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Tubulin, GTPase domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Tubulin nucleotide-binding domain-like [ 52489]
Superfamily:   Tubulin nucleotide-binding domain-like [ 52490]
Family:   Tubulin, GTPase domain [ 52491] (3)

Family statistics
Genomes (3,001) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 9,552 67,153 19
Proteins 9,504 66,940 19

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of mental health0.01355Moderately InformativeInherited
Disease Ontology (DO)schizophrenia0.0007274InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.00007487Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.1298Least InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.02304Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebrum0.03613Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral ventricles0.01992InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of the brainstem0.000001842Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal cortical gyration0.000008305Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of lateral ventricle0.000867Highly InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0009324Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.001184Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.003044Least InformativeInherited
Worm Phenotype (WP)cell development variant0.01269Least InformativeInherited
Worm Phenotype (WP)protein protein interaction variant0.0000000005418Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.00005511Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.0005361Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.009736Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.02162Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.07218Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.07535Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.5641Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.817Moderately InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.8215Moderately InformativeInherited
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.00000004537InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.0000001192InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.000008343InformativeDirect
Worm Phenotype (WP)cytokinesis variant emb0.0001779InformativeDirect
Worm Phenotype (WP)mitosis variant0.0005244InformativeDirect
Worm Phenotype (WP)avoids bacterial lawn0.0009376InformativeDirect
Worm Phenotype (WP)cell migration variant0.001257InformativeInherited
Worm Phenotype (WP)cell component localization variant0.003836InformativeInherited
Worm Phenotype (WP)gonad development variant0.01134InformativeInherited
Worm Phenotype (WP)epithelial system development variant0.04352InformativeInherited
Worm Phenotype (WP)RNA expression variant0.2456InformativeInherited
Worm Phenotype (WP)egg laying variant0.5999InformativeInherited
Worm Phenotype (WP)locomotion reduced0.6413InformativeInherited
Worm Phenotype (WP)pronucleus centrosomes defective early emb0.00000000005494Highly InformativeDirect
Worm Phenotype (WP)RAB-11 recycling endosome localization variant0.000001567Highly InformativeDirect
Worm Phenotype (WP)sluggish0.00003854Highly InformativeDirect
Worm Phenotype (WP)miRNA expression variant0.00004024Highly InformativeDirect
Worm Phenotype (WP)male mating variant0.0001239Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0001725Highly InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.0001826Highly InformativeDirect
Worm Phenotype (WP)cuticle morphology variant0.0003119Highly InformativeDirect
Worm Phenotype (WP)male somatic gonad development variant0.0003319Highly InformativeDirect
Worm Phenotype (WP)gonad arm morphology variant0.0005828Highly InformativeDirect
Worm Phenotype (WP)axon morphology variant0.0009445Highly InformativeDirect
Worm Phenotype (WP)synapse morphology variant0.006063Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)fertile0.0545Moderately InformativeInherited
Fly Phenotype (FP)cell cycle defective0.0002406InformativeDirect
Fly Phenotype (FP)wild-type0.0002408InformativeDirect
Fly Phenotype (FP)male fertile0.000003822Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)multi-tissue structure0.03524Least InformativeInherited
Fly Anatomy (FA)somatic cell0.9503Least InformativeInherited
Fly Anatomy (FA)gonad0.002506Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.05641Moderately InformativeInherited
Fly Anatomy (FA)germline cell0.002507InformativeInherited
Fly Anatomy (FA)male-specific anatomical entity0.006006InformativeInherited
Fly Anatomy (FA)fat body0.02828InformativeInherited
Fly Anatomy (FA)somatic stem cell0.2594InformativeInherited
Fly Anatomy (FA)fat cell0.000005348Highly InformativeDirect
Fly Anatomy (FA)spermatid0.00002876Highly InformativeDirect
Fly Anatomy (FA)type I neuroblast0.00007362Highly InformativeDirect
Fly Anatomy (FA)type II neuroblast0.0003053Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)sensory system0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.005035Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.0702Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.1139Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.1445Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.7578Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.00002749Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.003916Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.03501Moderately InformativeInherited
Xenopus ANatomical entity (XAN)epithelium0.000001432InformativeDirect
Xenopus ANatomical entity (XAN)dermal system0.00008823InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.000693InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.106InformativeInherited
Xenopus ANatomical entity (XAN)spinal cord0.1836InformativeInherited
Xenopus ANatomical entity (XAN)cell part0.00000000000000779Highly InformativeDirect
Xenopus ANatomical entity (XAN)ciliated cell0.00000000000004725Highly InformativeDirect
Xenopus ANatomical entity (XAN)epithelial cell0.00000000009142Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.000000003676Highly InformativeDirect
Xenopus ANatomical entity (XAN)epidermis0.000004933Highly InformativeDirect
Xenopus ANatomical entity (XAN)vegetal hemisphere0.0001605Highly InformativeDirect
Xenopus ANatomical entity (XAN)archenteron0.001301Highly InformativeInherited
Xenopus ANatomical entity (XAN)intersomitic region0.008999Highly InformativeInherited
Xenopus ANatomical entity (XAN)cranial nerve1Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)vascular system0.006386InformativeInherited

Document: AP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Tubulin nucleotide-binding domain-like domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]