Group II chaperonin (CCT, TRIC), ATPase domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All alpha proteins [ 46456] (284)
• Fold: GroEL equatorial domain-like [ 48591]
• Superfamily: GroEL equatorial domain-like [ 48592] (2)
• Family: Group II chaperonin (CCT, TRIC), ATPase domain [ 48596]

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Family statistics

	Genomes (191)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	385	2,333	5
Proteins	385	2,333	5

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	growth variant	0	0.3438	--	DIRECT
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	transgene expression variant	0	0.773	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	cell morphology variant	0	0.7558	--	DIRECT
Worm Phenotype (WP)	organ system morphology variant	0	0.7516	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	gene expression variant	0	0.6256	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	larval development variant	0	0.4322	--	DIRECT
Worm Phenotype (WP)	gametogenesis variant	0	1.013	--	DIRECT
Worm Phenotype (WP)	developmental growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	larval growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	gonad morphology variant	0	1.306	--	DIRECT
Worm Phenotype (WP)	protein interaction variant	0	1.078	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	cell component morphology variant	0	0.8392	--	DIRECT
Worm Phenotype (WP)	meiotic progression prophase variant	0.00000000001355	1.407	--	DIRECT
Worm Phenotype (WP)	meiotic progression during oogenesis variant	0.00000000004619	1.321	--	DIRECT
Worm Phenotype (WP)	germ cell compartment morphology variant	0.0000000000819	1.354	--	DIRECT
Worm Phenotype (WP)	recycling endosome localization variant	0.000000006983	1.769	--	DIRECT
Worm Phenotype (WP)	endosome localization variant	0.000000007566	1.769	--	DIRECT
Worm Phenotype (WP)	germ cell morphology variant	0.00000002925	1.156	--	DIRECT
Worm Phenotype (WP)	recycling endosome morphology variant	0.0000000499	1.727	--	DIRECT
Worm Phenotype (WP)	receptor mediated endocytosis defective	0.00000005247	1.689	--	DIRECT
Worm Phenotype (WP)	protein aggregation variant	0.00000005822	1.087	--	DIRECT
Worm Phenotype (WP)	endosome morphology variant	0.00000006249	1.727	--	DIRECT
Worm Phenotype (WP)	oocyte physiology variant	0.00000006728	1.593	--	DIRECT
Worm Phenotype (WP)	vesicle morphology variant	0.0000001034	1.689	--	DIRECT
Worm Phenotype (WP)	sexually dimorphic physiology variant	0.0000002217	1.426	--	DIRECT
Worm Phenotype (WP)	pigmentation variant	0.0000003726	1.924	--	DIRECT
Worm Phenotype (WP)	protruding vulva	0.0000004031	1.623	--	DIRECT
Worm Phenotype (WP)	endocytic transport variant	0.0000005145	1.354	--	DIRECT
Worm Phenotype (WP)	apoptosis variant	0.0000007061	1.125	--	DIRECT
Worm Phenotype (WP)	programmed cell death variant	0.000001076	1.087	--	DIRECT
Worm Phenotype (WP)	accumulated cell corpses	0.00001365	1.371	--	DIRECT
Worm Phenotype (WP)	male gonad development variant	0.00002337	1.924	--	DIRECT
Worm Phenotype (WP)	other abnormality early emb	0.0000561	1.99	--	DIRECT
Worm Phenotype (WP)	pathogen induced antimicrobial gene expression variant	0.0001151	1.814	--	DIRECT
Worm Phenotype (WP)	innate immune response variant	0.0001261	1.814	--	DIRECT
Worm Phenotype (WP)	behavior variant	0.0002242	0.6859	--	DIRECT
Worm Phenotype (WP)	response to bacteria variant	0.0002721	1.426	--	DIRECT
Worm Phenotype (WP)	pachytene region organization variant	0.000282	1.727	--	DIRECT
Worm Phenotype (WP)	vesicle trafficking variant	0.0003044	1.354	--	DIRECT
Worm Phenotype (WP)	somatic gonad development variant	0.0003393	1.655	--	DIRECT
Worm Phenotype (WP)	diakinesis region organization variant	0.0007741	2.292	--	DIRECT
Worm Phenotype (WP)	feeding behavior variant	0.001895	1.25	--	INHERITED FROM: avoids bacterial lawn
Worm Phenotype (WP)	meiosis variant	0.00305	1.263	--	INHERITED FROM: pachytene progression during oogenesis variant || meiotic progression prophase variant || pachytene region organization variant || chromosome condensation variant || diakinesis region organization variant
Worm Phenotype (WP)	oogenesis variant	0.004181	1.237	--	INHERITED FROM: pachytene progression during oogenesis variant || meiotic progression during oogenesis variant || pachytene region organization variant || meiotic progression prophase variant || diakinesis region organization variant
Worm Phenotype (WP)	antimicrobial gene expression variant	0.00502	1.814	--	INHERITED FROM: no induction of antimicrobial peptide expression after infection || pathogen induced antimicrobial gene expression variant
Worm Phenotype (WP)	pathogen induced gene expression variant	0.005181	1.814	--	INHERITED FROM: pathogen induced antimicrobial gene expression variant || no induction of antimicrobial peptide expression after infection
Worm Phenotype (WP)	metabolic pathway variant	0.02115	1.263	--	INHERITED FROM: unfolded protein response variant || protein metabolism variant
Worm Phenotype (WP)	organelle organization biogenesis variant	0.125	1.306	--	INHERITED FROM: germline nuclear positioning variant || nuclear positioning variant
Worm Phenotype (WP)	reproductive system development variant	0.1579	1.156	--	INHERITED FROM: male gonad development variant || gonad development variant || male somatic gonad development variant || somatic gonad development variant
Worm Phenotype (WP)	no germ line	0.1851	1.814	--	INHERITED FROM: no oocytes
Worm Phenotype (WP)	cell corpse number variant	0.1908	1.306	--	INHERITED FROM: accumulated cell corpses || accumulated germline cell corpses
Worm Phenotype (WP)	hermaphrodite reproductive system morphology variant	0.2555	1.426	--	INHERITED FROM: protruding vulva || vulva morphology variant
Worm Phenotype (WP)	germ cell compartment nuclei number variant	0.262	1.814	--	INHERITED FROM: germ cell compartment anucleate
Worm Phenotype (WP)	somatic gonad morphology variant	0.3206	1.866	--	INHERITED FROM: gonad arm morphology variant
Worm Phenotype (WP)	no differentiated gametes	0.5046	1.814	--	INHERITED FROM: no oocytes
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: meiotic progression during oogenesis variant || developmental growth variant || unfolded protein response variant || organism metabolism processing variant || somatic gonad development variant || vesicle morphology variant || response to bacteria variant || reproductive system physiology variant || pleiotropic defects severe early emb || transgene expression variant || gene expression variant || early embryonic lethal || endocytic transport variant || no oocytes || extended life span || organism homeostasis metabolism variant || apoptosis variant || diakinesis region organization variant || avoids bacterial lawn || lethal || larval development variant || chromosome condensation variant || protein interaction variant || germ cell physiology variant || organism physiology variant || innate immune response variant || germ cell development variant || oocyte physiology variant || germ cell differentiation variant || sexually dimorphic physiology variant || male gonad development variant || cell division variant || endocytic transport defect || development variant || nuclear positioning variant || accumulated germline cell corpses || male somatic gonad development variant || cell physiology variant || organism environmental stimulus response variant || growth variant || no induction of antimicrobial peptide expression after infection || sick || cell death variant || accumulated cell corpses || embryonic development variant || embryonic lethal || larval growth variant || germline nuclear positioning variant || vesicle organization variant || fertility variant || behavior variant || other abnormality early emb || protein metabolism variant || pattern of transgene expression variant || protein aggregation variant || gametogenesis variant || recycling endosome morphology variant || cell cycle variant || pachytene progression during oogenesis variant || meiotic progression prophase variant || postembryonic development variant || gonad development variant || larval arrest || organ system physiology variant || organism behavior variant || endosome morphology variant || organism heat response variant || pathogen induced antimicrobial gene expression variant || organism development variant || programmed cell death variant || vesicle trafficking variant || level of transgene expression variant || hermaphrodite physiology variant || receptor mediated endocytosis defective || fertility reduced || transgene expression increased || pachytene region organization variant || cell development variant
Worm Phenotype (WP)	organism metabolism processing variant	0	0.4899	Least Informative	DIRECT
Worm Phenotype (WP)	larval arrest	0	0.4991	Least Informative	DIRECT
Worm Phenotype (WP)	cell development variant	0	0.6752	Least Informative	DIRECT
Worm Phenotype (WP)	cell physiology variant	0.0001449	0.5955	Least Informative	DIRECT
Worm Phenotype (WP)	organism behavior variant	0.0002172	0.6859	Least Informative	DIRECT
Worm Phenotype (WP)	organism environmental stimulus response variant	0.0002614	0.6614	Least Informative	DIRECT
Worm Phenotype (WP)	reproductive system morphology variant	0	1.078	Moderately Informative	DIRECT
Worm Phenotype (WP)	germ cell development variant	0	1.013	Moderately Informative	DIRECT
Worm Phenotype (WP)	germ cell differentiation variant	0	1.167	Moderately Informative	DIRECT
Worm Phenotype (WP)	pattern of transgene expression variant	0	0.9833	Moderately Informative	DIRECT
Worm Phenotype (WP)	level of transgene expression variant	0	1.125	Moderately Informative	DIRECT
Worm Phenotype (WP)	early embryonic lethal	0	1.178	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell organization biogenesis variant	0	1.135	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell cycle variant	0.000000004692	1.225	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell division variant	0.00000008248	1.036	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell death variant	0.0008052	1.061	Moderately Informative	DIRECT
Worm Phenotype (WP)	organ system development variant	0.007103	0.9113	Moderately Informative	INHERITED FROM: somatic gonad development variant || gonad development variant || male somatic gonad development variant || male gonad development variant
Worm Phenotype (WP)	organism stress response variant	0.04798	0.9693	Moderately Informative	INHERITED FROM: unfolded protein response variant || innate immune response variant || organism heat response variant || no induction of antimicrobial peptide expression after infection || pathogen induced antimicrobial gene expression variant
Worm Phenotype (WP)	cell type morphology variant	0.1832	0.8878	Moderately Informative	INHERITED FROM: germ cell morphology variant || oocytes small || oocyte morphology variant || germ cell compartment morphology variant || germ cell compartment expansion variant || germ cell compartment anucleate
Worm Phenotype (WP)	cell homeostasis metabolism variant	0.2406	1.036	Moderately Informative	INHERITED FROM: unfolded protein response variant || protein metabolism variant
Worm Phenotype (WP)	chemical response variant	0.4659	0.9053	Moderately Informative	INHERITED FROM: unfolded protein response variant
Worm Phenotype (WP)	protein protein interaction variant	0.9893	1.078	Moderately Informative	INHERITED FROM: protein aggregation variant
Worm Phenotype (WP)	transgene expression increased	0	1.426	Informative	DIRECT
Worm Phenotype (WP)	pachytene progression during oogenesis variant	0.000000000001125	1.565	Informative	DIRECT
Worm Phenotype (WP)	germ cell compartment expansion variant	0.00000000001439	1.468	Informative	DIRECT
Worm Phenotype (WP)	oocyte morphology variant	0.0000000003913	1.292	Informative	DIRECT
Worm Phenotype (WP)	hermaphrodite physiology variant	0.0000000954	1.446	Informative	DIRECT
Worm Phenotype (WP)	vesicle organization variant	0.0000001231	1.655	Informative	DIRECT
Worm Phenotype (WP)	germ cell physiology variant	0.0000003199	1.49	Informative	DIRECT
Worm Phenotype (WP)	avoids bacterial lawn	0.0000004325	1.49	Informative	DIRECT
Worm Phenotype (WP)	endocytic transport defect	0.0000004504	1.407	Informative	DIRECT
Worm Phenotype (WP)	vulva morphology variant	0.0000009238	1.426	Informative	DIRECT
Worm Phenotype (WP)	nuclear positioning variant	0.000002248	1.623	Informative	DIRECT
Worm Phenotype (WP)	accumulated germline cell corpses	0.000005517	1.513	Informative	DIRECT
Worm Phenotype (WP)	protein metabolism variant	0.0001177	1.354	Informative	DIRECT
Worm Phenotype (WP)	sick	0.0001801	1.727	Informative	DIRECT
Worm Phenotype (WP)	gonad development variant	0.0006808	1.538	Informative	DIRECT
Worm Phenotype (WP)	cell stress response variant	0.001208	1.538	Informative	INHERITED FROM: unfolded protein response variant
Worm Phenotype (WP)	cell component localization variant	0.001333	1.388	Informative	INHERITED FROM: endosome localization variant || recycling endosome localization variant || RAB-11 recycling endosome localization variant
Worm Phenotype (WP)	life span variant	0.002492	1.321	Informative	INHERITED FROM: extended life span
Worm Phenotype (WP)	organism temperature response variant	0.002944	1.593	Informative	INHERITED FROM: organism heat response variant
Worm Phenotype (WP)	rachis morphology variant	0.09307	1.623	Informative	INHERITED FROM: rachis narrow
Worm Phenotype (WP)	mitosis variant	0.1112	1.689	Informative	INHERITED FROM: chromosome condensation variant
Worm Phenotype (WP)	organism pathogen response variant	0.287	1.468	Informative	INHERITED FROM: no induction of antimicrobial peptide expression after infection || innate immune response variant || pathogen induced antimicrobial gene expression variant
Worm Phenotype (WP)	meiotic chromosome organization variant	0.6993	1.623	Informative	INHERITED FROM: chromosome condensation variant
Worm Phenotype (WP)	oocytes small	0.000000000000001565	2.07	Highly Informative	DIRECT
Worm Phenotype (WP)	pleiotropic defects severe early emb	0.00000000000115	1.99	Highly Informative	DIRECT
Worm Phenotype (WP)	germline nuclear positioning variant	0.00000000007684	1.769	Highly Informative	DIRECT
Worm Phenotype (WP)	rachis narrow	0.0000000001819	1.866	Highly Informative	DIRECT
Worm Phenotype (WP)	RAB-11 recycling endosome localization variant	0.000000006706	1.769	Highly Informative	DIRECT
Worm Phenotype (WP)	unfolded protein response variant	0.00000002117	2.07	Highly Informative	DIRECT
Worm Phenotype (WP)	germ cell compartment anucleate	0.00000003512	1.924	Highly Informative	DIRECT
Worm Phenotype (WP)	organism heat response variant	0.00000007634	1.99	Highly Informative	DIRECT
Worm Phenotype (WP)	organism pigmentation variant	0.0000002261	1.924	Highly Informative	DIRECT
Worm Phenotype (WP)	extended life span	0.000005184	1.814	Highly Informative	DIRECT
Worm Phenotype (WP)	male somatic gonad development variant	0.00001555	2.07	Highly Informative	DIRECT
Worm Phenotype (WP)	gonad arm morphology variant	0.00002806	1.866	Highly Informative	DIRECT
Worm Phenotype (WP)	chromosome condensation variant	0.00003381	1.866	Highly Informative	DIRECT
Worm Phenotype (WP)	no induction of antimicrobial peptide expression after infection	0.00007301	1.99	Highly Informative	DIRECT
Worm Phenotype (WP)	no oocytes	0.000113	1.814	Highly Informative	DIRECT
Worm Phenotype (WP)	cell membrane organization biogenesis variant	0.0002525	1.814	Highly Informative	DIRECT
Worm Phenotype (WP)	diakinesis progression during oogenesis variant	0.1559	2.167	Highly Informative	INHERITED FROM: diakinesis region organization variant

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.09186	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0	0.1452	--	DIRECT
Yeast Phenotype (YP)	competitive fitness	0	0.1116	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1096	--	DIRECT

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.06546	--	DIRECT
Fly Phenotype (FP)	visible	0	1.239	Moderately Informative	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	head	0	0.912	--	DIRECT
Fly Anatomy (FA)	adult tagma	0	0.6649	--	DIRECT
Fly Anatomy (FA)	organism subdivision	0	0.5027	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	adult dorsal vessel	0.0000000000239	1.611	--	DIRECT
Fly Anatomy (FA)	adult circulatory system	0.0000000005066	1.611	--	DIRECT
Fly Anatomy (FA)	organ system	0.5211	0.1823	--	INHERITED FROM: circulatory system || adult heart || adult circulatory system || adult dorsal vessel
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || adult || adult dorsal vessel || adult head || adult circulatory system || adult heart || circulatory system || adult tagma || tagma || head || organism subdivision || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: organism subdivision || multicellular structure || circulatory system || adult tagma || tagma || head || adult heart || adult head || adult circulatory system || adult || adult dorsal vessel || organism
Fly Anatomy (FA)	anterior-posterior subdivision of organism	1	0.5027	--	INHERITED FROM: head || tagma || adult tagma || adult head
Fly Anatomy (FA)	tagma	0	0.5027	Least Informative	DIRECT
Fly Anatomy (FA)	adult	0	0.4496	Least Informative	DIRECT
Fly Anatomy (FA)	multi-tissue structure	0.06016	0.6038	Least Informative	INHERITED FROM: adult heart || adult dorsal vessel
Fly Anatomy (FA)	adult head	0	1.009	Moderately Informative	DIRECT
Fly Anatomy (FA)	circulatory system	0.000009252	1.243	Moderately Informative	DIRECT
Fly Anatomy (FA)	adult heart	0.00000000002076	1.611	Informative	DIRECT

---

Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.1857	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1532	--	DIRECT
Zebrafish Anatomy (ZA)	trunk musculature	0.0000001011	1.772	--	DIRECT
Zebrafish Anatomy (ZA)	skeletal muscle cell	0.000000118	1.693	--	DIRECT
Zebrafish Anatomy (ZA)	striated muscle cell	0.000001764	1.568	--	DIRECT
Zebrafish Anatomy (ZA)	muscle	0.00004185	1.43	--	DIRECT
Zebrafish Anatomy (ZA)	musculature system	0.00008974	1.325	--	DIRECT
Zebrafish Anatomy (ZA)	liver	0.0003302	2.17	--	DIRECT
Zebrafish Anatomy (ZA)	compound organ	0.7027	0.4299	--	INHERITED FROM: solid compound organ || liver
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: skeletal muscle || trunk musculature || anatomical system || solid compound organ || myotome || liver and biliary system || anatomical group || gut || liver || whole organism || muscle cell || skeletal muscle cell || musculature system || muscle || striated muscle cell
Zebrafish Anatomy (ZA)	electrically responsive cell	1	1.216	--	INHERITED FROM: striated muscle cell || skeletal muscle cell || muscle cell
Zebrafish Anatomy (ZA)	cell	0.1125	0.6388	Least Informative	INHERITED FROM: skeletal muscle cell || muscle cell || striated muscle cell
Zebrafish Anatomy (ZA)	electrically active cell	0.002363	1.17	Moderately Informative	INHERITED FROM: muscle cell || skeletal muscle cell || striated muscle cell
Zebrafish Anatomy (ZA)	portion of tissue	0.07756	0.7637	Moderately Informative	INHERITED FROM: myotome || striated muscle cell || muscle || muscle cell || skeletal muscle cell || skeletal muscle
Zebrafish Anatomy (ZA)	skeletal muscle	0.0000003453	1.626	Informative	DIRECT
Zebrafish Anatomy (ZA)	muscle cell	0.000004078	1.471	Informative	DIRECT
Zebrafish Anatomy (ZA)	digestive system	0.01988	1.517	Informative	INHERITED FROM: gut || liver
Zebrafish Anatomy (ZA)	myotome	0.00000003843	1.994	Highly Informative	DIRECT
Zebrafish Anatomy (ZA)	solid compound organ	0.0003302	1.994	Highly Informative	DIRECT
Zebrafish Anatomy (ZA)	liver and biliary system	0.0005888	2.17	Highly Informative	DIRECT
Zebrafish Anatomy (ZA)	gut	0.0007765	1.994	Highly Informative	DIRECT

---

Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	skeletal muscle	0.0000393	1.61	--	DIRECT
Xenopus ANatomical entity (XAN)	immune system	0.00009263	1.786	--	DIRECT
Xenopus ANatomical entity (XAN)	muscular system	0.0003236	1.263	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0.6914	0.2177	--	INHERITED FROM: thymus
Xenopus ANatomical entity (XAN)	anatomical region	0.7795	0.1803	--	INHERITED FROM: tail region || tail
Xenopus ANatomical entity (XAN)	organism subdivision	0.8166	0.1679	--	INHERITED FROM: tail
Xenopus ANatomical entity (XAN)	anatomical group	0.8501	0.1408	--	INHERITED FROM: muscular system || muscle || thymus || immune system || endocrine system || skeletal muscle
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0.9266	0.1131	--	INHERITED FROM: muscle || thymus || tail || skeletal muscle
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: muscular system || muscle || thymus || immune system || endocrine system || skeletal muscle
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: tail region || immune system || endocrine system || muscle || muscular system || thymus || tail || skeletal muscle
Xenopus ANatomical entity (XAN)	tissue	0.207	0.4672	Least Informative	INHERITED FROM: skeletal muscle || muscle
Xenopus ANatomical entity (XAN)	tail region	0.0008639	1.242	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	musculoskeletal system	0.002712	1.087	Moderately Informative	INHERITED FROM: muscular system || muscle || skeletal muscle
Xenopus ANatomical entity (XAN)	muscle	0.00005946	1.45	Informative	DIRECT
Xenopus ANatomical entity (XAN)	endocrine system	0.0001598	1.719	Informative	DIRECT
Xenopus ANatomical entity (XAN)	tail	0.0004972	1.334	Informative	DIRECT
Xenopus ANatomical entity (XAN)	thymus	0.00008806	1.824	Highly Informative	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

---

Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	whole plant	0	0.3507	--	DIRECT
Plant ANatomical entity (PAN)	cauline leaf	0	0.6042	--	DIRECT
Plant ANatomical entity (PAN)	inflorescence meristem	0	0.6337	--	DIRECT
Plant ANatomical entity (PAN)	guard cell	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	stomatal complex	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	epidermal cell	0	0.2152	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2046	--	DIRECT
Plant ANatomical entity (PAN)	phyllome	0	0.3234	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2224	--	DIRECT
Plant ANatomical entity (PAN)	leaf lamina base	0	0.6245	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1621	--	DIRECT
Plant ANatomical entity (PAN)	plant organ	0	0.2391	--	DIRECT
Plant ANatomical entity (PAN)	sporophyll	0	0.3985	--	DIRECT
Plant ANatomical entity (PAN)	stamen	0	0.5171	--	DIRECT
Plant ANatomical entity (PAN)	carpel	0	0.5117	--	DIRECT
Plant ANatomical entity (PAN)	flower	0	0.3446	--	DIRECT
Plant ANatomical entity (PAN)	pedicel	0	0.5373	--	DIRECT
Plant ANatomical entity (PAN)	perianth	0	0.4476	--	DIRECT
Plant ANatomical entity (PAN)	corolla	0	0.4893	--	DIRECT
Plant ANatomical entity (PAN)	calyx	0	0.4728	--	DIRECT
Plant ANatomical entity (PAN)	inflorescence branch	0	0.5373	--	DIRECT
Plant ANatomical entity (PAN)	cotyledon	0	0.6432	--	DIRECT
Plant ANatomical entity (PAN)	petiole	0	0.6385	--	DIRECT
Plant ANatomical entity (PAN)	inflorescence axis	0	0.5373	--	DIRECT
Plant ANatomical entity (PAN)	leaf apex	0	0.5999	--	DIRECT
Plant ANatomical entity (PAN)	stem internode	0	0.5373	--	DIRECT
Plant ANatomical entity (PAN)	cardinal organ part	0	0.4385	--	DIRECT
Plant ANatomical entity (PAN)	plant axis	0	0.3257	--	DIRECT
Plant ANatomical entity (PAN)	collective phyllome structure	0	0.3837	--	DIRECT
Plant ANatomical entity (PAN)	root system	0	0.4584	--	DIRECT
Plant ANatomical entity (PAN)	shoot axis	0	0.3985	--	DIRECT
Plant ANatomical entity (PAN)	leaf	0	0.4282	--	DIRECT
Plant ANatomical entity (PAN)	lamina	0	0.6199	--	DIRECT
Plant ANatomical entity (PAN)	reproductive shoot system	0	0.3304	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.227	--	DIRECT
Plant ANatomical entity (PAN)	microsporangium	0	0.6705	--	DIRECT
Plant ANatomical entity (PAN)	pollen sac	0	0.673	--	DIRECT
Plant ANatomical entity (PAN)	pollen	0	0.673	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2335	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	cardinal part of multi-tissue plant structure	0	0.437	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: perianth || root || sporophyll || calyx || inflorescence axis || flower || lamina || collective plant structure || plant embryo || leaf || shoot internode || phyllome || pollen sac || cardinal organ part || multi-tissue plant structure || microsporophyll || guard cell || megasporophyll || cauline leaf || reproductive shoot system || shoot apex || leaf apex || leaf lamina base || branch || collective leaf structure || stem internode || inflorescence branch || shoot system || sporangium || portion of plant tissue || stomatal complex || plant organ || portion of meristem tissue || stem || whole plant || inflorescence meristem || epidermis || root system || inflorescence || cardinal part of multi-tissue plant structure || petiole || stalk || gynoecium || vascular leaf || sepal || microsporangium || epidermal cell || leaf lamina || shoot epidermal cell || corolla || pollen || plant axis || collective phyllome structure || petal || plant cell || carpel || seed || shoot epidermis || phyllome apex || cotyledon || stamen || shoot axis || microgametophyte || pedicel || androecium
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: inflorescence axis || calyx || flower || sporophyll || inflorescence meristem || root system || inflorescence || root || perianth || stem || leaf || phyllome || shoot internode || sepal || vascular leaf || gynoecium || petiole || petal || reproductive shoot system || shoot apex || leaf apex || carpel || collective phyllome structure || guard cell || megasporophyll || cauline leaf || pollen || microsporophyll || pollen sac || leaf lamina || shoot epidermal cell || corolla || pedicel || androecium || stomatal complex || phyllome apex || cotyledon || stamen || stem internode || inflorescence branch || shoot axis || shoot system || leaf lamina base || collective leaf structure || branch || shoot epidermis
Plant ANatomical entity (PAN)	phyllome lamina	1	0.6199	--	INHERITED FROM: leaf lamina base || leaf lamina
Plant ANatomical entity (PAN)	organ lamina	1	0.6199	--	INHERITED FROM: leaf lamina base || leaf lamina
Plant ANatomical entity (PAN)	shoot apex	0	0.481	Least Informative	DIRECT
Plant ANatomical entity (PAN)	shoot internode	0	0.5373	Least Informative	DIRECT
Plant ANatomical entity (PAN)	root	0	0.4679	Least Informative	DIRECT
Plant ANatomical entity (PAN)	plant embryo	0	0.4978	Least Informative	DIRECT
Plant ANatomical entity (PAN)	seed	0	0.5189	Least Informative	DIRECT
Plant ANatomical entity (PAN)	portion of meristem tissue	0	0.5892	Least Informative	DIRECT
Plant ANatomical entity (PAN)	vascular leaf	0	0.437	Least Informative	DIRECT
Plant ANatomical entity (PAN)	megasporophyll	0	0.5117	Least Informative	DIRECT
Plant ANatomical entity (PAN)	microsporophyll	0	0.4415	Least Informative	DIRECT
Plant ANatomical entity (PAN)	sepal	0	0.4728	Least Informative	DIRECT
Plant ANatomical entity (PAN)	petal	0	0.4893	Least Informative	DIRECT
Plant ANatomical entity (PAN)	stem	0	0.4777	Least Informative	DIRECT
Plant ANatomical entity (PAN)	inflorescence	0	0.4859	Least Informative	DIRECT
Plant ANatomical entity (PAN)	androecium	0	0.5153	Least Informative	DIRECT
Plant ANatomical entity (PAN)	gynoecium	0	0.5082	Least Informative	DIRECT
Plant ANatomical entity (PAN)	leaf lamina	0	0.6199	Least Informative	DIRECT
Plant ANatomical entity (PAN)	collective leaf structure	0	0.46	Least Informative	DIRECT
Plant ANatomical entity (PAN)	stalk	0	0.6176	Least Informative	DIRECT
Plant ANatomical entity (PAN)	branch	0	0.5373	Least Informative	DIRECT
Plant ANatomical entity (PAN)	sporangium	0	0.6679	Least Informative	DIRECT
Plant ANatomical entity (PAN)	phyllome apex	0	0.5956	Least Informative	DIRECT
Plant ANatomical entity (PAN)	microgametophyte	0	0.673	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	whole plant development stage	0	0.1547	--	DIRECT
Plant structure DEvelopment stage (PDE)	1 main shoot growth stage	0	0.3245	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0	0.1593	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1484	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.1648	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant embryo stage	0	0.2319	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	phyllome development stage	0	0.3879	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	leaf development stage	1	0.3879	--	INHERITED FROM: 4 leaf senescence stage
Plant structure DEvelopment stage (PDE)	leaf production stage	1	0.3272	--	INHERITED FROM: LP.02 two leaves visible stage || LP.10 ten leaves visible stage || LP.04 four leaves visible stage || LP.08 eight leaves visible stage || LP.12 twelve leaves visible stage || LP.06 six leaves visible stage
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: corolla development stage || flowering stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.1584	--	INHERITED FROM: sporophyte vegetative stage || C globular stage || LP.10 ten leaves visible stage || E expanded cotyledon stage || LP.12 twelve leaves visible stage || F mature embryo stage || LP.04 four leaves visible stage || D bilateral stage || LP.06 six leaves visible stage || LP.08 eight leaves visible stage || LP.02 two leaves visible stage || plant embryo stage || 1 main shoot growth stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: phyllome development stage || reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || flowering stage || corolla development stage || plant organ development stage || 4 leaf senescence stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.1584	--	INHERITED FROM: LP.08 eight leaves visible stage || LP.12 twelve leaves visible stage || E expanded cotyledon stage || LP.10 ten leaves visible stage || LP.06 six leaves visible stage || sporophyte vegetative stage || C globular stage || 1 main shoot growth stage || D bilateral stage || F mature embryo stage || LP.04 four leaves visible stage || plant embryo stage || LP.02 two leaves visible stage
Plant structure DEvelopment stage (PDE)	4 leaf senescence stage	0	0.3895	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	E expanded cotyledon stage	0	0.2861	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	F mature embryo stage	0	0.3205	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	C globular stage	0	0.3087	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	D bilateral stage	0	0.301	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.12 twelve leaves visible stage	0	0.479	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.08 eight leaves visible stage	0	0.4752	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.02 two leaves visible stage	0	0.4603	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.10 ten leaves visible stage	0	0.4234	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.04 four leaves visible stage	0	0.3479	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.06 six leaves visible stage	0	0.4268	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	seed development stage	0.00001768	1.304	Informative	DIRECT

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