter | 0.3815 | INHERITED FROM: Lactams, Macrocyclic || 7-(deoxyguanosin-N(2)-yl)aristolactam I || Estrone || Amitriptyline || Dehydroepiandrosterone || Budesonide || 7-(deoxyadenosin-N(6)-yl)aristolactam I || Nateglinide || Rifamycins || 6-carboxyfluorescein || estradiol-17 beta-glucuronide || Naproxen || Propranolol || Dehydroepiandrosterone Sulfate || Erythromycin || Cholic Acid || Ketosteroids || Naphthaleneacetic Acids || Spironolactone || estrone sulfate || Taurocholic Acid || Rifampin || Estranes |
| CoA-dependent acyltransferases | 0.3961 | INHERITED FROM: Bile Acids and Salts || Cholanes || Cholic Acids || Isotretinoin || Deoxycholic Acid |
| TPR-like | 0.4045 | INHERITED FROM: Cyclosporins |
| Acetyl-CoA synthetase-like | 0.4083 | INHERITED FROM: obeticholic acid || Deoxycholic Acid |
| Nucleotidyltransferase | 0.4281 | INHERITED FROM: Prednisolone || Methylprednisolone |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.4354 | INHERITED FROM: Tetrapyrroles || aurin || Thiostrepton || Polyketides || Porphyrins || Ivermectin || Cyclohexanecarboxylic Acids || Naphthalenes |
| Zn-binding ribosomal proteins | 0.4354 | INHERITED FROM: CD 437 || Bridged-Ring Compounds || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Adamantane |
| Tropomyosin | 0.4585 | INHERITED FROM: Mitoxantrone |
| Cyclophilin-like | 0.4911 | INHERITED FROM: yessotoxin || Oxocins |
| NAD(P)-linked oxidoreductase | 0.5255 | INHERITED FROM: 9,10-phenanthrenequinone || Pregnanolone || benzo(a)pyrene-3,6-quinone || Estrone || acenaphthene-1-ol || Retinaldehyde || Phenanthrenes || Hydroxysteroids || benzo(a)pyrene-7,8-dione || Bile Acids and Salts || Pregnanediones || dibenzo(a,l)pyrene || Medroxyprogesterone || benzo(a)pyrene-1,6-quinone || tetralol || Steroids, Heterocyclic || 4-hydroxyequilenin-o-quinone || Dydrogesterone || Cholanes || Tetralones || Benz(a)Anthracenes || Indenes || 3-nitrobenzanthrone || Cholic Acids || Medroxyprogesterone Acetate || 9-cis-retinal || 1,2-naphthoquinone || Naproxen || 3-aminobenzanthrone || tetrahydrodeoxycorticosterone || 16-ketoestrone || cyclopentanone || daunorubicinol || Ketosteroids || Corticosterone || Naphthaleneacetic Acids || Acenaphthenes || N-hydroxy-3-aminobenzanthrone || Chrysenes || Ethers, Cyclic || 9,10-dihydro-9,10-dihydroxybenzo(a)pyrene || benzo(a)pyrene 7,8-dihydrodiol || glycidamide || Desoxycorticosterone || Equilenin || Azasteroids || cyclopentanol || 20-alpha-Dihydroprogesterone || Fluorenes || Naphthalenes || Dutasteride || Deoxycholic Acid || 5-alpha-Dihydroprogesterone |
| A DNA-binding domain in eukaryotic transcription factors | 0.5598 | INHERITED FROM: obeticholic acid || Bile Acids and Salts || 1-Naphthylamine || Tetrapyrroles || deoxynivalenol || Tretinoin || Cholanes || Epoxy Compounds || Cholic Acids || Hemin || Vitamin K 3 || 9,10-dihydro-9,10-dihydroxybenzo(a)pyrene || Vitamin K || Trichothecenes || Vitamin A || Deoxycholic Acid || Sertraline |
| Ferritin-like | 0.5772 | INHERITED FROM: Paclitaxel || Cyclodecanes |
| LuxS/MPP-like metallohydrolase | 0.5772 | INHERITED FROM: Isotretinoin |
| Plakin repeat | 0.5772 | INHERITED FROM: Hydroxycholecalciferols || Dihydroxycholecalciferols || Calcitriol || Cholecalciferol |
| (Trans)glycosidases | 0.6173 | INHERITED FROM: yessotoxin || Oxocins |
| Polo-box domain | 0.6347 | INHERITED FROM: Dihydroxydihydrobenzopyrenes || 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
| GroEL equatorial domain-like | 0.6359 | INHERITED FROM: CD 437 || Okadaic Acid || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Ivermectin || Adamantane |
| GroEL apical domain-like | 0.6359 | INHERITED FROM: CD 437 || Okadaic Acid || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Ivermectin || Adamantane |
| PAP/OAS1 substrate-binding domain | 0.6359 | INHERITED FROM: Prednisolone || Methylprednisolone |
| MHC antigen-recognition domain | 0.6496 | INHERITED FROM: Minocycline || tamibarotene || Erythromycin || Tetrahydronaphthalenes || Tetracyclines || Naphthalenes |
| Multidrug efflux transporter AcrB transmembrane domain | 0.7159 | INHERITED FROM: Cholesterol |
| GroEL-intermediate domain like | 0.7159 | INHERITED FROM: CD 437 || Okadaic Acid || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Ivermectin || Adamantane |
| "Winged helix" DNA-binding domain | 0.7382 | INHERITED FROM: mibolerone |
| Nucleoside diphosphate kinase, NDK | 0.7578 | INHERITED FROM: Menthol || Cyclohexane Monoterpenes |
| alpha/beta-Hydrolases | 0.762 | INHERITED FROM: 6-O-monoacetylmorphine || Heroin || Morphine Derivatives |
| CCCH zinc finger | 0.7925 | INHERITED FROM: 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol |
| Flavoproteins | 0.7977 | INHERITED FROM: Mifepristone || Phenanthrenes || Tetrapyrroles || Simvastatin || Wortmannin || Polyketides || Porphyrins || Fluorenes |
| Lipocalins | 0.8151 | INHERITED FROM: 1-anilino-8-naphthalenesulfonate || 11-(dansylamino)undecanoic acid || 4-oxoretinoic acid || Dansyl Compounds || Naphthalenesulfonates || Anilino Naphthalenesulfonates |
| ClpP/crotonase | 0.8176 | INHERITED FROM: Isotretinoin |
| Translation proteins | 0.8374 | INHERITED FROM: Metribolone |
| E2F-DP heterodimerization region | 0.8386 | INHERITED FROM: Menthol || Cyclohexanols || Cyclohexane Monoterpenes || Paclitaxel |
| Kazal-type serine protease inhibitors | 0.8665 | INHERITED FROM: estrone sulfate |
| Voltage-gated potassium channels | 0.9107 | INHERITED FROM: Mibefradil |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.912 | INHERITED FROM: Pregnanolone || carvone || tetramethylenedisulfotetramine || Camphor || menthone || 13-desmethylspirolide C || Bridged-Ring Compounds || 13,19-didesmethyl spirolide C || N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline || Rocuronium || Picrotoxin || isoborneol || Pancuronium || Vecuronium Bromide || beta-thujone |
| Nicotinic receptor ligand binding domain-like | 0.912 | INHERITED FROM: Pregnanolone || carvone || tetramethylenedisulfotetramine || Camphor || menthone || 13-desmethylspirolide C || Bridged-Ring Compounds || 13,19-didesmethyl spirolide C || N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline || Rocuronium || Picrotoxin || isoborneol || Pancuronium || Vecuronium Bromide || beta-thujone |
| Actin-like ATPase domain | 0.9246 | INHERITED FROM: aurin || Thiostrepton || Hemin || Ivermectin |
| Prefoldin | 0.9395 | INHERITED FROM: Alitretinoin || 4-oxoretinoic acid || beta Carotene || Bexarotene || 4-oxoretinol || ethyl-p-((E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-1-propenyl)benzoic acid |
| BPTI-like | 0.9574 | INHERITED FROM: Paclitaxel || Cyclodecanes |
| TNF-like | 0.9711 | INHERITED FROM: Menthol || Cyclohexanols || Plicamycin || Cyclohexane Monoterpenes || Lovastatin || Medroxyprogesterone Acetate || Hydroxyprogesterones || aloe emodin || brevetoxin 2 |
| Cytokine | 0.9845 | INHERITED FROM: Cholesterol || Suramin || Steroids, Chlorinated || Beclomethasone || Anthracenes || 1-nitropyrene || Naphthalenesulfonates |
| Insulin-like | 0.9869 | INHERITED FROM: Testosterone || Androstenols || Androstanes || Norgestrel || Norsteroids || Wortmannin || Androstenes || Hydrocortisone |
| TK C-terminal domain-like | 0.9893 | INHERITED FROM: Isotretinoin |
| Cadherin-like | 0.9928 | INHERITED FROM: dibenzo(a,l)pyrene || jasplakinolide |
| Fibrinogen C-terminal domain-like | 0.9951 | INHERITED FROM: Gestodene || Norethindrone || Desogestrel || Nandrolone || dienogest || azaspiracid || norgestimate || estradiol valerate-dienogest || ethinyl estradiol-desogestrel combination |
| Trypsin-like serine proteases | 1 | INHERITED FROM: NuvaRing || Gestodene || Norethindrone || Medroxyprogesterone || estradiol, norethindrone drug combination || Nandrolone || Medroxyprogesterone Acetate || Norpregnatrienes || norgestimate || Azasteroids || estradiol valerate-dienogest || ethinyl estradiol-desogestrel combination || Dutasteride |
| Chaperone J-domain | 1 | INHERITED FROM: Carbaryl || motexafin gadolinium |
| HLH, helix-loop-helix DNA-binding domain | 1 | INHERITED FROM: testosterone-3-carboxymethyloxime-bovine serum albumin conjugate || eldecalcitol || dihydroxy-vitamin D3 || azaspiracid || Rifampin || Dihydrotestosterone |
| Family A G protein-coupled receptor-like | 1 | INHERITED FROM: 2-(beta-(3-iodo-4-hydroxyphenyl)ethylaminomethyl)tetralone || 8-Hydroxy-2-(di-n-propylamino)tetralin || Sapogenins || Oleanolic Acid || Rocuronium || methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate || Spiperone || oleandrin || Pancuronium |
| 4-helical cytokines | 1 | INHERITED FROM: Cholesterol || Pregnenes || Steroids, Chlorinated || SR 144528 || FEC protocol || Phenanthrenes || Budesonide || Beclomethasone || Norbornanes || Dactinomycin || Pregnenediones || Alitretinoin || Pregnadienediols || Tetrapyrroles || Medroxyprogesterone || Androstanes || Androstadienes || Dydrogesterone || Lovastatin || deoxynivalenol || Anthracenes || Cholestenones || Clarithromycin || Epirubicin || Betamethasone Valerate || Medroxyprogesterone Acetate || Simvastatin || Prednisolone || Dibenzocycloheptenes || Androstenes || Polyketides || alclometasone dipropionate || apocarotenal || Camphanes || Betamethasone || Cilomilast || helenalin || primycin || Spironolactone || Benzocycloheptenes || Ergosterol || Withanolides || Phytosterols || Ethers, Cyclic || Methylprednisolone || Trichothecenes || Oxocins || Morphinans || brevetoxin 2 || Cyclohexanecarboxylic Acids || Hydrocortisone || coagulin-L || paricalcitol |
| Intermediate filament protein, coiled coil region | 1 | INHERITED FROM: Alitretinoin || 4-oxoretinoic acid || beta Carotene || calcipotriene || 4-oxoretinol || ethyl-p-((E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-1-propenyl)benzoic acid || Microcystins || Isotretinoin |
| Immunoglobulin | 1 | INHERITED FROM: 24,25-epoxycholesterol || 5H-benzo(4,5)cyclohepta(1,2-b)pyridin-5-one || helenalin |
| Homeodomain-like | 1 | INHERITED FROM: beta Carotene || apocarotenal |
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| DNA-glycosylase | 0 | Direct |
| Families 57/38 glycoside transferase middle domain | 0 | Direct |
| ValRS/IleRS/LeuRS editing domain | 0 | Direct |
| occludin/ELL-like | 0 | Direct |
| CAD & PB1 domains | 0 | Direct |
| Adenine nucleotide alpha hydrolases-like | 0 | Direct |
| PIN domain-like | 0 | Direct |
| MIR domain | 0 | Direct |
| Calcium-dependent phosphotriesterase | 0 | Direct |
| Serum albumin-like | 0 | Direct |
| BTG domain-like | 0 | Direct |
| BolA-like | 0 | Direct |
| PRC-barrel domain | 0 | Direct |
| Bacterial exopeptidase dimerisation domain | 0 | Direct |
| Ribosomal protein L30p/L7e | 0 | Direct |
| Class I glutamine amidotransferase-like | 0 | Direct |
| DEK C-terminal domain | 0 | Direct |
| GYF domain | 0 | Direct |
| Alpha-macroglobulin receptor domain | 0 | Direct |
| BAG domain | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
| Formate/glycerate dehydrogenase catalytic domain-like | 0 | Direct |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
| Cation efflux protein transmembrane domain-like | 0 | Direct |
| Purine and uridine phosphorylases | 0 | Direct |
| GINS helical bundle-like | 0 | Direct |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | Direct |
| Mediator hinge subcomplex-like | 0 | Direct |
| AN1-like Zinc finger | 0 | Direct |
| SIS domain | 0 | Direct |
| Di-copper centre-containing domain | 0 | Direct |
| EB1 dimerisation domain-like | 0 | Direct |
| CCHHC domain | 0 | Direct |
| DUSP-like | 0 | Direct |
| Inosine monophosphate dehydrogenase (IMPDH) | 0 | Direct |
| G protein-binding domain | 0 | Direct |
| beta-lactamase/transpeptidase-like | 0 | Direct |
| Alpha-L RNA-binding motif | 0 | Direct |
| Ribonuclease PH domain 2-like | 0 | Direct |
| LeuD/IlvD-like | 0 | Direct |
| 2Fe-2S ferredoxin-like | 0 | Direct |
| Protein prenylyltransferase | 0 | Direct |
| GHMP Kinase, C-terminal domain | 0 | Direct |
| F1F0 ATP synthase subunit C | 0 | Direct |
| Thyroglobulin type-1 domain | 0 | Direct |
| Nucleotide-binding domain | 0 | Direct |
| ARID-like | 0 | Direct |
| Peptidase/esterase 'gauge' domain | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | Direct |
| FAD-dependent thiol oxidase | 0 | Direct |
| PAH2 domain | 0 | Direct |
| Carbohydrate phosphatase | 0 | Direct |
| Formyltransferase | 0 | Direct |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
| I/LWEQ domain | 0 | Direct |
| Domain of poly(ADP-ribose) polymerase | 0 | Direct |
| Aminomethyltransferase beta-barrel domain | 0 | Direct |
| FF domain | 0 | Direct |
| N-(deoxy)ribosyltransferase-like | 0 | Direct |
| FMN-linked oxidoreductases | 0 | Direct |
| PAZ domain | 0 | Direct |
| Phosphoglucomutase, C-terminal domain | 0 | Direct |
| LCCL domain | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| EPT/RTPC-like | 0 | Direct |
| Cytochrome b5-like heme/steroid binding domain | 0 | Direct |
| Trimeric LpxA-like enzymes | 0 | Direct |
| Cation efflux protein cytoplasmic domain-like | 0 | Direct |
| Troponin coil-coiled subunits | 0 | Direct |
| Lipoxigenase | 0 | Direct |
| Glutamine synthetase/guanido kinase | 0 | Direct |
| MAPEG domain-like | 0 | Direct |
| MOSC N-terminal domain-like | 0 | Direct |
| AXH domain | 0 | Direct |
| C-terminal domain of adenylylcyclase associated protein | 0 | Direct |
| PUG domain-like | 0 | Direct |
| Thiolase-like | 0 | Direct |
| PHM/PNGase F | 0 | Direct |
| Nucleoplasmin-like core domain | 0 | Direct |
| Arginase/deacetylase | 0 | Direct |
| P-domain of calnexin/calreticulin | 0 | Direct |
| AhpD-like | 0 | Direct |
| LanC-like | 0 | Direct |
| Sema domain | 0 | Direct |
| BRK domain-like | 0 | Direct |
| Pseudouridine synthase | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| MgtE membrane domain-like | 0 | Direct |
| Amidase signature (AS) enzymes | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| Peptidylarginine deiminase Pad4, middle domain | 0 | Direct |
| ClpS-like | 0 | Direct |
| Indolic compounds 2,3-dioxygenase-like | 0 | Direct |
| MIT domain | 0 | Direct |
| Nicotinate/Quinolinate PRTase C-terminal domain-like | 0 | Direct |
| ISP domain | 0 | Direct |
| Carbon-nitrogen hydrolase | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | Direct |
| Uracil-DNA glycosylase-like | 0 | Direct |
| Rudiment single hybrid motif | 0 | Direct |
| Phosphoglycerate mutase-like | 0 | Direct |
| Anaphylotoxins (complement system) | 0 | Direct |
| Nop domain | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| FAD-binding/transporter-associated domain-like | 0 | Direct |
| S13-like H2TH domain | 0 | Direct |
| Metallothionein | 0 | Direct |
| Stathmin | 0 | Direct |
| Phosphoenolpyruvate/pyruvate domain | 0 | Direct |
| Periplasmic binding protein-like II | 0 | Direct |
| Clathrin adaptor appendage domain | 0 | Direct |
| YWTD domain | 0 | Direct |
| PEBP-like | 0 | Direct |
| Glycoside hydrolase/deacetylase | 0 | Direct |
| SGNH hydrolase | 0 | Direct |
| Release factor | 0 | Direct |
| ADP-ribosylglycohydrolase | 0 | Direct |
| TB module/8-cys domain | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| Assembly domain of cartilage oligomeric matrix protein | 0 | Direct |
| Ribosomal L27 protein-like | 0 | Direct |
| TSP type-3 repeat | 0 | Direct |
| JAB1/MPN domain | 0 | Direct |
| FAD-linked oxidases, C-terminal domain | 0 | Direct |
| ITPase-like | 0 | Direct |
| Plexin repeat | 0 | Direct |
| FMT C-terminal domain-like | 0 | Direct |
| Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain | 0 | Direct |
| Alanine racemase C-terminal domain-like | 0 | Direct |
| DHS-like NAD/FAD-binding domain | 0 | Direct |
| HR1 repeat | 0 | Direct |
| RmlC-like cupins | 0 | Direct |
| Gamma-glutamyl cyclotransferase-like | 0 | Direct |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
| TAFH domain-like | 0 | Direct |
| BRCT domain | 0 | Direct |
| PLP-binding barrel | 0 | Direct |
| ATP-dependent DNA ligase DNA-binding domain | 0 | Direct |
| SCP-like | 0 | Direct |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
| AlbA-like | 0 | Direct |
| R3H domain | 0 | Direct |
| beta-sandwich domain of Sec23/24 | 0 | Direct |
| DNA polymerase beta, N-terminal domain-like | 0 | Direct |
| FMN-binding split barrel | 0 | Direct |
| Phosphofructokinase | 0 | Direct |
| GTF2I-like repeat | 0 | Direct |
| BSD domain-like | 0 | Direct |
| Aconitase iron-sulfur domain | 0 | Direct |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | Direct |
| Clc chloride channel | 0 | Direct |
| Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain | 0 | Direct |
| Heme-dependent peroxidases | 0 | Direct |
| Bcl-2 inhibitors of programmed cell death | 0 | Direct |
| Eferin C-derminal domain-like | 0 | Direct |
| Microbial and mitochondrial ADK, insert "zinc finger" domain | 0 | Direct |
| HSP40/DnaJ peptide-binding domain | 0 | Direct |
| VHP, Villin headpiece domain | 0 | Direct |
| Integrin beta tail domain | 0 | Direct |
| Subtilisin-like | 0 | Direct |
| PK beta-barrel domain-like | 0 | Direct |
| Guanido kinase N-terminal domain | 0 | Direct |
| LysM domain | 0 | Direct |
| Proteasome activator | 0 | Direct |
| 4Fe-4S ferredoxins | 0 | Direct |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
| N-terminal domain of cbl (N-cbl) | 0 | Direct |
| BEACH domain | 0 | Direct |
| Fe-S cluster assembly (FSCA) domain-like | 0 | Direct |
| PurM N-terminal domain-like | 0 | Direct |
| Acyl-CoA dehydrogenase NM domain-like | 0 | Direct |
| Endosomal sorting complex assembly domain | 0 | Direct |
| Six-hairpin glycosidases | 0 | Direct |
| WGR domain-like | 0 | Direct |
| Putative isomerase YbhE | 0 | Direct |
| A heparin-binding domain | 0 | Direct |
| Fibrinogen coiled-coil and central regions | 0 | Direct |
| KA1-like | 0 | Direct |
| FKBP-like | 0 | Direct |
| Hect, E3 ligase catalytic domain | 0 | Direct |
| Apolipoprotein A-I | 0 | Direct |
| RBP11-like subunits of RNA polymerase | 0 | Direct |
| Succinyl-CoA synthetase domains | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Transcription factor IIA (TFIIA), alpha-helical domain | 0 | Direct |
| Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | Direct |
| Leukotriene A4 hydrolase N-terminal domain | 0 | Direct |
| Sec7 domain | 0 | Direct |
| PWI domain | 0 | Direct |
| Proton glutamate symport protein | 0 | Direct |
| Probable bacterial effector-binding domain | 0 | Direct |
| Transcription factor IIA (TFIIA), beta-barrel domain | 0 | Direct |
| p53 tetramerization domain | 0 | Direct |
| IP3 receptor type 1 binding core, domain 2 | 0 | Direct |
| Oxysterol-binding protein-like | 0 | Direct |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | Direct |
| His-Me finger endonucleases | 0 | Direct |
| Mitochondrial cytochrome c oxidase subunit VIIa | 0 | Direct |
| Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
| DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
| MAST3 pre-PK domain-like | 0 | Direct |
| GFP-like | 0 | Direct |
| Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
| RGC domain-like | 0 | Direct |
| PriA/YqbF domain | 0 | Direct |
| Methylglyoxal synthase-like | 0 | Direct |
| Chicken cartilage matrix protein | 0 | Direct |
| alpha/beta knot | 0 | Direct |
| Nucleoporin domain | 0 | Direct |
| alpha-catenin/vinculin-like | 0 | Direct |
| Pentein | 0 | Direct |
| Ribosomal protein L1 | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
| Ribosomal protein S10 | 0 | Direct |
| DLC | 0 | Direct |
| Serine protease inhibitors | 0 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
| Transferrin receptor-like dimerisation domain | 0 | Direct |
| Delta-sleep-inducing peptide immunoreactive peptide | 0 | Direct |
| PABC (PABP) domain | 0 | Direct |
| Actin-crosslinking proteins | 0 | Direct |
| Amine oxidase N-terminal region | 0 | Direct |
| STAT | 0 | Direct |
| ALDH-like | 0 | Direct |
| Connexin43 | 0 | Direct |
| ABC transporter transmembrane region | 0 | Direct |
| Galactose mutarotase-like | 0 | Direct |
| Amine oxidase catalytic domain | 0 | Direct |
| YVTN repeat-like/Quinoprotein amine dehydrogenase | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Ribosomal protein S18 | 0 | Direct |
| 3-carboxy-cis,cis-mucoante lactonizing enzyme | 0 | Direct |
| Restriction endonuclease-like | 0 | Direct |
| SPOC domain-like | 0 | Direct |
| Seven-hairpin glycosidases | 0 | Direct |
| Single hybrid motif | 0 | Direct |
| Glycolipid transfer protein, GLTP | 0 | Direct |
| Terpenoid cyclases/Protein prenyltransferases | 0 | Direct |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | Direct |
| ACT-like | 0 | Direct |
| Cysteine alpha-hairpin motif | 0 | Direct |
| TIMP-like | 0 | Direct |
| Small-conductance potassium channel | 0 | Direct |
| HIT-like | 0 | Direct |
| Rhodanese/Cell cycle control phosphatase | 0 | Direct |
| PRTase-like | 0 | Direct |
| L27 domain | 0 | Direct |
| C-terminal domain of PLC-beta | 0 | Direct |
| Integrin domains | 0 | Direct |
| Creatinase/prolidase N-terminal domain | 0 | Direct |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | Direct |
| Mss4-like | 0 | Direct |
| USP8 N-terminal domain-like | 0 | Direct |
| Mib/herc2 domain-like | 0 | Direct |
| Mannose 6-phosphate receptor domain | 0 | Direct |
| Nucleotidylyl transferase | 0 | Direct |
| Oncogene products | 0 | Direct |
| S15/NS1 RNA-binding domain | 0 | Direct |
| L-aspartase-like | 0 | Direct |
| Hermes dimerisation domain | 0 | Direct |
| Homocysteine S-methyltransferase | 0 | Direct |
| Activating enzymes of the ubiquitin-like proteins | 0 | Direct |
| Notch domain | 0 | Direct |
| Ribosomal protein L16p/L10e | 0 | Direct |
| Ribosomal proteins S24e, L23 and L15e | 0 | Direct |
| DNA-binding domain | 0 | Direct |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
| FAD-linked oxidoreductase | 0 | Direct |
| Transcription factor STAT-4 N-domain | 0 | Direct |
| AraD/HMP-PK domain-like | 0 | Direct |
| FAD-linked reductases, C-terminal domain | 0 | Direct |
| Class II aaRS ABD-related | 0 | Direct |
| WW domain | 0 | Direct |
| RNase III domain-like | 0 | Direct |
| GAT-like domain | 0 | Direct |
| PapD-like | 0 | Direct |
| Translation proteins SH3-like domain | 0 | Direct |
| Phosphoglucomutase, first 3 domains | 0 | Direct |
| PurM C-terminal domain-like | 0 | Direct |
| Translational machinery components | 0 | Direct |
| VPS9 domain | 0 | Direct |
| P-loop containing nucleoside triphosphate hydrolases | 0.00000007953 | Direct |
| ARM repeat | 0.0000002317 | Direct |
| PH domain-like | 0.000004922 | Direct |
| SH3-domain | 0.00001001 | Direct |
| EGF/Laminin | 0.00007854 | Direct |
| FYVE/PHD zinc finger | 0.0004334 | Direct |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.0005744 | Direct |
| Cytochrome P450 | 0.001792 | Inherited |
| FAD/NAD(P)-binding domain | 0.002629 | Inherited |
| Protein kinase-like (PK-like) | 0.002683 | Inherited |
| PDZ domain-like | 0.002741 | Inherited |
| Growth factor receptor domain | 0.003063 | Inherited |
| Nuclear receptor ligand-binding domain | 0.006347 | Inherited |
| TSP-1 type 1 repeat | 0.007667 | Inherited |
| Ubiquitin-like | 0.007737 | Inherited |
| GTPase activation domain, GAP | 0.007998 | Inherited |
| Metalloproteases ("zincins"), catalytic domain | 0.01 | Inherited |
| Interleukin 8-like chemokines | 0.01038 | Inherited |
| SCOP hierarchy in SUPERFAMILY | 0.01272 | Inherited |
| Bromodomain | 0.01322 | Inherited |
| GST C-terminal domain-like | 0.01895 | Inherited |
| SH2 domain | 0.02657 | Inherited |
| NAD(P)-binding Rossmann-fold domains | 0.02811 | Inherited |
| Second domain of FERM | 0.03394 | Inherited |
| PYP-like sensor domain (PAS domain) | 0.03824 | Inherited |
| Calponin-homology domain, CH-domain | 0.04082 | Inherited |
| Alkaline phosphatase-like | 0.04806 | Inherited |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.0489 | Inherited |
| Mitochondrial carrier | 0.07591 | Inherited |
| Fibronectin type III | 0.07717 | Inherited |
| SNARE fusion complex | 0.08435 | Inherited |
| HD-domain/PDEase-like | 0.09402 | Inherited |
| TNF receptor-like | 0.1049 | Inherited |
| ADP-ribosylation | 0.1049 | Inherited |
| Cysteine-rich domain | 0.1145 | Inherited |
| Integrin alpha N-terminal domain | 0.1169 | Inherited |
| Hemopexin-like domain | 0.1169 | Inherited |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.1292 | Inherited |
| Sm-like ribonucleoproteins | 0.1301 | Inherited |
| Ribosomal protein S5 domain 2-like | 0.1413 | Inherited |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.1413 | Inherited |
| GroES-like | 0.1447 | Inherited |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0.1447 | Inherited |
| UDP-Glycosyltransferase/glycogen phosphorylase | 0.1455 | Inherited |
| Frizzled cysteine-rich domain | 0.1607 | Inherited |
| Nucleic acid-binding proteins | 0.1637 | Inherited |
| FnI-like domain | 0.1678 | Inherited |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.178 | Inherited |
| Riboflavin synthase domain-like | 0.178 | Inherited |
| Cupredoxins | 0.178 | Inherited |
| PGBD-like | 0.178 | Inherited |
| SNF-like | 0.178 | Inherited |
| RNA-binding domain, RBD | 0.1865 | Inherited |
| SMAD/FHA domain | 0.1871 | Inherited |
| Leucine zipper domain | 0.1871 | Inherited |
| Cyclin-like | 0.196 | Inherited |
| Thioredoxin-like | 0.1972 | Inherited |
| DBL homology domain (DH-domain) | 0.2179 | Inherited |
| SNARE-like | 0.2333 | Inherited |
| DEATH domain | 0.2362 | Inherited |
| Histone-fold | 0.2365 | Inherited |
| DNA/RNA polymerases | 0.2418 | Inherited |
| Periplasmic binding protein-like I | 0.2427 | Inherited |
| vWA-like | 0.2484 | Inherited |
| Calcium ATPase, transmembrane domain M | 0.2604 | Inherited |
| Caspase-like | 0.268 | Inherited |
| (Phosphotyrosine protein) phosphatases II | 0.2703 | Inherited |
| Toll/Interleukin receptor TIR domain | 0.2741 | Inherited |
| Kringle-like | 0.2741 | Inherited |
| Serpins | 0.2787 | Inherited |
| Calcium ATPase, transduction domain A | 0.2787 | Inherited |
| GLA-domain | 0.2956 | Inherited |
| Class II aaRS and biotin synthetases | 0.2961 | Inherited |
| Tubulin nucleotide-binding domain-like | 0.3203 | Inherited |
| Calpain large subunit, middle domain (domain III) | 0.3266 | Inherited |
| p53-like transcription factors | 0.3279 | Inherited |
| E set domains | 0.3387 | Inherited |
| TRAF domain-like | 0.3442 | Inherited |
| Tubulin C-terminal domain-like | 0.3442 | Inherited |
| Aldolase | 0.3595 | Inherited |
| Cystine-knot cytokines | 0.3604 | Inherited |
| MFS general substrate transporter | 0.3815 | Inherited |
| CoA-dependent acyltransferases | 0.3961 | Inherited |
| TPR-like | 0.4045 | Inherited |
| Acetyl-CoA synthetase-like | 0.4083 | Inherited |
| Nucleotidyltransferase | 0.4281 | Inherited |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.4354 | Inherited |
| Zn-binding ribosomal proteins | 0.4354 | Inherited |
| Tropomyosin | 0.4585 | Inherited |
| Cyclophilin-like | 0.4911 | Inherited |
| NAD(P)-linked oxidoreductase | 0.5255 | Inherited |
| A DNA-binding domain in eukaryotic transcription factors | 0.5598 | Inherited |
| Ferritin-like | 0.5772 | Inherited |
| LuxS/MPP-like metallohydrolase | 0.5772 | Inherited |
| Plakin repeat | 0.5772 | Inherited |
| (Trans)glycosidases | 0.6173 | Inherited |
| Polo-box domain | 0.6347 | Inherited |
| GroEL equatorial domain-like | 0.6359 | Inherited |
| GroEL apical domain-like | 0.6359 | Inherited |
| PAP/OAS1 substrate-binding domain | 0.6359 | Inherited |
| MHC antigen-recognition domain | 0.6496 | Inherited |
| Multidrug efflux transporter AcrB transmembrane domain | 0.7159 | Inherited |
| GroEL-intermediate domain like | 0.7159 | Inherited |
| "Winged helix" DNA-binding domain | 0.7382 | Inherited |
| Nucleoside diphosphate kinase, NDK | 0.7578 | Inherited |
| alpha/beta-Hydrolases | 0.762 | Inherited |
| CCCH zinc finger | 0.7925 | Inherited |
| Flavoproteins | 0.7977 | Inherited |
| Lipocalins | 0.8151 | Inherited |
| ClpP/crotonase | 0.8176 | Inherited |
| Translation proteins | 0.8374 | Inherited |
| E2F-DP heterodimerization region | 0.8386 | Inherited |
| Kazal-type serine protease inhibitors | 0.8665 | Inherited |
| Voltage-gated potassium channels | 0.9107 | Inherited |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.912 | Inherited |
| Nicotinic receptor ligand binding domain-like | 0.912 | Inherited |
| Actin-like ATPase domain | 0.9246 | Inherited |
| Prefoldin | 0.9395 | Inherited |
| BPTI-like | 0.9574 | Inherited |
| TNF-like | 0.9711 | Inherited |
| Cytokine | 0.9845 | Inherited |
| Insulin-like | 0.9869 | Inherited |
| TK C-terminal domain-like | 0.9893 | Inherited |
| Cadherin-like | 0.9928 | Inherited |
| Fibrinogen C-terminal domain-like | 0.9951 | Inherited |
| Trypsin-like serine proteases | 1 | Inherited |
| Chaperone J-domain | 1 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 1 | Inherited |
| Family A G protein-coupled receptor-like | 1 | Inherited |
| 4-helical cytokines | 1 | Inherited |
| Intermediate filament protein, coiled coil region | 1 | Inherited |
| Immunoglobulin | 1 | Inherited |
| Homeodomain-like | 1 | Inherited |
LINKTO: Domain2BO Download and Domain2BO Algorithm
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Family( show details)
Highlighted in gray are those with FDR_all>0.001
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| beta-CASP RNA-metabolising hydrolases | 0 | DIRECT |
| DNase I-like | 0 | DIRECT |
| JAB1/MPN domain | 0 | DIRECT |
| Protein-L-isoaspartyl O-methyltransferase | 0 | DIRECT |
| Co-chaperone p23-like | 0 | DIRECT |
| RWD domain | 0 | DIRECT |
| Kinase associated domain 1, KA1 | 0 | DIRECT |
| 4HBT-like | 0 | DIRECT |
| Netrin-like domain (NTR/C345C module) | 0 | DIRECT |
| Stathmin | 0 | DIRECT |
| Autophagin-like | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| Diap1 N-terninal region-like | 0 | DIRECT |
| Pentapeptide repeats | 0 | DIRECT |
| Connexin43 | 0 | DIRECT |
| Microbial and mitochondrial ADK, insert "zinc finger" domain | 0 | DIRECT |
| Other IPT/TIG domains | 0 | DIRECT |
| Sir2 family of transcriptional regulators | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | DIRECT |
| C5 cytosine-specific DNA methylase, DCM | 0 | DIRECT |
| Ribonuclease PH domain 1-like | 0 | DIRECT |
| Laminin-type module | 0 | DIRECT |
| Formate/glycerate dehydrogenases, substrate-binding domain | 0 | DIRECT |
| PreBEACH PH-like domain | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| Proprotein convertase P-domain | 0 | DIRECT |
| Release factor | 0 | DIRECT |
| Phosphoribosylpyrophosphate synthetase-like | 0 | DIRECT |
| Oxysterol-binding protein | 0 | DIRECT |
| VPS9 domain | 0 | DIRECT |
| Amine oxidase N-terminal region | 0 | DIRECT |
| TRASH domain | 0 | DIRECT |
| HAT/Suf repeat | 0 | DIRECT |
| FAD-dependent thiol oxidase | 0 | DIRECT |
| Amidase signature (AS) enzymes | 0 | DIRECT |
| Multidomain cupredoxins | 0 | DIRECT |
| Putative glucosidase YicI, domain 3 | 0 | DIRECT |
| BolA-like | 0 | DIRECT |
| Alcohol dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| Proton glutamate symport protein | 0 | DIRECT |
| Alkaline phosphatase | 0 | DIRECT |
| SpoU-like RNA 2'-O ribose methyltransferase | 0 | DIRECT |
| Ribosomal protein L1 | 0 | DIRECT |
| eIF5a N-terminal domain-like | 0 | DIRECT |
| A20-like zinc finger | 0 | DIRECT |
| Plakophilin 1 helical region | 0 | DIRECT |
| Cation efflux protein transmembrane domain-like | 0 | DIRECT |
| Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
| Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains | 0 | DIRECT |
| Class I aldolase | 0 | DIRECT |
| IP3 receptor type 1 binding core, domain 2 | 0 | DIRECT |
| FKBP immunophilin/proline isomerase | 0 | DIRECT |
| 2'-5'-oligoadenylate synthetase 1, OAS1, second domain | 0 | DIRECT |
| AXH domain | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| HEAT repeat | 0 | DIRECT |
| Neurolysin-like | 0 | DIRECT |
| BEACH domain | 0 | DIRECT |
| Eps15 homology domain (EH domain) | 0 | DIRECT |
| Serine carboxypeptidase-like | 0 | DIRECT |
| ALDH-like | 0 | DIRECT |
| Mannose 6-phosphate receptor domain | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | DIRECT |
| IF2B-like | 0 | DIRECT |
| FF domain | 0 | DIRECT |
| RNB domain-like | 0 | DIRECT |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | DIRECT |
| Renal dipeptidase | 0 | DIRECT |
| 2Fe-2S ferredoxin domains from multidomain proteins | 0 | DIRECT |
| LON domain-like | 0 | DIRECT |
| APC10-like | 0 | DIRECT |
| Phenylalanine metabolism regulatory domain | 0 | DIRECT |
| Bacterial PLC | 0 | DIRECT |
| Cytochrome b5 | 0 | DIRECT |
| Inositol monophosphatase/fructose-1,6-bisphosphatase-like | 0 | DIRECT |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
| Chromo barrel domain | 0 | DIRECT |
| Inosine monophosphate dehydrogenase (IMPDH) | 0 | DIRECT |
| Assembly domain of cartilage oligomeric matrix protein | 0 | DIRECT |
| MOSC N-terminal domain-like | 0 | DIRECT |
| Complement components | 0 | DIRECT |
| DNA ligase | 0 | DIRECT |
| Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
| Ribonuclease H | 0 | DIRECT |
| YicI catalytic domain-like | 0 | DIRECT |
| BC C-terminal domain-like | 0 | DIRECT |
| Subtilases | 0 | DIRECT |
| Methyl-CpG-binding domain, MBD | 0 | DIRECT |
| DEATH effector domain, DED | 0 | DIRECT |
| PWI domain | 0 | DIRECT |
| DNA gyrase/MutL, N-terminal domain | 0 | DIRECT |
| D-aminoacid oxidase-like | 0 | DIRECT |
| Integrin domains | 0 | DIRECT |
| Ribosomal protein S10 | 0 | DIRECT |
| Hermes transposase-like | 0 | DIRECT |
| Leukotriene A4 hydrolase catalytic domain | 0 | DIRECT |
| MAPEG domain | 0 | DIRECT |
| S-adenosylhomocystein hydrolase | 0 | DIRECT |
| Lesion bypass DNA polymerase (Y-family), catalytic domain | 0 | DIRECT |
| Histone deacetylase, HDAC | 0 | DIRECT |
| Phosphofructokinase | 0 | DIRECT |
| alpha-catenin/vinculin | 0 | DIRECT |
| MAST3 pre-PK domain-like | 0 | DIRECT |
| WW domain | 0 | DIRECT |
| beta 1,4 galactosyltransferase (b4GalT1) | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
| NagB-like | 0 | DIRECT |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain | 0 | DIRECT |
| Arginase-like amidino hydrolases | 0 | DIRECT |
| PAS domain of steroid receptor coactivator 1A, NCo-A1 | 0 | DIRECT |
| Cyclin A/CDK2-associated p19, Skp2 | 0 | DIRECT |
| Oligoxyloglucan reducing end-specific cellobiohydrolase | 0 | DIRECT |
| Extracellular domain of cell surface receptors | 0 | DIRECT |
| Noncollagenous (NC1) domain of collagen IV | 0 | DIRECT |
| FCH domain | 0 | DIRECT |
| SWIB/MDM2 domain | 0 | DIRECT |
| DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
| Peptidylarginine deiminase Pad4, catalytic C-terminal domain | 0 | DIRECT |
| Peptidylglycine alpha-hydroxylating monooxygenase, PHM | 0 | DIRECT |
| DLC | 0 | DIRECT |
| Mitochondrial cytochrome c oxidase subunit VIIa | 0 | DIRECT |
| P-domain of calnexin/calreticulin | 0 | DIRECT |
| Prokaryotic proteases | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Peptidylarginine deiminase Pad4, middle domain | 0 | DIRECT |
| 2'-5'-oligoadenylate synthetase 1, OAS1, N-terminal domain | 0 | DIRECT |
| GTF2I-like repeat | 0 | DIRECT |
| DNA polymerase III clamp loader subunits, C-terminal domain | 0 | DIRECT |
| STAT | 0 | DIRECT |
| TatD Mg-dependent DNase-like | 0 | DIRECT |
| FucT-like | 0 | DIRECT |
| Enabled/VASP homology 1 domain (EVH1 domain) | 0 | DIRECT |
| Metallothionein | 0 | DIRECT |
| acyl-CoA oxidase C-terminal domains | 0 | DIRECT |
| DEK C-terminal domain | 0 | DIRECT |
| Fascin | 0 | DIRECT |
| Platelet-derived growth factor-like | 0 | DIRECT |
| Pseudouridine synthase RsuA/RluD | 0 | DIRECT |
| Threonyl-tRNA synthetase (ThrRS), second 'additional' domain | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| a tRNA synthase domain | 0 | DIRECT |
| Interferon regulatory factor 3 (IRF3), transactivation domain | 0 | DIRECT |
| Troponin T | 0 | DIRECT |
| Fibrinogen coiled-coil and central regions | 0 | DIRECT |
| Selenoprotein W-related | 0 | DIRECT |
| DEATH domain, DD | 0 | DIRECT |
| PUG domain | 0 | DIRECT |
| Ferredoxin reductase FAD-binding domain-like | 0 | DIRECT |
| FolH catalytic domain-like | 0 | DIRECT |
| Tetrahydrofolate dehydrogenase/cyclohydrolase | 0 | DIRECT |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | DIRECT |
| NOL1/NOP2/sun | 0 | DIRECT |
| Alpha-adaptin ear subdomain-like | 0 | DIRECT |
| Anaphylotoxins (complement system) | 0 | DIRECT |
| Proteasome activator | 0 | DIRECT |
| Phosphatidylethanolamine binding protein | 0 | DIRECT |
| SelR domain | 0 | DIRECT |
| Interferon regulatory factor | 0 | DIRECT |
| Prohormone convertase 1 pro-domain | 0 | DIRECT |
| Flavin-binding PAS domain | 0 | DIRECT |
| Trunk domain of Sec23/24 | 0 | DIRECT |
| Ribosomal proteins L24p and L21e | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| BTG domain-like | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| Transcription factor IIA (TFIIA), beta-barrel domain | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, C-terminal domain | 0 | DIRECT |
| Hect, E3 ligase catalytic domain | 0 | DIRECT |
| Thyroglobulin type-1 domain | 0 | DIRECT |
| Oncogene products | 0 | DIRECT |
| EB1 dimerisation domain-like | 0 | DIRECT |
| PAZ domain | 0 | DIRECT |
| ATP-dependent DNA ligase catalytic domain | 0 | DIRECT |
| Small-conductance potassium channel | 0 | DIRECT |
| CCHHC domain | 0 | DIRECT |
| Pointed domain | 0 | DIRECT |
| PABC (PABP) domain | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| alpha-mannosidase | 0 | DIRECT |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | DIRECT |
| Starch-binding domain | 0 | DIRECT |
| Adenain-like | 0 | DIRECT |
| DUSP, domain in ubiquitin-specific proteases | 0 | DIRECT |
| Integrin beta tail domain | 0 | DIRECT |
| Leukotriene A4 hydrolase C-terminal domain | 0 | DIRECT |
| Ribonuclease PH domain 2-like | 0 | DIRECT |
| Neutral endopeptidase (neprilysin) | 0 | DIRECT |
| RNA editing terminal uridyl transferase 2, RET2, domain 2 | 0 | DIRECT |
| Transcription factor STAT-4 N-domain | 0 | DIRECT |
| beta-sandwich domain of Sec23/24 | 0 | DIRECT |
| Bcl-2 inhibitors of programmed cell death | 0 | DIRECT |
| BC ATP-binding domain-like | 0 | DIRECT |
| LysM domain | 0 | DIRECT |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain | 0 | DIRECT |
| Choline kinase | 0 | DIRECT |
| SPOC domain | 0 | DIRECT |
| p53 DNA-binding domain-like | 0 | DIRECT |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0 | DIRECT |
| Occludin/ELL domain | 0 | DIRECT |
| RNA-polymerase beta | 0 | DIRECT |
| Clathrin heavy-chain linker domain | 0 | DIRECT |
| Apolipoprotein A-I | 0 | DIRECT |
| (Glycosyl)asparaginase | 0 | DIRECT |
| Chicken cartilage matrix protein | 0 | DIRECT |
| Cysteine rich domain | 0 | DIRECT |
| Guanido kinase N-terminal domain | 0 | DIRECT |
| TAFH domain-like | 0 | DIRECT |
| Transferrin | 0 | DIRECT |
| IMD domain | 0 | DIRECT |
| MIF4G domain-like | 0 | DIRECT |
| CAT-like | 0 | DIRECT |
| L27 domain | 0 | DIRECT |
| La domain | 0 | DIRECT |
| Arrestin/Vps26-like | 0 | DIRECT |
| Sedlin (SEDL) | 0 | DIRECT |
| AAT-like | 0 | DIRECT |
| DNA/RNA non-specific endonuclease | 0 | DIRECT |
| Short-chain cytokines | 0 | DIRECT |
| P4 origin-binding domain-like | 0 | DIRECT |
| Troponin I | 0 | DIRECT |
| YWTD domain | 0 | DIRECT |
| HIT (HINT, histidine triad) family of protein kinase-interacting proteins | 0 | DIRECT |
| Sema domain | 0 | DIRECT |
| NagD-like | 0 | DIRECT |
| Adenylyltransferase | 0 | DIRECT |
| Mib/herc2 domain | 0 | DIRECT |
| Osteonectin | 0 | DIRECT |
| Phoshatidylinositol transfer protein, PITP | 0 | DIRECT |
| Delta-sleep-inducing peptide immunoreactive peptide | 0 | DIRECT |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | DIRECT |
| AraD-like aldolase/epimerase | 0 | DIRECT |
| Guanido kinase catalytic domain | 0 | DIRECT |
| BRK domain-like | 0 | DIRECT |
| F1F0 ATP synthase subunit C | 0 | DIRECT |
| Hypoxia-inducible factor HIF ihhibitor (FIH1) | 0 | DIRECT |
| LanC-like | 0 | DIRECT |
| Gelsolin-like | 0 | DIRECT |
| Transcription factor IIA (TFIIA), alpha-helical domain | 0 | DIRECT |
| HtrA-like serine proteases | 0 | DIRECT |
| Cofactor-dependent phosphoglycerate mutase | 0 | DIRECT |
| Anticodon-binding domain | 0 | DIRECT |
| Diacylglycerol kinase-like | 0 | DIRECT |
| GAT domain | 0 | DIRECT |
| Eukaryotic ODC-like | 0 | DIRECT |
| CUE domain | 0 | DIRECT |
| RIKEN cDNA 2310057j16 protein (KIAA1543) | 0 | DIRECT |
| B56-like | 0 | DIRECT |
| Homocysteine S-methyltransferase | 0 | DIRECT |
| Cystathionine synthase-like | 0 | DIRECT |
| MSP-like | 0 | DIRECT |
| Class I glutamine amidotransferases (GAT) | 0 | DIRECT |
| Notch domain | 0 | DIRECT |
| Glycolipid transfer protein, GLTP | 0 | DIRECT |
| Clathrin adaptor core protein | 0 | DIRECT |
| CPH domain | 0 | DIRECT |
| Integrin alpha N-terminal domain | 0 | DIRECT |
| PIWI domain | 0 | DIRECT |
| ABC transporter transmembrane region | 0 | DIRECT |
| LCCL domain | 0 | DIRECT |
| YicI N-terminal domain-like | 0 | DIRECT |
| Protein prenyltransferases | 0 | DIRECT |
| COMT-like | 0 | DIRECT |
| Retinoblastoma tumor suppressor domains | 0 | DIRECT |
| Serum paraoxonase/arylesterase 1, PON1 | 0 | DIRECT |
| Transferrin receptor-like dimerisation domain | 0 | DIRECT |
| PurM C-terminal domain-like | 0 | DIRECT |
| Soluble quinoprotein glucose dehydrogenase | 0 | DIRECT |
| NLI interacting factor-like phosphatase | 0 | DIRECT |
| Alcohol dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| Serum albumin-like | 0 | DIRECT |
| Pumilio repeat | 0 | DIRECT |
| GDI-like N domain | 0 | DIRECT |
| VHP, Villin headpiece domain | 0 | DIRECT |
| Ubiquitin activating enzymes (UBA) | 0 | DIRECT |
| HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
| Kringle modules | 0 | DIRECT |
| Biotin dependent carboxylase carboxyltransferase domain | 0 | DIRECT |
| Rel/Dorsal transcription factors, DNA-binding domain | 0 | DIRECT |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0 | DIRECT |
| Animal lipoxigenases | 0 | DIRECT |
| Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain | 0 | DIRECT |
| Phosphoribulokinase/pantothenate kinase | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Class I alpha-1;2-mannosidase, catalytic domain | 0 | DIRECT |
| VHS domain | 0 | DIRECT |
| GABARAP-like | 0 | DIRECT |
| Glycerol-3-phosphate transporter | 0 | DIRECT |
| 5' to 3' exonuclease catalytic domain | 0 | DIRECT |
| Oligosaccharide phosphorylase | 0 | DIRECT |
| Arylamine N-methyltransferase | 0 | DIRECT |
| Alanine racemase-like, N-terminal domain | 0 | DIRECT |
| PurM N-terminal domain-like | 0 | DIRECT |
| alpha-mannosidase, C-terminal domain | 0 | DIRECT |
| Poly(ADP-ribose) polymerase, C-terminal domain | 0 | DIRECT |
| Peptidylarginine deiminase Pad4, N-terminal domain | 0 | DIRECT |
| L-aminoacid/polyamine oxidase | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| ECR1 N-terminal domain-like | 0 | DIRECT |
| Hexokinase | 0 | DIRECT |
| DNA polymerase beta-like | 0 | DIRECT |
| MATH domain | 0 | DIRECT |
| FMN-linked oxidoreductases | 0 | DIRECT |
| Bacterial exopeptidase dimerisation domain | 0 | DIRECT |
| Macro domain | 0 | DIRECT |
| Histone lysine methyltransferases | 0 | DIRECT |
| Anticodon-binding domain of Class II aaRS | 0 | DIRECT |
| Zf-UBP | 0 | DIRECT |
| Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A | 0 | DIRECT |
| Fumble-like | 0 | DIRECT |
| Pseudouridine synthase II TruB | 0 | DIRECT |
| Isoprenyl diphosphate synthases | 0 | DIRECT |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
| 1,3-glucuronyltransferase | 0 | DIRECT |
| Family 1 of glycosyl hydrolase | 0 | DIRECT |
| RPR domain (SMART 00582 ) | 0 | DIRECT |
| Branched-chain alpha-keto acid dehydrogenase Pyr module | 0 | DIRECT |
| Calnexin/calreticulin | 0 | DIRECT |
| USP8 N-terminal domain-like | 0 | DIRECT |
| Bacterial dinuclear zinc exopeptidases | 0 | DIRECT |
| PNP-oxidase like | 0 | DIRECT |
| GHMP Kinase, N-terminal domain | 0 | DIRECT |
| Formate/glycerate dehydrogenases, NAD-domain | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| Aminoacid dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| Ccg1/TafII250-interacting factor B (Cib) | 0 | DIRECT |
| XPF/Rad1/Mus81 nuclease | 0 | DIRECT |
| PCI domain (PINT motif) | 0 | DIRECT |
| Cytidylyltransferase | 0 | DIRECT |
| N-terminal domain of cbl (N-cbl) | 0 | DIRECT |
| Phosphate binding protein-like | 0 | DIRECT |
| Reductases | 0 | DIRECT |
| N-type ATP pyrophosphatases | 0 | DIRECT |
| Glucose 6-phosphate dehydrogenase-like | 0 | DIRECT |
| L-aspartase/fumarase | 0 | DIRECT |
| beta-glycanases | 0 | DIRECT |
| Variant SAM domain | 0 | DIRECT |
| Hsp90 middle domain | 0 | DIRECT |
| FAD-linked reductases, N-terminal domain | 0 | DIRECT |
| TB module/8-cys domain | 0 | DIRECT |
| acyl-CoA oxidase N-terminal domains | 0 | DIRECT |
| Phosphoribosyltransferases (PRTases) | 0 | DIRECT |
| Nucleoplasmin-like core domain | 0 | DIRECT |
| Purine and uridine phosphorylases | 0 | DIRECT |
| Pseudouridine synthase I TruA | 0 | DIRECT |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
| Nop domain | 0 | DIRECT |
| ARID domain | 0 | DIRECT |
| Sec63 C-terminal domain-like | 0 | DIRECT |
| PB1 domain | 0 | DIRECT |
| Biotinyl/lipoyl-carrier proteins and domains | 0 | DIRECT |
| BSD domain | 0 | DIRECT |
| Steroid-binding domain | 0 | DIRECT |
| WGR domain | 0 | DIRECT |
| LeuD-like | 0 | DIRECT |
| Alpha-macroglobulin receptor domain | 0 | DIRECT |
| SWIRM domain | 0 | DIRECT |
| ValRS/IleRS/LeuRS editing domain | 0 | DIRECT |
| I/LWEQ domain | 0 | DIRECT |
| UBX domain | 0 | DIRECT |
| alpha-mannosidase, domain 2 | 0 | DIRECT |
| Plexin repeat | 0 | DIRECT |
| Thiolase-related | 0 | DIRECT |
| Clc chloride channel | 0 | DIRECT |
| Myeloperoxidase-like | 0 | DIRECT |
| Arfaptin, Rac-binding fragment | 0 | DIRECT |
| Domain G2 of nidogen-1 | 0 | DIRECT |
| Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
| Amine oxidase catalytic domain | 0 | DIRECT |
| Aconitase iron-sulfur domain | 0 | DIRECT |
| Medium chain acyl-CoA dehydrogenase-like, C-terminal domain | 0 | DIRECT |
| SAND domain | 0 | DIRECT |
| Papain-like | 0 | DIRECT |
| Carboxypeptidase regulatory domain | 0 | DIRECT |
| Ferredoxin domains from multidomain proteins | 0 | DIRECT |
| TSP type-3 repeat | 0 | DIRECT |
| Formin homology 2 domain (FH2 domain) | 0 | DIRECT |
| Tissue inhibitor of metalloproteinases, TIMP | 0 | DIRECT |
| Integrin beta EGF-like domains | 0 | DIRECT |
| Ribosomal protein L18 and S11 | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| BC N-terminal domain-like | 0 | DIRECT |
| DNA polymerase I | 0 | DIRECT |
| Ras GEF | 0 | DIRECT |
| SH3BGR (SH3-binding, glutamic acid-rich protein-like) | 0 | DIRECT |
| Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain | 0 | DIRECT |
| Clathrin adaptor appendage, alpha and beta chain-specific domain | 0 | DIRECT |
| Inositol polyphosphate kinase (IPK) | 0 | DIRECT |
| gamma-adaptin C-terminal appendage domain-like | 0 | DIRECT |
| Ribosomal protein S18 | 0 | DIRECT |
| Astacin | 0 | DIRECT |
| Malic enzyme N-domain | 0 | DIRECT |
| Exostosin | 0 | DIRECT |
| Protein prenylyltransferase | 0 | DIRECT |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | DIRECT |
| Histidine acid phosphatase | 0 | DIRECT |
| A heparin-binding domain | 0 | DIRECT |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | DIRECT |
| Filamin repeat (rod domain) | 0 | DIRECT |
| Variant RING domain | 0 | DIRECT |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| HR1 repeat | 0 | DIRECT |
| SMAD domain | 0 | DIRECT |
| RNA methyltransferase FtsJ | 0 | DIRECT |
| HD domain | 0 | DIRECT |
| GYF domain | 0 | DIRECT |
| MIT domain | 0 | DIRECT |
| Scavenger receptor cysteine-rich (SRCR) domain | 0 | DIRECT |
| STAT DNA-binding domain | 0 | DIRECT |
| Eferin C-derminal domain-like | 0 | DIRECT |
| C-terminal domain of PLC-beta | 0 | DIRECT |
| DNA ligase/mRNA capping enzyme postcatalytic domain | 0 | DIRECT |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | DIRECT |
| Glycerophosphoryl diester phosphodiesterase | 0 | DIRECT |
| Class II glutamine amidotransferases | 0 | DIRECT |
| Sterol carrier protein, SCP | 0 | DIRECT |
| Glyoxalase II (hydroxyacylglutathione hydrolase) | 0 | DIRECT |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0 | DIRECT |
| UDP-glucose pyrophosphorylase | 0 | DIRECT |
| DNA polymerase beta, N-terminal domain-like | 0 | DIRECT |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
| MIR domain | 0 | DIRECT |
| RuBisCo LSMT catalytic domain | 0 | DIRECT |
| BAG domain | 0 | DIRECT |
| DNA gyrase/MutL, second domain | 0 | DIRECT |
| MBT repeat | 0 | DIRECT |
| TNF receptor-like | 0 | DIRECT |
| CAD domain | 0 | DIRECT |
| C-terminal domain of adenylylcyclase associated protein | 0 | DIRECT |
| RGC domain | 0 | DIRECT |
| Formyltransferase | 0 | DIRECT |
| Phosphoglucomutase, first 3 domains | 0 | DIRECT |
| Leukotriene A4 hydrolase N-terminal domain | 0 | DIRECT |
| RBP11/RpoL | 0 | DIRECT |
| HCDH C-domain-like | 0 | DIRECT |
| Cell cycle control phosphatase, catalytic domain | 0 | DIRECT |
| R3H domain | 0 | DIRECT |
| Carbamilase | 0 | DIRECT |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
| PAH2 domain | 0 | DIRECT |
| Sec7 domain | 0 | DIRECT |
| Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain | 0 | DIRECT |
| Aminomethyltransferase beta-barrel domain | 0 | DIRECT |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0 | DIRECT |
| AN1-like Zinc finger | 0 | DIRECT |
| Thrombospondin C-terminal domain | 0 | DIRECT |
| SH3-domain | 0.000007989 | DIRECT |
| Tandem AAA-ATPase domain | 0.0009584 | DIRECT |
| EGF-type module | 0.00151 | INHERITED FROM: Retinoids || Chlorogenic Acid || Gestodene || Pregnenediones || Medroxyprogesterone || estradiol, norethindrone drug combination || dienogest || Medroxyprogesterone Acetate || Norpregnatrienes || Methyltestosterone || benzo(e)pyrene || Progesterone || paricalcitol |
| Cytochrome P450 | 0.001572 | INHERITED FROM: S-sulindac || Macrolides || Carbaryl || Naphthols || Lactams, Macrocyclic || pyrene || Indans || Pregnenes || Cyclopentane Monoterpenes || Estrone || Pyrethrins || Fused-Ring Compounds || obeticholic acid || Cholestanols || acenaphthylene || Dehydroepiandrosterone || 1-phenylazo-2-naphthol || 17-alpha-Hydroxyprogesterone || benzo(c)phenanthrene || 1,4-naphthoquinone || Phenanthrenes || decamethrin || 1-chloropyrene || thiocoraline || 4-hydroxyretinoic acid || alizarin || Bile Acids and Salts || Cyclodextrins || 1,3-dinitropyrene || epoxiconazole || 6-methylchrysene || Dactinomycin || 1-Naphthylamine || Pregnenediones || 6-chrysenamine || Clobetasol || 2-hydroxyestradiol || chrysophanic acid || shikonin || Dihydroxycholecalciferols || Androstanes || Cyclobutanes || 2,6-dimethylnaphthalene || Dextrorphan || 2-nitrofluoranthene || phenanthrene || physcione || deoxynivalenol || Anthracenes || 3-methylchrysene || 2-methyl-5-isopropenylcyclohex-2-enone oxime || Loratadine || 4-oxoretinoic acid || Calcitriol || indeno(1,2,3-cd)pyrene || Eucalyptol || Rifamycins || 3,6-dinitrobenzopyrene || Cholanes || 1-naphthol || cyhalothrin || Metalloporphyrins || Phenalenes || Benz(a)Anthracenes || Norsteroids || benzotriphenylene || dibenzoanthracene-3,4-dihydrodiol || Epoxy Compounds || Cholic Acids || Cholestanes || Propranolol || Dibenzocycloheptenes || 6-nitrobenzo(a)pyrene || Hydroxytestosterones || Anthraquinones || naphtho(2,3-a)pyrene || sibutramine || Polyketides || Permethrin || Secosteroids || fenvalerate || Betamethasone || Methyltestosterone || Ketosteroids || naphthalene || purpurin || Acenaphthenes || Cyclopentanes || 4,4'-cyclohexylidenebisphenol || Macrocyclic Compounds || 6-nitrochrysene || UAB 30 || Limonene || triptolide || 9,10-Dimethyl-1,2-benzanthracene || dimemorfan || 9-phenanthrol || trans-1,2-dihydro-1,2-naphthalenediol || Benzocycloheptenes || Dextromethorphan || Ethers, Cyclic || HT-2 toxin || Buspirone || benzo(a)pyrene 7,8-dihydrodiol || 5-methylchrysene || Desoxycorticosterone || Emodin || Trichothecenes || Morphinans || Fluorenes || Naphthalenes || Spiro Compounds || Depsipeptides || 5,12-naphthacenequinone || 4-methylchrysene || Cholestenes || Hydrocortisone || walrycin A || paricalcitol || Sertraline |
| Synaptotagmin-like (S variant) | 0.003898 | INHERITED FROM: Bryostatins |
| BCR-homology GTPase activation domain (BH-domain) | 0.004317 | INHERITED FROM: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
| Pleckstrin-homology domain (PH domain) | 0.004767 | INHERITED FROM: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
| PHD domain | 0.004844 | INHERITED FROM: Dihydroxydihydrobenzopyrenes || 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
| Nuclear receptor ligand-binding domain | 0.005044 | INHERITED FROM: AGN 193109 || Norethindrone Acetate || Toxaphene || Carbaryl || Lactams, Macrocyclic || pyrene || Indans || 2,2-bis(4-glycidyloxyphenyl)propane || Cortodoxone || Cholesterol || Cyclopentane Monoterpenes || Estrone || Pyrethrins || Mifepristone || Fused-Ring Compounds || Retinoids || Bridged Bicyclo Compounds || Equilin || Steroids, Chlorinated || Dehydroepiandrosterone || Valinomycin || Retinaldehyde || Megestrol || Phenanthrenes || Budesonide || 1-hydroxypyrene || Oxymetholone || enzacamene || 4-hydroxyretinoic acid || phantolid || Bile Acids and Salts || Pregnanediones || tibolone || Alitretinoin || 1,1-bis(4-hydroxyphenyl)cyclohexane || Pregnadienediols || Medroxyprogesterone || Androstanes || 3-acetyldeoxynivalenol || Steroids, Heterocyclic || eldecalcitol || Anthracenes || Bridged-Ring Compounds || beta Carotene || Rifamycins || Danazol || tetralin || Epirubicin || calcipotriene || Cholanes || cyhalothrin || Fenretinide || dihydroxy-vitamin D3 || Hydroxycholesterols || Ciclopirox || Indenes || Cholic Acids || Cholestanes || Medroxyprogesterone Acetate || Sterols || Simvastatin || 9-cis-retinal || Prednisolone || phenothrin || 4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid || Bexarotene || Polyketides || Permethrin || Fulvestrant || SR 11237 || fenvalerate || Digitoxin || 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid || Cycloparaffins || Betamethasone || Idarubicin || Ketosteroids || Corticosterone || Cardenolides || Chenodeoxycholic Acid || Cyclopentanes || Macrocyclic Compounds || 2,6-diisopropylnaphthalene || Cardanolides || Cyproterone || Digitalis Glycosides || LG 100268 || GSK 8470 || Ethers, Cyclic || ciclesonide || pirarubicin || 3-benzylidene camphor || Estriol || Cardiac Glycosides || Promegestone || Trichothecenes || Triamcinolone || Cyclohexanecarboxylic Acids || Fluorenes || acetyl methyl tetramethyl tetralin || sulindac sulfone || Cyclohexenes || Naphthalenes || diisononyl 1,2-cyclohexanedicarboxylic acid || Depsipeptides || Cholestenes || versalide || 5-alpha-Dihydroprogesterone || paricalcitol |
| TSP-1 type 1 repeat | 0.006104 | INHERITED FROM: Benzopyrenes || benzo(e)pyrene || Methylprednisolone |
| Nuclear receptor | 0.006513 | INHERITED FROM: AGN 193109 || Norethindrone Acetate || Toxaphene || Carbaryl || Lactams, Macrocyclic || pyrene || Indans || 2,2-bis(4-glycidyloxyphenyl)propane || Cortodoxone || Cholesterol || Cyclopentane Monoterpenes || Estrone || Pyrethrins || Mifepristone || Abietanes || Retinoids || Bridged Bicyclo Compounds || Equilin || Steroids, Chlorinated || Dehydroepiandrosterone || Valinomycin || Retinaldehyde || Megestrol || Camphor || Phenanthrenes || Budesonide || 1-hydroxypyrene || Oxymetholone || enzacamene || 4-hydroxyretinoic acid || phantolid || Bile Acids and Salts || Pregnanediones || tibolone || Alitretinoin || 1,1-bis(4-hydroxyphenyl)cyclohexane || Pregnadienediols || Medroxyprogesterone || Androstanes || 3-acetyldeoxynivalenol || Steroids, Heterocyclic || Anthracenes || Bridged-Ring Compounds || beta Carotene || Rifamycins || Danazol || tetralin || Epirubicin || Cholanes || cyhalothrin || Fenretinide || Hydroxycholesterols || Ciclopirox || Indenes || Cholic Acids || Cholestanes || Medroxyprogesterone Acetate || Sterols || Simvastatin || 9-cis-retinal || Prednisolone || phenothrin || 4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid || Bexarotene || Polyketides || Permethrin || Fulvestrant || SR 11237 || fenvalerate || Digitoxin || 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid || Cycloparaffins || Betamethasone || Idarubicin || Ketosteroids || Corticosterone || Cardenolides || Chenodeoxycholic Acid || Cyclopentanes || Macrocyclic Compounds || 2,6-diisopropylnaphthalene || Cardanolides || Digitalis Glycosides || LG 100268 || Ethers, Cyclic || ciclesonide || pirarubicin || 3-benzylidene camphor || Estriol || Cardiac Glycosides || Promegestone || Trichothecenes || Triamcinolone || Cyclohexanecarboxylic Acids || Fluorenes || acetyl methyl tetramethyl tetralin || sulindac sulfone || Cyclohexenes || Naphthalenes || diisononyl 1,2-cyclohexanedicarboxylic acid || Cholestenes || versalide || 5-alpha-Dihydroprogesterone || paricalcitol |
| Interleukin 8-like chemokines | 0.00838 | INHERITED FROM: Oxytetracycline || Ursodeoxycholic Acid || Cholesterol || Pregnenes || Mifepristone || Bridged Bicyclo Compounds || butenafine || Steroids, Chlorinated || Proscillaridin || Fludrocortisone || roflumilast N-oxide || Budesonide || enzacamene || Beclomethasone || Norbornanes || pevonedistat || Pregnenediones || Terbinafine || Minocycline || sirtinol || Lanatosides || Cholestenones || beta Carotene || Bicyclic Monoterpenes || 1-nitropyrene || Sterols || Simvastatin || Prednisolone || Dibenzocycloheptenes || meclocycline || 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol || Cyclopropanes || Polyketides || Digitoxigenin || Strophanthins || 3-nitrofluoranthene || Fulvestrant || Camphanes || Digitoxin || Betamethasone || Bufanolides || Antimycin A || primycin || Roflumilast || beta-hydroxy simvastatin acid || Digitalis Glycosides || Benzocycloheptenes || Ergosterol || 3-aminofluoranthene || Withanolides || Phytosterols || Chrysenes || Tetracyclines || Digoxin || Methylprednisolone || BIRB 796 || Trichothecenes || Morphinans || Fluorenes || Cholestenes || coagulin-L || Morphine Derivatives |
| Protein kinases, catalytic subunit | 0.009168 | INHERITED FROM: Ouabain || Macrolides || Lactams, Macrocyclic || ethyl 8-oxo-8H-acenaphtho(1,2-b)pyrrole-9-carboxylate || Lycopene || dioscin || 3-O-caffeoyl-1-methylquinic acid || Diosgenin || NSC 680410 || Bile Acids and Salts || Cyclodextrins || beta-Cyclodextrins || chrysophanic acid || 5H-benzo(4,5)cyclohepta(1,2-b)pyridin-5-one || aucubin || tamibarotene || Cholanes || Indenes || Cholic Acids || Maytansine || Polyketides || Fulvestrant || Cyclodecanes || napabucasin || Camphanes || Spirostans || Benzopyrenes || tanespimycin || Cardanolides || Win 55212-2 || liposomal doxorubicin || 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione || cyanoginosin LR || Benzocycloheptenes || Polycyclic Aromatic Hydrocarbons || Microcystins || Cardiac Glycosides || picropodophyllin || Naphthalenes || beta-ionone || Iridoid Glycosides |
| Bromodomain | 0.01076 | INHERITED FROM: Pregnadienes || deoxynivalenol |
| Tyrosine-dependent oxidoreductases | 0.01749 | INHERITED FROM: 9,10-phenanthrenequinone || Estrone || Dehydroepiandrosterone || Androstenediols || Androstenedione || 1,2-naphthoquinone || bifenthrin || Ketosteroids || Cortisone || Isotretinoin || Androstenediol |
| Laminin G-like module | 0.01767 | INHERITED FROM: Retinoids || Cyclohexanes |
| Mitochondrial carrier | 0.02068 | INHERITED FROM: CD 437 || Sesquiterpenes, Eudesmane || Thapsigargin || dehydroabietylamine || enniatins || Polycyclic Sesquiterpenes || Sesquiterpenes, Guaiane || Cycloheptanes |
| SH2 domain | 0.02173 | INHERITED FROM: naphtho(1,2-b)furan-4,5-dione || benzo(a)pyrene-3,6-quinone || 4-acetylantroquinonol B || benzo(a)pyrene-1,6-quinone || tamibarotene || Cyclohexanones || caryophyllene || Naphthalenes |
| Third domain of FERM | 0.02254 | INHERITED FROM: Doxorubicin || Daunorubicin || Anthracyclines || Benzopyrenes |
| Growth factor receptor domain | 0.02585 | INHERITED FROM: Pregnenediones || Medroxyprogesterone Acetate || Paclitaxel || Tetracycline || Progesterone || 9,10-dihydro-9,10-dihydroxybenzo(a)pyrene || Cyclohexenes |
| Calponin-homology domain, CH-domain | 0.03415 | INHERITED FROM: Polycyclic Aromatic Hydrocarbons |
| ABC transporter ATPase domain-like | 0.03436 | INHERITED FROM: Lactams, Macrocyclic || Cholestadienes || 2-Acetylaminofluorene || Bile Acids and Salts || Pregnenediones || Loratadine || Rifamycins || Cholanes || Cholic Acids || estradiol-17 beta-glucuronide || Dibenzocycloheptenes || Pravastatin || Cholic Acid || Cyclodecanes || Cycloparaffins || calcein AM || Methyltestosterone || Fluoresceins || Taxoids || Benzocycloheptenes || Cyproheptadine || Progesterone || Docetaxel || Rifampin || Spiro Compounds || fluorexon |
| Second domain of FERM | 0.03496 | INHERITED FROM: Pyrenes || Benzopyrenes |
| G proteins | 0.05666 | INHERITED FROM: Lovastatin || 15-acetyldeoxynivalenol || myrtenol |
| Glutathione S-transferase (GST), C-terminal domain | 0.05796 | INHERITED FROM: Okadaic Acid || dibenzo(a,l)pyrene || Tetrapyrroles || Androstenedione || microcystin RR || beta Carotene || apocarotenal || 17-Ketosteroids || Ketosteroids || Bile Pigments || Microcystins || Naphthalenesulfonates || apple polyphenol extract || Spiro Compounds |
| Fibronectin type III | 0.06437 | INHERITED FROM: Pyrenes || benzo(e)pyrene |
| SNARE fusion complex | 0.0728 | INHERITED FROM: Heroin || Morphinans || Morphine Derivatives |
| Myb/SANT domain | 0.08144 | INHERITED FROM: Fulvestrant || Cyproterone |
| Armadillo repeat | 0.08144 | INHERITED FROM: Hydroxycholecalciferols || Dihydroxycholecalciferols || Calcitriol || Cholestanes || Sterols || Cholecalciferol || Secosteroids || Cholestenes |
| First domain of FERM | 0.08144 | INHERITED FROM: Benzopyrenes |
| Motor proteins | 0.08452 | INHERITED FROM: Androstanes || Pyrenes || Benzopyrenes |
| PAPS sulfotransferase | 0.09126 | INHERITED FROM: Estrone || Dehydroepiandrosterone || 1-hydroxypyrene || benzo(a)pyrene-7,8-dione || 2-hydroxyestradiol || Norpregnatrienes || 2-Naphthylamine || 17-Ketosteroids || Ketosteroids || 1-hydroxymethylpyrene || glycidamide |
| Hemopexin-like domain | 0.102 | INHERITED FROM: Ouabain || Mifepristone || pyrazolanthrone || manganese(III)-tetrakis(4-benzoic acid)porphyrin || Chlorogenic Acid || cyclo(Trp-Asp-Pro-Val-Leu) || 1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one || Pregnenediones || Tetrapyrroles || Lovastatin || Anthracenes || Estradiol || Simvastatin || Wortmannin || Paclitaxel || Doxycycline || Cyclodecanes || 3-caffeoyl-4-dihydrocaffeoylquinic acid || Porphyrins || Tetracyclines || Progesterone || Cardiac Glycosides || bufalin || Spiro Compounds |
| Glutathione S-transferase (GST), N-terminal domain | 0.102 | INHERITED FROM: beta Carotene || apocarotenal || Cyclohexanes |
| Matrix metalloproteases, catalytic domain | 0.102 | INHERITED FROM: Ouabain || mibolerone || Mifepristone || pyrazolanthrone || manganese(III)-tetrakis(4-benzoic acid)porphyrin || Chlorogenic Acid || cyclo(Trp-Asp-Pro-Val-Leu) || 1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one || Pregnenediones || Hydroxycholecalciferols || Dihydroxycholecalciferols || Tetrapyrroles || Lovastatin || Anthracenes || Nandrolone || Calcitriol || Estradiol || Sterols || Simvastatin || Wortmannin || Paclitaxel || Doxycycline || Cycloparaffins || 3-caffeoyl-4-dihydrocaffeoylquinic acid || Porphyrins || Tetracyclines || Progesterone || Cardiac Glycosides || bufalin || Spiro Compounds || Cholestenes |
| Integrin A (or I) domain | 0.1173 | INHERITED FROM: Pregnenes || Pregnanes || Pregnenediones || Hydroxycholecalciferols || Dihydroxycholecalciferols || Medroxyprogesterone || Calcitriol || Estradiol || Medroxyprogesterone Acetate || Sterols || Paclitaxel || Cyclodecanes || Cholestenes |
| PDEase | 0.1271 | INHERITED FROM: Cyclopropanes || Benzopyrenes || Cilomilast || Roflumilast || Cyclohexanecarboxylic Acids |
| Frizzled cysteine-rich domain | 0.142 | INHERITED FROM: Mifepristone || Tretinoin || Pregnadienetriols || Dexamethasone || Vitamin A |
| Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain) | 0.142 | INHERITED FROM: Desogestrel |
| UDPGT-like | 0.142 | INHERITED FROM: Naphthols || Estrone || Morphine || 1,2,5,8-tetrahydroxy anthraquinone || 3-hydroxydesloratadine || 2,6-dihydroxyanthraquinone || Phenanthrenes || 1-hydroxypyrene || alizarin || Bile Acids and Salts || dibenzo(a,l)pyrene || ranirestat || 2-hydroxyestradiol || shikonin || Anthracenes || plumbagin || 1,4-dihydroxyanthraquinone || Loratadine || Cholanes || Hydroxyestrones || 1-naphthol || Benz(a)Anthracenes || Indenes || Cholic Acids || Naproxen || Dibenzocycloheptenes || Anthraquinones || Sulindac || Ketosteroids || Naphthaleneacetic Acids || 2-Methoxyestradiol || Pregnenolone Carbonitrile || Methylcholanthrene || Bile Pigments || anthrarobin || Benzocycloheptenes || Cyproheptadine || Androsterone || Pregnenolone || Estriol || Rifampin || Emodin || Morphinans || 4-hydroxyestrone || Cyclohexanecarboxylic Acids || sulindac sulfone || Naphthalenes || alloin || Spiro Compounds || Anthralin || Deoxycholic Acid || Morphine Derivatives |
| SNF-like | 0.1579 | INHERITED FROM: Indans || Cyclohexanones || 2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone || indatraline || Cyclohexylamines |
| MMP N-terminal domain | 0.1579 | INHERITED FROM: Ouabain || mibolerone || Mifepristone || pyrazolanthrone || manganese(III)-tetrakis(4-benzoic acid)porphyrin || Chlorogenic Acid || cyclo(Trp-Asp-Pro-Val-Leu) || 1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one || Pregnenediones || Hydroxycholecalciferols || Dihydroxycholecalciferols || Tetrapyrroles || Lovastatin || Anthracenes || Nandrolone || Calcitriol || Estradiol || Sterols || Simvastatin || Wortmannin || Paclitaxel || Doxycycline || Cyclodecanes || 3-caffeoyl-4-dihydrocaffeoylquinic acid || Cardanolides || Porphyrins || Tetracyclines || Progesterone || Cardiac Glycosides || bufalin || Cyclohexanecarboxylic Acids || Spiro Compounds || Cholestenes |
| Proteasome subunits | 0.1579 | INHERITED FROM: microcystin RR || Microcystins |
| Caspase recruitment domain, CARD | 0.1579 | INHERITED FROM: Macrolides || Pyrethrins || Menthol || beauvericin || Cyclohexanols || pyrazolanthrone || Cyclohexane Monoterpenes || tauroursodeoxycholic acid || diepoxybutane || deoxynivalenol || Epichlorohydrin || Cyclohexanes || Cyclodecanes || Cycloparaffins || Bufanolides || Chenodeoxycholic Acid || Macrocyclic Compounds || Taxoids || cypermethrin || Taurodeoxycholic Acid || Taurocholic Acid || bafilomycin A1 || Taurochenodeoxycholic Acid |
| Leucine zipper domain | 0.165 | INHERITED FROM: Retinoids || Cyclosporins || SR 144528 || Sesquiterpenes, Eudesmane || Bile Acids and Salts || tauroursodeoxycholic acid || 1-Naphthylamine || Pregnenediones || Brefeldin A || Tetrapyrroles || Thapsigargin || Anthracenes || Bridged-Ring Compounds || Cholanes || Estradiol || 1-nitropyrene || Cholic Acids || Hemin || Norpregnatrienes || diphenylcyclopropenone || Sulindac || Camphanes || Macrocyclic Compounds || cyanoginosin LR || Polycyclic Sesquiterpenes || Withanolides || Sesquiterpenes, Guaiane || nodularin || 9,10-dihydro-9,10-dihydroxybenzo(a)pyrene || withaferin A || Trichothecenes || Cycloheptanes || Cyclohexenes || Naphthalenes || Cholestenes || Sertraline |
| VWC domain | 0.1758 | INHERITED FROM: Norsteroids || testosterone enanthate |
| Cyclin | 0.1917 | INHERITED FROM: Ursodeoxycholic Acid || tylophorine || HS 1030 || apicidin || Steroids, Heterocyclic || HS 1200 || seocalcitol || Wortmannin || Paclitaxel || Polyketides || Brassinosteroids || Sulindac || brassinolide || Fulvestrant || Cyclodecanes || 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid || HS 1183 || Cardenolides || AGN 194204 || 2-Methoxyestradiol || Taxoids || LG 100268 || HS-1199 || Spiro Compounds |
| DBL homology domain (DH-domain) | 0.193 | INHERITED FROM: Hydroxycholecalciferols || Dihydroxycholecalciferols || Calcitriol || Cholecalciferol || benzo(e)pyrene |
| Arylsulfatase | 0.1955 | INHERITED FROM: yessotoxin || Oxocins |
| Nucleosome core histones | 0.1969 | INHERITED FROM: Naphthoquinones || Ergocalciferols || MT19c compound |
| Canonical RBD | 0.2024 | INHERITED FROM: 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol || Dihydroxydihydrobenzopyrenes || yessotoxin || 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide || pateamine A || Oxocins |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.2091 | INHERITED FROM: Ouabain || Strophanthins || Cardenolides || Cardiac Glycosides |
| Extended AAA-ATPase domain | 0.231 | INHERITED FROM: 2,3-dimethoxy-1,4-naphthoquinone |
| Penta-EF-hand proteins | 0.2418 | INHERITED FROM: Menthol || Cyclohexanols || Cyclohexane Monoterpenes |
| Clathrin coat assembly domain | 0.2418 | INHERITED FROM: yessotoxin || Oxocins |
| Hypoxia-inducible factor Hif2a, C-terminal domain | 0.2418 | INHERITED FROM: fluoranthene || Okadaic Acid || Rifamycins || Rifampin || Fluorenes |
| Calcium ATPase, transmembrane domain M | 0.2418 | INHERITED FROM: Ouabain || Strophanthins || Cardenolides || Cardanolides || Cardiac Glycosides |
| Calcium ATPase, transduction domain A | 0.2516 | INHERITED FROM: Ouabain || Strophanthins || Cardenolides |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.2628 | INHERITED FROM: Bryostatins |
| Acetylcholinesterase-like | 0.268 | INHERITED FROM: Indans || 6-O-monoacetylmorphine || Cyclopentane Monoterpenes || Pyrethrins || Phenanthrenes || Heroin || Morphinans || Morphine Derivatives |
| GLA-domain | 0.268 | INHERITED FROM: Gestodene || Pregnenediones || Medroxyprogesterone || estradiol, norethindrone drug combination || Nandrolone || norgestimate, ethinyl estradiol drug combination || dienogest || Norsteroids || Medroxyprogesterone Acetate || Norpregnatrienes || Norpregnenes || estradiol valerate-dienogest || ethinyl estradiol-desogestrel combination |
| Serpins | 0.269 | INHERITED FROM: 2,3-dimethoxy-1,4-naphthoquinone || Hydroxycholecalciferols || Dihydroxycholecalciferols || Calcitriol || Norsteroids || Cholic Acids || Norpregnatrienes || Rifampin || ethinyl estradiol-desogestrel combination || Estranes || Cholestenes |
| Tubulin, GTPase domain | 0.2903 | INHERITED FROM: Sesquiterpenes, Eudesmane || 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol || dibenzo(a,l)pyrene || Thapsigargin || Polycyclic Sesquiterpenes || Sesquiterpenes, Guaiane |
| Toll/Interleukin receptor TIR domain | 0.2903 | INHERITED FROM: 9,10-dihydro-2,5-dimethoxyphenanthrene-1,7-diol || Paclitaxel || Cyclodecanes || Ivermectin |
| PDI-like | 0.2976 | INHERITED FROM: Sesquiterpenes, Eudesmane || Thapsigargin || Polycyclic Sesquiterpenes || Sesquiterpenes, Guaiane || Cycloheptanes |
| Caspase catalytic domain | 0.2976 | INHERITED FROM: Macrolides || 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole || Lactams, Macrocyclic || Donepezil || methyl 5-chloro-4,5-didehydrojasmonate || Pyrethrins || Glycodeoxycholic Acid || CD 437 || cinobufotalin || Morphine || Menthol || Cyclohexanols || pyrazolanthrone || manganese(III)-tetrakis(4-benzoic acid)porphyrin || Diosgenin || NSC 680410 || Cyclohexane Monoterpenes || 1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one || Phenanthrenes || Sesquiterpenes, Eudesmane || indioside D || Bile Acids and Salts || apicidin || tauroursodeoxycholic acid || Dactinomycin || 1-Naphthylamine || Sapogenins || Amantadine || Androstadienes || Lovastatin || diepoxybutane || deoxynivalenol || WP 631 || Anthracenes || Bridged-Ring Compounds || Loratadine || Epirubicin || Cholanes || Estradiol || 1,4-anthraquinone || Fenretinide || Oleanolic Acid || Epoxy Compounds || methyl protodioscin || Indenes || Cholic Acids || Wortmannin || dehydroxymethylepoxyquinomicin || Propranolol || Dibenzocycloheptenes || echinocystic acid || Anthraquinones || Polyketides || zinc protoporphyrin || Cyclohexanes || Sulindac || Cyclodecanes || Digitoxin || Cycloparaffins || pregna-4,17-diene-3,16-dione || Spirostans || Bufanolides || Chenodeoxycholic Acid || Glycochenodeoxycholic Acid || 2-Methoxyestradiol || Cyclopentanes || alantolactone || Xanthophylls || cobaltiprotoporphyrin || Cardanolides || Win 55212-2 || Taxoids || Benzocycloheptenes || Polycyclic Sesquiterpenes || cypermethrin || Cyproheptadine || Cyclohexanones || Acitretin || Sesquiterpenes, Guaiane || Taurodeoxycholic Acid || Ethers, Cyclic || Taurocholic Acid || Vitamin K || Adamantane || bafilomycin A1 || Rifampin || Cardiac Glycosides || 2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyc || Glycocholic Acid || Trichothecenes || Cyclohexanecarboxylic Acids || Cycloheptanes || sulindac sulfide || Taurochenodeoxycholic Acid || Naphthalenes || Spiro Compounds || Depsipeptides || Deoxycholic Acid || Morphine Derivatives || Sertraline |
| Calpain large subunit, middle domain (domain III) | 0.2976 | INHERITED FROM: Menthol || Cyclohexane Monoterpenes || Epoxy Compounds || glycidamide |
| FAD/NAD-linked reductases, N-terminal and central domains | 0.2976 | INHERITED FROM: Cyclosporins || juglone || Indenes || Cholic Acids || Sulindac || Peptides, Cyclic |
| Tubulin, C-terminal domain | 0.3142 | INHERITED FROM: Sesquiterpenes, Eudesmane || 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol || dibenzo(a,l)pyrene || Thapsigargin || Polycyclic Sesquiterpenes || Sesquiterpenes, Guaiane |
| Gonadodropin/Follitropin | 0.3643 | INHERITED FROM: Estradiol |
| Rap/Ran-GAP | 0.3643 | INHERITED FROM: Dihydroxydihydrobenzopyrenes |
| Acetyl-CoA synthetase-like | 0.3751 | INHERITED FROM: obeticholic acid || Deoxycholic Acid |
| Meta-cation ATPase, catalytic domain P | 0.3952 | INHERITED FROM: Ouabain || Strophanthins || Cardenolides || Cardanolides || Cardiac Glycosides |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0.4037 | INHERITED FROM: CD 437 || Bridged-Ring Compounds || yessotoxin || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Ethers, Cyclic || Adamantane || Oxocins |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.4037 | INHERITED FROM: Tetrapyrroles || aurin || Thiostrepton || Polyketides || Porphyrins || Ivermectin || Cyclohexanecarboxylic Acids |
| ets domain | 0.4249 | INHERITED FROM: mibolerone || Nandrolone |
| N-acetyl transferase, NAT | 0.4251 | INHERITED FROM: testosterone-3-carboxymethyloxime-bovine serum albumin conjugate |
| Tropomyosin | 0.4251 | INHERITED FROM: Mitoxantrone |
| Transforming growth factor (TGF)-beta | 0.4411 | INHERITED FROM: Octreotide || Pregnenediones || Estradiol || Progesterone || Protoporphyrins || Oxocins || brevetoxin 2 |
| C2 set domains | 0.4453 | INHERITED FROM: Macrolides || Cholesterol || Mifepristone || Retinoids || Phenanthrenes || 24,25-epoxycholesterol || Carotenoids || Indenes || Simvastatin || Norpregnatrienes || Polyketides || Cyclohexanes || Sulindac || Norpregnenes || Cyclohexenes || Hydrocortisone || Deoxycholic Acid |
| Glutathione peroxidase-like | 0.4568 | INHERITED FROM: obeticholic acid || Bile Acids and Salts || Tetrapyrroles || Cholanes || Cholic Acids || Ethers, Cyclic || glycidamide || Deoxycholic Acid |
| Aldo-keto reductases (NADP) | 0.4912 | INHERITED FROM: 9,10-phenanthrenequinone || Pregnanolone || benzo(a)pyrene-3,6-quinone || Estrone || acenaphthene-1-ol || Retinaldehyde || Phenanthrenes || Hydroxysteroids || benzo(a)pyrene-7,8-dione || Bile Acids and Salts || Pregnanediones || dibenzo(a,l)pyrene || Medroxyprogesterone || benzo(a)pyrene-1,6-quinone || tetralol || Steroids, Heterocyclic || 4-hydroxyequilenin-o-quinone || Dydrogesterone || Cholanes || Tetralones || Benz(a)Anthracenes || Indenes || 3-nitrobenzanthrone || Cholic Acids || Medroxyprogesterone Acetate || 9-cis-retinal || 1,2-naphthoquinone || Naproxen || 3-aminobenzanthrone || tetrahydrodeoxycorticosterone || 16-ketoestrone || cyclopentanone || daunorubicinol || Ketosteroids || Corticosterone || Naphthaleneacetic Acids || Acenaphthenes || N-hydroxy-3-aminobenzanthrone || Chrysenes || Ethers, Cyclic || 9,10-dihydro-9,10-dihydroxybenzo(a)pyrene || benzo(a)pyrene 7,8-dihydrodiol || glycidamide || Desoxycorticosterone || Equilenin || Azasteroids || cyclopentanol || 20-alpha-Dihydroprogesterone || Fluorenes || Naphthalenes || Dutasteride || Deoxycholic Acid || 5-alpha-Dihydroprogesterone |
| Cyclophilin (peptidylprolyl isomerase) | 0.4912 | INHERITED FROM: yessotoxin || Oxocins |
| A DNA-binding domain in eukaryotic transcription factors | 0.525 | INHERITED FROM: obeticholic acid || Bile Acids and Salts || 1-Naphthylamine || Tetrapyrroles || deoxynivalenol || Tretinoin || Cholanes || Epoxy Compounds || Cholic Acids || Hemin || Vitamin K 3 || 9,10-dihydro-9,10-dihydroxybenzo(a)pyrene || Vitamin K || Trichothecenes || Vitamin A || Deoxycholic Acid || Sertraline |
| L domain | 0.5432 | INHERITED FROM: Mitoxantrone || Anthracenes || Podophyllotoxin || Epirubicin || Indenes || Paclitaxel || Tetrahydronaphthalenes || Polyketides || Sulindac || Fulvestrant || Cyclopentanes || Etoposide || sulindac sulfide |
| Plakin repeat | 0.5432 | INHERITED FROM: Hydroxycholecalciferols || Dihydroxycholecalciferols || Calcitriol || Sterols || Cholecalciferol || Cholestenes |
| MPP-like | 0.5432 | INHERITED FROM: Isotretinoin |
| Choline/Carnitine O-acyltransferase | 0.5432 | INHERITED FROM: Bile Acids and Salts || Cholanes || Cholic Acids || Deoxycholic Acid |
| Calpain large subunit, catalytic domain (domain II) | 0.5621 | INHERITED FROM: Menthol || Cyclohexane Monoterpenes || Epoxy Compounds || glycidamide |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0.6006 | INHERITED FROM: Phenanthrenes || Tetrapyrroles || Metalloporphyrins || Polyketides || Tacrolimus |
| E2F dimerization segment | 0.6006 | INHERITED FROM: Menthol || Cyclohexane Monoterpenes || Paclitaxel || Cyclodecanes || Taxoids |
| NADPH-cytochrome p450 reductase-like | 0.6006 | INHERITED FROM: Phenanthrenes || Tetrapyrroles || Metalloporphyrins || Polyketides || Tacrolimus |
| MHC antigen-recognition domain | 0.6137 | INHERITED FROM: Minocycline || tamibarotene || Erythromycin || Tetrahydronaphthalenes || Tetracyclines || Naphthalenes |
| Dual specificity phosphatase-like | 0.6294 | INHERITED FROM: 1-Naphthylamine || Sertraline |
| Cold shock DNA-binding domain-like | 0.6377 | INHERITED FROM: beauvericin || Depsipeptides |
| C1 set domains (antibody constant domain-like) | 0.6377 | INHERITED FROM: Minocycline || tamibarotene || Erythromycin || Tetrahydronaphthalenes || Tetracyclines || Naphthalenes |
| Group II chaperonin (CCT, TRIC), apical domain | 0.6822 | INHERITED FROM: CD 437 || Okadaic Acid || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Adamantane |
| Fibronectin type II module | 0.6822 | INHERITED FROM: Ouabain || Steroids, Chlorinated || Beclomethasone || Sapogenins || Tetrapyrroles || Medroxyprogesterone || Oleanolic Acid || Medroxyprogesterone Acetate || Propranolol || Strophanthins || Cardenolides || Cardanolides || Porphyrins || Cardiac Glycosides || Spiro Compounds |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0.7253 | INHERITED FROM: CD 437 || Okadaic Acid || Bridged-Ring Compounds || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Adamantane |
| Cell cycle transcription factor e2f-dp | 0.7253 | INHERITED FROM: Testosterone || Menthol || Cyclohexanols || Cyclohexane Monoterpenes || Androstenols || Paclitaxel || Androstenes |
| CCCH zinc finger | 0.7623 | INHERITED FROM: 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol |
| Elongation factors | 0.7624 | INHERITED FROM: Metribolone |
| Pentraxin (pentaxin) | 0.7689 | INHERITED FROM: Medroxyprogesterone || Medroxyprogesterone Acetate |
| Nucleoside diphosphate kinase, NDK | 0.7689 | INHERITED FROM: Menthol || Cyclohexane Monoterpenes |
| Interleukin-1 (IL-1) | 0.7689 | INHERITED FROM: Cholesterol || pyrazolanthrone || Lovastatin || Metalloporphyrins || 1-nitropyrene || Simvastatin || Polyketides || Methylcholanthrene || Oxysterols || Hydrocortisone || paricalcitol |
| Voltage-gated potassium channels | 0.7792 | INHERITED FROM: Propranolol |
| Nicotinic receptor ligand binding domain-like | 0.7849 | INHERITED FROM: Pregnanolone || carvone || tetramethylenedisulfotetramine || Camphor || menthone || 13-desmethylspirolide C || Bridged-Ring Compounds || 13,19-didesmethyl spirolide C || N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline || Rocuronium || Picrotoxin || isoborneol || Pancuronium || Vecuronium Bromide || beta-thujone |
| Small Kunitz-type inhibitors & BPTI-like toxins | 0.7945 | INHERITED FROM: Paclitaxel || Cyclodecanes |
| I set domains | 0.8021 | INHERITED FROM: 5H-benzo(4,5)cyclohepta(1,2-b)pyridin-5-one || Benzocycloheptenes |
| Ovomucoid domain III-like | 0.8067 | INHERITED FROM: estrone sulfate |
| Translational machinery components | 0.8123 | INHERITED FROM: CD 437 || Metribolone |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.889 | INHERITED FROM: Pregnanolone || carvone || tetramethylenedisulfotetramine || Camphor || menthone || 13-desmethylspirolide C || Bridged-Ring Compounds || 13,19-didesmethyl spirolide C || N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline || Rocuronium || Picrotoxin || isoborneol || Pancuronium || Vecuronium Bromide || beta-thujone |
| Cytochrome p450 reductase N-terminal domain-like | 0.898 | INHERITED FROM: Phenanthrenes || Metalloporphyrins || Polyketides || Porphyrins || Tacrolimus |
| Ran-binding domain | 0.9202 | INHERITED FROM: Methylcholanthrene |
| S100 proteins | 0.9398 | INHERITED FROM: Hydroxycholecalciferols || Alitretinoin || Dihydroxycholecalciferols || 4-oxoretinoic acid || Calcitriol || Sterols || Cholecalciferol || Cholestenes |
| Retinol binding protein-like | 0.9398 | INHERITED FROM: 1-anilino-8-naphthalenesulfonate || 11-(dansylamino)undecanoic acid || Dansyl Compounds || Naphthalenesulfonates || Anilino Naphthalenesulfonates |
| Actin/HSP70 | 0.9462 | INHERITED FROM: aurin || Metalloporphyrins || Thiostrepton || Hemin || Ivermectin || bufalin || Cyclohexanecarboxylic Acids |
| Fibroblast growth factors (FGF) | 0.9562 | INHERITED FROM: Suramin || Naphthalenesulfonates |
| Insulin-like | 0.9723 | INHERITED FROM: Testosterone || Androstenols || Androstanes || Norgestrel || Norsteroids || Wortmannin || Androstenes || Hydrocortisone |
| TNF-like | 0.9736 | INHERITED FROM: Menthol || Cyclohexanols || Plicamycin || Cyclohexane Monoterpenes || Lovastatin || Medroxyprogesterone Acetate || Hydroxyprogesterones || aloe emodin || brevetoxin 2 |
| Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain | 0.9753 | INHERITED FROM: Isotretinoin |
| Fibrinogen C-terminal domain-like | 0.9813 | INHERITED FROM: Gestodene || Norethindrone || Desogestrel || Nandrolone || dienogest || azaspiracid || norgestimate || estradiol valerate-dienogest || ethinyl estradiol-desogestrel combination |
| Chaperone J-domain | 0.992 | INHERITED FROM: Carbaryl || motexafin gadolinium |
| Cadherin | 0.9942 | INHERITED FROM: jasplakinolide |
| HLH, helix-loop-helix DNA-binding domain | 1 | INHERITED FROM: testosterone-3-carboxymethyloxime-bovine serum albumin conjugate || eldecalcitol || dihydroxy-vitamin D3 || azaspiracid || Rifampin || Dihydrotestosterone |
| Galectin (animal S-lectin) | 1 | INHERITED FROM: Benz(a)Anthracenes |
| Rhodopsin-like | 1 | INHERITED FROM: 2-(beta-(3-iodo-4-hydroxyphenyl)ethylaminomethyl)tetralone || 8-Hydroxy-2-(di-n-propylamino)tetralin || Sapogenins || Oleanolic Acid || Rocuronium || methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate || Spiperone || oleandrin || Pancuronium |
| Prefoldin | 1 | INHERITED FROM: Alitretinoin || 4-oxoretinoic acid || sulindac sulfide |
| Interferons/interleukin-10 (IL-10) | 1 | INHERITED FROM: beta Carotene || apocarotenal || Hydrocortisone |
| Homeodomain | 1 | INHERITED FROM: beta Carotene || apocarotenal |
| Long-chain cytokines | 1 | INHERITED FROM: Pregnenes || Pregnenediones || deoxynivalenol || Anthracenes || Dibenzocycloheptenes || 17-Ketosteroids || Ketosteroids || Methylcholanthrene || Benzocycloheptenes || Progesterone || Trichothecenes || Spiro Compounds |
| Eukaryotic proteases | 1 | INHERITED FROM: NuvaRing || Gestodene || Norethindrone || Medroxyprogesterone || estradiol, norethindrone drug combination || Nandrolone || Medroxyprogesterone Acetate || norgestimate || Azasteroids || estradiol valerate-dienogest || ethinyl estradiol-desogestrel combination || Dutasteride |
| Intermediate filament protein, coiled coil region | 1 | INHERITED FROM: Alitretinoin || 4-oxoretinoic acid || beta Carotene || calcipotriene || 4-oxoretinol || ethyl-p-((E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-1-propenyl)benzoic acid || Microcystins || Isotretinoin |
| SCOP term |
FDR (all) |
Annotation (direct or inherited) |
| beta-CASP RNA-metabolising hydrolases | 0 | Direct |
| DNase I-like | 0 | Direct |
| JAB1/MPN domain | 0 | Direct |
| Protein-L-isoaspartyl O-methyltransferase | 0 | Direct |
| Co-chaperone p23-like | 0 | Direct |
| RWD domain | 0 | Direct |
| Kinase associated domain 1, KA1 | 0 | Direct |
| 4HBT-like | 0 | Direct |
| Netrin-like domain (NTR/C345C module) | 0 | Direct |
| Stathmin | 0 | Direct |
| Autophagin-like | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| Diap1 N-terninal region-like | 0 | Direct |
| Pentapeptide repeats | 0 | Direct |
| Connexin43 | 0 | Direct |
| Microbial and mitochondrial ADK, insert "zinc finger" domain | 0 | Direct |
| Other IPT/TIG domains | 0 | Direct |
| Sir2 family of transcriptional regulators | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | Direct |
| C5 cytosine-specific DNA methylase, DCM | 0 | Direct |
| Ribonuclease PH domain 1-like | 0 | Direct |
| Laminin-type module | 0 | Direct |
| Formate/glycerate dehydrogenases, substrate-binding domain | 0 | Direct |
| PreBEACH PH-like domain | 0 | Direct |
| p53 tetramerization domain | 0 | Direct |
| Proprotein convertase P-domain | 0 | Direct |
| Release factor | 0 | Direct |
| Phosphoribosylpyrophosphate synthetase-like | 0 | Direct |
| Oxysterol-binding protein | 0 | Direct |
| VPS9 domain | 0 | Direct |
| Amine oxidase N-terminal region | 0 | Direct |
| TRASH domain | 0 | Direct |
| HAT/Suf repeat | 0 | Direct |
| FAD-dependent thiol oxidase | 0 | Direct |
| Amidase signature (AS) enzymes | 0 | Direct |
| Multidomain cupredoxins | 0 | Direct |
| Putative glucosidase YicI, domain 3 | 0 | Direct |
| BolA-like | 0 | Direct |
| Alcohol dehydrogenase-like, N-terminal domain | 0 | Direct |
| Proton glutamate symport protein | 0 | Direct |
| Alkaline phosphatase | 0 | Direct |
| SpoU-like RNA 2'-O ribose methyltransferase | 0 | Direct |
| Ribosomal protein L1 | 0 | Direct |
| eIF5a N-terminal domain-like | 0 | Direct |
| A20-like zinc finger | 0 | Direct |
| Plakophilin 1 helical region | 0 | Direct |
| Cation efflux protein transmembrane domain-like | 0 | Direct |
| Domain of poly(ADP-ribose) polymerase | 0 | Direct |
| Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains | 0 | Direct |
| Class I aldolase | 0 | Direct |
| IP3 receptor type 1 binding core, domain 2 | 0 | Direct |
| FKBP immunophilin/proline isomerase | 0 | Direct |
| 2'-5'-oligoadenylate synthetase 1, OAS1, second domain | 0 | Direct |
| AXH domain | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| HEAT repeat | 0 | Direct |
| Neurolysin-like | 0 | Direct |
| BEACH domain | 0 | Direct |
| Eps15 homology domain (EH domain) | 0 | Direct |
| Serine carboxypeptidase-like | 0 | Direct |
| ALDH-like | 0 | Direct |
| Mannose 6-phosphate receptor domain | 0 | Direct |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | Direct |
| IF2B-like | 0 | Direct |
| FF domain | 0 | Direct |
| RNB domain-like | 0 | Direct |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | Direct |
| Renal dipeptidase | 0 | Direct |
| 2Fe-2S ferredoxin domains from multidomain proteins | 0 | Direct |
| LON domain-like | 0 | Direct |
| APC10-like | 0 | Direct |
| Phenylalanine metabolism regulatory domain | 0 | Direct |
| Bacterial PLC | 0 | Direct |
| Cytochrome b5 | 0 | Direct |
| Inositol monophosphatase/fructose-1,6-bisphosphatase-like | 0 | Direct |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
| Chromo barrel domain | 0 | Direct |
| Inosine monophosphate dehydrogenase (IMPDH) | 0 | Direct |
| Assembly domain of cartilage oligomeric matrix protein | 0 | Direct |
| MOSC N-terminal domain-like | 0 | Direct |
| Complement components | 0 | Direct |
| DNA ligase | 0 | Direct |
| Phosphoglucomutase, C-terminal domain | 0 | Direct |
| Ribonuclease H | 0 | Direct |
| YicI catalytic domain-like | 0 | Direct |
| BC C-terminal domain-like | 0 | Direct |
| Subtilases | 0 | Direct |
| Methyl-CpG-binding domain, MBD | 0 | Direct |
| DEATH effector domain, DED | 0 | Direct |
| PWI domain | 0 | Direct |
| DNA gyrase/MutL, N-terminal domain | 0 | Direct |
| D-aminoacid oxidase-like | 0 | Direct |
| Integrin domains | 0 | Direct |
| Ribosomal protein S10 | 0 | Direct |
| Hermes transposase-like | 0 | Direct |
| Leukotriene A4 hydrolase catalytic domain | 0 | Direct |
| MAPEG domain | 0 | Direct |
| S-adenosylhomocystein hydrolase | 0 | Direct |
| Lesion bypass DNA polymerase (Y-family), catalytic domain | 0 | Direct |
| Histone deacetylase, HDAC | 0 | Direct |
| Phosphofructokinase | 0 | Direct |
| alpha-catenin/vinculin | 0 | Direct |
| MAST3 pre-PK domain-like | 0 | Direct |
| WW domain | 0 | Direct |
| beta 1,4 galactosyltransferase (b4GalT1) | 0 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
| NagB-like | 0 | Direct |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain | 0 | Direct |
| Arginase-like amidino hydrolases | 0 | Direct |
| PAS domain of steroid receptor coactivator 1A, NCo-A1 | 0 | Direct |
| Cyclin A/CDK2-associated p19, Skp2 | 0 | Direct |
| Oligoxyloglucan reducing end-specific cellobiohydrolase | 0 | Direct |
| Extracellular domain of cell surface receptors | 0 | Direct |
| Noncollagenous (NC1) domain of collagen IV | 0 | Direct |
| FCH domain | 0 | Direct |
| SWIB/MDM2 domain | 0 | Direct |
| DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
| Peptidylarginine deiminase Pad4, catalytic C-terminal domain | 0 | Direct |
| Peptidylglycine alpha-hydroxylating monooxygenase, PHM | 0 | Direct |
| DLC | 0 | Direct |
| Mitochondrial cytochrome c oxidase subunit VIIa | 0 | Direct |
| P-domain of calnexin/calreticulin | 0 | Direct |
| Prokaryotic proteases | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Peptidylarginine deiminase Pad4, middle domain | 0 | Direct |
| 2'-5'-oligoadenylate synthetase 1, OAS1, N-terminal domain | 0 | Direct |
| GTF2I-like repeat | 0 | Direct |
| DNA polymerase III clamp loader subunits, C-terminal domain | 0 | Direct |
| STAT | 0 | Direct |
| TatD Mg-dependent DNase-like | 0 | Direct |
| FucT-like | 0 | Direct |
| Enabled/VASP homology 1 domain (EVH1 domain) | 0 | Direct |
| Metallothionein | 0 | Direct |
| acyl-CoA oxidase C-terminal domains | 0 | Direct |
| DEK C-terminal domain | 0 | Direct |
| Fascin | 0 | Direct |
| Platelet-derived growth factor-like | 0 | Direct |
| Pseudouridine synthase RsuA/RluD | 0 | Direct |
| Threonyl-tRNA synthetase (ThrRS), second 'additional' domain | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| a tRNA synthase domain | 0 | Direct |
| Interferon regulatory factor 3 (IRF3), transactivation domain | 0 | Direct |
| Troponin T | 0 | Direct |
| Fibrinogen coiled-coil and central regions | 0 | Direct |
| Selenoprotein W-related | 0 | Direct |
| DEATH domain, DD | 0 | Direct |
| PUG domain | 0 | Direct |
| Ferredoxin reductase FAD-binding domain-like | 0 | Direct |
| FolH catalytic domain-like | 0 | Direct |
| Tetrahydrofolate dehydrogenase/cyclohydrolase | 0 | Direct |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | Direct |
| NOL1/NOP2/sun | 0 | Direct |
| Alpha-adaptin ear subdomain-like | 0 | Direct |
| Anaphylotoxins (complement system) | 0 | Direct |
| Proteasome activator | 0 | Direct |
| Phosphatidylethanolamine binding protein | 0 | Direct |
| SelR domain | 0 | Direct |
| Interferon regulatory factor | 0 | Direct |
| Prohormone convertase 1 pro-domain | 0 | Direct |
| Flavin-binding PAS domain | 0 | Direct |
| Trunk domain of Sec23/24 | 0 | Direct |
| Ribosomal proteins L24p and L21e | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| BTG domain-like | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| Transcription factor IIA (TFIIA), beta-barrel domain | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, C-terminal domain | 0 | Direct |
| Hect, E3 ligase catalytic domain | 0 | Direct |
| Thyroglobulin type-1 domain | 0 | Direct |
| Oncogene products | 0 | Direct |
| EB1 dimerisation domain-like | 0 | Direct |
| PAZ domain | 0 | Direct |
| ATP-dependent DNA ligase catalytic domain | 0 | Direct |
| Small-conductance potassium channel | 0 | Direct |
| CCHHC domain | 0 | Direct |
| Pointed domain | 0 | Direct |
| PABC (PABP) domain | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| alpha-mannosidase | 0 | Direct |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | Direct |
| Starch-binding domain | 0 | Direct |
| Adenain-like | 0 | Direct |
| DUSP, domain in ubiquitin-specific proteases | 0 | Direct |
| Integrin beta tail domain | 0 | Direct |
| Leukotriene A4 hydrolase C-terminal domain | 0 | Direct |
| Ribonuclease PH domain 2-like | 0 | Direct |
| Neutral endopeptidase (neprilysin) | 0 | Direct |
| RNA editing terminal uridyl transferase 2, RET2, domain 2 | 0 | Direct |
| Transcription factor STAT-4 N-domain | 0 | Direct |
| beta-sandwich domain of Sec23/24 | 0 | Direct |
| Bcl-2 inhibitors of programmed cell death | 0 | Direct |
| BC ATP-binding domain-like | 0 | Direct |
| LysM domain | 0 | Direct |
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain | 0 | Direct |
| Choline kinase | 0 | Direct |
| SPOC domain | 0 | Direct |
| p53 DNA-binding domain-like | 0 | Direct |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0 | Direct |
| Occludin/ELL domain | 0 | Direct |
| RNA-polymerase beta | 0 | Direct |
| Clathrin heavy-chain linker domain | 0 | Direct |
| Apolipoprotein A-I | 0 | Direct |
| (Glycosyl)asparaginase | 0 | Direct |
| Chicken cartilage matrix protein | 0 | Direct |
| Cysteine rich domain | 0 | Direct |
| Guanido kinase N-terminal domain | 0 | Direct |
| TAFH domain-like | 0 | Direct |
| Transferrin | 0 | Direct |
| IMD domain | 0 | Direct |
| MIF4G domain-like | 0 | Direct |
| CAT-like | 0 | Direct |
| L27 domain | 0 | Direct |
| La domain | 0 | Direct |
| Arrestin/Vps26-like | 0 | Direct |
| Sedlin (SEDL) | 0 | Direct |
| AAT-like | 0 | Direct |
| DNA/RNA non-specific endonuclease | 0 | Direct |
| Short-chain cytokines | 0 | Direct |
| P4 origin-binding domain-like | 0 | Direct |
| Troponin I | 0 | Direct |
| YWTD domain | 0 | Direct |
| HIT (HINT, histidine triad) family of protein kinase-interacting proteins | 0 | Direct |
| Sema domain | 0 | Direct |
| NagD-like | 0 | Direct |
| Adenylyltransferase | 0 | Direct |
| Mib/herc2 domain | 0 | Direct |
| Osteonectin | 0 | Direct |
| Phoshatidylinositol transfer protein, PITP | 0 | Direct |
| Delta-sleep-inducing peptide immunoreactive peptide | 0 | Direct |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | Direct |
| AraD-like aldolase/epimerase | 0 | Direct |
| Guanido kinase catalytic domain | 0 | Direct |
| BRK domain-like | 0 | Direct |
| F1F0 ATP synthase subunit C | 0 | Direct |
| Hypoxia-inducible factor HIF ihhibitor (FIH1) | 0 | Direct |
| LanC-like | 0 | Direct |
| Gelsolin-like | 0 | Direct |
| Transcription factor IIA (TFIIA), alpha-helical domain | 0 | Direct |
| HtrA-like serine proteases | 0 | Direct |
| Cofactor-dependent phosphoglycerate mutase | 0 | Direct |
| Anticodon-binding domain | 0 | Direct |
| Diacylglycerol kinase-like | 0 | Direct |
| GAT domain | 0 | Direct |
| Eukaryotic ODC-like | 0 | Direct |
| CUE domain | 0 | Direct |
| RIKEN cDNA 2310057j16 protein (KIAA1543) | 0 | Direct |
| B56-like | 0 | Direct |
| Homocysteine S-methyltransferase | 0 | Direct |
| Cystathionine synthase-like | 0 | Direct |
| MSP-like | 0 | Direct |
| Class I glutamine amidotransferases (GAT) | 0 | Direct |
| Notch domain | 0 | Direct |
| Glycolipid transfer protein, GLTP | 0 | Direct |
| Clathrin adaptor core protein | 0 | Direct |
| CPH domain | 0 | Direct |
| Integrin alpha N-terminal domain | 0 | Direct |
| PIWI domain | 0 | Direct |
| ABC transporter transmembrane region | 0 | Direct |
| LCCL domain | 0 | Direct |
| YicI N-terminal domain-like | 0 | Direct |
| Protein prenyltransferases | 0 | Direct |
| COMT-like | 0 | Direct |
| Retinoblastoma tumor suppressor domains | 0 | Direct |
| Serum paraoxonase/arylesterase 1, PON1 | 0 | Direct |
| Transferrin receptor-like dimerisation domain | 0 | Direct |
| PurM C-terminal domain-like | 0 | Direct |
| Soluble quinoprotein glucose dehydrogenase | 0 | Direct |
| NLI interacting factor-like phosphatase | 0 | Direct |
| Alcohol dehydrogenase-like, C-terminal domain | 0 | Direct |
| Serum albumin-like | 0 | Direct |
| Pumilio repeat | 0 | Direct |
| GDI-like N domain | 0 | Direct |
| VHP, Villin headpiece domain | 0 | Direct |
| Ubiquitin activating enzymes (UBA) | 0 | Direct |
| HSP40/DnaJ peptide-binding domain | 0 | Direct |
| Kringle modules | 0 | Direct |
| Biotin dependent carboxylase carboxyltransferase domain | 0 | Direct |
| Rel/Dorsal transcription factors, DNA-binding domain | 0 | Direct |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0 | Direct |
| Animal lipoxigenases | 0 | Direct |
| Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain | 0 | Direct |
| Phosphoribulokinase/pantothenate kinase | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Class I alpha-1;2-mannosidase, catalytic domain | 0 | Direct |
| VHS domain | 0 | Direct |
| GABARAP-like | 0 | Direct |
| Glycerol-3-phosphate transporter | 0 | Direct |
| 5' to 3' exonuclease catalytic domain | 0 | Direct |
| Oligosaccharide phosphorylase | 0 | Direct |
| Arylamine N-methyltransferase | 0 | Direct |
| Alanine racemase-like, N-terminal domain | 0 | Direct |
| PurM N-terminal domain-like | 0 | Direct |
| alpha-mannosidase, C-terminal domain | 0 | Direct |
| Poly(ADP-ribose) polymerase, C-terminal domain | 0 | Direct |
| Peptidylarginine deiminase Pad4, N-terminal domain | 0 | Direct |
| L-aminoacid/polyamine oxidase | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| ECR1 N-terminal domain-like | 0 | Direct |
| Hexokinase | 0 | Direct |
| DNA polymerase beta-like | 0 | Direct |
| MATH domain | 0 | Direct |
| FMN-linked oxidoreductases | 0 | Direct |
| Bacterial exopeptidase dimerisation domain | 0 | Direct |
| Macro domain | 0 | Direct |
| Histone lysine methyltransferases | 0 | Direct |
| Anticodon-binding domain of Class II aaRS | 0 | Direct |
| Zf-UBP | 0 | Direct |
| Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A | 0 | Direct |
| Fumble-like | 0 | Direct |
| Pseudouridine synthase II TruB | 0 | Direct |
| Isoprenyl diphosphate synthases | 0 | Direct |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
| 1,3-glucuronyltransferase | 0 | Direct |
| Family 1 of glycosyl hydrolase | 0 | Direct |
| RPR domain (SMART 00582 ) | 0 | Direct |
| Branched-chain alpha-keto acid dehydrogenase Pyr module | 0 | Direct |
| Calnexin/calreticulin | 0 | Direct |
| USP8 N-terminal domain-like | 0 | Direct |
| Bacterial dinuclear zinc exopeptidases | 0 | Direct |
| PNP-oxidase like | 0 | Direct |
| GHMP Kinase, N-terminal domain | 0 | Direct |
| Formate/glycerate dehydrogenases, NAD-domain | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| Aminoacid dehydrogenase-like, C-terminal domain | 0 | Direct |
| Ccg1/TafII250-interacting factor B (Cib) | 0 | Direct |
| XPF/Rad1/Mus81 nuclease | 0 | Direct |
| PCI domain (PINT motif) | 0 | Direct |
| Cytidylyltransferase | 0 | Direct |
| N-terminal domain of cbl (N-cbl) | 0 | Direct |
| Phosphate binding protein-like | 0 | Direct |
| Reductases | 0 | Direct |
| N-type ATP pyrophosphatases | 0 | Direct |
| Glucose 6-phosphate dehydrogenase-like | 0 | Direct |
| L-aspartase/fumarase | 0 | Direct |
| beta-glycanases | 0 | Direct |
| Variant SAM domain | 0 | Direct |
| Hsp90 middle domain | 0 | Direct |
| FAD-linked reductases, N-terminal domain | 0 | Direct |
| TB module/8-cys domain | 0 | Direct |
| acyl-CoA oxidase N-terminal domains | 0 | Direct |
| Phosphoribosyltransferases (PRTases) | 0 | Direct |
| Nucleoplasmin-like core domain | 0 | Direct |
| Purine and uridine phosphorylases | 0 | Direct |
| Pseudouridine synthase I TruA | 0 | Direct |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
| Nop domain | 0 | Direct |
| ARID domain | 0 | Direct |
| Sec63 C-terminal domain-like | 0 | Direct |
| PB1 domain | 0 | Direct |
| Biotinyl/lipoyl-carrier proteins and domains | 0 | Direct |
| BSD domain | 0 | Direct |
| Steroid-binding domain | 0 | Direct |
| WGR domain | 0 | Direct |
| LeuD-like | 0 | Direct |
| Alpha-macroglobulin receptor domain | 0 | Direct |
| SWIRM domain | 0 | Direct |
| ValRS/IleRS/LeuRS editing domain | 0 | Direct |
| I/LWEQ domain | 0 | Direct |
| UBX domain | 0 | Direct |
| alpha-mannosidase, domain 2 | 0 | Direct |
| Plexin repeat | 0 | Direct |
| Thiolase-related | 0 | Direct |
| Clc chloride channel | 0 | Direct |
| Myeloperoxidase-like | 0 | Direct |
| Arfaptin, Rac-binding fragment | 0 | Direct |
| Domain G2 of nidogen-1 | 0 | Direct |
| Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
| Amine oxidase catalytic domain | 0 | Direct |
| Aconitase iron-sulfur domain | 0 | Direct |
| Medium chain acyl-CoA dehydrogenase-like, C-terminal domain | 0 | Direct |
| SAND domain | 0 | Direct |
| Papain-like | 0 | Direct |
| Carboxypeptidase regulatory domain | 0 | Direct |
| Ferredoxin domains from multidomain proteins | 0 | Direct |
| TSP type-3 repeat | 0 | Direct |
| Formin homology 2 domain (FH2 domain) | 0 | Direct |
| Tissue inhibitor of metalloproteinases, TIMP | 0 | Direct |
| Integrin beta EGF-like domains | 0 | Direct |
| Ribosomal protein L18 and S11 | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| BC N-terminal domain-like | 0 | Direct |
| DNA polymerase I | 0 | Direct |
| Ras GEF | 0 | Direct |
| SH3BGR (SH3-binding, glutamic acid-rich protein-like) | 0 | Direct |
| Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain | 0 | Direct |
| Clathrin adaptor appendage, alpha and beta chain-specific domain | 0 | Direct |
| Inositol polyphosphate kinase (IPK) | 0 | Direct |
| gamma-adaptin C-terminal appendage domain-like | 0 | Direct |
| Ribosomal protein S18 | 0 | Direct |
| Astacin | 0 | Direct |
| Malic enzyme N-domain | 0 | Direct |
| Exostosin | 0 | Direct |
| Protein prenylyltransferase | 0 | Direct |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | Direct |
| Histidine acid phosphatase | 0 | Direct |
| A heparin-binding domain | 0 | Direct |
| Ubiquitin carboxyl-terminal hydrolase UCH-L | 0 | Direct |
| Filamin repeat (rod domain) | 0 | Direct |
| Variant RING domain | 0 | Direct |
| Succinyl-CoA synthetase domains | 0 | Direct |
| HR1 repeat | 0 | Direct |
| SMAD domain | 0 | Direct |
| RNA methyltransferase FtsJ | 0 | Direct |
| HD domain | 0 | Direct |
| GYF domain | 0 | Direct |
| MIT domain | 0 | Direct |
| Scavenger receptor cysteine-rich (SRCR) domain | 0 | Direct |
| STAT DNA-binding domain | 0 | Direct |
| Eferin C-derminal domain-like | 0 | Direct |
| C-terminal domain of PLC-beta | 0 | Direct |
| DNA ligase/mRNA capping enzyme postcatalytic domain | 0 | Direct |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | Direct |
| Glycerophosphoryl diester phosphodiesterase | 0 | Direct |
| Class II glutamine amidotransferases | 0 | Direct |
| Sterol carrier protein, SCP | 0 | Direct |
| Glyoxalase II (hydroxyacylglutathione hydrolase) | 0 | Direct |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0 | Direct |
| UDP-glucose pyrophosphorylase | 0 | Direct |
| DNA polymerase beta, N-terminal domain-like | 0 | Direct |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
| MIR domain | 0 | Direct |
| RuBisCo LSMT catalytic domain | 0 | Direct |
| BAG domain | 0 | Direct |
| DNA gyrase/MutL, second domain | 0 | Direct |
| MBT repeat | 0 | Direct |
| TNF receptor-like | 0 | Direct |
| CAD domain | 0 | Direct |
| C-terminal domain of adenylylcyclase associated protein | 0 | Direct |
| RGC domain | 0 | Direct |
| Formyltransferase | 0 | Direct |
| Phosphoglucomutase, first 3 domains | 0 | Direct |
| Leukotriene A4 hydrolase N-terminal domain | 0 | Direct |
| RBP11/RpoL | 0 | Direct |
| HCDH C-domain-like | 0 | Direct |
| Cell cycle control phosphatase, catalytic domain | 0 | Direct |
| R3H domain | 0 | Direct |
| Carbamilase | 0 | Direct |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
| PAH2 domain | 0 | Direct |
| Sec7 domain | 0 | Direct |
| Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain | 0 | Direct |
| Aminomethyltransferase beta-barrel domain | 0 | Direct |
| DNA replication initiator (cdc21/cdc54) N-terminal domain | 0 | Direct |
| AN1-like Zinc finger | 0 | Direct |
| Thrombospondin C-terminal domain | 0 | Direct |
| SH3-domain | 0.000007989 | Direct |
| Tandem AAA-ATPase domain | 0.0009584 | Direct |
| EGF-type module | 0.00151 | Inherited |
| Cytochrome P450 | 0.001572 | Inherited |
| Synaptotagmin-like (S variant) | 0.003898 | Inherited |
| BCR-homology GTPase activation domain (BH-domain) | 0.004317 | Inherited |
| Pleckstrin-homology domain (PH domain) | 0.004767 | Inherited |
| PHD domain | 0.004844 | Inherited |
| Nuclear receptor ligand-binding domain | 0.005044 | Inherited |
| TSP-1 type 1 repeat | 0.006104 | Inherited |
| Nuclear receptor | 0.006513 | Inherited |
| Interleukin 8-like chemokines | 0.00838 | Inherited |
| Protein kinases, catalytic subunit | 0.009168 | Inherited |
| Bromodomain | 0.01076 | Inherited |
| Tyrosine-dependent oxidoreductases | 0.01749 | Inherited |
| Laminin G-like module | 0.01767 | Inherited |
| Mitochondrial carrier | 0.02068 | Inherited |
| SH2 domain | 0.02173 | Inherited |
| Third domain of FERM | 0.02254 | Inherited |
| Growth factor receptor domain | 0.02585 | Inherited |
| Calponin-homology domain, CH-domain | 0.03415 | Inherited |
| ABC transporter ATPase domain-like | 0.03436 | Inherited |
| Second domain of FERM | 0.03496 | Inherited |
| G proteins | 0.05666 | Inherited |
| Glutathione S-transferase (GST), C-terminal domain | 0.05796 | Inherited |
| Fibronectin type III | 0.06437 | Inherited |
| SNARE fusion complex | 0.0728 | Inherited |
| Myb/SANT domain | 0.08144 | Inherited |
| Armadillo repeat | 0.08144 | Inherited |
| First domain of FERM | 0.08144 | Inherited |
| Motor proteins | 0.08452 | Inherited |
| PAPS sulfotransferase | 0.09126 | Inherited |
| Hemopexin-like domain | 0.102 | Inherited |
| Glutathione S-transferase (GST), N-terminal domain | 0.102 | Inherited |
| Matrix metalloproteases, catalytic domain | 0.102 | Inherited |
| Integrin A (or I) domain | 0.1173 | Inherited |
| PDEase | 0.1271 | Inherited |
| Frizzled cysteine-rich domain | 0.142 | Inherited |
| Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain) | 0.142 | Inherited |
| UDPGT-like | 0.142 | Inherited |
| SNF-like | 0.1579 | Inherited |
| MMP N-terminal domain | 0.1579 | Inherited |
| Proteasome subunits | 0.1579 | Inherited |
| Caspase recruitment domain, CARD | 0.1579 | Inherited |
| Leucine zipper domain | 0.165 | Inherited |
| VWC domain | 0.1758 | Inherited |
| Cyclin | 0.1917 | Inherited |
| DBL homology domain (DH-domain) | 0.193 | Inherited |
| Arylsulfatase | 0.1955 | Inherited |
| Nucleosome core histones | 0.1969 | Inherited |
| Canonical RBD | 0.2024 | Inherited |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.2091 | Inherited |
| Extended AAA-ATPase domain | 0.231 | Inherited |
| Penta-EF-hand proteins | 0.2418 | Inherited |
| Clathrin coat assembly domain | 0.2418 | Inherited |
| Hypoxia-inducible factor Hif2a, C-terminal domain | 0.2418 | Inherited |
| Calcium ATPase, transmembrane domain M | 0.2418 | Inherited |
| Calcium ATPase, transduction domain A | 0.2516 | Inherited |
| Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) | 0.2628 | Inherited |
| Acetylcholinesterase-like | 0.268 | Inherited |
| GLA-domain | 0.268 | Inherited |
| Serpins | 0.269 | Inherited |
| Tubulin, GTPase domain | 0.2903 | Inherited |
| Toll/Interleukin receptor TIR domain | 0.2903 | Inherited |
| PDI-like | 0.2976 | Inherited |
| Caspase catalytic domain | 0.2976 | Inherited |
| Calpain large subunit, middle domain (domain III) | 0.2976 | Inherited |
| FAD/NAD-linked reductases, N-terminal and central domains | 0.2976 | Inherited |
| Tubulin, C-terminal domain | 0.3142 | Inherited |
| Gonadodropin/Follitropin | 0.3643 | Inherited |
| Rap/Ran-GAP | 0.3643 | Inherited |
| Acetyl-CoA synthetase-like | 0.3751 | Inherited |
| Meta-cation ATPase, catalytic domain P | 0.3952 | Inherited |
| Sm motif of small nuclear ribonucleoproteins, SNRNP | 0.4037 | Inherited |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.4037 | Inherited |
| ets domain | 0.4249 | Inherited |
| N-acetyl transferase, NAT | 0.4251 | Inherited |
| Tropomyosin | 0.4251 | Inherited |
| Transforming growth factor (TGF)-beta | 0.4411 | Inherited |
| C2 set domains | 0.4453 | Inherited |
| Glutathione peroxidase-like | 0.4568 | Inherited |
| Aldo-keto reductases (NADP) | 0.4912 | Inherited |
| Cyclophilin (peptidylprolyl isomerase) | 0.4912 | Inherited |
| A DNA-binding domain in eukaryotic transcription factors | 0.525 | Inherited |
| L domain | 0.5432 | Inherited |
| Plakin repeat | 0.5432 | Inherited |
| MPP-like | 0.5432 | Inherited |
| Choline/Carnitine O-acyltransferase | 0.5432 | Inherited |
| Calpain large subunit, catalytic domain (domain II) | 0.5621 | Inherited |
| NADPH-cytochrome p450 reductase FAD-binding domain-like | 0.6006 | Inherited |
| E2F dimerization segment | 0.6006 | Inherited |
| NADPH-cytochrome p450 reductase-like | 0.6006 | Inherited |
| MHC antigen-recognition domain | 0.6137 | Inherited |
| Dual specificity phosphatase-like | 0.6294 | Inherited |
| Cold shock DNA-binding domain-like | 0.6377 | Inherited |
| C1 set domains (antibody constant domain-like) | 0.6377 | Inherited |
| Group II chaperonin (CCT, TRIC), apical domain | 0.6822 | Inherited |
| Fibronectin type II module | 0.6822 | Inherited |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0.7253 | Inherited |
| Cell cycle transcription factor e2f-dp | 0.7253 | Inherited |
| CCCH zinc finger | 0.7623 | Inherited |
| Elongation factors | 0.7624 | Inherited |
| Pentraxin (pentaxin) | 0.7689 | Inherited |
| Nucleoside diphosphate kinase, NDK | 0.7689 | Inherited |
| Interleukin-1 (IL-1) | 0.7689 | Inherited |
| Voltage-gated potassium channels | 0.7792 | Inherited |
| Nicotinic receptor ligand binding domain-like | 0.7849 | Inherited |
| Small Kunitz-type inhibitors & BPTI-like toxins | 0.7945 | Inherited |
| I set domains | 0.8021 | Inherited |
| Ovomucoid domain III-like | 0.8067 | Inherited |
| Translational machinery components | 0.8123 | Inherited |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.889 | Inherited |
| Cytochrome p450 reductase N-terminal domain-like | 0.898 | Inherited |
| Ran-binding domain | 0.9202 | Inherited |
| S100 proteins | 0.9398 | Inherited |
| Retinol binding protein-like | 0.9398 | Inherited |
| Actin/HSP70 | 0.9462 | Inherited |
| Fibroblast growth factors (FGF) | 0.9562 | Inherited |
| Insulin-like | 0.9723 | Inherited |
| TNF-like | 0.9736 | Inherited |
| Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain | 0.9753 | Inherited |
| Fibrinogen C-terminal domain-like | 0.9813 | Inherited |
| Chaperone J-domain | 0.992 | Inherited |
| Cadherin | 0.9942 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 1 | Inherited |
| Galectin (animal S-lectin) | 1 | Inherited |
| Rhodopsin-like | 1 | Inherited |
| Prefoldin | 1 | Inherited |
| Interferons/interleukin-10 (IL-10) | 1 | Inherited |
| Homeodomain | 1 | Inherited |
| Long-chain cytokines | 1 | Inherited |
| Eukaryotic proteases | 1 | Inherited |
| Intermediate filament protein, coiled coil region | 1 | Inherited |
LINKTO: Domain2BO Download and Domain2BO Algorithm
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Supra-domain (Single)( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| VPS9 domain | 0 | DIRECT |
| Integrin domains | 0 | DIRECT |
| 3-carboxy-cis,cis-mucoante lactonizing enzyme | 0 | DIRECT |
| AXH domain | 0 | DIRECT |
| Amine oxidase catalytic domain | 0 | DIRECT |
| GINS helical bundle-like | 0 | DIRECT |
| Peptidylarginine deiminase Pad4, middle domain | 0 | DIRECT |
| MIR domain | 0 | DIRECT |
| LeuD/IlvD-like | 0 | DIRECT |
| PurM C-terminal domain-like | 0 | DIRECT |
| Leukotriene A4 hydrolase N-terminal domain | 0 | DIRECT |
| Ribonuclease PH domain 2-like | 0 | DIRECT |
| LanC-like | 0 | DIRECT |
| TB module/8-cys domain | 0 | DIRECT |
| USP8 N-terminal domain-like | 0 | DIRECT |
| Class I glutamine amidotransferase-like | 0 | DIRECT |
| A heparin-binding domain | 0 | DIRECT |
| I/LWEQ domain | 0 | DIRECT |
| 4Fe-4S ferredoxins | 0 | DIRECT |
| Translation proteins SH3-like domain | 0 | DIRECT |
| Metallothionein | 0 | DIRECT |
| ValRS/IleRS/LeuRS editing domain | 0 | DIRECT |
| Thiolase-like | 0 | DIRECT |
| PEBP-like | 0 | DIRECT |
| FMT C-terminal domain-like | 0 | DIRECT |
| Putative isomerase YbhE | 0 | DIRECT |
| Zn-finger domain of Sec23/24 | 0 | DIRECT |
| Transcription factor STAT-4 N-domain | 0 | DIRECT |
| CCHHC domain | 0 | DIRECT |
| Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain | 0 | DIRECT |
| WW domain | 0 | DIRECT |
| Apolipoprotein A-I | 0 | DIRECT |
| Sema domain | 0 | DIRECT |
| Formate/glycerate dehydrogenase catalytic domain-like | 0 | DIRECT |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
| Release factor | 0 | DIRECT |
| Phosphoglycerate mutase-like | 0 | DIRECT |
| YWTD domain | 0 | DIRECT |
| AN1-like Zinc finger | 0 | DIRECT |
| Periplasmic binding protein-like II | 0 | DIRECT |
| Gamma-glutamyl cyclotransferase-like | 0 | DIRECT |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
| Integrin beta tail domain | 0 | DIRECT |
| His-Me finger endonucleases | 0 | DIRECT |
| Activating enzymes of the ubiquitin-like proteins | 0 | DIRECT |
| Glutamine synthetase/guanido kinase | 0 | DIRECT |
| occludin/ELL-like | 0 | DIRECT |
| alpha-catenin/vinculin-like | 0 | DIRECT |
| Adenine nucleotide alpha hydrolases-like | 0 | DIRECT |
| Actin-crosslinking proteins | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| BTG domain-like | 0 | DIRECT |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | DIRECT |
| Terpenoid cyclases/Protein prenyltransferases | 0 | DIRECT |
| Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
| Six-hairpin glycosidases | 0 | DIRECT |
| PLP-binding barrel | 0 | DIRECT |
| P-domain of calnexin/calreticulin | 0 | DIRECT |
| PriA/YqbF domain | 0 | DIRECT |
| Pentein | 0 | DIRECT |
| DLC | 0 | DIRECT |
| PRTase-like | 0 | DIRECT |
| Mss4-like | 0 | DIRECT |
| Amine oxidase N-terminal region | 0 | DIRECT |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Creatinase/prolidase N-terminal domain | 0 | DIRECT |
| HIT-like | 0 | DIRECT |
| Fe-S cluster assembly (FSCA) domain-like | 0 | DIRECT |
| Phosphofructokinase | 0 | DIRECT |
| L-aspartase-like | 0 | DIRECT |
| Clathrin adaptor appendage domain | 0 | DIRECT |
| STAT | 0 | DIRECT |
| AlbA-like | 0 | DIRECT |
| Families 57/38 glycoside transferase middle domain | 0 | DIRECT |
| Proteasome activator | 0 | DIRECT |
| Nucleotidylyl transferase | 0 | DIRECT |
| Stathmin | 0 | DIRECT |
| Thyroglobulin type-1 domain | 0 | DIRECT |
| Aminoacid dehydrogenase-like, N-terminal domain | 0 | DIRECT |
| AraD/HMP-PK domain-like | 0 | DIRECT |
| BolA-like | 0 | DIRECT |
| PurM N-terminal domain-like | 0 | DIRECT |
| Uracil-DNA glycosylase-like | 0 | DIRECT |
| Eferin C-derminal domain-like | 0 | DIRECT |
| Galactose mutarotase-like | 0 | DIRECT |
| Endosomal sorting complex assembly domain | 0 | DIRECT |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | DIRECT |
| Lipoxigenase | 0 | DIRECT |
| C-terminal domain of adenylylcyclase associated protein | 0 | DIRECT |
| Anaphylotoxins (complement system) | 0 | DIRECT |
| Subtilisin-like | 0 | DIRECT |
| Ribosomal protein L30p/L7e | 0 | DIRECT |
| Aconitase iron-sulfur domain | 0 | DIRECT |
| RGC domain-like | 0 | DIRECT |
| GAT-like domain | 0 | DIRECT |
| SPOC domain-like | 0 | DIRECT |
| ABC transporter transmembrane region | 0 | DIRECT |
| RmlC-like cupins | 0 | DIRECT |
| L27 domain | 0 | DIRECT |
| EB1 dimerisation domain-like | 0 | DIRECT |
| FMN-binding split barrel | 0 | DIRECT |
| Nucleoplasmin-like core domain | 0 | DIRECT |
| ACT-like | 0 | DIRECT |
| PK beta-barrel domain-like | 0 | DIRECT |
| KA1-like | 0 | DIRECT |
| Delta-sleep-inducing peptide immunoreactive peptide | 0 | DIRECT |
| Serine protease inhibitors | 0 | DIRECT |
| PWI domain | 0 | DIRECT |
| N-terminal domain of cbl (N-cbl) | 0 | DIRECT |
| DNA-binding domain | 0 | DIRECT |
| S13-like H2TH domain | 0 | DIRECT |
| Mediator hinge subcomplex-like | 0 | DIRECT |
| Homocysteine S-methyltransferase | 0 | DIRECT |
| Plexin repeat | 0 | DIRECT |
| BRCT domain | 0 | DIRECT |
| Alpha-macroglobulin receptor domain | 0 | DIRECT |
| Nicotinate/Quinolinate PRTase C-terminal domain-like | 0 | DIRECT |
| Rudiment single hybrid motif | 0 | DIRECT |
| LCCL domain | 0 | DIRECT |
| Indolic compounds 2,3-dioxygenase-like | 0 | DIRECT |
| Heme-dependent peroxidases | 0 | DIRECT |
| PUG domain-like | 0 | DIRECT |
| PIN domain-like | 0 | DIRECT |
| DNA polymerase beta, N-terminal domain-like | 0 | DIRECT |
| SGNH hydrolase | 0 | DIRECT |
| Carbon-nitrogen hydrolase | 0 | DIRECT |
| Carbohydrate phosphatase | 0 | DIRECT |
| S15/NS1 RNA-binding domain | 0 | DIRECT |
| Amidase signature (AS) enzymes | 0 | DIRECT |
| EPT/RTPC-like | 0 | DIRECT |
| Transferrin receptor-like dimerisation domain | 0 | DIRECT |
| Serum albumin-like | 0 | DIRECT |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | DIRECT |
| Transcription factor IIA (TFIIA), beta-barrel domain | 0 | DIRECT |
| ADP-ribosylglycohydrolase | 0 | DIRECT |
| Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
| Cytochrome b5-like heme/steroid binding domain | 0 | DIRECT |
| BAG domain | 0 | DIRECT |
| Peptidase/esterase 'gauge' domain | 0 | DIRECT |
| Mib/herc2 domain-like | 0 | DIRECT |
| Helical domain of Sec23/24 | 0 | DIRECT |
| AhpD-like | 0 | DIRECT |
| Oxysterol-binding protein-like | 0 | DIRECT |
| WGR domain-like | 0 | DIRECT |
| Probable bacterial effector-binding domain | 0 | DIRECT |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
| Single hybrid motif | 0 | DIRECT |
| Transcription factor IIA (TFIIA), alpha-helical domain | 0 | DIRECT |
| Notch domain | 0 | DIRECT |
| Assembly domain of cartilage oligomeric matrix protein | 0 | DIRECT |
| Hermes dimerisation domain | 0 | DIRECT |
| MAPEG domain-like | 0 | DIRECT |
| Clc chloride channel | 0 | DIRECT |
| Nucleotide-binding domain | 0 | DIRECT |
| Nop domain | 0 | DIRECT |
| MOSC N-terminal domain-like | 0 | DIRECT |
| TAFH domain-like | 0 | DIRECT |
| ClpS-like | 0 | DIRECT |
| PAZ domain | 0 | DIRECT |
| Nucleoporin domain | 0 | DIRECT |
| DHS-like NAD/FAD-binding domain | 0 | DIRECT |
| FAD-linked oxidases, C-terminal domain | 0 | DIRECT |
| beta-lactamase/transpeptidase-like | 0 | DIRECT |
| FAD-dependent thiol oxidase | 0 | DIRECT |
| R3H domain | 0 | DIRECT |
| Cu,Zn superoxide dismutase-like | 0 | DIRECT |
| ISP domain | 0 | DIRECT |
| FAD-linked reductases, C-terminal domain | 0 | DIRECT |
| Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
| Ribosomal protein L16p/L10e | 0 | DIRECT |
| FF domain | 0 | DIRECT |
| IP3 receptor type 1 binding core, domain 2 | 0 | DIRECT |
| Cysteine alpha-hairpin motif | 0 | DIRECT |
| PAH2 domain | 0 | DIRECT |
| MgtE membrane domain-like | 0 | DIRECT |
| Connexin43 | 0 | DIRECT |
| HR1 repeat | 0 | DIRECT |
| Alanine racemase C-terminal domain-like | 0 | DIRECT |
| Alpha-L RNA-binding motif | 0 | DIRECT |
| Aminomethyltransferase beta-barrel domain | 0 | DIRECT |
| Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
| Methylglyoxal synthase-like | 0 | DIRECT |
| Inosine monophosphate dehydrogenase (IMPDH) | 0 | DIRECT |
| N-(deoxy)ribosyltransferase-like | 0 | DIRECT |
| Microbial and mitochondrial ADK, insert "zinc finger" domain | 0 | DIRECT |
| FAD-binding/transporter-associated domain-like | 0 | DIRECT |
| 2Fe-2S ferredoxin-like | 0 | DIRECT |
| ITPase-like | 0 | DIRECT |
| Arginase/deacetylase | 0 | DIRECT |
| DNA-glycosylase | 0 | DIRECT |
| Protein prenylyltransferase | 0 | DIRECT |
| RBP11-like subunits of RNA polymerase | 0 | DIRECT |
| MAST3 pre-PK domain-like | 0 | DIRECT |
| Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
| SIS domain | 0 | DIRECT |
| Ribosomal protein S18 | 0 | DIRECT |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | DIRECT |
| alpha/beta knot | 0 | DIRECT |
| Ribosomal proteins S24e, L23 and L15e | 0 | DIRECT |
| TIMP-like | 0 | DIRECT |
| Phosphoglucomutase, first 3 domains | 0 | DIRECT |
| LysM domain | 0 | DIRECT |
| Small-conductance potassium channel | 0 | DIRECT |
| PapD-like | 0 | DIRECT |
| Nitric oxide (NO) synthase oxygenase domain | 0 | DIRECT |
| GHMP Kinase, C-terminal domain | 0 | DIRECT |
| Purine and uridine phosphorylases | 0 | DIRECT |
| Oncogene products | 0 | DIRECT |
| JAB1/MPN domain | 0 | DIRECT |
| Translational machinery components | 0 | DIRECT |
| G protein-binding domain | 0 | DIRECT |
| VHP, Villin headpiece domain | 0 | DIRECT |
| Mannose 6-phosphate receptor domain | 0 | DIRECT |
| DEK C-terminal domain | 0 | DIRECT |
| RNase III domain-like | 0 | DIRECT |
| Rhodanese/Cell cycle control phosphatase | 0 | DIRECT |
| Acyl-CoA dehydrogenase NM domain-like | 0 | DIRECT |
| FAD-linked oxidoreductase | 0 | DIRECT |
| Succinyl-CoA synthetase domains | 0 | DIRECT |
| Glycolipid transfer protein, GLTP | 0 | DIRECT |
| PHM/PNGase F | 0 | DIRECT |
| MIT domain | 0 | DIRECT |
| p53 tetramerization domain | 0 | DIRECT |
| 14-3-3 protein | 0 | DIRECT |
| Seven-hairpin glycosidases | 0 | DIRECT |
| Calcium-dependent phosphotriesterase | 0 | DIRECT |
| ATP-dependent DNA ligase DNA-binding domain | 0 | DIRECT |
| F1F0 ATP synthase subunit C | 0 | DIRECT |
| Di-copper centre-containing domain | 0 | DIRECT |
| HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
| GYF domain | 0 | DIRECT |
| Proton glutamate symport protein | 0 | DIRECT |
| Class II aaRS ABD-related | 0 | DIRECT |
| Ribosomal protein L1 | 0 | DIRECT |
| Guanido kinase N-terminal domain | 0 | DIRECT |
| SCP-like | 0 | DIRECT |
| beta-sandwich domain of Sec23/24 | 0 | DIRECT |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | DIRECT |
| Cation efflux protein transmembrane domain-like | 0 | DIRECT |
| BSD domain-like | 0 | DIRECT |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | DIRECT |
| Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain | 0 | DIRECT |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
| Bcl-2 inhibitors of programmed cell death | 0 | DIRECT |
| PRC-barrel domain | 0 | DIRECT |
| Pseudouridine synthase | 0 | DIRECT |
| Fibrinogen coiled-coil and central regions | 0 | DIRECT |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | DIRECT |
| Ribosomal protein S10 | 0 | DIRECT |
| FKBP-like | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Hect, E3 ligase catalytic domain | 0 | DIRECT |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | DIRECT |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
| Trimeric LpxA-like enzymes | 0 | DIRECT |
| Formyltransferase | 0 | DIRECT |
| Sec7 domain | 0 | DIRECT |
| GFP-like | 0 | DIRECT |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | DIRECT |
| C-terminal domain of PLC-beta | 0 | DIRECT |
| Chicken cartilage matrix protein | 0 | DIRECT |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
| BRK domain-like | 0 | DIRECT |
| BEACH domain | 0 | DIRECT |
| Restriction endonuclease-like | 0 | DIRECT |
| Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | DIRECT |
| FMN-linked oxidoreductases | 0 | DIRECT |
| Troponin coil-coiled subunits | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| Phosphoenolpyruvate/pyruvate domain | 0 | DIRECT |
| GTF2I-like repeat | 0 | DIRECT |
| DUSP-like | 0 | DIRECT |
| Mitochondrial cytochrome c oxidase subunit VIIa | 0 | DIRECT |
| PABC (PABP) domain | 0 | DIRECT |
| Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
| CAD & PB1 domains | 0 | DIRECT |
| Ribosomal L27 protein-like | 0 | DIRECT |
| TSP type-3 repeat | 0 | DIRECT |
| ARID-like | 0 | DIRECT |
| YVTN repeat-like/Quinoprotein amine dehydrogenase | 0 | DIRECT |
| Glycoside hydrolase/deacetylase | 0 | DIRECT |
| Bacterial exopeptidase dimerisation domain | 0 | DIRECT |
| DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
| ALDH-like | 0 | DIRECT |
| P-loop containing nucleoside triphosphate hydrolases | 0.00000003465 | DIRECT |
| ARM repeat | 0.000000103 | DIRECT |
| PH domain-like | 0.000002367 | DIRECT |
| SH3-domain | 0.000004917 | DIRECT |
| EGF/Laminin | 0.00004166 | DIRECT |
| FYVE/PHD zinc finger | 0.000248 | DIRECT |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.0003334 | DIRECT |
| Cytochrome P450 | 0.001103 | INHERITED FROM: Cyclopentane Monoterpenes || Betamethasone || Indenes || 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid || Fluorenes || Dehydroepiandrosterone || HT-2 toxin || 2,6-dimethylnaphthalene || benzo(c)phenanthrene || Cholic Acids || obeticholic acid || Polyketides || Ketosteroids || Anthracenes || 1,2,5,6-dibenzanthracene || Dactinomycin || aloe emodin || 2-Naphthylamine || dimemorfan || fenvalerate || triptolide || Anthraquinones || pyrene || cyhalothrin || Permethrin || Emodin || Cyclobutanes || 1-naphthol || 17-alpha-Hydroxyprogesterone || 5-methylchrysene || Limonene || Pyrethrins || anthracene || deoxynivalenol || Rifamycins || Dextrorphan || trans-1,2-dihydro-1,2-naphthalenediol || sibutramine || S-sulindac || 9,10-Dimethyl-1,2-benzanthracene || Morphinans || 2-nitrofluoranthene || chrysophanic acid || Methyltestosterone || Macrolides || Androstanes || Propranolol || Indans || 1,4-naphthoquinone || 1-phenylazo-2-naphthol || Cyclodextrins || naphthalene || 6-nitrobenzo(a)pyrene || benzo(a)pyrene 7,8-dihydrodiol || 2-methyl-5-isopropenylcyclohex-2-enone oxime || Cyclopentanes || Carbaryl || decamethrin || Phenalenes || Acenaphthenes || Buspirone || Dibenzocycloheptenes || Metalloporphyrins || Benzocycloheptenes || Pregnenes || Dextromethorphan || dibenzoanthracene-3,4-dihydrodiol || Cholanes || 1-chloropyrene || 3,6-dinitrobenzopyrene || 6-chrysenamine || physcione || phenanthrene || Loratadine || Naphthols || Desoxycorticosterone || shikonin || Pregnenediones || 4-oxoretinoic acid || Fused-Ring Compounds || Macrocyclic Compounds || Depsipeptides || Norsteroids || walrycin A || Hydrocortisone || Cholestenes || Clobetasol || Hydroxytestosterones || Alitretinoin || 5,12-naphthacenequinone || alizarin || Spiro Compounds || 6-nitrochrysene || 4-methylchrysene || naphtho(2,3-a)pyrene || 3-methylchrysene || 6-methylchrysene || Cholestanes || Sertraline || Eucalyptol || 2-hydroxyestradiol || Trichothecenes || indeno(1,2,3-cd)pyrene || Phenanthrenes || Naphthalenes || paricalcitol || Dihydroxycholecalciferols || 1,3-dinitropyrene || UAB 30 || 4,4'-cyclohexylidenebisphenol || epoxiconazole || Secosteroids || thiocoraline || acenaphthylene || Calcitriol || Benz(a)Anthracenes || 4-hydroxyretinoic acid || Bile Acids and Salts || Cholestanols || Lactams, Macrocyclic || 1-Naphthylamine || Estrone || Ethers, Cyclic || purpurin || Epoxy Compounds || benzotriphenylene || 9-phenanthrol |
| FAD/NAD(P)-binding domain | 0.001648 | INHERITED FROM: Xanthophylls || Hydroxycholecalciferols || Cyclosporins || Cholestenes || Dihydroxycholecalciferols || Calcitriol || juglone |
| Protein kinase-like (PK-like) | 0.001684 | INHERITED FROM: cyanoginosin LR || Indenes || Spirostans || Iridoids || Cholic Acids || Polyketides || napabucasin || dioscin || Maytansine || Microcystins || 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione || tanespimycin || Sirolimus || 3-O-caffeoyl-1-methylquinic acid || beta-ionone || Polycyclic Aromatic Hydrocarbons || aucubin || chrysophanic acid || Fulvestrant || beta-Cyclodextrins || Macrolides || Androstanes || tamibarotene || Cyclodextrins || methyleugenol-2',3'-epoxide || Camphanes || ethyl 8-oxo-8H-acenaphtho(1,2-b)pyrrole-9-carboxylate || Lycopene || 5H-benzo(4,5)cyclohepta(1,2-b)pyridin-5-one || Benzocycloheptenes || Cholanes || 3-(2-(dimethylamino)isopropoxy)-1-hydroxybenzo(b)naphtho(2,3-d)furan-6,11-dione || Pyrenes || liposomal doxorubicin || NSC 680410 || Win 55212-2 || Sapogenins || Cardiac Glycosides || Diosgenin || Naphthalenes || Cyclohexane Monoterpenes || tylophorine || Ouabain || Bile Acids and Salts || Cardanolides || Lactams, Macrocyclic || Iridoid Glycosides || Cyclodecanes || 4-acetylantroquinonol B || picropodophyllin |
| PDZ domain-like | 0.001722 | INHERITED FROM: Polycyclic Aromatic Hydrocarbons || benzo(e)pyrene |
| Growth factor receptor domain | 0.001937 | INHERITED FROM: napabucasin || 9,10-dihydro-9,10-dihydroxybenzo(a)pyrene || Hydroxycholecalciferols || Paclitaxel || Medroxyprogesterone || Medroxyprogesterone Acetate || Pregnenediones || Norsteroids || Dihydroxycholecalciferols || Calcitriol || Cyclodecanes |
| Nuclear receptor ligand-binding domain | 0.004168 | INHERITED FROM: Cyclopentane Monoterpenes || Betamethasone || Indenes || 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid || tetralin || Fluorenes || Dehydroepiandrosterone || Cardenolides || Cyproterone Acetate || GSK 8470 || Cholic Acids || eldecalcitol || Polyketides || Ketosteroids || Anthracenes || fenvalerate || Prednisolone || 3-benzylidene camphor || pyrene || cyhalothrin || Cyclohexanecarboxylic Acids || Permethrin || Chenodeoxycholic Acid || 3-acetyldeoxynivalenol || Corticosterone || Valinomycin || 5-alpha-Dihydroprogesterone || Pyrethrins || Cholesterol || Bridged-Ring Compounds || Simvastatin || Mifepristone || Rifamycins || LG 100268 || tibolone || versalide || SR 11237 || 2,2-bis(4-glycidyloxyphenyl)propane || Fulvestrant || Promegestone || ethofenprox || Cycloparaffins || Androstanes || 1-hydroxypyrene || phantolid || Indans || 1-Naphthylisothiocyanate || Medroxyprogesterone || Digitoxin || Cyclopentanes || Epirubicin || Hydroxycholesterols || Carbaryl || diisononyl 1,2-cyclohexanedicarboxylic acid || 9-cis-retinal || 2,6-diisopropylnaphthalene || Budesonide || calcipotriene || Cyproterone || Bexarotene || Toxaphene || Cyclohexenes || Norethindrone Acetate || Medroxyprogesterone Acetate || Abietanes || Fenretinide || Cholanes || Carotenoids || Steroids, Heterocyclic || 4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid || Naphthols || beta Carotene || Pregnanediones || Fused-Ring Compounds || Macrocyclic Compounds || Bridged Bicyclo Compounds || Ciclopirox || Equilin || Retinoids || pirarubicin || Sterols || Depsipeptides || Cortodoxone || Retinaldehyde || Cholestenes || acetyl methyl tetramethyl tetralin || Cardiac Glycosides || Pregnadienediols || Alitretinoin || sulindac sulfone || AGN 193109 || dihydroxy-vitamin D3 || enzacamene || Camphor || Cholestanes || Digitalis Glycosides || Trichothecenes || Idarubicin || Phenanthrenes || 1,1-bis(4-hydroxyphenyl)cyclohexane || Naphthalenes || Oxymetholone || paricalcitol || Steroids, Chlorinated || temsirolimus || ciclesonide || Triamcinolone || Danazol || 4-hydroxyretinoic acid || Bile Acids and Salts || Cardanolides || Lactams, Macrocyclic || phenothrin || Megestrol || Estrone || Ethers, Cyclic || Estriol |
| TSP-1 type 1 repeat | 0.005093 | INHERITED FROM: Benzopyrenes || Paclitaxel || Methylprednisolone || benzo(e)pyrene |
| Ubiquitin-like | 0.005143 | INHERITED FROM: Benzopyrenes |
| GTPase activation domain, GAP | 0.005325 | INHERITED FROM: Polycyclic Aromatic Hydrocarbons || 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
| Metalloproteases ("zincins"), catalytic domain | 0.006739 | INHERITED FROM: Tetracyclines || Simvastatin || Mifepristone || 1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one || 3-caffeoyl-4-dihydrocaffeoylquinic acid || cyclo(Trp-Asp-Pro-Val-Leu) || manganese(III)-tetrakis(4-benzoic acid)porphyrin || pyrazolanthrone || Pregnenes || Doxycycline || Pregnenediones || Progesterone || mibolerone |
| Interleukin 8-like chemokines | 0.007014 | INHERITED FROM: Betamethasone || Fluorenes || Cardenolides || Polyketides || Prednisolone || 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol || beta-hydroxy simvastatin acid || Tetracyclines || Cholesterol || Phytosterols || Simvastatin || Mifepristone || 1-nitropyrene || Morphine Derivatives || Morphinans || Norbornanes || Fulvestrant || Withanolides || Lanatosides || Methylprednisolone || Digoxin || Bicyclic Monoterpenes || Digitoxin || Roflumilast || roflumilast N-oxide || Antimycin A || Fludrocortisone || primycin || Camphanes || Budesonide || butenafine || Terbinafine || Strophanthins || Beclomethasone || Chrysenes || Dibenzocycloheptenes || Benzocycloheptenes || Proscillaridin || Pregnenes || BIRB 796 || Cholestenones || beta Carotene || Pregnenediones || Bridged Bicyclo Compounds || 3-nitrofluoranthene || Sterols || pevonedistat || Cholestenes || 3-aminofluoranthene || Ursodeoxycholic Acid || enzacamene || Ergosterol || Digitalis Glycosides || Minocycline || Trichothecenes || Phenanthrenes || Steroids, Chlorinated || Bufanolides || Cyclopropanes || coagulin-L || meclocycline || Digitoxigenin || Oxytetracycline || sirtinol |
| Bromodomain | 0.009052 | INHERITED FROM: Pregnadienes || Cyproterone Acetate || deoxynivalenol || Cyproterone || Trichothecenes |
| GST C-terminal domain-like | 0.01327 | INHERITED FROM: apocarotenal || Ketosteroids || Microcystins || apple polyphenol extract || Tetrapyrroles || Bile Pigments || microcystin RR || beta Carotene || Androstenedione || dibenzo(a,l)pyrene || Spiro Compounds || Naphthalenesulfonates || Okadaic Acid || 17-Ketosteroids |
| SH2 domain | 0.01897 | INHERITED FROM: benzo(a)pyrene-3,6-quinone || Simvastatin || Cyclohexanones || tamibarotene || caryophyllene || benzo(a)pyrene-1,6-quinone || Naphthalenes || naphtho(1,2-b)furan-4,5-dione || 4-acetylantroquinonol B |
| NAD(P)-binding Rossmann-fold domains | 0.02012 | INHERITED FROM: 9,10-phenanthrenequinone || Ketosteroids || Polycyclic Aromatic Hydrocarbons || Cortisone || Androstenediols || 1,2-naphthoquinone || Androstenediol || Androstenedione || bifenthrin || Macrocyclic Compounds || Retinoids || Isotretinoin || Estrone |
| Second domain of FERM | 0.02457 | INHERITED FROM: Benzopyrenes || Pyrenes |
| PYP-like sensor domain (PAS domain) | 0.02786 | INHERITED FROM: Fluorenes || Cyproterone Acetate || eldecalcitol || Polyketides || Rifamycins || Benzopyrenes || Fulvestrant || Digoxin || Cyclopentanes || Cyproterone || Pyrenes || Bridged Bicyclo Compounds || dihydroxy-vitamin D3 || azaspiracid || Digitalis Glycosides || Rifampin || Ouabain || Lactams, Macrocyclic |
| Calponin-homology domain, CH-domain | 0.02984 | INHERITED FROM: Polycyclic Aromatic Hydrocarbons || Fused-Ring Compounds |
| Alkaline phosphatase-like | 0.03551 | INHERITED FROM: Oxocins || yessotoxin |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.03616 | INHERITED FROM: Bryostatins || Pyrenes |
| Ras GEF | 0.04001 | INHERITED FROM: Strophanthins || Ouabain |
| Mitochondrial carrier | 0.05749 | INHERITED FROM: enniatins || dehydroabietylamine || Sesquiterpenes, Guaiane || Cycloheptanes || Abietanes || Sesquiterpenes, Eudesmane || CD 437 || Thapsigargin || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Polycyclic Sesquiterpenes |
| Fibronectin type III | 0.05852 | INHERITED FROM: Simvastatin || Cycloparaffins || Pyrenes || Pregnenediones || benzo(e)pyrene |
| Galactose-binding domain-like | 0.05899 | INHERITED FROM: Desogestrel |
| SNARE fusion complex | 0.06418 | INHERITED FROM: Morphine Derivatives || Morphinans || Heroin |
| HD-domain/PDEase-like | 0.07202 | INHERITED FROM: Cyclohexanecarboxylic Acids || Roflumilast || Cilomilast || Cyclopropanes |
| TNF receptor-like | 0.08083 | INHERITED FROM: Spirostans || aloe emodin || dioscin || Menthol || Nystatin || Cycloparaffins || Paclitaxel || Cyclohexanols || Cyclohexanes || 4-(3-(1-adamantyl)-4-hydroxyphenyl)-3-chlorocinnamic acid || 2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyc || Diosgenin || Cyclohexane Monoterpenes || motexafin gadolinium || Epoxy Compounds |
| ADP-ribosylation | 0.08083 | INHERITED FROM: N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride || Phenanthrenes |
| Cysteine-rich domain | 0.08864 | INHERITED FROM: Emodin || Bryostatins || Ouabain |
| Integrin alpha N-terminal domain | 0.09058 | INHERITED FROM: napabucasin || Tetracyclines || Lithocholic Acid || Pregnenes || Pregnenediones || Progesterone || Tetracycline |
| Hemopexin-like domain | 0.09058 | INHERITED FROM: Anthracenes || Tetracyclines || Simvastatin || bufalin || Mifepristone || 1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one || 3-caffeoyl-4-dihydrocaffeoylquinic acid || Lovastatin || Wortmannin || Tetrapyrroles || cyclo(Trp-Asp-Pro-Val-Leu) || Paclitaxel || manganese(III)-tetrakis(4-benzoic acid)porphyrin || pyrazolanthrone || Chlorogenic Acid || Doxycycline || Pregnenediones || Progesterone || Cardiac Glycosides || Spiro Compounds || Porphyrins || Estranes || Ouabain || Cardanolides || Cyclodecanes || Estradiol |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.1007 | INHERITED FROM: Microcystins || microcystin RR |
| Sm-like ribonucleoproteins | 0.1014 | INHERITED FROM: Adamantane || Bridged-Ring Compounds || CD 437 || Oxocins || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || yessotoxin || Ethers, Cyclic |
| Ran binding protein zinc finger-like | 0.1014 | INHERITED FROM: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
| Ribosomal protein S5 domain 2-like | 0.1108 | INHERITED FROM: tamibarotene || CD 437 |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.1108 | INHERITED FROM: Cardenolides || Strophanthins || Cardiac Glycosides || Ouabain || Cardanolides |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0.1137 | INHERITED FROM: tamibarotene || Sesquiterpenes, Guaiane || Sesquiterpenes, Eudesmane || Thapsigargin || Estradiol |
| GroES-like | 0.1137 | INHERITED FROM: apocarotenal || Naphthols || walrycin A || Benz(a)Anthracenes |
| UDP-Glycosyltransferase/glycogen phosphorylase | 0.1144 | INHERITED FROM: anthrarobin || Cholic Acids || Anthralin || Ketosteroids || Anthracenes || Anthraquinones || Cyclohexanecarboxylic Acids || 1-naphthol || Naproxen || Morphine || Morphine Derivatives || 1,4-dihydroxyanthraquinone || Morphinans || 2-Methoxyestradiol || 1-hydroxypyrene || 1,2,5,8-tetrahydroxy anthraquinone || 4-hydroxyestrone || alloin || Naphthaleneacetic Acids || plumbagin || Dibenzocycloheptenes || Benzocycloheptenes || Cholanes || Loratadine || Naphthols || shikonin || 2,6-dihydroxyanthraquinone || Pregnenolone || dibenzo(a,l)pyrene || Hydroxyestrones || Androsterone || alizarin || sulindac sulfone || Spiro Compounds || Sulindac || 2-hydroxyestradiol || Phenanthrenes || ranirestat || Naphthalenes || Pregnenolone Carbonitrile || Benz(a)Anthracenes || Methylcholanthrene || Bile Acids and Salts || Estrone || 3-hydroxydesloratadine || Deoxycholic Acid || Cyproheptadine || Estriol |
| Frizzled cysteine-rich domain | 0.127 | INHERITED FROM: Tretinoin || Vitamin A || Mifepristone || Cyclohexanes || Fused-Ring Compounds || Retinoids || Pregnadienetriols || Dexamethasone || Mitoxantrone |
| Nucleic acid-binding proteins | 0.1296 | INHERITED FROM: beauvericin || Quinic Acid || Adamantane || Bridged-Ring Compounds || Sesquiterpenes, Guaiane || Cycloheptanes || Sesquiterpenes, Eudesmane || CD 437 || Thapsigargin || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid || Polycyclic Sesquiterpenes |
| FnI-like domain | 0.133 | INHERITED FROM: Dactinomycin || Prednisolone || Simvastatin || Lovastatin || Tetrapyrroles || Pregnenediones || Pregnadienetriols || Norsteroids || Porphyrins |
| SNF-like | 0.1417 | INHERITED FROM: Cyclohexylamines || Cyclohexanones || 2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone || Indans || indatraline |
| PGBD-like | 0.1417 | INHERITED FROM: Anthracenes || Cyclohexanecarboxylic Acids || Tetracyclines || Simvastatin || bufalin || Mifepristone || 1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one || 3-caffeoyl-4-dihydrocaffeoylquinic acid || Androstadienes || Lovastatin || Wortmannin || Tetrapyrroles || cyclo(Trp-Asp-Pro-Val-Leu) || Hydroxycholecalciferols || Paclitaxel || manganese(III)-tetrakis(4-benzoic acid)porphyrin || pyrazolanthrone || Chlorogenic Acid || Doxycycline || Cholestenones || Pregnenediones || Progesterone || Sterols || Cholestenes || Cardiac Glycosides || Spiro Compounds || Porphyrins || Dihydroxycholecalciferols || Secosteroids || Ouabain || mibolerone || Nandrolone || Calcitriol || Cardanolides || Cyclodecanes || Estradiol |
| Cupredoxins | 0.1417 | INHERITED FROM: ethinyl estradiol-desogestrel combination || Desogestrel || Norpregnatrienes |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.1417 | INHERITED FROM: Tacrolimus |
| Riboflavin synthase domain-like | 0.1417 | INHERITED FROM: Tacrolimus |
| RNA-binding domain, RBD | 0.1489 | INHERITED FROM: 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol || Dihydroxydihydrobenzopyrenes || 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide || yessotoxin || pateamine A |
| Leucine zipper domain | 0.1494 | INHERITED FROM: cyanoginosin LR || LG 100815 || Cholic Acids || Anthracenes || Bridged-Ring Compounds || 1-nitropyrene || 9,10-dihydro-9,10-dihydroxybenzo(a)pyrene || Tetrapyrroles || diphenylcyclopropenone || Withanolides || tamibarotene || Sesquiterpenes, Guaiane || nodularin || Cycloheptanes || Carbaryl || Camphanes || Cyclohexenes || Hemin || Sesquiterpenes, Eudesmane || Cholanes || Cyclosporins || Pregnenediones || tauroursodeoxycholic acid || Macrocyclic Compounds || Retinoids || withaferin A || Cholestenes || Thapsigargin || Norpregnatrienes || Brefeldin A || SR 144528 || Sertraline || Sulindac || Trichothecenes || Naphthalenes || Cyclopropanes || Bile Acids and Salts || 1-Naphthylamine || Estradiol || Polycyclic Sesquiterpenes |
| SMAD/FHA domain | 0.1494 | INHERITED FROM: Iridoids || Benzopyrenes || Aristolochic Acids || aucubin || Iridoid Glucosides || Iridoid Glycosides || sirtinol |
| Cyclin-like | 0.1572 | INHERITED FROM: Indenes || 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid || Brassinosteroids || Cardenolides || Polyketides || Phytosterols || LG 100268 || Wortmannin || Fulvestrant || 2-Methoxyestradiol || Hydroxycholecalciferols || Macrolides || Paclitaxel || HS 1200 || Fenretinide || HS-1199 || Steroids, Heterocyclic || HS 1183 || Taxoids || HS 1030 || Depsipeptides || AGN 194204 || Ursodeoxycholic Acid || Spiro Compounds || apicidin || Sulindac || Dihydroxycholecalciferols || tylophorine || brassinolide || Calcitriol || seocalcitol || Ethers, Cyclic || Cyclodecanes || inecalcitol |
| PLP-dependent transferases | 0.1572 | INHERITED FROM: Naphthoquinones || Cyclosporins |
| Thioredoxin-like | 0.1582 | INHERITED FROM: apocarotenal || Ketosteroids || Microcystins || Quinic Acid || apple polyphenol extract || Tetrapyrroles || dichlone || Chlorophyllides || Bile Pigments || microcystin RR || Cholanes || captafol || beta Carotene || Macrocyclic Compounds || dibenzo(a,l)pyrene || Spiro Compounds || Bile Acids and Salts || 17-Ketosteroids || Ethers, Cyclic |
| DBL homology domain (DH-domain) | 0.1761 | INHERITED FROM: Cholecalciferol || Hydroxycholecalciferols || benzo(e)pyrene || Dihydroxycholecalciferols || Calcitriol || Estradiol |
| SNARE-like | 0.1895 | INHERITED FROM: yessotoxin |
| DEATH domain | 0.1919 | INHERITED FROM: Spirostans || Cholic Acids || Polyketides || Anthracenes || Dactinomycin || aloe emodin || danthron || Anthraquinones || Pyrethrins || bis(acetato)(1-adamantylamine)amminedichloroplatinum(IV) || Bridged-Ring Compounds || 1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one || Acitretin || Menthol || Nystatin || Lovastatin || Cyclohexanones || Tetrapyrroles || Cycloparaffins || Macrolides || Cyclohexanols || nodularin || Digitoxin || Cyclopentanes || cypermethrin || Fenretinide || Cholanes || 4-(3-(1-adamantyl)-4-hydroxyphenyl)-3-chlorocinnamic acid || methyl 5-chloro-4,5-didehydrojasmonate || Aclarubicin || dehydroxymethylepoxyquinomicin || beta Carotene || tauroursodeoxycholic acid || 2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyc || Win 55212-2 || cinobufotalin || Taxoids || Oxocins || Depsipeptides || brevetoxin 2 || Cardiac Glycosides || Epichlorohydrin || Porphyrins || Cholestanes || Diosgenin || Sulindac || Phenanthrenes || pregna-4,17-diene-3,16-dione || Naphthalenes || Cyclohexane Monoterpenes || tylophorine || Bile Acids and Salts || indioside D || Ethers, Cyclic || Cyclodecanes |
| Histone-fold | 0.1922 | INHERITED FROM: MT19c compound || Naphthoquinones || Ergocalciferols |
| DNA/RNA polymerases | 0.1969 | INHERITED FROM: diepoxybutane || Phenalenes || Perylene || Benz(a)Anthracenes || Epoxy Compounds |
| Periplasmic binding protein-like I | 0.1977 | INHERITED FROM: Dizocilpine Maleate || Dibenzocycloheptenes |
| vWA-like | 0.2026 | INHERITED FROM: Medroxyprogesterone || Medroxyprogesterone Acetate || Pregnenes || Pregnenediones || Cyclodecanes |
| Calcium ATPase, transmembrane domain M | 0.2132 | INHERITED FROM: Cardenolides || Strophanthins || Ouabain |
| L30e-like | 0.2199 | INHERITED FROM: Ethers, Cyclic |
| Caspase-like | 0.2199 | INHERITED FROM: Indenes || Spirostans || Cholic Acids || WP 631 || Polyketides || Anthracenes || Ketamine || Dactinomycin || cobaltiprotoporphyrin || Taurocholic Acid || alantolactone || Anthraquinones || zinc protoporphyrin || Cyclohexanecarboxylic Acids || Chenodeoxycholic Acid || Glycochenodeoxycholic Acid || surfactin peptide || Adamantane || Glycodeoxycholic Acid || Pyrethrins || Bridged-Ring Compounds || Morphine || deoxynivalenol || 1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one || Acitretin || Menthol || Morphine Derivatives || Androstadienes || Lovastatin || Wortmannin || Cyclohexanones || 2-Methoxyestradiol || sulindac sulfide || Xanthophylls || Hydroxycholecalciferols || Macrolides || manganese(III)-tetrakis(4-benzoic acid)porphyrin || Propranolol || Cyclohexanols || 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole || Sesquiterpenes, Guaiane || Cycloheptanes || Digitoxin || Cyclopentanes || diepoxybutane || Epirubicin || pyrazolanthrone || 1,4-anthraquinone || cypermethrin || Cyclohexanes || Taurochenodeoxycholic Acid || Fenretinide || Dibenzocycloheptenes || Sesquiterpenes, Eudesmane || Benzocycloheptenes || Cholanes || Donepezil || Loratadine || methyl 5-chloro-4,5-didehydrojasmonate || dehydroxymethylepoxyquinomicin || CD 437 || tauroursodeoxycholic acid || NSC 680410 || 2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyc || Fused-Ring Compounds || Win 55212-2 || cinobufotalin || Taxoids || Sapogenins || Depsipeptides || Vitamin K || echinocystic acid || Cardiac Glycosides || Taurodeoxycholic Acid || Spiro Compounds || Amantadine || methyl protodioscin || apicidin || Cholestanes || Sertraline || Diosgenin || Sulindac || Trichothecenes || Phenanthrenes || pregna-4,17-diene-3,16-dione || Naphthalenes || Dihydroxycholecalciferols || Cyclohexane Monoterpenes || Rifampin || Bufanolides || Oleanolic Acid || Calcitriol || Glycocholic Acid || Bile Acids and Salts || Cardanolides || Lactams, Macrocyclic || indioside D || 1-Naphthylamine || bafilomycin A1 || Ethers, Cyclic || Deoxycholic Acid || Cyclodecanes || Cyproheptadine || Epoxy Compounds || Estradiol || Polycyclic Sesquiterpenes |
| (Phosphotyrosine protein) phosphatases II | 0.2218 | INHERITED FROM: Benzo(a)pyrene || Sertraline || 1-Naphthylamine |
| Kringle-like | 0.225 | INHERITED FROM: ethinyl estradiol-desogestrel combination || Iridoids || Dactinomycin || Taurocholic Acid || Norpregnenes || genipin || Simvastatin || Tetrapyrroles || Propranolol || Medroxyprogesterone || Strophanthins || Beclomethasone || Medroxyprogesterone Acetate || Pregnenediones || Progesterone || alpha-benzoylamino-1,4-naphthoquinone || Sapogenins || Porphyrins || Steroids, Chlorinated || Gestodene || Oleanolic Acid || Ouabain || Hydroxyprogesterones |
| Toll/Interleukin receptor TIR domain | 0.225 | INHERITED FROM: 9,10-dihydro-2,5-dimethoxyphenanthrene-1,7-diol || Paclitaxel || Ivermectin || Cyclodecanes |
| Calcium ATPase, transduction domain A | 0.2292 | INHERITED FROM: Cardenolides || Strophanthins || Cardiac Glycosides || Ouabain |
| Serpins | 0.2292 | INHERITED FROM: ethinyl estradiol-desogestrel combination || Cholic Acids || 2,3-dimethoxy-1,4-naphthoquinone || Norpregnenes || Hydroxycholecalciferols || 1-Naphthylisothiocyanate || Norsteroids || Cholestenes || Alitretinoin || Estranes || Dihydroxycholecalciferols || Rifampin || Calcitriol |
| GLA-domain | 0.2441 | INHERITED FROM: ethinyl estradiol-desogestrel combination || Norpregnenes || dienogest || estradiol valerate-dienogest || norgestimate, ethinyl estradiol drug combination || Medroxyprogesterone || Medroxyprogesterone Acetate || estradiol, norethindrone drug combination || Pregnenediones || Norsteroids || Norpregnatrienes || Gestodene || Nandrolone |
| Class II aaRS and biotin synthetases | 0.2445 | INHERITED FROM: Sesquiterpenes, Guaiane || Cycloheptanes || Sesquiterpenes, Eudesmane || Thapsigargin || Polycyclic Sesquiterpenes |
| Tubulin nucleotide-binding domain-like | 0.2665 | INHERITED FROM: 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol || Sesquiterpenes, Guaiane || Cycloheptanes || Sesquiterpenes, Eudesmane || dibenzo(a,l)pyrene || Thapsigargin || Polycyclic Sesquiterpenes |
| Calpain large subunit, middle domain (domain III) | 0.2723 | INHERITED FROM: glycidamide || Menthol || Cyclohexanols || Cyclohexane Monoterpenes || Epoxy Compounds |
| p53-like transcription factors | 0.2735 | INHERITED FROM: benzo(a)pyrene-3,6-quinone || WP 744 || Polyketides || Dactinomycin || Oxysterols || 2-Acetylaminofluorene || Bridged-Ring Compounds || Simvastatin || Morphine || deoxynivalenol || Morphine Derivatives || Cyclohexanones || Norbornanes || Macrolides || Methylprednisolone || Cyclopentanes || Acenaphthenes || 2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyc || Sapogenins || pevonedistat || benzo(a)pyrene-1,6-quinone || Diosgenin || Trichothecenes || 1-Naphthylamine |
| E set domains | 0.2833 | INHERITED FROM: Naphthalenes || Ketocholesterols |
| Tubulin C-terminal domain-like | 0.2883 | INHERITED FROM: 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol || Sesquiterpenes, Guaiane || Cycloheptanes || Sesquiterpenes, Eudesmane || dibenzo(a,l)pyrene || Thapsigargin || Polycyclic Sesquiterpenes |
| TRAF domain-like | 0.2883 | INHERITED FROM: Menthol || Cyclohexanols || Cyclohexane Monoterpenes |
| Aldolase | 0.3021 | INHERITED FROM: Cholic Acids || obeticholic acid || Chenodeoxycholic Acid || Cyclosporins || Estranes || Peptides, Cyclic || Deoxycholic Acid |
| Cystine-knot cytokines | 0.303 | INHERITED FROM: Cardenolides || Prednisone || Tetracyclines || Simvastatin || Morphinans || aristolochic acid I || MOPP protocol || Strophanthins || Medroxyprogesterone Acetate || Plicamycin || Pregnenediones || Progesterone || Fused-Ring Compounds || Octreotide || Levonorgestrel || Oxocins || Cardiac Glycosides || Pregnadienediols || Alitretinoin || Estranes || Phenanthrenes || Digoxigenin || Protoporphyrins || Estradiol |
| MFS general substrate transporter | 0.322 | INHERITED FROM: Dehydroepiandrosterone || Ketosteroids || Erythromycin || Taurocholic Acid || Spironolactone || Tetracyclines || Naproxen || Rifamycins || Nateglinide || Propranolol || Budesonide || Dehydroepiandrosterone Sulfate || Naphthaleneacetic Acids || Fluoresceins || 7-(deoxyguanosin-N(2)-yl)aristolactam I || Cholic Acid || estrone sulfate || Estranes || 6-carboxyfluorescein || Rifampin || 7-(deoxyadenosin-N(6)-yl)aristolactam I || Amitriptyline || Lactams, Macrocyclic || estradiol-17 beta-glucuronide || Estrone |
| CoA-dependent acyltransferases | 0.3353 | INHERITED FROM: Cholic Acids || Cholanes || Bile Acids and Salts || Isotretinoin || Deoxycholic Acid |
| Rap/Ran-GAP | 0.3353 | INHERITED FROM: Dihydroxydihydrobenzopyrenes |
| TPR-like | 0.343 | INHERITED FROM: Cyclosporins || Peptides, Cyclic |
| Acetyl-CoA synthetase-like | 0.3466 | INHERITED FROM: Cholic Acids || obeticholic acid || Deoxycholic Acid |
| Nucleotidyltransferase | 0.3652 | INHERITED FROM: Prednisolone || Methylprednisolone |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.3717 | INHERITED FROM: aurin || Polyketides || Cyclohexanecarboxylic Acids || Tetrapyrroles || Sesquiterpenes, Guaiane || Sesquiterpenes, Eudesmane || Ivermectin || Thapsigargin || Porphyrins || Naphthalenes || Thiostrepton || Polycyclic Sesquiterpenes |
| Zn-binding ribosomal proteins | 0.3717 | INHERITED FROM: Adamantane || Bridged-Ring Compounds || CD 437 || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid |
| Orange domain-like | 0.3717 | INHERITED FROM: Sesquiterpenes, Guaiane || Cycloheptanes || Sesquiterpenes, Eudesmane || Thapsigargin || Polycyclic Sesquiterpenes |
| Tropomyosin | 0.3934 | INHERITED FROM: Mitoxantrone |
| Glycerol-3-phosphate (1)-acyltransferase | 0.3934 | INHERITED FROM: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
| LDL receptor-like module | 0.4212 | INHERITED FROM: tanshinone |
| Cyclophilin-like | 0.4244 | INHERITED FROM: Oxocins || yessotoxin |
| NAD(P)-linked oxidoreductase | 0.457 | INHERITED FROM: 4-hydroxyequilenin-o-quinone || Indenes || Tetralones || Fluorenes || benzo(a)pyrene-3,6-quinone || 9,10-phenanthrenequinone || Cholic Acids || Ketosteroids || cyclopentanone || Azasteroids || Pregnanolone || Corticosterone || 5-alpha-Dihydroprogesterone || glycidamide || Naproxen || 5-dihydrodeoxycorticosterone || Benzopyrenes || 9,10-dihydro-9,10-dihydroxybenzo(a)pyrene || benzo(a)pyrene-7,8-dione || 3-aminobenzanthrone || 3-nitrobenzanthrone || tetrahydrodeoxycorticosterone || Medroxyprogesterone || benzo(a)pyrene 7,8-dihydrodiol || 20-alpha-Dihydroprogesterone || 9-cis-retinal || Medroxyprogesterone Acetate || Chrysenes || Acenaphthenes || Naphthaleneacetic Acids || Dydrogesterone || Cholanes || Steroids, Heterocyclic || Pyrenes || 1,2-naphthoquinone || tetralol || Desoxycorticosterone || Pregnanediones || Dutasteride || dibenzo(a,l)pyrene || acenaphthene-1-ol || Retinaldehyde || cyclopentanol || 16-ketoestrone || benzo(a)pyrene-1,6-quinone || N-hydroxy-3-aminobenzanthrone || Phenanthrenes || Naphthalenes || Hydroxysteroids || Equilenin || Benz(a)Anthracenes || Bile Acids and Salts || daunorubicinol || Estrone || Ethers, Cyclic || Deoxycholic Acid |
| A DNA-binding domain in eukaryotic transcription factors | 0.4895 | INHERITED FROM: Tretinoin || Cholic Acids || obeticholic acid || Vitamin A || deoxynivalenol || 9,10-dihydro-9,10-dihydroxybenzo(a)pyrene || Tetrapyrroles || Hemin || Cholanes || Retinoids || Vitamin K || Spiro Compounds || Sertraline || Trichothecenes || Rifampin || Bile Acids and Salts || 1-Naphthylamine || Deoxycholic Acid || Vitamin K 3 || Epoxy Compounds |
| SAP domain | 0.5004 | INHERITED FROM: testosterone-3-carboxymethyloxime-bovine serum albumin conjugate || Metribolone |
| Ferritin-like | 0.5065 | INHERITED FROM: Paclitaxel || Cyclodecanes |
| Plakin repeat | 0.5065 | INHERITED FROM: Cholecalciferol || Hydroxycholecalciferols || Sterols || Cholestenes || Dihydroxycholecalciferols || Calcitriol |
| LuxS/MPP-like metallohydrolase | 0.5065 | INHERITED FROM: Isotretinoin |
| (Trans)glycosidases | 0.5459 | INHERITED FROM: Oxocins || yessotoxin |
| Polo-box domain | 0.5632 | INHERITED FROM: Dihydroxydihydrobenzopyrenes || 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
| GroEL apical domain-like | 0.5643 | INHERITED FROM: Adamantane || Ivermectin || CD 437 || Okadaic Acid || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid |
| PAP/OAS1 substrate-binding domain | 0.5643 | INHERITED FROM: Prednisolone || tamibarotene || Methylprednisolone |
| GroEL equatorial domain-like | 0.5643 | INHERITED FROM: Adamantane || Ivermectin || CD 437 || Okadaic Acid || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid |
| MHC antigen-recognition domain | 0.5779 | INHERITED FROM: Erythromycin || Tetracyclines || tamibarotene || Tetrahydronaphthalenes || Minocycline || Naphthalenes || Isotretinoin |
| HMA, heavy metal-associated domain | 0.6241 | INHERITED FROM: Naphthalenes |
| Multidrug efflux transporter AcrB transmembrane domain | 0.6444 | INHERITED FROM: Cholesterol || Simvastatin || Lovastatin |
| GroEL-intermediate domain like | 0.6444 | INHERITED FROM: Adamantane || Bridged-Ring Compounds || Ivermectin || CD 437 || Okadaic Acid || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid |
| "Winged helix" DNA-binding domain | 0.6667 | INHERITED FROM: mibolerone |
| Nucleoside diphosphate kinase, NDK | 0.6866 | INHERITED FROM: Menthol || Cyclohexane Monoterpenes |
| alpha/beta-Hydrolases | 0.691 | INHERITED FROM: Morphine Derivatives || 6-O-monoacetylmorphine || Heroin |
| CCCH zinc finger | 0.723 | INHERITED FROM: 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol |
| EF-hand | 0.7278 | INHERITED FROM: benzo(e)pyrene |
| Flavoproteins | 0.7286 | INHERITED FROM: Fluorenes || Polyketides || Simvastatin || Mifepristone || Androstadienes || Wortmannin || Tetrapyrroles || Chrysenes || Porphyrins || Phenanthrenes || Benz(a)Anthracenes |
| Lipocalins | 0.7466 | INHERITED FROM: 11-(dansylamino)undecanoic acid || Dansyl Compounds || 4-oxoretinoic acid || Naphthalenesulfonates || 1-anilino-8-naphthalenesulfonate || Anilino Naphthalenesulfonates |
| ClpP/crotonase | 0.7493 | INHERITED FROM: Isotretinoin |
| Translation proteins | 0.7704 | INHERITED FROM: Metribolone |
| E2F-DP heterodimerization region | 0.7716 | INHERITED FROM: Menthol || Paclitaxel || Cyclohexanols || Naphthalenes || Cyclohexane Monoterpenes |
| Kazal-type serine protease inhibitors | 0.8012 | INHERITED FROM: estrone sulfate |
| Voltage-gated potassium channels | 0.8487 | INHERITED FROM: Mibefradil || Propranolol |
| Nicotinic receptor ligand binding domain-like | 0.8501 | INHERITED FROM: carvone || Pregnanolone || Rocuronium || Bridged-Ring Compounds || 13,19-didesmethyl spirolide C || beta-thujone || menthone || N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline || Vecuronium Bromide || Picrotoxin || Pancuronium || Camphor || tetramethylenedisulfotetramine || isoborneol || 13-desmethylspirolide C |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.8501 | INHERITED FROM: carvone || Pregnanolone || Rocuronium || Bridged-Ring Compounds || 13,19-didesmethyl spirolide C || beta-thujone || menthone || N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline || Vecuronium Bromide || Picrotoxin || Pancuronium || Camphor || tetramethylenedisulfotetramine || isoborneol || 13-desmethylspirolide C |
| Actin-like ATPase domain | 0.8637 | INHERITED FROM: aurin || bufalin || Hemin || Ivermectin || Thiostrepton || yessotoxin |
| Prefoldin | 0.88 | INHERITED FROM: ethyl-p-((E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-1-propenyl)benzoic acid || Bexarotene || beta Carotene || 4-oxoretinoic acid || Alitretinoin || 4-oxoretinol |
| BPTI-like | 0.9 | INHERITED FROM: Paclitaxel || Taxoids || Cyclodecanes |
| TNF-like | 0.9155 | INHERITED FROM: aloe emodin || Menthol || Lovastatin || Cyclohexanols || Medroxyprogesterone Acetate || Plicamycin || brevetoxin 2 || Cyclohexane Monoterpenes || Hydroxyprogesterones |
| Cytokine | 0.9308 | INHERITED FROM: Anthracenes || Cholesterol || Simvastatin || 1-nitropyrene || Lovastatin || Beclomethasone || Suramin || Naphthalenesulfonates || Steroids, Chlorinated |
| Insulin-like | 0.9336 | INHERITED FROM: Norgestrel || Wortmannin || Androstenols || Androstenes || Androstanes || Testosterone || Norsteroids || Hydrocortisone |
| TK C-terminal domain-like | 0.9363 | INHERITED FROM: Isotretinoin |
| Cadherin-like | 0.9402 | INHERITED FROM: jasplakinolide || dibenzo(a,l)pyrene |
| Fibrinogen C-terminal domain-like | 0.9428 | INHERITED FROM: ethinyl estradiol-desogestrel combination || dienogest || estradiol valerate-dienogest || norgestimate || Norethindrone || Progesterone || Desogestrel || azaspiracid || Gestodene || Nandrolone |
| Chaperone J-domain | 0.9538 | INHERITED FROM: Carbaryl || motexafin gadolinium |
| Thiamin diphosphate-binding fold (THDP-binding) | 0.9724 | INHERITED FROM: Isotretinoin |
| Immunoglobulin | 0.9765 | INHERITED FROM: 24,25-epoxycholesterol || helenalin || 5H-benzo(4,5)cyclohepta(1,2-b)pyridin-5-one |
| Intermediate filament protein, coiled coil region | 0.9942 | INHERITED FROM: ethyl-p-((E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-1-propenyl)benzoic acid || Microcystins || calcipotriene || beta Carotene || 4-oxoretinoic acid || Alitretinoin || Isotretinoin || 4-oxoretinol |
| 4-helical cytokines | 0.9951 | INHERITED FROM: apocarotenal || Betamethasone || Dehydroepiandrosterone || Polyketides || Anthracenes || Dactinomycin || Prednisolone || helenalin || Cyclohexanecarboxylic Acids || Spironolactone || Cholesterol || Phytosterols || Simvastatin || deoxynivalenol || Mifepristone || Androstadienes || Lovastatin || Morphinans || Tetrapyrroles || Norbornanes || Withanolides || Androstenes || Androstanes || Methylprednisolone || Medroxyprogesterone || Epirubicin || primycin || Camphanes || Budesonide || Beclomethasone || Medroxyprogesterone Acetate || Dydrogesterone || Dibenzocycloheptenes || Benzocycloheptenes || Pregnenes || Cilomilast || Cholestenones || Clarithromycin || Pregnenediones || alclometasone dipropionate || Oxocins || brevetoxin 2 || Hydrocortisone || FEC protocol || Betamethasone Valerate || Pregnadienediols || Alitretinoin || SR 144528 || Ergosterol || Trichothecenes || Phenanthrenes || paricalcitol || Steroids, Chlorinated || coagulin-L || Ethers, Cyclic |
| HLH, helix-loop-helix DNA-binding domain | 1 | INHERITED FROM: eldecalcitol || dihydroxy-vitamin D3 || Dihydrotestosterone || azaspiracid || testosterone-3-carboxymethyloxime-bovine serum albumin conjugate || Rifampin |
| Family A G protein-coupled receptor-like | 1 | INHERITED FROM: 8-Hydroxy-2-(di-n-propylamino)tetralin || Rocuronium || 2-(beta-(3-iodo-4-hydroxyphenyl)ethylaminomethyl)tetralone || methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate || oleandrin || Sapogenins || Spiperone || Pancuronium || Oleanolic Acid |
| Trypsin-like serine proteases | 1 | INHERITED FROM: ethinyl estradiol-desogestrel combination || Azasteroids || NuvaRing || estradiol valerate-dienogest || norgestimate || Medroxyprogesterone || Medroxyprogesterone Acetate || estradiol, norethindrone drug combination || Norethindrone || Dutasteride || Norpregnatrienes || Gestodene || Nandrolone |
| Homeodomain-like | 1 | INHERITED FROM: apocarotenal || beta Carotene |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| VPS9 domain | 0 | Direct |
| Integrin domains | 0 | Direct |
| 3-carboxy-cis,cis-mucoante lactonizing enzyme | 0 | Direct |
| AXH domain | 0 | Direct |
| Amine oxidase catalytic domain | 0 | Direct |
| GINS helical bundle-like | 0 | Direct |
| Peptidylarginine deiminase Pad4, middle domain | 0 | Direct |
| MIR domain | 0 | Direct |
| LeuD/IlvD-like | 0 | Direct |
| PurM C-terminal domain-like | 0 | Direct |
| Leukotriene A4 hydrolase N-terminal domain | 0 | Direct |
| Ribonuclease PH domain 2-like | 0 | Direct |
| LanC-like | 0 | Direct |
| TB module/8-cys domain | 0 | Direct |
| USP8 N-terminal domain-like | 0 | Direct |
| Class I glutamine amidotransferase-like | 0 | Direct |
| A heparin-binding domain | 0 | Direct |
| I/LWEQ domain | 0 | Direct |
| 4Fe-4S ferredoxins | 0 | Direct |
| Translation proteins SH3-like domain | 0 | Direct |
| Metallothionein | 0 | Direct |
| ValRS/IleRS/LeuRS editing domain | 0 | Direct |
| Thiolase-like | 0 | Direct |
| PEBP-like | 0 | Direct |
| FMT C-terminal domain-like | 0 | Direct |
| Putative isomerase YbhE | 0 | Direct |
| Zn-finger domain of Sec23/24 | 0 | Direct |
| Transcription factor STAT-4 N-domain | 0 | Direct |
| CCHHC domain | 0 | Direct |
| Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain | 0 | Direct |
| WW domain | 0 | Direct |
| Apolipoprotein A-I | 0 | Direct |
| Sema domain | 0 | Direct |
| Formate/glycerate dehydrogenase catalytic domain-like | 0 | Direct |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
| Release factor | 0 | Direct |
| Phosphoglycerate mutase-like | 0 | Direct |
| YWTD domain | 0 | Direct |
| AN1-like Zinc finger | 0 | Direct |
| Periplasmic binding protein-like II | 0 | Direct |
| Gamma-glutamyl cyclotransferase-like | 0 | Direct |
| FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
| Integrin beta tail domain | 0 | Direct |
| His-Me finger endonucleases | 0 | Direct |
| Activating enzymes of the ubiquitin-like proteins | 0 | Direct |
| Glutamine synthetase/guanido kinase | 0 | Direct |
| occludin/ELL-like | 0 | Direct |
| alpha-catenin/vinculin-like | 0 | Direct |
| Adenine nucleotide alpha hydrolases-like | 0 | Direct |
| Actin-crosslinking proteins | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| BTG domain-like | 0 | Direct |
| Tryptophan synthase beta subunit-like PLP-dependent enzymes | 0 | Direct |
| Terpenoid cyclases/Protein prenyltransferases | 0 | Direct |
| Domain of poly(ADP-ribose) polymerase | 0 | Direct |
| Six-hairpin glycosidases | 0 | Direct |
| PLP-binding barrel | 0 | Direct |
| P-domain of calnexin/calreticulin | 0 | Direct |
| PriA/YqbF domain | 0 | Direct |
| Pentein | 0 | Direct |
| DLC | 0 | Direct |
| PRTase-like | 0 | Direct |
| Mss4-like | 0 | Direct |
| Amine oxidase N-terminal region | 0 | Direct |
| N-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Creatinase/prolidase N-terminal domain | 0 | Direct |
| HIT-like | 0 | Direct |
| Fe-S cluster assembly (FSCA) domain-like | 0 | Direct |
| Phosphofructokinase | 0 | Direct |
| L-aspartase-like | 0 | Direct |
| Clathrin adaptor appendage domain | 0 | Direct |
| STAT | 0 | Direct |
| AlbA-like | 0 | Direct |
| Families 57/38 glycoside transferase middle domain | 0 | Direct |
| Proteasome activator | 0 | Direct |
| Nucleotidylyl transferase | 0 | Direct |
| Stathmin | 0 | Direct |
| Thyroglobulin type-1 domain | 0 | Direct |
| Aminoacid dehydrogenase-like, N-terminal domain | 0 | Direct |
| AraD/HMP-PK domain-like | 0 | Direct |
| BolA-like | 0 | Direct |
| PurM N-terminal domain-like | 0 | Direct |
| Uracil-DNA glycosylase-like | 0 | Direct |
| Eferin C-derminal domain-like | 0 | Direct |
| Galactose mutarotase-like | 0 | Direct |
| Endosomal sorting complex assembly domain | 0 | Direct |
| 5' to 3' exonuclease, C-terminal subdomain | 0 | Direct |
| Lipoxigenase | 0 | Direct |
| C-terminal domain of adenylylcyclase associated protein | 0 | Direct |
| Anaphylotoxins (complement system) | 0 | Direct |
| Subtilisin-like | 0 | Direct |
| Ribosomal protein L30p/L7e | 0 | Direct |
| Aconitase iron-sulfur domain | 0 | Direct |
| RGC domain-like | 0 | Direct |
| GAT-like domain | 0 | Direct |
| SPOC domain-like | 0 | Direct |
| ABC transporter transmembrane region | 0 | Direct |
| RmlC-like cupins | 0 | Direct |
| L27 domain | 0 | Direct |
| EB1 dimerisation domain-like | 0 | Direct |
| FMN-binding split barrel | 0 | Direct |
| Nucleoplasmin-like core domain | 0 | Direct |
| ACT-like | 0 | Direct |
| PK beta-barrel domain-like | 0 | Direct |
| KA1-like | 0 | Direct |
| Delta-sleep-inducing peptide immunoreactive peptide | 0 | Direct |
| Serine protease inhibitors | 0 | Direct |
| PWI domain | 0 | Direct |
| N-terminal domain of cbl (N-cbl) | 0 | Direct |
| DNA-binding domain | 0 | Direct |
| S13-like H2TH domain | 0 | Direct |
| Mediator hinge subcomplex-like | 0 | Direct |
| Homocysteine S-methyltransferase | 0 | Direct |
| Plexin repeat | 0 | Direct |
| BRCT domain | 0 | Direct |
| Alpha-macroglobulin receptor domain | 0 | Direct |
| Nicotinate/Quinolinate PRTase C-terminal domain-like | 0 | Direct |
| Rudiment single hybrid motif | 0 | Direct |
| LCCL domain | 0 | Direct |
| Indolic compounds 2,3-dioxygenase-like | 0 | Direct |
| Heme-dependent peroxidases | 0 | Direct |
| PUG domain-like | 0 | Direct |
| PIN domain-like | 0 | Direct |
| DNA polymerase beta, N-terminal domain-like | 0 | Direct |
| SGNH hydrolase | 0 | Direct |
| Carbon-nitrogen hydrolase | 0 | Direct |
| Carbohydrate phosphatase | 0 | Direct |
| S15/NS1 RNA-binding domain | 0 | Direct |
| Amidase signature (AS) enzymes | 0 | Direct |
| EPT/RTPC-like | 0 | Direct |
| Transferrin receptor-like dimerisation domain | 0 | Direct |
| Serum albumin-like | 0 | Direct |
| CAPPD, an extracellular domain of amyloid beta A4 protein | 0 | Direct |
| Transcription factor IIA (TFIIA), beta-barrel domain | 0 | Direct |
| ADP-ribosylglycohydrolase | 0 | Direct |
| Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
| Cytochrome b5-like heme/steroid binding domain | 0 | Direct |
| BAG domain | 0 | Direct |
| Peptidase/esterase 'gauge' domain | 0 | Direct |
| Mib/herc2 domain-like | 0 | Direct |
| Helical domain of Sec23/24 | 0 | Direct |
| AhpD-like | 0 | Direct |
| Oxysterol-binding protein-like | 0 | Direct |
| WGR domain-like | 0 | Direct |
| Probable bacterial effector-binding domain | 0 | Direct |
| C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
| Single hybrid motif | 0 | Direct |
| Transcription factor IIA (TFIIA), alpha-helical domain | 0 | Direct |
| Notch domain | 0 | Direct |
| Assembly domain of cartilage oligomeric matrix protein | 0 | Direct |
| Hermes dimerisation domain | 0 | Direct |
| MAPEG domain-like | 0 | Direct |
| Clc chloride channel | 0 | Direct |
| Nucleotide-binding domain | 0 | Direct |
| Nop domain | 0 | Direct |
| MOSC N-terminal domain-like | 0 | Direct |
| TAFH domain-like | 0 | Direct |
| ClpS-like | 0 | Direct |
| PAZ domain | 0 | Direct |
| Nucleoporin domain | 0 | Direct |
| DHS-like NAD/FAD-binding domain | 0 | Direct |
| FAD-linked oxidases, C-terminal domain | 0 | Direct |
| beta-lactamase/transpeptidase-like | 0 | Direct |
| FAD-dependent thiol oxidase | 0 | Direct |
| R3H domain | 0 | Direct |
| Cu,Zn superoxide dismutase-like | 0 | Direct |
| ISP domain | 0 | Direct |
| FAD-linked reductases, C-terminal domain | 0 | Direct |
| Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
| Ribosomal protein L16p/L10e | 0 | Direct |
| FF domain | 0 | Direct |
| IP3 receptor type 1 binding core, domain 2 | 0 | Direct |
| Cysteine alpha-hairpin motif | 0 | Direct |
| PAH2 domain | 0 | Direct |
| MgtE membrane domain-like | 0 | Direct |
| Connexin43 | 0 | Direct |
| HR1 repeat | 0 | Direct |
| Alanine racemase C-terminal domain-like | 0 | Direct |
| Alpha-L RNA-binding motif | 0 | Direct |
| Aminomethyltransferase beta-barrel domain | 0 | Direct |
| Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
| Methylglyoxal synthase-like | 0 | Direct |
| Inosine monophosphate dehydrogenase (IMPDH) | 0 | Direct |
| N-(deoxy)ribosyltransferase-like | 0 | Direct |
| Microbial and mitochondrial ADK, insert "zinc finger" domain | 0 | Direct |
| FAD-binding/transporter-associated domain-like | 0 | Direct |
| 2Fe-2S ferredoxin-like | 0 | Direct |
| ITPase-like | 0 | Direct |
| Arginase/deacetylase | 0 | Direct |
| DNA-glycosylase | 0 | Direct |
| Protein prenylyltransferase | 0 | Direct |
| RBP11-like subunits of RNA polymerase | 0 | Direct |
| MAST3 pre-PK domain-like | 0 | Direct |
| Phosphoglucomutase, C-terminal domain | 0 | Direct |
| SIS domain | 0 | Direct |
| Ribosomal protein S18 | 0 | Direct |
| Amyloid beta a4 protein copper binding domain (domain 2) | 0 | Direct |
| alpha/beta knot | 0 | Direct |
| Ribosomal proteins S24e, L23 and L15e | 0 | Direct |
| TIMP-like | 0 | Direct |
| Phosphoglucomutase, first 3 domains | 0 | Direct |
| LysM domain | 0 | Direct |
| Small-conductance potassium channel | 0 | Direct |
| PapD-like | 0 | Direct |
| Nitric oxide (NO) synthase oxygenase domain | 0 | Direct |
| GHMP Kinase, C-terminal domain | 0 | Direct |
| Purine and uridine phosphorylases | 0 | Direct |
| Oncogene products | 0 | Direct |
| JAB1/MPN domain | 0 | Direct |
| Translational machinery components | 0 | Direct |
| G protein-binding domain | 0 | Direct |
| VHP, Villin headpiece domain | 0 | Direct |
| Mannose 6-phosphate receptor domain | 0 | Direct |
| DEK C-terminal domain | 0 | Direct |
| RNase III domain-like | 0 | Direct |
| Rhodanese/Cell cycle control phosphatase | 0 | Direct |
| Acyl-CoA dehydrogenase NM domain-like | 0 | Direct |
| FAD-linked oxidoreductase | 0 | Direct |
| Succinyl-CoA synthetase domains | 0 | Direct |
| Glycolipid transfer protein, GLTP | 0 | Direct |
| PHM/PNGase F | 0 | Direct |
| MIT domain | 0 | Direct |
| p53 tetramerization domain | 0 | Direct |
| 14-3-3 protein | 0 | Direct |
| Seven-hairpin glycosidases | 0 | Direct |
| Calcium-dependent phosphotriesterase | 0 | Direct |
| ATP-dependent DNA ligase DNA-binding domain | 0 | Direct |
| F1F0 ATP synthase subunit C | 0 | Direct |
| Di-copper centre-containing domain | 0 | Direct |
| HSP40/DnaJ peptide-binding domain | 0 | Direct |
| GYF domain | 0 | Direct |
| Proton glutamate symport protein | 0 | Direct |
| Class II aaRS ABD-related | 0 | Direct |
| Ribosomal protein L1 | 0 | Direct |
| Guanido kinase N-terminal domain | 0 | Direct |
| SCP-like | 0 | Direct |
| beta-sandwich domain of Sec23/24 | 0 | Direct |
| beta and beta-prime subunits of DNA dependent RNA-polymerase | 0 | Direct |
| Cation efflux protein transmembrane domain-like | 0 | Direct |
| BSD domain-like | 0 | Direct |
| Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 0 | Direct |
| Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain | 0 | Direct |
| DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
| Bcl-2 inhibitors of programmed cell death | 0 | Direct |
| PRC-barrel domain | 0 | Direct |
| Pseudouridine synthase | 0 | Direct |
| Fibrinogen coiled-coil and central regions | 0 | Direct |
| Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | Direct |
| Ribosomal protein S10 | 0 | Direct |
| FKBP-like | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Hect, E3 ligase catalytic domain | 0 | Direct |
| alpha-ketoacid dehydrogenase kinase, N-terminal domain | 0 | Direct |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
| Trimeric LpxA-like enzymes | 0 | Direct |
| Formyltransferase | 0 | Direct |
| Sec7 domain | 0 | Direct |
| GFP-like | 0 | Direct |
| Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain | 0 | Direct |
| C-terminal domain of PLC-beta | 0 | Direct |
| Chicken cartilage matrix protein | 0 | Direct |
| Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
| BRK domain-like | 0 | Direct |
| BEACH domain | 0 | Direct |
| Restriction endonuclease-like | 0 | Direct |
| Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | Direct |
| FMN-linked oxidoreductases | 0 | Direct |
| Troponin coil-coiled subunits | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| Phosphoenolpyruvate/pyruvate domain | 0 | Direct |
| GTF2I-like repeat | 0 | Direct |
| DUSP-like | 0 | Direct |
| Mitochondrial cytochrome c oxidase subunit VIIa | 0 | Direct |
| PABC (PABP) domain | 0 | Direct |
| Cation efflux protein cytoplasmic domain-like | 0 | Direct |
| CAD & PB1 domains | 0 | Direct |
| Ribosomal L27 protein-like | 0 | Direct |
| TSP type-3 repeat | 0 | Direct |
| ARID-like | 0 | Direct |
| YVTN repeat-like/Quinoprotein amine dehydrogenase | 0 | Direct |
| Glycoside hydrolase/deacetylase | 0 | Direct |
| Bacterial exopeptidase dimerisation domain | 0 | Direct |
| DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
| ALDH-like | 0 | Direct |
| P-loop containing nucleoside triphosphate hydrolases | 0.00000003465 | Direct |
| ARM repeat | 0.000000103 | Direct |
| PH domain-like | 0.000002367 | Direct |
| SH3-domain | 0.000004917 | Direct |
| EGF/Laminin | 0.00004166 | Direct |
| FYVE/PHD zinc finger | 0.000248 | Direct |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.0003334 | Direct |
| Cytochrome P450 | 0.001103 | Inherited |
| FAD/NAD(P)-binding domain | 0.001648 | Inherited |
| Protein kinase-like (PK-like) | 0.001684 | Inherited |
| PDZ domain-like | 0.001722 | Inherited |
| Growth factor receptor domain | 0.001937 | Inherited |
| Nuclear receptor ligand-binding domain | 0.004168 | Inherited |
| TSP-1 type 1 repeat | 0.005093 | Inherited |
| Ubiquitin-like | 0.005143 | Inherited |
| GTPase activation domain, GAP | 0.005325 | Inherited |
| Metalloproteases ("zincins"), catalytic domain | 0.006739 | Inherited |
| Interleukin 8-like chemokines | 0.007014 | Inherited |
| Bromodomain | 0.009052 | Inherited |
| GST C-terminal domain-like | 0.01327 | Inherited |
| SH2 domain | 0.01897 | Inherited |
| NAD(P)-binding Rossmann-fold domains | 0.02012 | Inherited |
| Second domain of FERM | 0.02457 | Inherited |
| PYP-like sensor domain (PAS domain) | 0.02786 | Inherited |
| Calponin-homology domain, CH-domain | 0.02984 | Inherited |
| Alkaline phosphatase-like | 0.03551 | Inherited |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 0.03616 | Inherited |
| Ras GEF | 0.04001 | Inherited |
| Mitochondrial carrier | 0.05749 | Inherited |
| Fibronectin type III | 0.05852 | Inherited |
| Galactose-binding domain-like | 0.05899 | Inherited |
| SNARE fusion complex | 0.06418 | Inherited |
| HD-domain/PDEase-like | 0.07202 | Inherited |
| TNF receptor-like | 0.08083 | Inherited |
| ADP-ribosylation | 0.08083 | Inherited |
| Cysteine-rich domain | 0.08864 | Inherited |
| Integrin alpha N-terminal domain | 0.09058 | Inherited |
| Hemopexin-like domain | 0.09058 | Inherited |
| N-terminal nucleophile aminohydrolases (Ntn hydrolases) | 0.1007 | Inherited |
| Sm-like ribonucleoproteins | 0.1014 | Inherited |
| Ran binding protein zinc finger-like | 0.1014 | Inherited |
| Ribosomal protein S5 domain 2-like | 0.1108 | Inherited |
| Metal cation-transporting ATPase, ATP-binding domain N | 0.1108 | Inherited |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0.1137 | Inherited |
| GroES-like | 0.1137 | Inherited |
| UDP-Glycosyltransferase/glycogen phosphorylase | 0.1144 | Inherited |
| Frizzled cysteine-rich domain | 0.127 | Inherited |
| Nucleic acid-binding proteins | 0.1296 | Inherited |
| FnI-like domain | 0.133 | Inherited |
| SNF-like | 0.1417 | Inherited |
| PGBD-like | 0.1417 | Inherited |
| Cupredoxins | 0.1417 | Inherited |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0.1417 | Inherited |
| Riboflavin synthase domain-like | 0.1417 | Inherited |
| RNA-binding domain, RBD | 0.1489 | Inherited |
| Leucine zipper domain | 0.1494 | Inherited |
| SMAD/FHA domain | 0.1494 | Inherited |
| Cyclin-like | 0.1572 | Inherited |
| PLP-dependent transferases | 0.1572 | Inherited |
| Thioredoxin-like | 0.1582 | Inherited |
| DBL homology domain (DH-domain) | 0.1761 | Inherited |
| SNARE-like | 0.1895 | Inherited |
| DEATH domain | 0.1919 | Inherited |
| Histone-fold | 0.1922 | Inherited |
| DNA/RNA polymerases | 0.1969 | Inherited |
| Periplasmic binding protein-like I | 0.1977 | Inherited |
| vWA-like | 0.2026 | Inherited |
| Calcium ATPase, transmembrane domain M | 0.2132 | Inherited |
| L30e-like | 0.2199 | Inherited |
| Caspase-like | 0.2199 | Inherited |
| (Phosphotyrosine protein) phosphatases II | 0.2218 | Inherited |
| Kringle-like | 0.225 | Inherited |
| Toll/Interleukin receptor TIR domain | 0.225 | Inherited |
| Calcium ATPase, transduction domain A | 0.2292 | Inherited |
| Serpins | 0.2292 | Inherited |
| GLA-domain | 0.2441 | Inherited |
| Class II aaRS and biotin synthetases | 0.2445 | Inherited |
| Tubulin nucleotide-binding domain-like | 0.2665 | Inherited |
| Calpain large subunit, middle domain (domain III) | 0.2723 | Inherited |
| p53-like transcription factors | 0.2735 | Inherited |
| E set domains | 0.2833 | Inherited |
| Tubulin C-terminal domain-like | 0.2883 | Inherited |
| TRAF domain-like | 0.2883 | Inherited |
| Aldolase | 0.3021 | Inherited |
| Cystine-knot cytokines | 0.303 | Inherited |
| MFS general substrate transporter | 0.322 | Inherited |
| CoA-dependent acyltransferases | 0.3353 | Inherited |
| Rap/Ran-GAP | 0.3353 | Inherited |
| TPR-like | 0.343 | Inherited |
| Acetyl-CoA synthetase-like | 0.3466 | Inherited |
| Nucleotidyltransferase | 0.3652 | Inherited |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.3717 | Inherited |
| Zn-binding ribosomal proteins | 0.3717 | Inherited |
| Orange domain-like | 0.3717 | Inherited |
| Tropomyosin | 0.3934 | Inherited |
| Glycerol-3-phosphate (1)-acyltransferase | 0.3934 | Inherited |
| LDL receptor-like module | 0.4212 | Inherited |
| Cyclophilin-like | 0.4244 | Inherited |
| NAD(P)-linked oxidoreductase | 0.457 | Inherited |
| A DNA-binding domain in eukaryotic transcription factors | 0.4895 | Inherited |
| SAP domain | 0.5004 | Inherited |
| Ferritin-like | 0.5065 | Inherited |
| Plakin repeat | 0.5065 | Inherited |
| LuxS/MPP-like metallohydrolase | 0.5065 | Inherited |
| (Trans)glycosidases | 0.5459 | Inherited |
| Polo-box domain | 0.5632 | Inherited |
| GroEL apical domain-like | 0.5643 | Inherited |
| PAP/OAS1 substrate-binding domain | 0.5643 | Inherited |
| GroEL equatorial domain-like | 0.5643 | Inherited |
| MHC antigen-recognition domain | 0.5779 | Inherited |
| HMA, heavy metal-associated domain | 0.6241 | Inherited |
| Multidrug efflux transporter AcrB transmembrane domain | 0.6444 | Inherited |
| GroEL-intermediate domain like | 0.6444 | Inherited |
| "Winged helix" DNA-binding domain | 0.6667 | Inherited |
| Nucleoside diphosphate kinase, NDK | 0.6866 | Inherited |
| alpha/beta-Hydrolases | 0.691 | Inherited |
| CCCH zinc finger | 0.723 | Inherited |
| EF-hand | 0.7278 | Inherited |
| Flavoproteins | 0.7286 | Inherited |
| Lipocalins | 0.7466 | Inherited |
| ClpP/crotonase | 0.7493 | Inherited |
| Translation proteins | 0.7704 | Inherited |
| E2F-DP heterodimerization region | 0.7716 | Inherited |
| Kazal-type serine protease inhibitors | 0.8012 | Inherited |
| Voltage-gated potassium channels | 0.8487 | Inherited |
| Nicotinic receptor ligand binding domain-like | 0.8501 | Inherited |
| Neurotransmitter-gated ion-channel transmembrane pore | 0.8501 | Inherited |
| Actin-like ATPase domain | 0.8637 | Inherited |
| Prefoldin | 0.88 | Inherited |
| BPTI-like | 0.9 | Inherited |
| TNF-like | 0.9155 | Inherited |
| Cytokine | 0.9308 | Inherited |
| Insulin-like | 0.9336 | Inherited |
| TK C-terminal domain-like | 0.9363 | Inherited |
| Cadherin-like | 0.9402 | Inherited |
| Fibrinogen C-terminal domain-like | 0.9428 | Inherited |
| Chaperone J-domain | 0.9538 | Inherited |
| Thiamin diphosphate-binding fold (THDP-binding) | 0.9724 | Inherited |
| Immunoglobulin | 0.9765 | Inherited |
| Intermediate filament protein, coiled coil region | 0.9942 | Inherited |
| 4-helical cytokines | 0.9951 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 1 | Inherited |
| Family A G protein-coupled receptor-like | 1 | Inherited |
| Trypsin-like serine proteases | 1 | Inherited |
| Homeodomain-like | 1 | Inherited |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
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Supra-domain (Duplex) in N- to C-terminal order( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57850,52540
57850 - RING/U-box
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
56112,64268
56112 - Protein kinase-like (PK-like)
64268 - PX domain | 0 | DIRECT |
54637,54637
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | DIRECT |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0 | DIRECT |
57889,48350
57889 - Cysteine-rich domain
48350 - GTPase activation domain, GAP | 0 | DIRECT |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0 | DIRECT |
48452,46785
48452 - TPR-like
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
49410,50242
49410 - Alpha-macroglobulin receptor domain
50242 - TIMP-like | 0 | DIRECT |
50993,53474
50993 - Peptidase/esterase 'gauge' domain
53474 - alpha/beta-Hydrolases | 0 | DIRECT |
48726,56436
48726 - Immunoglobulin
56436 - C-type lectin-like | 0 | DIRECT |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0 | DIRECT |
53300,49265
53300 - vWA-like
49265 - Fibronectin type III | 0 | DIRECT |
52047,48371
52047 - RNI-like
48371 - ARM repeat | 0 | DIRECT |
103575,81296
103575 - Plexin repeat
81296 - E set domains | 0 | DIRECT |
50044,48065
50044 - SH3-domain
48065 - DBL homology domain (DH-domain) | 0 | DIRECT |
53223,51735
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
54791,54791
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | DIRECT |
63763,57903
63763 - SAND domain-like
57903 - FYVE/PHD zinc finger | 0 | DIRECT |
57889,49562
57889 - Cysteine-rich domain
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
82199,57903
82199 - SET domain
57903 - FYVE/PHD zinc finger | 0 | DIRECT |
47370,47370
47370 - Bromodomain
47370 - Bromodomain | 0 | DIRECT |
100895,50494
100895 - Kazal-type serine protease inhibitors
50494 - Trypsin-like serine proteases | 0 | DIRECT |
56024,56024
56024 - Phospholipase D/nuclease
56024 - Phospholipase D/nuclease | 0 | DIRECT |
100895,47473
100895 - Kazal-type serine protease inhibitors
47473 - EF-hand | 0 | DIRECT |
53822,53850
53822 - Periplasmic binding protein-like I
53850 - Periplasmic binding protein-like II | 0 | DIRECT |
48425,50729
48425 - Sec7 domain
50729 - PH domain-like | 0 | DIRECT |
56176,55103
56176 - FAD-binding/transporter-associated domain-like
55103 - FAD-linked oxidases, C-terminal domain | 0 | DIRECT |
47353,109640
47353 - Retrovirus capsid dimerization domain-like
109640 - KRAB domain (Kruppel-associated box) | 0 | DIRECT |
81995,81811
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24 | 0 | DIRECT |
49562,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain | 0 | DIRECT |
57756,57756
57756 - Retrovirus zinc finger-like domains
57756 - Retrovirus zinc finger-like domains | 0 | DIRECT |
47473,57850
47473 - EF-hand
57850 - RING/U-box | 0 | DIRECT |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | DIRECT |
54534,47473
54534 - FKBP-like
47473 - EF-hand | 0 | DIRECT |
49854,57196
49854 - Spermadhesin, CUB domain
57196 - EGF/Laminin | 0 | DIRECT |
57184,49854
57184 - Growth factor receptor domain
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
53300,69318
53300 - vWA-like
69318 - Integrin alpha N-terminal domain | 0 | DIRECT |
63501,50242
63501 - Frizzled cysteine-rich domain
50242 - TIMP-like | 0 | DIRECT |
54768,-9
54768 - dsRNA-binding domain-like
-9 - PDB | 0 | DIRECT |
57362,57362
57362 - BPTI-like
57362 - BPTI-like | 0 | DIRECT |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
47576,48065
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain) | 0 | DIRECT |
48726,56112
48726 - Immunoglobulin
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
52949,52949
52949 - Macro domain-like
52949 - Macro domain-like | 0 | DIRECT |
57184,100895
57184 - Growth factor receptor domain
100895 - Kazal-type serine protease inhibitors | 0 | DIRECT |
48726,82895
48726 - Immunoglobulin
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0 | DIRECT |
-8,54980
-8 - ECOD
54980 - EF-G C-terminal domain-like | 0 | DIRECT |
48350,55961
48350 - GTPase activation domain, GAP
55961 - Bet v1-like | 0 | DIRECT |
54928,90209
54928 - RNA-binding domain, RBD
90209 - Ran binding protein zinc finger-like | 0 | DIRECT |
57424,49899
57424 - LDL receptor-like module
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
48371,46785
48371 - ARM repeat
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
51206,51206
51206 - cAMP-binding domain-like
51206 - cAMP-binding domain-like | 0 | DIRECT |
82754,55753
82754 - C-terminal, gelsolin-like domain of Sec23/24
55753 - Actin depolymerizing proteins | 0 | DIRECT |
53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | DIRECT |
57196,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
100895,48726
100895 - Kazal-type serine protease inhibitors
48726 - Immunoglobulin | 0 | DIRECT |
81811,82754
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
64268,49562
64268 - PX domain
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
52283,51735
52283 - Formate/glycerate dehydrogenase catalytic domain-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
57424,57196
57424 - LDL receptor-like module
57196 - EGF/Laminin | 0 | DIRECT |
57581,57196
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0 | DIRECT |
57863,50729
57863 - ArfGap/RecO-like zinc finger
50729 - PH domain-like | 0 | DIRECT |
47203,47203
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
47676,46942
47676 - Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
46942 - Elongation factor TFIIS domain 2 | 0 | DIRECT |
53187,55031
53187 - Zn-dependent exopeptidases
55031 - Bacterial exopeptidase dimerisation domain | 0 | DIRECT |
63737,55486
63737 - Leukotriene A4 hydrolase N-terminal domain
55486 - Metalloproteases ("zincins"), catalytic domain | 0 | DIRECT |
49503,110083
49503 - Cupredoxins
110083 - Peptidylarginine deiminase Pad4, middle domain | 0 | DIRECT |
51905,55424
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | DIRECT |
117839,56399
117839 - WWE domain
56399 - ADP-ribosylation | 0 | DIRECT |
57196,49854
57196 - EGF/Laminin
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
47473,103506
47473 - EF-hand
103506 - Mitochondrial carrier | 0 | DIRECT |
55326,56042
55326 - PurM N-terminal domain-like
56042 - PurM C-terminal domain-like | 0 | DIRECT |
48371,101447
48371 - ARM repeat
101447 - Formin homology 2 domain (FH2 domain) | 0 | DIRECT |
57196,69687
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0 | DIRECT |
52025,53187
52025 - PA domain
53187 - Zn-dependent exopeptidases | 0 | DIRECT |
57938,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
47113,-7
47113 - Histone-fold
-7 - CATH | 0 | DIRECT |
52540,48340
52540 - P-loop containing nucleoside triphosphate hydrolases
48340 - Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain | 0 | DIRECT |
54236,57889
54236 - Ubiquitin-like
57889 - Cysteine-rich domain | 0 | DIRECT |
57196,50494
57196 - EGF/Laminin
50494 - Trypsin-like serine proteases | 0 | DIRECT |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | DIRECT |
50494,50156
50494 - Trypsin-like serine proteases
50156 - PDZ domain-like | 0 | DIRECT |
57492,74650
57492 - Trefoil
74650 - Galactose mutarotase-like | 0 | DIRECT |
57196,49265
57196 - EGF/Laminin
49265 - Fibronectin type III | 0 | DIRECT |
69572,69572
69572 - Activating enzymes of the ubiquitin-like proteins
69572 - Activating enzymes of the ubiquitin-like proteins | 0 | DIRECT |
49599,49599
49599 - TRAF domain-like
49599 - TRAF domain-like | 0 | DIRECT |
56801,56801
56801 - Acetyl-CoA synthetase-like
56801 - Acetyl-CoA synthetase-like | 0 | DIRECT |
54695,54695
54695 - POZ domain
54695 - POZ domain | 0 | DIRECT |
103575,48726
103575 - Plexin repeat
48726 - Immunoglobulin | 0 | DIRECT |
81324,53850
81324 - Voltage-gated potassium channels
53850 - Periplasmic binding protein-like II | 0 | DIRECT |
90188,53649
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like | 0 | DIRECT |
46966,51045
46966 - Spectrin repeat
51045 - WW domain | 0 | DIRECT |
54160,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
48403,50044
48403 - Ankyrin repeat
50044 - SH3-domain | 0 | DIRECT |
81837,50978
81837 - BEACH domain
50978 - WD40 repeat-like | 0 | DIRECT |
47060,55681
47060 - S15/NS1 RNA-binding domain
55681 - Class II aaRS and biotin synthetases | 0 | DIRECT |
52540,57774
52540 - P-loop containing nucleoside triphosphate hydrolases
57774 - Microbial and mitochondrial ADK, insert "zinc finger" domain | 0 | DIRECT |
47473,57610
47473 - EF-hand
57610 - Thyroglobulin type-1 domain | 0 | DIRECT |
48403,47986
48403 - Ankyrin repeat
47986 - DEATH domain | 0 | DIRECT |
48371,49348
48371 - ARM repeat
49348 - Clathrin adaptor appendage domain | 0 | DIRECT |
47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | DIRECT |
52821,52799
52821 - Rhodanese/Cell cycle control phosphatase
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
53300,49899
53300 - vWA-like
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
48366,47473
48366 - Ras GEF
47473 - EF-hand | 0 | DIRECT |
74650,51445
74650 - Galactose mutarotase-like
51445 - (Trans)glycosidases | 0 | DIRECT |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | DIRECT |
47986,47986
47986 - DEATH domain
47986 - DEATH domain | 0 | DIRECT |
50370,57440
50370 - Ricin B-like lectins
57440 - Kringle-like | 0 | DIRECT |
81324,81327
81324 - Voltage-gated potassium channels
81327 - Small-conductance potassium channel | 0 | DIRECT |
52980,47781
52980 - Restriction endonuclease-like
47781 - RuvA domain 2-like | 0 | DIRECT |
49695,50370
49695 - gamma-Crystallin-like
50370 - Ricin B-like lectins | 0 | DIRECT |
54211,55666
54211 - Ribosomal protein S5 domain 2-like
55666 - Ribonuclease PH domain 2-like | 0 | DIRECT |
47769,47769
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain | 0 | DIRECT |
49742,49742
49742 - PHM/PNGase F
49742 - PHM/PNGase F | 0 | DIRECT |
63748,57903
63748 - Tudor/PWWP/MBT
57903 - FYVE/PHD zinc finger | 0 | DIRECT |
50044,47769
50044 - SH3-domain
47769 - SAM/Pointed domain | 0 | DIRECT |
50447,-8
50447 - Translation proteins
-8 - ECOD | 0 | DIRECT |
53738,55957
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
53098,56672
53098 - Ribonuclease H-like
56672 - DNA/RNA polymerases | 0 | DIRECT |
54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 0 | DIRECT |
57196,57581
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0 | DIRECT |
55550,57850
55550 - SH2 domain
57850 - RING/U-box | 0 | DIRECT |
57581,57184
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain | 0 | DIRECT |
50978,50998
50978 - WD40 repeat-like
50998 - Quinoprotein alcohol dehydrogenase-like | 0 | DIRECT |
56059,51246
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0 | DIRECT |
56487,56487
56487 - SRCR-like
56487 - SRCR-like | 0 | DIRECT |
54001,143791
54001 - Cysteine proteinases
143791 - DUSP-like | 0 | DIRECT |
55186,55681
55186 - ThrRS/AlaRS common domain
55681 - Class II aaRS and biotin synthetases | 0 | DIRECT |
47661,58038
47661 - t-snare proteins
58038 - SNARE fusion complex | 0 | DIRECT |
48403,52540
48403 - Ankyrin repeat
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
48452,57850
48452 - TPR-like
57850 - RING/U-box | 0 | DIRECT |
46689,57667
46689 - Homeodomain-like
57667 - beta-beta-alpha zinc fingers | 0 | DIRECT |
57184,57581
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain | 0 | DIRECT |
55486,49854
55486 - Metalloproteases ("zincins"), catalytic domain
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
54403,54403
54403 - Cystatin/monellin
54403 - Cystatin/monellin | 0 | DIRECT |
47576,143575
47576 - Calponin-homology domain, CH-domain
143575 - GAS2 domain-like | 0 | DIRECT |
102712,-7
102712 - JAB1/MPN domain
-7 - CATH | 0 | DIRECT |
49899,57424
49899 - Concanavalin A-like lectins/glucanases
57424 - LDL receptor-like module | 0 | DIRECT |
63825,57196
63825 - YWTD domain
57196 - EGF/Laminin | 0 | DIRECT |
52743,49785
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | DIRECT |
54416,49998
54416 - Amine oxidase N-terminal region
49998 - Amine oxidase catalytic domain | 0 | DIRECT |
48464,89009
48464 - ENTH/VHS domain
89009 - GAT-like domain | 0 | DIRECT |
47986,52129
47986 - DEATH domain
52129 - Caspase-like | 0 | DIRECT |
117018,56091
117018 - ATP-dependent DNA ligase DNA-binding domain
56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | DIRECT |
49493,49493
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
57196,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0 | DIRECT |
49785,49785
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like | 0 | DIRECT |
90209,90209
90209 - Ran binding protein zinc finger-like
90209 - Ran binding protein zinc finger-like | 0 | DIRECT |
47862,47862
47862 - Saposin
47862 - Saposin | 0 | DIRECT |
56672,100879
56672 - DNA/RNA polymerases
100879 - Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | DIRECT |
54236,48366
54236 - Ubiquitin-like
48366 - Ras GEF | 0 | DIRECT |
52540,90123
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0 | DIRECT |
90193,90193
90193 - Notch domain
90193 - Notch domain | 0 | DIRECT |
63748,82199
63748 - Tudor/PWWP/MBT
82199 - SET domain | 0 | DIRECT |
81271,55186
81271 - TGS-like
55186 - ThrRS/AlaRS common domain | 0 | DIRECT |
54534,48452
54534 - FKBP-like
48452 - TPR-like | 0 | DIRECT |
53300,53300
53300 - vWA-like
53300 - vWA-like | 0 | DIRECT |
46785,54928
46785 - "Winged helix" DNA-binding domain
54928 - RNA-binding domain, RBD | 0 | DIRECT |
55486,48371
55486 - Metalloproteases ("zincins"), catalytic domain
48371 - ARM repeat | 0 | DIRECT |
55874,54211
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
54211 - Ribosomal protein S5 domain 2-like | 0 | DIRECT |
48371,49899
48371 - ARM repeat
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
69065,54768
69065 - RNase III domain-like
54768 - dsRNA-binding domain-like | 0 | DIRECT |
51445,51445
51445 - (Trans)glycosidases
51445 - (Trans)glycosidases | 0 | DIRECT |
53732,52016
53732 - Aconitase iron-sulfur domain
52016 - LeuD/IlvD-like | 0 | DIRECT |
50044,56112
50044 - SH3-domain
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
50729,48350
50729 - PH domain-like
48350 - GTPase activation domain, GAP | 0 | DIRECT |
46966,47473
46966 - Spectrin repeat
47473 - EF-hand | 0 | DIRECT |
49313,49899
49313 - Cadherin-like
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
53927,53927
53927 - Cytidine deaminase-like
53927 - Cytidine deaminase-like | 0 | DIRECT |
69318,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0 | DIRECT |
102848,54236
102848 - NSFL1 (p97 ATPase) cofactor p47, SEP domain
54236 - Ubiquitin-like | 0 | DIRECT |
48371,-7
48371 - ARM repeat
-7 - CATH | 0 | DIRECT |
52799,52799
52799 - (Phosphotyrosine protein) phosphatases II
52799 - (Phosphotyrosine protein) phosphatases II | 0 | DIRECT |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0 | DIRECT |
51905,54373
51905 - FAD/NAD(P)-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0 | DIRECT |
53784,53784
53784 - Phosphofructokinase
53784 - Phosphofructokinase | 0 | DIRECT |
82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
57184,49899
57184 - Growth factor receptor domain
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | DIRECT |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
54897,52743
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like | 0 | DIRECT |
161111,160240
161111 - Cation efflux protein transmembrane domain-like
160240 - Cation efflux protein cytoplasmic domain-like | 0 | DIRECT |
100920,100934
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
47005,52777
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
52777 - CoA-dependent acyltransferases | 0 | DIRECT |
81698,81698
81698 - FF domain
81698 - FF domain | 0 | DIRECT |
55550,158235
55550 - SH2 domain
158235 - SOCS box-like | 0 | DIRECT |
50156,52540
50156 - PDZ domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
88713,88688
88713 - Glycoside hydrolase/deacetylase
88688 - Families 57/38 glycoside transferase middle domain | 0 | DIRECT |
57535,50494
57535 - Complement control module/SCR domain
50494 - Trypsin-like serine proteases | 0 | DIRECT |
54211,55060
54211 - Ribosomal protein S5 domain 2-like
55060 - GHMP Kinase, C-terminal domain | 0 | DIRECT |
56091,50249
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
47473,57889
47473 - EF-hand
57889 - Cysteine-rich domain | 0 | DIRECT |
53850,53850
53850 - Periplasmic binding protein-like II
53850 - Periplasmic binding protein-like II | 0 | DIRECT |
48350,50729
48350 - GTPase activation domain, GAP
50729 - PH domain-like | 0 | DIRECT |
103025,101790
103025 - Folate-binding domain
101790 - Aminomethyltransferase beta-barrel domain | 0 | DIRECT |
82109,82109
82109 - MIR domain
82109 - MIR domain | 0 | DIRECT |
56645,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
50104,50249
50104 - Translation proteins SH3-like domain
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0 | DIRECT |
50729,57903
50729 - PH domain-like
57903 - FYVE/PHD zinc finger | 0 | DIRECT |
57630,57196
57630 - GLA-domain
57196 - EGF/Laminin | 0 | DIRECT |
53300,81995
53300 - vWA-like
81995 - beta-sandwich domain of Sec23/24 | 0 | DIRECT |
49265,56112
49265 - Fibronectin type III
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
55753,47050
55753 - Actin depolymerizing proteins
47050 - VHP, Villin headpiece domain | 0 | DIRECT |
53187,49464
53187 - Zn-dependent exopeptidases
49464 - Carboxypeptidase regulatory domain-like | 0 | DIRECT |
53300,57184
53300 - vWA-like
57184 - Growth factor receptor domain | 0 | DIRECT |
52540,-7
52540 - P-loop containing nucleoside triphosphate hydrolases
-7 - CATH | 0 | DIRECT |
51045,56204
51045 - WW domain
56204 - Hect, E3 ligase catalytic domain | 0 | DIRECT |
81296,48239
81296 - E set domains
48239 - Terpenoid cyclases/Protein prenyltransferases | 0 | DIRECT |
50729,81837
50729 - PH domain-like
81837 - BEACH domain | 0 | DIRECT |
47576,140612
47576 - Calponin-homology domain, CH-domain
140612 - EB1 dimerisation domain-like | 0 | DIRECT |
51905,47576
51905 - FAD/NAD(P)-binding domain
47576 - Calponin-homology domain, CH-domain | 0 | DIRECT |
74924,74924
74924 - Cap-Gly domain
74924 - Cap-Gly domain | 0 | DIRECT |
52087,48350
52087 - CRAL/TRIO domain
48350 - GTPase activation domain, GAP | 0 | DIRECT |
54236,50729
54236 - Ubiquitin-like
50729 - PH domain-like | 0 | DIRECT |
110324,50249
110324 - Ribosomal L27 protein-like
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
53901,53901
53901 - Thiolase-like
53901 - Thiolase-like | 0 | DIRECT |
100934,100934
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
49265,53300
49265 - Fibronectin type III
53300 - vWA-like | 0 | DIRECT |
54416,54416
54416 - Amine oxidase N-terminal region
54416 - Amine oxidase N-terminal region | 0 | DIRECT |
51045,47473
51045 - WW domain
47473 - EF-hand | 0 | DIRECT |
50129,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
57184,63825
57184 - Growth factor receptor domain
63825 - YWTD domain | 0 | DIRECT |
81901,81901
81901 - HCP-like
81901 - HCP-like | 0 | DIRECT |
57667,90229
57667 - beta-beta-alpha zinc fingers
90229 - CCCH zinc finger | 0 | DIRECT |
48403,56112
48403 - Ankyrin repeat
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
52058,52047
52058 - L domain-like
52047 - RNI-like | 0 | DIRECT |
63748,63748
63748 - Tudor/PWWP/MBT
63748 - Tudor/PWWP/MBT | 0 | DIRECT |
57414,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like | 0 | DIRECT |
49348,55711
49348 - Clathrin adaptor appendage domain
55711 - Subdomain of clathrin and coatomer appendage domain | 0 | DIRECT |
56491,89811
56491 - A heparin-binding domain
89811 - Amyloid beta a4 protein copper binding domain (domain 2) | 0 | DIRECT |
57850,48452
57850 - RING/U-box
48452 - TPR-like | 0 | DIRECT |
64268,56112
64268 - PX domain
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
47587,56399
47587 - Domain of poly(ADP-ribose) polymerase
56399 - ADP-ribosylation | 0 | DIRECT |
50729,46785
50729 - PH domain-like
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
69179,69179
69179 - Integrin domains
69179 - Integrin domains | 0 | DIRECT |
46565,57938
46565 - Chaperone J-domain
57938 - DnaJ/Hsp40 cysteine-rich domain | 0 | DIRECT |
48552,48552
48552 - Serum albumin-like
48552 - Serum albumin-like | 0 | DIRECT |
57535,57196
57535 - Complement control module/SCR domain
57196 - EGF/Laminin | 0 | DIRECT |
56436,57535
56436 - C-type lectin-like
57535 - Complement control module/SCR domain | 0 | DIRECT |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0 | DIRECT |
103657,48350
103657 - BAR/IMD domain-like
48350 - GTPase activation domain, GAP | 0 | DIRECT |
50998,50978
50998 - Quinoprotein alcohol dehydrogenase-like
50978 - WD40 repeat-like | 0 | DIRECT |
101690,53098
101690 - PAZ domain
53098 - Ribonuclease H-like | 0 | DIRECT |
82895,57424
82895 - TSP-1 type 1 repeat
57424 - LDL receptor-like module | 0 | DIRECT |
52113,52113
52113 - BRCT domain
52113 - BRCT domain | 0 | DIRECT |
63380,52343
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | DIRECT |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0 | DIRECT |
49723,48484
49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
48484 - Lipoxigenase | 0 | DIRECT |
46585,46585
46585 - HR1 repeat
46585 - HR1 repeat | 0 | DIRECT |
57903,63748
57903 - FYVE/PHD zinc finger
63748 - Tudor/PWWP/MBT | 0 | DIRECT |
103647,49899
103647 - TSP type-3 repeat
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
57184,82895
57184 - Growth factor receptor domain
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
54277,50156
54277 - CAD & PB1 domains
50156 - PDZ domain-like | 0 | DIRECT |
49265,56496
49265 - Fibronectin type III
56496 - Fibrinogen C-terminal domain-like | 0 | DIRECT |
49899,63887
49899 - Concanavalin A-like lectins/glucanases
63887 - P-domain of calnexin/calreticulin | 0 | DIRECT |
53300,69179
53300 - vWA-like
69179 - Integrin domains | 0 | DIRECT |
100950,100950
100950 - NagB/RpiA/CoA transferase-like
100950 - NagB/RpiA/CoA transferase-like | 0 | DIRECT |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | DIRECT |
50249,55681
50249 - Nucleic acid-binding proteins
55681 - Class II aaRS and biotin synthetases | 0 | DIRECT |
81296,101898
81296 - E set domains
101898 - NHL repeat | 0 | DIRECT |
50405,50405
50405 - Actin-crosslinking proteins
50405 - Actin-crosslinking proteins | 0 | DIRECT |
57850,88697
57850 - RING/U-box
88697 - PUA domain-like | 0 | DIRECT |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0 | DIRECT |
57184,57610
57184 - Growth factor receptor domain
57610 - Thyroglobulin type-1 domain | 0 | DIRECT |
69012,55874
69012 - alpha-ketoacid dehydrogenase kinase, N-terminal domain
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | DIRECT |
-7,56112
-7 - CATH
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
57440,56436
57440 - Kringle-like
56436 - C-type lectin-like | 0 | DIRECT |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | DIRECT |
142921,47587
142921 - WGR domain-like
47587 - Domain of poly(ADP-ribose) polymerase | 0 | DIRECT |
141673,50800
141673 - MOSC N-terminal domain-like
50800 - PK beta-barrel domain-like | 0 | DIRECT |
48670,48097
48670 - Transducin (heterotrimeric G protein), gamma chain
48097 - Regulator of G-protein signaling, RGS | 0 | DIRECT |
82754,82754
82754 - C-terminal, gelsolin-like domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
51735,50129
51735 - NAD(P)-binding Rossmann-fold domains
50129 - GroES-like | 0 | DIRECT |
48034,55931
48034 - Guanido kinase N-terminal domain
55931 - Glutamine synthetase/guanido kinase | 0 | DIRECT |
47473,55550
47473 - EF-hand
55550 - SH2 domain | 0 | DIRECT |
57196,63825
57196 - EGF/Laminin
63825 - YWTD domain | 0 | DIRECT |
47668,47473
47668 - N-terminal domain of cbl (N-cbl)
47473 - EF-hand | 0 | DIRECT |
56112,56112
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
57184,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | DIRECT |
57903,51197
57903 - FYVE/PHD zinc finger
51197 - Clavaminate synthase-like | 0 | DIRECT |
56059,52210
56059 - Glutathione synthetase ATP-binding domain-like
52210 - Succinyl-CoA synthetase domains | 0 | DIRECT |
49899,48726
49899 - Concanavalin A-like lectins/glucanases
48726 - Immunoglobulin | 0 | DIRECT |
49417,47719
49417 - p53-like transcription factors
47719 - p53 tetramerization domain | 0 | DIRECT |
51045,51045
51045 - WW domain
51045 - WW domain | 0 | DIRECT |
56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like | 0 | DIRECT |
161093,161093
161093 - MgtE membrane domain-like
161093 - MgtE membrane domain-like | 0 | DIRECT |
57581,57581
57581 - TB module/8-cys domain
57581 - TB module/8-cys domain | 0 | DIRECT |
55021,56534
55021 - ACT-like
56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | DIRECT |
54160,54160
54160 - Chromo domain-like
54160 - Chromo domain-like | 0 | DIRECT |
50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
57196,57535
57196 - EGF/Laminin
57535 - Complement control module/SCR domain | 0 | DIRECT |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0 | DIRECT |
82109,100909
82109 - MIR domain
100909 - IP3 receptor type 1 binding core, domain 2 | 0 | DIRECT |
50677,52374
50677 - ValRS/IleRS/LeuRS editing domain
52374 - Nucleotidylyl transferase | 0 | DIRECT |
101912,103575
101912 - Sema domain
103575 - Plexin repeat | 0 | DIRECT |
48403,48452
48403 - Ankyrin repeat
48452 - TPR-like | 0 | DIRECT |
101288,50156
101288 - L27 domain
50156 - PDZ domain-like | 0 | DIRECT |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
50044,52540
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
57889,50729
57889 - Cysteine-rich domain
50729 - PH domain-like | 0 | DIRECT |
57603,57603
57603 - FnI-like domain
57603 - FnI-like domain | 0 | DIRECT |
103637,103637
103637 - CCHHC domain
103637 - CCHHC domain | 0 | DIRECT |
54826,51604
54826 - Enolase N-terminal domain-like
51604 - Enolase C-terminal domain-like | 0 | DIRECT |
48350,50044
48350 - GTPase activation domain, GAP
50044 - SH3-domain | 0 | DIRECT |
57424,57184
57424 - LDL receptor-like module
57184 - Growth factor receptor domain | 0 | DIRECT |
53098,54928
53098 - Ribonuclease H-like
54928 - RNA-binding domain, RBD | 0 | DIRECT |
82185,82185
82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 0 | DIRECT |
53187,47672
53187 - Zn-dependent exopeptidases
47672 - Transferrin receptor-like dimerisation domain | 0 | DIRECT |
110083,55909
110083 - Peptidylarginine deiminase Pad4, middle domain
55909 - Pentein | 0 | DIRECT |
50729,50156
50729 - PH domain-like
50156 - PDZ domain-like | 0 | DIRECT |
55753,82754
55753 - Actin depolymerizing proteins
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
52540,51045
52540 - P-loop containing nucleoside triphosphate hydrolases
51045 - WW domain | 0 | DIRECT |
103647,103647
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat | 0 | DIRECT |
-7,52540
-7 - CATH
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
57903,47370
57903 - FYVE/PHD zinc finger
47370 - Bromodomain | 0 | DIRECT |
51230,47005
51230 - Single hybrid motif
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | DIRECT |
55681,52954
55681 - Class II aaRS and biotin synthetases
52954 - Class II aaRS ABD-related | 0 | DIRECT |
48452,48371
48452 - TPR-like
48371 - ARM repeat | 0 | DIRECT |
52540,50729
52540 - P-loop containing nucleoside triphosphate hydrolases
50729 - PH domain-like | 0 | DIRECT |
54511,57184
54511 - GFP-like
57184 - Growth factor receptor domain | 0 | DIRECT |
100895,100895
100895 - Kazal-type serine protease inhibitors
100895 - Kazal-type serine protease inhibitors | 0 | DIRECT |
56112,50729
56112 - Protein kinase-like (PK-like)
50729 - PH domain-like | 0 | DIRECT |
49785,53187
49785 - Galactose-binding domain-like
53187 - Zn-dependent exopeptidases | 0 | DIRECT |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0 | DIRECT |
48452,48403
48452 - TPR-like
48403 - Ankyrin repeat | 0 | DIRECT |
50156,50044
50156 - PDZ domain-like
50044 - SH3-domain | 0 | DIRECT |
53328,50486
53328 - Formyltransferase
50486 - FMT C-terminal domain-like | 0 | DIRECT |
49503,49503
49503 - Cupredoxins
49503 - Cupredoxins | 0 | DIRECT |
51419,50621
51419 - PLP-binding barrel
50621 - Alanine racemase C-terminal domain-like | 0 | DIRECT |
57667,140996
57667 - beta-beta-alpha zinc fingers
140996 - Hermes dimerisation domain | 0 | DIRECT |
52540,53254
52540 - P-loop containing nucleoside triphosphate hydrolases
53254 - Phosphoglycerate mutase-like | 0 | DIRECT |
55486,82895
55486 - Metalloproteases ("zincins"), catalytic domain
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
55753,55753
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins | 0 | DIRECT |
50729,55550
50729 - PH domain-like
55550 - SH2 domain | 0 | DIRECT |
52374,47323
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
54534,54534
54534 - FKBP-like
54534 - FKBP-like | 0 | DIRECT |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.001724 | INHERITED FROM: napabucasin || Cycloparaffins || Cyclohexenes || Pregnenediones || Progesterone || ML 7 |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.002457 | INHERITED FROM: 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol || 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.04001 | INHERITED FROM: Cyclopentane Monoterpenes || Tretinoin || Indenes || 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid || Fluorenes || Dehydroepiandrosterone || Cardenolides || Cholic Acids || Polyketides || Ketosteroids || Anthracenes || fenvalerate || 3-benzylidene camphor || pyrene || cyhalothrin || Cyclohexanecarboxylic Acids || Permethrin || Chenodeoxycholic Acid || 3-acetyldeoxynivalenol || Vitamin A || 17-alpha-Hydroxyprogesterone || Pyrethrins || Cholesterol || Bridged-Ring Compounds || Simvastatin || Mifepristone || Rifamycins || LG 100268 || versalide || Cyclohexanones || SR 11237 || 2,2-bis(4-glycidyloxyphenyl)propane || Fulvestrant || Cycloparaffins || Androstanes || 1-hydroxypyrene || phantolid || Methylprednisolone || Bicyclic Monoterpenes || 1-Naphthylisothiocyanate || Medroxyprogesterone || Digitoxin || Cyclopentanes || Epirubicin || Hydroxycholesterols || Carbaryl || diisononyl 1,2-cyclohexanedicarboxylic acid || 2,6-diisopropylnaphthalene || Budesonide || Bexarotene || Toxaphene || Cyclohexenes || Norethindrone Acetate || Medroxyprogesterone Acetate || Fenretinide || Cholanes || Carotenoids || Am 580 || resmethrin || Bridged Bicyclo Compounds || Ciclopirox || Retinoids || pirarubicin || Sterols || Cholestenes || acetyl methyl tetramethyl tetralin || Cardiac Glycosides || Pregnadienediols || Alitretinoin || sulindac sulfone || enzacamene || Cholestanes || Digitalis Glycosides || Trichothecenes || Idarubicin || Phenanthrenes || 1,1-bis(4-hydroxyphenyl)cyclohexane || Naphthalenes || Triamcinolone || Bile Acids and Salts || 17-Ketosteroids || Cardanolides || Lactams, Macrocyclic || Estrone || Ethers, Cyclic || Estriol |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0.04508 | INHERITED FROM: tamibarotene |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 0.05073 | INHERITED FROM: apocarotenal || Ketosteroids || Microcystins || apple polyphenol extract || Tetrapyrroles || Cyclohexanes || Bile Pigments || microcystin RR || beta Carotene || Androstenedione || dibenzo(a,l)pyrene || Spiro Compounds || Naphthalenesulfonates || Okadaic Acid || 17-Ketosteroids |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0.05952 | INHERITED FROM: Benzopyrenes || Hydroxycholecalciferols || benzo(e)pyrene || Dihydroxycholecalciferols || Calcitriol || Estradiol |
47031,50729
47031 - Second domain of FERM
50729 - PH domain-like | 0.06232 | INHERITED FROM: Daunorubicin || Benzopyrenes || Pyrenes || Doxorubicin |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.06418 | INHERITED FROM: Cyclohexanones || tamibarotene || 4-acetylantroquinonol B |
54236,47031
54236 - Ubiquitin-like
47031 - Second domain of FERM | 0.0917 | INHERITED FROM: Benzopyrenes |
81660,56784
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like | 0.1108 | INHERITED FROM: Cardenolides || Strophanthins || Cardiac Glycosides || Ouabain || Cardanolides |
57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.1137 | INHERITED FROM: tanshinone |
81296,81296
81296 - E set domains
81296 - E set domains | 0.127 | INHERITED FROM: Fused-Ring Compounds || Estradiol |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0.1417 | INHERITED FROM: Anthracenes || Cyclohexanecarboxylic Acids || Tetracyclines || Simvastatin || bufalin || Mifepristone || 1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one || 3-caffeoyl-4-dihydrocaffeoylquinic acid || Androstadienes || Lovastatin || Wortmannin || Tetrapyrroles || cyclo(Trp-Asp-Pro-Val-Leu) || Hydroxycholecalciferols || Paclitaxel || manganese(III)-tetrakis(4-benzoic acid)porphyrin || pyrazolanthrone || Chlorogenic Acid || Doxycycline || Cholestenones || Pregnenediones || Progesterone || Sterols || Cholestenes || Cardiac Glycosides || Spiro Compounds || Porphyrins || Dihydroxycholecalciferols || Secosteroids || Ouabain || mibolerone || Nandrolone || Calcitriol || Cardanolides || Cyclodecanes || Estradiol |
57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0.1572 | INHERITED FROM: Norgestrel || Cholic Acids |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.1584 | INHERITED FROM: Anthracenes || cobaltiprotoporphyrin || Tetracyclines || Simvastatin || Mifepristone || Lovastatin || Paclitaxel || manganese(III)-tetrakis(4-benzoic acid)porphyrin || pyrazolanthrone || Metalloporphyrins || Doxycycline || Tetracycline || Estradiol |
52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.1765 | INHERITED FROM: Androstanols || Sesquiterpenes, Guaiane || Cycloheptanes || Sesquiterpenes, Eudesmane || Cyclosporins || Dihydrotestosterone || Thapsigargin || Polycyclic Sesquiterpenes |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.2011 | INHERITED FROM: Simvastatin || Pregnenediones |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.2445 | INHERITED FROM: Indenes || 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid || Brassinosteroids || Cardenolides || Polyketides || Anthracenes || triptolide || LG 100268 || Wortmannin || Fulvestrant || 2-Methoxyestradiol || Hydroxycholecalciferols || Paclitaxel || HS 1200 || HS-1199 || Steroids, Heterocyclic || HS 1183 || HS 1030 || Sterols || Cholestenes || Cardiac Glycosides || AGN 194204 || Ursodeoxycholic Acid || Spiro Compounds || apicidin || Cholestanes || Sulindac || Phenanthrenes || Dihydroxycholecalciferols || tylophorine || Secosteroids || brassinolide || Ouabain || Calcitriol || seocalcitol || Cardanolides || Cyclodecanes |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0.2883 | INHERITED FROM: 3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol || Sesquiterpenes, Guaiane || Cycloheptanes || Sesquiterpenes, Eudesmane || dibenzo(a,l)pyrene || Thapsigargin || Polycyclic Sesquiterpenes |
54001,49758
54001 - Cysteine proteinases
49758 - Calpain large subunit, middle domain (domain III) | 0.3021 | INHERITED FROM: glycidamide || Menthol || Cyclohexanols || Cyclohexane Monoterpenes || Epoxy Compounds |
57850,49599
57850 - RING/U-box
49599 - TRAF domain-like | 0.3021 | INHERITED FROM: Menthol || Cyclohexane Monoterpenes |
56784,81665
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.3696 | INHERITED FROM: Cardenolides || Strophanthins || Cardiac Glycosides || Ouabain || Cardanolides |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0.3717 | INHERITED FROM: Sesquiterpenes, Guaiane || Cycloheptanes || Sesquiterpenes, Eudesmane || Thapsigargin || Polycyclic Sesquiterpenes |
54236,54236
54236 - Ubiquitin-like
54236 - Ubiquitin-like | 0.3717 | INHERITED FROM: Vitamin K || Spiro Compounds || Vitamin K 3 |
49758,47473
49758 - Calpain large subunit, middle domain (domain III)
47473 - EF-hand | 0.4127 | INHERITED FROM: Menthol || Cyclohexane Monoterpenes |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.4127 | INHERITED FROM: Cyproterone Acetate || eldecalcitol || Polyketides || Ketosteroids || Chenodeoxycholic Acid || Rifamycins || Fulvestrant || Macrolides || Cyclopentanes || Cyproterone || dihydroxy-vitamin D3 || Steroids, Chlorinated || testosterone-3-carboxymethyloxime-bovine serum albumin conjugate || Rifampin || Metribolone || 17-Ketosteroids || Lactams, Macrocyclic || Deoxycholic Acid |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0.5065 | INHERITED FROM: Indenes || Polyketides || Podophyllotoxin || Anthracenes || Fulvestrant || sulindac sulfide || Paclitaxel || Cyclopentanes || Epirubicin || Tetrahydronaphthalenes || Sulindac || Mitoxantrone || Cyclodecanes || Etoposide |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0.5065 | INHERITED FROM: Indenes || Polyketides || Podophyllotoxin || Anthracenes || Fulvestrant || sulindac sulfide || Paclitaxel || Cyclopentanes || Epirubicin || Tetrahydronaphthalenes || Sulindac || Mitoxantrone || Cyclodecanes || Etoposide |
52777,52777
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases | 0.5065 | INHERITED FROM: Cholic Acids || Cholanes || Bile Acids and Salts || Deoxycholic Acid |
63411,63411
63411 - LuxS/MPP-like metallohydrolase
63411 - LuxS/MPP-like metallohydrolase | 0.5065 | INHERITED FROM: Isotretinoin |
47454,57959
47454 - A DNA-binding domain in eukaryotic transcription factors
57959 - Leucine zipper domain | 0.526 | INHERITED FROM: Tretinoin || Cholic Acids || obeticholic acid || Anthracenes || Vitamin A || deoxynivalenol || 9,10-dihydro-9,10-dihydroxybenzo(a)pyrene || Tetrapyrroles || Cyclohexenes || Hemin || Cholanes || Retinoids || Vitamin K || Spiro Compounds || Sertraline || Trichothecenes || Rifampin || Bile Acids and Salts || 1-Naphthylamine || Deoxycholic Acid || Vitamin K 3 || Epoxy Compounds |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0.5578 | INHERITED FROM: Erythromycin || Tetracyclines || tamibarotene || Tetrahydronaphthalenes || Minocycline || Naphthalenes || Isotretinoin |
74788,75632
74788 - Cullin repeat-like
75632 - Cullin homology domain | 0.5632 | INHERITED FROM: Dihydroxydihydrobenzopyrenes || 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
57535,49854
57535 - Complement control module/SCR domain
49854 - Spermadhesin, CUB domain | 0.5632 | INHERITED FROM: benzo(e)pyrene |
81301,81631
81301 - Nucleotidyltransferase
81631 - PAP/OAS1 substrate-binding domain | 0.5643 | INHERITED FROM: Prednisolone || tamibarotene || Methylprednisolone |
57889,57889
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0.5643 | INHERITED FROM: Cholic Acids || Polyketides || Bryostatins || Macrolides || Deoxycholic Acid |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.6444 | INHERITED FROM: Adamantane || Bridged-Ring Compounds || Ivermectin || CD 437 || Okadaic Acid || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid |
64593,64593
64593 - Intermediate filament protein, coiled coil region
64593 - Intermediate filament protein, coiled coil region | 0.6576 | INHERITED FROM: ethyl-p-((E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-1-propenyl)benzoic acid || beta Carotene || 4-oxoretinoic acid || Alitretinoin |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0.6866 | INHERITED FROM: ethinyl estradiol-desogestrel combination || Cardenolides || Cholic Acids || Anthracenes || Dactinomycin || Taurocholic Acid || Cyclohexanecarboxylic Acids || Norpregnenes || Simvastatin || Lovastatin || Tetrapyrroles || Paclitaxel || Propranolol || Medroxyprogesterone || Strophanthins || Beclomethasone || Medroxyprogesterone Acetate || Pregnenes || Cholanes || Pregnenediones || Progesterone || Norsteroids || Cardiac Glycosides || Alitretinoin || Spiro Compounds || Norpregnatrienes || Porphyrins || Phenanthrenes || Naphthalenes || Steroids, Chlorinated || Gestodene || Ouabain || Hydroxyprogesterones || Isotretinoin || Cardanolides || Lactams, Macrocyclic |
103473,100895
103473 - MFS general substrate transporter
100895 - Kazal-type serine protease inhibitors | 0.6866 | INHERITED FROM: Ketosteroids || Rifamycins || Lithocholic Acid || estrone sulfate || Rifampin || 17-Ketosteroids || Lactams, Macrocyclic || Estrone |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0.6866 | INHERITED FROM: Adamantane || Bridged-Ring Compounds || Ivermectin || CD 437 || Okadaic Acid || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid |
52540,50447
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins | 0.7225 | INHERITED FROM: Metribolone |
46785,144074
46785 - "Winged helix" DNA-binding domain
144074 - E2F-DP heterodimerization region | 0.7716 | INHERITED FROM: Menthol || Paclitaxel || Cyclohexanols || Naphthalenes || Cyclohexane Monoterpenes |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0.7824 | INHERITED FROM: aurin || bufalin || Hemin || Ivermectin || Thiostrepton || yessotoxin |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.8501 | INHERITED FROM: carvone || Pregnanolone || Rocuronium || Bridged-Ring Compounds || 13,19-didesmethyl spirolide C || beta-thujone || menthone || N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline || Vecuronium Bromide || Picrotoxin || Pancuronium || Camphor || tetramethylenedisulfotetramine || isoborneol || 13-desmethylspirolide C |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.9184 | INHERITED FROM: 5H-benzo(4,5)cyclohepta(1,2-b)pyridin-5-one || Benzocycloheptenes |
46579,64593
46579 - Prefoldin
64593 - Intermediate filament protein, coiled coil region | 0.9336 | INHERITED FROM: Indenes || ethyl-p-((E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-1-propenyl)benzoic acid || Cholecalciferol || sulindac sulfide || Hydroxycholecalciferols || Bexarotene || beta Carotene || 4-oxoretinoic acid || Alitretinoin || Sulindac || Dihydroxycholecalciferols || Secosteroids || Calcitriol || Isotretinoin || 4-oxoretinol |
52518,52922
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 0.9363 | INHERITED FROM: Isotretinoin |
49313,49313
49313 - Cadherin-like
49313 - Cadherin-like | 0.9566 | INHERITED FROM: jasplakinolide || dibenzo(a,l)pyrene |
47986,52540
47986 - DEATH domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: benzo(e)pyrene |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57850,52540
57850 - RING/U-box
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
56112,64268
56112 - Protein kinase-like (PK-like)
64268 - PX domain | 0 | Direct |
54637,54637
54637 - Thioesterase/thiol ester dehydrase-isomerase
54637 - Thioesterase/thiol ester dehydrase-isomerase | 0 | Direct |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0 | Direct |
57889,48350
57889 - Cysteine-rich domain
48350 - GTPase activation domain, GAP | 0 | Direct |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0 | Direct |
48452,46785
48452 - TPR-like
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
49410,50242
49410 - Alpha-macroglobulin receptor domain
50242 - TIMP-like | 0 | Direct |
50993,53474
50993 - Peptidase/esterase 'gauge' domain
53474 - alpha/beta-Hydrolases | 0 | Direct |
48726,56436
48726 - Immunoglobulin
56436 - C-type lectin-like | 0 | Direct |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0 | Direct |
53300,49265
53300 - vWA-like
49265 - Fibronectin type III | 0 | Direct |
52047,48371
52047 - RNI-like
48371 - ARM repeat | 0 | Direct |
103575,81296
103575 - Plexin repeat
81296 - E set domains | 0 | Direct |
50044,48065
50044 - SH3-domain
48065 - DBL homology domain (DH-domain) | 0 | Direct |
53223,51735
53223 - Aminoacid dehydrogenase-like, N-terminal domain
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
54791,54791
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | Direct |
63763,57903
63763 - SAND domain-like
57903 - FYVE/PHD zinc finger | 0 | Direct |
57889,49562
57889 - Cysteine-rich domain
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
82199,57903
82199 - SET domain
57903 - FYVE/PHD zinc finger | 0 | Direct |
47370,47370
47370 - Bromodomain
47370 - Bromodomain | 0 | Direct |
100895,50494
100895 - Kazal-type serine protease inhibitors
50494 - Trypsin-like serine proteases | 0 | Direct |
56024,56024
56024 - Phospholipase D/nuclease
56024 - Phospholipase D/nuclease | 0 | Direct |
100895,47473
100895 - Kazal-type serine protease inhibitors
47473 - EF-hand | 0 | Direct |
53822,53850
53822 - Periplasmic binding protein-like I
53850 - Periplasmic binding protein-like II | 0 | Direct |
48425,50729
48425 - Sec7 domain
50729 - PH domain-like | 0 | Direct |
56176,55103
56176 - FAD-binding/transporter-associated domain-like
55103 - FAD-linked oxidases, C-terminal domain | 0 | Direct |
47353,109640
47353 - Retrovirus capsid dimerization domain-like
109640 - KRAB domain (Kruppel-associated box) | 0 | Direct |
81995,81811
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24 | 0 | Direct |
49562,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain | 0 | Direct |
57756,57756
57756 - Retrovirus zinc finger-like domains
57756 - Retrovirus zinc finger-like domains | 0 | Direct |
47473,57850
47473 - EF-hand
57850 - RING/U-box | 0 | Direct |
52540,47917
52540 - P-loop containing nucleoside triphosphate hydrolases
47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase | 0 | Direct |
54534,47473
54534 - FKBP-like
47473 - EF-hand | 0 | Direct |
49854,57196
49854 - Spermadhesin, CUB domain
57196 - EGF/Laminin | 0 | Direct |
57184,49854
57184 - Growth factor receptor domain
49854 - Spermadhesin, CUB domain | 0 | Direct |
53300,69318
53300 - vWA-like
69318 - Integrin alpha N-terminal domain | 0 | Direct |
63501,50242
63501 - Frizzled cysteine-rich domain
50242 - TIMP-like | 0 | Direct |
54768,-9
54768 - dsRNA-binding domain-like
-9 - PDB | 0 | Direct |
57362,57362
57362 - BPTI-like
57362 - BPTI-like | 0 | Direct |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0 | Direct |
47576,48065
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain) | 0 | Direct |
48726,56112
48726 - Immunoglobulin
56112 - Protein kinase-like (PK-like) | 0 | Direct |
52949,52949
52949 - Macro domain-like
52949 - Macro domain-like | 0 | Direct |
57184,100895
57184 - Growth factor receptor domain
100895 - Kazal-type serine protease inhibitors | 0 | Direct |
48726,82895
48726 - Immunoglobulin
82895 - TSP-1 type 1 repeat | 0 | Direct |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0 | Direct |
-8,54980
-8 - ECOD
54980 - EF-G C-terminal domain-like | 0 | Direct |
48350,55961
48350 - GTPase activation domain, GAP
55961 - Bet v1-like | 0 | Direct |
54928,90209
54928 - RNA-binding domain, RBD
90209 - Ran binding protein zinc finger-like | 0 | Direct |
57424,49899
57424 - LDL receptor-like module
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
48371,46785
48371 - ARM repeat
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
51206,51206
51206 - cAMP-binding domain-like
51206 - cAMP-binding domain-like | 0 | Direct |
82754,55753
82754 - C-terminal, gelsolin-like domain of Sec23/24
55753 - Actin depolymerizing proteins | 0 | Direct |
53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | Direct |
57196,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
100895,48726
100895 - Kazal-type serine protease inhibitors
48726 - Immunoglobulin | 0 | Direct |
81811,82754
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
64268,49562
64268 - PX domain
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
52283,51735
52283 - Formate/glycerate dehydrogenase catalytic domain-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
57424,57196
57424 - LDL receptor-like module
57196 - EGF/Laminin | 0 | Direct |
57581,57196
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0 | Direct |
57863,50729
57863 - ArfGap/RecO-like zinc finger
50729 - PH domain-like | 0 | Direct |
47203,47203
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
47676,46942
47676 - Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
46942 - Elongation factor TFIIS domain 2 | 0 | Direct |
53187,55031
53187 - Zn-dependent exopeptidases
55031 - Bacterial exopeptidase dimerisation domain | 0 | Direct |
63737,55486
63737 - Leukotriene A4 hydrolase N-terminal domain
55486 - Metalloproteases ("zincins"), catalytic domain | 0 | Direct |
49503,110083
49503 - Cupredoxins
110083 - Peptidylarginine deiminase Pad4, middle domain | 0 | Direct |
51905,55424
51905 - FAD/NAD(P)-binding domain
55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain | 0 | Direct |
117839,56399
117839 - WWE domain
56399 - ADP-ribosylation | 0 | Direct |
57196,49854
57196 - EGF/Laminin
49854 - Spermadhesin, CUB domain | 0 | Direct |
47473,103506
47473 - EF-hand
103506 - Mitochondrial carrier | 0 | Direct |
55326,56042
55326 - PurM N-terminal domain-like
56042 - PurM C-terminal domain-like | 0 | Direct |
48371,101447
48371 - ARM repeat
101447 - Formin homology 2 domain (FH2 domain) | 0 | Direct |
57196,69687
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0 | Direct |
52025,53187
52025 - PA domain
53187 - Zn-dependent exopeptidases | 0 | Direct |
57938,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
47113,-7
47113 - Histone-fold
-7 - CATH | 0 | Direct |
52540,48340
52540 - P-loop containing nucleoside triphosphate hydrolases
48340 - Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain | 0 | Direct |
54236,57889
54236 - Ubiquitin-like
57889 - Cysteine-rich domain | 0 | Direct |
57196,50494
57196 - EGF/Laminin
50494 - Trypsin-like serine proteases | 0 | Direct |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | Direct |
50494,50156
50494 - Trypsin-like serine proteases
50156 - PDZ domain-like | 0 | Direct |
57492,74650
57492 - Trefoil
74650 - Galactose mutarotase-like | 0 | Direct |
57196,49265
57196 - EGF/Laminin
49265 - Fibronectin type III | 0 | Direct |
69572,69572
69572 - Activating enzymes of the ubiquitin-like proteins
69572 - Activating enzymes of the ubiquitin-like proteins | 0 | Direct |
49599,49599
49599 - TRAF domain-like
49599 - TRAF domain-like | 0 | Direct |
56801,56801
56801 - Acetyl-CoA synthetase-like
56801 - Acetyl-CoA synthetase-like | 0 | Direct |
54695,54695
54695 - POZ domain
54695 - POZ domain | 0 | Direct |
103575,48726
103575 - Plexin repeat
48726 - Immunoglobulin | 0 | Direct |
81324,53850
81324 - Voltage-gated potassium channels
53850 - Periplasmic binding protein-like II | 0 | Direct |
90188,53649
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like | 0 | Direct |
46966,51045
46966 - Spectrin repeat
51045 - WW domain | 0 | Direct |
54160,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
48403,50044
48403 - Ankyrin repeat
50044 - SH3-domain | 0 | Direct |
81837,50978
81837 - BEACH domain
50978 - WD40 repeat-like | 0 | Direct |
47060,55681
47060 - S15/NS1 RNA-binding domain
55681 - Class II aaRS and biotin synthetases | 0 | Direct |
52540,57774
52540 - P-loop containing nucleoside triphosphate hydrolases
57774 - Microbial and mitochondrial ADK, insert "zinc finger" domain | 0 | Direct |
47473,57610
47473 - EF-hand
57610 - Thyroglobulin type-1 domain | 0 | Direct |
48403,47986
48403 - Ankyrin repeat
47986 - DEATH domain | 0 | Direct |
48371,49348
48371 - ARM repeat
49348 - Clathrin adaptor appendage domain | 0 | Direct |
47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | Direct |
52821,52799
52821 - Rhodanese/Cell cycle control phosphatase
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
53300,49899
53300 - vWA-like
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
48366,47473
48366 - Ras GEF
47473 - EF-hand | 0 | Direct |
74650,51445
74650 - Galactose mutarotase-like
51445 - (Trans)glycosidases | 0 | Direct |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | Direct |
47986,47986
47986 - DEATH domain
47986 - DEATH domain | 0 | Direct |
50370,57440
50370 - Ricin B-like lectins
57440 - Kringle-like | 0 | Direct |
81324,81327
81324 - Voltage-gated potassium channels
81327 - Small-conductance potassium channel | 0 | Direct |
52980,47781
52980 - Restriction endonuclease-like
47781 - RuvA domain 2-like | 0 | Direct |
49695,50370
49695 - gamma-Crystallin-like
50370 - Ricin B-like lectins | 0 | Direct |
54211,55666
54211 - Ribosomal protein S5 domain 2-like
55666 - Ribonuclease PH domain 2-like | 0 | Direct |
47769,47769
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain | 0 | Direct |
49742,49742
49742 - PHM/PNGase F
49742 - PHM/PNGase F | 0 | Direct |
63748,57903
63748 - Tudor/PWWP/MBT
57903 - FYVE/PHD zinc finger | 0 | Direct |
50044,47769
50044 - SH3-domain
47769 - SAM/Pointed domain | 0 | Direct |
50447,-8
50447 - Translation proteins
-8 - ECOD | 0 | Direct |
53738,55957
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | Direct |
53098,56672
53098 - Ribonuclease H-like
56672 - DNA/RNA polymerases | 0 | Direct |
54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 0 | Direct |
57196,57581
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0 | Direct |
55550,57850
55550 - SH2 domain
57850 - RING/U-box | 0 | Direct |
57581,57184
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain | 0 | Direct |
50978,50998
50978 - WD40 repeat-like
50998 - Quinoprotein alcohol dehydrogenase-like | 0 | Direct |
56059,51246
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0 | Direct |
56487,56487
56487 - SRCR-like
56487 - SRCR-like | 0 | Direct |
54001,143791
54001 - Cysteine proteinases
143791 - DUSP-like | 0 | Direct |
55186,55681
55186 - ThrRS/AlaRS common domain
55681 - Class II aaRS and biotin synthetases | 0 | Direct |
47661,58038
47661 - t-snare proteins
58038 - SNARE fusion complex | 0 | Direct |
48403,52540
48403 - Ankyrin repeat
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
48452,57850
48452 - TPR-like
57850 - RING/U-box | 0 | Direct |
46689,57667
46689 - Homeodomain-like
57667 - beta-beta-alpha zinc fingers | 0 | Direct |
57184,57581
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain | 0 | Direct |
55486,49854
55486 - Metalloproteases ("zincins"), catalytic domain
49854 - Spermadhesin, CUB domain | 0 | Direct |
54403,54403
54403 - Cystatin/monellin
54403 - Cystatin/monellin | 0 | Direct |
47576,143575
47576 - Calponin-homology domain, CH-domain
143575 - GAS2 domain-like | 0 | Direct |
102712,-7
102712 - JAB1/MPN domain
-7 - CATH | 0 | Direct |
49899,57424
49899 - Concanavalin A-like lectins/glucanases
57424 - LDL receptor-like module | 0 | Direct |
63825,57196
63825 - YWTD domain
57196 - EGF/Laminin | 0 | Direct |
52743,49785
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | Direct |
54416,49998
54416 - Amine oxidase N-terminal region
49998 - Amine oxidase catalytic domain | 0 | Direct |
48464,89009
48464 - ENTH/VHS domain
89009 - GAT-like domain | 0 | Direct |
47986,52129
47986 - DEATH domain
52129 - Caspase-like | 0 | Direct |
117018,56091
117018 - ATP-dependent DNA ligase DNA-binding domain
56091 - DNA ligase/mRNA capping enzyme, catalytic domain | 0 | Direct |
49493,49493
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
57196,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0 | Direct |
49785,49785
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like | 0 | Direct |
90209,90209
90209 - Ran binding protein zinc finger-like
90209 - Ran binding protein zinc finger-like | 0 | Direct |
47862,47862
47862 - Saposin
47862 - Saposin | 0 | Direct |
56672,100879
56672 - DNA/RNA polymerases
100879 - Lesion bypass DNA polymerase (Y-family), little finger domain | 0 | Direct |
54236,48366
54236 - Ubiquitin-like
48366 - Ras GEF | 0 | Direct |
52540,90123
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0 | Direct |
90193,90193
90193 - Notch domain
90193 - Notch domain | 0 | Direct |
63748,82199
63748 - Tudor/PWWP/MBT
82199 - SET domain | 0 | Direct |
81271,55186
81271 - TGS-like
55186 - ThrRS/AlaRS common domain | 0 | Direct |
54534,48452
54534 - FKBP-like
48452 - TPR-like | 0 | Direct |
53300,53300
53300 - vWA-like
53300 - vWA-like | 0 | Direct |
46785,54928
46785 - "Winged helix" DNA-binding domain
54928 - RNA-binding domain, RBD | 0 | Direct |
55486,48371
55486 - Metalloproteases ("zincins"), catalytic domain
48371 - ARM repeat | 0 | Direct |
55874,54211
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
54211 - Ribosomal protein S5 domain 2-like | 0 | Direct |
48371,49899
48371 - ARM repeat
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
69065,54768
69065 - RNase III domain-like
54768 - dsRNA-binding domain-like | 0 | Direct |
51445,51445
51445 - (Trans)glycosidases
51445 - (Trans)glycosidases | 0 | Direct |
53732,52016
53732 - Aconitase iron-sulfur domain
52016 - LeuD/IlvD-like | 0 | Direct |
50044,56112
50044 - SH3-domain
56112 - Protein kinase-like (PK-like) | 0 | Direct |
50729,48350
50729 - PH domain-like
48350 - GTPase activation domain, GAP | 0 | Direct |
46966,47473
46966 - Spectrin repeat
47473 - EF-hand | 0 | Direct |
49313,49899
49313 - Cadherin-like
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
53927,53927
53927 - Cytidine deaminase-like
53927 - Cytidine deaminase-like | 0 | Direct |
69318,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0 | Direct |
102848,54236
102848 - NSFL1 (p97 ATPase) cofactor p47, SEP domain
54236 - Ubiquitin-like | 0 | Direct |
48371,-7
48371 - ARM repeat
-7 - CATH | 0 | Direct |
52799,52799
52799 - (Phosphotyrosine protein) phosphatases II
52799 - (Phosphotyrosine protein) phosphatases II | 0 | Direct |
47459,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain) | 0 | Direct |
51905,54373
51905 - FAD/NAD(P)-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0 | Direct |
53784,53784
53784 - Phosphofructokinase
53784 - Phosphofructokinase | 0 | Direct |
82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | Direct |
57184,49899
57184 - Growth factor receptor domain
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | Direct |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | Direct |
54897,52743
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like | 0 | Direct |
161111,160240
161111 - Cation efflux protein transmembrane domain-like
160240 - Cation efflux protein cytoplasmic domain-like | 0 | Direct |
100920,100934
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
47005,52777
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
52777 - CoA-dependent acyltransferases | 0 | Direct |
81698,81698
81698 - FF domain
81698 - FF domain | 0 | Direct |
55550,158235
55550 - SH2 domain
158235 - SOCS box-like | 0 | Direct |
50156,52540
50156 - PDZ domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
88713,88688
88713 - Glycoside hydrolase/deacetylase
88688 - Families 57/38 glycoside transferase middle domain | 0 | Direct |
57535,50494
57535 - Complement control module/SCR domain
50494 - Trypsin-like serine proteases | 0 | Direct |
54211,55060
54211 - Ribosomal protein S5 domain 2-like
55060 - GHMP Kinase, C-terminal domain | 0 | Direct |
56091,50249
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | Direct |
47473,57889
47473 - EF-hand
57889 - Cysteine-rich domain | 0 | Direct |
53850,53850
53850 - Periplasmic binding protein-like II
53850 - Periplasmic binding protein-like II | 0 | Direct |
48350,50729
48350 - GTPase activation domain, GAP
50729 - PH domain-like | 0 | Direct |
103025,101790
103025 - Folate-binding domain
101790 - Aminomethyltransferase beta-barrel domain | 0 | Direct |
82109,82109
82109 - MIR domain
82109 - MIR domain | 0 | Direct |
56645,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
50104,50249
50104 - Translation proteins SH3-like domain
50249 - Nucleic acid-binding proteins | 0 | Direct |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0 | Direct |
50729,57903
50729 - PH domain-like
57903 - FYVE/PHD zinc finger | 0 | Direct |
57630,57196
57630 - GLA-domain
57196 - EGF/Laminin | 0 | Direct |
53300,81995
53300 - vWA-like
81995 - beta-sandwich domain of Sec23/24 | 0 | Direct |
49265,56112
49265 - Fibronectin type III
56112 - Protein kinase-like (PK-like) | 0 | Direct |
55753,47050
55753 - Actin depolymerizing proteins
47050 - VHP, Villin headpiece domain | 0 | Direct |
53187,49464
53187 - Zn-dependent exopeptidases
49464 - Carboxypeptidase regulatory domain-like | 0 | Direct |
53300,57184
53300 - vWA-like
57184 - Growth factor receptor domain | 0 | Direct |
52540,-7
52540 - P-loop containing nucleoside triphosphate hydrolases
-7 - CATH | 0 | Direct |
51045,56204
51045 - WW domain
56204 - Hect, E3 ligase catalytic domain | 0 | Direct |
81296,48239
81296 - E set domains
48239 - Terpenoid cyclases/Protein prenyltransferases | 0 | Direct |
50729,81837
50729 - PH domain-like
81837 - BEACH domain | 0 | Direct |
47576,140612
47576 - Calponin-homology domain, CH-domain
140612 - EB1 dimerisation domain-like | 0 | Direct |
51905,47576
51905 - FAD/NAD(P)-binding domain
47576 - Calponin-homology domain, CH-domain | 0 | Direct |
74924,74924
74924 - Cap-Gly domain
74924 - Cap-Gly domain | 0 | Direct |
52087,48350
52087 - CRAL/TRIO domain
48350 - GTPase activation domain, GAP | 0 | Direct |
54236,50729
54236 - Ubiquitin-like
50729 - PH domain-like | 0 | Direct |
110324,50249
110324 - Ribosomal L27 protein-like
50249 - Nucleic acid-binding proteins | 0 | Direct |
53901,53901
53901 - Thiolase-like
53901 - Thiolase-like | 0 | Direct |
100934,100934
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
49265,53300
49265 - Fibronectin type III
53300 - vWA-like | 0 | Direct |
54416,54416
54416 - Amine oxidase N-terminal region
54416 - Amine oxidase N-terminal region | 0 | Direct |
51045,47473
51045 - WW domain
47473 - EF-hand | 0 | Direct |
50129,51735
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
57184,63825
57184 - Growth factor receptor domain
63825 - YWTD domain | 0 | Direct |
81901,81901
81901 - HCP-like
81901 - HCP-like | 0 | Direct |
57667,90229
57667 - beta-beta-alpha zinc fingers
90229 - CCCH zinc finger | 0 | Direct |
48403,56112
48403 - Ankyrin repeat
56112 - Protein kinase-like (PK-like) | 0 | Direct |
52058,52047
52058 - L domain-like
52047 - RNI-like | 0 | Direct |
63748,63748
63748 - Tudor/PWWP/MBT
63748 - Tudor/PWWP/MBT | 0 | Direct |
57414,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like | 0 | Direct |
49348,55711
49348 - Clathrin adaptor appendage domain
55711 - Subdomain of clathrin and coatomer appendage domain | 0 | Direct |
56491,89811
56491 - A heparin-binding domain
89811 - Amyloid beta a4 protein copper binding domain (domain 2) | 0 | Direct |
57850,48452
57850 - RING/U-box
48452 - TPR-like | 0 | Direct |
64268,56112
64268 - PX domain
56112 - Protein kinase-like (PK-like) | 0 | Direct |
47587,56399
47587 - Domain of poly(ADP-ribose) polymerase
56399 - ADP-ribosylation | 0 | Direct |
50729,46785
50729 - PH domain-like
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
69179,69179
69179 - Integrin domains
69179 - Integrin domains | 0 | Direct |
46565,57938
46565 - Chaperone J-domain
57938 - DnaJ/Hsp40 cysteine-rich domain | 0 | Direct |
48552,48552
48552 - Serum albumin-like
48552 - Serum albumin-like | 0 | Direct |
57535,57196
57535 - Complement control module/SCR domain
57196 - EGF/Laminin | 0 | Direct |
56436,57535
56436 - C-type lectin-like
57535 - Complement control module/SCR domain | 0 | Direct |
57440,50494
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0 | Direct |
103657,48350
103657 - BAR/IMD domain-like
48350 - GTPase activation domain, GAP | 0 | Direct |
50998,50978
50998 - Quinoprotein alcohol dehydrogenase-like
50978 - WD40 repeat-like | 0 | Direct |
101690,53098
101690 - PAZ domain
53098 - Ribonuclease H-like | 0 | Direct |
82895,57424
82895 - TSP-1 type 1 repeat
57424 - LDL receptor-like module | 0 | Direct |
52113,52113
52113 - BRCT domain
52113 - BRCT domain | 0 | Direct |
63380,52343
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | Direct |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0 | Direct |
49723,48484
49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
48484 - Lipoxigenase | 0 | Direct |
46585,46585
46585 - HR1 repeat
46585 - HR1 repeat | 0 | Direct |
57903,63748
57903 - FYVE/PHD zinc finger
63748 - Tudor/PWWP/MBT | 0 | Direct |
103647,49899
103647 - TSP type-3 repeat
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
57184,82895
57184 - Growth factor receptor domain
82895 - TSP-1 type 1 repeat | 0 | Direct |
54277,50156
54277 - CAD & PB1 domains
50156 - PDZ domain-like | 0 | Direct |
49265,56496
49265 - Fibronectin type III
56496 - Fibrinogen C-terminal domain-like | 0 | Direct |
49899,63887
49899 - Concanavalin A-like lectins/glucanases
63887 - P-domain of calnexin/calreticulin | 0 | Direct |
53300,69179
53300 - vWA-like
69179 - Integrin domains | 0 | Direct |
100950,100950
100950 - NagB/RpiA/CoA transferase-like
100950 - NagB/RpiA/CoA transferase-like | 0 | Direct |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | Direct |
50249,55681
50249 - Nucleic acid-binding proteins
55681 - Class II aaRS and biotin synthetases | 0 | Direct |
81296,101898
81296 - E set domains
101898 - NHL repeat | 0 | Direct |
50405,50405
50405 - Actin-crosslinking proteins
50405 - Actin-crosslinking proteins | 0 | Direct |
57850,88697
57850 - RING/U-box
88697 - PUA domain-like | 0 | Direct |
57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0 | Direct |
57184,57610
57184 - Growth factor receptor domain
57610 - Thyroglobulin type-1 domain | 0 | Direct |
69012,55874
69012 - alpha-ketoacid dehydrogenase kinase, N-terminal domain
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | Direct |
-7,56112
-7 - CATH
56112 - Protein kinase-like (PK-like) | 0 | Direct |
57440,56436
57440 - Kringle-like
56436 - C-type lectin-like | 0 | Direct |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | Direct |
142921,47587
142921 - WGR domain-like
47587 - Domain of poly(ADP-ribose) polymerase | 0 | Direct |
141673,50800
141673 - MOSC N-terminal domain-like
50800 - PK beta-barrel domain-like | 0 | Direct |
48670,48097
48670 - Transducin (heterotrimeric G protein), gamma chain
48097 - Regulator of G-protein signaling, RGS | 0 | Direct |
82754,82754
82754 - C-terminal, gelsolin-like domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
51735,50129
51735 - NAD(P)-binding Rossmann-fold domains
50129 - GroES-like | 0 | Direct |
48034,55931
48034 - Guanido kinase N-terminal domain
55931 - Glutamine synthetase/guanido kinase | 0 | Direct |
47473,55550
47473 - EF-hand
55550 - SH2 domain | 0 | Direct |
57196,63825
57196 - EGF/Laminin
63825 - YWTD domain | 0 | Direct |
47668,47473
47668 - N-terminal domain of cbl (N-cbl)
47473 - EF-hand | 0 | Direct |
56112,56112
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0 | Direct |
57184,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | Direct |
57903,51197
57903 - FYVE/PHD zinc finger
51197 - Clavaminate synthase-like | 0 | Direct |
56059,52210
56059 - Glutathione synthetase ATP-binding domain-like
52210 - Succinyl-CoA synthetase domains | 0 | Direct |
49899,48726
49899 - Concanavalin A-like lectins/glucanases
48726 - Immunoglobulin | 0 | Direct |
49417,47719
49417 - p53-like transcription factors
47719 - p53 tetramerization domain | 0 | Direct |
51045,51045
51045 - WW domain
51045 - WW domain | 0 | Direct |
56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like | 0 | Direct |
161093,161093
161093 - MgtE membrane domain-like
161093 - MgtE membrane domain-like | 0 | Direct |
57581,57581
57581 - TB module/8-cys domain
57581 - TB module/8-cys domain | 0 | Direct |
55021,56534
55021 - ACT-like
56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0 | Direct |
54160,54160
54160 - Chromo domain-like
54160 - Chromo domain-like | 0 | Direct |
50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | Direct |
57196,57535
57196 - EGF/Laminin
57535 - Complement control module/SCR domain | 0 | Direct |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0 | Direct |
82109,100909
82109 - MIR domain
100909 - IP3 receptor type 1 binding core, domain 2 | 0 | Direct |
50677,52374
50677 - ValRS/IleRS/LeuRS editing domain
52374 - Nucleotidylyl transferase | 0 | Direct |
101912,103575
101912 - Sema domain
103575 - Plexin repeat | 0 | Direct |
48403,48452
48403 - Ankyrin repeat
48452 - TPR-like | 0 | Direct |
101288,50156
101288 - L27 domain
50156 - PDZ domain-like | 0 | Direct |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
50044,52540
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
57889,50729
57889 - Cysteine-rich domain
50729 - PH domain-like | 0 | Direct |
57603,57603
57603 - FnI-like domain
57603 - FnI-like domain | 0 | Direct |
103637,103637
103637 - CCHHC domain
103637 - CCHHC domain | 0 | Direct |
54826,51604
54826 - Enolase N-terminal domain-like
51604 - Enolase C-terminal domain-like | 0 | Direct |
48350,50044
48350 - GTPase activation domain, GAP
50044 - SH3-domain | 0 | Direct |
57424,57184
57424 - LDL receptor-like module
57184 - Growth factor receptor domain | 0 | Direct |
53098,54928
53098 - Ribonuclease H-like
54928 - RNA-binding domain, RBD | 0 | Direct |
82185,82185
82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 0 | Direct |
53187,47672
53187 - Zn-dependent exopeptidases
47672 - Transferrin receptor-like dimerisation domain | 0 | Direct |
110083,55909
110083 - Peptidylarginine deiminase Pad4, middle domain
55909 - Pentein | 0 | Direct |
50729,50156
50729 - PH domain-like
50156 - PDZ domain-like | 0 | Direct |
55753,82754
55753 - Actin depolymerizing proteins
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
52540,51045
52540 - P-loop containing nucleoside triphosphate hydrolases
51045 - WW domain | 0 | Direct |
103647,103647
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat | 0 | Direct |
-7,52540
-7 - CATH
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
57903,47370
57903 - FYVE/PHD zinc finger
47370 - Bromodomain | 0 | Direct |
51230,47005
51230 - Single hybrid motif
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex | 0 | Direct |
55681,52954
55681 - Class II aaRS and biotin synthetases
52954 - Class II aaRS ABD-related | 0 | Direct |
48452,48371
48452 - TPR-like
48371 - ARM repeat | 0 | Direct |
52540,50729
52540 - P-loop containing nucleoside triphosphate hydrolases
50729 - PH domain-like | 0 | Direct |
54511,57184
54511 - GFP-like
57184 - Growth factor receptor domain | 0 | Direct |
100895,100895
100895 - Kazal-type serine protease inhibitors
100895 - Kazal-type serine protease inhibitors | 0 | Direct |
56112,50729
56112 - Protein kinase-like (PK-like)
50729 - PH domain-like | 0 | Direct |
49785,53187
49785 - Galactose-binding domain-like
53187 - Zn-dependent exopeptidases | 0 | Direct |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0 | Direct |
48452,48403
48452 - TPR-like
48403 - Ankyrin repeat | 0 | Direct |
50156,50044
50156 - PDZ domain-like
50044 - SH3-domain | 0 | Direct |
53328,50486
53328 - Formyltransferase
50486 - FMT C-terminal domain-like | 0 | Direct |
49503,49503
49503 - Cupredoxins
49503 - Cupredoxins | 0 | Direct |
51419,50621
51419 - PLP-binding barrel
50621 - Alanine racemase C-terminal domain-like | 0 | Direct |
57667,140996
57667 - beta-beta-alpha zinc fingers
140996 - Hermes dimerisation domain | 0 | Direct |
52540,53254
52540 - P-loop containing nucleoside triphosphate hydrolases
53254 - Phosphoglycerate mutase-like | 0 | Direct |
55486,82895
55486 - Metalloproteases ("zincins"), catalytic domain
82895 - TSP-1 type 1 repeat | 0 | Direct |
55753,55753
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins | 0 | Direct |
50729,55550
50729 - PH domain-like
55550 - SH2 domain | 0 | Direct |
52374,47323
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
54534,54534
54534 - FKBP-like
54534 - FKBP-like | 0 | Direct |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.001724 | Inherited |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.002457 | Inherited |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.04001 | Inherited |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0.04508 | Inherited |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 0.05073 | Inherited |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0.05952 | Inherited |
47031,50729
47031 - Second domain of FERM
50729 - PH domain-like | 0.06232 | Inherited |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.06418 | Inherited |
54236,47031
54236 - Ubiquitin-like
47031 - Second domain of FERM | 0.0917 | Inherited |
81660,56784
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like | 0.1108 | Inherited |
57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.1137 | Inherited |
81296,81296
81296 - E set domains
81296 - E set domains | 0.127 | Inherited |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0.1417 | Inherited |
57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0.1572 | Inherited |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.1584 | Inherited |
52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.1765 | Inherited |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.2011 | Inherited |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0.2445 | Inherited |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0.2883 | Inherited |
54001,49758
54001 - Cysteine proteinases
49758 - Calpain large subunit, middle domain (domain III) | 0.3021 | Inherited |
57850,49599
57850 - RING/U-box
49599 - TRAF domain-like | 0.3021 | Inherited |
56784,81665
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.3696 | Inherited |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0.3717 | Inherited |
54236,54236
54236 - Ubiquitin-like
54236 - Ubiquitin-like | 0.3717 | Inherited |
49758,47473
49758 - Calpain large subunit, middle domain (domain III)
47473 - EF-hand | 0.4127 | Inherited |
55785,55785
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0.4127 | Inherited |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0.5065 | Inherited |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0.5065 | Inherited |
52777,52777
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases | 0.5065 | Inherited |
63411,63411
63411 - LuxS/MPP-like metallohydrolase
63411 - LuxS/MPP-like metallohydrolase | 0.5065 | Inherited |
47454,57959
47454 - A DNA-binding domain in eukaryotic transcription factors
57959 - Leucine zipper domain | 0.526 | Inherited |
54452,48726
54452 - MHC antigen-recognition domain
48726 - Immunoglobulin | 0.5578 | Inherited |
74788,75632
74788 - Cullin repeat-like
75632 - Cullin homology domain | 0.5632 | Inherited |
57535,49854
57535 - Complement control module/SCR domain
49854 - Spermadhesin, CUB domain | 0.5632 | Inherited |
81301,81631
81301 - Nucleotidyltransferase
81631 - PAP/OAS1 substrate-binding domain | 0.5643 | Inherited |
57889,57889
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0.5643 | Inherited |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.6444 | Inherited |
64593,64593
64593 - Intermediate filament protein, coiled coil region
64593 - Intermediate filament protein, coiled coil region | 0.6576 | Inherited |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0.6866 | Inherited |
103473,100895
103473 - MFS general substrate transporter
100895 - Kazal-type serine protease inhibitors | 0.6866 | Inherited |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0.6866 | Inherited |
52540,50447
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins | 0.7225 | Inherited |
46785,144074
46785 - "Winged helix" DNA-binding domain
144074 - E2F-DP heterodimerization region | 0.7716 | Inherited |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0.7824 | Inherited |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0.8501 | Inherited |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.9184 | Inherited |
46579,64593
46579 - Prefoldin
64593 - Intermediate filament protein, coiled coil region | 0.9336 | Inherited |
52518,52922
52518 - Thiamin diphosphate-binding fold (THDP-binding)
52922 - TK C-terminal domain-like | 0.9363 | Inherited |
49313,49313
49313 - Cadherin-like
49313 - Cadherin-like | 0.9566 | Inherited |
47986,52540
47986 - DEATH domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 1 | Inherited |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Jump to [ Top · Hierarchy ]
Supra-domain (Triple) in N- to C-terminal order( show details)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57196,57196,90193
57196 - EGF/Laminin
57196 - EGF/Laminin
90193 - Notch domain | 0 | DIRECT |
53067,100920,100934
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | DIRECT |
50156,52540,51045
50156 - PDZ domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
51045 - WW domain | 0 | DIRECT |
81995,81811,82754
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
81271,55186,55681
81271 - TGS-like
55186 - ThrRS/AlaRS common domain
55681 - Class II aaRS and biotin synthetases | 0 | DIRECT |
48726,56436,56436
48726 - Immunoglobulin
56436 - C-type lectin-like
56436 - C-type lectin-like | 0 | DIRECT |
51045,51045,56204
51045 - WW domain
51045 - WW domain
56204 - Hect, E3 ligase catalytic domain | 0 | DIRECT |
57184,57581,57184
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain | 0 | DIRECT |
63825,57196,63825
63825 - YWTD domain
57196 - EGF/Laminin
63825 - YWTD domain | 0 | DIRECT |
57603,57603,57603
57603 - FnI-like domain
57603 - FnI-like domain
57603 - FnI-like domain | 0 | DIRECT |
53738,53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | DIRECT |
57424,57424,57196
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57196 - EGF/Laminin | 0 | DIRECT |
49299,49299,49299
49299 - PKD domain
49299 - PKD domain
49299 - PKD domain | 0 | DIRECT |
50729,47473,51695
50729 - PH domain-like
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | DIRECT |
103657,50729,48350
103657 - BAR/IMD domain-like
50729 - PH domain-like
48350 - GTPase activation domain, GAP | 0 | DIRECT |
49785,57184,49265
49785 - Galactose-binding domain-like
57184 - Growth factor receptor domain
49265 - Fibronectin type III | 0 | DIRECT |
57581,57196,57581
57581 - TB module/8-cys domain
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0 | DIRECT |
82895,82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
47473,47473,57850
47473 - EF-hand
47473 - EF-hand
57850 - RING/U-box | 0 | DIRECT |
47473,47473,47473
47473 - EF-hand
47473 - EF-hand
47473 - EF-hand | 0 | DIRECT |
57424,57184,63825
57424 - LDL receptor-like module
57184 - Growth factor receptor domain
63825 - YWTD domain | 0 | DIRECT |
55753,55753,47050
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins
47050 - VHP, Villin headpiece domain | 0 | DIRECT |
47473,55550,57850
47473 - EF-hand
55550 - SH2 domain
57850 - RING/U-box | 0 | DIRECT |
57581,57196,57196
57581 - TB module/8-cys domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | DIRECT |
54928,54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0 | DIRECT |
53300,81995,81811
53300 - vWA-like
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24 | 0 | DIRECT |
53738,53738,55957
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | DIRECT |
63763,57903,47370
63763 - SAND domain-like
57903 - FYVE/PHD zinc finger
47370 - Bromodomain | 0 | DIRECT |
47769,47769,47769
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain | 0 | DIRECT |
57184,57196,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | DIRECT |
57850,48452,57850
57850 - RING/U-box
48452 - TPR-like
57850 - RING/U-box | 0 | DIRECT |
57196,57184,57196
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | DIRECT |
57196,57535,57535
57196 - EGF/Laminin
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | DIRECT |
56436,56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like
56436 - C-type lectin-like | 0 | DIRECT |
51045,47473,47473
51045 - WW domain
47473 - EF-hand
47473 - EF-hand | 0 | DIRECT |
49899,48726,49265
49899 - Concanavalin A-like lectins/glucanases
48726 - Immunoglobulin
49265 - Fibronectin type III | 0 | DIRECT |
57196,57196,63825
57196 - EGF/Laminin
57196 - EGF/Laminin
63825 - YWTD domain | 0 | DIRECT |
50156,50044,52540
50156 - PDZ domain-like
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
81698,81698,81698
81698 - FF domain
81698 - FF domain
81698 - FF domain | 0 | DIRECT |
63748,57903,57903
63748 - Tudor/PWWP/MBT
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0 | DIRECT |
57184,57184,57581
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain | 0 | DIRECT |
50044,50044,50044
50044 - SH3-domain
50044 - SH3-domain
50044 - SH3-domain | 0 | DIRECT |
54897,52743,49785
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | DIRECT |
56487,56487,56487
56487 - SRCR-like
56487 - SRCR-like
56487 - SRCR-like | 0 | DIRECT |
57889,57889,49562
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
90123,52540,90123
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0 | DIRECT |
57184,57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | DIRECT |
49854,57196,49854
49854 - Spermadhesin, CUB domain
57196 - EGF/Laminin
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
57850,49599,49599
57850 - RING/U-box
49599 - TRAF domain-like
49599 - TRAF domain-like | 0 | DIRECT |
57863,50729,50729
57863 - ArfGap/RecO-like zinc finger
50729 - PH domain-like
50729 - PH domain-like | 0 | DIRECT |
50447,-8,54980
50447 - Translation proteins
-8 - ECOD
54980 - EF-G C-terminal domain-like | 0 | DIRECT |
46565,57938,49493
46565 - Chaperone J-domain
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
50978,50978,50978
50978 - WD40 repeat-like
50978 - WD40 repeat-like
50978 - WD40 repeat-like | 0 | DIRECT |
54416,54416,49998
54416 - Amine oxidase N-terminal region
54416 - Amine oxidase N-terminal region
49998 - Amine oxidase catalytic domain | 0 | DIRECT |
103575,81296,81296
103575 - Plexin repeat
81296 - E set domains
81296 - E set domains | 0 | DIRECT |
52025,53187,47672
52025 - PA domain
53187 - Zn-dependent exopeptidases
47672 - Transferrin receptor-like dimerisation domain | 0 | DIRECT |
49785,53187,49464
49785 - Galactose-binding domain-like
53187 - Zn-dependent exopeptidases
49464 - Carboxypeptidase regulatory domain-like | 0 | DIRECT |
57938,49493,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | DIRECT |
82109,82109,100909
82109 - MIR domain
82109 - MIR domain
100909 - IP3 receptor type 1 binding core, domain 2 | 0 | DIRECT |
63737,55486,48371
63737 - Leukotriene A4 hydrolase N-terminal domain
55486 - Metalloproteases ("zincins"), catalytic domain
48371 - ARM repeat | 0 | DIRECT |
47459,55785,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0 | DIRECT |
100895,50494,50156
100895 - Kazal-type serine protease inhibitors
50494 - Trypsin-like serine proteases
50156 - PDZ domain-like | 0 | DIRECT |
52540,90123,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
49265,48726,49265
49265 - Fibronectin type III
48726 - Immunoglobulin
49265 - Fibronectin type III | 0 | DIRECT |
48371,56112,64268
48371 - ARM repeat
56112 - Protein kinase-like (PK-like)
64268 - PX domain | 0 | DIRECT |
57535,57535,50494
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
50494 - Trypsin-like serine proteases | 0 | DIRECT |
90229,90229,90229
90229 - CCCH zinc finger
90229 - CCCH zinc finger
90229 - CCCH zinc finger | 0 | DIRECT |
49899,57424,49899
49899 - Concanavalin A-like lectins/glucanases
57424 - LDL receptor-like module
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
48726,82895,82895
48726 - Immunoglobulin
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
141072,141072,141072
141072 - CalX-like
141072 - CalX-like
141072 - CalX-like | 0 | DIRECT |
57196,57184,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | DIRECT |
48366,47473,57889
48366 - Ras GEF
47473 - EF-hand
57889 - Cysteine-rich domain | 0 | DIRECT |
47668,47473,55550
47668 - N-terminal domain of cbl (N-cbl)
47473 - EF-hand
55550 - SH2 domain | 0 | DIRECT |
81296,81296,81296
81296 - E set domains
81296 - E set domains
81296 - E set domains | 0 | DIRECT |
82754,55753,55753
82754 - C-terminal, gelsolin-like domain of Sec23/24
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins | 0 | DIRECT |
46966,51045,47473
46966 - Spectrin repeat
51045 - WW domain
47473 - EF-hand | 0 | DIRECT |
117018,56091,50249
117018 - ATP-dependent DNA ligase DNA-binding domain
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
57184,57196,57184
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | DIRECT |
50370,57440,56436
50370 - Ricin B-like lectins
57440 - Kringle-like
56436 - C-type lectin-like | 0 | DIRECT |
48726,48726,82895
48726 - Immunoglobulin
48726 - Immunoglobulin
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
49503,49503,49503
49503 - Cupredoxins
49503 - Cupredoxins
49503 - Cupredoxins | 0 | DIRECT |
55486,49854,49854
55486 - Metalloproteases ("zincins"), catalytic domain
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
63748,82199,57903
63748 - Tudor/PWWP/MBT
82199 - SET domain
57903 - FYVE/PHD zinc finger | 0 | DIRECT |
57184,57581,57196
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0 | DIRECT |
100895,47473,57610
100895 - Kazal-type serine protease inhibitors
47473 - EF-hand
57610 - Thyroglobulin type-1 domain | 0 | DIRECT |
50249,50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | DIRECT |
57196,57581,57196
57196 - EGF/Laminin
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0 | DIRECT |
57184,57184,57196
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | DIRECT |
52540,52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
103647,103647,103647
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat | 0 | DIRECT |
50729,55550,56112
50729 - PH domain-like
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
56112,64268,49562
56112 - Protein kinase-like (PK-like)
64268 - PX domain
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
57196,49854,57535
57196 - EGF/Laminin
49854 - Spermadhesin, CUB domain
57535 - Complement control module/SCR domain | 0 | DIRECT |
49899,57196,57196
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | DIRECT |
101912,103575,48726
101912 - Sema domain
103575 - Plexin repeat
48726 - Immunoglobulin | 0 | DIRECT |
57414,57440,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like
57440 - Kringle-like | 0 | DIRECT |
50044,48065,50729
50044 - SH3-domain
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0 | DIRECT |
52540,51045,51045
52540 - P-loop containing nucleoside triphosphate hydrolases
51045 - WW domain
51045 - WW domain | 0 | DIRECT |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
57184,100895,50494
57184 - Growth factor receptor domain
100895 - Kazal-type serine protease inhibitors
50494 - Trypsin-like serine proteases | 0 | DIRECT |
48552,48552,48552
48552 - Serum albumin-like
48552 - Serum albumin-like
48552 - Serum albumin-like | 0 | DIRECT |
57196,57581,57184
57196 - EGF/Laminin
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain | 0 | DIRECT |
63825,57196,57424
63825 - YWTD domain
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0 | DIRECT |
74650,51445,51011
74650 - Galactose mutarotase-like
51445 - (Trans)glycosidases
51011 - Glycosyl hydrolase domain | 0 | DIRECT |
51045,51045,51045
51045 - WW domain
51045 - WW domain
51045 - WW domain | 0 | DIRECT |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | DIRECT |
50729,50156,50156
50729 - PH domain-like
50156 - PDZ domain-like
50156 - PDZ domain-like | 0 | DIRECT |
52440,56059,51246
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0 | DIRECT |
57196,49899,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
57196,57196,69687
57196 - EGF/Laminin
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0 | DIRECT |
82185,82185,82185
82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 0 | DIRECT |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
57581,57184,57184
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | DIRECT |
57196,57196,57581
57196 - EGF/Laminin
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0 | DIRECT |
46585,46585,46585
46585 - HR1 repeat
46585 - HR1 repeat
46585 - HR1 repeat | 0 | DIRECT |
57424,57196,57196
57424 - LDL receptor-like module
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | DIRECT |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | DIRECT |
101288,50156,50044
101288 - L27 domain
50156 - PDZ domain-like
50044 - SH3-domain | 0 | DIRECT |
90188,90188,53649
90188 - Somatomedin B domain
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like | 0 | DIRECT |
55186,55681,52954
55186 - ThrRS/AlaRS common domain
55681 - Class II aaRS and biotin synthetases
52954 - Class II aaRS ABD-related | 0 | DIRECT |
47473,47473,57889
47473 - EF-hand
47473 - EF-hand
57889 - Cysteine-rich domain | 0 | DIRECT |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | DIRECT |
50044,55550,50044
50044 - SH3-domain
55550 - SH2 domain
50044 - SH3-domain | 0 | DIRECT |
49265,49265,53300
49265 - Fibronectin type III
49265 - Fibronectin type III
53300 - vWA-like | 0 | DIRECT |
142921,47587,56399
142921 - WGR domain-like
47587 - Domain of poly(ADP-ribose) polymerase
56399 - ADP-ribosylation | 0 | DIRECT |
57492,74650,51445
57492 - Trefoil
74650 - Galactose mutarotase-like
51445 - (Trans)glycosidases | 0 | DIRECT |
50129,51735,50129
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains
50129 - GroES-like | 0 | DIRECT |
46966,46966,51045
46966 - Spectrin repeat
46966 - Spectrin repeat
51045 - WW domain | 0 | DIRECT |
57630,57196,50494
57630 - GLA-domain
57196 - EGF/Laminin
50494 - Trypsin-like serine proteases | 0 | DIRECT |
103647,103647,49899
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
55753,55753,55753
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins | 0 | DIRECT |
63748,63748,63748
63748 - Tudor/PWWP/MBT
63748 - Tudor/PWWP/MBT
63748 - Tudor/PWWP/MBT | 0 | DIRECT |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
50729,50729,48350
50729 - PH domain-like
50729 - PH domain-like
48350 - GTPase activation domain, GAP | 0 | DIRECT |
49899,49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
48065,50729,50044
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like
50044 - SH3-domain | 0 | DIRECT |
49313,49313,49899
49313 - Cadherin-like
49313 - Cadherin-like
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
47576,48065,50729
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0 | DIRECT |
57184,57581,57581
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain
57581 - TB module/8-cys domain | 0 | DIRECT |
57196,49854,49854
57196 - EGF/Laminin
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
47220,47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | DIRECT |
47986,47986,52129
47986 - DEATH domain
47986 - DEATH domain
52129 - Caspase-like | 0 | DIRECT |
57424,57424,57184
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57184 - Growth factor receptor domain | 0 | DIRECT |
53067,53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0 | DIRECT |
54160,52540,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
57440,57440,50494
57440 - Kringle-like
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0 | DIRECT |
53300,53300,53300
53300 - vWA-like
53300 - vWA-like
53300 - vWA-like | 0 | DIRECT |
52058,48726,48726
52058 - L domain-like
48726 - Immunoglobulin
48726 - Immunoglobulin | 0 | DIRECT |
46966,46966,47473
46966 - Spectrin repeat
46966 - Spectrin repeat
47473 - EF-hand | 0 | DIRECT |
47473,57889,57889
47473 - EF-hand
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0 | DIRECT |
57196,57424,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | DIRECT |
52743,49785,57184
52743 - Subtilisin-like
49785 - Galactose-binding domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
49899,57196,49899
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
69179,69179,69179
69179 - Integrin domains
69179 - Integrin domains
69179 - Integrin domains | 0 | DIRECT |
100895,100895,100895
100895 - Kazal-type serine protease inhibitors
100895 - Kazal-type serine protease inhibitors
100895 - Kazal-type serine protease inhibitors | 0 | DIRECT |
57586,57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like
57586 - TNF receptor-like | 0 | DIRECT |
57924,57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | DIRECT |
57196,63825,57196
57196 - EGF/Laminin
63825 - YWTD domain
57196 - EGF/Laminin | 0 | DIRECT |
50729,50729,57863
50729 - PH domain-like
50729 - PH domain-like
57863 - ArfGap/RecO-like zinc finger | 0 | DIRECT |
55550,56112,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
69318,69179,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains
69179 - Integrin domains | 0 | DIRECT |
57184,100895,48726
57184 - Growth factor receptor domain
100895 - Kazal-type serine protease inhibitors
48726 - Immunoglobulin | 0 | DIRECT |
82754,82754,55753
82754 - C-terminal, gelsolin-like domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24
55753 - Actin depolymerizing proteins | 0 | DIRECT |
48726,49265,56112
48726 - Immunoglobulin
49265 - Fibronectin type III
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
49503,110083,55909
49503 - Cupredoxins
110083 - Peptidylarginine deiminase Pad4, middle domain
55909 - Pentein | 0 | DIRECT |
54160,54160,52540
54160 - Chromo domain-like
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
57440,56436,56436
57440 - Kringle-like
56436 - C-type lectin-like
56436 - C-type lectin-like | 0 | DIRECT |
57196,57184,49899
57196 - EGF/Laminin
57184 - Growth factor receptor domain
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
49562,57889,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0 | DIRECT |
56645,47203,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | DIRECT |
48452,57850,88697
48452 - TPR-like
57850 - RING/U-box
88697 - PUA domain-like | 0 | DIRECT |
54768,54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 0 | DIRECT |
103637,103637,103637
103637 - CCHHC domain
103637 - CCHHC domain
103637 - CCHHC domain | 0 | DIRECT |
57184,49899,49899
57184 - Growth factor receptor domain
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
57581,57184,57581
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain | 0 | DIRECT |
53300,69318,69179
53300 - vWA-like
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0 | DIRECT |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0 | DIRECT |
52540,52540,46785
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
49265,48726,48726
49265 - Fibronectin type III
48726 - Immunoglobulin
48726 - Immunoglobulin | 0 | DIRECT |
55753,82754,82754
55753 - Actin depolymerizing proteins
82754 - C-terminal, gelsolin-like domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
48065,50729,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like
50729 - PH domain-like | 0 | DIRECT |
51230,47005,52777
51230 - Single hybrid motif
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
52777 - CoA-dependent acyltransferases | 0 | DIRECT |
46689,46689,46689
46689 - Homeodomain-like
46689 - Homeodomain-like
46689 - Homeodomain-like | 0 | DIRECT |
50729,81837,50978
50729 - PH domain-like
81837 - BEACH domain
50978 - WD40 repeat-like | 0 | DIRECT |
54791,54791,54791
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | DIRECT |
57903,63748,82199
57903 - FYVE/PHD zinc finger
63748 - Tudor/PWWP/MBT
82199 - SET domain | 0 | DIRECT |
54236,47031,50729
54236 - Ubiquitin-like
47031 - Second domain of FERM
50729 - PH domain-like | 0.0917 | INHERITED FROM: Benzopyrenes |
81660,56784,81665
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.1108 | INHERITED FROM: Cardenolides || Strophanthins || Cardiac Glycosides || Ouabain || Cardanolides |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.1417 | INHERITED FROM: Tretinoin || Vitamin A |
50044,55550,56112
50044 - SH3-domain
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.1417 | INHERITED FROM: tamibarotene |
57424,57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.1584 | INHERITED FROM: tanshinone |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.1969 | INHERITED FROM: Anthracenes || cobaltiprotoporphyrin || Tetracyclines || Simvastatin || Mifepristone || Lovastatin || Tetrapyrroles || Paclitaxel || manganese(III)-tetrakis(4-benzoic acid)porphyrin || pyrazolanthrone || Metalloporphyrins || Doxycycline || Tetracycline || Estradiol |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.2132 | INHERITED FROM: Benzopyrenes |
52833,52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.2199 | INHERITED FROM: Androstanols || Sesquiterpenes, Guaiane || Cycloheptanes || Sesquiterpenes, Eudesmane || Dihydrotestosterone || Thapsigargin || Polycyclic Sesquiterpenes |
57535,57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0.3696 | INHERITED FROM: Norgestrel || Cholic Acids || 1-Naphthylisothiocyanate |
54001,49758,47473
54001 - Cysteine proteinases
49758 - Calpain large subunit, middle domain (domain III)
47473 - EF-hand | 0.4582 | INHERITED FROM: Menthol || Cyclohexanols || Cyclohexane Monoterpenes |
57440,57440,57440
57440 - Kringle-like
57440 - Kringle-like
57440 - Kringle-like | 0.5065 | INHERITED FROM: Cholic Acids || Taurocholic Acid || Simvastatin || Medroxyprogesterone || Medroxyprogesterone Acetate || Cholanes || Bile Acids and Salts || Isotretinoin |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0.5065 | INHERITED FROM: Indenes || Polyketides || Podophyllotoxin || Anthracenes || Fulvestrant || sulindac sulfide || Paclitaxel || Cyclopentanes || Epirubicin || Tetrahydronaphthalenes || Sulindac || Mitoxantrone || Cyclodecanes || Etoposide |
49854,57535,49854
49854 - Spermadhesin, CUB domain
57535 - Complement control module/SCR domain
49854 - Spermadhesin, CUB domain | 0.5632 | INHERITED FROM: benzo(e)pyrene |
74788,75632,46785
74788 - Cullin repeat-like
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0.5632 | INHERITED FROM: Dihydroxydihydrobenzopyrenes || 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
57535,49854,57535
57535 - Complement control module/SCR domain
49854 - Spermadhesin, CUB domain
57535 - Complement control module/SCR domain | 0.5632 | INHERITED FROM: benzo(e)pyrene |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.6866 | INHERITED FROM: Adamantane || Bridged-Ring Compounds || Ivermectin || CD 437 || Okadaic Acid || 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid |
49313,49313,49313
49313 - Cadherin-like
49313 - Cadherin-like
49313 - Cadherin-like | 0.9709 | INHERITED FROM: jasplakinolide || dibenzo(a,l)pyrene |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.9782 | INHERITED FROM: 5H-benzo(4,5)cyclohepta(1,2-b)pyridin-5-one |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
57196,57196,90193
57196 - EGF/Laminin
57196 - EGF/Laminin
90193 - Notch domain | 0 | Direct |
53067,100920,100934
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0 | Direct |
50156,52540,51045
50156 - PDZ domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
51045 - WW domain | 0 | Direct |
81995,81811,82754
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
81271,55186,55681
81271 - TGS-like
55186 - ThrRS/AlaRS common domain
55681 - Class II aaRS and biotin synthetases | 0 | Direct |
48726,56436,56436
48726 - Immunoglobulin
56436 - C-type lectin-like
56436 - C-type lectin-like | 0 | Direct |
51045,51045,56204
51045 - WW domain
51045 - WW domain
56204 - Hect, E3 ligase catalytic domain | 0 | Direct |
57184,57581,57184
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain | 0 | Direct |
63825,57196,63825
63825 - YWTD domain
57196 - EGF/Laminin
63825 - YWTD domain | 0 | Direct |
57603,57603,57603
57603 - FnI-like domain
57603 - FnI-like domain
57603 - FnI-like domain | 0 | Direct |
53738,53738,53738
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains | 0 | Direct |
57424,57424,57196
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57196 - EGF/Laminin | 0 | Direct |
49299,49299,49299
49299 - PKD domain
49299 - PKD domain
49299 - PKD domain | 0 | Direct |
50729,47473,51695
50729 - PH domain-like
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | Direct |
103657,50729,48350
103657 - BAR/IMD domain-like
50729 - PH domain-like
48350 - GTPase activation domain, GAP | 0 | Direct |
49785,57184,49265
49785 - Galactose-binding domain-like
57184 - Growth factor receptor domain
49265 - Fibronectin type III | 0 | Direct |
57581,57196,57581
57581 - TB module/8-cys domain
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0 | Direct |
82895,82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | Direct |
47473,47473,57850
47473 - EF-hand
47473 - EF-hand
57850 - RING/U-box | 0 | Direct |
47473,47473,47473
47473 - EF-hand
47473 - EF-hand
47473 - EF-hand | 0 | Direct |
57424,57184,63825
57424 - LDL receptor-like module
57184 - Growth factor receptor domain
63825 - YWTD domain | 0 | Direct |
55753,55753,47050
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins
47050 - VHP, Villin headpiece domain | 0 | Direct |
47473,55550,57850
47473 - EF-hand
55550 - SH2 domain
57850 - RING/U-box | 0 | Direct |
57581,57196,57196
57581 - TB module/8-cys domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | Direct |
54928,54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0 | Direct |
53300,81995,81811
53300 - vWA-like
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24 | 0 | Direct |
53738,53738,55957
53738 - Phosphoglucomutase, first 3 domains
53738 - Phosphoglucomutase, first 3 domains
55957 - Phosphoglucomutase, C-terminal domain | 0 | Direct |
63763,57903,47370
63763 - SAND domain-like
57903 - FYVE/PHD zinc finger
47370 - Bromodomain | 0 | Direct |
47769,47769,47769
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain
47769 - SAM/Pointed domain | 0 | Direct |
57184,57196,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | Direct |
57850,48452,57850
57850 - RING/U-box
48452 - TPR-like
57850 - RING/U-box | 0 | Direct |
57196,57184,57196
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | Direct |
57196,57535,57535
57196 - EGF/Laminin
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0 | Direct |
56436,56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like
56436 - C-type lectin-like | 0 | Direct |
51045,47473,47473
51045 - WW domain
47473 - EF-hand
47473 - EF-hand | 0 | Direct |
49899,48726,49265
49899 - Concanavalin A-like lectins/glucanases
48726 - Immunoglobulin
49265 - Fibronectin type III | 0 | Direct |
57196,57196,63825
57196 - EGF/Laminin
57196 - EGF/Laminin
63825 - YWTD domain | 0 | Direct |
50156,50044,52540
50156 - PDZ domain-like
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
81698,81698,81698
81698 - FF domain
81698 - FF domain
81698 - FF domain | 0 | Direct |
63748,57903,57903
63748 - Tudor/PWWP/MBT
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0 | Direct |
57184,57184,57581
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain | 0 | Direct |
50044,50044,50044
50044 - SH3-domain
50044 - SH3-domain
50044 - SH3-domain | 0 | Direct |
54897,52743,49785
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | Direct |
56487,56487,56487
56487 - SRCR-like
56487 - SRCR-like
56487 - SRCR-like | 0 | Direct |
57889,57889,49562
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
90123,52540,90123
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region | 0 | Direct |
57184,57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | Direct |
49854,57196,49854
49854 - Spermadhesin, CUB domain
57196 - EGF/Laminin
49854 - Spermadhesin, CUB domain | 0 | Direct |
57850,49599,49599
57850 - RING/U-box
49599 - TRAF domain-like
49599 - TRAF domain-like | 0 | Direct |
57863,50729,50729
57863 - ArfGap/RecO-like zinc finger
50729 - PH domain-like
50729 - PH domain-like | 0 | Direct |
50447,-8,54980
50447 - Translation proteins
-8 - ECOD
54980 - EF-G C-terminal domain-like | 0 | Direct |
46565,57938,49493
46565 - Chaperone J-domain
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
50978,50978,50978
50978 - WD40 repeat-like
50978 - WD40 repeat-like
50978 - WD40 repeat-like | 0 | Direct |
54416,54416,49998
54416 - Amine oxidase N-terminal region
54416 - Amine oxidase N-terminal region
49998 - Amine oxidase catalytic domain | 0 | Direct |
103575,81296,81296
103575 - Plexin repeat
81296 - E set domains
81296 - E set domains | 0 | Direct |
52025,53187,47672
52025 - PA domain
53187 - Zn-dependent exopeptidases
47672 - Transferrin receptor-like dimerisation domain | 0 | Direct |
49785,53187,49464
49785 - Galactose-binding domain-like
53187 - Zn-dependent exopeptidases
49464 - Carboxypeptidase regulatory domain-like | 0 | Direct |
57938,49493,49493
57938 - DnaJ/Hsp40 cysteine-rich domain
49493 - HSP40/DnaJ peptide-binding domain
49493 - HSP40/DnaJ peptide-binding domain | 0 | Direct |
82109,82109,100909
82109 - MIR domain
82109 - MIR domain
100909 - IP3 receptor type 1 binding core, domain 2 | 0 | Direct |
63737,55486,48371
63737 - Leukotriene A4 hydrolase N-terminal domain
55486 - Metalloproteases ("zincins"), catalytic domain
48371 - ARM repeat | 0 | Direct |
47459,55785,55785
47459 - HLH, helix-loop-helix DNA-binding domain
55785 - PYP-like sensor domain (PAS domain)
55785 - PYP-like sensor domain (PAS domain) | 0 | Direct |
100895,50494,50156
100895 - Kazal-type serine protease inhibitors
50494 - Trypsin-like serine proteases
50156 - PDZ domain-like | 0 | Direct |
52540,90123,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
49265,48726,49265
49265 - Fibronectin type III
48726 - Immunoglobulin
49265 - Fibronectin type III | 0 | Direct |
48371,56112,64268
48371 - ARM repeat
56112 - Protein kinase-like (PK-like)
64268 - PX domain | 0 | Direct |
57535,57535,50494
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
50494 - Trypsin-like serine proteases | 0 | Direct |
90229,90229,90229
90229 - CCCH zinc finger
90229 - CCCH zinc finger
90229 - CCCH zinc finger | 0 | Direct |
49899,57424,49899
49899 - Concanavalin A-like lectins/glucanases
57424 - LDL receptor-like module
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
48726,82895,82895
48726 - Immunoglobulin
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | Direct |
141072,141072,141072
141072 - CalX-like
141072 - CalX-like
141072 - CalX-like | 0 | Direct |
57196,57184,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | Direct |
48366,47473,57889
48366 - Ras GEF
47473 - EF-hand
57889 - Cysteine-rich domain | 0 | Direct |
47668,47473,55550
47668 - N-terminal domain of cbl (N-cbl)
47473 - EF-hand
55550 - SH2 domain | 0 | Direct |
81296,81296,81296
81296 - E set domains
81296 - E set domains
81296 - E set domains | 0 | Direct |
82754,55753,55753
82754 - C-terminal, gelsolin-like domain of Sec23/24
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins | 0 | Direct |
46966,51045,47473
46966 - Spectrin repeat
51045 - WW domain
47473 - EF-hand | 0 | Direct |
117018,56091,50249
117018 - ATP-dependent DNA ligase DNA-binding domain
56091 - DNA ligase/mRNA capping enzyme, catalytic domain
50249 - Nucleic acid-binding proteins | 0 | Direct |
57184,57196,57184
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | Direct |
50370,57440,56436
50370 - Ricin B-like lectins
57440 - Kringle-like
56436 - C-type lectin-like | 0 | Direct |
48726,48726,82895
48726 - Immunoglobulin
48726 - Immunoglobulin
82895 - TSP-1 type 1 repeat | 0 | Direct |
49503,49503,49503
49503 - Cupredoxins
49503 - Cupredoxins
49503 - Cupredoxins | 0 | Direct |
55486,49854,49854
55486 - Metalloproteases ("zincins"), catalytic domain
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain | 0 | Direct |
63748,82199,57903
63748 - Tudor/PWWP/MBT
82199 - SET domain
57903 - FYVE/PHD zinc finger | 0 | Direct |
57184,57581,57196
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0 | Direct |
100895,47473,57610
100895 - Kazal-type serine protease inhibitors
47473 - EF-hand
57610 - Thyroglobulin type-1 domain | 0 | Direct |
50249,50249,50249
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins
50249 - Nucleic acid-binding proteins | 0 | Direct |
57196,57581,57196
57196 - EGF/Laminin
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0 | Direct |
57184,57184,57196
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | Direct |
52540,52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
103647,103647,103647
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat | 0 | Direct |
50729,55550,56112
50729 - PH domain-like
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | Direct |
56112,64268,49562
56112 - Protein kinase-like (PK-like)
64268 - PX domain
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
57196,49854,57535
57196 - EGF/Laminin
49854 - Spermadhesin, CUB domain
57535 - Complement control module/SCR domain | 0 | Direct |
49899,57196,57196
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | Direct |
101912,103575,48726
101912 - Sema domain
103575 - Plexin repeat
48726 - Immunoglobulin | 0 | Direct |
57414,57440,57440
57414 - Hairpin loop containing domain-like
57440 - Kringle-like
57440 - Kringle-like | 0 | Direct |
50044,48065,50729
50044 - SH3-domain
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0 | Direct |
52540,51045,51045
52540 - P-loop containing nucleoside triphosphate hydrolases
51045 - WW domain
51045 - WW domain | 0 | Direct |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | Direct |
57184,100895,50494
57184 - Growth factor receptor domain
100895 - Kazal-type serine protease inhibitors
50494 - Trypsin-like serine proteases | 0 | Direct |
48552,48552,48552
48552 - Serum albumin-like
48552 - Serum albumin-like
48552 - Serum albumin-like | 0 | Direct |
57196,57581,57184
57196 - EGF/Laminin
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain | 0 | Direct |
63825,57196,57424
63825 - YWTD domain
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0 | Direct |
74650,51445,51011
74650 - Galactose mutarotase-like
51445 - (Trans)glycosidases
51011 - Glycosyl hydrolase domain | 0 | Direct |
51045,51045,51045
51045 - WW domain
51045 - WW domain
51045 - WW domain | 0 | Direct |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | Direct |
50729,50156,50156
50729 - PH domain-like
50156 - PDZ domain-like
50156 - PDZ domain-like | 0 | Direct |
52440,56059,51246
52440 - PreATP-grasp domain
56059 - Glutathione synthetase ATP-binding domain-like
51246 - Rudiment single hybrid motif | 0 | Direct |
57196,49899,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
57196,57196,69687
57196 - EGF/Laminin
57196 - EGF/Laminin
69687 - Integrin beta tail domain | 0 | Direct |
82185,82185,82185
82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 0 | Direct |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | Direct |
57581,57184,57184
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | Direct |
57196,57196,57581
57196 - EGF/Laminin
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0 | Direct |
46585,46585,46585
46585 - HR1 repeat
46585 - HR1 repeat
46585 - HR1 repeat | 0 | Direct |
57424,57196,57196
57424 - LDL receptor-like module
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | Direct |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | Direct |
101288,50156,50044
101288 - L27 domain
50156 - PDZ domain-like
50044 - SH3-domain | 0 | Direct |
90188,90188,53649
90188 - Somatomedin B domain
90188 - Somatomedin B domain
53649 - Alkaline phosphatase-like | 0 | Direct |
55186,55681,52954
55186 - ThrRS/AlaRS common domain
55681 - Class II aaRS and biotin synthetases
52954 - Class II aaRS ABD-related | 0 | Direct |
47473,47473,57889
47473 - EF-hand
47473 - EF-hand
57889 - Cysteine-rich domain | 0 | Direct |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | Direct |
50044,55550,50044
50044 - SH3-domain
55550 - SH2 domain
50044 - SH3-domain | 0 | Direct |
49265,49265,53300
49265 - Fibronectin type III
49265 - Fibronectin type III
53300 - vWA-like | 0 | Direct |
142921,47587,56399
142921 - WGR domain-like
47587 - Domain of poly(ADP-ribose) polymerase
56399 - ADP-ribosylation | 0 | Direct |
57492,74650,51445
57492 - Trefoil
74650 - Galactose mutarotase-like
51445 - (Trans)glycosidases | 0 | Direct |
50129,51735,50129
50129 - GroES-like
51735 - NAD(P)-binding Rossmann-fold domains
50129 - GroES-like | 0 | Direct |
46966,46966,51045
46966 - Spectrin repeat
46966 - Spectrin repeat
51045 - WW domain | 0 | Direct |
57630,57196,50494
57630 - GLA-domain
57196 - EGF/Laminin
50494 - Trypsin-like serine proteases | 0 | Direct |
103647,103647,49899
103647 - TSP type-3 repeat
103647 - TSP type-3 repeat
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
55753,55753,55753
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins | 0 | Direct |
63748,63748,63748
63748 - Tudor/PWWP/MBT
63748 - Tudor/PWWP/MBT
63748 - Tudor/PWWP/MBT | 0 | Direct |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
50729,50729,48350
50729 - PH domain-like
50729 - PH domain-like
48350 - GTPase activation domain, GAP | 0 | Direct |
49899,49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
48065,50729,50044
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like
50044 - SH3-domain | 0 | Direct |
49313,49313,49899
49313 - Cadherin-like
49313 - Cadherin-like
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
47576,48065,50729
47576 - Calponin-homology domain, CH-domain
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0 | Direct |
57184,57581,57581
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain
57581 - TB module/8-cys domain | 0 | Direct |
57196,49854,49854
57196 - EGF/Laminin
49854 - Spermadhesin, CUB domain
49854 - Spermadhesin, CUB domain | 0 | Direct |
47220,47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0 | Direct |
47986,47986,52129
47986 - DEATH domain
47986 - DEATH domain
52129 - Caspase-like | 0 | Direct |
57424,57424,57184
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57184 - Growth factor receptor domain | 0 | Direct |
53067,53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0 | Direct |
54160,52540,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
57440,57440,50494
57440 - Kringle-like
57440 - Kringle-like
50494 - Trypsin-like serine proteases | 0 | Direct |
53300,53300,53300
53300 - vWA-like
53300 - vWA-like
53300 - vWA-like | 0 | Direct |
52058,48726,48726
52058 - L domain-like
48726 - Immunoglobulin
48726 - Immunoglobulin | 0 | Direct |
46966,46966,47473
46966 - Spectrin repeat
46966 - Spectrin repeat
47473 - EF-hand | 0 | Direct |
47473,57889,57889
47473 - EF-hand
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0 | Direct |
57196,57424,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | Direct |
52743,49785,57184
52743 - Subtilisin-like
49785 - Galactose-binding domain-like
57184 - Growth factor receptor domain | 0 | Direct |
49899,57196,49899
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
69179,69179,69179
69179 - Integrin domains
69179 - Integrin domains
69179 - Integrin domains | 0 | Direct |
100895,100895,100895
100895 - Kazal-type serine protease inhibitors
100895 - Kazal-type serine protease inhibitors
100895 - Kazal-type serine protease inhibitors | 0 | Direct |
57586,57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like
57586 - TNF receptor-like | 0 | Direct |
57924,57924,57924
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat
57924 - Inhibitor of apoptosis (IAP) repeat | 0 | Direct |
57196,63825,57196
57196 - EGF/Laminin
63825 - YWTD domain
57196 - EGF/Laminin | 0 | Direct |
50729,50729,57863
50729 - PH domain-like
50729 - PH domain-like
57863 - ArfGap/RecO-like zinc finger | 0 | Direct |
55550,56112,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0 | Direct |
69318,69179,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains
69179 - Integrin domains | 0 | Direct |
57184,100895,48726
57184 - Growth factor receptor domain
100895 - Kazal-type serine protease inhibitors
48726 - Immunoglobulin | 0 | Direct |
82754,82754,55753
82754 - C-terminal, gelsolin-like domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24
55753 - Actin depolymerizing proteins | 0 | Direct |
48726,49265,56112
48726 - Immunoglobulin
49265 - Fibronectin type III
56112 - Protein kinase-like (PK-like) | 0 | Direct |
49503,110083,55909
49503 - Cupredoxins
110083 - Peptidylarginine deiminase Pad4, middle domain
55909 - Pentein | 0 | Direct |
54160,54160,52540
54160 - Chromo domain-like
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
57440,56436,56436
57440 - Kringle-like
56436 - C-type lectin-like
56436 - C-type lectin-like | 0 | Direct |
57196,57184,49899
57196 - EGF/Laminin
57184 - Growth factor receptor domain
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
49562,57889,57889
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
57889 - Cysteine-rich domain
57889 - Cysteine-rich domain | 0 | Direct |
56645,47203,47203
56645 - Acyl-CoA dehydrogenase NM domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
47203 - Acyl-CoA dehydrogenase C-terminal domain-like | 0 | Direct |
48452,57850,88697
48452 - TPR-like
57850 - RING/U-box
88697 - PUA domain-like | 0 | Direct |
54768,54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 0 | Direct |
103637,103637,103637
103637 - CCHHC domain
103637 - CCHHC domain
103637 - CCHHC domain | 0 | Direct |
57184,49899,49899
57184 - Growth factor receptor domain
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
57581,57184,57581
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain | 0 | Direct |
53300,69318,69179
53300 - vWA-like
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0 | Direct |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0 | Direct |
52540,52540,46785
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
49265,48726,48726
49265 - Fibronectin type III
48726 - Immunoglobulin
48726 - Immunoglobulin | 0 | Direct |
55753,82754,82754
55753 - Actin depolymerizing proteins
82754 - C-terminal, gelsolin-like domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
48065,50729,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like
50729 - PH domain-like | 0 | Direct |
51230,47005,52777
51230 - Single hybrid motif
47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
52777 - CoA-dependent acyltransferases | 0 | Direct |
46689,46689,46689
46689 - Homeodomain-like
46689 - Homeodomain-like
46689 - Homeodomain-like | 0 | Direct |
50729,81837,50978
50729 - PH domain-like
81837 - BEACH domain
50978 - WD40 repeat-like | 0 | Direct |
54791,54791,54791
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | Direct |
57903,63748,82199
57903 - FYVE/PHD zinc finger
63748 - Tudor/PWWP/MBT
82199 - SET domain | 0 | Direct |
54236,47031,50729
54236 - Ubiquitin-like
47031 - Second domain of FERM
50729 - PH domain-like | 0.0917 | Inherited |
81660,56784,81665
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0.1108 | Inherited |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 0.1417 | Inherited |
50044,55550,56112
50044 - SH3-domain
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.1417 | Inherited |
57424,57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.1584 | Inherited |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0.1969 | Inherited |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.2132 | Inherited |
52833,52833,52833
52833 - Thioredoxin-like
52833 - Thioredoxin-like
52833 - Thioredoxin-like | 0.2199 | Inherited |
57535,57535,57535
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain
57535 - Complement control module/SCR domain | 0.3696 | Inherited |
54001,49758,47473
54001 - Cysteine proteinases
49758 - Calpain large subunit, middle domain (domain III)
47473 - EF-hand | 0.4582 | Inherited |
57440,57440,57440
57440 - Kringle-like
57440 - Kringle-like
57440 - Kringle-like | 0.5065 | Inherited |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0.5065 | Inherited |
49854,57535,49854
49854 - Spermadhesin, CUB domain
57535 - Complement control module/SCR domain
49854 - Spermadhesin, CUB domain | 0.5632 | Inherited |
74788,75632,46785
74788 - Cullin repeat-like
75632 - Cullin homology domain
46785 - "Winged helix" DNA-binding domain | 0.5632 | Inherited |
57535,49854,57535
57535 - Complement control module/SCR domain
49854 - Spermadhesin, CUB domain
57535 - Complement control module/SCR domain | 0.5632 | Inherited |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.6866 | Inherited |
49313,49313,49313
49313 - Cadherin-like
49313 - Cadherin-like
49313 - Cadherin-like | 0.9709 | Inherited |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.9782 | Inherited |
LINKTO: Supra-domain2BO Download and Supra-domain2BO Algorithm
Plot distribution on species Tree Of Life (sTOL) for Superfamily and/or Family domains annotated by this CC term
 |
Plot tree as:
| |
Download Newick format tree:
|
( show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Plot distribution on species Tree Of Life (sTOL) for single supra-domains annotated by this CC term
|
Plot tree as:
| |
Download Newick format tree:
| |
Browsing in TREE OF LIFE:
|
( show help)
Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
|
|
> BO Hierarchy > Polycyclic Compounds
