Histone lysine methyltransferases family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (174)
• Fold: beta-clip [ 51268] (7)
• Superfamily: SET domain [ 82199] (3)
• Family: Histone lysine methyltransferases [ 82200] (3)

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Family statistics

	Genomes (333)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	1,226	2,998	10
Proteins	1,225	2,996	10

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferases	0	0	--	DIRECT
Enzyme Commission (EC)	Transferring one-carbon groups	0	0.72	Least Informative	DIRECT
Enzyme Commission (EC)	Methyltransferases	0	0.8169	Moderately Informative	DIRECT
Enzyme Commission (EC)	Histone-lysine N-methyltransferase	0	1.595	Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Mode of Inheritance (MI)	Autosomal dominant inheritance	0	0.516	Least Informative	DIRECT
Mode of Inheritance (MI)	Sporadic	0.000591	2.021	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of head or neck	0	0.4454	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the head	0	0.4538	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0	0.2371	--	DIRECT
Phenotypic Abnormality (PA)	Global developmental delay	0	1.232	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal muscle tone	0	0.8942	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal muscle physiology	0	0.6915	--	DIRECT
Phenotypic Abnormality (PA)	Neurodevelopmental abnormality	0	0.7381	--	DIRECT
Phenotypic Abnormality (PA)	Hypospadias	0.000004382	2.161	--	DIRECT
Phenotypic Abnormality (PA)	Displacement of the urethral meatus	0.000005873	2.161	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal testis morphology	0.00002314	1.559	--	DIRECT
Phenotypic Abnormality (PA)	Abnormally low-pitched voice	0.00002875	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Hip dislocation	0.00003512	1.617	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the hip bone	0.00007302	1.508	--	DIRECT
Phenotypic Abnormality (PA)	Lower extremity joint dislocation	0.00008949	1.617	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal external genitalia	0.0001138	1.421	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the male genitalia	0.0001224	1.421	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal hair morphology	0.0001438	1.207	--	DIRECT
Phenotypic Abnormality (PA)	Functional abnormality of the middle ear	0.0002481	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of forebrain morphology	0.0002651	0.9572	--	DIRECT
Phenotypic Abnormality (PA)	Posteriorly rotated ears	0.0002869	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Congenital abnormal hair pattern	0.0003027	1.985	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the frontal hairline	0.0003074	2.161	--	DIRECT
Phenotypic Abnormality (PA)	Talipes	0.0003217	1.86	--	DIRECT
Phenotypic Abnormality (PA)	Intestinal malrotation	0.0003236	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the ocular adnexa	0.0006158	1.082	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the lower urinary tract	0.0008043	2.161	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the ureter	0.001275	1.763	--	INHERITED FROM: Abnormal ureter physiology
Phenotypic Abnormality (PA)	Early onset of sexual maturation	0.001489	2.161	--	INHERITED FROM: Precocious puberty
Phenotypic Abnormality (PA)	Abnormality of the genital system	0.00154	0.9309	--	INHERITED FROM: Displacement of the urethral meatus || Abnormal testis morphology || Cryptorchidism || Abnormal reproductive system morphology || Abnormality of male external genitalia || Hypospadias || Abnormality of the male genitalia || Abnormal external genitalia
Phenotypic Abnormality (PA)	Abnormality of lower limb joint	0.003335	1.348	--	INHERITED FROM: Hip dislocation
Phenotypic Abnormality (PA)	Abnormality of brain morphology	0.003456	0.6631	--	INHERITED FROM: Ventriculomegaly || Abnormality of forebrain morphology || Abnormality of the cerebrum
Phenotypic Abnormality (PA)	Abnormality of the synovia	0.004167	1.508	--	INHERITED FROM: Hip dislocation
Phenotypic Abnormality (PA)	Abnormality of pelvic girdle bone morphology	0.004367	1.462	--	INHERITED FROM: Abnormality of the hip bone || Hip dislocation
Phenotypic Abnormality (PA)	Abnormal axial skeleton morphology	0.004654	0.6771	--	INHERITED FROM: Abnormality of skull size
Phenotypic Abnormality (PA)	Positional foot deformity	0.004999	1.86	--	INHERITED FROM: Talipes
Phenotypic Abnormality (PA)	Increased body weight	0.005842	1.684	--	INHERITED FROM: Obesity
Phenotypic Abnormality (PA)	Growth abnormality	0.006024	0.7903	--	INHERITED FROM: Obesity
Phenotypic Abnormality (PA)	Morphological abnormality of the central nervous system	0.008053	0.533	--	INHERITED FROM: Ventriculomegaly || Abnormality of forebrain morphology || Abnormality of the cerebrum
Phenotypic Abnormality (PA)	Puberty and gonadal disorders	0.008382	1.207	--	INHERITED FROM: Precocious puberty
Phenotypic Abnormality (PA)	Abnormality of the scalp	0.009263	1.86	--	INHERITED FROM: Abnormality of the frontal hairline || Abnormality of the hairline
Phenotypic Abnormality (PA)	Abnormal oral morphology	0.009422	0.7381	--	INHERITED FROM: Downturned corners of mouth
Phenotypic Abnormality (PA)	Abnormality of cardiovascular system morphology	0.01301	0.8391	--	INHERITED FROM: Abnormal cardiac septum morphology
Phenotypic Abnormality (PA)	Abnormality of the middle ear	0.01685	1.763	--	INHERITED FROM: Functional abnormality of the middle ear
Phenotypic Abnormality (PA)	Abnormal male urethral meatus morphology	0.02131	2.161	--	INHERITED FROM: Displacement of the urethral meatus || Hypospadias
Phenotypic Abnormality (PA)	Abnormal eye morphology	0.02171	0.7812	--	INHERITED FROM: Hypertelorism
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0.02638	0.4712	--	INHERITED FROM: Abnormality of the hip bone || Abnormality of skull size || Hip dislocation || Lower extremity joint dislocation
Phenotypic Abnormality (PA)	Abnormal ear morphology	0.02944	1.047	--	INHERITED FROM: Abnormality of the pinna || Abnormality of the outer ear || Functional abnormality of the middle ear || Posteriorly rotated ears
Phenotypic Abnormality (PA)	Abnormality of globe location	0.03189	1.763	--	INHERITED FROM: Hypertelorism
Phenotypic Abnormality (PA)	Abnormality of mouth shape	0.03249	1.985	--	INHERITED FROM: Downturned corners of mouth
Phenotypic Abnormality (PA)	Abnormality of the orbital region	0.03932	1.082	--	INHERITED FROM: Abnormality of the palpebral fissures || Abnormality of the ocular adnexa || Abnormal ocular adnexa morphology
Phenotypic Abnormality (PA)	Abnormal hair pattern	0.04561	1.985	--	INHERITED FROM: Abnormality of the frontal hairline || Congenital abnormal hair pattern || Abnormality of the hairline
Phenotypic Abnormality (PA)	Abnormal skull morphology	0.04923	0.8826	--	INHERITED FROM: Abnormality of skull size
Phenotypic Abnormality (PA)	Abnormality of the scalp hair	0.09033	1.86	--	INHERITED FROM: Abnormality of the hairline || Abnormality of the frontal hairline
Phenotypic Abnormality (PA)	Abnormal appendicular skeleton morphology	0.09887	0.8289	--	INHERITED FROM: Abnormality of the hip bone || Hip dislocation
Phenotypic Abnormality (PA)	Abnormality of skin morphology	0.1214	0.7722	--	INHERITED FROM: Regional abnormality of skin
Phenotypic Abnormality (PA)	Morphological abnormality of the gastrointestinal tract	0.1418	1.184	--	INHERITED FROM: Intestinal malrotation
Phenotypic Abnormality (PA)	Abdominal symptom	0.3173	1.161	--	INHERITED FROM: Feeding difficulties
Phenotypic Abnormality (PA)	Abnormality of the mouth	0.3885	0.7065	--	INHERITED FROM: Downturned corners of mouth
Phenotypic Abnormality (PA)	Abnormality of the foot	0.4188	1.082	--	INHERITED FROM: Talipes
Phenotypic Abnormality (PA)	Abnormal eyelid morphology	0.4401	1.232	--	INHERITED FROM: Abnormality of the palpebral fissures
Phenotypic Abnormality (PA)	Abnormality of the urinary system	0.5068	0.8496	--	INHERITED FROM: Abnormal ureter physiology || Hypospadias || Displacement of the urethral meatus || Abnormality of the lower urinary tract
Phenotypic Abnormality (PA)	Abnormality of the skin	0.7161	0.722	--	INHERITED FROM: Regional abnormality of skin
Phenotypic Abnormality (PA)	Abnormality of the face	0	0.533	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the musculature	0	0.5433	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0	0.3869	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of skeletal morphology	0.01989	0.513	Least Informative	INHERITED FROM: Lower extremity joint dislocation || Hip dislocation || Abnormality of skull size || Abnormality of the hip bone
Phenotypic Abnormality (PA)	Abnormality of the genitourinary system	0.03804	0.6051	Least Informative	INHERITED FROM: Hypospadias || Abnormality of the male genitalia || Abnormal external genitalia || Abnormal ureter physiology || Displacement of the urethral meatus || Abnormal testis morphology || Abnormality of male external genitalia || Abnormality of the lower urinary tract || Cryptorchidism || Abnormal reproductive system morphology
Phenotypic Abnormality (PA)	Abnormality of the integument	0.04375	0.6235	Least Informative	INHERITED FROM: Abnormality of skin adnexa morphology || Regional abnormality of skin || Congenital abnormal hair pattern || Abnormality of the frontal hairline || Abnormality of the hairline || Abnormal hair morphology
Phenotypic Abnormality (PA)	Abnormality of limbs	0.04889	0.6429	Least Informative	INHERITED FROM: Talipes || Hip dislocation
Phenotypic Abnormality (PA)	Abnormality of the digestive system	0.06842	0.5759	Least Informative	INHERITED FROM: Intestinal malrotation || Feeding difficulties
Phenotypic Abnormality (PA)	Abnormality of the eye	0.0952	0.5703	Least Informative	INHERITED FROM: Hypertelorism
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0.14	0.4756	Least Informative	INHERITED FROM: Abnormality of forebrain morphology || Ventriculomegaly || Abnormality of the cerebrum
Phenotypic Abnormality (PA)	Abnormality of the cardiovascular system	0.1431	0.5179	Least Informative	INHERITED FROM: Abnormal cardiac septum morphology
Phenotypic Abnormality (PA)	Abnormality of higher mental function	0	0.8092	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Neurodevelopmental delay	0	0.9853	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of skull size	0.00003082	1.101	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the cerebrum	0.0002281	0.971	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of skin adnexa morphology	0.0004131	1.184	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal ocular adnexa morphology	0.0005425	1.082	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal reproductive system morphology	0.0007128	1.031	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the lower limb	0.009842	0.9309	Moderately Informative	INHERITED FROM: Hip dislocation || Talipes
Phenotypic Abnormality (PA)	Abnormality of digestive system physiology	0.009904	0.9572	Moderately Informative	INHERITED FROM: Feeding difficulties
Phenotypic Abnormality (PA)	Abnormality of the upper urinary tract	0.01961	1.12	Moderately Informative	INHERITED FROM: Abnormal ureter physiology
Phenotypic Abnormality (PA)	Abnormality of connective tissue	0.02948	1.031	Moderately Informative	INHERITED FROM: Hernia
Phenotypic Abnormality (PA)	Abnormality of the ear	0.05145	0.9572	Moderately Informative	INHERITED FROM: Abnormality of the outer ear || Functional abnormality of the middle ear || Posteriorly rotated ears || Abnormality of the pinna
Phenotypic Abnormality (PA)	Abnormal joint morphology	0.06225	1.101	Moderately Informative	INHERITED FROM: Lower extremity joint dislocation || Hip dislocation
Phenotypic Abnormality (PA)	Abnormality of the endocrine system	0.08583	0.9183	Moderately Informative	INHERITED FROM: Precocious puberty
Phenotypic Abnormality (PA)	Abnormal heart morphology	0.3169	0.9183	Moderately Informative	INHERITED FROM: Abnormal cardiac septum morphology
Phenotypic Abnormality (PA)	Abnormality of digestive system morphology	0.3509	1.184	Moderately Informative	INHERITED FROM: Intestinal malrotation
Phenotypic Abnormality (PA)	Abnormality of body weight	0.4827	1.12	Moderately Informative	INHERITED FROM: Obesity
Phenotypic Abnormality (PA)	Abnormality of the gastrointestinal tract	0.6489	1.031	Moderately Informative	INHERITED FROM: Intestinal malrotation
Phenotypic Abnormality (PA)	Abnormal oral cavity morphology	1	0.8289	Moderately Informative	INHERITED FROM: Downturned corners of mouth
Phenotypic Abnormality (PA)	Abnormality of the palpebral fissures	0.00007406	1.559	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of male external genitalia	0.0000859	1.462	Informative	DIRECT
Phenotypic Abnormality (PA)	Hernia	0.0001283	1.617	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal cardiac septum morphology	0.0002461	1.559	Informative	DIRECT
Phenotypic Abnormality (PA)	Regional abnormality of skin	0.0004594	1.508	Informative	DIRECT
Phenotypic Abnormality (PA)	Obesity	0.0008472	1.684	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the outer ear	0.0009888	1.617	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the cerebral ventricles	0.003211	1.684	Informative	INHERITED FROM: Ventriculomegaly
Phenotypic Abnormality (PA)	Abnormality of the voice	0.007328	1.508	Informative	INHERITED FROM: Abnormally low-pitched voice
Phenotypic Abnormality (PA)	Joint dislocation	0.01228	1.508	Informative	INHERITED FROM: Hip dislocation || Lower extremity joint dislocation
Phenotypic Abnormality (PA)	Abnormality of the hip joint	0.0338	1.508	Informative	INHERITED FROM: Hip dislocation
Phenotypic Abnormality (PA)	Abnormality of the forehead	0.1626	1.684	Informative	INHERITED FROM: Abnormality of the frontal hairline
Phenotypic Abnormality (PA)	Abnormal intestine morphology	0.2829	1.421	Informative	INHERITED FROM: Intestinal malrotation
Phenotypic Abnormality (PA)	Cryptorchidism	0.000002746	1.763	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal ureter physiology	0.000006035	1.985	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Ventriculomegaly	0.000008982	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Precocious puberty	0.00003435	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the pinna	0.0000415	1.985	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the hairline	0.0002094	1.985	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Feeding difficulties	0.0002739	1.985	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Hypertelorism	0.0006161	1.985	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Downturned corners of mouth	0.0006881	1.985	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the urethra	0.005204	2.161	Highly Informative	INHERITED FROM: Displacement of the urethral meatus || Hypospadias
Phenotypic Abnormality (PA)	Abnormality of the penis	0.08512	1.86	Highly Informative	INHERITED FROM: Hypospadias || Displacement of the urethral meatus
Phenotypic Abnormality (PA)	Abnormal location of ears	0.3936	2.161	Highly Informative	INHERITED FROM: Posteriorly rotated ears

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	embryo phenotype	0.000008241	0.8708	--	DIRECT
Mammalian Phenotype (MP)	preweaning lethality	0.00001669	0.7055	--	DIRECT
Mammalian Phenotype (MP)	increased B cell derived lymphoma incidence	0.00001883	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal epigenetic regulation of gene expression	0.00006834	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal survival	0.0001487	0.6441	--	DIRECT
Mammalian Phenotype (MP)	arrest of male meiosis	0.0008175	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal meiosis	0.004959	1.904	--	INHERITED FROM: arrest of male meiosis
Mammalian Phenotype (MP)	increased classified tumor incidence	0.01391	1.324	--	INHERITED FROM: increased B cell derived lymphoma incidence
Mammalian Phenotype (MP)	abnormal classified tumor incidence	0.01448	1.324	--	INHERITED FROM: increased B cell derived lymphoma incidence
Mammalian Phenotype (MP)	increased organ/body region tumor incidence	0.01782	1.223	--	INHERITED FROM: increased B cell derived lymphoma incidence || increased hemolymphoid system tumor incidence
Mammalian Phenotype (MP)	abnormal organ/body region tumor incidence	0.01952	1.223	--	INHERITED FROM: increased hemolymphoid system tumor incidence || increased B cell derived lymphoma incidence
Mammalian Phenotype (MP)	abnormal gametogenesis	0.0239	1.324	--	INHERITED FROM: arrest of male meiosis
Mammalian Phenotype (MP)	increased tumor incidence	0.03153	1.172	--	INHERITED FROM: increased B cell derived lymphoma incidence || increased hemolymphoid system tumor incidence
Mammalian Phenotype (MP)	increased lymphoma incidence	0.0418	1.649	--	INHERITED FROM: increased B cell derived lymphoma incidence
Mammalian Phenotype (MP)	abnormal tumor incidence	0.04973	1.141	--	INHERITED FROM: increased B cell derived lymphoma incidence || increased hemolymphoid system tumor incidence
Mammalian Phenotype (MP)	altered tumor susceptibility	0.05248	1.141	--	INHERITED FROM: increased B cell derived lymphoma incidence || increased hemolymphoid system tumor incidence
Mammalian Phenotype (MP)	reproductive system phenotype	0.07408	0.8397	--	INHERITED FROM: arrest of male meiosis
Mammalian Phenotype (MP)	abnormal cell physiology	0.0951	0.6209	--	INHERITED FROM: abnormal epigenetic regulation of gene expression
Mammalian Phenotype (MP)	embryonic lethality during organogenesis	0.2852	1.758	--	INHERITED FROM: embryonic lethality during organogenesis, complete penetrance
Mammalian Phenotype (MP)	embryonic lethality	0.3516	1.126	--	INHERITED FROM: embryonic lethality during organogenesis, complete penetrance
Mammalian Phenotype (MP)	mortality/aging	0.0004299	0.5424	Least Informative	DIRECT
Mammalian Phenotype (MP)	cellular phenotype	0.1797	0.5387	Least Informative	INHERITED FROM: abnormal epigenetic regulation of gene expression
Mammalian Phenotype (MP)	prenatal lethality	0.01747	0.9129	Moderately Informative	INHERITED FROM: embryonic lethality during organogenesis, complete penetrance
Mammalian Phenotype (MP)	neoplasm	0.0728	1.035	Moderately Informative	INHERITED FROM: increased hemolymphoid system tumor incidence || increased B cell derived lymphoma incidence
Mammalian Phenotype (MP)	abnormal reproductive system morphology	0.5485	0.9404	Moderately Informative	INHERITED FROM: arrest of male meiosis
Mammalian Phenotype (MP)	increased hemolymphoid system tumor incidence	0.0007239	1.603	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal spermatogenesis	0.821	1.489	Informative	INHERITED FROM: arrest of male meiosis
Mammalian Phenotype (MP)	embryonic lethality during organogenesis, complete penetrance	0.0004556	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	arrest of spermatogenesis	0.006171	2.126	Highly Informative	INHERITED FROM: arrest of male meiosis
Mammalian Phenotype (MP)	abnormal male meiosis	0.01525	2.001	Highly Informative	INHERITED FROM: arrest of male meiosis

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	protein methylation variant	0	2.468	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	histone methylation variant	0	2.769	--	DIRECT
Worm Phenotype (WP)	maternal effect sterile	0.000000000001554	2.769	--	DIRECT
Worm Phenotype (WP)	transgenerational loss of fertility	0.00000002006	2.769	--	DIRECT
Worm Phenotype (WP)	RNAi response variant	0.00000009153	1.769	--	DIRECT
Worm Phenotype (WP)	protein modification variant	0.0000002326	1.769	--	DIRECT
Worm Phenotype (WP)	vulval cell induction increased	0.000004569	1.866	--	DIRECT
Worm Phenotype (WP)	vulval cell induction variant	0.00001247	1.727	--	DIRECT
Worm Phenotype (WP)	fewer germ cells	0.00001293	2.769	--	DIRECT
Worm Phenotype (WP)	gene expression variant	0.00004426	0.6256	--	DIRECT
Worm Phenotype (WP)	mRNA expression variant	0.000274	1.814	--	DIRECT
Worm Phenotype (WP)	cell number variant	0.0003047	1.371	--	DIRECT
Worm Phenotype (WP)	ectopic expression antibody	0.0009262	2.769	--	DIRECT
Worm Phenotype (WP)	metabolic pathway variant	0.0009902	1.263	--	DIRECT
Worm Phenotype (WP)	programmed cell death variant	0.001031	1.087	--	INHERITED FROM: apoptosis increased
Worm Phenotype (WP)	reproductive system development variant	0.03292	1.156	--	INHERITED FROM: vulval cell induction variant || vulval cell induction increased || multivulva
Worm Phenotype (WP)	vulva cell fate specification variant	0.05637	1.689	--	INHERITED FROM: multivulva || vulval cell induction increased || vulval cell induction variant
Worm Phenotype (WP)	organism physiology variant	0.2306	0.1342	--	INHERITED FROM: protein methylation variant || metabolic pathway variant || gene expression variant || ectopic expression antibody || life span variant || protein modification variant || maintenance of gene silencing variant || mRNA expression variant || RNAi response variant || pattern of transgene expression variant || organism metabolism processing variant || protein metabolism variant || histone methylation variant || shortened life span
Worm Phenotype (WP)	gametogenesis variant	0.3281	1.013	--	INHERITED FROM: fewer germ cells
Worm Phenotype (WP)	sterile progeny	0.5091	0.6547	--	INHERITED FROM: maternal effect sterile
Worm Phenotype (WP)	transgene expression variant	0.563	0.773	--	INHERITED FROM: pattern of transgene expression variant
Worm Phenotype (WP)	apoptosis variant	0.8102	1.125	--	INHERITED FROM: apoptosis increased
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: protein modification variant || hermaphrodite fertility variant || maternal effect sterile || organism metabolism processing variant || RNAi response variant || vulval cell induction increased || reproductive system physiology variant || metabolic pathway variant || cell fate specification variant || gene expression variant || maintenance of gene silencing variant || lethal || mRNA expression variant || transgenerational loss of fertility || life span variant || fewer germ cells || development variant || apoptosis increased || hermaphrodite sterile || hermaphrodite fertility reduced || multivulva || embryonic development variant || embryonic lethal || cell number variant || fertility variant || vulval cell induction variant || protein metabolism variant || pattern of transgene expression variant || shortened life span || histone methylation variant || organ system physiology variant || protein methylation variant || maternal sterile || organism development variant || ectopic expression antibody || fertility reduced
Worm Phenotype (WP)	organism homeostasis metabolism variant	1	0.1444	--	INHERITED FROM: gene expression variant || metabolic pathway variant || protein methylation variant || ectopic expression antibody || maintenance of gene silencing variant || protein modification variant || histone methylation variant || pattern of transgene expression variant || organism metabolism processing variant || protein metabolism variant || mRNA expression variant || RNAi response variant
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: maternal effect sterile || hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	organism metabolism processing variant	0.0002964	0.4899	Least Informative	DIRECT
Worm Phenotype (WP)	cell physiology variant	0.001316	0.5955	Least Informative	INHERITED FROM: protein modification variant || protein methylation variant || apoptosis increased || histone methylation variant || protein metabolism variant
Worm Phenotype (WP)	cell development variant	0.06242	0.6752	Least Informative	INHERITED FROM: vulval cell induction variant || cell fate specification variant || fewer germ cells || multivulva || vulval cell induction increased
Worm Phenotype (WP)	progeny variant	0.4498	0.6514	Least Informative	INHERITED FROM: maternal effect sterile
Worm Phenotype (WP)	pattern of transgene expression variant	0.00001176	0.9833	Moderately Informative	DIRECT
Worm Phenotype (WP)	protein expression variant	0.001891	1.125	Moderately Informative	INHERITED FROM: protein modification variant || histone methylation variant || ectopic expression antibody || protein methylation variant
Worm Phenotype (WP)	organ system development variant	0.004923	0.9113	Moderately Informative	INHERITED FROM: vulval cell induction variant || vulval cell induction increased || multivulva
Worm Phenotype (WP)	cell homeostasis metabolism variant	0.0304	1.036	Moderately Informative	INHERITED FROM: protein modification variant || protein metabolism variant || protein methylation variant || histone methylation variant
Worm Phenotype (WP)	cell death variant	0.056	1.061	Moderately Informative	INHERITED FROM: apoptosis increased
Worm Phenotype (WP)	germ cell development variant	0.07803	1.013	Moderately Informative	INHERITED FROM: fewer germ cells
Worm Phenotype (WP)	life span variant	0.0000000000005309	1.321	Informative	DIRECT
Worm Phenotype (WP)	protein metabolism variant	0.0000006947	1.354	Informative	DIRECT
Worm Phenotype (WP)	cell fate specification variant	0.00003472	1.513	Informative	DIRECT
Worm Phenotype (WP)	vulva development variant	0.00716	1.655	Informative	INHERITED FROM: multivulva || vulval cell induction increased || vulval cell induction variant
Worm Phenotype (WP)	RNA expression variant	0.05683	1.565	Informative	INHERITED FROM: mRNA expression variant
Worm Phenotype (WP)	apoptosis increased	0.000001217	1.866	Highly Informative	DIRECT
Worm Phenotype (WP)	multivulva	0.000003699	1.866	Highly Informative	DIRECT
Worm Phenotype (WP)	maintenance of gene silencing variant	0.0002693	1.866	Highly Informative	DIRECT
Worm Phenotype (WP)	shortened life span	0.0007257	1.814	Highly Informative	DIRECT
Worm Phenotype (WP)	germline proliferation variant	0.008904	2.07	Highly Informative	INHERITED FROM: fewer germ cells
Worm Phenotype (WP)	antibody staining variant	0.03917	2.07	Highly Informative	INHERITED FROM: ectopic expression antibody
Worm Phenotype (WP)	cell number decreased	0.1147	1.814	Highly Informative	INHERITED FROM: fewer germ cells

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.06546	--	DIRECT
Fly Phenotype (FP)	lethal - all die before end of pupal stage	0.0007181	1.239	--	DIRECT
Fly Phenotype (FP)	lethal	0.006015	0.678	--	INHERITED FROM: lethal - all die before end of pupal stage
Fly Phenotype (FP)	increased mortality during development	0.4342	0.6148	--	INHERITED FROM: lethal - all die before end of pupal stage
Fly Phenotype (FP)	increased mortality	0	0.5343	Least Informative	DIRECT
Fly Phenotype (FP)	visible	0.0001821	1.239	Moderately Informative	DIRECT
Fly Phenotype (FP)	lethal - all die before end of P-stage	0.03113	1.181	Moderately Informative	INHERITED FROM: lethal - all die before end of pupal stage
Fly Phenotype (FP)	modifier of variegation	0.00000015	1.687	Informative	DIRECT
Fly Phenotype (FP)	suppressor of variegation	0.00000001526	2.085	Highly Informative	DIRECT
Fly Phenotype (FP)	homeotic	0.00001821	1.784	Highly Informative	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	metathoracic leg	0.00007068	2.389	--	DIRECT
Fly Anatomy (FA)	haltere	0.00007518	2.389	--	DIRECT
Fly Anatomy (FA)	adult metathoracic segment	0.0009008	2.088	--	DIRECT
Fly Anatomy (FA)	larval thorax	0.003073	1.69	--	INHERITED FROM: dorsal thoracic disc
Fly Anatomy (FA)	larval imaginal tissue	0.005354	1.435	--	INHERITED FROM: dorsal thoracic disc
Fly Anatomy (FA)	imaginal tissue	0.02256	1.435	--	INHERITED FROM: dorsal thoracic disc
Fly Anatomy (FA)	thoracic segment	0.02597	0.912	--	INHERITED FROM: metathoracic leg || dorsal thoracic disc || haltere || adult metathoracic segment
Fly Anatomy (FA)	organism subdivision	0.07009	0.5027	--	INHERITED FROM: dorsal thoracic disc || adult metathoracic segment || haltere || metathoracic leg
Fly Anatomy (FA)	thorax	0.09759	0.912	--	INHERITED FROM: adult metathoracic segment || haltere || metathoracic leg || dorsal thoracic disc
Fly Anatomy (FA)	integumentary system	0.1704	0.8094	--	INHERITED FROM: metathoracic leg || haltere
Fly Anatomy (FA)	tagmatic subdivision of integument	0.1968	0.9742	--	INHERITED FROM: haltere || metathoracic leg
Fly Anatomy (FA)	region of integument	0.4341	0.884	--	INHERITED FROM: metathoracic leg || haltere
Fly Anatomy (FA)	organ system	0.4719	0.1823	--	INHERITED FROM: metathoracic leg || haltere
Fly Anatomy (FA)	adult tagma	0.5033	0.6649	--	INHERITED FROM: metathoracic leg || adult metathoracic segment || haltere
Fly Anatomy (FA)	adult integumentary system	0.5256	0.9578	--	INHERITED FROM: metathoracic leg || haltere
Fly Anatomy (FA)	adult thorax	0.61	0.942	--	INHERITED FROM: adult metathoracic segment || haltere || metathoracic leg
Fly Anatomy (FA)	adult thoracic segment	0.6844	0.942	--	INHERITED FROM: metathoracic leg || haltere || adult metathoracic segment
Fly Anatomy (FA)	adult segment	0.7236	0.821	--	INHERITED FROM: metathoracic leg || haltere || adult metathoracic segment
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || adult metathoracic segment || dorsal thoracic disc || haltere || metathoracic leg || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: multicellular structure || metathoracic leg || haltere || dorsal thoracic disc || organism || adult metathoracic segment
Fly Anatomy (FA)	anterior-posterior subdivision of organism	1	0.5027	--	INHERITED FROM: adult metathoracic segment || dorsal thoracic disc || metathoracic leg || haltere
Fly Anatomy (FA)	tagma	0.08272	0.5027	Least Informative	INHERITED FROM: dorsal thoracic disc || adult metathoracic segment || haltere || metathoracic leg
Fly Anatomy (FA)	organ system subdivision	0.09608	0.4301	Least Informative	INHERITED FROM: metathoracic leg || haltere
Fly Anatomy (FA)	adult	0.09628	0.4496	Least Informative	INHERITED FROM: adult metathoracic segment || metathoracic leg || haltere
Fly Anatomy (FA)	multi-tissue structure	0.1656	0.6038	Least Informative	INHERITED FROM: dorsal thoracic disc
Fly Anatomy (FA)	segment	0.2901	0.6568	Least Informative	INHERITED FROM: adult metathoracic segment || dorsal thoracic disc || metathoracic leg || haltere
Fly Anatomy (FA)	larva	0.4927	0.3763	Least Informative	INHERITED FROM: dorsal thoracic disc
Fly Anatomy (FA)	larval segment	0.008214	1.243	Moderately Informative	INHERITED FROM: dorsal thoracic disc
Fly Anatomy (FA)	larval tagma	0.04895	1.159	Moderately Informative	INHERITED FROM: dorsal thoracic disc
Fly Anatomy (FA)	developing material anatomical entity	0.05641	0.8329	Moderately Informative	INHERITED FROM: dorsal thoracic disc
Fly Anatomy (FA)	adult external thorax	0.1574	1.009	Moderately Informative	INHERITED FROM: haltere || metathoracic leg
Fly Anatomy (FA)	appendage	0.395	1.047	Moderately Informative	INHERITED FROM: metathoracic leg || haltere
Fly Anatomy (FA)	larval thoracic segment	0.004879	1.69	Informative	INHERITED FROM: dorsal thoracic disc
Fly Anatomy (FA)	imaginal disc	0.007297	1.435	Informative	INHERITED FROM: dorsal thoracic disc
Fly Anatomy (FA)	leg	0.02113	1.486	Informative	INHERITED FROM: metathoracic leg
Fly Anatomy (FA)	dorsal thoracic disc	0.0002013	1.912	Highly Informative	DIRECT
Fly Anatomy (FA)	metathoracic segment	0.01477	1.912	Highly Informative	INHERITED FROM: metathoracic leg || adult metathoracic segment || haltere

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	compound organ	0	0.4299	--	DIRECT
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.1857	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1532	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: anatomical system || anatomical group || whole organism || compound organ || cavitated compound organ
Zebrafish Anatomy (ZA)	cavitated compound organ	0	0.5123	Least Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	head region	0	0.4759	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	primary germ layer	0.0007048	0.6748	--	DIRECT
Xenopus ANatomical entity (XAN)	central nervous system	0.01211	0.5841	--	INHERITED FROM: hindbrain
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: hindbrain
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: head region || hindbrain || anatomical group || cavitated compound organ || multicellular anatomical structure || compound organ || anatomical region || organism subdivision || head || primary germ layer
Xenopus ANatomical entity (XAN)	head	0	0.4777	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.2685	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	embryo	0.001317	0.5979	Least Informative	INHERITED FROM: primary germ layer
Xenopus ANatomical entity (XAN)	tissue	0.02852	0.4672	Least Informative	INHERITED FROM: primary germ layer
Xenopus ANatomical entity (XAN)	nervous system	0.03092	0.5619	Least Informative	INHERITED FROM: hindbrain
Xenopus ANatomical entity (XAN)	multi-tissue structure	0.01955	1.066	Moderately Informative	INHERITED FROM: hindbrain
Xenopus ANatomical entity (XAN)	brain	0.05956	0.7859	Moderately Informative	INHERITED FROM: hindbrain
Xenopus ANatomical entity (XAN)	hindbrain	0.000635	1.824	Highly Informative	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || shoot system
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: shoot system

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	[Histone H3]-lysine(4) N-trimethyltransferase	0	2.628	--	DIRECT
Enzyme Commission (EC)	[Histone H3]-lysine(9) N-trimethyltransferase	0	2.929	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0.3972	Least Informative	DIRECT
Enzyme Commission (EC)	Transferring one-carbon groups	0	1.161	Moderately Informative	DIRECT
Enzyme Commission (EC)	Methyltransferases	0	1.257	Informative	DIRECT

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