SUPERFAMILY 1.75 HMM library and genome assignments server

SUPERFAMILY 2 can be accessed from Please contact us if you experience any problems.

cAMP-binding domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Double-stranded beta-helix [ 51181] (7)
Superfamily:   cAMP-binding domain-like [ 51206] (3)
Family:   cAMP-binding domain [ 51210] (12)

Family statistics
Genomes (852) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 3,596 11,435 30
Proteins 2,960 9,739 26

Enzyme Commission (EC)

show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.000000000001257Moderately InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the eye0.1437Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.5618Least InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.03034Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.2519Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal electroretinogram0.00003823Highly InformativeDirect
Phenotypic Abnormality (PA)Photophobia0.0006441Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.03745Least InformativeInherited
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.05957Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.3505Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.355Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.4278Moderately InformativeInherited
Mammalian Phenotype (MP)decreased neuron number0.0407InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.5304InformativeInherited
Mammalian Phenotype (MP)decreased retinal photoreceptor cell number0.0009046Highly InformativeDirect
Mammalian Phenotype (MP)abnormal olfactory bulb morphology0.001568Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.01091Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.0129Least InformativeInherited
Worm Phenotype (WP)cell development variant0.03928Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.09804Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.00007263Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.001854Moderately InformativeInherited
Worm Phenotype (WP)body region morphology variant0.001891Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.203Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.4237Moderately InformativeInherited
Worm Phenotype (WP)nervous system physiology variant0.0002589InformativeDirect
Worm Phenotype (WP)organism temperature response variant0.0006266InformativeDirect
Worm Phenotype (WP)head movement variant0.0006372InformativeDirect
Worm Phenotype (WP)chemosensory response variant0.002456InformativeInherited
Worm Phenotype (WP)cell fate specification variant0.003539InformativeInherited
Worm Phenotype (WP)body posture variant0.007936InformativeInherited
Worm Phenotype (WP)foraging behavior variant0.02966InformativeInherited
Worm Phenotype (WP)locomotor coordination variant0.07499InformativeInherited
Worm Phenotype (WP)egg laying variant0.1142InformativeInherited
Worm Phenotype (WP)velocity of movement variant0.1316InformativeInherited
Worm Phenotype (WP)odorant positive chemotaxis variant0.00000002146Highly InformativeDirect
Worm Phenotype (WP)positive chemotaxis defective0.00000003331Highly InformativeDirect
Worm Phenotype (WP)loss of left right asymmetry0.0000004517Highly InformativeDirect
Worm Phenotype (WP)carbon dioxide avoidance variant0.0000006596Highly InformativeDirect
Worm Phenotype (WP)neuronal cell fate specification variant0.000002689Highly InformativeDirect
Worm Phenotype (WP)thermotaxis variant0.00001391Highly InformativeDirect
Worm Phenotype (WP)neuron physiology variant0.00001479Highly InformativeDirect
Worm Phenotype (WP)coiling frequency variant0.0001942Highly InformativeDirect
Worm Phenotype (WP)dumpy0.0002007Highly InformativeDirect
Worm Phenotype (WP)body posture wavelength variant0.0002752Highly InformativeDirect
Worm Phenotype (WP)path curvature variant0.0002897Highly InformativeDirect
Worm Phenotype (WP)forward point velocity variant0.0003044Highly InformativeDirect
Worm Phenotype (WP)body posture amplitude variant0.000336Highly InformativeDirect
Worm Phenotype (WP)backward point velocity variant0.000344Highly InformativeDirect
Worm Phenotype (WP)egg laying defective0.0004701Highly InformativeDirect
Worm Phenotype (WP)amplitude of sinusoidal movement variant0.0006632Highly InformativeDirect
Worm Phenotype (WP)male mating variant0.0007316Highly InformativeDirect
Worm Phenotype (WP)frequency of body bend variant0.0007599Highly InformativeDirect
Worm Phenotype (WP)growth rate variant0.0008831Highly InformativeDirect
Worm Phenotype (WP)aqueous positive chemotaxis variant0.07656Highly InformativeInherited
Worm Phenotype (WP)negative chemotaxis variant0.1607Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)sensory perception defective0.0003321Highly InformativeDirect
Fly Phenotype (FP)chemical resistant0.00091Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0Least InformativeDirect
Fly Anatomy (FA)segment0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferases0.9807Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.000000000001583InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 43 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a cAMP-binding domain-like domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]