cAMP-binding domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: Double-stranded beta-helix [ 51181] (7)
• Superfamily: cAMP-binding domain-like [ 51206] (3)
• Family: cAMP-binding domain [ 51210] (12)

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Family statistics

	Genomes (852)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	3,596	11,435	30
Proteins	2,960	9,739	26

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Lysophospholipase	0	2.264	--	DIRECT
Enzyme Commission (EC)	cGMP-dependent protein kinase	0	2.741	--	DIRECT
Enzyme Commission (EC)	Hydrolases	3.476e-16	0.01852	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorous-containing groups	0.02255	0.2728	--	INHERITED FROM: cGMP-dependent protein kinase || Protein-serine/threonine kinases
Enzyme Commission (EC)	Transferases	0.9653	0	--	INHERITED FROM: cGMP-dependent protein kinase || Protein-serine/threonine kinases
Enzyme Commission (EC)	Acting on ester bonds	0	0.5107	Least Informative	DIRECT
Enzyme Commission (EC)	Carboxylic ester hydrolases	0	1.21	Moderately Informative	DIRECT
Enzyme Commission (EC)	Protein-serine/threonine kinases	0.000000000001257	1.042	Moderately Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormal visual electrophysiology	0.0002597	2.161	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0.08823	0.2371	--	INHERITED FROM: Photophobia
Phenotypic Abnormality (PA)	Abnormality of vision	0.1115	1.258	--	INHERITED FROM: Photophobia
Phenotypic Abnormality (PA)	Abnormality of the eye	0.1437	0.5703	Least Informative	INHERITED FROM: Abnormal electroretinogram || Abnormal visual electrophysiology || Photophobia
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0.5618	0.3869	Least Informative	INHERITED FROM: Photophobia
Phenotypic Abnormality (PA)	Behavioral abnormality	0.03034	1.082	Moderately Informative	INHERITED FROM: Photophobia
Phenotypic Abnormality (PA)	Abnormal eye physiology	0.2519	0.7903	Moderately Informative	INHERITED FROM: Abnormal electroretinogram || Abnormal visual electrophysiology || Photophobia
Phenotypic Abnormality (PA)	Abnormal electroretinogram	0.00003823	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Photophobia	0.0006441	1.985	Highly Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal olfactory bulb glomerular layer morphology	0.000008287	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal olfactory lobe morphology	0.005313	1.758	--	INHERITED FROM: abnormal olfactory bulb glomerular layer morphology
Mammalian Phenotype (MP)	abnormal retinal photoreceptor layer morphology	0.01132	1.758	--	INHERITED FROM: decreased retinal photoreceptor cell number
Mammalian Phenotype (MP)	abnormal olfactory bulb layer morphology	0.0115	2.302	--	INHERITED FROM: abnormal olfactory bulb glomerular layer morphology
Mammalian Phenotype (MP)	abnormal sensory neuron morphology	0.01839	1.156	--	INHERITED FROM: decreased retinal photoreceptor cell number
Mammalian Phenotype (MP)	abnormal retinal layer morphology	0.03243	1.399	--	INHERITED FROM: decreased retinal photoreceptor cell number
Mammalian Phenotype (MP)	abnormal neuron number	0.07477	1.399	--	INHERITED FROM: decreased retinal photoreceptor cell number
Mammalian Phenotype (MP)	abnormal telencephalon morphology	0.09756	1.261	--	INHERITED FROM: abnormal olfactory bulb glomerular layer morphology
Mammalian Phenotype (MP)	abnormal retinal photoreceptor morphology	0.1127	1.758	--	INHERITED FROM: decreased retinal photoreceptor cell number
Mammalian Phenotype (MP)	abnormal retina morphology	0.1192	1.241	--	INHERITED FROM: decreased retinal photoreceptor cell number
Mammalian Phenotype (MP)	abnormal ocular fundus morphology	0.1222	1.241	--	INHERITED FROM: decreased retinal photoreceptor cell number
Mammalian Phenotype (MP)	decreased sensory neuron number	0.1329	1.7	--	INHERITED FROM: decreased retinal photoreceptor cell number
Mammalian Phenotype (MP)	abnormal somatic nervous system morphology	0.1449	0.931	--	INHERITED FROM: decreased retinal photoreceptor cell number
Mammalian Phenotype (MP)	abnormal posterior eye segment morphology	0.1507	1.223	--	INHERITED FROM: decreased retinal photoreceptor cell number
Mammalian Phenotype (MP)	abnormal forebrain morphology	0.1839	1.188	--	INHERITED FROM: abnormal olfactory bulb glomerular layer morphology
Mammalian Phenotype (MP)	vision/eye phenotype	0.4176	0.8789	--	INHERITED FROM: decreased retinal photoreceptor cell number
Mammalian Phenotype (MP)	abnormal nervous system morphology	0.9908	0.5861	--	INHERITED FROM: abnormal olfactory bulb glomerular layer morphology || decreased retinal photoreceptor cell number
Mammalian Phenotype (MP)	nervous system phenotype	0.03745	0.4959	Least Informative	INHERITED FROM: abnormal olfactory bulb glomerular layer morphology || decreased retinal photoreceptor cell number
Mammalian Phenotype (MP)	abnormal somatic sensory system morphology	0.05957	1.023	Moderately Informative	INHERITED FROM: decreased retinal photoreceptor cell number
Mammalian Phenotype (MP)	abnormal neuron morphology	0.3505	0.8323	Moderately Informative	INHERITED FROM: decreased retinal photoreceptor cell number
Mammalian Phenotype (MP)	abnormal eye morphology	0.355	0.9129	Moderately Informative	INHERITED FROM: decreased retinal photoreceptor cell number
Mammalian Phenotype (MP)	abnormal brain morphology	0.4278	0.9799	Moderately Informative	INHERITED FROM: abnormal olfactory bulb glomerular layer morphology
Mammalian Phenotype (MP)	decreased neuron number	0.0407	1.562	Informative	INHERITED FROM: decreased retinal photoreceptor cell number
Mammalian Phenotype (MP)	abnormal retinal neuronal layer morphology	0.5304	1.427	Informative	INHERITED FROM: decreased retinal photoreceptor cell number
Mammalian Phenotype (MP)	decreased retinal photoreceptor cell number	0.0009046	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal olfactory bulb morphology	0.001568	1.904	Highly Informative	INHERITED FROM: abnormal olfactory bulb glomerular layer morphology

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	larval development variant	0	0.4322	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	neuron function reduced	0.000000001127	2.769	--	DIRECT
Worm Phenotype (WP)	odorant positive chemotaxis defective	0.000000001449	2.292	--	DIRECT
Worm Phenotype (WP)	sodium chloride chemotaxis defective	0.0000000151	2.468	--	DIRECT
Worm Phenotype (WP)	benzaldehyde chemotaxis defective	0.00000001763	2.769	--	DIRECT
Worm Phenotype (WP)	butanone chemotaxis variant	0.00000006988	2.769	--	DIRECT
Worm Phenotype (WP)	odorant chemosensory response variant	0.0000001049	1.814	--	DIRECT
Worm Phenotype (WP)	sodium chloride chemotaxis variant	0.0000001262	2.167	--	DIRECT
Worm Phenotype (WP)	odorant negative chemotaxis defective	0.0000001607	2.292	--	DIRECT
Worm Phenotype (WP)	loss of asymmetry ASE	0.0000002061	2.292	--	DIRECT
Worm Phenotype (WP)	positive chemotaxis variant	0.0000003627	1.689	--	DIRECT
Worm Phenotype (WP)	carbon dioxide response variant	0.0000007434	1.924	--	DIRECT
Worm Phenotype (WP)	benzaldehyde chemotaxis variant	0.000001479	2.292	--	DIRECT
Worm Phenotype (WP)	chemotaxis variant	0.000002856	1.513	--	DIRECT
Worm Phenotype (WP)	bloated	0.000005973	2.769	--	DIRECT
Worm Phenotype (WP)	chemosensory behavior variant	0.00008141	1.49	--	DIRECT
Worm Phenotype (WP)	thermosensory behavior variant	0.0001269	1.866	--	DIRECT
Worm Phenotype (WP)	roller	0.0001358	2.292	--	DIRECT
Worm Phenotype (WP)	male mating defective	0.000178	2.167	--	DIRECT
Worm Phenotype (WP)	coiling variant	0.0002823	1.769	--	DIRECT
Worm Phenotype (WP)	turning frequency variant	0.000361	1.623	--	DIRECT
Worm Phenotype (WP)	turning variant	0.0003963	1.623	--	DIRECT
Worm Phenotype (WP)	nose movement variant	0.0005636	1.727	--	DIRECT
Worm Phenotype (WP)	head bend angle variant	0.0005754	1.655	--	DIRECT
Worm Phenotype (WP)	muscle system physiology variant	0.0008287	1.306	--	DIRECT
Worm Phenotype (WP)	large	0.0008974	2.468	--	DIRECT
Worm Phenotype (WP)	directionality variant	0.0009655	1.565	--	DIRECT
Worm Phenotype (WP)	anesthetic response variant	0.001253	1.769	--	INHERITED FROM: carbon dioxide avoidance variant || carbon dioxide response variant
Worm Phenotype (WP)	body bend variant	0.001489	1.623	--	INHERITED FROM: amplitude of sinusoidal movement variant || frequency of body bend variant
Worm Phenotype (WP)	sinusoidal movement variant	0.00156	1.623	--	INHERITED FROM: frequency of body bend variant || amplitude of sinusoidal movement variant
Worm Phenotype (WP)	activity level variant	0.00304	1.337	--	INHERITED FROM: forward point velocity variant || backward point velocity variant
Worm Phenotype (WP)	egg retention	0.005549	2.769	--	INHERITED FROM: bloated
Worm Phenotype (WP)	copulation variant	0.006417	1.866	--	INHERITED FROM: male mating defective || male mating variant
Worm Phenotype (WP)	sexually dimorphic behavior variant	0.006417	1.866	--	INHERITED FROM: male mating defective || male mating variant
Worm Phenotype (WP)	body length variant	0.007939	1.292	--	INHERITED FROM: dumpy
Worm Phenotype (WP)	localized movement variant	0.008315	1.623	--	INHERITED FROM: head movement variant || nose movement variant || head bend angle variant
Worm Phenotype (WP)	locomotion variant	0.01052	1.053	--	INHERITED FROM: amplitude of sinusoidal movement variant || directionality variant || turning frequency variant || turning variant || backward point velocity variant || path curvature variant || forward point velocity variant || frequency of body bend variant || roller
Worm Phenotype (WP)	behavior variant	0.01124	0.6859	--	INHERITED FROM: thermosensory behavior variant || odorant chemosensory response variant || frequency of body bend variant || egg laying defective || body posture wavelength variant || backward point velocity variant || odorant negative chemotaxis defective || male mating variant || chemosensory behavior variant || head bend angle variant || male mating defective || benzaldehyde chemotaxis defective || odorant positive chemotaxis variant || coiling variant || positive chemotaxis variant || positive chemotaxis defective || turning frequency variant || butanone chemotaxis variant || forward point velocity variant || sodium chloride chemotaxis defective || chemotaxis variant || thermotaxis variant || odorant positive chemotaxis defective || coiling frequency variant || directionality variant || roller || nose movement variant || bloated || body posture amplitude variant || path curvature variant || sodium chloride chemotaxis variant || turning variant || benzaldehyde chemotaxis variant || head movement variant || amplitude of sinusoidal movement variant
Worm Phenotype (WP)	body width variant	0.01167	1.237	--	INHERITED FROM: dumpy
Worm Phenotype (WP)	odorant negative chemotaxis variant	0.02498	2.292	--	INHERITED FROM: odorant negative chemotaxis defective
Worm Phenotype (WP)	aqueous chemosensory response variant	0.05035	1.814	--	INHERITED FROM: sodium chloride chemotaxis variant || sodium chloride chemotaxis defective
Worm Phenotype (WP)	AWC odorant chemotaxis defective	0.07533	2.468	--	INHERITED FROM: benzaldehyde chemotaxis defective
Worm Phenotype (WP)	aqueous positive chemotaxis defective	0.08678	2.07	--	INHERITED FROM: sodium chloride chemotaxis defective
Worm Phenotype (WP)	drug response variant	0.1624	1.135	--	INHERITED FROM: carbon dioxide response variant || carbon dioxide avoidance variant
Worm Phenotype (WP)	AWC odorant chemotaxis variant	0.5822	2.167	--	INHERITED FROM: butanone chemotaxis variant || benzaldehyde chemotaxis defective || benzaldehyde chemotaxis variant
Worm Phenotype (WP)	growth variant	0.6146	0.3438	--	INHERITED FROM: growth rate variant
Worm Phenotype (WP)	body morphology variant	0.6612	1.145	--	INHERITED FROM: dumpy || large
Worm Phenotype (WP)	body size variant	0.8097	1.189	--	INHERITED FROM: large || dumpy
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: frequency of body bend variant || hermaphrodite fertility variant || male mating defective || butanone chemotaxis variant || roller || carbon dioxide avoidance variant || reproductive system physiology variant || male mating variant || loss of left right asymmetry || turning frequency variant || chemical response variant || nose movement variant || growth rate variant || sodium chloride chemotaxis variant || organism homeostasis metabolism variant || benzaldehyde chemotaxis variant || head bend angle variant || lethal || larval development variant || amplitude of sinusoidal movement variant || organism physiology variant || chemosensory behavior variant || neuron function reduced || positive chemotaxis variant || positive chemotaxis defective || carbon dioxide response variant || thermotaxis variant || coiling frequency variant || turning variant || backward point velocity variant || odorant negative chemotaxis defective || development variant || odorant positive chemotaxis variant || sodium chloride chemotaxis defective || odorant positive chemotaxis defective || organism temperature response variant || hermaphrodite sterile || egg laying defective || body posture wavelength variant || hermaphrodite fertility reduced || nervous system physiology variant || chemotaxis variant || embryonic development variant || embryonic lethal || neuron physiology variant || bloated || path curvature variant || head movement variant || fertility variant || odorant chemosensory response variant || loss of asymmetry ASE || muscle system physiology variant || benzaldehyde chemotaxis defective || coiling variant || neuronal cell fate specification variant || body posture amplitude variant || postembryonic development variant || thermosensory behavior variant || organ system physiology variant || maternal sterile || organism development variant || forward point velocity variant || directionality variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	male behavior variant	1	1.866	--	INHERITED FROM: male mating variant || male mating defective
Worm Phenotype (WP)	organism behavior variant	0.01091	0.6859	Least Informative	INHERITED FROM: head bend angle variant || male mating defective || coiling variant || odorant positive chemotaxis variant || benzaldehyde chemotaxis defective || positive chemotaxis variant || positive chemotaxis defective || turning frequency variant || thermosensory behavior variant || odorant chemosensory response variant || egg laying defective || frequency of body bend variant || body posture wavelength variant || odorant negative chemotaxis defective || backward point velocity variant || male mating variant || chemosensory behavior variant || roller || nose movement variant || bloated || path curvature variant || body posture amplitude variant || sodium chloride chemotaxis variant || turning variant || benzaldehyde chemotaxis variant || amplitude of sinusoidal movement variant || head movement variant || butanone chemotaxis variant || sodium chloride chemotaxis defective || forward point velocity variant || chemotaxis variant || thermotaxis variant || odorant positive chemotaxis defective || coiling frequency variant || directionality variant
Worm Phenotype (WP)	organism environmental stimulus response variant	0.0129	0.6614	Least Informative	INHERITED FROM: thermosensory behavior variant || odorant chemosensory response variant || odorant negative chemotaxis defective || odorant positive chemotaxis variant || benzaldehyde chemotaxis defective || positive chemotaxis defective || positive chemotaxis variant || carbon dioxide response variant || butanone chemotaxis variant || sodium chloride chemotaxis defective || chemotaxis variant || odorant positive chemotaxis defective || thermotaxis variant || chemical response variant || organism temperature response variant || carbon dioxide avoidance variant || benzaldehyde chemotaxis variant || sodium chloride chemotaxis variant
Worm Phenotype (WP)	cell development variant	0.03928	0.6752	Least Informative	INHERITED FROM: neuronal cell fate specification variant || loss of asymmetry ASE || loss of left right asymmetry
Worm Phenotype (WP)	cell physiology variant	0.09804	0.5955	Least Informative	INHERITED FROM: neuron function reduced || neuron physiology variant
Worm Phenotype (WP)	chemical response variant	0.00007263	0.9053	Moderately Informative	DIRECT
Worm Phenotype (WP)	organism segment morphology variant	0.001854	1.087	Moderately Informative	INHERITED FROM: large || dumpy
Worm Phenotype (WP)	body region morphology variant	0.001891	1.087	Moderately Informative	INHERITED FROM: large || dumpy
Worm Phenotype (WP)	movement variant	0.203	1.02	Moderately Informative	INHERITED FROM: forward point velocity variant || nose movement variant || frequency of body bend variant || backward point velocity variant || path curvature variant || roller || head bend angle variant || turning frequency variant || head movement variant || directionality variant || amplitude of sinusoidal movement variant || turning variant
Worm Phenotype (WP)	organism stress response variant	0.4237	0.9693	Moderately Informative	INHERITED FROM: thermosensory behavior variant || thermotaxis variant || organism temperature response variant
Worm Phenotype (WP)	nervous system physiology variant	0.0002589	1.727	Informative	DIRECT
Worm Phenotype (WP)	organism temperature response variant	0.0006266	1.593	Informative	DIRECT
Worm Phenotype (WP)	head movement variant	0.0006372	1.623	Informative	DIRECT
Worm Phenotype (WP)	chemosensory response variant	0.002456	1.49	Informative	INHERITED FROM: odorant chemosensory response variant || butanone chemotaxis variant || odorant positive chemotaxis variant || benzaldehyde chemotaxis defective || odorant negative chemotaxis defective || chemotaxis variant || sodium chloride chemotaxis defective || benzaldehyde chemotaxis variant || positive chemotaxis defective || odorant positive chemotaxis defective || sodium chloride chemotaxis variant || positive chemotaxis variant
Worm Phenotype (WP)	cell fate specification variant	0.003539	1.513	Informative	INHERITED FROM: loss of left right asymmetry || neuronal cell fate specification variant || loss of asymmetry ASE
Worm Phenotype (WP)	body posture variant	0.007936	1.513	Informative	INHERITED FROM: coiling frequency variant || body posture wavelength variant || coiling variant || body posture amplitude variant
Worm Phenotype (WP)	foraging behavior variant	0.02966	1.593	Informative	INHERITED FROM: nose movement variant
Worm Phenotype (WP)	locomotor coordination variant	0.07499	1.446	Informative	INHERITED FROM: roller || turning variant || path curvature variant || directionality variant || amplitude of sinusoidal movement variant || frequency of body bend variant || turning frequency variant
Worm Phenotype (WP)	egg laying variant	0.1142	1.513	Informative	INHERITED FROM: bloated || egg laying defective
Worm Phenotype (WP)	velocity of movement variant	0.1316	1.655	Informative	INHERITED FROM: forward point velocity variant || backward point velocity variant
Worm Phenotype (WP)	odorant positive chemotaxis variant	0.00000002146	1.924	Highly Informative	DIRECT
Worm Phenotype (WP)	positive chemotaxis defective	0.00000003331	1.99	Highly Informative	DIRECT
Worm Phenotype (WP)	loss of left right asymmetry	0.0000004517	1.99	Highly Informative	DIRECT
Worm Phenotype (WP)	carbon dioxide avoidance variant	0.0000006596	1.99	Highly Informative	DIRECT
Worm Phenotype (WP)	neuronal cell fate specification variant	0.000002689	1.99	Highly Informative	DIRECT
Worm Phenotype (WP)	thermotaxis variant	0.00001391	1.866	Highly Informative	DIRECT
Worm Phenotype (WP)	neuron physiology variant	0.00001479	2.167	Highly Informative	DIRECT
Worm Phenotype (WP)	coiling frequency variant	0.0001942	1.814	Highly Informative	DIRECT
Worm Phenotype (WP)	dumpy	0.0002007	1.814	Highly Informative	DIRECT
Worm Phenotype (WP)	body posture wavelength variant	0.0002752	2.167	Highly Informative	DIRECT
Worm Phenotype (WP)	path curvature variant	0.0002897	1.99	Highly Informative	DIRECT
Worm Phenotype (WP)	forward point velocity variant	0.0003044	1.99	Highly Informative	DIRECT
Worm Phenotype (WP)	body posture amplitude variant	0.000336	2.167	Highly Informative	DIRECT
Worm Phenotype (WP)	backward point velocity variant	0.000344	1.866	Highly Informative	DIRECT
Worm Phenotype (WP)	egg laying defective	0.0004701	1.99	Highly Informative	DIRECT
Worm Phenotype (WP)	amplitude of sinusoidal movement variant	0.0006632	1.866	Highly Informative	DIRECT
Worm Phenotype (WP)	male mating variant	0.0007316	1.866	Highly Informative	DIRECT
Worm Phenotype (WP)	frequency of body bend variant	0.0007599	2.07	Highly Informative	DIRECT
Worm Phenotype (WP)	growth rate variant	0.0008831	1.924	Highly Informative	DIRECT
Worm Phenotype (WP)	aqueous positive chemotaxis variant	0.07656	1.866	Highly Informative	INHERITED FROM: sodium chloride chemotaxis variant || sodium chloride chemotaxis defective
Worm Phenotype (WP)	negative chemotaxis variant	0.1607	1.99	Highly Informative	INHERITED FROM: odorant negative chemotaxis defective

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	hyperactive	0.00001468	2.386	--	DIRECT
Fly Phenotype (FP)	phenotype	0.6999	0.06546	--	INHERITED FROM: chemical resistant || hyperactive || sensory perception defective
Fly Phenotype (FP)	sensory perception defective	0.0003321	1.784	Highly Informative	DIRECT
Fly Phenotype (FP)	chemical resistant	0.00091	1.784	Highly Informative	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.1823	--	DIRECT
Fly Anatomy (FA)	cell	0	0.4069	--	DIRECT
Fly Anatomy (FA)	organism subdivision	0	0.5027	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || segment || cell || multi-tissue structure || tagma || organ system subdivision || organ system || organism subdivision || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: organ system || organism subdivision || multicellular structure || tagma || organ system subdivision || cell || multi-tissue structure || segment || organism
Fly Anatomy (FA)	anterior-posterior subdivision of organism	1	0.5027	--	INHERITED FROM: tagma || segment
Fly Anatomy (FA)	tagma	0	0.5027	Least Informative	DIRECT
Fly Anatomy (FA)	segment	0	0.6568	Least Informative	DIRECT
Fly Anatomy (FA)	multi-tissue structure	0	0.6038	Least Informative	DIRECT
Fly Anatomy (FA)	organ system subdivision	0	0.4301	Least Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: whole organism

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: multicellular anatomical structure || anatomical region || organism subdivision
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	plant cell	0	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || shoot system || plant cell
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: shoot system
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || plant organ development stage

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	cGMP-dependent protein kinase	0	3.23	--	DIRECT
Enzyme Commission (EC)	Lysophospholipase	0	2.452	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0.01643	0.7021	--	INHERITED FROM: Protein-serine/threonine kinases || cGMP-dependent protein kinase
Enzyme Commission (EC)	Hydrolases	0	0.4043	Least Informative	DIRECT
Enzyme Commission (EC)	Transferases	0.9807	0.3972	Least Informative	INHERITED FROM: cGMP-dependent protein kinase || Protein-serine/threonine kinases
Enzyme Commission (EC)	Acting on ester bonds	0	0.8756	Moderately Informative	DIRECT
Enzyme Commission (EC)	Carboxylic ester hydrolases	0	1.539	Informative	DIRECT
Enzyme Commission (EC)	Protein-serine/threonine kinases	0.000000000001583	1.437	Informative	DIRECT

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