SUPERFAMILY 1.75 HMM library and genome assignments server

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WD40-repeat family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   7-bladed beta-propeller [ 50964] (14)
Superfamily:   WD40 repeat-like [ 50978] (2)
Family:   WD40-repeat [ 50979] (10)

Family statistics
Genomes (647) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 14,751 47,209 17
Proteins 13,922 43,768 15

Enzyme Commission (EC)

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EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0.000172Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.00000009517Moderately InformativeDirect
Enzyme Commission (EC)Cis-trans Isomerases1InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.3017Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.2529Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal morphology0.6731InformativeInherited

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.000003545Least InformativeDirect
Worm Phenotype (WP)cell development variant0.00007577Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.00315Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.02841Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.2371Least InformativeInherited
Worm Phenotype (WP)germ cell development variant0.000008337Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.0004944Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.004242Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.004921Moderately InformativeInherited
Worm Phenotype (WP)protein protein interaction variant0.03216Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.1465Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.2927Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.4442Moderately InformativeInherited
Worm Phenotype (WP)vulva morphology variant0.000007186InformativeDirect
Worm Phenotype (WP)brood size variant0.00004016InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.0004952InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.01153InformativeInherited
Worm Phenotype (WP)chemical resistant0.03667InformativeInherited
Worm Phenotype (WP)cell fate specification variant0.09561InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.1471InformativeInherited
Worm Phenotype (WP)drug resistant0.2255InformativeInherited
Worm Phenotype (WP)chemosensory response variant0.4064InformativeInherited
Worm Phenotype (WP)vulva development variant0.4621InformativeInherited
Worm Phenotype (WP)cell number increased0.9827InformativeInherited
Worm Phenotype (WP)dauer larva physiology variant1InformativeInherited
Worm Phenotype (WP)cell proliferation increased0.00001334Highly InformativeDirect
Worm Phenotype (WP)slow embryonic development0.0001559Highly InformativeDirect
Worm Phenotype (WP)multivulva0.0004569Highly InformativeDirect
Worm Phenotype (WP)negative chemotaxis variant0.005518Highly InformativeInherited
Worm Phenotype (WP)cytoplasmic appearance defective early emb0.0428Highly InformativeInherited
Worm Phenotype (WP)intestinal development variant0.07514Highly InformativeInherited
Worm Phenotype (WP)dauer formation variant0.145Highly InformativeInherited

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0.01705Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.1236Least InformativeInherited
Zebrafish Anatomy (ZA)organism subdivision0.2422Least InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.2443Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.2537Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.4099Least InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.002094Moderately InformativeInherited
Zebrafish Anatomy (ZA)head0.02598Moderately InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.2359Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.6076Moderately InformativeInherited
Zebrafish Anatomy (ZA)eye0.003945InformativeInherited
Zebrafish Anatomy (ZA)neuron0.3213InformativeInherited
Zebrafish Anatomy (ZA)receptor cell (sensu Animalia)0.002532Highly InformativeInherited
Zebrafish Anatomy (ZA)retinal outer nuclear layer0.004385Highly InformativeInherited
Zebrafish Anatomy (ZA)retinal photoreceptor layer0.006825Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)urogenital system0.00000004525Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0.001007Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.02799Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.2957Least InformativeInherited
Xenopus ANatomical entity (XAN)testis0.00000000000915Moderately InformativeDirect
Xenopus ANatomical entity (XAN)germ cell0.00001271Moderately InformativeDirect
Xenopus ANatomical entity (XAN)alimentary system0.01363Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.2757Moderately InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)plant sperm cell0.00005118InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0.0000002036Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.9376Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0.000000000001047Moderately InformativeDirect
Enzyme Commission (EC)Isomerases0.02409Moderately InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.03651Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0000001361InformativeDirect
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0.000002938Highly InformativeDirect
Enzyme Commission (EC)Cis-trans isomerases1Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 35 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a WD40 repeat-like domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]